CN1561744A - Loaded nano magnesium oxide as bactericidal material - Google Patents

Loaded nano magnesium oxide as bactericidal material Download PDF

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Publication number
CN1561744A
CN1561744A CN 200410029592 CN200410029592A CN1561744A CN 1561744 A CN1561744 A CN 1561744A CN 200410029592 CN200410029592 CN 200410029592 CN 200410029592 A CN200410029592 A CN 200410029592A CN 1561744 A CN1561744 A CN 1561744A
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China
Prior art keywords
mgo
loaded nano
load capacity
killing rate
magnesium oxide
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CN 200410029592
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Chinese (zh)
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CN1293810C (en
Inventor
段雪
李殿卿
黄蕾
林彦军
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Beijing University of Chemical Technology
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Beijing University of Chemical Technology
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Priority to CNB2004100295926A priority Critical patent/CN1293810C/en
Priority to PCT/CN2004/001114 priority patent/WO2005092106A1/en
Publication of CN1561744A publication Critical patent/CN1561744A/en
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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y30/00—Nanotechnology for materials or surface science, e.g. nanocomposites
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N59/00—Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds
    • A01N59/06—Aluminium; Calcium; Magnesium; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/16—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using chemical substances
    • A61L2/23—Solid substances, e.g. granules, powders, blocks, tablets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/16—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using chemical substances
    • A61L2/23—Solid substances, e.g. granules, powders, blocks, tablets
    • A61L2/232—Solid substances, e.g. granules, powders, blocks, tablets layered or coated
    • C—CHEMISTRY; METALLURGY
    • C01—INORGANIC CHEMISTRY
    • C01F—COMPOUNDS OF THE METALS BERYLLIUM, MAGNESIUM, ALUMINIUM, CALCIUM, STRONTIUM, BARIUM, RADIUM, THORIUM, OR OF THE RARE-EARTH METALS
    • C01F5/00—Compounds of magnesium
    • C01F5/02—Magnesia
    • C—CHEMISTRY; METALLURGY
    • C01—INORGANIC CHEMISTRY
    • C01P—INDEXING SCHEME RELATING TO STRUCTURAL AND PHYSICAL ASPECTS OF SOLID INORGANIC COMPOUNDS
    • C01P2004/00—Particle morphology
    • C01P2004/60—Particles characterised by their size
    • C01P2004/64—Nanometer sized, i.e. from 1-100 nanometer

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nanotechnology (AREA)
  • Inorganic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Environmental Sciences (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • Plant Pathology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Composite Materials (AREA)
  • Agronomy & Crop Science (AREA)
  • General Physics & Mathematics (AREA)
  • Materials Engineering (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Dentistry (AREA)
  • Geology (AREA)
  • Pest Control & Pesticides (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

A carried nano-magnesium oxide used as bactericide for the black variety of Bacillus subtitis anjd staphylococcus aureus is prepared from MgO nano-particles as active component and Al2O3 as carrier.

Description

Loaded nano magnesia is as sterilization material
Technical field:
The present invention relates to the magnesian purposes of loaded nano, promptly as sterilization material.
Background technology:
The nano magnesia particulate has special matrix type structure, because of it has very little particle diameter, so very big specific surface area is arranged, has certain sterilizing ability.But particle diameter hour, the also corresponding increase of the reunion of nano magnesia.
Document [1] Peter K.Stoimnov, Rosalyn L.Klinger, George L.Marchin, andKenneth J.Klabunde, Langmuir, 2002, point out among the 18:6679-6686 that particle diameter is about 4nm, specific surface reaches 1000m 2The AP-MgO absorption halogen of/g is adsorbed on bacterium and spore surface with electrostatic force, makes cell wall be destroyed, and cell interior liquid flows out, thereby reaches bactericidal effect.Pure AP-MgO then is the form with desiccant, plays bactericidal action.
Document [2] Lee B.I., Rives J.P., Colloids and Surface, 1991, point out among the 56:25 that ultrafine particle has great specific surface area and higher specific surface energy, particle coalescence, reunion very easily take place in preparation and last handling process, form offspring, particle diameter is increased, when final the use, lose the function that ultra-fine grain possesses.In view of above reason, should alleviate the reunion situation of nano magnesia as far as possible, and investigate its sterilizing ability.
Summary of the invention:
The present invention is carried on Al with MgO 2O 3The surface makes it at Al 2O 3Apparent height disperses, to such an extent as to the MgO particle diameter is nanometer scale (4-11nm), this support type MgO has bactericidal action, can be used as sterilization material.
The used loaded nano magnesia sterilization material of the present invention should satisfy following condition, and the carrier of load MgO is the 40-100 order, and specific surface area is 200-300m 2γ-Al of/g 2O 3Particle; The load capacity of MgO (being the mass percent of MgO after the load) is 18%-25%, and the particle diameter of MgO is 4-11nm after the load.
Loaded nano magnesia prepares with following method:
Get 40-100 purpose γ-Al 2O 3Powder is 2%-28% at 500-600 ℃ of following roasting 3-6h by the MgO load capacity, takes by weighing the Mg (NO of respective amount 3) 26H 2O is dissolved in and is made into dipping solution in the deionized water.With γ-Al 2O 3Carrier adds in the maceration extract, stirs down and is evaporated to the existence of intergranular exclusion in boiling temperature.Through 70-120 ℃ be dried to constant weight after, obtain the MgO/ γ-Al of different loads amount in 500 ℃ of roasting 4-12h 2O 3Sample.Show that through sem test the MgO particle diameter is at 4-11nm.
Respectively to the experiment of sterilizing of withered grass bar black mutation gemma and staphylococcus aureus, experimental procedure is as follows with the loaded nano magnesia with different loads amount that obtains:
Accurately take by weighing 0.50g loaded nano magnesia sample, under 120-180 ℃, carried out sterilization treatment 10-60 minute.With the support type MgO/ γ-Al after the sterilization treatment 2O 3Sample, (bacteria containing amount is 10 to place withered grass bar black mutation gemma and staphylococcus aureus respectively 6The cfu/ sheet) in the nutrient solution, behind 37 ℃ of abundant down effect 4h and 24h, takes out supernatant liquor and cultivate, carry out count plate behind the 48h, carry out the calculating of killing rate.The result lists in table 1 and the table 2 respectively.
Table 1 different loads amount MgO/ γ-Al 2O 3Bactericide and withered grass bar black mutation gemma exercising result
The load capacity of MgO Killing rate/% behind the effect 4h Killing rate/% behind the effect 24h
????2％ ????14.32 ????40.00
????5％ ????42.99 ????60.42
????10％ ????71.21 ????80.98
????18％ ????97.98 ????99.91
????20％ ????98.99 ????99.99
????25％ ????98.93 ????99.93
????28％ ????78.93 ????87.93
Table 2 different loads amount MgO/ γ-Al 2O 3Bactericide staphylococcus aureus exercising result
The load capacity of MgO Killing rate/% behind the effect 4h Killing rate/% behind the effect 24h
????2％ ????71.79 ????89.99
????5％ ????86.93 ????92.89
????10％ ????90.36 ????97.99
????18％ ????98.93 ????99.94
????20％ ????99.91 ????99.99
????25％ ????98.98 ????99.98
????28％ ????88.89 ????91.93
By table 1, table 2 as can be seen, when the load capacity of MgO during at 18%-25%, it all greater than 99.9%, has reached the requirement as sterilization material to withered grass bar black mutation gemma and 24 hours killing rate of staphylococcus aureus effect.
Because MgO is at γ-Al 2O 3The threshold value that last individual layer disperses is about 15%, when the load capacity of MgO less than 15% the time, MgO/ γ-Al 2O 3Killing rate to bacterium is lower; After the load capacity of MgO was greater than 15%, MgO began at γ-Al 2O 3The surface forms crystal, along with the increase of load capacity, and the also corresponding increase of the content of the active ingredient MgO crystal of sterilization.When the load capacity of MgO was in the 18%-25% scope, it had good killing effect to withered grass bar black mutation gemma and staphylococcus aureus.The load capacity of MgO was greater than 25% o'clock, and increase of MgO particle diameter and reunion situation are serious, and it drops to about 90% bacterial inactivation rate.When therefore the load capacity of MgO is in the 18-25% scope, bacterium is had very high killing rate, can be used as bactericide and use.
Loaded nano magnesia has been alleviated magnesian reunion effect significantly, when the load capacity of MgO scope, has good bactericidal effect at 18%-25%, compare colourless, nontoxic, characteristics such as sterilization conditions is simple, germicidal efficiency height that loaded nano magnesia sterilization material also has with other bactericide.The preparation method of this loaded nano magnesia sterilization material is easy, is fit to suitability for industrialized production.
Embodiment:
Embodiment 1
Steps A: accurately take by weighing 0.50g and be carried on 40-60 order γ-Al 2O 3On load capacity be MgO/ γ-Al of 18% 2O 3Two parts in sample records and carried out sterilization treatment 60 minutes under 120 ℃.
Step B: with the support type MgO/ γ-Al after the sterilization treatment 2O 3Sample, (bacteria containing amount is 10 to place withered grass bar black mutation gemma and staphylococcus aureus respectively 6The cfu/ sheet) in the nutrient solution.
Step C: sample and bacterium are behind 37 ℃ of abundant down effect 4h and 24h, taking out supernatant liquor cultivates, carry out count plate behind the 48h, carry out the calculating of killing rate, its killing rate to withered grass bar black mutation gemma is respectively 97.98% and 99.91% at 4h and 24h; Killing rate to staphylococcus aureus is respectively 98.93% and 99.94% at 4h and 24h.
Embodiment 2
Steps A: accurately take by weighing 0.50g and be carried on 60-80 order γ-Al 2O 3Upward, load capacity is MgO/ γ-Al of 20% 2O 3Two parts in sample carried out sterilization treatment 30 minutes under 150 ℃.
Step B: with embodiment 1 step B.
Step C: with embodiment 1 step C, load capacity is MgO/ γ-Al of 20% 2O 3Killing rate to withered grass bar black mutation gemma is respectively 98.99% and 99.99% at 4h and 24h; Killing rate to staphylococcus aureus is respectively 99.91% and 99.99% at 4h and 24h.
Embodiment 3
Steps A: accurately take by weighing 0.50g and be carried on 80-100 order γ-Al 2O 3Upward, load capacity is MgO/ γ-Al of 25% 2O 3Two parts in sample carried out sterilization treatment 20 minutes under 180 ℃.
Step B: with embodiment 1 step B.
Step C: with embodiment 1 step C, load capacity is MgO/ γ-Al of 25% 2O 3Killing rate to withered grass bar black mutation gemma is respectively 98.93% and 99.93% at 4h and 24h; Killing rate to staphylococcus aureus is respectively 99.98% and 99.98% at 4h and 24h.

Claims (2)

1. magnesian purposes of loaded nano, it is the 40-100 order that MgO is loaded on particle diameter, specific surface area is 200-300m 2γ-Al of/g 2O 3On the particle, the particle diameter that obtains MgO is the loaded nano magnesia of 4-11nm, it is characterized in that this loaded nano magnesia has bactericidal action.
2. the magnesian purposes of loaded nano as claimed in claim 1, it is characterized in that when the load capacity of MgO is 18%-25%, it all greater than 99.9%, can be used as sterilization material to 24 hours killing rate of withered grass bar black mutation gemma and staphylococcus aureus effect.
CNB2004100295926A 2004-03-26 2004-03-26 Loaded nano magnesium oxide as bactericidal material Expired - Fee Related CN1293810C (en)

Priority Applications (2)

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CNB2004100295926A CN1293810C (en) 2004-03-26 2004-03-26 Loaded nano magnesium oxide as bactericidal material
PCT/CN2004/001114 WO2005092106A1 (en) 2004-03-26 2004-09-28 Use of supported nanoscale mgo as disinfecting material

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Application Number Priority Date Filing Date Title
CNB2004100295926A CN1293810C (en) 2004-03-26 2004-03-26 Loaded nano magnesium oxide as bactericidal material

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CN1293810C CN1293810C (en) 2007-01-10

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Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102428961A (en) * 2011-11-15 2012-05-02 农业部环境保护科研监测所 Method for preparing nano MgO sustained-release sterilizing granules
CN102885087A (en) * 2012-10-16 2013-01-23 中国科学院过程工程研究所 Nanometer magnesium oxide inorganic antibacterial agent, preparation method and applications of nanometer magnesium oxide inorganic antibacterial agent
CN105498679A (en) * 2015-11-24 2016-04-20 常熟理工学院 A preparing method of an immobilized nanometer MgO adsorption material and applications of the material
CN109111598A (en) * 2018-07-18 2019-01-01 安徽江淮汽车集团股份有限公司 A kind of preparation method of antibacterial agent
CN109181239A (en) * 2018-07-18 2019-01-11 安徽江淮汽车集团股份有限公司 A kind of antibacterial antistatic PBT composite and preparation method thereof

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS58193737A (en) * 1982-05-04 1983-11-11 Mitsubishi Heavy Ind Ltd Catalyst for production of gas enriched with hydrogen
JPH03215266A (en) * 1990-01-19 1991-09-20 Nobuhide Maeda Composite ceramics having deodorizing and antibacterial properties and its preparation
JPH075354B2 (en) * 1990-04-10 1995-01-25 信秀 前田 Deodorizing and antibacterial composite ceramics and method for producing the same
JPH07173022A (en) * 1993-12-17 1995-07-11 Asahi Chem Ind Co Ltd Antimicrobial agent
JP3215266B2 (en) * 1994-07-12 2001-10-02 新日本製鐵株式会社 Method for producing austenitic stainless steel sheet with excellent image clarity
JP2920123B2 (en) * 1997-05-26 1999-07-19 信秀 前田 A method for producing a paint having far-infrared radiation properties, antibacterial properties, deodorizing properties, fungicidal properties and insect repellency, and having an antistatic effect
JPH1129354A (en) * 1997-07-11 1999-02-02 Nippon Mizushiyori Giken:Kk Production of electromagnetic wave emitting ceramic powder material
US6417423B1 (en) * 1998-09-15 2002-07-09 Nanoscale Materials, Inc. Reactive nanoparticles as destructive adsorbents for biological and chemical contamination
US6653519B2 (en) * 1998-09-15 2003-11-25 Nanoscale Materials, Inc. Reactive nanoparticles as destructive adsorbents for biological and chemical contamination
CN1115381C (en) * 1999-03-30 2003-07-23 中国石油化工集团公司 Method (B) for oxidation of thioalcohole in petroleum fraction

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102428961A (en) * 2011-11-15 2012-05-02 农业部环境保护科研监测所 Method for preparing nano MgO sustained-release sterilizing granules
CN102428961B (en) * 2011-11-15 2013-07-17 农业部环境保护科研监测所 Method for preparing nano MgO sustained-release sterilizing granules
CN102885087A (en) * 2012-10-16 2013-01-23 中国科学院过程工程研究所 Nanometer magnesium oxide inorganic antibacterial agent, preparation method and applications of nanometer magnesium oxide inorganic antibacterial agent
CN102885087B (en) * 2012-10-16 2014-09-24 中国科学院过程工程研究所 Nanometer magnesium oxide inorganic antibacterial agent, preparation method and applications of nanometer magnesium oxide inorganic antibacterial agent
CN105498679A (en) * 2015-11-24 2016-04-20 常熟理工学院 A preparing method of an immobilized nanometer MgO adsorption material and applications of the material
CN105498679B (en) * 2015-11-24 2018-11-16 常熟理工学院 A kind of preparation method and application of immobilized nano-MgO adsorbent material
CN109111598A (en) * 2018-07-18 2019-01-01 安徽江淮汽车集团股份有限公司 A kind of preparation method of antibacterial agent
CN109181239A (en) * 2018-07-18 2019-01-11 安徽江淮汽车集团股份有限公司 A kind of antibacterial antistatic PBT composite and preparation method thereof

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CN1293810C (en) 2007-01-10

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