CN1557469A - Natural calcium replenishing nutrient - Google Patents
Natural calcium replenishing nutrient Download PDFInfo
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- CN1557469A CN1557469A CNA2004100161033A CN200410016103A CN1557469A CN 1557469 A CN1557469 A CN 1557469A CN A2004100161033 A CNA2004100161033 A CN A2004100161033A CN 200410016103 A CN200410016103 A CN 200410016103A CN 1557469 A CN1557469 A CN 1557469A
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Abstract
The present invention relates to natural calcium replenishing nutriment easily absorbed by human body, and is especially macro molecular saccharide-casein calcium and casein polypeptide calcium phosphate as natural calcium replenishing preparation prepared from casein and its preparation process and application. The present invention features that casein and relevant material is hydrolyzed with trypsase and/or chymotrypsin and through further separation in superfiltering apparatus and concentration, natural calcium replenishing nutriment with macro molecular saccharide-casein calcium and/or casein polypeptide calcium phosphate as main components is prepared. The natural calcium replenishing nutriment is prepared into additive or medicine for human body to replenish calcium.
Description
Affiliated technical field
The present invention relates to the natural calcium-supplementing nutritive agent that a kind of human body absorbs easily, relate in particular to a kind of method and application that from the cheese dawn is white, prepares natural one cheese dawn of calcium-supplementing preparation white sugar macromole calcium and cheese dawn white phosphorus acid polypeptide calcium.
The invention technical field
Calcium is human body requirements amount maximum, essential constant mineral element.Calcic is about 1.2～1.3 kilograms in the normal adult body, calcium is the main component part of skeleton, calcium deficiency often causes various diseases, as rickets, osteoporosis etc., scientific research shows that organism generally lacks calcium constituent, and is not easy to supply, the diet structure that Chinese form has for a long time caused the intake of calcium on the low side, and Chinese also are not so good as other nationalitys to the absorbability of metallic element.
A large amount of epidemiologic datas confirms that Chinese ubiquity the calcium deficiency problem, and is particularly outstanding and serious in child and mid-aged population, and the deficiency that only relies on diet to satisfy calcium intake is very difficult.
Solving the calcium deficiency problem, must set about from two aspects simultaneously, is the intake that increases calcium on the one hand, be the bio-absorbable utilization rate that increases calcium on the other hand, at present, the intake problem that increases calcium has been subjected to common concern, and the problem of calcium absorption utilization rate also is not resolved.
The main method that promotes calcium absorption is the absorption that promotes calcium by the consumption that increases vitamin D, but vitamin D only can promote duodenum and upper part of small intestine calcium ion to absorb, and the effect of vitamin D and age and calcium intake relation are bigger, and the vitamin D excess intake can cause certain harm to kidney and sclerotin.
In the intestinal of human small intestine bottom than length is the main place of calcium absorption, account for calcium absorption threshold values 70～80% in the body, calcium absorption mechanism is that the Concentraton gradient difference that relies on calcium ion in the intestinal is finished, in the small intestinal lower area, PH is 7～8, be alkalescence, be easy to form insoluble calcium phosphate, thereby the absorption of restriction calcium, research data proves, the calcium that human body absorbs from diet, and its absorbance is only 21～26%, improve the absorption rate of human body, must block the interior calcium of intestinal and combine the insoluble calcium phosphate that forms with phosphoric acid calcium.
Zoopery and clinical trial confirm, cheese dawn white phosphorus acid polypeptide (CPP) can combine with calcium in small intestinal and form soluble calcium salt, under physiology PH, has extraordinary dissolubility, very easily be absorbed by the body, and cheese dawn white phosphorus acid polypeptide to derive from the crude milk dawn white, take nontoxic pair of effect for a long time, external zoopery confirmed to add cheese dawn white phosphorus acid polypeptide calcium after four months in the beverage of nutrition purposes, especially for feeding animals, and its relative bone density obviously improves.Cheese dawn white phosphorus acid polypeptide can produce in vain by the hydrolysis cheese dawn.
The cheese dawn is white-and sugared macromole peptide is a K-cheese dawn white sugar peptide, it is a kind of cheese dawn plain boiled water hydrolysis products, it is sialylated macromole peptide, account for the K-cheese dawn white 40%, external scientist finds, contain the cheese dawn white-compositions of sugared macromole peptide perhaps is used for the treatment of osteopathia and odontopathy and has significant positive role keeping the health of bone or tooth.In vitro tests shows, the cheese dawn is white-and sugared macromole peptide can reduce the activity of osteoclast, increase the osteoblast activity, reducing the sclerotin composition loses, reduce separating out of calcium, have with cheese dawn white phosphorus acid polypeptide and similarly act on, be combined into the solubility calcium salt form with calcium, promote human calcium's Absorption in small intestinal bottom alkalescence zone.
In the technology that United States Patent (USP) (5290685) is announced, announced the method that from the cheese dawn is white, prepares polypeptide phosphate, by the method purification polypeptide phosphate with dehydrated alcohol, this method cost height, process complexity.
The technology that Chinese invention patent (98114267.2) is announced is to adopt lactobacillus to decompose breast white polypeptide of dawn, the process complexity, and form the big or small wayward of polypeptide.
Technical problem to be solved by this invention is, white or its Related product is a raw material with the cheese dawn, adopt the mode of white catabolic enzyme hydrolysis of dawn to prepare polypeptide phosphate calcium and/or the cheese dawn white-sugared macromole peptide calcium, the natural calcium-supplementing nutritive agent that absorbs easily as human body.
Summary of the invention
The present invention solves the problems of the technologies described above the technical scheme that is adopted, it is characterized in that, with cheese dawn its Related product of Pseudobulbus Bletillae (Rhizoma Bletillae) is raw material, carrying out dawn plain boiled water by dan white pancreatic enzyme and/or white enzyme of pancreas curdled milk dawn separates, separate, concentrate with ultrafiltration apparatus, preparation with cheese dawn white phosphorus acid polypeptide calcium and/or cheese dawn white-sugared macromole peptide calcium is the natural calcium-supplementing nutritive agent of Main Ingredients and Appearance, and helps calcium replenishing by being prepared into food additive or pharmaceutical dosage forms.
Technical characterictic of the present invention is, the raw material for preparing natural calcium-supplementing nutritive agent as the present invention can be cheese dawn its Related product of Pseudobulbus Bletillae (Rhizoma Bletillae), comprise powdered raw materials such as cheese dawn white lead, industrial casein, cheese acid sodium, dried potassium caseinate, cheese ammonium phosphate, milk powder, also can adopt liquid charging stocks such as fresh milk or freezing milk.
Technical characterictic of the present invention is, if adopt liquid milk as raw material, must use the centrifugation defat, the sour agent of skim milk, preferably hydrochloric acid is transferred PH to 4.6～4.8, and be heated to 30 ℃～50 ℃ and keep that to solidify the cheese dawn in 20～50 minutes white, with centrifugation or to collect the cheese dawn with the filtering mode of nylon filter cloth white, be used for further dawn plain boiled water and separate program.
Technical characterictic of the present invention is, if with the cheese hydrochlorate, for example cheese acid sodium, dried potassium caseinate are raw material, should adding distil water be deployed into 3% cheese acid salt solution, add 20ml Chymosin (rennet) in per 100 liters of cheese acid salt solutions, under 30 ℃～45 ℃ temperature, kept 40～60 minutes, and added sour agent and transfer PH to 4.6～4.8, be heated to 30 ℃～50 ℃ and kept 20～40 minutes, it is white that centrifugation or filter type are collected the cheese dawn of solidifying, and prepares further to carry out dawn plain boiled water and separate program.
Technical characterictic of the present invention is, collecting the cheese acid salt solution solidifies and separates out the supernatant of cheese dawn after white, wherein contain the abundant cheese dawn white-sugared macromole peptide, in supernatant, add alkaline agent and transfer PH to 6.5～6.7, centrifugal back with centrifuge with the remaining dawn white matter of solidifying of metal screen filtering with the speed of 1000～2000 rev/mins of per minutes, in supernatant, slowly add calcium chloride, whenever go up and add 0.3～0.9 gram calcium chloride in the clear liquid, fully stir, holding temperature continues 2～3 hours at 30 ℃～40 ℃, with molecular weight is 2,000～4, the ultrafilter membrane of 000D separates the cheese dawn white-sugared macromole peptide calcium, concentrated solution is dried to powder, include the abundant cheese dawn white-sugared macromole peptide calcium.
Technical characterictic of the present invention is, the cheese dawn of collecting coagulation sedimentation is white, the cheese dawn is dissolved in 50 ℃～85 ℃ the distilled water by 5～30% inventorys in vain, adds alkali liquor and transfer PH to 7～9, homogenizing operating pressure 8～15Mpa high pressure homogenize becomes the pasty state base material, press enzyme concentration 0.08%～1.5%, preferably 0.4%～0.6% drop into dan white pancreatic enzyme, transfer pH value to 3～6, under 37 ℃～54 ℃ temperature are bathed, kept 2～8 hours, the hydrolysis cheese dawn is white, after enzymolysis process is finished, heat rapidly to 10 minutes deactivation dan white pancreatic enzymes of 85 ℃ of insulations, white hydrolyzed solution of dawn is 5 by molecular weight, 000～15, the ultrafilter membrane of 000D, the macromole dawn of separating not abundant hydrolysis is white, collects ultrafiltration supernatant liquid, press 20～40% of supernatant capacity and drop into calcium chloride (weight/volume percentage ratio), fully stirring 2～5 hours under 30 ℃～40 ℃ temperature, is 1,000～5 with molecular weight, 000D, preferably 2,000～3, after the ultrafilter membrane of 000D concentrates, spray drying or vacuum drying become powder, include the abundant cheese dawn white-polypeptide phosphate calcium.
Technical characterictic of the present invention is, abundant in order to allow dawn plain boiled water separate process, and guarantee the white chain interruption of most of dawn, a kind of mode of improvement can be, dawn plain boiled water separate carry out one hour after, continue with staggered tangent plane fluid ultrafiltration apparatus, adopting molecular weight is 8,000～12, the ultrafilter membrane of 000D continues isolated by filtration, molecular weight continues to be collected less than the micromolecule polypeptide in ultrafilter membrane aperture, and molecular weight greater than the ultrafilter membrane aperture not fully the dawn white matter molecule of hydrolysis sent back to dawn plain boiled water again and separate and continue hydrolysis in the reaction pot, this method not only makes the micromolecule polypeptide that has been hydrolyzed continue to be collected, and can also promote the cross reaction contact between the white and enzyme of dawn, and it is more thorough that dawn plain boiled water is separated.
Technical characterictic of the present invention is, cheese dawn white phosphorus acid polypeptide is except forming polypeptide phosphate calcium with calcium, can also and magnesium, zinc, ferrum, phosphorus, trace element such as copper are combined into metallo-chelate, and promote these trace elements absorbed, another modification method of the present invention also can be in white hydrolyzed solution of the dawn of being rich in polypeptide phosphate except that adding calcium chloride, add magnesium sulfate in proportion, ferrous sulfate, zinc chloride, trace element such as copper chloride, to help human body to replenish the metallo-chelate of multiple easy absorption simultaneously, especially add magnesium metal, can also promote calcium in absorption by human body, increase the bioavailability of calcium.
Technical characterictic of the present invention is, the cheese dawn white phosphorus acid polypeptide calcium and/or the cheese dawn of the inventive method preparation is white-and sugared macromole peptide calcium can use separately, and use in conjunction can obtain better effect, the natural calcium-supplementing nutritive agent of the inventive method preparation is applicable to prevention and treats osteoporosis, rickets, promote union of fracture after can be used for fracturing, also can be used as child, middle-aged and elderly people, anemia of pregnant woman's daily calcium-supplementing nutritive agent.
Technical characterictic of the present invention is, the natural calcium-supplementing nutritive agent of the inventive method preparation can be used as food additive and adds in the varieties of food items, become the condensed food of replenishing the calcium, include but not limited to, numerous food forms such as milk powder, milk extract, condensed milk, cookies, cake, confection, the pouring of ice fine jade, pudding, fruit jelly, electuary, fruit juice, coffee, teabag also can be mixed with into various ways such as tablet, chewable tablet, buccal tablet, effervescent tablet, soft capsule, hard capsule, Emulsion, granule, pill, membrane for taking with the adjuvant of medical-grade.
The invention has the beneficial effects as follows, the polypeptide phosphate calcium and the cheese dawn of the inventive method preparation is white-and sugared macromole peptide calcium can be at human small intestine's hypomere alkalescence zone formation soluble calcium salt, promote absorption of human body to utilize calcium ion, be best suited for the calcium-supplementing preparation of absorption of human body form, and belong to the natural nutrition agent, take safe and reliablely for a long time, do not have any poison and pay effect.
The specific embodiment
The invention will be further described below in conjunction with embodiment:
Embodiment
Preparation cheese dawn white phosphorus acid polypeptide calcium and cheese dawn are white-sugared macromole peptide calcium
With 100 kilograms of cheese acid sodium is raw material, cheese acid sodium solution with dissolved in distilled water allotment 3%, add Chymosin 20ml/100 and rise solution, transfer PH to 6.8, be warming up to 37 ℃ and kept 50 minutes, add 4N HCL and transfer PH to 4.6, be heated to 40 ℃ and kept 20 minutes, with the speed of 5000 rev/mins in centrifuge centrifugal 15 minutes, it was white to precipitate the agglutinative cheese dawn.
Collect supernatant, potassium hydroxide with 2N is transferred PH to 6.6, filter with 200 order metal screens with 1000 rev/mins of centrifugal backs of speed, the calcium chloride that adds 0.5 grams per liter in the supernatant, with molecular weight is 3, and the ultrafilter membrane of 000D is separating and filtering on staggered tangent plane fluid ultrafiltration apparatus, and is concentrated into start volume 20%, spraying drying powder-forming, obtain be rich in the cheese dawn white-dry powder of sugared macromole peptide calcium.
In being 6.2% white solution of cheese dawn, concentration drops into 50 ℃ distilled water, add the 2N potassium hydroxide and transfer PH to 8, the homogenizing operating pressure is 12Mpa, enzyme concentration is 4 gram/L (weight/volume percentage ratios), add dan white pancreatic enzyme (Sigma Pancretin ofbovin origin having an activity 4 NF), PH maintains about PH8 with the potassium hydroxide of 2N in the reaction pot, temperature maintenance is at 37 ℃～40 ℃, continue 6 hours, began back one hour at enzymolysis, white hydrolyzed solution of dawn begins that (the ultrafilter membrane molecular weight is 10 at staggered tangent plane fluid ultrafiltration apparatus, 000D) and between the enzyme digestion reaction pot circulate repeatedly, collect the micromolecule polypeptide of osmotic ultrafiltration film, the not hydrolysis dawn of macromolecule is sent into enzymolysis in the reaction pot in vain again, enzymolysis process finishes, heat to 90 ℃ and kept 10 minutes, the deactivation dan white pancreatic enzyme, (the ultrafilter membrane molecular weight is 10 to white hydrolyzed solution of dawn, and 000D) separating and filtering merges ultrafiltration supernatant liquid through ultrafiltration apparatus in the reaction pot, add calcium chloride 20% (weight/volume percentage ratio), fully stirring reaction is 2 hours, is 2 with molecular weight, and the ultrafilter membrane of 000D is concentrated into 20% of initial capacity, be spray dried to dry powder, obtain be rich in the cheese dawn white-dry powder of polypeptide phosphate calcium.
Claims (10)
1. the present invention relates to the natural calcium-supplementing nutritive agent that a kind of human body absorbs easily, relate in particular to a kind of method and application that from the cheese dawn is white, prepares natural one cheese dawn of calcium-supplementing preparation white sugar macromole calcium and cheese dawn white phosphorus acid polypeptide calcium, it is characterized in that, with cheese dawn its Related product of Pseudobulbus Bletillae (Rhizoma Bletillae) is raw material, carrying out dawn plain boiled water by dan white pancreatic enzyme and/or white enzyme of pancreas curdled milk dawn separates, separate with ultrafiltration apparatus, concentrate, preparation with cheese dawn white phosphorus acid polypeptide calcium and/or cheese dawn white-sugared macromole peptide calcium is the natural calcium-supplementing nutritive agent of Main Ingredients and Appearance, and helps calcium replenishing by being prepared into food additive or pharmaceutical dosage forms.
2. in accordance with the method for claim 1, technical characterictic of the present invention is, the raw material for preparing natural calcium-supplementing nutritive agent as the present invention can be cheese dawn its Related product of Pseudobulbus Bletillae (Rhizoma Bletillae), comprise powdered raw materials such as cheese dawn white lead, industrial casein, cheese acid sodium, dried potassium caseinate, cheese ammonium phosphate, milk powder, also can adopt liquid charging stocks such as fresh milk or freezing milk.
3. in accordance with the method for claim 1, technical characterictic of the present invention is, if adopt liquid milk as raw material, must use the centrifugation defat, the sour agent of skim milk, preferably hydrochloric acid is transferred PH to 4.6～4.8, and is heated to 30 ℃～50 ℃ and keeps that to solidify the cheese dawn in 20～50 minutes white, with centrifugation or to collect the cheese dawn with the filtering mode of nylon filter cloth white, be used for further dawn plain boiled water and separate program.
4. in accordance with the method for claim 1, technical characterictic of the present invention is, if with the cheese hydrochlorate, for example cheese acid sodium, dried potassium caseinate are raw material, should adding distil water be deployed into 3% cheese acid salt solution, add 20ml Chymosin (rennet) in per 100 liters of cheese acid salt solutions, under 30 ℃～45 ℃ temperature, kept 40～60 minutes, add sour agent and transfer PH to 4.6～4.8, be heated to 30 ℃～50 ℃ and kept 20～40 minutes, it is white that centrifugation or filter type are collected the cheese dawn of solidifying, and prepares further to carry out dawn plain boiled water and separate program.
5. in accordance with the method for claim 1, technical characterictic of the present invention is, collecting the cheese acid salt solution solidifies and separates out the supernatant of cheese dawn after white, wherein contain the abundant cheese dawn white-sugared macromole peptide, in supernatant, add alkaline agent and transfer PH to 6.5～6.7, centrifugal back with centrifuge with the remaining dawn white matter of solidifying of metal screen filtering with the speed of 1000～2000 rev/mins of per minutes, in supernatant, slowly add calcium chloride, whenever go up and add 0.3～0.9 gram calcium chloride in the clear liquid, fully stir, holding temperature continues 2～3 hours at 30 ℃～40 ℃, with molecular weight is 2,000～4, the ultrafilter membrane of 000D separates the cheese dawn white-sugared macromole peptide calcium, concentrated solution is dried to powder, include the abundant cheese dawn white-sugared macromole peptide calcium.
6. in accordance with the method for claim 1, technical characterictic of the present invention is, the cheese dawn of collecting coagulation sedimentation is white, the cheese dawn is dissolved in 50 ℃～85 ℃ the distilled water by 5～30% inventorys in vain, add alkali liquor and transfer PH to 7～9, homogenizing operating pressure 8～15Mpa high pressure homogenize becomes the pasty state base material, press enzyme concentration 0.08%～1.5%, preferably 0.4%～0.6% drop into dan white pancreatic enzyme, transfer pH value to 3～6, under bathing, 37 ℃～54 ℃ temperature kept 2～8 hours, the hydrolysis cheese dawn is white, after enzymolysis process is finished, heat rapidly to 10 minutes deactivation dan white pancreatic enzymes of 85 ℃ of insulations, white hydrolyzed solution of dawn is 5,000～15 by molecular weight, the ultrafilter membrane of 000D, the macromole dawn of separating not abundant hydrolysis is white, collect ultrafiltration supernatant liquid, press 20～40% of supernatant capacity and drop into calcium chloride (weight/volume percentage ratio), under 30 ℃～40 ℃ temperature, fully stirred 2～5 hours, with molecular weight is 1,000～5,000D, preferably 2,000～3, after the ultrafilter membrane of 000D concentrated, spray drying or vacuum drying became powder, include the abundant cheese dawn white-polypeptide phosphate calcium.
7. in accordance with the method for claim 1, technical characterictic of the present invention is, abundant in order to allow dawn plain boiled water separate process, and guarantee the white chain interruption of most of dawn, a kind of mode of improvement can be, dawn plain boiled water separate carry out one hour after, continue with staggered tangent plane fluid ultrafiltration apparatus, adopting molecular weight is 8,000～12, the ultrafilter membrane of 000D continues isolated by filtration, molecular weight continues to be collected less than the micromolecule polypeptide in ultrafilter membrane aperture, and molecular weight greater than the ultrafilter membrane aperture not fully the dawn white matter molecule of hydrolysis sent back to dawn plain boiled water again and separate and continue hydrolysis in the reaction pot, this method not only makes the micromolecule polypeptide that has been hydrolyzed continue to be collected, can also promote the cross reaction contact between the white and enzyme of dawn, it is more thorough that dawn plain boiled water is separated.
8. in accordance with the method for claim 1, technical characterictic of the present invention is, cheese dawn white phosphorus acid polypeptide is except forming polypeptide phosphate calcium with calcium, can also and magnesium, zinc, ferrum, phosphorus, trace element such as copper are combined into metallo-chelate, and promote these trace elements absorbed, another modification method of the present invention also can be in white hydrolyzed solution of the dawn of being rich in polypeptide phosphate except that adding calcium chloride, add magnesium sulfate in proportion, ferrous sulfate, zinc chloride, trace element such as copper chloride, to help human body to replenish the metallo-chelate of multiple easy absorption simultaneously, especially add magnesium metal, can also promote calcium in absorption by human body, increase the bioavailability of calcium.
9. in accordance with the method for claim 1, technical characterictic of the present invention is, the cheese dawn white phosphorus acid polypeptide calcium and/or the cheese dawn of the inventive method preparation is white-and sugared macromole peptide calcium can use separately, and use in conjunction can obtain better effect, the natural calcium-supplementing nutritive agent of the inventive method preparation is applicable to prevention and treats osteoporosis, rickets, promote union of fracture after can be used for fracturing, also can be used as child, middle-aged and elderly people, anemia of pregnant woman's daily calcium-supplementing nutritive agent.
10. in accordance with the method for claim 1, technical characterictic of the present invention is, the natural calcium-supplementing nutritive agent of the inventive method preparation can be used as food additive and adds in the varieties of food items, become the condensed food of replenishing the calcium, include but not limited to, milk powder, milk extract, condensed milk, cookies, cake, confection, the ice fine jade drenches, pudding, fruit jelly, electuary, fruit juice, coffee, numerous food forms such as teabag also can be mixed with into tablet with the adjuvant of medical-grade, chewable tablet, buccal tablet, effervescent tablet, soft capsule, hard capsule, Emulsion, granule, pill, various ways such as membrane are for taking.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2004100161033A CN1557469A (en) | 2004-02-04 | 2004-02-04 | Natural calcium replenishing nutrient |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2004100161033A CN1557469A (en) | 2004-02-04 | 2004-02-04 | Natural calcium replenishing nutrient |
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| CN1557469A true CN1557469A (en) | 2004-12-29 |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102719509A (en) * | 2012-06-14 | 2012-10-10 | 徐佳立 | Casein phosphopeptide and preparation method thereof |
| CN103230020A (en) * | 2013-04-15 | 2013-08-07 | 武汉工业学院 | Preparation method of protein short peptide chelated calcium |
| CN104664375A (en) * | 2015-02-10 | 2015-06-03 | 国家海洋局第三海洋研究所 | Preparation method and application of casein peptide chelate calcium powder |
| CN105085650A (en) * | 2015-08-31 | 2015-11-25 | 苏州普罗达生物科技有限公司 | Small molecular milk casein polypeptide and preparing method |
| CN108531533A (en) * | 2018-04-18 | 2018-09-14 | 阿坝县凯安生物制品有限公司 | A kind of production method with the wet cheese processing casein phosphopeptide of yak |
-
2004
- 2004-02-04 CN CNA2004100161033A patent/CN1557469A/en active Pending
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102719509A (en) * | 2012-06-14 | 2012-10-10 | 徐佳立 | Casein phosphopeptide and preparation method thereof |
| CN102719509B (en) * | 2012-06-14 | 2015-12-16 | 徐佳立 | A kind of casein phosphopeptide and preparation method thereof |
| CN103230020A (en) * | 2013-04-15 | 2013-08-07 | 武汉工业学院 | Preparation method of protein short peptide chelated calcium |
| CN103230020B (en) * | 2013-04-15 | 2014-07-23 | 武汉工业学院 | Preparation method of protein short peptide chelated calcium |
| CN104664375A (en) * | 2015-02-10 | 2015-06-03 | 国家海洋局第三海洋研究所 | Preparation method and application of casein peptide chelate calcium powder |
| CN105085650A (en) * | 2015-08-31 | 2015-11-25 | 苏州普罗达生物科技有限公司 | Small molecular milk casein polypeptide and preparing method |
| CN108531533A (en) * | 2018-04-18 | 2018-09-14 | 阿坝县凯安生物制品有限公司 | A kind of production method with the wet cheese processing casein phosphopeptide of yak |
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