CN1192334A - Method for preparing iron enriched nutrient and products thereof - Google Patents
Method for preparing iron enriched nutrient and products thereof Download PDFInfo
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- CN1192334A CN1192334A CN98100374A CN98100374A CN1192334A CN 1192334 A CN1192334 A CN 1192334A CN 98100374 A CN98100374 A CN 98100374A CN 98100374 A CN98100374 A CN 98100374A CN 1192334 A CN1192334 A CN 1192334A
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- edta
- iron
- iron salt
- salt
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- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
The iron enriching substance is produced by reacting sodium salt of EDTA and iron salt in certain proportion, then regulating pH, concentrating, filtering, recrystallization and drying. The prepn. method is scientific and rational, simple and easy to carry out. The product is good in solubility, stable, no bad smell, no toxic or side-effect and is easy to be absorbed by human body.
Description
The present invention relates to preparation method of health nutrient additive, particularly a kind of iron enriched nutrient and products thereof.
At present, the whole world has 300,000,000 populations to be subjected to the bad puzzlement of iron nutrition condition approximately, and wherein 50% is hypoferric anemia.The average hypoferric anemia incidence of disease of China's age groups is 20%.Benefit chalybeate commonly used at present is divided into two classes, and a class is a heme iron, is mainly derived from animal blood, and its absorptivity in human body is higher, but raw material is few, and the processing cost height is difficult to use on market; Another kind of is nonheme iron, is mainly various molysite, and its absorptivity is lower, and the food carrier sense organ is easily produced harmful effect, and is subjected to the influence of various iron absorption inhibiting factors in the food, and molysite also can cause side effects such as digestive discomfort.
The purpose of this invention is to provide that a kind of can to prepare absorptivity higher, good water solubility, cheap, stability is strong, suits one's taste and waits the preparation method who does not have the iron enriched nutrient that obviously influences.
Another object of the present invention provides a kind of product that utilizes above-mentioned preparation method to make.
Preparation method of the present invention comprises the sodium salt of ethylenediamine tetra-acetic acid (being designated as EDTA) and molysite in water, under 0～60 ℃, regulates PH to 1-7, react 0.1～2 hour, concentrated after after filtration, be recrystallized, be drying to obtain product.
Molysite can be trivalent iron salt or divalent iron salt described in the preparation method of the present invention; Trivalent iron salt is preferably ferric nitrate, ferric trichloride; Divalent iron salt is preferably ferrous sulfate, ferrous lactate.
Regulate the pH value process described in the preparation method of the present invention and can adopt sodium acid carbonate and/or NaOH.
Concentration process described in the preparation method of the present invention can adopt decompression to concentrate or quiescent setting 2-48 hour quiescent time.
Recrystallization process described in the preparation method of the present invention can adopt the 50-100% ethanolic solution to carry out recrystallization 2-5 time.
Dry run is preferably used air dry described in the preparation method of the present invention.
Preparation method of the present invention can also comprise that the NaFe-EDTA crystallization that will make further gets tablet, capsule, oral liquid or other F﹠B with other mixed raw material.
The product that adopts preparation method of the present invention to make is light yellow to brown NaFe-EIDTA crystallization or powder, has well water-soluble.
Preparation method of the present invention is scientific and reasonable, and is simple; Products made thereby good water solubility, stable strong, free from extraneous odour has no side effect, human absorptivity's height, and cost is low, and profitable; Can make nutritional health food and medicine as the iron enriched nutrient of various food with reinforcement iron effect.
Result of study shows that NaFe-EDTA strengthens respectively in sugar, milk, cassava powder, flour and corn flour, and its absorptivity and molysite are close, but the influence of inhibiting factor in the unable to take food thing; In different foods, its absorptivity basically identical; In containing the food that absorbs inhibiting factor more by force, in cereal, the absorptivity of NaFe-EDTA than the high 2-3 of molysite doubly; Research also shows, the absorption of NaFe-EDTA is subjected to iron in the food equally and promotes the effect of the factor such as meat, VC etc. and improve; Particularly the absorptivity of NaFe-EDTA fortified milk and flour reaches 16.8% and 14.6% respectively, compares FeSO
4Absorptivity exceed 8.4% and 6.6% respectively.
The present invention will be further described below in conjunction with embodiment.
Embodiment 1
A kind of method that ferric nitrate, 2Na-EDTA and Vc prepare iron nutritional supplementation tablet and products thereof of utilizing, its process is:
Getting the 25.048g ferric nitrate is dissolved in the 50ml water, getting 23.79g2Na-EDTA is dissolved in the 100ml water, slowly sneak into 2Na-EDTA solution in the iron nitrate solution, regulate pH value to 5 with sodium acid carbonate and NaOH, reacted 1 hour, filter after leaving standstill 3hr, be recrystallized 3 times, can obtain the NaFe-EDTA of 17.5g light brown with 80% ethanolic solution; The NaFe-EDTA of 50mg is mixed with 30mgVc and auxiliary material, can make that mouthfeel is good, the chewable tablets of easy absorption, the heavy 0.5g of sheet can be used for replenishing ferro element, prevents and treats hypoferric anemia.
Embodiment 2
A kind of preparation method of iron supplement capsules.Its process is:
Get FeCL
316.74g be dissolved in the 50ml water, get 2Na-EDTA24g and be dissolved in the 100ml water, after the two mixes, regulate pH value to 5 with sodium acid carbonate and NaOH, reacted 1.5 hours, filter behind the static 4hr, to filter thing and be recrystallized 3 times, can obtain 16.1gNaFe-EDTA after the drying with 90% ethanolic solution; With NaFe-EDTA and Vc, folic acid, V
B12, zinc lactate and the compound capsule of making of pyridoxol, each heavy 0.6g can be used for preventing and treating various Anemias.
Embodiment 3
A kind of preparation method who mends iron oral liquid, its process is:
Get FeSO
410.54g be dissolved in the 30ml water, get 2Na-EDTA24g and be dissolved in the 100ml water, after the two mixes, transfer PH to 5 with NaOH, reacted 2 hours, filter after leaving standstill 4hr, to filter thing and be recrystallized 3 times, can obtain the 15.9gNaFe-EDTA brown crystal after the drying with 70% ethanolic solution;
NaFe-EDTA and Hei Jialun fruit juice, Vc are mixed and made into oral liquid, and unit packaging is 10ml or 5ml, can be used for preventing and treating hypoferric anemia.
Embodiment 4
A kind of preparation method of iron enriched nutrient, process is as follows:
The ferrous 17.8g of extracting lactic acid is dissolved in 50ml water, getting 2Na-EDTA 24g is dissolved in the 100ml water, after the two mixes, regulate pH value to 5 with sodium acid carbonate, reacted 2 hours, leave standstill 5 hours after, be evaporated to 50ml with vavuum pump, filter, the filter thing adopts 80% alcohol crystal 5 times, obtains 15.5gNaFe-EDTA after the air dry.
During use,, add 200mg-440mgNaFe-EDTA in the foods such as per kilogram flour, bean powder, milk powder as the iron enriched nutrient of condensed food; Or really add 50-400mgNaFe-EDTA in milk, sour milk, the lactic acid drink at every liter of all kinds of carbonated drinks, soy sauce, soft drink, pattern.
Described embodiment just further specifies of the present invention, and should not be construed as is limitation of the present invention.
Claims (8)
1, a kind of preparation method of iron enriched nutrient is characterized in that the sodium salt of EDTA and molysite regulating PH to 1-7 in water, under 0～60 ℃, react 0.1～2 hour, concentrated after after filtration, be recrystallized, be drying to obtain product.
2, preparation method as claimed in claim 1 is characterized in that described molysite is trivalent iron salt or divalent iron salt; Trivalent iron salt is preferably ferric nitrate, ferric trichloride; Divalent iron salt is preferably ferrous sulfate, ferrous lactate.
3, preparation method as claimed in claim 1 is characterized in that described adjusting pH value process adopts sodium acid carbonate and/or NaOH.
4, preparation method as claimed in claim 1 is characterized in that described concentration process adopts decompression to concentrate or quiescent setting, and be 2-48 hour quiescent time.
5, preparation method as claimed in claim 1 is characterized in that described recrystallization process adopts the 50-100% ethanolic solution to carry out recrystallization 2-5 time.
6, preparation method as claimed in claim 1 is characterized in that described dry run preferably uses air dry.
7, preparation method as claimed in claim 1 is characterized in that the NaFe-EDTA crystallization that will make further gets tablet, capsule, oral liquid with other mixed raw material.
8, a kind of iron enriched nutrient, the product that it is characterized in that adopting the method as one of claim 1-7 to make.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN98100374A CN1065726C (en) | 1998-01-23 | 1998-01-23 | Method for preparing iron enriched nutrient and products thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN98100374A CN1065726C (en) | 1998-01-23 | 1998-01-23 | Method for preparing iron enriched nutrient and products thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1192334A true CN1192334A (en) | 1998-09-09 |
| CN1065726C CN1065726C (en) | 2001-05-16 |
Family
ID=5215992
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN98100374A Expired - Fee Related CN1065726C (en) | 1998-01-23 | 1998-01-23 | Method for preparing iron enriched nutrient and products thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1065726C (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100346725C (en) * | 2001-08-03 | 2007-11-07 | 卡夫食品集团公司 | Stable and bioavailable iron fortified beverages |
| CN101481319B (en) * | 2009-02-04 | 2011-12-14 | 北京维他科技有限公司 | Method for drying super-fine sodium iron ethylenediaminetetraacetate (NaFeEDTA) product capable of rapidly dissolvable |
| CN105837461A (en) * | 2015-01-17 | 2016-08-10 | 杨俊� | Production technology of high purity iron supplement agent sodium feredetate |
| CN111714470A (en) * | 2020-05-27 | 2020-09-29 | 天津瑞益瑞美生物技术有限公司 | Sustained-release ethylenediamine tetraacetic acid iron sodium premix for animals and preparation method thereof |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5328416B2 (en) * | 1973-03-12 | 1978-08-15 | ||
| US5159094A (en) * | 1991-05-15 | 1992-10-27 | W.R. Grace & Co.-Conn. | Process for the preparation of solid iron (III) complexes |
| CO4410161A1 (en) * | 1994-02-28 | 1997-01-09 | Kellog Co | READY-TO-EAT CEREAL PRODUCT FORTIFIED WITH EDTA FERRICO COMPLEX AND METHOD FOR PRODUCING IT |
-
1998
- 1998-01-23 CN CN98100374A patent/CN1065726C/en not_active Expired - Fee Related
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100346725C (en) * | 2001-08-03 | 2007-11-07 | 卡夫食品集团公司 | Stable and bioavailable iron fortified beverages |
| CN101481319B (en) * | 2009-02-04 | 2011-12-14 | 北京维他科技有限公司 | Method for drying super-fine sodium iron ethylenediaminetetraacetate (NaFeEDTA) product capable of rapidly dissolvable |
| CN105837461A (en) * | 2015-01-17 | 2016-08-10 | 杨俊� | Production technology of high purity iron supplement agent sodium feredetate |
| CN111714470A (en) * | 2020-05-27 | 2020-09-29 | 天津瑞益瑞美生物技术有限公司 | Sustained-release ethylenediamine tetraacetic acid iron sodium premix for animals and preparation method thereof |
| CN111714470B (en) * | 2020-05-27 | 2022-04-08 | 天津瑞益瑞美生物技术有限公司 | Enteric-coated sodium iron ethylene diamine tetraacetate premix for livestock and preparation method thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1065726C (en) | 2001-05-16 |
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