CN1557459A - Euterma Wasabi contained medicine or health product - Google Patents
Euterma Wasabi contained medicine or health product Download PDFInfo
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- CN1557459A CN1557459A CNA2004100497345A CN200410049734A CN1557459A CN 1557459 A CN1557459 A CN 1557459A CN A2004100497345 A CNA2004100497345 A CN A2004100497345A CN 200410049734 A CN200410049734 A CN 200410049734A CN 1557459 A CN1557459 A CN 1557459A
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Abstract
The present invention relates to medicine and health article prepared with Euterma Wasabi. Fresh rhizoid, tuber, leaf and stem of Euterma Wasabi are used in preparing health care medicine for regulating human body's gastrointestinal function so as to treat chronic gastrointestinal tract diseases through the process of freeze drying, crushing, mixing, pelletizing and capsulizing; and the volatile oil and other components extracted from Euterma Wasabi are prepared into externally applied medicine with effects of diminishing inflammation and stopping pain.
Description
Technical field:
The present invention relates to a kind of Chinese medicine preparation or health product, particularly a kind of medicine or Halth-care composition and the application of said composition in treatment gastroenteropathy and adjusting gastrointestinal function that contains scurvy grass (Eutremawasabi).
Background technology:
Scurvy grass (Eutrema wasabi) is a Cruciferae scurvy grass platymiscium, has another name called Wasabia japonic (Euterma Wasabi), Radix Cochleariae officinalis, Alpinia japonica (Thunb.) Miq. etc.Orectic function was general in the past to be widely used in multiple flavoring agent as the hot fragrant material of going with rice or bread because it has, and in Japan, every country in Southeast Asia bigger application market is arranged.Because this plant has stronger pungent pungent taste, the crowd edible in China is very few.The inventor is by a large amount of investigation and experimentation, main component to this plant is analyzed, and finds that its main component is volatile oil (as alkylene isothiocyanate, straight chain fatty acid etc.), alkaloid, flavone, aminoacid, vitamin C, vitamin E and various trace element.
Summary of the invention:
The inventor studies the composition and the effect of scurvy grass, find that scurvy grass has stronger regulatory function to people's taste, strong sterilization arranged, kill the digestive system parasite, promote starchiness food digestion, stablize in the intestines and stomach effect such as vitamin C, the present invention finds that also scurvy grass can also have local analgesia, antiinflammation as the skin rubefacient in addition.
Taste are the smooth and easy normal physiological activity of human body of just keeping of " the foundation of acquired constitution " the two mechanism of qi, and the present invention finds the composition that scurvy grass possesses, and can be used as the drug use that gastrointestinal function is had the good health care effect.
The invention provides with scurvy grass and prepare a kind of medicine or health product for the treatment of gastroenteropathy and regulating gastrointestinal function, described gastroenteropathy comprises various gastritis, gastric ulcer, heartburn, gastric acid, flatulence, dyspepsia, constipation, irritable bowels syndrome, diarrhoea etc.
It is medicine or the Halth-care composition that raw material is made with the scurvy grass that the present invention also provides a kind of, said composition contains scurvy grass or its raw material or its activity extract through processing of 1-99%, said composition also can comprise the medicine acceptable carrier, and these medicine acceptable carriers can be: water, alcohol, Mel, starch, sucrose, lactose, caramel, mannitol, silicon derivative, cellulose family and derivant thereof, alginate, gelatin, polyvinylpyrrolidone, glycerol, soil temperature 80, agar, calcium carbonate, calcium bicarbonate, surfactant, Polyethylene Glycol, cyclodextrin, beta-schardinger dextrin-, the phospholipid material, Kaolin, Pulvis Talci, calcium stearate, magnesium stearate etc.
Scurvy grass of the present invention is that raw material refers to, uses wild or cultivates, and any position of the root of fresh or outmoded scurvy grass, palpus, tuber, leaf, handle or their combination in any or they lump together and are raw material.
Medicine of the present invention or Halth-care composition can be to take by oral or other modes.
Compositions of the present invention can be made the various dosage forms that are fit to take, and these dosage forms can be: tablet, sugar coated tablet, film coated tablet, enteric coated tablet, capsule, hard capsule, soft capsule, oral liquid, suck agent, granule, electuary, pill, powder, unguentum, sublimed preparation, suspensoid, powder, solution, injection, suppository, ointment, plaster, cream, spray, drop, patch.Compositions of the present invention, peroral dosage form preferably, as: capsule, tablet, oral liquid, granule, pill, powder, sublimed preparation, unguentum.Capsule most preferably, scurvy grass is that the active component that raw material is made is 1-1000mg in every capsules, other are medicine or health product acceptable carrier.
Compositions of the present invention can also contain the composition of other treatment gastroenteropathy effect, also can together take with the medicine of other treatment gastroenteropathy.
The present invention gives full play to scurvy grass monomer plant at mediator's gastrointestinal function and treat chronic gastroenteropathy and the effective ingredient that extracted is used for antiinflammatory, analgesic clinical treatment purposes.Scurvy grass is compared the characteristics that characteristic, curative effect are good and side effect is little that it possesses natural plants with the therapeutic efficiency of this field chemical drugs.
The present invention can adopt traditional preparation technology to prepare the raw material of scurvy grass compositions, also can adopt the advanced freeze-dry process technology preparation of modernization, and this preparation method can keep the cell originality of plant more fully.
The present invention is for solving strong pungent acid in the edible process of scurvy grass, and the technology that adopts powder granulation filling capsule is directly to cover the pessimal stimulation in the edible process.
The present invention also can carry out effective separation and Extraction with each functional part of scurvy grass, and with the active component of its extract as medicine, active component is carried by water or the preparation of conventional method such as alcohol extraction.
The present invention uses root, palpus, tuber, leaf, the handle of fresh scurvy grass to possess strong acid all can obtain effective ingredient such as equal volatile oil, flavone, aminoacid with its extraction respectively.
Because root hair, tuber, leaf, the handle of scurvy grass all possess identical effect and can separation and Extraction arrive identical effective ingredient, therefore the effective ingredient at arbitrary position is formed pharmaceutical composition as active component and will play equal effect.
Scurvy grass medicine material of the present invention and compositions can prepare by the following method:
With bright scurvy grass root, stem, the petiole arrangement classification of collecting, clean.
Be cut into fritter, dried feed is pulverized in lyophilization, and grinding and sieving adds medicine acceptable carrier mixing, encapsulated or pelletizing press sheet, or make preparation on the other drug.
Scurvy grass medicine material of the present invention also can prepare by the method for extracting its effective ingredient: get the scurvy grass rhizome, be cut into fragment, use water extraction, can get volatile oil component (as alkylene isothiocyanate, straight chain fatty acid etc.).
The water extract is filtered, get medicinal liquid I, the medicinal residues alcohol extraction boils off the pure medicinal liquid II of getting.Medicinal liquid I and medicinal liquid II are merged the macroporous adsorptive resins of back by having handled well, the water eluting, the pure eluting in back is collected alcohol eluen, and evaporate to dryness gets the macroporous resin adsorption thing, can get alkaloid and flavone component.
In addition, the positive exchange of particles resin column of medicinal liquid by having handled well, the water eluting, back ammonia eluting is collected the ammonia eluent, and evaporate to dryness gets positive particle resin absorption thing, can get aminoacid ingredient.
Thus can be with effective ingredient separation and Extraction such as volatile oil, alkaloid, flavone and aminoacid.
Make means through common preparation after the effective ingredient of said extracted mixes, can be made into the preparation on any materia medica.
Medicine of the present invention is by zoopery and people's clinical experiment, proof has the health care of spleen benefiting and stimulating the appetite, appetite stimulator, jiao dispelling cold and analgesia, anti-inflammation, loosening bowel to relieve constipation, and the effect that shows the good curing gastroenteropathy also has anti-inflammatory and analgesic effect simultaneously.
The specific embodiment:
Embodiment 1: the preparation of scurvy grass capsule
It comprises the following steps:
(1) the about 20kg arrangement of bright scurvy grass root, stem, the petiole that will collect classification is cleaned.
(2) be cut into the fritter that is about 2 centimetres with automatic medicine cutter.Put into II type freeze dryer, after putting-55 ℃ of lyophilization 24h, measuring its moisture content with KETT is 0.78% (requiring its water content below 1%) and for taking out after the light green color, receive dry product 3.6kg (requiring the 16%--18% of dry product yield) for wet product.
(3) dried feed is pulverized immediately, pulverized the back and cross 100 mesh sieves.
(4) in the fine powder that obtains, add about 450g lactose, about 450g starch, Diluted Alcohol (ratio of ethanol and water is 1: 1, and dissolving ethyl hydroxybenzoate 3.6g) in right amount, with the equivalent principle mix homogeneously that progressively increases, the granulation of 24 mesh sieves.
(5) in 60 ℃ of dry back granulate, with the equivalent principle mix homogeneously that progressively increases.Filling capsule, average every heavy 0.5g behind the cleaning capsule outside, uses the silicone oil polishing.Get finished product by each PVC bottle 50 particle packing.
Embodiment 2: the freeze drying technology of fresh scurvy grass
(1) bright scurvy grass classification arrangement back drip washing is clean, be cut into the fritter that is about 2 centimetres.
(2) with the little II type freeze dryer that places soon, in-55 ℃ of lyophilizing.
(3) measure its water content 1% when following, take out.
(4) pulverize, cross 100 mesh sieves.
Embodiment 3: the extraction separation of scurvy grass effective site.Separation to the scurvy grass effective ingredient can be adopted following steps:
(1) gets scurvy grass rhizome (380g), be cut into fragment.
(2) fragment is placed 2000ml flask extracting in water, can get volatile oil (as alkylene isothiocyanate, straight chain fatty acid etc.).
(3) the water extract is filtered, medicinal liquid I, medicinal residues are with 70% alcohol reflux twice, decompression recycling ethanol gets medicinal liquid II.Medicinal liquid I and medicinal liquid II are merged, mixing (1500ml), standby.
(4) get above-mentioned medicinal liquid 500ml, by the macroporous adsorptive resins of having handled well, water is eluted to colourless, uses 70% ethanol elution instead, collects ethanol elution, and evaporate to dryness gets the macroporous resin adsorption thing, can get alkaloid and flavone etc.
(5) taking liquid 50ml in addition, by the positive exchange of particles resin column of having handled well, water is eluted to neutrality, uses 5% ammonia eluting instead, collects the ammonia eluent, and evaporate to dryness gets positive particle resin absorption thing, can get aminoacid.
Thus can be with separation and Extraction in addition such as volatile oil, alkaloid, flavone and aminoacid.
Embodiment 4: the scurvy grass lyophilized powder is to the therapeutical effect of mice reserpine type gastric ulcer
Experiment material:
(1) tried thing
Title: the scurvy grass lyophilized powder, provide by Kangerwei Pharmaceutical Co., Ltd., Chongqing,
Content; Every g scurvy grass lyophilized powder equals crude drug in whole 1g
Compound method: take by weighing sample 10g adding distil water and make every ml contain the about 0.14g of crude drug to 70ml
Route of administration: gavage administration.
(2) moulding and reference substance
Reserpine is produced by Shanghai red flag pharmaceutical factory, lot number 20010325, and cimetidine is produced by southwestern pharmaceutcal corporation, Ltd, lot number 20010521
(3) laboratory animal: kunming mice, one-level animal (lot number: the moving word the 310101001st of doctor) provide by Animal Experimental Study chamber, Chongqing Institute of Chinese Medicine.
(4) experimental situation
Experiment is carried out at the primary standard Animal Lab., No. 20000330, the facility certificate of competency.
Experimental technique: kunming mice, body weight 18～22g, the male and female dual-purpose is divided equally 5 groups at random: (N=10) NS group, J-2002 ulcer medicated powder 5.7g crude drug/kg, 2.86g crude drug/kg, 1.43g crude drug g/kg and cimetidine 500mg/kg, medicine group ip every day was administered once continuous 7 days, after the 6th administration, after fasting 24h, the administration in the 7th day, every Mus sc reserpine 10mg/kg; Put to death animal after 6 hours, get the stomach formaldehyde fixed, calculate the ulcer of glandular stomach portion appearance and count, data are through the t inspection statistics.
Experimental result; See Table 1
Table 1 scurvy grass lyophilizing medicated powder is to the therapeutical effect of mice reserpine type gastric ulcer
| Group dosage g/kg number of animals ulcer is counted |
| ????NS??????????????????10????11.60±2.10 |
| Scurvy grass lyophilized powder 5.7 10 8.30 ± 3.23 |
| Scurvy grass lyophilized powder 2.86 10 10.00 ± 3.70 |
| Scurvy grass lyophilized powder 1.43 10 10.60 ± 3.50 |
| Cimetidine 0.5 10 7.50 ± 1.84 |
Conclusion: the result shows that J-2002 ulcer medicated powder 5.7g/kg has therapeutical effect p＜0.05 to mice reserpine type gastric ulcer.
Embodiment 5: the preliminary clinical observation on the therapeutic effect of scurvy grass capsule oral treatment chronic digestible tract disease.
(1) test director: the Wang Jin of the People's Hospital is clear for the Nan'an District, Chongqing City
(2) prerun purpose: for estimating the effectiveness and the safety of scurvy grass to chronic gastritis.
(3) test method: this test is the clinical research of parallel control at random.Have 32 (16 couples) experimenters enter this research by random assortment to test group (scurvy grass) and placebo group.Behind the subject enrollment, research worker will be obtained data such as experimenter's medical history, gastrointestinal function base case, and carry out conventional physical examination, lab testing, to determine whether the experimenter meets inclusion criteria, begin in the first two week to withdraw the medicine of any other treatment gastrointestinal tract illness from testing to the off-test experimenter.Selected back experimenter by random assortment enter 8 weeks the treatment phase (investigational agent: the scurvy grass capsule, specification 0.5g/ grain is provided by Kangerwei Pharmaceutical Co., Ltd., Chongqing; Placebo: outward appearance, dosage form are consistent with investigational agent, are provided by Kangerwei Pharmaceutical Co., Ltd., Chongqing.) research worker should instruct experimenter's correctly taking drugs, every experimenter takes three every day, each three, serve on for 8 weeks.Respectively at arranging to make a house call for three times the 2nd, 4,8 weekends after the treatment, observe safety and effectiveness therebetween.When the 0th week (stage of preparation) and the 8th weekend, research finished, check the improvement situation of experimenter's gastrointestinal function.
(4) result of the test: see Table two
Table two: the scurvy grass capsule is to antral gastritis patient's treatment situation
Conclusion: it is 87.5% that the scurvy grass capsule has good safety and acceptable clinical total effective rate, apparently higher than placebo group, is a kind of medicine of effective treatment antral gastritis.
Embodiment 6: the treatment of gastropathy
Model case (one)
Patient king * *, the male, 42 years old, the driver had the gastric and duodenal ulcers medical history 16 years, and no ulcerative hemorrhage history did once that the stomach pylorus is made a definite diagnosis in gastroscopy and duodenum respectively has a ulcer.Take multiple Chinese and Western stomach medicine once, all do not have significant curative effect.Cause appetite decline a few days ago, comparatively obvious after big belly is particularly taken food.Because hypoalimentation causes health obviously to be become thin.Simultaneously with obviously halitosis and constipation.
From beginning to take the scurvy grass capsule, specification 0.5g/ grain, every day three each two one after each meals.Subjective symptoms takes an evident turn for the better behind the first quarter moon.Mainly show: taking medicine after the feed, it is bloated no longer to occur going up clothes, and tangible hunger sensation is arranged, and appetite increases to some extent, and halitosis disappears, free movement of the bowels.The patient wishes to continue to take this product.Period in a medicine does not have any untoward reaction.
Model case (two)
The patient relaxes * *, the male, 30 years old, the company clerk had stomach discomfort, and sensation of fullness was after the meal once done gastroscopy before surplus in the of 10 year, made a definite diagnosis chronic superficial gastritis, once took multiple Chinese and Western stomach medicine, the remission instability.
Taking this product, to reach February surplus, every day 3 times, and each 2, to take after the meal, conscious stomach discomfort sense is obviously alleviated, and appetite heightens, and free movement of the bowels still adheres to taking this medicine at present.No any untoward reaction during taking.
Model case (three)
The patient opens * *, the male, 37 years old, the salesman suffered from chronic enteritis 5 years, often epigastric pain, indigestion and loss of appetite, diarrhoea, above-mentioned symptom aggravation after taking pungent stimulation food.Once took multiple Chinese medicine and western medicine, poor effect during one's sickness.
Taking this product continuously after 4 months (, take after the meal every day 3 times by each 2), function of intestinal canal makes moderate progress, and to the tolerance enhancing of pungent excitant food, diarrhoea stops, and the gastral cavity abdominal pain disappears.Still adhere to taking this medicine at present.No any untoward reaction during taking.
Embodiment 7: anti-inflammatory and analgesic effect
Model case (one)
Patient male, 45 years old now, because of traffic accident causes chest soft tissue contusion, hinder the back and obvious chest pain occurs, more obvious during breathing, X-ray examination, left breast 9-11 rib line style fracture, dislocation-free, no hemopneumothorax X line sign, clothes anti-inflammatory analgesic anti symptom treatment, mastery.
Hindered the back the 3rd day, root hair, tuber, leaf, the handle with fresh scurvy grass mashes respectively, is applied to the injury, repeatedly wrapping.Obvious skin irritation appears in the patient injury behind half novel, medicine is removed found that medication place skin is obviously rubescent, and no blister forms, and the conscious injury of patient on that night pain is obviously alleviated, treated continuously three days, since bigger to skin irritation, stop using.Total cognition is covered with tangible analgesic effect outward with fresh scurvy grass.
Model case (two)
Patient male, 42 years old, the right upper extremity wrist was sprained, local livid purple congestion, swelling pain, function limitation, hindered back second day, the volatile oil component 5ml that fresh scurvy grass petiole is extracted mixes with tetracaine hydrochloride 1ml and spreads on the affected part, inspection cleaning half an hour, local skin is observed and is seen that illing skin is rubescent, but the patient is conscious no abnormal, and the local pain symptom has obvious alleviation after 2 hours, once a day later on, up to recovery from illness, the patient does not obey the analgesic drug basically again during the treatment.The patient thinks that this medicine has tangible analgesic effect
Embodiment 8: the scurvy grass preparation tablets
Get the scurvy grass fine powder 100g after the pulverizing among the embodiment 1, add starch 50g, carboxymethyl cellulose 50g, 75% ethanol are wetting agent, mixing, wet granulation, oven dry, granulate add 1% magnesium stearate, the mixing tabletting extrudes 200, and every contains scurvy grass fine powder 0.5g.
Embodiment 9: the preparation of scurvy grass sugar coated tablet
The sheet of embodiment 8, it is red an amount of to add Pulvis Talci, syrup, bamboo water pipe, makes 200 coated tablets with the coating pan sugar coating.
Embodiment 10: be the preparation of the capsule of active component with the scurvy grass extract
The volatile oil that the method for embodiment 3 is extracted, alkaloid, flavone and aminoacid take by weighing 100g after mixing.With starch 50g, lactose 50g, magnesium stearate 2g mixing, encapsulated 1000.
Claims (9)
1. scurvy grass or to be the medicine made of raw material or Halth-care composition with the scurvy grass treat gastroenteropathy, regulate gastrointestinal function and have the medicine of anti-inflammatory and analgesic effect or the application in the health product in that preparation is a kind of.
2. the application of claim 1 is characterized in that, described scurvy grass is medicine or the Halth-care composition that raw material is made, and is meant that with the scurvy grass activity extract be medicine or the health product that active component is made.
3. the application of claim 2 is characterized in that, wherein said activity extract is meant the scurvy grass process extract that water is carried or alcohol extraction is made.
4. medicine or Halth-care composition is characterized in that, its active component is is raw material with the scurvy grass through water is carried or alcohol extraction is made extract.
5. the compositions of claim 4 is characterized in that, the described extract of obtaining through refining through water contains volatile oil component.
6. the compositions of claim 4 is characterized in that, the described extract of obtaining through refining through water also contains alkaloid, flavone, aminoacid ingredient.
7. the preparation of compositions method of claim 4 is characterized in that, through following steps, gets the scurvy grass rhizome, is cut into fragment, uses water extraction, gets volatile oil component.
8. the preparation of compositions method of claim 7 is characterized in that, also passes through following steps, and the water extract is filtered, and gets medicinal liquid I, and the medicinal residues alcohol extraction boils off the pure medicinal liquid II of getting; Medicinal liquid I and medicinal liquid II are merged the macroporous adsorptive resins of back by having handled well, the water eluting, the pure eluting in back is collected alcohol eluen, and evaporate to dryness gets macroporous resin adsorption thing alkaloid and flavone component.
9. the preparation of compositions method of claim 7 is characterized in that, also passes through following steps, and the water extract is filtered, and gets medicinal liquid I, and the medicinal residues alcohol extraction boils off the pure medicinal liquid II of getting; Medicinal liquid I and medicinal liquid II are merged the positive exchange of particles resin column of back by having handled well, the water eluting, back ammonia eluting is collected the ammonia eluent, and evaporate to dryness gets positive particle resin absorption thing, gets aminoacid ingredient.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2004100497345A CN1557459A (en) | 2002-08-08 | 2002-08-08 | Euterma Wasabi contained medicine or health product |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2004100497345A CN1557459A (en) | 2002-08-08 | 2002-08-08 | Euterma Wasabi contained medicine or health product |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 02125993 Division CN1408405A (en) | 2002-08-08 | 2002-08-08 | Medicne or health article containing behen vegetable |
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| Publication Number | Publication Date |
|---|---|
| CN1557459A true CN1557459A (en) | 2004-12-29 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNA2004100497345A Pending CN1557459A (en) | 2002-08-08 | 2002-08-08 | Euterma Wasabi contained medicine or health product |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102920801A (en) * | 2012-11-29 | 2013-02-13 | 井冈山大学 | Traditional Chinese medicine preparation for treating gastropathy |
| CN109699685A (en) * | 2019-01-15 | 2019-05-03 | 深圳市淳睿贸易有限公司 | Antibiotic slice, antibacterial agent and its application |
-
2002
- 2002-08-08 CN CNA2004100497345A patent/CN1557459A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102920801A (en) * | 2012-11-29 | 2013-02-13 | 井冈山大学 | Traditional Chinese medicine preparation for treating gastropathy |
| CN102920801B (en) * | 2012-11-29 | 2013-12-25 | 井冈山大学 | Traditional Chinese medicine preparation for treating gastropathy |
| CN109699685A (en) * | 2019-01-15 | 2019-05-03 | 深圳市淳睿贸易有限公司 | Antibiotic slice, antibacterial agent and its application |
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