CN1088365C - Medicine for curing infectious gastrosis and its preparing process - Google Patents
Medicine for curing infectious gastrosis and its preparing process Download PDFInfo
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- CN1088365C CN1088365C CN00111095A CN00111095A CN1088365C CN 1088365 C CN1088365 C CN 1088365C CN 00111095 A CN00111095 A CN 00111095A CN 00111095 A CN00111095 A CN 00111095A CN 1088365 C CN1088365 C CN 1088365C
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- fructus evodiae
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Abstract
The present invention provides a medicine for treating infective gastropathy and a preparation method. The medicine is prepared from raw materials of the following proportion by weight: 5 to 20 of dock root, 5 to 20 of dandelion, 2 to 15 of coptis, 2 to 15 of baical skullcap root, 0.5 to 5 of dried ginger, 0.5 to 5 of medicinal evodia fruit and 1 to 5 of licorice root. After the coptis, the baical skullcap root, the dried ginger, the medicinal evodia fruit and the licorice root are crushed and sieved, sieved crude powder is extracted by dilute ethene solution, the dock root and dandelion are decocted by a decocting method, filter liquor is concentrated, and the concentrated filter liquor, fine powder and an extract which are prepared by the steps a and b, and pharmacy starch are mixed and sterilized to prepare the medicine for treating gastropathy.
Description
The present invention relates to a kind of medicine for the treatment of infected gastric disease, is to be the medicine of feedstock production with the Chinese herbal medicine specifically, the invention still further relates to the preparation method of this medicine.
Gastropathy is common clinical, and among the people have saying of " ten people, nine stomaches ", and chronic gastritis and peptic ulcer are the main diseases kinds of gastropathy.Modern scientific research confirms, helicobacter pylori be chronic gastritis main diseases because of, closely related with degree, activeness and intractable and the recurrent of the morbidity of peptic ulcer, pathological changes.Helicobacter pylori especially has the recall rate of very high (80~90%) at peptic ulcer in the patient of duodenal ulcer.Also the someone proves, when the gastroscopy helicobacter pylori was turned out cloudy, ulcer also healed, and draws the conclusion of " no helicobacter pylori does not have ulcer " to the greatest extent, and helicobacter pylori also is proved to be to cause the arch-criminal of gastric cancer.According to statistics, the helicobacter pylori crowd infection rate is in developed country about 40~50%, in developing country up to more than 70%, though at the not authoritative statistical data of China, but because of digestive system disease death person comes the 6th of resident's cause of the death cis-position, gastric cancer mortality comes the mortality of malignant tumors precedent, this shows that relevant gastropathy with helicobacter pylori infections is the healthy important diseases of serious harm people.
Helicobacter pylori is all very responsive to most antibiotics and other medicines; therefore; the medical worker treats simple use acid inhibitor and gastric mucosa protectant and changes preferential use antibiotic into; but because helicobacter pylori colonizes in the human stomach mucous layer; constantly the stomach of wriggling makes these medicines too short in the gastric time of staying; more be difficult for penetrating the gastric mucosa layer, be difficult to play the effect that suppresses and kill helicobacter pylori.Therefore, though the antibiotic kind is many, be not all to be suitable for treating infectious peptic ulcer and chronic gastritis clinical.At above-mentioned situation, the medical worker has selected the antibiotic peroral dosage form, but because this type of disease of treatment is longer the course of treatment, these medicines have intensive digestive tract to stimulate and to the untoward reaction of other system, make the patient very poor to the compliance of medicine, anaphylaxis and granulocytopenia as penicillin, the gastrointestinal reaction of tetracycline, the toxic encephalopthy of bismuth and acute renal failure (some country prohibites the anemia of pregnant woman and the child uses bismuth), the digestive system of metronidazole and the untoward reaction of neural psychiatric system, gentamycin is to infringement of Liver and kidney etc.
One of purpose of the present invention provides a kind of evident in efficacy, reduces relapse rate, the medicine of the treatment infected gastric disease that has no side effect.It is simple that two of purpose provides a kind of technology that one of achieves the goal, the preparation method of the medicine of easy operating.
One of purpose of the present invention can realize by following measure:
Medicine of the present invention is made by following component: (consumption is a weight portion)
Radix Rumicis 5~20 Herba Taraxacis 5~20
Rhizoma Coptidis 2~15 Radix Scutellariaes 2~15
Rhizoma Zingiberis 0.5~5 Fructus Evodiae 0.5~5
Radix Glycyrrhizae 1~5
Formula optimization weight (part) ratio range of preparation medicine of the present invention is:
Radix Rumicis 5~15 Herba Taraxacis 5~15
Rhizoma Coptidis 3~10 Radix Scutellariaes 3~10
Rhizoma Zingiberis 0.5~2 Fructus Evodiae 0.5~2
Radix Glycyrrhizae 2~5
The optimum weight of medicine of the present invention (part) proportioning is:
Radix Rumicis 10 Herba Taraxacis 6
Rhizoma Coptidis 6 Radix Scutellariaes 6
Rhizoma Zingiberis 1 Fructus Evodiae 1
Radix Glycyrrhizae 1
The said dosage form of the present invention is a said dosage form on any pharmaceutics: said pharmaceutical formulation is a preferred version with capsule or electuary.
Above-mentioned each component is made medicine production method of the present invention is:
A, get Rhizoma Coptidis, Radix Scutellariae, Rhizoma Zingiberis, Fructus Evodiae, Radix Glycyrrhizae and pulverize, cross 200 mesh sieves, fine powder is standby:
B, the coarser powder that sifts out in a operation is extracted with Diluted Alcohol solution, discard residue, extracting solution is condensed into extractum after reclaiming ethanol;
C, Radix Rumicis, Herba Taraxaci were decocted 0.5~2 hour with decocting method, filter, filtrate concentrates the back mix with an amount of pharmaceutical purpose starch of fine powder, extractum and the adding routinely of a, the preparation of b operation and sterilize after, make capsule or electuary.
Medicine of the present invention is to get " 0 " number capsule through disinfection by ultraviolet light, and fill in Drug Manufacturing Room is adorned 0.3 gram for every, contains crude drug in whole 0.6 gram, and 100 of every packings are put the sterilization of cobalt Room 60 then.
The present invention is intended to utilize the natural pharmaceutical resources in the Nature, and the medicine that reaches the clinical cure purpose and reduce relapse rate and have no side effect is provided for the patient who suffers from infected gastric disease.The present invention is made up of Radix Rumicis, Rhizoma Coptidis, Radix Scutellariae, Herba Taraxaci, Rhizoma Zingiberis, Fructus Evodiae, Radix Glycyrrhizae, and Radix Rumicis is monarch in the side, and Rhizoma Coptidis, Radix Scutellariae, Herba Taraxaci are minister, assistant Rhizoma Zingiberis, Fructus Evodiae.Radix Rumicis, Rhizoma Coptidis, Radix Scutellariae, Herba Taraxaci have heat-clearing and toxic substances removing, dampness pathogenic fire purging effect in the prescription, and modern study shows can be antibacterial, antiinflammatory, antiulcer.Modern pharmacology is tested known Rhizoma Coptidis, Radix Scutellariae, Herba Taraxaci has stronger bactericidal action to HP.The single Radix Rumicis has good anastalsis, finds also that through clinical observation on the therapeutic effect HP is had strong killing action, and in addition, Radix Rumicis, Herba Taraxaci all have the promoting tissue regeneration by removing blood stasis effect.Herba Taraxaci strengthens the effect of immune function of human body in addition.Radix Glycyrrhizae invigorating the spleen and regulating the stomach, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription are for making, and the modern study Radix Glycyrrhizae also has the effect of killing HP, and mediator's body immunity function preferably.Modern study confirms that Rhizoma Zingiberis, Fructus Evodiae all have the effect of killing HP, and all be apt to emesis.Fructus Evodiae, Rhizoma Zingiberis are got the meaning of its using corrigent in prescription, formulate appropriate proportioning, make cold gram to some extent; heat has made; not only removed helicobacter pylori but also can press down acid protection gastric mucosa, can suit the medicine to the illness and can to because of, reach the purpose of infectious chronic gastritis of radical cure and peptic ulcer.
Observations and method
The checking case is totally 76 examples, and the case source is outpatient service.Observation group's 50 examples wherein, matched group 26 examples.Maximum 65 years old age of observation group, minimal ages 19 years old, 32.6 ± 5.57 years old mean age, the course of disease is the shortest 6 months, the longest 15 years, average course of disease 38.3 ± 7.4, matched group, maximum 63 years old age, minimal ages 19 years old, 30.9 ± 6.52 years old mean age, the course of disease is the shortest 6 months, the longest 13 years, average course of disease 36.1 ± 5.9 months (seeing Table 1. tables 2).
Table 1: two groups of case age distribution tables
Age (year) 10~20~30~40~50~60~
Observation group 1 11 8 15 10 5
246743 liang of groups of matched group are no significant difference relatively, has comparability.
Table 2: two groups of course of disease distribution tables
The course of disease (year) 0~1~2~3~4~
Group
Observation group 77 11 16 9
Matched group 34676
(1) checking case choice criteria
1, tcm diagnosis standard
Clinical symptoms, diagnostic criteria is with reference to " the clinical research guideline of new Chinese medicine treatment gastropathy gastralgia " of Ministry of Public Health promulgation in 93 years.
(1), gastral cavilty portion pain and gastrointestinal disease symptom;
(2), history of repeated attack is arranged;
(3), premorbid has the obvious cause of disease more.
Above-mentioned (1) must possess, and should have concurrently all the other 1~2 promptly diagnosable.
2, Western medicine diagnose standard
All cases are all done gastroscopy, and pathological replacement and rapid urease test are diagnosed as peptic ulcer and chronic gastritis due to the helicobacter pylori infections.
3, get rid of the case standard
(1), malignant tumor and patient with surgery situation.
(2), the age is at under-18s or over-65s, gestation or women breast-feeding their children.
(3), be associated with serious recurrent disease such as cardiovascular, liver, kidney and hemopoietic system, psychotic.
(4), do not meet the standard of including in, not medication in accordance with regulations can't be judged that curative effect or data are not congruent to affect the treatment or safety judgement person.
(2) Therapeutic Method
Observation group's medicine of the present invention, every heavy 0.3 gram contains crude drug in whole 0.6 gram, each 4, every day 3 times is oral, half an hour ante cibum clothes, matched group is with the each bag of bismuth potassium citrate electuary (beautiful pearl pharmaceutical factory produce lot number, 9904087), whenever comprise bismuth 110mg, every day 3 times is oral, and be one month two groups of courses of treatment, stop using in other during the treatment, western drug, finish a course of treatment, and gastroscope, pathology and HP urease detected with interior check in 3 days.
(3) Clinical results
1, criterion of therapeutical effect:
Efficacy determination reverts to main foundation with the cloudy gastric mucosal lesion that changes of helicobacter pylori (HP).Cure: HP is cloudy to be changeed, and it is normal that gastroscope and pathologic finding mucosa recover, clinical symptom disappearance.Produce effects: HP is cloudy to be changeed, and the pathological changes mucosa recovers normally substantially, and symptom obviously alleviates.Take a turn for the better: cloudy commentaries on classics of HP or strong positive change weak negative, and pathological changes mucosa scope dwindles 2/3, and the inflammation degree alleviates, clinical symptom relief.Invalid: HP pathological changes mucosa and clinical symptoms all do not have improvement.
2, result:
50 examples are organized in treatment, cure 27 examples (accounting for 54%), produce effects 10 examples (accounting for 20%), and 8 examples that take a turn for the better (accounting for 16%), invalid 5 examples (accounting for 10%), total effective rate is 90%.Matched group 26 examples are cured 5 examples (accounting for 19.23%), produce effects 4 examples (accounting for 15.38%), and 5 examples that take a turn for the better (accounting for 19.23%), invalid 12 examples (accounting for 46.16%), total effective rate is 53.84%.There were significant differences (p<0.01) in contrast between two groups.
Table 3: two groups of total effects comparison sheets
Curative effect is cured the produce effects invalid total that takes a turn for the better
Observation group 27 10 85 50
Light statistical procedures p<0.01 between 545 12 26 liang of groups of matched group, observation group obviously is better than matched group.
Preparation method of the present invention is simple, easy operating, and producing cost is low, only makes water and ethanol (recyclable) in the preparation process.Medicine of the present invention is a pure Chinese medicinal preparation, and it is very favourable that the hyperemia of elimination gastric mucosa, edema, erosion, promotion ulcer surface are healed, and do not have other any chemicals and toxic and side effects.The present invention can be damaged the basic all propositions of the effective nutritional labeling in the raw material, and concentration is big, makes things convenient for the patient to take and absorbs, and there is no any misery, can significant especially therapeutical effect be arranged to infected gastric disease.
Medicine of the present invention, usual amounts are every day three times, and each five, one month is a course of treatment.
Model case:
1, public * *, woman, 25 years old, peasant.Because of the epigastrium distending pain, hiccough etc. come outpatient service to go to a doctor on January 12nd, 2000.Gastroscopy stomach prepyloric region is mucosa moderate activeness inflammatory and changes, and is diagnosed as chronic gastritis; Pathological section, the agglomerating II level that exists of helicobacter pylori under the mirror; The mould quick diagnosis result of the test of carbamide ++: be diagnosed as infectious chronic gastritis.Medicine of the present invention is taken in order, and each five, three times on the one, serve on one month, avoid and drink and pungent and sweet excessively, peracid ingesta, check on the 3rd after the drug withdrawal, clinical symptom disappearance, weight increase is 3,5 kilograms in the readme moon, mild inflammation is shown in gastroscopy, pathological section, and the down no helicobacter pylori of mirror is found, the mould quick diagnosis test of carbamide is negative, obtains clinical recovery.
2, Lee *, man, 32 years old, cupboard teacher.Because of epigastrium dull pain, on an empty stomach benefit very, pantothenic acid is heartburn, the time black stool is arranged, lack of appetite is weak, with coming outpatient service to go to a doctor.Patient's readme has this symptom to have a surplus in 1 year, is diagnosed as chronic gastritis at county hospital and merges duodenal ulcer.Never be interrupted treatment, once used the west flavor for fourth, bismuth pectin motilium, gastritis electuary etc., the fashion time difference, outbreak repeatedly.Through the gastroscopy of reforming, gastric antrum portion mucous hyperemia edema is slight rotten to the corn, pyloric cap has the big niche of beans, and there are the III level in flakes in pathological section, helicobacter pylori, the mould quick diagnosis result of the test of carbamide +++, be diagnosed as infectious chronic gastritis, duodenal ulcer.Order clothes medicine of the present invention, each five, three times on the one, serve on one month after further consultation, clinical symptoms disappears substantially, the period in a medicine idol has diarrhoea, gastroscopy, gastric mucosa recover normally substantially, and pyloric cap niche area dwindles more than 60%, two level degree of pathological section decline, the mould quick diagnosis test of carbamide is the weak positive.Advising decrement is 4 of each clothes, three times on the one, continues and obeys 15, the back check of one week of drug withdrawal, gastroscopy gastric inflammation and pyloric cap niche all disappear, and do not find helicobacter pylori under the pathological section mirror, the mould quick diagnosis result of the test of carbamide is negative, and obtains clinical recovery.
Embodiment:
Take by weighing raw material (kilogram) by following proportioning:
Radix Rumicis 12,5 Herba Taraxacis 12,5
Rhizoma Coptidis 5 Radix Scutellariaes 5
Rhizoma Zingiberis 2,5 Fructus Evodiaes 2,5
Radix Glycyrrhizae 2,5
Production method is as follows:
A, get Rhizoma Coptidis, Radix Scutellariae, Rhizoma Zingiberis, Fructus Evodiae, Radix Glycyrrhizae and pulverize, cross 200 mesh sieves, it is standby to collect thin medicated powder;
B, chieftain's (being coarser powder) of sifting out in a operation is added 50%7 alcohol, it is standby to make alcohol system extractum with alcohol extracting method;
C, Radix Rumicis, Herba Taraxaci were decocted one hour with decocting method, filter, filtrate is condensed into that to be similar to the extract sample standby;
An amount of pharmaceutical purpose starch mixing of d, the thin medicated powder with a, b, the preparation of c operation, extractum, extract and adding is routinely also made fine grained;
E, get " 0 " number capsule through disinfection by ultraviolet light, fill in Drug Manufacturing Room is adorned 0,3 grams for every, contains crude drug in whole 0,6 grams, and 100 of every packings are labelled after package encapsulation is good and put cobalt Room 60 and sterilize, thereby make capsule of the present invention.
Claims (6)
1, a kind of medicine for the treatment of infected gastric disease is characterized in that it is the medicament that has the following weight proportion raw material to make
Radix Rumicis 5~20 Herba Taraxacis 5~20
Rhizoma Coptidis 2~15 Radix Scutellariaes 2~15
Rhizoma Zingiberis 0.5~5 Fructus Evodiae 0.5~5
Radix Glycyrrhizae 1~5
2, the medicine of treatment infected gastric disease according to claim 1, wherein the weight proportion of each raw material is
Radix Rumicis 5~15 Herba Taraxacis 5~15
Rhizoma Coptidis 3~10 Radix Scutellariaes 3~10
Rhizoma Zingiberis 0.5~2 Fructus Evodiae 0.5~2
Radix Glycyrrhizae 2~5
3, the medicine of treatment infected gastric disease according to claim 1, wherein the weight proportion of each raw material is
Radix Rumicis 10 Herba Taraxacis 6
Rhizoma Coptidis 6 Radix Scutellariaes 6
Rhizoma Zingiberis 1 Fructus Evodiae 1
Radix Glycyrrhizae 1
4,, it is characterized in that said medicament is a said dosage form on any pharmaceutics according to the medicine of claim 1,2 or 3 described treatment infected gastric diseases.
5, the medicine of treatment infected gastric disease according to claim 4 is characterized in that said medicament is capsule or electuary.
6, the preparation method of the medicine of the described treatment infected gastric disease of claim 5 is characterized in that
A, get Rhizoma Coptidis, Radix Scutellariae, Rhizoma Zingiberis, Fructus Evodiae, Radix Glycyrrhizae and pulverize, cross 200 mesh sieves, fine powder is standby;
B, the coarser powder that sifts out in a operation is extracted with Diluted Alcohol solution, discard residue, extracting solution is condensed into extractum after reclaiming ethanol:
C, Radix Rumicis, Herba Taraxaci were decocted 0.5~2 hour with decocting method, filter, filtrate concentrates the back mix with an amount of pharmaceutical purpose starch of fine powder, extractum and the adding routinely of a, the preparation of b operation and sterilize after, make capsule.
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CN00111095A CN1088365C (en) | 2000-04-30 | 2000-04-30 | Medicine for curing infectious gastrosis and its preparing process |
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CN00111095A CN1088365C (en) | 2000-04-30 | 2000-04-30 | Medicine for curing infectious gastrosis and its preparing process |
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CN1088365C true CN1088365C (en) | 2002-07-31 |
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Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
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CN1075090A (en) * | 1993-01-09 | 1993-08-11 | 朝阳市第二医院 | Treatment chronic gastritis Chinese medicine stomachic tablet and preparation method thereof |
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Publication number | Priority date | Publication date | Assignee | Title |
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CN1075090A (en) * | 1993-01-09 | 1993-08-11 | 朝阳市第二医院 | Treatment chronic gastritis Chinese medicine stomachic tablet and preparation method thereof |
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