CN1557440A

CN1557440A - Medicinal capsule of

Info

Publication number: CN1557440A
Application number: CNA2004100218169A
Authority: CN
Inventors: 柱曹; 曹柱
Original assignee: Individual
Current assignee: Individual
Priority date: 2004-02-11
Filing date: 2004-02-11
Publication date: 2004-12-29

Abstract

The soft common lamiophlomis capsule is prepared with the extractive of root and rhizome of common lamiophlomis as one labiatae plant. The medicine has the functions of promoting blood circulation to disperse blood clots, relieving pain and arresting hemorrhage. It is used in treating post-operation pain, bleeding, trauma, fracture, dysmenorrhea, etc. and the capsule is easy to swallow and easy to absorb, and has contained medicine stable and less polluted. During its production, accurate liquid phase chromatographic method is adopted to replace spectrophtometery method to detect rutin content, and this is favorable to raising medicine product quality.

Description

Duyiwei soft capsule and preparation method thereof

Technical field: the present invention is a kind of Duyiwei soft capsule and preparation method thereof, belongs to the field of traditional Chinese medicine technology.

Background technology: Radix Lamiophlomidis Rotatae: be the root and rhizome or the herb of the capable section of lip plant Radix Lamiophlomidis Rotatae.This product is former to be recorded in " Sichuan Chinese medicinal herbal " and " Qinghai-Tibet medicine illustrated handbook ", and in 1987, Sichuan Province Department of Public Health " Sichuan Province's Chinese crude drug quality standard " was loaded with this product.Hide name: big bus, claim three watts again, cure gunshot wound with it, single uses has unique curative effect, so name.Its function cure mainly for: invigorate blood circulation, clots absorbing, pain relieving, the detumescence; Be used for traumatic injury, fracture, is sprained or the like waist; Useful its is prepared into the product of loose powder agent in the prior art; But the product of in use finding this class dosage form carries, uses, stores equal inconvenience, and production technology is simple in addition, and restive product quality is so influence the curative effect of medicine.

The objective of the invention is to: a kind of Duyiwei soft capsule and preparation method thereof is provided, and this product is that Radix Lamiophlomidis Rotatae is prepared into the preparation that needs, and is convenient to the patient and carries, takes and keeping, the storage of medicine; The present invention also provides the preparation method of this pharmaceutical preparation simultaneously, and the medicine that this method obtains, mass ratio are easier to control, and effective ingredient also is easy to detect.

The present invention constitutes like this: Duyiwei soft capsule: it is the made soft capsule preparation of dry root and rhizome extract with Labiatae Radix Lamiophlomidis Rotatae platymiscium Radix Lamiophlomidis Rotatae.Described soft capsule preparation is also: oral liquid, drop pill, granular preparation.The preparation method of this Duyiwei soft capsule is: get Radix Lamiophlomidis Rotatae, pulverize and be coarse powder, decoct with water, obtain extractum, drying is with the broken preparation that becomes to need for the fine powder refabrication of dried cream powder.More concrete say: get Radix Lamiophlomidis Rotatae 1000g, pulverize and be coarse powder, adds 10 times of water gagings and decoct 3 times, each 1 hour, collecting decoction, filtration, it is 1.25-1.30 (60 ℃ of-80 ℃ of surveys) that filtrate is concentrated into relative density.Dry below 80 ℃.With dried cream powder broken be fine powder (cross 100 mesh sieves), adds 1 times and measures soybean oil, 0.02 times of Cera Flava, mixing is pressed into 1000 soft capsules promptly.

Compared with prior art, this product has promoting blood circulation and stopping pain, changes silt hemostatic function; Be used for the edge of a knife pain behind the multiple surgical operation, hemorrhage, exogenous injury, muscles and bones is sprained, rheumatic arthralgia and sprout leakage, dysmenorrhea, gingival swelling and pain, hemorrhage etc., because this product special effect, clinical use is existing to be confirmed, change this product into soft capsule, not only be easy to swallow, take the very convenient absorption that also is easy to, the content of soft capsule is stablized and is difficult for contaminated, through changing dosage form, on technology, further improve its technology content, and improve its quality control standard simultaneously, former employing spectrophotography is detected the content of its Lu Ding, change high effective liquid chromatography for measuring more accurately into, it is qualitative to adopt thin layer chromatography to give simultaneously, then more helps the control of quality.If this medicine is changed over other dosage form, can provide the range of choice more widely for doctor and patient, such as granular preparation, just be more prone to accept than capsule for infant.

Concrete embodiment:

Embodiments of the invention 1: get Radix Lamiophlomidis Rotatae 1000g, pulverize and be coarse powder, add 10 times of water gagings and decoct 3 times, each 1 hour, collecting decoction filtered, and it is 1.25-1.30 (60 ℃ of-80 ℃ of surveys) that filtrate is concentrated into relative density.Dry below 80 ℃.With dried cream powder broken be fine powder (cross 100 mesh sieves), adds 1 times and measures soybean oil, 0.02 times of Cera Flava, mixing is pressed into 1000 soft capsules promptly.Specification: 0.4g/ grain.Usage and dosage: oral, one time 3, three times on the one, 7 days is a course of treatment, or in case of necessity clothes.

Embodiments of the invention 2: get Radix Lamiophlomidis Rotatae extractum 200g and add soybean oil 200g and Cera Flava 4g, again with rubber: gelatin water: the ratio of glycerol=10: 10: 4 is prepared into the soft capsule housing, is pressed into soft capsule preparation then.

Embodiments of the invention 3: get Radix Lamiophlomidis Rotatae, pulverize and be to become extractum, drying with ethanol extraction by coarse powder, dried cream powder is brokenly added an amount of sweeting agent again for fine powder, is prepared into granular preparation.

This soft capsule finds that in the clinical observation test that 100 patients are carried out the effective percentage of treatment edge of a knife pain reaches more than 97%, and is apparent in view for the bleeding effect; Because the effect of some other existing product; The granule of this production is obvious for the therapeutic effect of dysmenorrhes symptom in addition, have more than 90% the women of 1 this symptom take after about 1 hour symptom just obtain alleviating.

Claims

1, a kind of Duyiwei soft capsule is characterized in that: it is the made soft capsule preparation of dry root and rhizome extract with Labiatae Radix Lamiophlomidis Rotatae platymiscium Radix Lamiophlomidis Rotatae.

2, according to the described Duyiwei soft capsule of claim 1, it is characterized in that: described soft capsule preparation can also be: oral liquid, drop pill, granular preparation.

3, according to the preparation method of the described Duyiwei soft capsule of claim 1, it is characterized in that: get Radix Lamiophlomidis Rotatae, pulverize and be coarse powder, decoct with water, obtain extractum, drying is with the broken preparation that becomes to need for the fine powder refabrication of dried cream powder.

4, according to the preparation method of the described Duyiwei soft capsule of claim 1, it is characterized in that: get Radix Lamiophlomidis Rotatae 1000g, pulverize and be coarse powder, add 10 times of water gagings and decoct 3 times, each 1 hour, collecting decoction, filter, filtrate is concentrated into and surveys relative densities at 60 ℃-80 ℃ is 1.25-1.30, dry below 80 ℃, with dried cream powder broken be fine powder, add 1 times of amount soybean oil, 0.02 Cera Flava doubly, mixing is pressed into 1000 soft capsules promptly.