CN1557288A - Lactic acid , glycerin formulation for female vagina acidity, humidity improvement - Google Patents
Lactic acid , glycerin formulation for female vagina acidity, humidity improvement Download PDFInfo
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- CN1557288A CN1557288A CNA2004100395680A CN200410039568A CN1557288A CN 1557288 A CN1557288 A CN 1557288A CN A2004100395680 A CNA2004100395680 A CN A2004100395680A CN 200410039568 A CN200410039568 A CN 200410039568A CN 1557288 A CN1557288 A CN 1557288A
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- lactic acid
- vagina
- acid
- moist
- woman
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Abstract
The present invention is lactic acid and glycerin preparation for improving the acidity and wetness of woman's vagina, and relates to the field of medicine and health care. The new preparation consists of mainly lactic acid and glycerin, which are components of woman's vagina liquid. Lactic acid it used to regulate the acidity in vagina for benefiting the survival of lactobacillus in vagina and inhibiting invading harmful bacteria. Glycerin is used to regulate the wetness in vagina for benefiting hygiene in vagina. The used amount of lactic acid is greater than 4 mg/ml, and that of glycerin is 0.16-50 mg/ml, and the quantities of other components in the preparation are controlled within some normal ranges.
Description
Technical field
This patent provides a kind of new woman vagina acid, moist novel formulation improved.This novel formulation is mainly finished by lactic acid, glycerol.
Use composition part identical with the normal women vaginal secretion, lactic acid and glycerol are regulated the acid that improves woman vagina, moist, and this can keep composition part constant of original vaginal secretion in the woman vagina, the health of the vaginal environment that helps shielding women.
It is because this acid number is the normal acid number scope of woman vagina that application lactic acid makes the PH of this patent preparation be adjusted to 3.5-4.5.The acidity of keeping woman vagina is at PH3.5-4.5, and the existence of the useful lactobacillus that helps having in the vagina is unfavorable for invading the survival of the harmful bacteria in the vagina.It is very important and significant to the health of protecting vaginal environment that the acidity of woman vagina maintains PH3.5-4.5.
Glycerol is a kind of component that has wetting action in the woman vagina liquid.If lack enough glycerol concentrations in the vaginal secretion, it is dry to influence woman vagina.Keeping glycerol that enough concentration is arranged in vaginal secretion, is crucial to the wettability of protecting vagina.The health of this vaginal environment that helps shielding women.
Some other component of using in this patent preparation is all the material that has in the woman vagina liquid.These component consumptions of using in this patent preparation are also all in woman vagina liquid measured value scope.This is important and significant to usefulness person's application to the health of protecting vaginal environment.
Lactic acid, the amounts of glycerol used in this patent preparation are respectively:
Lactic acid:＞4 mg/ml;
Glycerol: 0.16-50 mg/ml;
Background technology:
Vagina is a key component among the women genitals.Vaginal secretion in the woman vagina can be from the transudate that includes vagina; Barthlins ' s and Skenes ' s body of gland; The epithelial cell that peels off; Residual urine and anogenital official such as cervix uteri mucus, endometrium and fallopian tube liquid etc.The vagina liquid measure of every day is about 6 gram/skies, and the vagina liquid measure will increase to some extent when sexual stimulus.Under normal circumstances, the normal acidic value of woman vagina is to maintain the PH3.5-4.5 scope.
If abnormal symptom has appearred in woman vagina such as abnormal change has taken place the acid vagina value, pH value rises or inflammation occurs.Or vaginal secretion reduces institute and causes dry not moistening these abnormal symptoms that waits of vagina, and this not only can influence the health of woman vagina environment, also can influence women's healthy and normal sexual life.Serious still can causing is attacked by a disease, and also may make the women in fertility age therefore lose fertility.Vagina has good vaginal environment health so shield women, and is a very important thing to the healthy of women.
Cause woman vagina generation acid, moist unusual reason to have multiple.Mainly have following two kinds:
1. some women fail to cause enough attention to the vaginal environment hygienic protection of oneself.Do not note protecting the health of the vaginal environment of self at ordinary times.
Some women especially menopause old women because the decline of self excretory endogenous estrogen level, thereby cause taking place vaginal environment acid, moist change, the rising of acidic value (PH5-6), the minimizing of vagina liquid measure, bad existing picture such as vagina is not moistening and dry.
The generation of above-mentioned reason can be unfavorable for the survival of lactobacillus in vagina, but helps deleterious thalline and invades vagina, grows in vagina, further can cause the women to produce some colpitis.Therefore having kept vagina has normal acid, moist, and this is a crucial major issue to the healthy of women.
Some researcheres were once measured composition part of vaginal secretion according to the project needs of being studied, and discovered and contained following material in the vaginal secretion:
Potassium, sodium, chlorine, calcium, protein, lactic acid, acetic acid, glycerol, urine, glycogen, glucose.
Some researcheres were once made the prescription of some simulation vaginal secretions according to the project needs of being studied, and were the project service of its research.
Assay determination that this patent is formed part vaginal secretion with reference to these forefathers and the mimic vaginal secretion of being formulated, the purpose design construction of studying at this patent improve woman vagina acid, moist lactic acid, glycerin preparation.
Summary of the invention
The acid abnormal change that this patent application lactic acid improves the woman vagina generation is because lactic acid is a kind of acidic materials that the intravital glucose of people produces through metabolism.Lactic acid is a kind of main acidic materials in the woman vagina liquid.Lactic acid protects useful lactobacillus in the normal survival of vagina the effect of wanting that takes care of to be arranged to keeping the normal acid vagina of women (PH3.5-4.5).If the acidic value of woman vagina liquid changes, the acid rising will be unfavorable for the survival of lactobacillus in vagina, invades vagina and grows in vagina and help deleterious thalline on the contrary, thereby can cause taking place some women's disease, influence women's health.Therefore it is crucial that the vagina that shields women has normal acidity, and lactic acid woman vagina is normal to play the considerable effect of work aspect acid keeping.
This patent improves tart another reason of woman vagina with lactic acid, it is unusual that the acidic materials that need not be different from woman vagina liquid are adjusted acid vagina, and this can prevent the original normal vaginal environment that vagina might influence the women that enters of these acidic materials.This health to the vaginal environment that shields women plays an important role and meaning.
This patent is regulated woman vagina wettability deficiency with glycerol and improved is because glycerol is not only the normal a kind of material of preserving moisture used of people, has the good moisture preserving performance.Importantly glycerol also is a kind of greasing substance that exists in the woman vagina juice.If the concentration of glycerol in vaginal secretion reduces, will influence the nonwetting and dry of woman vagina environment, life also will impact to normality.
It is to improve the lubricity of vaginal environment with the different greasing substance of woman vagina liquid phase that this patent improves another moist reason of woman vagina environment with glycerol adjustment, may more help the protection of vaginal environment health.This is meaningful and value to the healthy of women.
This patent application lactic acid improves woman vagina acidity and returns to normal acid number scope; using glycerol improves the moist deficiency of woman vagina and makes that the women is moist to return to normal degree of wetting; this is to improving women's vaginal environment, and the health of protection vaginal environment and women healthy has considerable function and significance.
This patent improves woman vagina acid, moist lactic acid, glycerin preparation has the following advantage:
1. the safety of Ying Yonging is satisfied
Lactic acid, the glycerol that this patent is used is the component in the woman vagina liquid.Use lactic acid and regulate acidity at PH3.5-4.5.This acid number is the normal acid number scope of woman vagina.This acid number can be protected the survival growth of intravaginal useful bacillus, suppresses other harmful bacterias and invades the growth of the survival in vagina in the vagina.This is safe to the application with the person.
2. application quantity is little
Lactic acid production is greater than 4 mg/ml in this patent preparation; Amounts of glycerol is the 0.16-50 mg/ml; If during 1 milliliter of each consumption: the lactic acid consumption is that 4 mg/ml glycerol consumptions are the 0.16-50 mg/ml.
3. other components in this patent preparation are all the component of woman vagina liquid, and this environmental health to the vagina that shields women is not had by the infiltration with the different material of vaginal secretion and takes care of the meaning of wanting.
The specific embodiment
For example:
Example 1: regulate and improve vagina acidity and lubricated vagina liquor #1
Prepare 1000 milliliters of liquors:
Sodium chloride (sodium ion 1.497 grams per liters) 3.78 grams
Potassium chloride (potassium ion 0.858 grams per liter) 1.63 grams
Gram of pure dawn of Sanguis Bovis seu Bubali white (0.0205 grams per liter) 0.0205
Lactic acid (4.0 grams per liter) 4.0 grams
Glycerol (0.39 grams per liter) 0.16-50 grams per liter
Carbamide (0.39 grams per liter) 0.39 gram
Glucose (5.2 grams per liter) 5.3 grams
Under agitation above each raw material is joined in proper order and contains in the 800 ml distilled water beakers, be transparence solution at last after, add lactic acid and adjust the solution acidic pH value in the 3.5-4.2 scope, add distilled water then up to 1000 milliliters.
The above-mentioned concentration of respectively forming is respectively during 1 milliliter of each consumption:
1 milliliter
3.78 milligrams in sodium chloride
1.63 milligrams in potassium chloride
White 0.0205 milligram of pure dawn of Sanguis Bovis seu Bubali
Lactic acid＞4 milligram
Glycerol 0.16-50 milligram
0.4 milligram in carbamide
5 milligrams of glucoses
Claims (6)
1. one kind is improved woman vagina acid, moist lactic acid, glycerin preparation, it is characterized in that, is made up of lactic acid, glycerol and some other component that is same as vaginal secretion.
2. woman vagina acid, moist lactic acid, the glycerin preparation of improving according to claim 1 is characterized in that the consumption of lactic acid is＞4 mg/ml, and the glycerol consumption is the 0.16-50 mg/ml.
3. woman vagina acid, moist lactic acid, the glycerin preparation of improving according to claim 1 is characterized in that acidity value is PH3.5-4.5.
4. woman vagina acid, moist lactic acid, the glycerin preparation of improving according to claim 1 is characterized in that, other components are that sodium chloride, potassium chloride, pure dawn of Sanguis Bovis seu Bubali are white, carbamide, glucose, water etc.
5. woman vagina acid, moist lactic acid, the glycerin preparation of improving according to claim 1 is characterized in that, forms part concentration and is respectively sodium chloride 3.78 grams per liters, potassium chloride 1.63 grams per liters, white 0.0205 grams per liter of pure dawn of Sanguis Bovis seu Bubali, carbamide 0.39 grams per liter, glucose 5.3 grams per liters.
6. woman vagina acid, moist lactic acid, the glycerin preparation of improving according to claim 1 is characterized in that, also can be made into other various application preparations, as various dosage forms such as ointment, suppository, membrane.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2004100395680A CN100389763C (en) | 2004-02-10 | 2004-02-10 | Lactic acid , glycerin formulation for female vagina acidity, humidity improvement |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2004100395680A CN100389763C (en) | 2004-02-10 | 2004-02-10 | Lactic acid , glycerin formulation for female vagina acidity, humidity improvement |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1557288A true CN1557288A (en) | 2004-12-29 |
| CN100389763C CN100389763C (en) | 2008-05-28 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB2004100395680A Expired - Fee Related CN100389763C (en) | 2004-02-10 | 2004-02-10 | Lactic acid , glycerin formulation for female vagina acidity, humidity improvement |
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| CN (1) | CN100389763C (en) |
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1980241A2 (en) | 2007-04-04 | 2008-10-15 | Mibelle AG | Wet wipes with vitex agnus castus extract for feminine personal care |
| CN102573858A (en) * | 2009-10-19 | 2012-07-11 | 崔元硕 | A skin external composition comprising a salt and sugar as active ingredients for preventing and treating vaginosis and the use thereof |
| CN104884070A (en) * | 2013-10-01 | 2015-09-02 | 崔元硕 | A use of the mixture of a salt and sugar in the manufacture of a medicament employed for treating lax vegina syndrome or colpoxerosis disease in a mammal |
| CN105999224A (en) * | 2016-05-11 | 2016-10-12 | 广东科玮生物技术股份有限公司 | Bionic gynecological lotion and preparing method thereof |
| CN109288793A (en) * | 2018-07-27 | 2019-02-01 | 江苏中天药业有限公司 | A kind of spray and preparation method thereof adjusted for vagina pH environment |
| CN111135157A (en) * | 2018-07-19 | 2020-05-12 | 大江生医股份有限公司 | Use of a combination of 3-phenyllactic acid and prebiotics for improving the bacterial phase |
| CN112933109A (en) * | 2021-02-03 | 2021-06-11 | 湖南奥朗特医疗器械有限公司 | Vagina pH regulator and preparation method and application thereof |
| US20230129935A1 (en) * | 2021-10-22 | 2023-04-27 | Vaginal Biome Science, Inc. | System, product and method for maintaining the vaginal microbiome |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN86107287A (en) * | 1986-10-25 | 1987-05-20 | 石道元 | Nutrition sanitizer for women |
| CN1039087C (en) * | 1993-12-29 | 1998-07-15 | 昆明宏达实业有限总公司 | External-use medicine for gynecopathy |
-
2004
- 2004-02-10 CN CNB2004100395680A patent/CN100389763C/en not_active Expired - Fee Related
Cited By (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1980241A2 (en) | 2007-04-04 | 2008-10-15 | Mibelle AG | Wet wipes with vitex agnus castus extract for feminine personal care |
| CN102573858A (en) * | 2009-10-19 | 2012-07-11 | 崔元硕 | A skin external composition comprising a salt and sugar as active ingredients for preventing and treating vaginosis and the use thereof |
| CN102573858B (en) * | 2009-10-19 | 2013-09-18 | 崔元硕 | A skin external composition comprising a salt and sugar as active ingredients for preventing and treating vaginosis and the use thereof |
| CN104884070A (en) * | 2013-10-01 | 2015-09-02 | 崔元硕 | A use of the mixture of a salt and sugar in the manufacture of a medicament employed for treating lax vegina syndrome or colpoxerosis disease in a mammal |
| CN105999224A (en) * | 2016-05-11 | 2016-10-12 | 广东科玮生物技术股份有限公司 | Bionic gynecological lotion and preparing method thereof |
| CN105999224B (en) * | 2016-05-11 | 2017-06-16 | 广东科玮生物技术股份有限公司 | A kind of biomimetic type gynaecologic washing lotion and preparation method thereof |
| CN111135157A (en) * | 2018-07-19 | 2020-05-12 | 大江生医股份有限公司 | Use of a combination of 3-phenyllactic acid and prebiotics for improving the bacterial phase |
| CN111135157B (en) * | 2018-07-19 | 2023-07-07 | 大江生医股份有限公司 | Use of a fermentation broth of Lactobacillus plantarum TCI378 containing 3-phenyllactic acid and a combination of probiotics for improving the bacterial phase |
| CN109288793A (en) * | 2018-07-27 | 2019-02-01 | 江苏中天药业有限公司 | A kind of spray and preparation method thereof adjusted for vagina pH environment |
| CN112933109A (en) * | 2021-02-03 | 2021-06-11 | 湖南奥朗特医疗器械有限公司 | Vagina pH regulator and preparation method and application thereof |
| US20230129935A1 (en) * | 2021-10-22 | 2023-04-27 | Vaginal Biome Science, Inc. | System, product and method for maintaining the vaginal microbiome |
| US20230129072A1 (en) * | 2021-10-22 | 2023-04-27 | Vaginal Biome Science, Inc. | System, product and method for maintaining the vaginal microbiome |
Also Published As
| Publication number | Publication date |
|---|---|
| CN100389763C (en) | 2008-05-28 |
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Granted publication date: 20080528 Termination date: 20100210 |