CN1850100A - Medicinal composition for treating vagina disease - Google Patents
Medicinal composition for treating vagina disease Download PDFInfo
- Publication number
- CN1850100A CN1850100A CN 200610057867 CN200610057867A CN1850100A CN 1850100 A CN1850100 A CN 1850100A CN 200610057867 CN200610057867 CN 200610057867 CN 200610057867 A CN200610057867 A CN 200610057867A CN 1850100 A CN1850100 A CN 1850100A
- Authority
- CN
- China
- Prior art keywords
- pharmaceutical composition
- nifuratel
- nysfungin
- promestriene
- described pharmaceutical
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 16
- 208000013464 vaginal disease Diseases 0.000 title description 4
- 239000000829 suppository Substances 0.000 claims abstract description 18
- 239000002552 dosage form Substances 0.000 claims abstract description 5
- 239000002775 capsule Substances 0.000 claims abstract description 4
- 239000003826 tablet Substances 0.000 claims abstract description 4
- SRQKTCXJCCHINN-NYYWCZLTSA-N nifuratel Chemical compound O=C1OC(CSC)CN1\N=C\C1=CC=C([N+]([O-])=O)O1 SRQKTCXJCCHINN-NYYWCZLTSA-N 0.000 claims description 35
- 229960002136 nifuratel Drugs 0.000 claims description 35
- IUWKNLFTJBHTSD-AANPDWTMSA-N promestriene Chemical compound C1C[C@]2(C)[C@@H](OC)CC[C@H]2[C@@H]2CCC3=CC(OCCC)=CC=C3[C@H]21 IUWKNLFTJBHTSD-AANPDWTMSA-N 0.000 claims description 33
- 229960004765 promestriene Drugs 0.000 claims description 33
- 239000008194 pharmaceutical composition Substances 0.000 claims description 24
- 210000001215 vagina Anatomy 0.000 claims description 24
- 229920000858 Cyclodextrin Polymers 0.000 claims description 9
- HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical group O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 claims description 9
- -1 hydroxypropyl Chemical group 0.000 claims description 7
- 239000000463 material Substances 0.000 claims description 6
- 241001597008 Nomeidae Species 0.000 claims description 5
- 239000007788 liquid Substances 0.000 claims description 5
- 238000005406 washing Methods 0.000 claims description 3
- 125000001301 ethoxy group Chemical group [H]C([H])([H])C([H])([H])O* 0.000 claims description 2
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 2
- 229920000642 polymer Polymers 0.000 claims description 2
- 239000003814 drug Substances 0.000 abstract description 23
- 238000002360 preparation method Methods 0.000 abstract description 12
- 239000003937 drug carrier Substances 0.000 abstract description 2
- 239000006210 lotion Substances 0.000 abstract 1
- 229940049018 mycostatin Drugs 0.000 abstract 1
- VQOXZBDYSJBXMA-NQTDYLQESA-N nystatin A1 Chemical compound O[C@H]1[C@@H](N)[C@H](O)[C@@H](C)O[C@H]1O[C@H]1/C=C/C=C/C=C/C=C/CC/C=C/C=C/[C@H](C)[C@@H](O)[C@@H](C)[C@H](C)OC(=O)C[C@H](O)C[C@H](O)C[C@H](O)CC[C@@H](O)[C@H](O)C[C@](O)(C[C@H](O)[C@H]2C(O)=O)O[C@H]2C1 VQOXZBDYSJBXMA-NQTDYLQESA-N 0.000 abstract 1
- 239000002674 ointment Substances 0.000 abstract 1
- 238000012360 testing method Methods 0.000 description 25
- 230000000694 effects Effects 0.000 description 11
- 238000006243 chemical reaction Methods 0.000 description 10
- 230000002354 daily effect Effects 0.000 description 9
- 238000011084 recovery Methods 0.000 description 9
- 229940079593 drug Drugs 0.000 description 8
- 238000011160 research Methods 0.000 description 8
- 241001465754 Metazoa Species 0.000 description 7
- 150000001875 compounds Chemical class 0.000 description 7
- 230000002159 abnormal effect Effects 0.000 description 6
- 208000024891 symptom Diseases 0.000 description 6
- 208000004926 Bacterial Vaginosis Diseases 0.000 description 5
- 201000007096 Vulvovaginal Candidiasis Diseases 0.000 description 5
- 206010047799 Vulvovaginitis trichomonal Diseases 0.000 description 5
- 239000003153 chemical reaction reagent Substances 0.000 description 5
- 235000014113 dietary fatty acids Nutrition 0.000 description 5
- 229930195729 fatty acid Natural products 0.000 description 5
- 239000000194 fatty acid Substances 0.000 description 5
- 206010020565 Hyperaemia Diseases 0.000 description 4
- 239000005662 Paraffin oil Substances 0.000 description 4
- WHGYBXFWUBPSRW-FOUAGVGXSA-N beta-cyclodextrin Chemical compound OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)CO)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1CO WHGYBXFWUBPSRW-FOUAGVGXSA-N 0.000 description 4
- 239000003795 chemical substances by application Substances 0.000 description 4
- 238000001816 cooling Methods 0.000 description 4
- 238000000465 moulding Methods 0.000 description 4
- 238000012856 packing Methods 0.000 description 4
- 230000007170 pathology Effects 0.000 description 4
- 239000013641 positive control Substances 0.000 description 4
- 206010030113 Oedema Diseases 0.000 description 3
- 230000006872 improvement Effects 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 239000013642 negative control Substances 0.000 description 3
- 241000283973 Oryctolagus cuniculus Species 0.000 description 2
- 208000025865 Ulcer Diseases 0.000 description 2
- 206010047791 Vulvovaginal dryness Diseases 0.000 description 2
- 230000009471 action Effects 0.000 description 2
- 230000013872 defecation Effects 0.000 description 2
- 238000013461 design Methods 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 230000003628 erosive effect Effects 0.000 description 2
- 230000003203 everyday effect Effects 0.000 description 2
- 230000005284 excitation Effects 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 2
- 206010025482 malaise Diseases 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 239000007935 oral tablet Substances 0.000 description 2
- 229940096978 oral tablet Drugs 0.000 description 2
- 230000001717 pathogenic effect Effects 0.000 description 2
- 239000000546 pharmaceutical excipient Substances 0.000 description 2
- 239000002574 poison Substances 0.000 description 2
- 231100000614 poison Toxicity 0.000 description 2
- 230000028327 secretion Effects 0.000 description 2
- 239000007901 soft capsule Substances 0.000 description 2
- 239000000758 substrate Substances 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- 206010003694 Atrophy Diseases 0.000 description 1
- 241000193830 Bacillus <bacterium> Species 0.000 description 1
- 244000060011 Cocos nucifera Species 0.000 description 1
- 235000013162 Cocos nucifera Nutrition 0.000 description 1
- 208000003322 Coinfection Diseases 0.000 description 1
- 101710088194 Dehydrogenase Proteins 0.000 description 1
- 206010059866 Drug resistance Diseases 0.000 description 1
- 206010015719 Exsanguination Diseases 0.000 description 1
- 241000233866 Fungi Species 0.000 description 1
- 229920002527 Glycogen Polymers 0.000 description 1
- 206010021118 Hypotonia Diseases 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 241000186660 Lactobacillus Species 0.000 description 1
- 240000001046 Lactobacillus acidophilus Species 0.000 description 1
- 235000013956 Lactobacillus acidophilus Nutrition 0.000 description 1
- LCTONWCANYUPML-UHFFFAOYSA-M Pyruvate Chemical compound CC(=O)C([O-])=O LCTONWCANYUPML-UHFFFAOYSA-M 0.000 description 1
- 206010039793 Seborrhoeic dermatitis Diseases 0.000 description 1
- 208000031737 Tissue Adhesions Diseases 0.000 description 1
- 206010046914 Vaginal infection Diseases 0.000 description 1
- 201000008100 Vaginitis Diseases 0.000 description 1
- 208000037009 Vaginitis bacterial Diseases 0.000 description 1
- 208000027709 Vulvovaginal disease Diseases 0.000 description 1
- 230000005856 abnormality Effects 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 238000010171 animal model Methods 0.000 description 1
- 230000002547 anomalous effect Effects 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 230000037444 atrophy Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 230000037396 body weight Effects 0.000 description 1
- 238000009395 breeding Methods 0.000 description 1
- 230000001488 breeding effect Effects 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 238000012790 confirmation Methods 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 230000001595 contractor effect Effects 0.000 description 1
- 238000013270 controlled release Methods 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 238000000113 differential scanning calorimetry Methods 0.000 description 1
- 230000004069 differentiation Effects 0.000 description 1
- 238000002050 diffraction method Methods 0.000 description 1
- 239000007938 effervescent tablet Substances 0.000 description 1
- 210000000981 epithelium Anatomy 0.000 description 1
- 229940011871 estrogen Drugs 0.000 description 1
- 239000000262 estrogen Substances 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 208000017561 flaccidity Diseases 0.000 description 1
- 230000004927 fusion Effects 0.000 description 1
- 229940096919 glycogen Drugs 0.000 description 1
- 238000010562 histological examination Methods 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 201000001881 impotence Diseases 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 230000007794 irritation Effects 0.000 description 1
- 230000002147 killing effect Effects 0.000 description 1
- 235000014655 lactic acid Nutrition 0.000 description 1
- 239000004310 lactic acid Substances 0.000 description 1
- 229940039696 lactobacillus Drugs 0.000 description 1
- 230000002045 lasting effect Effects 0.000 description 1
- 231100001252 long-term toxicity Toxicity 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 230000035800 maturation Effects 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- 230000008018 melting Effects 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 239000006072 paste Substances 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
- 231100000255 pathogenic effect Toxicity 0.000 description 1
- 231100000915 pathological change Toxicity 0.000 description 1
- 230000036285 pathological change Effects 0.000 description 1
- 230000001575 pathological effect Effects 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 230000008929 regeneration Effects 0.000 description 1
- 238000011069 regeneration method Methods 0.000 description 1
- 230000008439 repair process Effects 0.000 description 1
- 210000004994 reproductive system Anatomy 0.000 description 1
- 230000029058 respiratory gaseous exchange Effects 0.000 description 1
- 208000008742 seborrheic dermatitis Diseases 0.000 description 1
- 238000007619 statistical method Methods 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- ODLHGICHYURWBS-LKONHMLTSA-N trappsol cyclo Chemical compound CC(O)COC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)COCC(O)C)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1COCC(C)O ODLHGICHYURWBS-LKONHMLTSA-N 0.000 description 1
- 230000004102 tricarboxylic acid cycle Effects 0.000 description 1
- 231100000397 ulcer Toxicity 0.000 description 1
- 230000036269 ulceration Effects 0.000 description 1
- 238000002211 ultraviolet spectrum Methods 0.000 description 1
Landscapes
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
The example number | Recovery from illness | Effectively | Invalid | Total effective rate | |||||
The example number | Cure rate | The example number | Effective percentage | The example number | Inefficiency | ||||
Trichomonal vaginitis | Test group | 32 | 22 | 69.7% | 10 | 31.3% | 0 | 0% | 100% |
Matched group | 32 | 13 | 40.6% | 16 | 50% | 3 | 9.4% | 90.6% |
The example number | Recovery from illness | Effectively | Invalid | Total effective rate | |||||
The example number | Cure rate | The example number | Effective percentage | The example number | Inefficiency | ||||
Bacterial vaginitis | Test group | 32 | 19 | 60.4% | 12 | 37.5% | 1 | 3.1% | 96.9% |
Matched group | 32 | 13 | 40.6% | 18 | 56.3% | 1 | 3.1% | 96.9% |
The example number | Recovery from illness | Effectively | Invalid | Total effective rate | |||||
The example number | Cure rate | The example number | Effective percentage | The example number | Inefficiency | ||||
Vulvovaginal candidiasis | Test group | 32 | 2l | 65.6% | 10 | 31.3% | 1 | 3.1 | 96.9% |
Matched group | 32 | 11 | 34.3% | 18 | 56.3% | 3 | 9.4 | 90.6% |
Group | Pudendum is scorching hot | Vaginal dryness | Feel sick | Add up to |
Test group (96) matched group (96) | 0 7 | 0 9 | 0 4 | 0 20 |
Claims (13)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CNB2006100578676A CN100394919C (en) | 2006-03-01 | 2006-03-01 | Medicinal composition for treating vagina disease |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CNB2006100578676A CN100394919C (en) | 2006-03-01 | 2006-03-01 | Medicinal composition for treating vagina disease |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1850100A true CN1850100A (en) | 2006-10-25 |
CN100394919C CN100394919C (en) | 2008-06-18 |
Family
ID=37131612
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CNB2006100578676A Expired - Fee Related CN100394919C (en) | 2006-03-01 | 2006-03-01 | Medicinal composition for treating vagina disease |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN100394919C (en) |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102579473A (en) * | 2012-01-17 | 2012-07-18 | 程雪翔 | Nifuratel-nysfungin gel and preparation method thereof |
CN102813938A (en) * | 2012-09-14 | 2012-12-12 | 扬州大学 | Llex A-cyclodextrin polymer medicine composition for preventing and curing atherosclerosis and preparation method thereof |
CN104434942A (en) * | 2014-11-19 | 2015-03-25 | 江苏悦兴药业有限公司 | Nifuratel nysfungin vaginal soft capsule and preparation process thereof |
CN112972418A (en) * | 2021-05-18 | 2021-06-18 | 北京金城泰尔制药有限公司 | Nifuratel nysfungin vaginal soft capsule and preparation method thereof |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2832311B1 (en) * | 2001-11-21 | 2004-04-16 | Besins Int Belgique | FILM-FORMING POWDER, COMPOSITIONS COMPRISING SAME, PREPARATION METHODS AND USES THEREOF |
CA2523830A1 (en) * | 2003-04-30 | 2004-11-11 | Debiopharm S.A. | Methods and compositions using gonadotropin hormone releasing hormone |
ITMI20031640A1 (en) * | 2003-08-08 | 2005-02-09 | Mipharm S P A | BASE FOR BIOADHESIVE GEL. |
CN1600315A (en) * | 2003-09-22 | 2005-03-30 | 陈云芳 | Soft capsule combination of Cloquinate/Promestriene in use for vagina |
-
2006
- 2006-03-01 CN CNB2006100578676A patent/CN100394919C/en not_active Expired - Fee Related
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102579473A (en) * | 2012-01-17 | 2012-07-18 | 程雪翔 | Nifuratel-nysfungin gel and preparation method thereof |
CN102813938A (en) * | 2012-09-14 | 2012-12-12 | 扬州大学 | Llex A-cyclodextrin polymer medicine composition for preventing and curing atherosclerosis and preparation method thereof |
CN104434942A (en) * | 2014-11-19 | 2015-03-25 | 江苏悦兴药业有限公司 | Nifuratel nysfungin vaginal soft capsule and preparation process thereof |
CN112972418A (en) * | 2021-05-18 | 2021-06-18 | 北京金城泰尔制药有限公司 | Nifuratel nysfungin vaginal soft capsule and preparation method thereof |
CN112972418B (en) * | 2021-05-18 | 2021-08-27 | 北京金城泰尔制药有限公司 | Nifuratel nysfungin vaginal soft capsule and preparation method thereof |
Also Published As
Publication number | Publication date |
---|---|
CN100394919C (en) | 2008-06-18 |
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Legal Events
Date | Code | Title | Description |
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C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
EE01 | Entry into force of recordation of patent licensing contract |
Assignee: BEIJING LANEVA PHARMACEUTICAL CO.,LTD. Assignor: Yang Jun Contract fulfillment period: 2009.9.16 to 2014.9.15 Contract record no.: 2009990001226 Denomination of invention: Medicinal composition for treating vagina disease Granted publication date: 20080618 License type: Exclusive license Record date: 20091104 |
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LIC | Patent licence contract for exploitation submitted for record |
Free format text: EXCLUSIVE LICENSE; TIME LIMIT OF IMPLEMENTING CONTACT: 2009.9.16 TO 2014.9.15; CHANGE OF CONTRACT Name of requester: BEIJING LANGYI PHARMACEUTICAL CO., LTD. Effective date: 20091104 |
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ASS | Succession or assignment of patent right |
Owner name: BEIJING LANEVA PHARMACEUTICAL CO., LTD. Free format text: FORMER OWNER: YANG JUN Effective date: 20150319 |
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C41 | Transfer of patent application or patent right or utility model | ||
COR | Change of bibliographic data |
Free format text: CORRECT: ADDRESS; FROM: 100020 CHAOYANG, BEIJING TO: 100024 CHAOYANG, BEIJING |
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TR01 | Transfer of patent right |
Effective date of registration: 20150319 Address after: 100024 No. 559 Shuangqiao Village, Guan Zhuang Town, Beijing, Chaoyang District Patentee after: BEIJING LANEVA PHARMACEUTICAL CO.,LTD. Address before: 100020, No. 903, building 1302, nine district, Chaoyang District, Beijing, Jinsong Patentee before: Yang Jun |
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CP03 | Change of name, title or address |
Address after: 101300 No.9 Mintai Road, Beiwu Town, Shunyi District, Beijing Patentee after: Beijing Jincheng Taier Pharmaceutical Co.,Ltd. Address before: 100024 No. 559, shuangqiaoli, Guanzhuang Township, Chaoyang District, Beijing Patentee before: BEIJING LANEVA PHARMACEUTICAL Co.,Ltd. |
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CP03 | Change of name, title or address | ||
CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20080618 |
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CF01 | Termination of patent right due to non-payment of annual fee |