CN1552466A - Absorbable medical chitin suture lines and their production - Google Patents
Absorbable medical chitin suture lines and their production Download PDFInfo
- Publication number
- CN1552466A CN1552466A CNA031299768A CN03129976A CN1552466A CN 1552466 A CN1552466 A CN 1552466A CN A031299768 A CNA031299768 A CN A031299768A CN 03129976 A CN03129976 A CN 03129976A CN 1552466 A CN1552466 A CN 1552466A
- Authority
- CN
- China
- Prior art keywords
- chitosan
- solution
- naoh
- stitching thread
- absorbable medical
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000004519 manufacturing process Methods 0.000 title claims description 13
- 229920002101 Chitin Polymers 0.000 title 1
- 229920001661 Chitosan Polymers 0.000 claims abstract description 53
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 20
- 235000015112 vegetable and seed oil Nutrition 0.000 claims abstract description 7
- 239000008158 vegetable oil Substances 0.000 claims abstract description 7
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 51
- 239000000243 solution Substances 0.000 claims description 25
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims description 18
- 239000012047 saturated solution Substances 0.000 claims description 13
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 12
- 238000000034 method Methods 0.000 claims description 9
- 239000005357 flat glass Substances 0.000 claims description 7
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 5
- 239000011521 glass Substances 0.000 claims description 5
- 238000003756 stirring Methods 0.000 claims description 4
- 238000005406 washing Methods 0.000 claims description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 4
- 230000001476 alcoholic effect Effects 0.000 claims description 3
- 239000012141 concentrate Substances 0.000 claims description 3
- 238000001035 drying Methods 0.000 claims description 3
- 239000007788 liquid Substances 0.000 claims description 3
- 239000002994 raw material Substances 0.000 claims description 3
- 239000002253 acid Substances 0.000 claims description 2
- 238000011010 flushing procedure Methods 0.000 claims description 2
- 239000011259 mixed solution Substances 0.000 claims description 2
- 238000002791 soaking Methods 0.000 claims description 2
- 239000011248 coating agent Substances 0.000 abstract 1
- 238000000576 coating method Methods 0.000 abstract 1
- 235000011187 glycerol Nutrition 0.000 abstract 1
- 229920006395 saturated elastomer Polymers 0.000 abstract 1
- 238000010521 absorption reaction Methods 0.000 description 4
- 210000000589 cicatrix Anatomy 0.000 description 4
- 239000000463 material Substances 0.000 description 4
- 230000006196 deacetylation Effects 0.000 description 3
- 238000003381 deacetylation reaction Methods 0.000 description 3
- 238000002360 preparation method Methods 0.000 description 3
- 230000002939 deleterious effect Effects 0.000 description 2
- 239000012153 distilled water Substances 0.000 description 2
- 238000010438 heat treatment Methods 0.000 description 2
- 229920002521 macromolecule Polymers 0.000 description 2
- 239000005445 natural material Substances 0.000 description 2
- 229920002994 synthetic fiber Polymers 0.000 description 2
- 102000016943 Muramidase Human genes 0.000 description 1
- 108010014251 Muramidase Proteins 0.000 description 1
- 108010062010 N-Acetylmuramoyl-L-alanine Amidase Proteins 0.000 description 1
- 239000002250 absorbent Substances 0.000 description 1
- 230000002745 absorbent Effects 0.000 description 1
- 210000001691 amnion Anatomy 0.000 description 1
- 229910052785 arsenic Inorganic materials 0.000 description 1
- RQNWIZPPADIBDY-UHFFFAOYSA-N arsenic atom Chemical compound [As] RQNWIZPPADIBDY-UHFFFAOYSA-N 0.000 description 1
- 230000000680 avirulence Effects 0.000 description 1
- 239000012620 biological material Substances 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 230000002950 deficient Effects 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 239000004325 lysozyme Substances 0.000 description 1
- 229960000274 lysozyme Drugs 0.000 description 1
- 235000010335 lysozyme Nutrition 0.000 description 1
- QSHDDOUJBYECFT-UHFFFAOYSA-N mercury Chemical compound [Hg] QSHDDOUJBYECFT-UHFFFAOYSA-N 0.000 description 1
- 231100000957 no side effect Toxicity 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 229920000728 polyester Polymers 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 230000002980 postoperative effect Effects 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 229920002554 vinyl polymer Polymers 0.000 description 1
- 230000029663 wound healing Effects 0.000 description 1
Abstract
An absorbable medical chitosan suture is prepared from chitosan and glycerine or vegetable oil through preparing coarse chitosan suture, preparing saturated high-concentration chitosan solution, twisting and coating film. Its advantage is high tension strength.
Description
One, technical field
The present invention relates to a kind of manufacture method of suture, especially with the pure natural macromolecule polysaccharide---chitosan is made the manufacture method of absorbable medical suture.
Two, technical background
Medical operation suture thread mainly contains two classes, and a class is non-absorbent stitching thread, and the sutural disadvantage of this class is to need to take out stitches after the operation, and online stitch place often leaves tangible cicatrix.Another kind of is the absorbability suture, and this type of stitching thread postoperative need not to take out stitches, and line stitch place cicatrix is slight or do not have a cicatrix.So many domestic and international research institutions all are being devoted to the research in this field.
At present, domestic had some patents of invention for absorbable medical suture, is called polyester absorbable medical suture and method for production thereof as patent publication No. for the CN1195559A name; The CN85108766A name is called suture of amniotic membrane and preparation method thereof; The CN1051510A name is called collagen---and polyvinyl alcoholic operation sutures and preparation method thereof and CN1125622A name are called medical absorbable biological material, the flexible suture line.These patent institute materials useds are the composite of synthetic material or natural material or synthetic material and natural material.Though these materials have certain degradable, can be organized the function that cell absorbs, but still there is certain weak point, lower as sutural fracture strength, the absorption phase is long, certain zest is arranged, biocompatibility is relatively poor, complex manufacturing, or material source has the defective of aspects such as certain limitation.
Three, summary of the invention
Purpose of the present invention is that raw material is made the absorbability suture with the chitosan exactly, overcomes the existing shortcoming of above-mentioned absorbability stitching thread, and another object of the present invention is the manufacture method that provides the chitosan absorbable medical suture.
Chitosan is a kind of pure natural macromolecule polysaccharide, its avirulence, nonirritant, without any side effects, and can well have been studies confirm that by the many scientific research institutions in the world by the characteristic of the lysozyme degraded and absorbed of inside of human body and raw material sources extensive, chitosan is the material that the absorbability suture is made in a kind of splendid being used to thus.
Technological process of the present invention is simple, and is easy to operate, is easy to suitability for industrialized production, and do not use any deleterious reagent and deleterious organic solvent in whole process of production, thereby makes security of products more reliable.
The purpose of invention solves by following scheme:
Chitosan absorbable medical suture main component is a chitosan, also is added with an amount of glycerol or vegetable oil in addition to improve sutural pliability.
The manufacture method of chitosan absorbable medical suture:
1, makes chitosan stitching thread thick line
Choose fine chitosan,, be configured to certain density chitosan solution with acetic acid or dissolve with hydrochloric acid solution.Can add a certain amount of softener in the solution, softener can be glycerol or some vegetable oil.Solution is fully stirred the back under vacuum condition, remove bubble, solution is poured in the plate glass groove, then the glass guide channel horizontal positioned.Dry at a certain temperature, make it film forming, film is cut into strip on special mould, then groove being put into certain density NaOH solution or NaOH and alcoholic acid mixed solution heats, (between 40 ℃-98 ℃ of the temperature), after 5-30 minute, the strip film is rolled to the centre by both sides nature, be the bar wire and from glass planar, come off automatically, be chitosan stitching thread thick line.Thick line taken out in pure water clean repeatedly for several times, NaOH or NaOH and alcohol flushing is clean, dry standby.
2, make the chitosan saturated solution of high concentration
Prepare certain density acetic acid or hydrochloric acid solution, add excessive chitosan, fully stir, be made into the saturated solution of chitosan, solution is filtered, get clear liquid, and then concentrate, obtain the chitosan saturated solution of high concentration.
3, twisted filament
Above-mentioned prepared chitosan stitching thread thick line is put into taken out after soaking certain hour in the saturated solution of chitosan, on twisting frame, twist with the fingers into filament, and filament is suitably stretched, after to be dried, take off, put into NaOH (2%) solution and soak taking-up in 5-30 minute, washing totally is the finished product stitching thread.
4, plated film
As requested, stitching thread is put into again soaked certain hour in the saturated solution of chitosan and take out, after the drying, put into NaOH (2%) solution and soak taking-ups in 5-30 minute once more, washing totally.This operation can repeat repeatedly, to reach repeatedly " plated film ", improves the smoothness on stitching thread surface and the diameter of increase line, and improves the purpose of the tensile strength of line.
Advantage of the present invention is:
1, no matter the stitching thread that makes of the present invention is under dry state or hygrometric state condition, the tensile strength of this line and corresponding knot strength, its works very well.
2, the stitching thread that makes of the present invention, its absorption phase is 7-15 days, it can satisfy clinical instructions for use its suitable absorption.Deposit under suitable condition, the degradation rate of this line is very little, and every index of this line all is not less than the regulation of American Pharmacopeia the 22 edition.
3, add the pliability that an amount of glycerol or vegetable oil have improved this line in the stitching thread of the present invention, more convenient when using clinically.
4, the obtained stitching thread of the present invention proves through zoopery and clinic trial, this line do not have any tissue reaction, non-stimulated, have no side effect, absorb fully, and the mending stitch place does not have cicatrix behind the wound healing.
Four, specific embodiment:
(1) selects suitable chitosan, the deacetylation of chitosan, viscosity, molecular weight, pH value, the ash index of grading is: deacetylation: 65%-95%, and moisture :≤10%, ash :≤1%, viscosity: 80mPa.s-200mPa.s, total arsenic :≤1.0mg/kg is (with AS
2O
2Meter), lead :≤1.5mg/kg (in pb), hydrargyrum :≤0.3mg/Kg (in Hg); The selection of chitosan should absorb the length of phase according to stitching thread to be determined, general deacetylation height, and its absorption phase is then long more, and the viscosity of chitosan or molecular weight are high more, and then the tensile strength of line is big more.With acetic acid or the dissolving with hydrochloric acid of 0.1%-2%, the concentration that makes chitosan can add a small amount of glycerol or vegetable oil to improve the pliability of stitching thread finished product then as required at 0.01%-2%.Stir the vacuum removal bubble.
(2) saturated solution of preparation chitosan, acetic acid or dissolving with hydrochloric acid chitosan with 0.05%-0.5% make chitosan excessive,, filter more than 6 hours in 40 ℃-60 ℃ stirrings, get clear liquid.Heating concentrates under vacuum condition then, and (temperature is at 40 ℃-60 ℃) make chitosan concentration between 2%-15%.
(3) system thick line: pour in the plate glass groove with 1 chitosan solution that makes, the amount of pouring into should decide according to sutural thickness model.Then the plate glass groove is heated oven dry under level conditions, temperature is advisable between 30 ℃-60 ℃.After the oven dry, chitosan is film forming on the plate glass groove, with the film tool plate glass groove is entangled, and then film is cut into strip, and the width of bar is generally 0.5-3cm.The plate glass groove is being put into solution by NaOH (0.5%-2%) or NaOH (0.5%-2%) and ethanol (0.1%-1%) in 40 ℃ of-98 ℃ of heating then, be curled into wire and come off until the strip chitosan film from glass plate, line is taken out, clean up with distilled water, be thick line after drying.
(4) 3 thick lines that make are put into the 2 chitosan saturated solutions that make and soaked after 2-20 minute, take out, twisted filament and stretching on twisting frame.Dry the back and in 2%NaOH solution, soaked 20 minutes, take out, be finished product after in distilled water, cleaning up.Also can as required this line be put into the chitosan saturated solution that has made and soak, taking-up is dried, put into 2%NaOH solution again and soak once more, so repeated multiple times can make line repeatedly " plated film " to improve its smoothness and tensile strength.
Claims (3)
1, a kind of chitosan absorbable medical suture, primary raw material is a chitosan, it is characterized in that: it also comprises glycerol or vegetable oil.
2, a kind of manufacture method of chitosan absorbable medical suture is characterized in that: its manufacturing process flow is:
(1) makes chitosan stitching thread thick line
Choose fine chitosan,, be configured to certain density chitosan solution with acetic acid or dissolve with hydrochloric acid solution.Can add a certain amount of softener in the solution, softener can be glycerol or some vegetable oil.Solution is fully stirred the back under vacuum condition, remove bubble, solution is poured in the plate glass groove, then the glass guide channel horizontal positioned.Dry at a certain temperature, make it film forming, film is cut into strip on special mould, then groove is put into NaOH solution or NaOH and alcoholic acid mixed solution heats, temperature is between 40 ℃-98 ℃, and after 5-30 minute, the strip film is rolled to the centre by both sides nature, be the bar wire and from glass planar, come off automatically, be chitosan stitching thread thick line.Thick line taken out in pure water clean repeatedly for several times, NaOH or NaOH and alcohol flushing is clean, dry standby.
(2) the chitosan saturated solution of making high concentration
Prepare certain density acetic acid or hydrochloric acid solution, add excessive chitosan, fully stir, be made into the saturated solution of chitosan, solution is filtered, get clear liquid, and then concentrate, obtain the chitosan saturated solution of high concentration.
(3) twisted filament
Above-mentioned prepared chitosan stitching thread thick line is put into taken out after soaking certain hour in the saturated solution of chitosan, on twisting frame, twist with the fingers into filament, and filament is suitably stretched, after to be dried, take off, put into 2% NaOH solution and soak and took out in 5-30 minute, washing totally is the finished product stitching thread.
(4) plated film
Stitching thread is put into again soaked certain hour in the saturated solution of chitosan and take out, after the drying, put into NaOH (2%) solution and soak taking-ups in 5-30 minute once more, washing totally.This operation can repeat repeatedly.
3, the manufacture method of chitosan absorbable medical suture according to claim 2 is characterized in that: the described NaOH solution concentration of step (1) is 0.1%-2%, and concentration of alcohol is 1%-5%.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB031299768A CN100420488C (en) | 2003-06-03 | 2003-06-03 | Absorbable medical chitin suture lines and their production |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB031299768A CN100420488C (en) | 2003-06-03 | 2003-06-03 | Absorbable medical chitin suture lines and their production |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1552466A true CN1552466A (en) | 2004-12-08 |
| CN100420488C CN100420488C (en) | 2008-09-24 |
Family
ID=34322610
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB031299768A Expired - Lifetime CN100420488C (en) | 2003-06-03 | 2003-06-03 | Absorbable medical chitin suture lines and their production |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN100420488C (en) |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102406961A (en) * | 2011-11-29 | 2012-04-11 | 司忠 | Absorbable operating suture line and preparation method thereof |
| CN101703794B (en) * | 2009-11-18 | 2013-06-12 | 中国人民解放军第二炮兵总医院 | Controlled degradable surgical suture thread and fabricating method thereof |
| CN103301510A (en) * | 2013-06-20 | 2013-09-18 | 孙文善 | Acupuncture implantation material |
| CN107811752A (en) * | 2017-09-21 | 2018-03-20 | 温州医科大学 | A kind of biocompatibility Aqueous Humor of Glaucomas drainage tube and preparation method thereof |
| CN108348660A (en) * | 2015-09-03 | 2018-07-31 | 株式会社真友生物 | It is coated with the manufacturing method and its high performance sewing yarn of the high performance sewing yarn of hyaluronate |
| CN115300662A (en) * | 2022-01-28 | 2022-11-08 | 温州医科大学 | Chitosan surgical suture and preparation method thereof |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN85108766B (en) * | 1985-11-22 | 1988-02-17 | 吕强 | Suture of amniotic membrane and its mfg process |
| CN1034351C (en) * | 1994-10-12 | 1997-03-26 | 中国纺织大学 | Method for preparing chitin fiber |
| CN1065773C (en) * | 1994-12-28 | 2001-05-16 | 天津纺织工学院膜天膜技术工程公司 | Flexible suture of absobable biological material for medical use |
| JP3104212B2 (en) * | 1995-11-24 | 2000-10-30 | 大日精化工業株式会社 | Method for treating chitin and / or chitosan particles |
| CN1062773C (en) * | 1998-04-16 | 2001-03-07 | 中国纺织大学 | Polyester absorbable medical suture and its manufacturing method |
| CN1301758C (en) * | 2002-11-14 | 2007-02-28 | 王浦林 | Medical supplementary material producing process |
-
2003
- 2003-06-03 CN CNB031299768A patent/CN100420488C/en not_active Expired - Lifetime
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101703794B (en) * | 2009-11-18 | 2013-06-12 | 中国人民解放军第二炮兵总医院 | Controlled degradable surgical suture thread and fabricating method thereof |
| CN102406961A (en) * | 2011-11-29 | 2012-04-11 | 司忠 | Absorbable operating suture line and preparation method thereof |
| CN102406961B (en) * | 2011-11-29 | 2013-12-18 | 司忠 | Absorbable operating suture line and preparation method thereof |
| CN103301510A (en) * | 2013-06-20 | 2013-09-18 | 孙文善 | Acupuncture implantation material |
| CN103301510B (en) * | 2013-06-20 | 2014-12-24 | 孙文善 | Acupuncture implantation material |
| CN108348660A (en) * | 2015-09-03 | 2018-07-31 | 株式会社真友生物 | It is coated with the manufacturing method and its high performance sewing yarn of the high performance sewing yarn of hyaluronate |
| CN108348660B (en) * | 2015-09-03 | 2021-04-06 | 株式会社真友生物 | Method for manufacturing high-performance suture coated with hyaluronate and high-performance suture thereof |
| CN107811752A (en) * | 2017-09-21 | 2018-03-20 | 温州医科大学 | A kind of biocompatibility Aqueous Humor of Glaucomas drainage tube and preparation method thereof |
| CN115300662A (en) * | 2022-01-28 | 2022-11-08 | 温州医科大学 | Chitosan surgical suture and preparation method thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN100420488C (en) | 2008-09-24 |
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