CN1549409A

CN1549409A - Quasi-phase matching photodynamic therapeutic and diagnostic laser light source

Info

Publication number: CN1549409A
Application number: CNA031238505A
Authority: CN
Inventors: 黄衍介; 林彦颖; 陈进庭
Original assignee: Applied Biology Photoelectric Science & Technology Co Ltd
Current assignee: Applied Biology Photoelectric Science & Technology Co Ltd
Priority date: 2003-05-13
Filing date: 2003-05-13
Publication date: 2004-11-24

Abstract

The present invention relates to a laser system equipment, in particular, it is a laser light source for medical photodynamic therapy and diagnosis. Said laser system equipment includes a laser pump source which can emit at least a specific laser light wavelength for wavelength converter in the pump-laser resonant cavity system; a wavelength converter which uses a quasi-phase-matched technique to convert said specific laser light wavelength into at least one laser light wavelength applicable to photodynamic therapy and diagnosis; a laser resonant cavity system, said wavelength converter is placed in its cavity interior and used for increasing laser light intensity output; and an optical transmission output device for receiving and transmitting laser light outputted by said laser resonant cavity system.

Description

Accurate phase matched optical dynamic therapy and diagnosis LASER Light Source

(1) technical field

The relevant a kind of laser system device of the present invention refers to a kind of medical science optical dynamic therapy (Photodynamic Therapy that is applicable to especially; PDT) and the diagnosis (photodynamic diagnosis; PDD) LASER Light Source of usefulness.

(2) background technology

Malignant tumour has jumped to first of the dead main cause of compatriots.The accurate diagnosis of initial stage malignant tumour and treatment in time are the prerequisites behind good the healing.Aspect diagnosis of malignant tumor, provide suitable reliable diagnostic result as the fluorescence diagnosis method of sensitising agent to add fluorescent dye.This method is known light power diagnosis (photodynamicdiagnosis; PDD) method.The general sensitising agent that uses, for example hematoporphyrin derivative (hematoporphyrinderivative; HpDs) and forerunner's medicine 5-aminolevulinic acid (5-aminolevulinic acid of heme biosynthesis (hem-biosynthesis); ALA) etc. because of very responsive, make them be woven with higher accumulation and park the time for tumor group to tissue blood vessel and metabolic hyperplasia activity.Because these photaesthesia agent can scatter detectable fluorescent behind the energy that absorbs special wavelength light, therefore can be used as the diagnostic tool of pathological tissues.Because it is stronger to add the fluorescent that light sense substance produces, therefore, can further develop the imaging technique of radiography.Sensitising agents such as hematoporphyrin derivative and 5-aminolevulinic acid cooperate special optical detection system to be proved the early-stage cancer that can effectively be detected on organs such as lung, larynx, esophagus or bladder.For example, be longer than 405-415 how during rice blue-light excited when these sensitising agents by ripple, they will launch the ruddiness that is detected easily.

Known optical dynamic therapy (photodynamic therapy; PDT) method is a kind of novelty and reliable treatment of cancer method.This method is sufferer to be imposed exogenous photosensitizing chemical thing (with the employed sensitising agent of light power diagnosis method) make its tumor tissues produce sensitivity to the nonthermal source light source, and then reaches the purpose of destroying tumor tissues.These photosensitive drugs are chemical inertness normally, optionally only tumor tissues is had the parent also only absorbs some specific wavelength according to property light source.Can believe that the tissue injury that optical dynamic therapy causes is to cause via the singlet oxygen cytotoxin that the second class photochemical reaction is produced.In view of this, the optical dynamic therapy method is a kind of non-invasive therapy and the anxiety of spreading all over property of nothing or cumulative toxicity.Therefore, the optical dynamic therapy method is that tumor-localizing, sensitising agent by sensitising agent determined in the absorbing light dosage of in-house concentration and distribution situation, oxygen content and sensitising agent on the curative effect of treatment cancer.In in the past 10 years, the achievement of the development of second generation sensitising agent and photoelectricity science and technology has impelled the optical dynamic therapy method to be accepted as the pattern course of treatment gradually on the treatment cancer.So far, sensitising agent blood derivative (PhotofrinR) has been checked and approved as the optical dynamic therapy of epithelium carcinoma of urinary bladder, cancer of the esophagus, the early stage of lung cancer, cancer of the stomach and cervix cancer etc. by many countries and has been treated agent.In addition, U.S. food and FAD (FDA) been have also have been checked and approved and have been utilized the clinical treatment of optical dynamic therapy method as chronic eczema (using the LevulanR sensitising agent) and old ARM (use dimension to look and reach the VisudyneR sensitising agent).Therefore, optical dynamic therapy gives with the repetition formula sensitising agent of its uniqueness and the rayed advantage course of treatment successfully is integrated in the multi-faceted treatment body.

In the prior art, the employed radiation source of light power diagnosis and optical dynamic therapy mostly is non-people having the same aspiration and interest light source such as xenon lamp, or is the semiconductor laser of certain special wavelength.Use non-people having the same aspiration and interest light source, except the problem that thermal effect is arranged, it diagnoses or treats the required spectrum power of optical wavelength because of needing device one optical filter to decay.Generally speaking, concentrate and propagate the specific destination organization not a duck soup of a non-people having the same aspiration and interest light source to.Therefore, the semiconductor laser that has higher frequency spectrum power and a preferable boundling transmission capacity replaces general non-people having the same aspiration and interest light source gradually on light power diagnosis and optical dynamic therapy.Yet, the wavelength tunability that semiconductor laser is launched because of the restriction of material behavior by strangulation, can't carry out significantly wavelength adjustment, therefore, the wavelength of its emission just is that the sensitising agent specific absorption person of institute probability is little naturally.In addition, because of the laser emitting region of semiconductor laser is very little, heat dissipation problem benefit shape when its high power running is serious.

Comprehensive above-mentioned institute opinion, light power diagnosis and photodynamic therapy system are badly in need of the lasing light emitter of a high-quality wavelength-tunable at present, use the accuracy of lifting diagnosis and the popularity and the completeness of sensitivity and treatment.

(3) summary of the invention

Main purpose of the present invention provides a kind of laser system device, utilize quasi-phase matching to realize that the laser of wavelength Conversion and wavelength-tunable produces, as the light source of medical light power diagnosis and photodynamic therapy system, be used to promote the accuracy of diagnosis and the popularity and the completeness of sensitivity and treatment.

The invention provides a kind of laser system device, particularly be applicable to medical science optical dynamic therapy (PDT) and diagnose (PDD) to use LASER Light Source, this laser system device comprises: a laser pump source, it launches at least one specific laser light wavelength, is used for the intrasystem wavelength shifter of pump one laser resonator; One wavelength shifter, it utilizes accurate phase matched (QPM) technology, be used to change specific laser light wavelength that this laser pump source launches at least one be applicable to the laser light wavelength of optical dynamic therapy (PDT) and diagnosis (PDD) usefulness; One laser resonator system, its chamber is built-in with this wavelength shifter, is used to increase this wavelength shifter and produces the laser light intensity output that is applicable to optical dynamic therapy (PDT) and diagnosis (PDD) usefulness through this laser pump source pump; And an optical delivery follower, it is used to receive and transmit the laser light of this laser resonator system output, and by its terminal optics output device, at least one specific objective point output is shone.

According to above-mentioned conception, also comprise at least one coupling lens between this laser pump source and this laser resonator system in the laser system device, so that this laser pump source is able to enter this laser resonator system via these at least one coupling lens.

According to above-mentioned conception, these coupling lens optionally are coated with pumping optical wavelength anti-reflective film and have the specific curvature focal length, enter this laser resonator system with the pump energy that receives with this laser pump source of coupling.

According to above-mentioned conception, this optical delivery follower in the laser system device, it is made up of as laser output institute as laser transmission and at least one light pen at least one optical fiber.

According to above-mentioned conception, can optical fiber pigtail (fiber pigtail) technology coupling between this laser resonator system and this optical delivery follower in the laser system device.

According to above-mentioned conception, also comprise a lens coupling system in the laser system device between this laser resonator system and this optical delivery follower, it has at least one lens, and the laser light that is used for this laser resonator system output of effective coupling enters an optical delivery follower.

According to above-mentioned conception, can optical fiber pigtail (fiber pigtail) technology coupling between this lens coupling system and this optical delivery follower.

According to above-mentioned conception, this wavelength shifter can be made of at least one quasi-phase-matching crystals in the laser system device.

According to above-mentioned conception, this wavelength shifter can be made of an at least one quasi-phase-matching crystals and a temperature regulator in the laser system device, is used to regulate and control this quasi-phase-matching crystals in specified temp.

According to above-mentioned conception, this wavelength shifter can be made of at least one quasi-phase-matching crystals and one micron driver in the laser system device, is used to choose the non-linear wavelength conversion of this quasi-phase-matching crystals grating periodic region intercropping wherein.

According to above-mentioned conception, this wavelength shifter can be made of at least one quasi-phase-matching crystals, a temperature regulator and one micron driver in the laser system device, be used to regulate and control this quasi-phase-matching crystals in specified temp, and be used to choose the non-linear wavelength conversion of this quasi-phase-matching crystals grating periodic region intercropping wherein.

According to above-mentioned conception, the straight formula resonant cavity that this laser resonator system can be made up of a pair of laser mirror in the laser system device, it is used for resonance and produces at least one laser light wavelength and power that is applicable to optical dynamic therapy (PDT) and diagnosis (PDD) usefulness.

According to above-mentioned conception, in the laser system device this laser resonator system can by a laser mirror and be arranged at the employed quasi-phase-matching crystals of this wavelength shifter the laser output face suitable reflection or penetrate optics dielectric mirror coating and the straight formula resonant cavity formed, it is to be used for resonance to produce at least one laser light wavelength and power that is applicable to optical dynamic therapy (PDT) and diagnosis (PDD) usefulness.

According to above-mentioned conception, in the laser system device this laser resonator system be can by one be arranged at the employed quasi-phase-matching crystals of this wavelength shifter the laser pump end face suitable reflection or penetrate optics dielectric mirror coating and a laser mirror and the straight formula resonant cavity formed, it is to be used for resonance to produce at least one laser light wavelength and power that is applicable to optical dynamic therapy (PDT) and diagnosis (PDD) usefulness.

According to above-mentioned conception, this laser resonator system can or penetrate optics dielectric mirror coating and the straight formula resonant cavity formed by the suitable reflection of a pair of laser pump end face that is arranged at the employed quasi-phase-matching crystals of this wavelength shifter respectively and laser output face in the laser system device, and it is to be used for resonance to produce at least one laser light wavelength and power that is applicable to optical dynamic therapy (PDT) and diagnosis (PDD) usefulness.

According to above-mentioned conception, this laser resonator system is the ring type resonant cavity that can be made up of four laser mirrors in the laser system device, and it is to be used for unidirectional resonance to produce at least one laser light wavelength and power that is applicable to optical dynamic therapy (PDT) and diagnosis (PDD) usefulness.

According to above-mentioned conception, the framework of this laser resonator system can be phase matched optical parametric oscillation (OPO) device surely in the laser system device, is used to produce at least one laser light wavelength and power that is applicable to optical dynamic therapy (PDT) and diagnosis (PDD) usefulness.

According to above-mentioned conception, the framework of this laser resonator system can be phase matched optical parametric oscillation (OPO) device tandem one non-linear wavelength transducer surely in the laser system device, is used to produce at least one laser light wavelength and power that is applicable to optical dynamic therapy (PDT) and diagnosis (PDD) usefulness.

According to above-mentioned conception, this non-linear wavelength transducer can frequency multiplication (SHG) fabrication techniques form.

According to above-mentioned conception, this non-linear wavelength transducer can sum of fundamental frequencies (SFG) fabrication techniques form.

According to above-mentioned conception, this wavelength shifter also comprises a quasi-phase-matching crystals as accurate phase matched optical parametric oscillation (OPO) gain body in the laser system device, and at least one quasi-phase-matching crystals is as non-linear wavelength conversion gain body in addition.

According to above-mentioned conception, this wavelength shifter also comprises a quasi-phase-matching crystals as accurate phase matched optical parametric oscillation (OPO) gain body in the laser system device, and at least one nonlinear crystal is as non-linear wavelength conversion gain body in addition.

According to above-mentioned conception, the employed quasi-phase-matching crystals of this wavelength shifter can be periodic lattice polarization reversal lithium niobate (Periodically Poled Lithium Niobate, PPLN) crystal in the laser system device.

According to above-mentioned conception, this wavelength shifter can be a single quasi-phase-matching crystals in the laser system device, and it comprises a plurality of different grating cycles and is made side by side, with as optical parametric oscillation (OPO) the gain body that provides multiple accurate phase matched mode to select.

According to above-mentioned conception, this single quasi-phase-matching crystals, also include a plurality of different grating periodic region between its arbitrary row grating periodic region, with gain body as optical parametric oscillation (OPO) gain body that provides multiple accurate phase matched mode to select and multiple non-linear wavelength conversion regime selection.

According to above-mentioned conception, this wavelength shifter can be a single quasi-phase-matching crystals in the laser system device, it comprises a plurality of different grating period range tandems and is made, wherein one first grating period range is as accurate phase matched optical parametric oscillation (OPO) gain body, second or other grating period ranges as non-linear wavelength conversion gain body.

According to above-mentioned conception, this laser pump source can be 1.064 microns laser light of a neodymium-doped yttrium-aluminum garnet (Nd:YAG) laser emission wavelength in the laser system device, be used for this wavelength shifter of pump, and wherein this single quasi-phase-matching crystals is to be one-period property lattice polarization counter-rotating lithium niobate (PPLN) crystal, wherein the grating cycle of this first grating period range is to be 29.7 microns again, and the grating cycle of this second grating period range is to be 11.3 microns.

According to above-mentioned conception, this laser pump source can be 1.064 microns laser light of a Nd-doped yttrium vanadate (Nd:YVO4) laser emission wavelength in the laser system device, be used for this wavelength shifter of pump, and wherein this single quasi-phase-matching crystals is to be one-period property lattice polarization counter-rotating lithium niobate (PPLN) crystal, wherein the grating cycle of this first grating period range is to be 29.7 microns again, and the grating cycle of this second grating period range is to be 11.3 microns.

According to above-mentioned conception, this laser pump source can be 1.064 microns laser light of a neodymium-doped yttrium-aluminum garnet (Nd:YAG) laser emission wavelength in the laser system device, be used for this wavelength shifter of pump, and wherein this single quasi-phase-matching crystals is to be one-period property lattice polarization counter-rotating lithium niobate (PPLN) crystal, wherein the grating cycle of this first grating period range is to be 30.5 microns again, and the grating cycle of this second grating period range is to be 12.4 microns.

According to above-mentioned conception, this laser pump source can be 1.064 microns laser light of a Nd-doped yttrium vanadate (Nd:YVO4) laser emission wavelength in the laser system device, be used for this wavelength shifter of pump, and wherein this single quasi-phase-matching crystals is to be one-period property lattice polarization counter-rotating lithium niobate (PPLN) crystal, wherein the grating cycle of this first grating period range is to be 30.5 microns again, and the grating cycle of this second grating period range is to be 12.4 microns.

According to above-mentioned conception, this laser pump source can be 1.064 microns laser light of a neodymium-doped yttrium-aluminum garnet (Nd:YAG) laser emission wavelength in the laser system device, be used for this wavelength shifter of pump, and wherein this single quasi-phase-matching crystals is to be one-period property lattice polarization counter-rotating lithium niobate (PPLN) crystal, wherein the grating cycle of this first grating period range is at the 29.7-30.5 micrometer range again, the grating cycle of this second grating period range is to be 11.3 microns, and the grating cycle of another the 3rd grating period range is to be 12.4 microns.

According to above-mentioned conception, this laser pump source can be 1.064 microns laser light of a Nd-doped yttrium vanadate (Nd:YVO4) laser emission wavelength in the laser system device, be used for this wavelength shifter of pump, and wherein this single quasi-phase-matching crystals is to be one-period property lattice polarization counter-rotating lithium niobate (PPLN) crystal, wherein the grating cycle of this first grating period range is at the 29.7-30.5 micrometer range again, the grating cycle of this second grating period range is to be 11.3 microns, and the grating cycle of another the 3rd grating period range is to be 12.4 microns.

According to above-mentioned conception, this laser pump source can be 1.064 microns laser light of a neodymium-doped yttrium-aluminum garnet (Nd:YAG) laser emission wavelength in the laser system device, be used for this wavelength shifter of pump, and wherein this single quasi-phase-matching crystals is to be one-period property lattice polarization counter-rotating lithium niobate (PPLN) crystal, it is two tandem grating period ranges arranged side by side again, wherein the grating cycle of first its first grating period range of row is to be 29.7 microns, and the grating cycle of its second grating period range is to be 11.3 microns; And the grating cycle of its first grating period range of secondary series is to be 30.5 microns, and the grating cycle of its second grating period range is to be 12.4 microns.

According to above-mentioned conception, this laser pump source can be 1.064 microns laser light of a Nd-doped yttrium vanadate (Nd:YVO) laser emission wavelength in the laser system device, be used for this wavelength shifter of pump, and wherein this single quasi-phase-matching crystals is to be one-period property lattice polarization counter-rotating lithium niobate (PPLN) crystal, it is two tandem grating period ranges arranged side by side again, wherein the grating cycle of first its first grating period range of row is to be 29.7 microns, and the grating cycle of its second grating period range is to be 11.3 microns; And the grating cycle of its first grating period range of secondary series is to be 30.5 microns, and the grating cycle of its second grating period range is to be 12.4 microns.

A kind of laser system device according to a further aspect of the invention, particularly be applicable to medical science optical dynamic therapy (PDT) and diagnose (PDD) to use LASER Light Source, this laser system device comprises: a laser pump source, it launches at least one specific laser light wavelength, is used for the intrasystem laser gain body of pump one laser resonator; One laser gain body is used to absorb specific wavelength laser light that this laser pump source launches and can be because of being excited to excite the photon that produces another specific wavelength.One wavelength shifter, it utilizes accurate phase matched (QPM) technology, is used to change the specific light wavelet that this laser gain body is excited to excite and grows to the photon wavelength that at least one is applicable to optical dynamic therapy (PDT) and diagnosis (PDD) usefulness; One laser resonator system, its system is built-in with this laser gain body and this wavelength shifter, is used to resonate produce the specific wavelength laser that this laser gain body is excited to amplify and produce the laser light wavelength that is applicable to optical dynamic therapy (PDT) and diagnosis (PDD) usefulness with this laser this wavelength shifter of pump in system behind this laser pump source pump export with intensity; And an optical delivery follower, it is used to receive and transmit the laser light of this laser resonator system output, and by its terminal optics output device, at least one specific objective point output is shone.

According to above-mentioned conception, also comprise a lens coupling system in the laser system device between this laser resonator system and this optical delivery follower, it is to have at least one lens, and the laser light that is used for this laser resonator system output of effective coupling enters an optical delivery follower.

According to above-mentioned conception, this laser resonator system is the straight formula resonant cavity that can be made up of a pair of laser mirror in the laser system device, and it is to be used for resonance to produce at least one laser light wavelength and power that is applicable to optical dynamic therapy (PDT) and diagnosis (PDD) usefulness.

According to above-mentioned conception, in the laser system device this laser resonator system be can by one be arranged at this laser gain body the laser pump end face suitable reflection or penetrate optics dielectric mirror coating and a laser mirror and the straight formula resonant cavity formed, it is to be used for resonance to produce at least one laser light wavelength and power that is applicable to optical dynamic therapy (PDT) and diagnosis (PDD) usefulness.

According to above-mentioned conception, this laser resonator system can or penetrate optics dielectric mirror coating and the straight formula resonant cavity formed by the suitable reflection of the laser output face of a pair of laser pump end face that is arranged at this laser gain body respectively and the employed quasi-phase-matching crystals of this wavelength shifter in the laser system device, and it is to be used for resonance to produce at least one laser light wavelength and power that is applicable to optical dynamic therapy (PDT) and diagnosis (PDD) usefulness.

According to above-mentioned conception, outer another laser mirror of this straight formula resonant cavity of this laser resonator system formula resonant cavity coupling always forms another non co axial formula resonant cavity in the laser system device, be used to resonate and place this laser gain body in this non co axial formula resonant cavity to produce a specific wavelength laser, this specific wavelength laser is in its straight formula resonant cavity of passing through the time, be to change with straight this wavelength shifter of formula resonance direction of principal axis pump to produce at least one laser light wavelength that is applicable to optical dynamic therapy (PDT) and diagnosis (PDD) usefulness, its power also amplifies in this straight formula resonant cavity internal resonance.

According to above-mentioned conception, another outer laser mirror of its straight formula resonant cavity of this laser resonator system can be one be arranged at this laser gain body the laser pump end face suitable reflection or penetrate optics dielectric mirror coating.

According to above-mentioned conception, the ring type resonant cavity that this laser resonator system can be made up of four laser mirrors in the laser system device, it is to be used for unidirectional resonance to produce at least one laser light wavelength and power that is applicable to optical dynamic therapy (PDT) and diagnosis (PDD) usefulness.

According to above-mentioned conception, this laser pump source can be how rice laser light of semiconductor laser emission wavelength 808 in the laser system device, be used for this laser gain body of pump, be to be 1.064 microns laser light of a neodymium-doped yttrium-aluminum garnet (Nd:YAG) crystal emission wavelength, be used for this wavelength shifter of pump, and wherein this single quasi-phase-matching crystals is to be one-period property lattice polarization counter-rotating lithium niobate (PPLN) crystal, wherein the grating cycle of this first grating period range is to be 29.7 microns again, and the grating cycle of this second grating period range is to be 11.3 microns.

According to above-mentioned conception, this laser pump source can be how rice laser light of semiconductor laser emission wavelength 809 in the laser system device, be used for this laser gain body of pump, be to be 1.064 microns laser light of a Nd-doped yttrium vanadate (Nd:YVO4) crystal emission wavelength, be used for this wavelength shifter of pump, and wherein this single quasi-phase-matching crystals is to be one-period property lattice polarization counter-rotating lithium niobate (PPLN) crystal, wherein the grating cycle of this first grating period range is to be 29.7 microns again, and the grating cycle of this second grating period range is to be 11.3 microns.

According to above-mentioned conception, this laser pump source can be how rice laser light of semiconductor laser emission wavelength 808 in the laser system device, be used for this laser gain body of pump, be to be 1.064 microns laser light of a neodymium-doped yttrium-aluminum garnet (Nd:YAG) crystal emission wavelength, be used for this wavelength shifter of pump, and wherein this single quasi-phase-matching crystals is to be one-period property lattice polarization counter-rotating lithium niobate (PPLN) crystal, wherein the grating cycle of this first grating period range is to be 30.5 microns again, and the grating cycle of this second grating period range is to be 12.4 microns.

According to above-mentioned conception, this laser pump source can be how rice laser light of semiconductor laser emission wavelength 809 in the laser system device, be used for this laser gain body of pump, be to be 1.064 microns laser light of a Nd-doped yttrium vanadate (Nd:YVO4) crystal emission wavelength, be used for this wavelength shifter of pump, and wherein this single quasi-phase-matching crystals is to be one-period property lattice polarization counter-rotating lithium niobate (PPLN) crystal, wherein the grating cycle of this first grating period range is to be 30.5 microns again, and the grating cycle of this second grating period range is to be 12.4 microns.

According to above-mentioned conception, this laser pump source can be how rice laser light of semiconductor laser emission wavelength 808 in the laser system device, be used for this laser gain body of pump, be to be 1.064 microns laser light of a neodymium-doped yttrium-aluminum garnet (Nd:YAG) crystal emission wavelength, be used for this wavelength shifter of pump, and wherein this single quasi-phase-matching crystals is to be one-period property lattice polarization counter-rotating lithium niobate (PPLN) crystal, wherein the grating cycle of this first grating period range is at the 29.7-30.5 micrometer range again, the grating cycle of this second grating period range is to be 11.3 microns, and the grating cycle of another the 3rd grating period range is to be 12.4 microns.

According to above-mentioned conception, this laser pump source can be how rice laser light of semiconductor laser emission wavelength 809 in the laser system device, be used for this laser gain body of pump, be to be 1.064 microns laser light of a Nd-doped yttrium vanadate (Nd:YVO4) crystal emission wavelength, be used for this wavelength shifter of pump, and wherein this single quasi-phase-matching crystals is to be one-period property lattice polarization counter-rotating lithium niobate (PPLN) crystal, wherein the grating cycle of this first grating period range is at the 29.7-30.5 micrometer range again, the grating cycle of this second grating period range is to be 11.3 microns, and the grating cycle of another the 3rd grating period range is to be 12.4 microns.

According to above-mentioned conception, this laser pump source can be how rice laser light of semiconductor laser emission wavelength 808 in the laser system device, be used for this laser gain body of pump, be to be 1.064 microns laser light of a neodymium-doped yttrium-aluminum garnet (Nd:YAG) crystal emission wavelength, be used for this wavelength shifter of pump, and wherein this single quasi-phase-matching crystals is to be one-period property lattice polarization counter-rotating lithium niobate (PPLN) crystal, it is two tandem grating period ranges arranged side by side again, wherein the grating cycle of first its first grating period range of row is to be 29.7 microns, and the grating cycle of its second grating period range is to be 11.3 microns; And the grating cycle of its first grating period range of secondary series is to be 30.5 microns, and the grating cycle of its second grating period range is to be 12.4 microns.

According to above-mentioned conception, this laser pump source can be how rice laser light of semiconductor laser emission wavelength 809 in the laser system device, be used for this laser gain body of pump, be to be 1.064 microns laser light of a Nd-doped yttrium vanadate (Nd:YVO4) crystal emission wavelength, be used for this wavelength shifter of pump, and wherein this single quasi-phase-matching crystals is to be one-period property lattice polarization counter-rotating lithium niobate (PPLN) crystal, it is two tandem grating period ranges arranged side by side again, wherein the grating cycle of first its first grating period range of row is to be 29.7 microns, and the grating cycle of its second grating period range is to be 11.3 microns; And the grating cycle of its first grating period range of secondary series is to be 30.5 microns, and the grating cycle of its second grating period range is to be 12.4 microns.

A kind of laser system device according to a further aspect of the present invention, particularly be applicable to medical science optical dynamic therapy (PDT) and diagnose (PDD) to use LASER Light Source, this laser system device is to comprise: a laser pump source, and it is at least one specific laser light wavelength of emission, is used for pump one wavelength shifter; One wavelength shifter, it is to utilize accurate phase matched (QPM) technology, be used to change specific laser light wavelength that this laser pump source launches at least one be applicable to the laser light wavelength of optical dynamic therapy (PDT) and diagnosis (PDD) usefulness; And an optical delivery follower, it is the laser light that is used to receive and transmit this laser resonator system output, and by its terminal optics output device, at least one specific objective point output is shone.

According to above-mentioned conception, also comprise at least one coupling lens in the laser system device between this laser pump source and this wavelength shifter, so that this laser pump source is able to enter this laser resonator system via these at least one coupling lens.

According to above-mentioned conception, these coupling lens optionally are coated with pumping optical wavelength anti-reflective film and have the specific curvature focal length in the laser system device, enter this wavelength shifter with the pump energy that receives with this laser pump source of coupling.

According to above-mentioned conception, can optical fiber pigtail (fiber pigtail) technology coupling between this wavelength shifter and this optical delivery follower in the laser system device.

According to above-mentioned conception, also comprise a lens coupling system in the laser system device between this wavelength shifter and this optical delivery follower, it is to have at least one lens, and the laser light that is used for this wavelength shifter output of effective coupling enters an optical delivery follower.

According to above-mentioned conception, its framework of laser system device can be phase matched optical parameter generation (OPG) device surely, is used to produce at least one laser light wavelength and power that is applicable to optical dynamic therapy (PDT) and diagnosis (PDD) usefulness.

According to above-mentioned conception, its framework of laser system device can be phase matched optical parametric oscillation (OPO) device tandem one non-linear wavelength transducer surely, is used to produce at least one laser light wavelength and power that is applicable to optical dynamic therapy (PDT) and diagnosis (PDD) usefulness.

According to above-mentioned conception, in the laser system device this wavelength shifter also comprise a quasi-phase-matching crystals as accurate phase matched optical parameter produce (OPG) gain body, at least one quasi-phase-matching crystals is as non-linear wavelength conversion gain body in addition.

According to above-mentioned conception, in the laser system device this wavelength shifter also comprise a quasi-phase-matching crystals as accurate phase matched optical parameter produce (OPG) gain body, at least one nonlinear crystal is as non-linear wavelength conversion gain body in addition.

According to above-mentioned conception, this wavelength shifter can be a single quasi-phase-matching crystals in the laser system device, and it comprises a plurality of different grating cycles and is made side by side, so that (OPG) gain body to be provided as the optical parameter that provides multiple accurate phase matched mode to select.

According to above-mentioned conception, this single quasi-phase-matching crystals, also include a plurality of different grating periodic region between its arbitrary row grating periodic region, so that the gain body that (OPG) gain body and multiple non-linear wavelength conversion regime are selected to be provided as the optical parameter that provides multiple accurate phase matched mode to select.

According to above-mentioned conception, this wavelength shifter can be a single quasi-phase-matching crystals in the laser system device, it comprises a plurality of different grating period range tandems and is made, wherein one first grating period range as accurate phase matched optical parameter produce (OPG) gain body, second or other grating period ranges as non-linear wavelength conversion gain body.

According to above-mentioned conception, this laser pump source can be 1.064 microns laser light of a Nd-doped yttrium vanadate (Nd:YVO4) laser emission wavelength in the laser system device, be used for this wavelength shifter of pump, and wherein this single quasi-phase-matching crystals is to be one-period property lattice polarization counter-rotating lithium niobate (PPLN) crystal, it is two tandem grating period ranges arranged side by side again, wherein the grating cycle of first its first grating period range of row is to be 29.7 microns, and the grating cycle of its second grating period range is to be 11.3 microns; And the grating cycle of its first grating period range of secondary series is to be 30.5 microns, and the grating cycle of its second grating period range is to be 12.4 microns.

(4) description of drawings

The present invention can obtain a more deep understanding by following accompanying drawing and detailed description.

Fig. 1 is optical dynamic therapy of the present invention and diagnosis laser system device schematic diagram.

Fig. 2 is the first preferred construction illustration intention of quasi-phase-matching crystals in optical dynamic therapy of the present invention and the diagnosis laser system.

Fig. 3 is the second preferred construction illustration intention of quasi-phase-matching crystals in optical dynamic therapy of the present invention and the diagnosis laser system.

Fig. 4 is the 3rd preferred construction illustration intention of quasi-phase-matching crystals in optical dynamic therapy of the present invention and the diagnosis laser system.

Fig. 5 is the first preferred embodiment schematic diagram of optical dynamic therapy of the present invention and diagnosis laser system.

Fig. 6 is the second preferred embodiment schematic diagram of optical dynamic therapy of the present invention and diagnosis laser system.

Fig. 7 is the 3rd a preferred embodiment schematic diagram of optical dynamic therapy of the present invention and diagnosis laser system.

Fig. 8 is the 4th a preferred embodiment schematic diagram of optical dynamic therapy of the present invention and diagnosis laser system.

(5) embodiment

Optical dynamic therapy that the present invention discloses and diagnosis laser system device are as shown in Figure 1, comprise a laser system 2, a lens coupling system 8 and an

optical delivery follower

10,12 at least.Wherein this laser system 2 is made up of a pumping light 4, coupling lens 5 and a wavelength shifter 6.This wavelength shifter 6 is to be used to change extremely at least one laser light wavelength that is applicable to optical dynamic therapy (PDT) or diagnosis (PDD) usefulness of specific wavelength that this pumping light 4 is launched.The laser light that this conversion produces focuses on the photostyle system 12 that the optical fiber 10 that enters this optical delivery follower transfers to this optical delivery follower effectively via this lens coupling system 8 again and does to export specific impact point to after the suitable focusing, for example imposes the tumor tissues of photosensitive drug.This optical dynamic therapy and diagnosis laser system device also can be save this lens coupling system 8, and export this

optical delivery follower

10,12 to the laser of this laser system 2 of the direct coupling of optical fiber pigtail (fiber pigtail) technology.

Please refer to Fig. 2 to Fig. 4, it is the preferred construction example of the quasi-phase-matching crystals 14,20,28 that adopted of the wavelength shifter 6 of optical dynamic therapy of the present invention and diagnosis laser system device.Please refer to Fig. 2, this quasi-phase-matching crystals 14 is the quasi-phase-matching crystals in a monolithic (monolithic) tandem formula grating cycle, and it is that quasi-phase-matching crystals by one first grating periodic region 16 and one second grating periodic region 18 is constituted.The accurate phase matched optical grating periodic structure of this tandem formula is to realize changing the extremely at least a laser light wavelength that is applicable to optical dynamic therapy (PDT) or diagnosis (PDD) usefulness of specific wavelength that this pumping light 4 is launched with two kinds of non-linear wavelength transfer processes that continue.When reality is implemented, this quasi-phase-matching crystals 14 can be one-period property lattice polarization counter-rotating lithium niobate (PPLN) crystal, the lattice polarization returing cycle of this first grating periodic region 16 can be 29.7 microns, to be to be the 1064 optical parameter gain bodies of rice how as a pumping optical wavelength, produce a wavelength and be how signal (signal) light of rice and wavelength that one is supervened are to be 3334.1 idle (idler) light of rice how for 1562.7.And the lattice polarization returing cycle of this second grating periodic region 18 can be 11.3 microns, to produce the nonlinear optical medium of (SFG) as a sum of fundamental frequencies, produce by this wavelength 1064 wavelength 633 Mi Guang how of the how meter photosynthetic frequency of signal (signal) of this wavelength of producing of pump laser light and this first grating periodic region, 16 optical parameters of rice 1562.7 how.How rice only is applicable to one of laser light wavelength of sensitising agent such as the optical dynamic therapy (PDT) that excites five-aminolevulinic acid or blood derivative to this wavelength 633.In addition, under above-mentioned enforcement framework, the lattice polarization returing cycle of this first grating periodic region 16 can be 30.5 microns again, thinks that optical parameter produces how signal (signal) light of rice of wavelength 1683.8.And the lattice polarization returing cycle of this second grating periodic region 18 can be 12.4 microns, the sum of fundamental frequencies of thinking this pump light and this flashlight produces how Mi Guang of wavelength 652, be for another optical dynamic therapy (PDT) that is applicable to another photaesthesia material Foscan with one of laser light wavelength.

Referring again to Fig. 3, the wavelength shifter 6 of laser system device of the present invention, the preferable enforcement structure of another of the quasi-phase-matching crystals that it adopted is to be the quasi-phase-matching crystals in a monolithic (monolithic) tandem formula grating cycle for this quasi-phase-matching crystals 20, and it is that quasi-phase-matching crystals by one first grating periodic region 22, one second grating periodic region 24 and one the 3rd grating periodic region 26 is constituted.The accurate phase matched optical grating periodic structure of this tandem formula is to realize changing the extremely at least a laser light wavelength that is applicable to optical dynamic therapy (PDT) or diagnosis (PDD) usefulness of specific wavelength that this pumping light 4 is launched with at least two kinds of non-linear wavelength transfer processes that continue.When reality is implemented, this quasi-phase-matching crystals 20 can be one-period property lattice polarization counter-rotating lithium niobate (PPLN) crystal, the lattice polarization returing cycle of this first grating periodic region 22 can be between 29.7 to 30.5 microns, being to be the 1064 optical parameter gain bodies of rice how as a pumping optical wavelength, and to produce a wavelength when one first temperature of this quasi-phase-matching crystals 20 be that how to produce a wavelength when rice or one second temperature be that how signal (signal) light of rice and wavelength that one is supervened are to be 3334.1 rice (in this first temperature time) or 2890.6 idle (idler) light of rice (in this second temperature time) how how for 1683.8 for 1562.7.And the lattice polarization returing cycle of this second grating periodic region 24 can be 11.3 microns, to produce the nonlinear optical medium of (SFG) as a sum of fundamental frequencies, produce by this wavelength 1064 wavelength 633 Mi Guang how of the how meter photosynthetic frequency of signal (signal) of this wavelength of producing of pump laser light and this first grating periodic region 22 optical parameter when this first temperature of rice 1562.7 how.And the lattice polarization returing cycle of the 3rd grating periodic region 26 can be 12.4 microns, to produce the nonlinear optical medium of (SFG) as a sum of fundamental frequencies, produce by this wavelength 1064 wavelength 652 Mi Guang how of the how meter photosynthetic frequency of signal (signal) of this wavelength of producing of pump laser light and this first grating periodic region 22 optical parameter when this second temperature of rice 1683.8 how.This wavelength 633 how rice with 652 how rice is only as the above-mentioned laser light wavelength that is applicable to optical dynamic therapy (PDT) usefulness.

Referring again to Fig. 4, the wavelength shifter 6 of laser system device of the present invention, the another preferable enforcement structure of the quasi-phase-matching crystals that it adopted is for this quasi-phase-matching crystals 28 is a monolithic (monolithic) quasi-phase-matching crystals in block form grating cycle, and it is to be made of side by side on monolithic crystal with aforesaid quasi-phase-matching crystals 14 structures a plurality of.Obvious, the accurate phase matched optical grating periodic structure of this block form, its arbitrary row are the quasi-phase-matching crystals 14 for a single tandem formula grating cycle, and the function of this structure, principle and practicing describes in detail as precedent, do not repeat them here.When reality was implemented, the lattice polarization returing cycle of one first row one, the first grating periodic region of this quasi-phase-matching crystals 28 can be 29.7 microns, and the lattice polarization returing cycle of the one second grating periodic region can be 11.3 microns.The lattice polarization returing cycle of a secondary series one first grating periodic region of quasi-phase-matching crystals 28 can be 30.5 microns again, and the lattice polarization returing cycle of the one second grating periodic region can be 12.4 microns.Described according to precedent, the specific wavelength of being launched in this pumping light 4 is for 1064 how during rice, and it is that 633 how rice and a wavelength are 652 laser light of rice how that these first row of incident and this secondary series of incident will produce a wavelength respectively.Because of the quasi-phase-matching crystals 28 in this block form grating cycle, it is that quasi-phase-matching crystals 14 by a plurality of tandem formula grating cycles is constituted, and it can produce a plurality of laser light wavelength that are applicable to optical dynamic therapy (PDT) or diagnosis (PDD) usefulness.

The quasi-phase-matching

crystals

14,20,28 of disclosed structure, its advantage is to utilize designing and processing characteristics of accurate phase matched structure, and it is original and be not suitable for optical dynamic therapy (PDT) or diagnosis (PDD) to be changed the specific wavelength of its emission of arbitrary obtainable pumping light.Therefore, the present invention will make, and pumping radiant high-quality, appropriate power is not subject to the deficiency of wavelength and traditional non-linear wavelength transfer capability of its original particular transmission, be applied in optical dynamic therapy and the diagnosis, promoted the accuracy of diagnosis and the popularity and the completeness of sensitivity and treatment.

Please refer to Fig. 5 to Fig. 8, it is the preferred embodiment of this laser system 2 in optical dynamic therapy of the present invention and the diagnosis laser system device.As previously mentioned, this laser system 2 is made up of this pumping light 4 and this wavelength shifter 6.And this wavelength shifter 6, its preferable enforcement structure is with 14,20,28 formations of quasi-phase-matching crystals, is used to change extremely at least one laser light wavelength that is applicable to optical dynamic therapy (PDT) or diagnosis (PDD) usefulness of specific wavelength that this pumping light 4 is launched.In the preferred embodiment of laser system that Fig. 5 to Fig. 8 lifts 2, a wavelength shifter 39,51,63,79 also comprises a laser resonator system and is used to increase a quasi-phase-matching crystals 44,56,72,90 is applicable to optical dynamic therapy (PDT) or diagnosis (PDD) usefulness via coupling lens 43,55,71,87 suitable boundling pumps generations through a pumping light 38,50,62,78 laser light intensity output.The straight formula resonant cavity that this laser resonator system can be made up of a pair of laser resonator mirror 40,42, as shown in Figure 5, or by the suitable reflection of a pair of laser pump end face that is arranged at this quasi-phase-matching crystals 56 respectively and laser output face or penetrate optics dielectric mirror coating 52,54 and the straight formula resonant cavity formed, as shown in Figure 6.This laser resonator system is used to resonate this quasi-phase-matching crystals 44,56 through at least one laser light wavelength of this pumping light 38,50 via coupling lens 43,55 suitable boundling pumps generations.When the enforcement structure of this quasi-phase-matching crystals 44,56 is identical with aforementioned quasi-phase-matching crystals 14,20,28 or it is when similar; The embodiment of this quasi-phase-matching crystals 14,20,28 explanation as described above, the laser light wavelength that this resonance produces can produce at least one laser light wavelength that is applicable to optical dynamic therapy (PDT) or diagnosis (PDD) usefulness through another non-linear wavelength transfer process of this quasi-phase-matching crystals 44,56.Again in the present embodiment, this quasi-phase-matching crystals the 44, the 56th is placed on the temperature controller 46,58, make its crystal temperature effect be able to modulation and be controlled at least one definite value, be used for accurately producing at least one laser light wavelength that is applicable to optical dynamic therapy (PDT) or diagnosis (PDD) usefulness.This temperature controller 46,58 is placed on the platform of 48,60 transmissions of one micron driver especially, makes the multiple grating periodic structure of this quasi-phase-matching crystals 44,56; Particularly such as the quasi-phase-matching crystals 28 of act block form grating periodic structure, be able to be produced in regular turn the multiple one laser light wavelength that is applicable to optical dynamic therapy (PDT) or diagnosis (PDD) usefulness by pump in regular turn.

Fig. 7 is another preferred embodiment of the laser system of lifting 2, the ring type resonant cavity be made up of four laser mirrors 64,66,68,70 of the laser resonator system that comprised of this wavelength shifter 63 wherein, it is to be used at least one laser light wavelength that this quasi-phase-matching crystals 72 of unidirectional resonance produces through these pumping light 62 pumps.Employed pumping light 62 in this preferred embodiment, coupling lens 71, quasi-phase-matching crystals 72, temperature controller 74, micron driver 76, its function, principle and practice all described identically with last example do not repeat them here.

In above-mentioned illustrated embodiment, straight formula resonant cavity is comparatively simple because of system, so advantages such as lower system loss and pump valve value are arranged.And the ring type resonant cavity is because of using the four sides laser mirror, and the system loss rate is higher, so the pump valve value also uprises, yet its distinct advantages is to be output as high-quality single longitudinal mode light, laser linewidth approximately can tens of times less than straight formula resonant cavity system.

Fig. 8 is the another preferred embodiment of the laser system of lifting 2, the resonant cavity of formula always be made up of a pair of laser resonator mirror 84,86 of the laser resonator system that comprised of this wavelength shifter 79 wherein, outer another laser mirror 82 of this straight formula resonant cavity of its coupling form another non co axial formula resonant cavities (that is be made up of 82,84 of laser mirrors).This non co axial formula resonant cavity is to be used to resonate the specific wavelength laser of a laser gain body 80 through this pumping light 78 pumps generation.Via a specific wavelength speculum 88, this specific wavelength laser is in this straight formula resonant cavity of passing through the time, be to change with straight this quasi-phase-matching crystals 90 of formula resonance direction of principal axis pump to produce at least one laser light wavelength that is applicable to optical dynamic therapy (PDT) and diagnosis (PDD) usefulness, its power also amplifies in this straight formula resonant cavity internal resonance.Employed coupling lens 87 in this preferred embodiment, quasi-phase-matching crystals 90, temperature controller 92, micron driver 94, its function, principle and practice all described identically with last example do not repeat them here.

In addition, because of preferred embodiment that Fig. 8 lifted is with this quasi-phase-matching crystals 90 of pump mode pump in the so-called chamber, compared to earlier figures 5 to the preferred embodiment that Fig. 7 lifted is with pump mode outside the chamber, and its advantage is that system is lower to the demand of integral pump power, so conversion efficiency is higher.But also because of this preferable enforcement structure comprises a non co axial formula resonant cavity, more general straight formula resonant cavity complexity of structure and system also will be difficult to light.

When reality is implemented, this pumping light 38,50,62 can be the how neodymium-doped laser of rice of one about 11 watts, wavelength 1064, or this pumping light 78 can be the how semiconductor laser of rice of about 25 watts, wavelength 808, and this laser gain body 80 can be a neodymium-doped laser crystal (as the neodymium-doped yttrium-aluminum garnet crystal).Quasi-phase-matching crystals 44,56,72,90 in this wavelength Conversion 39,51,63,79 can be the structure of this quasi-phase-matching crystals 14 again, when the lattice polarization returing cycle of its first grating periodic region 16 is that 29.7 microns, length are five centimeters, and the lattice polarization returing cycle of its second grating periodic region 18 be 11.3 microns, when length is one centimeter, this laser system 2 will produce about 2 watts 633 rice laser light how, and it is laser light wavelength and the power that is applicable to optical dynamic therapy (PDT) usefulness.

In sum, the invention provides a kind of laser system device, utilize quasi-phase matching to realize that the laser of wavelength Conversion and wavelength-tunable produces, and increase output power of laser intensity with the laser resonator system of clever thought design, really met the lasing light emitter requirement of the thirsty high-quality wavelength-tunable that needs of medical light power diagnosis and photodynamic therapy system, have contribution for the accuracy that promotes diagnosis and the popularity and the completeness of sensitivity and treatment, therefore can realize developing purpose of the present invention.

Claims

1. laser system device is applicable to that particularly medical science optical dynamic therapy and diagnosis use LASER Light Source, it is characterized in that this laser system device comprises:

One laser pump source is launched at least one specific laser light wavelength, is used for the intrasystem wavelength shifter of pump one laser resonator;

One wavelength shifter, it is to utilize quasi-phase matching, be used to change specific laser light wavelength that this laser pump source launches at least one be applicable to the laser light wavelength of optical dynamic therapy and diagnosis usefulness;

One laser resonator system, its chamber is built-in with this wavelength shifter, is used to increase this wavelength shifter and produces the laser light intensity output that is applicable to optical dynamic therapy and diagnosis usefulness through this laser pump source pump; And

One optical delivery follower is used to receive and transmit the laser light of this laser resonator system output, and by its terminal optics output device, at least one specific objective point output is shone.

2. laser system device as claimed in claim 1 is characterized in that:

Also comprise at least one coupling lens between this laser pump source and this laser resonator system, so that this laser pump source is able to enter this laser resonator system via these at least one coupling lens, and these coupling lens optionally are coated with pumping optical wavelength anti-reflective film and have the specific curvature focal length, enter this laser resonator system with the pump energy that receives with this laser pump source of coupling;

This optical delivery follower, it is made up of as laser output institute as laser transmission and at least one light pen at least one optical fiber, and is with the coupling of optical fiber pigtail technology between this laser resonator system and this optical delivery follower; And/or

Also comprise a lens coupling system between this laser resonator system and this optical delivery follower, it has at least one lens, the laser light that is used for this laser resonator system output of effective coupling enters this optical delivery follower, and is with the coupling of optical fiber pigtail technology between this lens coupling system and this optical delivery follower.

3. laser system device as claimed in claim 1 is characterized in that, this wavelength shifter:

Constituted by at least one quasi-phase-matching crystals;

Constituted by an at least one quasi-phase-matching crystals and a temperature regulator, be used to regulate and control this quasi-phase-matching crystals in specified temp;

Constituted by at least one quasi-phase-matching crystals and one micron driver, be used to choose the non-linear wavelength conversion of this quasi-phase-matching crystals grating periodic region intercropping wherein; Or

Constituted by at least one quasi-phase-matching crystals, a temperature regulator and one micron driver, be used to regulate and control this quasi-phase-matching crystals, and be used to choose the non-linear wavelength conversion of this quasi-phase-matching crystals grating periodic region intercropping wherein in specified temp.

4. laser system device as claimed in claim 1 is characterized in that, this laser resonator system:

By the straight formula resonant cavity that a pair of laser mirror is formed, it is to be used to resonate at least one laser light wavelength and power that is applicable to optical dynamic therapy and diagnosis usefulness of generation;

Be arranged at by a laser mirror and the employed quasi-phase-matching crystals of this wavelength shifter the laser output face suitable reflection or penetrate optics dielectric mirror coating and the straight formula resonant cavity formed, it is to be used to resonate produce at least one laser light wavelength and power that is applicable to optical dynamic therapy and diagnosis usefulness;

By one be arranged at the employed quasi-phase-matching crystals of this wavelength shifter the laser pump end face suitable reflection or penetrate optics dielectric mirror coating and a laser mirror and the straight formula resonant cavity formed, it is to be used to resonate produce at least one laser light wavelength and power that is applicable to optical dynamic therapy and diagnosis usefulness;

By the suitable reflection of a pair of laser pump end face that is arranged at the employed quasi-phase-matching crystals of this wavelength shifter respectively and laser output face or penetrate optics dielectric mirror coating and the straight formula resonant cavity formed, it is to be used to resonate produce at least one laser light wavelength and power that is applicable to optical dynamic therapy and diagnosis usefulness; Or

By the ring type resonant cavity that four laser mirrors are formed, it is to be used for unidirectional resonance to produce at least one laser light wavelength and power that is applicable to optical dynamic therapy and diagnosis usefulness.

5. laser system device as claimed in claim 1 is characterized in that, the framework of this laser resonator system:

Be to be phase matched optical parametric oscillator surely, be used to produce at least one laser light wavelength and power that is applicable to optical dynamic therapy and diagnosis usefulness, wherein the intrasystem wavelength shifter of this laser resonator is to be a single quasi-phase-matching crystals, it comprises a plurality of different grating cycles and is made side by side, with as the optical parametric oscillation gain body that provides multiple accurate phase matched mode to select; Or

Be to be phase matched optical parametric oscillator tandem one non-linear wavelength transducer surely, be used to produce at least one laser light wavelength and power that is applicable to optical dynamic therapy and diagnosis usefulness, and this non-linear wavelength transducer is to form with frequency doubling technology or sum of fundamental frequencies fabrication techniques, wherein the intrasystem wavelength shifter of this laser resonator is to be a single quasi-phase-matching crystals, it comprises a plurality of different grating period range tandems and is made, wherein one first grating period range is as accurate phase matched optical parametric oscillation gain body, second or other grating period ranges as non-linear wavelength conversion gain body, and this single quasi-phase-matching crystals, also include a plurality of different grating periodic region between its arbitrary row grating periodic region, with the gain body as optical parametric oscillation gain body that provides multiple accurate phase matched mode to select and multiple non-linear wavelength conversion regime selection, and wherein this wavelength shifter also comprises:

A quasi-phase-matching crystals is as accurate phase matched optical parametric oscillation gain body, and at least one quasi-phase-matching crystals is as non-linear wavelength conversion gain body in addition; Or

A quasi-phase-matching crystals is as accurate phase matched optical parametric oscillation gain body, and at least one nonlinear crystal is as non-linear wavelength conversion gain body in addition.

6. laser system device as claimed in claim 1 is characterized in that, the employed quasi-phase-matching crystals of this wavelength shifter is to be periodic lattice polarization reversal lithium columbate crystal, and this laser pump source:

Be to be 1.064 microns laser light of a nd yag doubled-frequency laser emission wavelength, be used for this wavelength shifter of pump, and wherein this single quasi-phase-matching crystals is to be one-period property lattice polarization counter-rotating lithium columbate crystal, wherein the grating cycle of this first grating period range is to be 29.7 microns again, and the grating cycle of this second grating period range is to be 11.3 microns;

Be to be 1.064 microns laser light of a Nd-doped yttrium vanadate laser emission wavelength, be used for this wavelength shifter of pump, and wherein this single quasi-phase-matching crystals is to be one-period property lattice polarization counter-rotating lithium columbate crystal, wherein the grating cycle of this first grating period range is to be 29.7 microns again, and the grating cycle of this second grating period range is to be 11.3 microns;

Be to be 1.064 microns laser light of a nd yag doubled-frequency laser emission wavelength, be used for this wavelength shifter of pump, and wherein this single quasi-phase-matching crystals is to be one-period property lattice polarization counter-rotating lithium columbate crystal, wherein the grating cycle of this first grating period range is to be 30.5 microns again, and the grating cycle of this second grating period range is to be 12.4 microns;

Be to be 1.064 microns laser light of a Nd-doped yttrium vanadate laser emission wavelength, be used for this wavelength shifter of pump, and wherein this single quasi-phase-matching crystals is to be one-period property lattice polarization counter-rotating lithium columbate crystal, wherein the grating cycle of this first grating period range is to be 30.5 microns again, and the grating cycle of this second grating period range is to be 12.4 microns;

Be to be 1.064 microns laser light of a nd yag doubled-frequency laser emission wavelength, be used for this wavelength shifter of pump, and wherein this single quasi-phase-matching crystals is to be one-period property lattice polarization counter-rotating lithium columbate crystal, wherein the grating cycle of this first grating period range is at the 29.7-30.5 micrometer range again, the grating cycle of this second grating period range is to be 11.3 microns, and the grating cycle of another the 3rd grating period range is to be 12.4 microns;

Be to be 1.064 microns laser light of a Nd-doped yttrium vanadate laser emission wavelength, be used for this wavelength shifter of pump, and wherein this single quasi-phase-matching crystals is to be one-period property lattice polarization counter-rotating lithium columbate crystal, wherein the grating cycle of this first grating period range is at the 29.7-30.5 micrometer range again, the grating cycle of this second grating period range is to be 11.3 microns, and the grating cycle of another the 3rd grating period range is to be 12.4 microns;

Be to be 1.064 microns laser light of a nd yag doubled-frequency laser emission wavelength, be used for this wavelength shifter of pump, and wherein this single quasi-phase-matching crystals is to be one-period property lattice polarization counter-rotating lithium columbate crystal, it is two tandem grating period ranges arranged side by side again, wherein the grating cycle of first its first grating period range of row is to be 29.7 microns, and the grating cycle of its second grating period range is to be 11.3 microns; And the grating cycle of its first grating period range of secondary series is to be 30.5 microns, and the grating cycle of its second grating period range is to be 12.4 microns; Or

Be to be 1.064 microns laser light of a Nd-doped yttrium vanadate laser emission wavelength, be used for this wavelength shifter of pump, and wherein this single quasi-phase-matching crystals is to be one-period property lattice polarization counter-rotating lithium columbate crystal, it is two tandem grating period ranges arranged side by side again, wherein the grating cycle of first its first grating period range of row is to be 29.7 microns, and the grating cycle of its second grating period range is to be 11.3 microns; And the grating cycle of its first grating period range of secondary series is to be 30.5 microns, and the grating cycle of its second grating period range is to be 12.4 microns.

7. laser system device is applicable to that particularly medical science optical dynamic therapy and diagnosis use LASER Light Source, it is characterized in that this laser system device comprises:

One laser pump source is launched at least one specific laser light wavelength, is used for the intrasystem laser gain body of pump one laser resonator;

One laser gain body is used to absorb specific wavelength laser light that this laser pump source launches and can be because of being excited to excite the photon that produces another specific wavelength.

One wavelength shifter, it is to utilize quasi-phase matching, is used to change the specific light wavelet that this laser gain body is excited to excite and grows to the photon wavelength that at least one is applicable to optical dynamic therapy and diagnosis usefulness:

One laser resonator system, its system is built-in with this laser gain body and this wavelength shifter, is used to resonate produce the specific wavelength laser that this laser gain body is excited to amplify and produce the laser light wavelength that is applicable to optical dynamic therapy and diagnosis usefulness with this laser this wavelength shifter of pump in system behind this laser pump source pump export with intensity; And

One optical delivery follower, it is the laser light that is used to receive and transmit this laser resonator system output, and by its terminal optics output device, at least one specific objective point output irradiation.

8. laser system device as claimed in claim 7 is characterized in that, this laser resonator system:

By one be arranged at this laser gain body the laser pump end face suitable reflection or penetrate optics dielectric mirror coating and a laser mirror and the straight formula resonant cavity formed, it is to be used to resonate produce at least one laser light wavelength and power that is applicable to optical dynamic therapy and diagnosis usefulness;

By the suitable reflection of the laser output face of a pair of laser pump end face that is arranged at this laser gain body respectively and the employed quasi-phase-matching crystals of this wavelength shifter or penetrate optics dielectric mirror coating and the straight formula resonant cavity formed, it is to be used to resonate produce at least one laser light wavelength and power that is applicable to optical dynamic therapy and diagnosis usefulness; Or

Be to form another non co axial formula resonant cavity with outer another laser mirror of this straight formula resonant cavity of formula resonant cavity coupling always, be used to resonate and place this laser gain body in this non co axial formula resonant cavity to produce a specific wavelength laser, this specific wavelength laser is in its straight formula resonant cavity of passing through the time, be to change with straight this wavelength shifter of formula resonance direction of principal axis pump to produce at least one laser light wavelength that is applicable to optical dynamic therapy and diagnosis usefulness, its power also amplifies in this straight formula resonant cavity internal resonance, and

Another outer laser mirror of its straight formula resonant cavity of this laser resonator system be for one be arranged at this laser gain body the laser pump end face suitable reflection or penetrate optics dielectric mirror coating.

9. laser system device as claimed in claim 7 is characterized in that, the framework of this laser resonator system:

Be to be accurate phase matched optical parametric oscillator in the chamber, be used to produce at least one laser light wavelength and power that is applicable to optical dynamic therapy and diagnosis usefulness; Or

Be to be accurate phase matched optical parametric oscillator tandem one non-linear wavelength transducer in the chamber, be used to produce at least one laser light wavelength and power that is applicable to optical dynamic therapy and diagnosis usefulness.

10. laser system device as claimed in claim 7 is characterized in that, this laser pump source:

Be to be semiconductor laser emission wavelength 808 rice laser light how, be used for this laser gain body of pump, be to be 1.064 microns laser light of a neodymium-doped yttrium-aluminum garnet crystal emission wavelength, be used for this wavelength shifter of pump, and wherein this single quasi-phase-matching crystals is to be one-period property lattice polarization counter-rotating lithium columbate crystal, wherein the grating cycle of this first grating period range is to be 29.7 microns again, and the grating cycle of this second grating period range is to be 11.3 microns;

Be to be semiconductor laser emission wavelength 809 rice laser light how, be used for this laser gain body of pump, be to be 1.064 microns laser light of a Nd-doped yttrium vanadate crystal emission wavelength, be used for this wavelength shifter of pump, and wherein this single quasi-phase-matching crystals is to be one-period property lattice polarization counter-rotating lithium columbate crystal, wherein the grating cycle of this first grating period range is to be 29.7 microns again, and the grating cycle of this second grating period range is to be 11.3 microns;

Be to be semiconductor laser emission wavelength 808 rice laser light how, be used for this laser gain body of pump, be to be 1.064 microns laser light of a neodymium-doped yttrium-aluminum garnet crystal emission wavelength, be used for this wavelength shifter of pump, and wherein this single quasi-phase-matching crystals is to be one-period property lattice polarization counter-rotating lithium columbate crystal, wherein the grating cycle of this first grating period range is to be 30.5 microns again, and the grating cycle of this second grating period range is to be 12.4 microns;

Be to be semiconductor laser emission wavelength 809 rice laser light how, be used for this laser gain body of pump, be to be 1.064 microns laser light of a Nd-doped yttrium vanadate crystal emission wavelength, be used for this wavelength shifter of pump, and wherein this single quasi-phase-matching crystals is to be one-period property lattice polarization counter-rotating lithium columbate crystal, wherein the grating cycle of this first grating period range is to be 30.5 microns again, and the grating cycle of this second grating period range is to be 12.4 microns;

Be to be semiconductor laser emission wavelength 808 rice laser light how, be used for this laser gain body of pump, be to be 1.064 microns laser light of a neodymium-doped yttrium-aluminum garnet crystal emission wavelength, be used for this wavelength shifter of pump, and wherein this single quasi-phase-matching crystals is to be one-period property lattice polarization counter-rotating lithium columbate crystal, wherein the grating cycle of this first grating period range is at the 29.7-30.5 micrometer range again, the grating cycle of this second grating period range is to be 11.3 microns, and the grating cycle of another the 3rd grating period range is to be 12.4 microns;

Be to be semiconductor laser emission wavelength 809 rice laser light how, be used for this laser gain body of pump, be to be 1.064 microns laser light of a Nd-doped yttrium vanadate crystal emission wavelength, be used for this wavelength shifter of pump, and wherein this single quasi-phase-matching crystals is to be one-period property lattice polarization counter-rotating lithium columbate crystal, wherein the grating cycle of this first grating period range is at the 29.7-30.5 micrometer range again, the grating cycle of this second grating period range is to be 11.3 microns, and the grating cycle of another the 3rd grating period range is to be 12.4 microns;

Be to be semiconductor laser emission wavelength 808 rice laser light how, be used for this laser gain body of pump, be to be 1.064 microns laser light of a neodymium-doped yttrium-aluminum garnet crystal emission wavelength, be used for this wavelength shifter of pump, and wherein this single quasi-phase-matching crystals is to be one-period property lattice polarization counter-rotating lithium columbate crystal, it is two tandem grating period ranges arranged side by side again, wherein the grating cycle of first its first grating period range of row is to be 29.7 microns, and the grating cycle of its second grating period range is to be 11.3 microns; And the grating cycle of its first grating period range of secondary series is to be 30.5 microns, and the grating cycle of its second grating period range is to be 12.4 microns; Or

Be to be semiconductor laser emission wavelength 809 rice laser light how, be used for this laser gain body of pump, be to be 1.064 microns laser light of a Nd-doped yttrium vanadate crystal emission wavelength, be used for this wavelength shifter of pump, and wherein this single quasi-phase-matching crystals is to be one-period property lattice polarization counter-rotating lithium columbate crystal, it is two tandem grating period ranges arranged side by side again, wherein the grating cycle of first its first grating period range of row is to be 29.7 microns, and the grating cycle of its second grating period range is to be 11.3 microns; And the grating cycle of its first grating period range of secondary series is to be 30.5 microns, and the grating cycle of its second grating period range is to be 12.4 microns.

11. a laser system device, particularly be applicable to the medical science optical dynamic therapy and the diagnosis use LASER Light Source, it is characterized in that this laser system device comprises:

One laser pump source is launched at least one specific laser light wavelength, is used for pump one wavelength shifter;

One wavelength shifter, it is to utilize quasi-phase matching, be used to change specific laser light wavelength that this laser pump source launches at least one be applicable to the laser light wavelength of optical dynamic therapy and diagnosis usefulness; And

12. laser system device as claimed in claim 11 is characterized in that:

Also comprise at least one coupling lens between this laser pump source and this wavelength shifter, so that this laser pump source is able to enter this wavelength shifter via these at least one coupling lens;

Be with the coupling of optical fiber pigtail technology between this wavelength shifter and this optical delivery follower; And/or

Also comprise a lens coupling system between this wavelength shifter and this optical delivery follower, it has at least one lens, and the laser light that is used for this wavelength shifter output of effective coupling enters an optical delivery follower.

13. laser system device as claimed in claim 11, its framework is:

Surely phase matched optical parameter generator is used to produce at least one laser light wavelength and power that is applicable to optical dynamic therapy and diagnosis usefulness; Or

Surely phase matched optical parameter generator tandem one non-linear wavelength transducer is used to produce at least one laser light wavelength and power that is applicable to optical dynamic therapy and diagnosis usefulness.

14. laser system device as claimed in claim 13 is characterized in that:

This wavelength shifter is to be a single quasi-phase-matching crystals, it comprises a plurality of different grating cycles and is made side by side, so that the gain body to be provided as the optical parameter that provides multiple accurate phase matched mode to select, or be a single quasi-phase-matching crystals, it comprises a plurality of different grating period range tandems and is made, wherein one first grating period range produces the gain body as accurate phase matched optical parameter, second or other grating period ranges as non-linear wavelength conversion gain body, and this single quasi-phase-matching crystals, also include a plurality of different grating periodic region between its arbitrary row grating periodic region, so that the gain body that gain body and multiple non-linear wavelength conversion regime are selected to be provided as the optical parameter that provides multiple accurate phase matched mode to select;

This wavelength shifter also comprises a quasi-phase-matching crystals and produces the gain body as accurate phase matched optical parameter, and at least one quasi-phase-matching crystals is as non-linear wavelength conversion gain body in addition; Or

This wavelength shifter also comprises a quasi-phase-matching crystals and produces the gain body as accurate phase matched optical parameter, and at least one nonlinear crystal is as non-linear wavelength conversion gain body in addition.