CN1756577A - Apparatus and method for treatment of skin conditions - Google Patents
Apparatus and method for treatment of skin conditions Download PDFInfo
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- CN1756577A CN1756577A CNA2004800056603A CN200480005660A CN1756577A CN 1756577 A CN1756577 A CN 1756577A CN A2004800056603 A CNA2004800056603 A CN A2004800056603A CN 200480005660 A CN200480005660 A CN 200480005660A CN 1756577 A CN1756577 A CN 1756577A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/18—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
- A61B18/20—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser
- A61B18/203—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser applying laser energy to the outside of the body
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- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F21—LIGHTING
- F21V—FUNCTIONAL FEATURES OR DETAILS OF LIGHTING DEVICES OR SYSTEMS THEREOF; STRUCTURAL COMBINATIONS OF LIGHTING DEVICES WITH OTHER ARTICLES, NOT OTHERWISE PROVIDED FOR
- F21V29/00—Protecting lighting devices from thermal damage; Cooling or heating arrangements specially adapted for lighting devices or systems
- F21V29/50—Cooling arrangements
- F21V29/54—Cooling arrangements using thermoelectric means, e.g. Peltier elements
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N5/0613—Apparatus adapted for a specific treatment
- A61N5/0616—Skin treatment other than tanning
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- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F21—LIGHTING
- F21V—FUNCTIONAL FEATURES OR DETAILS OF LIGHTING DEVICES OR SYSTEMS THEREOF; STRUCTURAL COMBINATIONS OF LIGHTING DEVICES WITH OTHER ARTICLES, NOT OTHERWISE PROVIDED FOR
- F21V29/00—Protecting lighting devices from thermal damage; Cooling or heating arrangements specially adapted for lighting devices or systems
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- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F21—LIGHTING
- F21V—FUNCTIONAL FEATURES OR DETAILS OF LIGHTING DEVICES OR SYSTEMS THEREOF; STRUCTURAL COMBINATIONS OF LIGHTING DEVICES WITH OTHER ARTICLES, NOT OTHERWISE PROVIDED FOR
- F21V29/00—Protecting lighting devices from thermal damage; Cooling or heating arrangements specially adapted for lighting devices or systems
- F21V29/50—Cooling arrangements
- F21V29/51—Cooling arrangements using condensation or evaporation of a fluid, e.g. heat pipes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00005—Cooling or heating of the probe or tissue immediately surrounding the probe
- A61B2018/00011—Cooling or heating of the probe or tissue immediately surrounding the probe with fluids
- A61B2018/00023—Cooling or heating of the probe or tissue immediately surrounding the probe with fluids closed, i.e. without wound contact by the fluid
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00315—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for treatment of particular body parts
- A61B2018/00452—Skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N2005/0635—Radiation therapy using light characterised by the body area to be irradiated
- A61N2005/0643—Applicators, probes irradiating specific body areas in close proximity
- A61N2005/0644—Handheld applicators
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N2005/065—Light sources therefor
- A61N2005/0651—Diodes
- A61N2005/0652—Arrays of diodes
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- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F21—LIGHTING
- F21Y—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES F21K, F21L, F21S and F21V, RELATING TO THE FORM OR THE KIND OF THE LIGHT SOURCES OR OF THE COLOUR OF THE LIGHT EMITTED
- F21Y2115/00—Light-generating elements of semiconductor light sources
- F21Y2115/10—Light-emitting diodes [LED]
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- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
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- H01L33/00—Semiconductor devices with at least one potential-jump barrier or surface barrier specially adapted for light emission; Processes or apparatus specially adapted for the manufacture or treatment thereof or of parts thereof; Details thereof
- H01L33/48—Semiconductor devices with at least one potential-jump barrier or surface barrier specially adapted for light emission; Processes or apparatus specially adapted for the manufacture or treatment thereof or of parts thereof; Details thereof characterised by the semiconductor body packages
- H01L33/64—Heat extraction or cooling elements
- H01L33/645—Heat extraction or cooling elements the elements being electrically controlled, e.g. Peltier elements
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- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01L—SEMICONDUCTOR DEVICES NOT COVERED BY CLASS H10
- H01L33/00—Semiconductor devices with at least one potential-jump barrier or surface barrier specially adapted for light emission; Processes or apparatus specially adapted for the manufacture or treatment thereof or of parts thereof; Details thereof
- H01L33/48—Semiconductor devices with at least one potential-jump barrier or surface barrier specially adapted for light emission; Processes or apparatus specially adapted for the manufacture or treatment thereof or of parts thereof; Details thereof characterised by the semiconductor body packages
- H01L33/64—Heat extraction or cooling elements
- H01L33/648—Heat extraction or cooling elements the elements comprising fluids, e.g. heat-pipes
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Abstract
A method and apparatus for improving the cosmetic appearance of a region of skin (11) affected by Acne Vulgaris, Rosacea or similar skin condition by means of directing light radiation (12) from an illuminating device (1) on to the skin (11). The apparatus (10) comprises a control unit (9) that operates one or more LEDs (7) (light emitting diodes) of the illuminating device (1). Each dose of light radiation (12) lasts for at least 100ms, during which time the skin 11 receives light energy from the LED(s) (7), which causes a photochemical reaction that stimulates the production of free radicals (singlet oxygen) that react with, and at least partially disable or destroy, bacteria that contribute to the symptoms of the skin condition. The light energy directed on to the skin (11) during any given period of 10 s is less than 0.5 Jcm <2>,< >and during any given period of 100ms is less than 5 Jcm<-2>. Substantially no beneficial photo-thermal reaction occurs within the skin (11). Light having wavelengths around 405nm and/or 585nm is used. The duration of a single dose may be much longer than 100ms and can last up to 10 hours (for overnight treatment).
Description
Technical field
The present invention relates to a kind of instrument and method of improving skin or improving the beautifying skin effect.Particularly, the present invention relates to a kind of instrument and method of improving acne.
Background technology
The almost all people can be subjected to the influence of acne in certain stage in life.It is a kind of lipid folliculus (hole) situation and the damage that can cause skin, mainly occurs in face, shoulder and back.The symptom of acne and other similar skin problem from the beauty treatment angle, all is difficult to see, and makes us uncomfortable.
Acne is caused by series of factors, wherein being considered to most important factor has: hormone secretion excessive (especially androgen), (sebum is the oily matter that the lipid gland produces to produce excessive sebum, it can make the skin softness, smooth and waterproof), excessive dead cell comes off, and has antibacterial (especially Propionibacterium) and inflammatory reaction (chemotaxis) in the lipid folliculus.
This process occurs in dead Skin Cell and oils sebum material and blocks skin lipid together follicular the time.Dead skin and sebum form a kind of tamper, make oily matter and antibacterial be wrapped in the lipid folliculus.When skin continued normally to produce oily substance, the lipid folliculus just began to expand.Normal skin bacterium Propionibacterium is breeding fast in the hole of blocking.The material that bacterial reproduction produces causes the inflammation of folliculus and surrounding skin thereof.Health produces corresponding reaction, leukocyte is delivered to the position of inflammation.
Damage can be defined as according to the difference of the order of severity: blackhead, pimple, joint knot, pustule and cyst.Blackhead is the lipid folliculus that has blocked.Pimple is the less solid damage (less than 5mm) that protrudes in skin surface slightly.Bigger pimple is joint knot (greater than 5mm).Pustule is a domed shape, easily breaks, and main feature is to contain mixture such as leukocyte, dead cell and antibacterial.Cyst and pustule are similar but want big, are more serious inflammation and often cause cicatrix.
The prevention that various medicines improve for acne is that part is effective at least.In GB2 368 020, disclosed a kind of method of using light radiation to improve acne.In the embodiment that is disclosed, the specific energy density and the radiation of wavelength are provided, thereby can in skin, produce photochemistry and photochemical and thermal reaction.Photochemical reaction can hinder or eradicate the cause of disease of skin to a certain extent, and photochemical and thermal reaction increases the generation of collagen, reduces the danger that scabs.
The improvement method that shows in GB2 368 020 requires in the short period of time, and (10 μ s are to 100ms) provides higher relatively radiation dose (0.5Jcm
-2To 5Jcm
-2Thereby) in skin, produce photo-thermal effect.High like this energy is provided within a short period of time, requires to use high energy laser.These cost an arm and a leg for manufacturer and require the operator to be subjected to professional training, possess Professional knowledge, could use safely and effectively.
Summary of the invention
The purpose of this invention is to provide a kind of instrument that can improve skin matter, for example a kind of instrument that improves skin, and also relatively cheap and/or easy and simple to handle.Invention in addition or other purpose provide a kind of beauty method that improves the method for skin matter or be used to improve skin, relatively cheap and/or easy operating.
A part of the present invention provides a kind of instrument that improves skin, comprises:
Optical device; With
Be used for the control unit of operating optical equipment; Wherein
Adjust also and configure optical device, so that can be used for launching the light radiation of certain energy and wavelength, be enough to cause the photochemical reaction the skin zone in, this reaction can be so that the material of initiation skin inactivation or eliminated to a certain extent; With
Control unit and optical device; Described control unit and Guangxi's equipment are also adjusted and are configured, and make control unit can in use control the optical device light radiation and only occur in the zone of optical device 1000mm, like this:
In the time of 100ms at least, the light energy that receives in above-mentioned zone has 0.01Jcm at least
-2
In the specified 10 μ s of meaning in office, the light energy that receives in above-mentioned zone is less than 0.5Jcm
-2And in the specified 100ms of meaning in office, the light energy of transmission is less than 5Jcm
-2This sampling instrument just can be used for improving skin.
Another part of the present invention provides a kind of instrument that improves the beautifying skin effect, for example improves mammal people's skin beauty.Instrument comprises
Be used for launching the optical device of light radiation, and
Be used for controlling the control unit of optical instrument operation, wherein
Can set control unit by adjusting, make control unit can cause that optical device control light radiation only occurs in the zone of optical device 1000mm, like this:
In the time of 100ms at least, the light energy that receives in above-mentioned zone has 0.01Jcm at least
-2
In the specified 10 μ s of meaning in office, the light energy that receives in above-mentioned zone is less than 0.5Jcm
-2And
In the specified 100ms of meaning in office, the light energy of transmission is less than 5Jcm
-2Like this
Instrument just can be used to improve the cosmetic result of skin.Optical device will be adjusted setting, and when being used to control rayed skin, the light radiation that can launch certain energy and wave-length coverage is enough to cause the photochemical reaction in the target skin area like this.The photochemical reaction that causes like this can make those cause the material inactivation of infringement skin beauty effects or destroyed to a certain extent.
The present invention also further comprises provides a kind of instrument that is used for improving acne, comprises one or more light emitting diodes and a microprocessor, and described microprocessor is used for controlling the operation of above-mentioned one or more light emitting diodes; Above-mentioned microprocessor and light emitting diode are adjusted and configure, above-mentioned like this light emitting diode can be used to transmit the light radiation of doses to skin surface in the time of 100ms at least, like this, the above-mentioned dosage light energy that receives of skin surface 0.01Jcm at least
-2The optical wavelength of this transmission at 350nm between the 700nm, thus, instrument just can be used to improve the skin area that is influenced by acne, this improvement realizes in the following way: by producing photochemical reaction at the above-mentioned skin area position that is influenced by acne, excite the generation free radical, and this free radical can with the bacterial reaction that causes acne, at least to a certain extent can deactivation or destroy the antibacterial that these cause acne symptom.
According to the part that the invention described above is mentioned, will further introduce other alternative or more welcome feature of the present invention below.
Instrument can optionally or additionally be used to improve the cosmetic result on mammal skin surface, for example people.
The luminaire of instrument of the present invention can be adjusted and set, and makes equipment when being used to shine skin, can launch the light radiation of certain energy wave-length coverage and be enough to cause the photochemical reaction that the target skin area is interior.The photochemical reaction of Chan Shenging can make the material inactivation attractive in appearance of infringement on the skin or destroyed like this.
Luminaire preferably includes one or more light-emitting semiconductors.The form that this one or more light-emitting semiconductor equipment can be diode.This optical device may comprise for example one or more LEDs.LEDs compares with laser instrument, and its advantage is cheap, is convenient to operation.But laser diode also can be by additional or optionally use.Be very easily, this luminaire is a kind of equipment, for example comprises that at least one can be used as the semiconductor equipment of photoactivation radiated element, and the input power that requires single semiconductor equipment is less than 500W, preferably less than 100W.
Can make control unit can allow optical device in 200ms arrives the time of 3s by adjusting and set the control unit and the optical device of instrument, perhaps preferably can at 300ms in the time of 3s, transmit 0.01 to 100Jcm to above-mentioned zone
-2Luminous energy.Certainly, control unit and optical device can be adjusted and make launch light radiation in long improvement consuming time, in an improvement process, can transmit greater than 100Jcm in greater than 3 seconds time like this
-2The light of energy.The improvement that has possibly the persistent period reach 10 hours possibly, for example, some improvement is spent the night possibly.The control unit of preferred apparatus and luminaire can transmit less than 100Jcm in any 3 seconds time by adjusting and setting
-2Light energy.
Can make optical device in the improvement process, transmit pulsed-light radiation by adjusting and setting control unit and luminaire.Also can be selectively, control unit and luminaire are by adjusting and setting, and optical device transmits the continuous light radiation in the improvement process.Instrument can be set at and transmit successive radiation according to the needs of user, perhaps transmits the radiation of pulse.
Can make control unit can allow optical device in 100ms arrives the time of 100s by adjusting and set the control unit and the optical device of instrument, transmit 0.5 to 3Jcm to above-mentioned zone
-2Light energy.Can be by adjusting and set control unit and optical device, make the light radiation that control unit can allow optical device transmit single dose to skin area, described single dose light radiation 200ms in the time of 10s transmission (perhaps being preferably in 200ms in the time of 3s) and the light radiation of in the single dose light radiation, transmitting greater than 0.1Jcm
-2, and equal T
1* P
1, T wherein
1The time span of=single dose; P
1Be optical power density unit's (power of per unit area) and will satisfy 0.2Wcm
-2＜P1＜20Wcm
-2
Instrument can be a kind of form of fully loaded instrument also, makes it transmit the light energy of reduced levels.For example, by adjusting and set control unit and optical device, make control unit can allow optical device transmit the single dose light radiation to certain zone of skin, this single dose light radiation equals T in 300ms transmission (perhaps being preferably in 300ms in the time of 3s) and light radiation of transmitting in the time of 10s in the single dose light radiation
2* P
2, T wherein
2The time span of=single dose; P
2Be optical power density unit's (power of per unit area) and will satisfy 0.01Wcm
-2＜P2＜1Wcm
-2P2 also can satisfy 0.1Wcm
-2＜P2＜0.5Wcm
-2
Also can it be applicable to improving than the zonule relatively by adjusting and setting instrument.For example, instrument can be through adjusting and setting, 12 to 200mm
2The skin scope in carry out the single dose light radiation and improve.
Also can make it be applicable to long low-power operation by adjusting and setting instrument.For example, by adjusting and set control unit and optical device, make that control unit can be in continue 300ms to the 10 hour improvement process of (preferably can be controlled at 10 seconds to 8 hours ground scope in), transmit light radiation to skin area, the optical radiation energy that transmits in single improvement process is greater than 0.1Jcm
-2, and equal T
3* P
3, T wherein
3The time span that=single dose improves; P
3Be optical power density unit's (power of per unit area) and will satisfy 0.5mWcm
-2＜P3＜500mWcm
-2The improvement of longer time may continue at least 30 seconds, preferably continues at least 10 minutes, preferably continues at least 1 hour.
Also can it be applicable to relatively large zone is improved by adjusting and setting instrument.For example, instrument can be through adjusting and setting, at 0.003m
2To 0.5m
2The skin scope in carry out the single dose light radiation and improve.Preferred apparatus is through after adjusting, and the light radiation of transmitting in single improvement process equals T
3* P
3, T wherein
3The time span that=single dose improves; P
3Be optical power density unit's (power of per unit area) and will satisfy 0.5mWcm
-2＜P3＜500mWcm
-2
Preferably optical device is set for: the light radiation that comprises wavelength 350nm～1000nm scope is provided.Preferably set optical device and launch light radiation between the 1000nm, be preferably in 350nm between the 700nm with wavelength 350nm.The light radiation wavelength that optical device provides in radiative process can be set in 570nm between the 600nm, also can be optionally or adjust extraly optical device make its light radiation wavelength that provides at 390nm between the 420nm, preferably can comprise the light radiation wavelength of 405nm.
Use instrument to improve the photochemical reaction that skin produces and can occur in the porphyrin, porphyrin is the natural product of Propionibacterium.To further discuss below and the relevant method in another aspect of the present invention.The excitation spectrum of porphyrin all has the peak at 585nm and 405nm place.If the light radiation that improves include wavelength 390nm between the 420nm and 570nm to the light between the 600nm, the improvement advantage will be arranged very much, this combination can activate the porphyrin in the skin histology different depth.
And, it is generally acknowledged that HONGGUANG (wavelength at 630nm between the 680nm) helps the healing of wound.
Preferred optical device has highest energy less than 100Wcm through providing after adjusting
-2The light radiation of level, further preferred optical device has highest energy less than 10Wcm through providing after adjusting
-2The horizon light radiation.Preferably, optical device has highest energy less than 5Wcm through providing after adjusting
-2The horizon light radiation.Adjust optical device, make its highest energy level at 1Wcm
-2And 5Wcm
-2Between be favourable.The highest energy level also can be in 1Wcm
-2And 3Wcm
-2Between.
Instrument will comprise refrigerating plant, the temperature of control optical device.Control unit is set the operation of controlling this refrigerating plant by adjusting.Control unit includes suitable pre-programmed microprocessor easily.
According to the present invention, a kind of using method for above-mentioned instrument equally also is provided, be included in optical device is no more than the distance of 1000mm surface of light radiation irradiation with certain energy, like this, in the time of 100ms at least, have 12mm at least
2The zone can receive from what optical device sent and reach 0.01Jcm at least
-2Energy; Radiation comprise wave-length coverage 350nm to the radiation between the 700nm (preferably include contain 570m to 600nm and/or at 390nm to the radiation between the 420nm), in the time of the specified 10 μ s of meaning in office, the energy from optical device that above-mentioned zone receives is not less than 0.5Jcm
-2In the time of the specified 100ms of meaning in office, the energy from optical device that above-mentioned zone receives is not less than 5Jcm
-2Above-mentioned using method is used to improve the skin of application on human skin, has certain advantage, but is not necessary.For example, can use this instrument to provide a kind of method and/or a kind of beauty treatment of improving the beautifying skin effect to improve the method for skin matter.The human or animal's that this instrument can be used as at non-living body skin surface is tested or is demonstrated.
Instrument of the present invention can be adjusted easily, can use instrument directly to improve user skin, and need not carry out pre-cooling before improvement.
Invention the method for improving skin also is provided on the other hand, the step that comprises has:
Optical device is provided; With
Operating optical equipment makes light radiation arrive skin zone accordingly, improves; Wherein
Continue 100ms at least in once improving, will there be 0.01Jcm in described zone at least from the light energy that optical device receives
-2
In the specified 10 μ s of meaning in office, the light energy of transmission is lower than 0.5Jcm
-2
In the specified 100ms of meaning in office, the light energy of transmission is lower than 5Jcm
-2And,
Energy delivered causes photochemical reaction in the skin scope of being shone, described photochemical reaction at least can be so that cause the material inactivation of skin or destroyed.
According to invention on the other hand, equally also provide a kind of method that improves as the certain regional cosmetic result of mammal skin, the step that comprises has:
Optical device is provided; With
Operating optical equipment makes light radiation arrive skin zone accordingly, wherein
In 100ms at least, will there be 0.01Jcm in described zone at least from the light energy that optical device receives
-2
In the specified 10 μ s of meaning in office, the light energy of transmission is lower than 0.5Jcm
-2
In the specified 100ms of meaning in office, the light energy of transmission is lower than 5Jcm
-2
A kind of beauty treatment improvement method of acne equally also is provided, and the step that comprises has:
Optical device is provided; With
Operating optical equipment makes the skin respective regions that light radiation arrives to be influenced by acne, wherein,
Once improve and continue 100ms at least, described zone accepts to have 0.01Jcm at least from the light energy of optical device
-2
In the specified 10 μ s of meaning in office, the light energy of transmission is lower than 0.5Jcm
-2
In the specified 100ms of meaning in office, the light energy of transmission is lower than 5Jcm
-2And,
The photochemical reaction that energy delivered causes in the skin scope that is influenced at least can be so that cause the inactivation of bacteria of acne symptom or destroyed.
The present invention further provides a kind of method that improves skin matter, this method realizes through the following steps, provide optical device and operating optical equipment control light radiation to arrive certain zone of skin, in the time of 100ms at least, above-mentioned zone accepts to have 0.01Jcm at least from the light energy of optical device
-2The light energy of transmitting in the specified 10 μ s of meaning in office is lower than 0.5Jcm
-2, in the specified 100ms of meaning in office, the light energy of transmission is lower than 5Jcm
-2
According to invention on the other hand, also provide a kind of method of improving the skin acne here, said method comprising the steps of: one or more light emitting diodes are provided; Operate these one or more light emitting diodes and make light radiation arrive by the skin area of acne infection, wherein, in continuing the dosage of 100ms at least, above-mentioned zone has 0.01Jcm at least from the light energy that one or more light emitting diodes receive
-2, and light energy causes the photochemical reaction in the above-mentioned zone, excites the generation free radical, and free radical can with the bacterial reaction that produces acne symptom, make the antibacterial part inactivation that causes acne symptom or destroyed at least to a certain extent.
The light energy of Chuan Diing can produce photochemical reaction in skin like this.This method is can right and wrong curative.Specifically, operating optical equipment makes it produce the effect of non-therapeutic at skin area in one way.Adopt this method allow and improve the cosmetic result in infected skin zone.
By the direct sunshine radiation longer than the previous method time is provided, can transmit identical photon or energy density, but photon that is transmitted or energy density have lower power density or energy flux density, thereby have reduced the probability to skin generation such as light-mechanical effect (the exposure amplification of tissue) or light-heat effect (Fast Heating of tissue) side effect.In addition, provide the radiation of lower-wattage to mean that radiation not too can cause erythema (skin rubefaction).Usefully be to implement method of the present invention and need before being about to handle, not carry out any activation precooling process to skin.Some previous methods of using are used higher light intensity than the present invention, cause the target area to be heated rapidly, heat just can not scatter and disappear by blood system like this, so this quadrat method requires handling before skin to be cooled off, thereby avoids the ill effect for the generation of skin superheated.
Preferably in the time of above-mentioned 100ms at least, above-mentioned zone obtains to be less than 10Jcm from luminaire
-2Light energy, further preferably be lower than 1Jcm
-2Preferably in the time of above-mentioned 100ms at least, in 1 fen given arbitrarily clock time, be no more than 100Jcm
-2Light energy be transmitted.This method also can be in the time of above-mentioned 100ms at least, or in 10 fens given arbitrarily clock times, transmit and be no more than 100Jcm
-2Light energy.In time, the light energy of transmission is preferably lower than 1Jcm at given arbitrarily 1ms
-2In time, the light energy of transmission is preferably lower than 1Jcm at given arbitrarily 10ms
-2In the 500 given arbitrarily μ s times, the light energy of transmission is preferably lower than 1Jcm
-2Above-mentioned improvement process is preferably lower than 10 hours.
In the 10 given arbitrarily μ s times, the light energy of transmission is lower than 50mJcm
-2Better, be lower than 10mJcm
-2Better, be lower than 5mJcm
-2Best.In the 10 given arbitrarily μ s times, the light energy of transmission can be lower than 1mJcm
-2
Compared with former conventional method, the present invention requires lower power, and this just means that LEDs (light emitting diode) can be used for replacing laser.Under lower-wattage, the present invention compares more cheap with equal laser system, and complexity has also reduced.For the use of laser equipment, all there is quite strict regulation in many countries equally.Therefore this optical device includes many LEDs with having superiority, and for example, the many LEDs that comprise combine the formation array.Also can use independent LED.For example, LEDs can form a unidimensional linear array or a two-dimensional array is suitable for the larger area irradiation, as face or back.Conveniently be, LEDs flocks together and can form a face shield, allow user (people who for example, suffers from skin problem) be positioned at light shield below.Use such mask system, just can as 30 seconds time, make the radiation of same dose fully be applied to whole face at short notice.On the contrary, the operator uses the single-point application system to improve face and will take 30 minutes.In these two examples,, skin excites similar photochemical reaction thereby can receiving the same dose light radiation.
The method that this method can be used as non-therapeutic is used for human body.This method can be used as non-therapeutic, is not used for treating dermatosis, but is used for improving skin.This method can be used as a kind of form of beauty treatment improvement method.
The beauty treatment that this method is suitable for acne improves.This method also can be used as a kind of form of rosacea beauty treatment improvement method.
Here " skin " refers to mammal, especially people's skin.This method is suitable for non-surgery operation.For example, optical device is adjusted and is set at and can't operates under higher-wattage, makes like this and experienced operators such as surgeon can't use it for operating theater instruments.The pulsed dye laser equipment that these features make it to use with tradition is compared, and has considerable advantage, makes it safety and easy operating and production more because optical device can be set.
Use this method can on skin, cause photochemical reaction, thus inactivation or destroy Propionibacterium completely or partially, and as mentioned above, this bacterium is one of reason that causes acne.Propionibacterium is an anaerobe, and the existence of oxygen is harmful to it.Photochemical reaction can temporarily reduce some symptoms of acne and can't forever eliminate the materials such as antibacterial that cause skin symptom.
Photochemical reaction also can be carried out in a certain material, because the radiation of this material absorbing particular range of wavelengths (reaction will reduce outside this wave-length coverage or disappear significantly).Preferred employed radiation wavelength can produce photochemical reaction in the material (for example chromophore) of skin surface or inside, thereby produces the free radical (as single oxygen-derived free radicals) of eliminating bacteria.The preferred porphyrin of targeting chromophore.Porphyrin is the natural product that Propionibacterium produces.Porphyrin can produce single oxygen-derived free radicals after by the optical excitation of 585nm wavelength (gold-tinted) and 405nm wavelength around (purple light/black light).Light under other wavelength can excite the generation of free radical equally.
Therefore, by the mode that excites porphyrin described above, just can make the inactivation of bacteria that causes acne or destroyed with a kind of painless, Noninvasive and effective and efficient manner.Method of the present invention can partly be eliminated the antibacterial that causes skin at least and not need to use the above-mentioned high-power laser of mentioning with more shortcoming.
The time of improving, or the light radiation time span that optical device provides can reach, and between 100ms to 30 minute, preferably between 200ms to 10 second, further between preferred 200ms to 3 second, optimum selection is between 300ms to 2 second.Length that continues or time can be optionally or surpass 500ms extraly.In an improvement process or can successive transmission light radiation in the above-mentioned time.Also can be chosen in an improvement process or carry out the light radiation transmission of pulsed in the above-mentioned time.
The time span of light radiation preferably can be higher than the thermal relaxation time of skin near zone blood capillary system.Like this at the photochemical and thermal reaction described in the GB2368020, because relatively low optical radiation energy is acted in hundreds and thousands of microsecond times (time scale identical with the blood capillary thermal relaxation time), just can not be very remarkable in above-mentioned method.
The energy density of the optical radiation of transmitting for example can be 0.01 to 100Jcm
-2Between, preferred 0.1 to 10Jcm
-2Between, further preferred 0.5 arrive 3Jcm
-2Between, optimum selection 1 to 3Jcm
-2Between.Energy density can be lower than 2Jcm
-2Lower energy density is more suitable for long improvement.
Main light radiation wavelength all is predefined.Radiation for example can comprise having 350nm to the wavelength between the 1500nm, and preferred 350nm is between the 1000nm.The preferred 350m of wavelength asks that to 700nm's further preferred 570nm is between the 600nm, and optimum selection 580nm is between the 590nm.Light radiation mainly concentrates on the radiation of yellow wavelengths (585nm).Radiation is also included within the radiation of 350nm to the 450nm wavelength, and preferred 390nm is to the radiation of 420nm.Light radiation mainly concentrates on the radiation of purple light/black light wavelength (405nm).According to the present invention, especially in the scope that relates to the acne improvement, the radiation of selection is consistent with photosensitizer, as the porphyrin in the skin histology.The porphyrin that the selection of light radiation wavelength also can be fit to act in each degree of depth skin layer is consistent, guarantees that so single oxygen-derived free radicals release action is in acne and not obvious its hetero-organization that influences.
Radiation meeting under the corresponding to one or more wavelength of one or more crests of use and porphyrin absorption curve has superiority especially.
Light radiation can arrive 12 to 200mm of influenced skin
2The inner region scope for example can reach diameter and be 4 to 16mm some size.Region area also can be less than 100mm
2Yet also can improve bigger zone, for example can improve 0.1m simultaneously
2Or 0.5m
2The area of size.
The preferred the highest optical power of light radiation that transmits is lower than 100Wcm
-2, further preferably be lower than 10Wcm
-2The suitableeest optics output of the light radiation that provides can be 1 to 5Wcm
-2Between.
The luminous energy that optical device transmits like this can cause the photochemical reaction in the influenced skin area, thereby stimulates the generation free radical to participate in reaction, makes to cause that the material of skin is at least by part inactivation or destruction.
Lower powered point or linear improve to handle can be used for the improvement of " filling it up with " above-mentioned more high dose of mentioning and handle.For example, filling it up with improvement can provide than high dose and improve lower power and longer improvement time (as spending the night).So the low-power improvement is particularly suitable for using in the family this optical device.
During the improvement of this method is handled, suitablely make optical device and will transmit distance between the radiating surface less than 1000mm, preferably less than 100mm, also can be less than 50mm.Optical device and surface can be directly close to each other, for example can contact with each other when transmitting radiation.
More than set forth and in skin, caused photochemically reactive light energy.In order to cause the photochemical reaction in the skin, it is generally acknowledged that photochemically reactive scope/quantity mainly depends on the amount of the light that receives on the unit are (number of photons just), and the luminous power of using has less effect.According to some specific embodiment of the present invention, preferably in the relatively long time, transmit light energy.Some other specific embodiment in according to the present invention causes that skin is overheated and causes under the situation of certain power level of bad influence that it is more suitable to transmit light energy in the relatively short time not exceeding.So according to certain aspects of the invention, preferably can under the situation that does not exceed peak power output, use higher output.In case surpassing peak power output will be dangerous, causes ill effect.The place that the present invention has superiority especially has been to provide the instrument of the optical semiconductor transmitter (as LEDs or laser diode) that a kind of use can work under low-power.
What have very much value is, has comprised the using method of instrument among the present invention in the method for the present invention and instrument adjustment of the present invention is set to carrying out the present invention.Therefore, relevant with method of the present invention characteristics should be described on the instrument and equipment of the present invention.Simultaneously, the description to instrument feature of the present invention also should comprise in the method for the invention.
Description of drawings
Particular content of the present invention will be described for example with reference to following sketch map:
Fig. 1 represents to be used for to improve the instrument of being made up of control unit and optical device of user skin;
Control unit in Fig. 2 presentation graphs 1 and optical device;
Fig. 3 is the optical device more detailed description to instrument among Fig. 1.
The specific embodiment
Fig. 1 show by emission light radiation 12 to user skin 11, improve the instrument 10 of the skin problem that causes such as acne.The skin that will improve in the present embodiment is that diameter is the facial skin zone of the some area of 6mm.Instrument 10 in the present embodiment is manual battery powered parts, comprises optical device 1 and a control unit 9, and control appliance 1 emitted radiation is connected to each other.The shell of instrument 10 is extending in shape, by launching bright dipping near a terminal position optical device 1.The entire length of this shell is about 15cm.
The radiation that skin 11 is subjected to makes the porphyrin generation photochemical reaction in the skin, discharges single oxygen-derived free radicals (free radical a kind of) and can eliminate the antibacterial that some cause acne symptom at least.Yet the radiation dose of acceptance will be lower than the level that may cause erythema.Contain the light wave intensity peak at the light of 585nm wavelength and contain the light radiation of wave-length coverage in 570-600nm by the optical device radiation emitted.Such wavelength is fit to act on the porphyrin in the different cortex degree of depth, is enough to cause that discharging activation oxygen acts on Propionibacterium, and its hetero-organization of not appreciable impact.
Optical device comprises that a plurality of LEDs 7 arrange (having illustrated LEDs to arrange with a kind of tight compression form among Fig. 2) with two-dimensional array 2, is connected with one group of lens (not signal) then, makes the LEDs radiation emitted focus on, and so just can provide accumulative light source.Therefore equipment 1 be fit to skin " point improves " (for example: improve less zone one by one).Fig. 3 shows is that other of optical device 1 formed, and these compositions are used for cooling LED s.
Shown the composition of optical device (referring generally to be decided to be 1) among Fig. 3, be followed successively by in order: a LED diode array 2, high heat conducting hot spread layer 3, amber ear card type thermoelectric (al) cooler 4 and a hot channel arranged for 5 (comprising a tip condenser 6).
Mediation by the heat conducting spread layer 3 of height is diffused into bigger zone from the heat of LED diode array 2.The notable attribute of this one deck is that several micron thickness are only arranged, and heat is spread out of from diode array 2 rapidly and efficiently.Heat flows into the refrigeration end of amber ear card type thermoelectric (al) cooler 4 subsequently.The heating end of amber ear card type thermoelectric (al) cooler 4 is arranged in the thermoconverter that connects hot channel 5.High heat conduction layer 3 contains diamond materials, and it is to lay by a kind of method of ion/chemical vapour desposition.
Amber ear card type cooler 4 contains dispersive control element, and described control element contains the driver circuit that is associated, and in use, can accurately control heat and be diverted from LED diode array 2 by high conduction of heat spread layer 3.Accurately control drives amber ear card type thermoelectric (al) cooler 4 (arranging 5 combined with high conduction of heat spread layer 3 and the condensation of downstream heat pipeline) and makes instrument have thermal management quite efficiently, and especially diode array 2, and it can guarantee the continuity of light output.
Hot channel is arranged 5 and is contained the wick material, makes liquid condensing agent (be arranged in hot channel and arrange 5) by capillarity, gravity or diffusion, leave " thermal region ".Arrange packets contains mobile blood circulation, can be so that refrigerative liquid state circulate away from instrument tip " cool region ", and this is provided by condenser 6.Condenser 6 itself is lowered the temperature by air cooling.
Use this method improve acne/will in the facial acne person, test.The optical device that uses in test is a kind of point optical device (as mentioned above).In test, the single dose radiation emitted reaches 1.5J/cm in the some position of 6mm
-2Equally also designed be similar to narrate above but what be to use is that the instrument of big two-dimensional array is tested.The instrument of this array is suitable for shining and improving bigger zone, for example face and back.The result of preliminary test has confirmed to have good result for the improvement of skin.
Described the other instrument that is used for said method in WO 03/081127, main contents are only for reference here.
Under the prerequisite that does not break away from aim of the present invention, can carry out various adjustment to the specific embodiment of the invention described above.For example, optical device can become and anyly can allow optical device produce controllable radiation dose with suitable energy level and wavelength but be no more than other forms of certain power level.For example, optical device also can become a series of aforesaid optical devices (" linear improve ") or equipment is become the form of two-dimensional array, just as employed in the test (" improvement of big zone ").Also can be an improvement or the linear more equipment of small throughput that provides that improves, thus can be as " filling it up with " the above-mentioned more some improvement of high dose.This small throughput equipment will be particularly suitable for family and use.
In above-mentioned specific descriptions, employed radiating wavelength is in the scope of 570-600nm.But other embodiment can be envisioned as other porphyrin absworption peak that acts in the skin histology.Therefore, for example contain wavelength and also can use, can be used singly or in combination in the light radiation of purple/black light, blue light, green glow and red light wavelength band.Light can be from single instrument (may from an optical device), also can be by a plurality of instruments emissions that separate.Obviously, the control unit versicolor light that must be able to the control level relatively reaction light that transmits varying number arrives the different depth of skin---and the formulation that therefore improves scheme will depend on the degree of depth that Propionibacterium infects and decide.
Claims (17)
1. one kind is used for improving looks and improves the instrument of skin, comprises
Optical device and
Be used for controlling the control unit of optical device; It is characterized in that:
Adjusting and set optical device makes it can be used for launching the light radiation of certain energy and wave-length coverage, be enough to cause the photochemical reaction in the skin area that is infected by skin, the material that described photochemical reaction will cause causing skin is inactivation or destroyed at least to a certain extent, and optical device is by adjusting and setting, in use, there is not useful photochemical and thermal reaction in above-mentioned skin area, to take place in essence, simultaneously
Control unit and optical device are adjusted and set, and make control unit can allow optical device launch light radiation in the distance that is no more than apart from optical device 1000mm, like this:
In the time of 100ms at least, the light energy that receives in the above-mentioned zone has 0.01Jcm at least
-2
In the specified 10 μ s of meaning in office, the light energy that receives in the above-mentioned zone is lower than 0.5Jcm
-2
And in the specified 100ms of meaning in office, the light energy of transmission is lower than 5Jcm
-2Like this
Instrument just can be used for improving skin.
2. instrument as claimed in claim 1 is characterized in that: described skin is an acne.
3. instrument as claimed in claim 1 or 2, it is characterized in that: by adjusting and set control unit and optical device, make control unit can be used for causing that optical device transmits the light radiation of single dose to certain zone of skin, this single dose light radiation transmits in the time of 10s at 200ms, and the optical radiation energy that transmits in the single dose light radiation is greater than 0.1Jcm
-2, equal T
1* P
1, T wherein
1The time span of=single dose; P
1Be optical power density unit's (power of per unit area) and satisfy 0.2Wcm
-2＜P
1＜20Wcm
-2
4. instrument as claimed in claim 1 or 2, it is characterized in that: by adjusting and set control unit and optical device, make control unit can be used for causing that optical device transmits certain zone of light radiation arrival skin of single dose, this single dose light radiation is transmitted in the time of 10s at 200ms, and the optical radiation energy that transmits in the single dose light radiation equals T
2* P
2, T wherein
2The time span of=single dose; P
2Be optical power density unit's (power of per unit area) and satisfy 0.01Wcm
-2＜P2＜1Wcm
-2
5. as claim 3 or 4 described instruments, it is characterized in that:, make in the light radiation process of single dose that can improve area is 12 to 200mm by adjusting and setting instrument
2Skin area.
6. instrument as claimed in claim 1 or 2, it is characterized in that: by adjusting and set control unit and optical device, control unit can transmit light radiation to skin area in the single that continues 300ms to 10 hour improves, the optical radiation energy that transmits in single improvement process is greater than 0.1Jcm
-2, equal T
3* P
3, T wherein
3The time span that=single improves; P3 is optical power density unit's (power of per unit area), and satisfies 0.5mWcm
-2＜P3＜500mWcm
-2
7. instrument as claimed in claim 6 is characterized in that:, make in single improves that can improve area is 0.003 to 0.5m by adjusting and setting instrument
2Skin area.
8. as the described instrument of above-mentioned any one claim, it is characterized in that: comprise that by setting optical device, can providing 570nm is to the interior light radiation of 600nm wave-length coverage.
9. as the described instrument of above-mentioned any one claim, it is characterized in that: comprise that by setting optical device, can providing 390nm is to the interior light radiation of 420nm wave-length coverage.
10. as the described instrument of above-mentioned any one claim, it is characterized in that: optical device comprises one or more emitting semiconductor equipment.
11. instrument as claimed in claim 10 is characterized in that: each semiconductor device all is the diode form.
12. as the using method of the described instrument of above-mentioned any one claim, it is characterized in that: described method is included in to be no more than in the 1000mm apart from optical device carries out light radiation with certain energy to certain surface, in the time of 100ms at least, at least 12mm can be arranged like this
2The zone can receive the 0.01Jcm at least that sends from optical device
-2Energy, radiation comprise wave-length coverage at 570nm to the radiation between the 600nm, in the time of the specified 10 μ s of meaning in office, the energy from optical device that described zone receives is lower than 0.5Jcm
-2In the time of the specified 100ms of meaning in office, the energy from optical device that described zone receives is lower than 5Jcm
-2
13. a method that improves skin beauty is characterized in that: described method comprises carries out following non-therapeutic step:
Provide optical device and
Operating optical equipment control light radiation arrives certain zone of skin, wherein
In the time of 100ms at least, above-mentioned zone accepts to have 0.01Jcm at least from the light energy of optical device
-2
In the specified 10 μ s of meaning in office, the light energy of Chuan Diing is lower than 0.5Jcm like this
-2
In the specified 100ms of meaning in office, the light energy of Chuan Diing is lower than 5Jcm like this
-2Wherein, energy delivered causes photochemical reaction in the skin that is influenced by skin, and this reaction at least can be so that cause the antibacterial part inactivation of skin symptom or destroyed; Wherein, the light energy of being transmitted does not cause that in essence useful photochemical and thermal reaction takes place in above-mentioned skin area.
14. method as claimed in claim 13, it is characterized in that: above-mentioned light radiation arrives the skin area that is influenced by acne, the light energy of transmitting causes photochemical reaction in affected skin, described photochemical reaction at least can be so that cause the antibacterial part inactivation of acne symptom or destroyed.
15. as claim 13 or 14 described methods, it is characterized in that: photochemical reaction excites the generation of free radical, described free radical and the substance reaction that causes skin at least can be so that these material part inactivations or destroyed.
16., it is characterized in that:, make it can be applicable to any one described method in the claim 13 to 15 by adjusting and setting instrument as any one described instrument in the claim 1 to 12.
17. the instrument described in any width of cloth accompanying drawing.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0301740.7 | 2003-01-24 | ||
| GBGB0301737.3A GB0301737D0 (en) | 2003-01-24 | 2003-01-24 | Method and device for treatment of skin conditions |
| GB0301737.3 | 2003-01-24 | ||
| GB0301740A GB2397528B (en) | 2003-01-24 | 2003-01-24 | Method and device for treatment of skin conditions |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1756577A true CN1756577A (en) | 2006-04-05 |
Family
ID=32773978
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNA2004800056603A Pending CN1756577A (en) | 2003-01-24 | 2004-01-23 | Apparatus and method for treatment of skin conditions |
Country Status (7)
| Country | Link |
|---|---|
| EP (1) | EP1587583A1 (en) |
| JP (1) | JP2006515772A (en) |
| KR (1) | KR20050096139A (en) |
| CN (1) | CN1756577A (en) |
| CA (1) | CA2514213A1 (en) |
| GB (2) | GB2397528B (en) |
| WO (1) | WO2004064923A1 (en) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102563384A (en) * | 2010-12-14 | 2012-07-11 | 上海广茂达光艺科技股份有限公司 | Lighting device with sterilizing function |
| CN101641133B (en) * | 2007-03-30 | 2013-03-06 | 松下电器产业株式会社 | Hair growth control method and apparatus for the method |
| CN101609358B (en) * | 2008-06-17 | 2014-02-12 | 联想(北京)有限公司 | Radiating module, fan and computer |
| CN104136075A (en) * | 2012-02-21 | 2014-11-05 | 本加恩·阿萨哈 | A hand-held device for combined light and electrotherapy of a skin surface |
| CN109529200A (en) * | 2018-10-30 | 2019-03-29 | 杨原茂 | A kind of photon therapeutic equipment and its application method |
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| US6517532B1 (en) | 1997-05-15 | 2003-02-11 | Palomar Medical Technologies, Inc. | Light energy delivery head |
| US8182473B2 (en) | 1999-01-08 | 2012-05-22 | Palomar Medical Technologies | Cooling system for a photocosmetic device |
| US6273884B1 (en) | 1997-05-15 | 2001-08-14 | Palomar Medical Technologies, Inc. | Method and apparatus for dermatology treatment |
| AU3450799A (en) | 1998-03-12 | 1999-09-27 | Palomar Medical Technologies, Inc. | System for electromagnetic radiation of the skin |
| KR20050026404A (en) | 2002-06-19 | 2005-03-15 | 팔로마 메디칼 테크놀로지스, 인코포레이티드 | Method and apparatus for photothermal treatment of tissue at depth |
| EP2522294A2 (en) | 2002-10-23 | 2012-11-14 | Palomar Medical Technologies, Inc. | Phototreatment device for use with coolants and topical substances |
| US7856985B2 (en) | 2005-04-22 | 2010-12-28 | Cynosure, Inc. | Method of treatment body tissue using a non-uniform laser beam |
| WO2006125231A2 (en) * | 2005-05-17 | 2006-11-23 | Photon Therapy Systems (Proprietary) Limited | A photon therapy device |
| CA2622560A1 (en) | 2005-09-15 | 2007-03-29 | Palomar Medical Technologies, Inc. | Skin optical characterization device |
| JP2007151807A (en) * | 2005-12-05 | 2007-06-21 | Univ Meijo | Phototherapy method by semiconductor light-emitting element, and phototherapy system by semiconductor light-emitting element |
| US7586957B2 (en) | 2006-08-02 | 2009-09-08 | Cynosure, Inc | Picosecond laser apparatus and methods for its operation and use |
| KR100842040B1 (en) * | 2007-07-26 | 2008-06-30 | (주)디오시스엠엔엠 | An apparatus for treating skin |
| US9919168B2 (en) | 2009-07-23 | 2018-03-20 | Palomar Medical Technologies, Inc. | Method for improvement of cellulite appearance |
| KR101135140B1 (en) * | 2011-04-07 | 2012-04-16 | 강원대학교산학협력단 | A portable device for treatment of pimple using light |
| KR102183581B1 (en) | 2012-04-18 | 2020-11-27 | 싸이노슈어, 엘엘씨 | Picosecond laser apparatus and methods for treating target tissues with same |
| EP2973894A2 (en) | 2013-03-15 | 2016-01-20 | Cynosure, Inc. | Picosecond optical radiation systems and methods of use |
| JP6200267B2 (en) * | 2013-10-07 | 2017-09-20 | カイゲンファーマ株式会社 | 5α reductase inhibitor |
| CA3092248A1 (en) | 2018-02-26 | 2019-08-29 | Mirko Mirkov | Q-switched cavity dumped sub-nanosecond laser |
| EP3603745B1 (en) | 2018-07-30 | 2021-12-22 | bredent medical GmbH & Co. KG | Therapy device for irradiating a surface of a tissue |
| US20200054893A1 (en) * | 2018-08-14 | 2020-02-20 | Seoul Viosys Co., Ltd. | Light irradiation apparatus |
| WO2021151518A1 (en) | 2020-01-31 | 2021-08-05 | Bredent Medical Gmbh & Co. Kg | Therapy device for irradiating a surface of tissue |
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| US5549660A (en) * | 1990-11-15 | 1996-08-27 | Amron, Ltd. | Method of treating acne |
| US5643334A (en) * | 1995-02-07 | 1997-07-01 | Esc Medical Systems Ltd. | Method and apparatus for the diagnostic and composite pulsed heating and photodynamic therapy treatment |
| DE69940738D1 (en) * | 1998-07-09 | 2009-05-28 | Curelight Medical Ltd | DEVICE AND METHOD FOR EFFICIENT HIGHERGETIC PHOTODYNAMIC THERAPY OF ACNE VULGARIS AND SEBORRHOE |
| US6663659B2 (en) * | 2000-01-13 | 2003-12-16 | Mcdaniel David H. | Method and apparatus for the photomodulation of living cells |
| GB2356570A (en) * | 1999-09-30 | 2001-05-30 | Oe Lys Ltd | Acne treating apparatus based on the emission of light in three different ranges of wavelength |
| GB2368020A (en) * | 2000-10-18 | 2002-04-24 | Icn Photonics Ltd | Treatment of acne vulgaris skin condition by irradiation with light of specific wavelengths to target specific chromophores & stimulate collagen production |
| DE10123926A1 (en) * | 2001-03-08 | 2002-09-19 | Optomed Optomedical Systems Gmbh | irradiation device |
-
2003
- 2003-01-24 GB GB0301740A patent/GB2397528B/en not_active Expired - Fee Related
- 2003-01-24 GB GBGB0301737.3A patent/GB0301737D0/en not_active Ceased
-
2004
- 2004-01-23 CA CA002514213A patent/CA2514213A1/en not_active Abandoned
- 2004-01-23 CN CNA2004800056603A patent/CN1756577A/en active Pending
- 2004-01-23 KR KR1020057013260A patent/KR20050096139A/en not_active Application Discontinuation
- 2004-01-23 JP JP2006500241A patent/JP2006515772A/en not_active Withdrawn
- 2004-01-23 EP EP04704641A patent/EP1587583A1/en not_active Ceased
- 2004-01-23 WO PCT/GB2004/000285 patent/WO2004064923A1/en not_active Application Discontinuation
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101641133B (en) * | 2007-03-30 | 2013-03-06 | 松下电器产业株式会社 | Hair growth control method and apparatus for the method |
| CN101609358B (en) * | 2008-06-17 | 2014-02-12 | 联想(北京)有限公司 | Radiating module, fan and computer |
| CN102563384A (en) * | 2010-12-14 | 2012-07-11 | 上海广茂达光艺科技股份有限公司 | Lighting device with sterilizing function |
| CN104136075A (en) * | 2012-02-21 | 2014-11-05 | 本加恩·阿萨哈 | A hand-held device for combined light and electrotherapy of a skin surface |
| US9962545B2 (en) | 2012-02-21 | 2018-05-08 | Unimed Aps | Hand-held device for combined light and electrotherapy of a skin surface |
| CN109529200A (en) * | 2018-10-30 | 2019-03-29 | 杨原茂 | A kind of photon therapeutic equipment and its application method |
Also Published As
| Publication number | Publication date |
|---|---|
| CA2514213A1 (en) | 2004-08-05 |
| GB2397528A (en) | 2004-07-28 |
| WO2004064923A1 (en) | 2004-08-05 |
| KR20050096139A (en) | 2005-10-05 |
| GB2397528B (en) | 2005-07-13 |
| JP2006515772A (en) | 2006-06-08 |
| GB0301737D0 (en) | 2003-02-26 |
| EP1587583A1 (en) | 2005-10-26 |
| GB0301740D0 (en) | 2003-02-26 |
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