CN1548038A - New acetaminophen prepn - Google Patents
New acetaminophen prepn Download PDFInfo
- Publication number
- CN1548038A CN1548038A CNA031266401A CN03126640A CN1548038A CN 1548038 A CN1548038 A CN 1548038A CN A031266401 A CNA031266401 A CN A031266401A CN 03126640 A CN03126640 A CN 03126640A CN 1548038 A CN1548038 A CN 1548038A
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- CN
- China
- Prior art keywords
- acetaminophen
- preparation
- contain
- injectable powder
- props
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
The present invention relates to the new preparation of acetaminophen, and the new preparation is powder for injection containing acetaminophen in 50 mg to 10 g each and freeze dried powder for injection. The new preparation is suitable for treating fever caused by common cold or flu and may be also used in treating various pain, such as arthralgia, migraine, headache, etc.
Description
● invention field
The present invention is the new preparation way of acetaminophen.Said preparation is to contain injectable powder and the lyophilized injectable powder that acetyl aminophenol 50mg-10g/ props up.Said preparation is applicable to and is used for the heating that common cold or influenza cause clinically, also is used to alleviate light moderate pain such as arthralgia, migraine, headache, myalgia, toothache, dysmenorrhea, neuralgia etc.
● background technology
Acetaminophen (Acetaminophen, Paracetamol, acetaminophen) as bringing down a fever and analgesic, be used for the heating that a variety of causes causes clinically, with various slight～non-inflammatory pain of moderate, comprise headache, arthralgia, neuralgia, dysmenorrhea, operation pain, treatment of traumatic pain etc.For the patient who is unsuitable for aspirin, this product is particularly suitable.
Acetaminophen adult maximal dose every day is no more than 4g.By recommended dose, acetaminophen is a safety, the less antipyretic analgesic of side effect, anaphylaxiss such as accidental erythra, drug fever, slight bronchospasm.
The acetaminophen convas tablet has been developed paracetamol injection determined and Aminodyne Compound injection in recent years.But in actual use, because acetaminophen is easy to hydrolysis, the following period of time injection after production color can occur and redden, and product is rotten.
Be to improve the problem of acetaminophen hydrolysis in solution, we have developed acetaminophen injectable powder and lyophilized injectable powder, and these two dosage forms have solved the hydrolysis problem that acetaminophen is in solution state for a long time.Acetaminophen injectable powder and lyophilized injectable powder exist with pulverulence in production and storage and transport process, with the salt water dissolution, have improved product stability before use, have also prolonged the shelf-life.
● summary of the invention
The present invention is the new preparation way of acetaminophen, and said preparation is to contain injectable powder and the lyophilized injectable powder that acetaminophen 50mg-10g/ props up.Said preparation has solved acetaminophen hydrolysis problem under solution state, has improved stability of formulation and has prolonged the shelf-life.
● embodiment
Example one: acetaminophen injectable powder preparation
The acetaminophen raw material, aseptic process is pressed the operation of powder pin process, the preparation injectable powder.
Example two: acetaminophen injectable powder preparation
The acetaminophen raw material, aseptic process is pressed the operation of freeze-dried powder process, the preparation lyophilized injectable powder.
Claims (5)
1, the new preparation way of acetaminophen, said preparation are applicable to and are used for the heating that common cold or influenza cause clinically, also be used to alleviate light moderate pain such as arthralgia, migraine, headache, myalgia, toothache, dysmenorrhea, neuralgia etc.
2,, it is characterized in that said preparation is to contain the injectable powder that acetaminophen 50mg-10g/ props up according to the preparation of claim 1.
3,, it is characterized in that said preparation is to contain the lyophilized injectable powder that acetaminophen 50mg-10g/ props up according to the preparation of claim 1.
4, according to the preparation of claim 2, it is characterized in that said preparation contain one or more adjuvant or and the drug regimen of excipient, wherein contain the injectable powder that acetaminophen 50mg-10g/ props up.
5, according to the preparation of claim 3, it is characterized in that said preparation contain one or more adjuvant or and the drug regimen of excipient, wherein contain the lyophilized injectable powder that acetaminophen 50mg-10g/ props up.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA031266401A CN1548038A (en) | 2003-05-22 | 2003-05-22 | New acetaminophen prepn |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA031266401A CN1548038A (en) | 2003-05-22 | 2003-05-22 | New acetaminophen prepn |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1548038A true CN1548038A (en) | 2004-11-24 |
Family
ID=34321952
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNA031266401A Pending CN1548038A (en) | 2003-05-22 | 2003-05-22 | New acetaminophen prepn |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1548038A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102258485A (en) * | 2011-01-11 | 2011-11-30 | 北京润德康医药技术有限公司 | Acetaminophen-contained preparation for injection and applications thereof |
| CN103083253A (en) * | 2011-11-07 | 2013-05-08 | 杭州赛利药物研究所有限公司 | Lyophilized preparation of acetaminophen and preparation method thereof |
| CN103083253B (en) * | 2011-11-07 | 2016-12-14 | 杭州赛利药物研究所有限公司 | Acetaminophen lyophilized formulations and preparation method thereof |
-
2003
- 2003-05-22 CN CNA031266401A patent/CN1548038A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102258485A (en) * | 2011-01-11 | 2011-11-30 | 北京润德康医药技术有限公司 | Acetaminophen-contained preparation for injection and applications thereof |
| CN103083253A (en) * | 2011-11-07 | 2013-05-08 | 杭州赛利药物研究所有限公司 | Lyophilized preparation of acetaminophen and preparation method thereof |
| CN103083253B (en) * | 2011-11-07 | 2016-12-14 | 杭州赛利药物研究所有限公司 | Acetaminophen lyophilized formulations and preparation method thereof |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |