CN1424051A - Lyophilized scorpion venoms powder injection - Google Patents
Lyophilized scorpion venoms powder injection Download PDFInfo
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- CN1424051A CN1424051A CN02139564A CN02139564A CN1424051A CN 1424051 A CN1424051 A CN 1424051A CN 02139564 A CN02139564 A CN 02139564A CN 02139564 A CN02139564 A CN 02139564A CN 1424051 A CN1424051 A CN 1424051A
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- China
- Prior art keywords
- scorpion venom
- powder
- lyophilized injectable
- hour
- lyophilized
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Abstract
A freeze dried powder injection of scorpion venom for treating rheumatism, rheumatalgia and tumor is prepared from scorpion venom powder, supporting agent of freeze dried powder and osmotic pressure regulator through freeze drying. Its advantages are high stability and durability, and less pollution.
Description
Technical field:
The present invention relates to a kind of drug for injection scorpion venom lyophilized injectable powder, also relate to the preparation method of this injectable powder simultaneously.
Background technology:
Rheumatism, pain, tumor are the diseases that is detrimental to health, and the scorpion venom lyophilized injectable powder can be used for above-mentioned treatment of diseases.Present similar this product preparation is an aqueous injection, and freeze cold season easily, and need preserve hot season 2-8 ℃ of condition, and in use have inconvenience more: 1. preparation very easily infects thermal source and polluted bacteria; 2. in cold and hot season, all there are inconvenience in transportation and storage; 3. liquid preparation breakage very easily causes cross-contamination to packing and inner packing; 4. the peptide material in the scorpion venom powder is degraded and inactivation in aqueous solution easily.
Summary of the invention:
The object of the present invention is to provide a kind of to stable performances such as light, heat, oxygen, water, pollution-free, and be convenient to the operation, the transportation and the storage, be applicable to large-scale production scorpion venom lyophilized injectable powder.Another object of the present invention provides the preparation method of this injectable powder.The object of the present invention is achieved like this: the present invention forms and comprises scorpion venom powder, lyophilized powder proppant and osmotic pressure regulator, and parts by weight are:
Scorpion venom powder 0.01----1 part
Frozen-dried supporting agent 0----90 part
Osmotic pressure regulator 0----15 part
The present invention is a lyophilized injectable powder, and pH value is between 5.5-7.5, and optimum pH is between 6.0-7.0.Its purposes widen for: be used in rheumatism, pain, tumor treatment of conditions, but the feeder vessels external administration.Wherein the lyophilized powder proppant is the water solublity proppant, and is soluble in water, and dissolving rapidly is selected from mannitol, albumin, glucose, dextran, gelatin hydrolysate etc. in clinical use; Osmotic pressure regulator specially refers to sodium chloride.The preparation method of scorpion venom lyophilized injectable powder provided by the invention is: get prescription scorpion venom powder and add the 0.9%NaCl stirring and dissolving, add frozen-dried supporting agent, aseptic filtration contains scorpion venom protein 20 μ g according to every, and the fill of volume 0.5ml amount is in the 2ml cillin bottle; Pre-freeze is to-45---35 ℃ of insulation 1-3 hour then, and the evacuation distillation in 15-20 hour, rises to temperature-15---2 ℃, in 2-5 hour, temperature is risen to 30---50 ℃ again, continues to keep vacuum 3--5 hour; Add plug under the vacuum, jewelling cap seal mouth.
The present invention is with the injectable sterile powder of lyophilization principle preparation compared with prior art, is lyophilized injectable powder, and pH is between 6.0-7.0.Have the following advantages: the cross-contamination issue that has 1. solved damaged back product; 2. reduced volume and weight, saved the cost of transportation of each process of operation, solved transportation and the storage problem of cold and hot season with the dosage medicine; 3. be convenient to operation, be applicable to large-scale production.4. the injectable powder water content is lower than 3% (W/W), the phenomenon of having avoided Buthotoxin polypeptide to degrade easily in aqueous solution.
The specific embodiment: be described in further detail the present invention below by embodiment.
Embodiment 1
(1) preparation prescription:
Scorpion venom powder 0.0275g
Mannitol 30g
Sodium chloride 3.15g
Prepare 1000
(2) preparation technology:
Get recipe quantity and contain the scorpion venom powder 27.5mg that the scorpion venom protein concentration is 0.75% (w/w), add the 50ml0.9%NaCl dissolving, the special-purpose membrane filtration of 0.22 μ m; Under aseptic condition, add injection 0.9%NaCl 300ml and 20% mannitol 150ml successively; Fully mix, then according to the amount fill of every 0.5ml in the cillin bottle of 2ml, every contains scorpion venom protein 20 μ g, the false add plug is placed on and carries out lyophilizing in the freezer dryer.Elder generation's pre-freeze is to-45---35 ℃ of insulation 1-3 hour, and the evacuation distillation in 15-20 hour, rises to temperature-15---2 ℃, in 2-5 hour, temperature is risen to 30--50 ℃ again, continues to keep vacuum 3--5 hour; Add plug under the vacuum, take out behind the inflated with nitrogen, jewelling cap seal mouth.Embodiment 2
(1) preparation prescription:
Scorpion venom powder 0.0275g
Albumin 10g
Sodium chloride 3.15g
Prepare 1000
(2) preparation technology:
Get recipe quantity and contain the scorpion venom powder 27.5mg that the scorpion venom protein concentration is 0.75% (w/w), add the 50ml0.9%NaCl dissolving, the special-purpose membrane filtration of 0.22 μ m; Under aseptic condition, add injection 0.9%NaCl 400ml and 20% albumin solution 50ml successively; Fully mix, then according to the amount fill of every 0.5ml in the cillin bottle of 2ml, every contains scorpion venom protein 20 μ g, the false add plug is placed on and carries out lyophilizing in the freezer dryer.Elder generation's pre-freeze is to-45---35 ℃ of insulation 1-3 hour, and the evacuation distillation in 15-20 hour, rises to temperature-15---2 ℃, in 2-5 hour, temperature is risen to 30--50 ℃ again, continues to keep vacuum 3--5 hour; Add plug under the vacuum, take out behind the inflated with nitrogen, jewelling cap seal mouth.
Claims (7)
1, a kind of injection scorpion venom lyophilized injectable powder, it is characterized in that: its composition comprises scorpion venom powder, lyophilized powder proppant and osmotic pressure regulator, parts by weight are:
Scorpion venom powder 0.01----1 part
Frozen-dried supporting agent 0----90 part
Osmotic pressure regulator 0----15 part
2, according to claims 1 described scorpion venom lyophilized injectable powder, it is characterized in that: this injection is a lyophilized injectable powder.
3, according to claims 1 described scorpion venom lyophilized injectable powder, it is characterized in that: this injection also is applicable to treatment of conditions such as rheumatism, analgesia, tumor, but the feeder vessels external administration.
4, according to the preparation method of claims 2 described scorpion venom lyophilized injectable powders, it is characterized in that: get prescription scorpion venom powder and add the 0.9%NaCl stirring, add frozen-dried supporting agent, aseptic filtration, contain scorpion venom protein 20 μ g according to every, the fill of volume 0.5ml amount is in the 2ml cillin bottle; Pre-freeze is to-45---35 ℃ of insulation 1-3 hour then, and evacuation in 15-20 hour, rises to temperature-15---2 ℃, in 2-5 hour, temperature is risen to 30--50 ℃ again, continues to keep vacuum 3--5 hour; Add plug under the vacuum, inflated with nitrogen takes out back jewelling cap seal mouth.
5, according to claim 1 or 4 described scorpion venom lyophilized injectable powder and preparation methoies, it is characterized in that: pH value is between 5.5-7.5.
6, according to claims 1 or 4 described scorpion venom lyophilized injectable powder and preparation methoies, it is characterized in that: described lyophilized powder proppant is the water solublity proppant, is selected from mannitol, albumin, glucose, dextran, gelatin hydrolysate etc.
7, according to claim 1 or 4 described scorpion venom lyophilized injectable powder and preparation methoies, it is characterized in that: osmotic pressure regulator specially refers to sodium chloride.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN02139564A CN1424051A (en) | 2002-11-29 | 2002-11-29 | Lyophilized scorpion venoms powder injection |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN02139564A CN1424051A (en) | 2002-11-29 | 2002-11-29 | Lyophilized scorpion venoms powder injection |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1424051A true CN1424051A (en) | 2003-06-18 |
Family
ID=4750144
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN02139564A Pending CN1424051A (en) | 2002-11-29 | 2002-11-29 | Lyophilized scorpion venoms powder injection |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1424051A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005004887A1 (en) * | 2003-07-08 | 2005-01-20 | Toximed Gmbh | Pharmaceutical agent against colon carcinoma and other tumor types |
| WO2005027942A1 (en) * | 2003-09-16 | 2005-03-31 | Toximed Gmbh | Pharmaceutical active ingredient made from snake poison to fight against melanomas |
-
2002
- 2002-11-29 CN CN02139564A patent/CN1424051A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005004887A1 (en) * | 2003-07-08 | 2005-01-20 | Toximed Gmbh | Pharmaceutical agent against colon carcinoma and other tumor types |
| WO2005027942A1 (en) * | 2003-09-16 | 2005-03-31 | Toximed Gmbh | Pharmaceutical active ingredient made from snake poison to fight against melanomas |
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| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |