CN1545936A - Edible combination containing active Lactobacillus paracasei and preparation method thereof - Google Patents
Edible combination containing active Lactobacillus paracasei and preparation method thereof Download PDFInfo
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Abstract
The invention relates to an edible composition, in particular an edible composition containing active bacterium and suitable for all people, and its preparing process which comprises, (1) bacterial strain screening, bacterium culturing, (3) viable bacteria powder preparation, (4) preparation of edible compositions.
Description
Technical field:
The present invention relates to a kind of edible composition, particularly a kind of edible composition that contains active probiotic, suitable all groups and preparation method thereof.
Background technology:
At present, the probiotic bacterium based food on the market is based on milk-product.From the whole world, sour milk still is the main form of probiotic bacterium series products, accounts for the 30-40% of probiotic bacterium functional foodstuff, contains the small bottle packing probiotic beverage of high density viable bacteria but wherein about 75% market is a class, and can sustainable growth.The product " Yakult, chlorella yakult " that first small bottle packing probiotic beverage is put on market in nineteen fifty-five for Japan, its physiologically active ingredient is mainly the lactobacterium casei viable bacteria.
Because the probiotic bacterium unique biological is active and the widespread use in milk-product, probiotic bacterium series products viable bacteria stability problem in processing, storage process more and more causes technological development, production, market development personnel and human consumer's concern.All there is the viable count standard of relevant probiotic products in many countries, as Japanese cultured milk prod and lactobacillus drink association (The Fermented Milks andLactic Acid Bacteria Beverages Association) regulation, the viable count in the fresh dairy product must reach 10 at least
7CFU/ml, probiotic bacterium content should be 10 at least
6The viable count that CFU/ml or every day are taken in is at least 10
8CFU (Robinson, R.K.Survival of Lactobacillusacidophilus in fermented products.Suid Afrikaanse Tydskrif VirSuiwelkunde, 1987,19 (1); 25-10727); Calendar year 2001, China Ministry of Health stipulated that viable bacteria class probiotic bacterium protective foods viable bacteria number in its preservation period must not be less than 10
6CFU/ml (g) (Mycophyta and probiotic bacterium class protective foods evaluation regulation are defended the method prison and sent out (2001) No. 84).However, the stability of keeping probiotic bacterium under the normal temperature is still an insoluble problem, and many probiotic bacterium milky-drinkss (as Yakult), probiotic bacterium capsule class medicine (as Birid Triple Viable etc.) all need refrigerate storage and transportation, the quality guaranteed period is short, cost is high.As seen, though some probiotic strain has the unique biological activity, usually because the restriction of production technology has hindered the application of these probiotic bacteriums.
Probiotic strain in the successful probiotic products mainly refers to Bacterium lacticum and bifidus bacillus, at first must screen from the human intestinal normal microflora, has unique intestinal epithelial cells adhesion property, acid resistance and to the antagonistic action of pathogen enterobacteria, also must satisfy some technical features, as mitotic stability, leavening property, can not influence product special flavour with other food ingredient combination, and have stable activity and physiological function (Mattila-Sandholm T., an et al.Technological challenges forfuture probiotic foods.Tnternational Dairy Journal 2002 (12): 173-182).However, the practical application of probiotic bacterium still has many restrictions, as its unstable performance under acidic conditions, o'clock extremely unstable in pH＜4 especially, nearly all probiotic bacterium viable bacteria number average under hydrochloric acid in gastric juice (pH2) condition can descend, therefore, have only the probiotic bacterium of trace to arrive enteron aisle and bring into play physiologically active.In order to address this problem, mainly discharge at food and pharmaceutical industry, but this is not basic technical solution, has limited the application of active bacteria formulation in other formulation by the through enteron aisle of viable capsule enteric coating technical protection viable bacteria.As seen; developing enteric coating microcapsule protection viable bacteria technology and formula for a product technology will make probiotic bacterium not only be applied in milk-product, beverage, the capsule; also can be extended to the non-dairy product Application Areas further; as normal temperature shelf-stable, the direct oral powder of probiotic bacterium of taking the through enteron aisle in back, tablet etc., and be the human consumer bring performance more superior, store, transport, carry more convenient probiotic products.
Summary of the invention
The present invention mainly solves existing probiotic bacterium based food, be difficult for keeping at normal temperatures stability and the unsettled technical problem under acidic conditions of probiotic bacterium, provide a kind of ambient stable to store, be fit to all groups, the edible composition and its preparation method that contain active probiotic, said composition essence is the composite symphysis unit preparation of probiotic bacterium and prebiotics, do not contain any sanitas, the powder of natural fruit taste type or tablet, easy to carry, directly take, it is very little that viable bacteria is influenced by hydrochloric acid in gastric juice, can go directly enteron aisle and bring into play physiologically active has the intestinal microflora of adjusting balance, control is because intestinal tract infections and the inflammatory bowel that gastrointestinal dysfunction causes, improve constipation and symptom of diarrhea, alleviate lactose intolerance, improve body non-specific immunity etc.
For solving the problems of the technologies described above, the present invention is achieved in that
A kind of edible composition that contains active probiotic is characterized in that it comprises viable bacteria powder 0.5-50%, prebiotics 4.5-99.5% and foodstuff additive 0-95% that (according to weight percent) handled through the microcapsule protection.
The raw material of this viable bacteria powder adopts Bacterium lacticum and/or bifidus bacillus.
This prebiotics is oligose or water-soluble dietary fibre.
These foodstuff additive are one or more in soybean protein powder, whey powder, skim-milk, sucrose, glucose, starch, lactose, maltodextrin, natural fruity powder, natural essence, the acidic flavoring agent.
A kind of above-mentioned preparation method who contains the edible composition of active probiotic is characterized in that, prepares according to following steps:
1. probiotic strain screening;
2. probiotic's culture;
3. viable bacteria powder preparation: mainly be divided into for three steps:
After a probiotic's culture finished, centrifugal collection bacterium mud added protective material;
B is with bacterium mud and protective material intimate mixing, lyophilize;
C is the capsule heart with above-mentioned lyophilize thing, selects for use water miscible coating material to carry out granule coating;
4. edible composition preparation: select one or more mixings by a certain percentage in prebiotics and the foodstuff additive for use, 20～80 mesh sieves are crossed in granulation, again with a certain amount of viable bacteria powder mixings that one or more are protected through microcapsule.
The screening of this probiotic strain is to separate probiotic bacterium from health adult and infant faeces, through Physiology and biochemistry binding molecule biology techniques, as pcr amplification, order-checking and sequential analysis technical evaluation isolated strains, by the bacteriostatic activity Analysis and Screening of strain fermentation performance, intestinal epithelial cells adhesion property, acid resistance and viable bacteria and meta-bolites, obtained performance strain excellent to pathogen enterobacteria and food spoilage microorganism.
This probiotic's culture mode adopts high density liquid to cultivate, and the initial pH of substratum is controlled at 5～9, and culture temperature is 35～42 ℃, and incubation time is as the criterion with fermentation termination pH3～5.
The protective material that adds in this viable bacteria powder preparation is one or more in starch, dextrin, lactose, sucrose, oligose, sugar alcohol, trehalose, soybean protein, whey-protein, glutamy sodium, vitamins C, the vitamin C sodium salt.
The water-soluble coating material that adopts in this viable bacteria powder capsule protection has the water-soluble coated product of German You Teqi (Eudragit) propenoic acid resin series; Various modified-cellulose class materials are as Vltra tears succsinic acid acetic ester, methylcellulose gum, Vltra tears etc.; And polysaccharose substance, as xanthan gum, trehalose, pectin, Lalgine, sodium alginate etc.Can adopt granule coating devices such as ebullated bed, fluidized-bed to carry out the microcapsule coating and shaping.
2. research process of the present invention:
Probiotic strain screening: from health adult and infant faeces, separate probiotic bacterium, be mainly Bacterium lacticum and bifidus bacillus, through Physiology and biochemistry binding molecule biology techniques, as passing through extracting genome DNA, 16S rDNA pcr amplification, order-checking and sequential analysis technical evaluation isolated strains.By the strain fermentation performance, the intestinal epithelial cells adhesion property, acid resistance and viable bacteria and meta-bolites are to pathogen enterobacteria, as intestinal bacteria, streptococcus aureus, clostridium perfringens, Shigellae etc. and food spoilage microorganism such as bacillus cereus, subtilis, the bacteriostatic activity Analysis and Screening of listeria bacteria etc., the obtained performance strain excellent is as Lactobacterium acidophilum (L.acidophilus), plant lactobacillus (L.plantarum), lactobacillus salivarius (L.salivarius), lactobacillus fermentum (L.fermentum), lactobacillus rhamnosus (L.rhamnosus), bifidus longum bb (B.longum), bifidobacterium breve (B.breve), bifidobacteria infantis (B.infantis), bifidobacterium adolescentis (B.adolescentis), bifidumbacterium bifidum (B.bifium) etc.
Probiotic's culture: the training method of probiotic bacterium can adopt high density liquid to cultivate, the cultivation of thalline there is no special regulation to the nutrition source in the substratum, can use the carbon source, nitrogenous source and other nutrient substance that are usually used in microorganism culturing, wherein carbon source can be glucose, sucrose, lactose, can adopt prebiotics as auxiliary carbon source such as oligofructose, oligomeric galactose, inulin, resistant dextrin and other water-soluble dietary fibre etc. especially; Nitrogenous source can be peptone, soyflour, meat extract, corn steep liquor and other organic or inorganic nitrogenous compound, then can suitably adopt bean sprouts juice, tomato juice, Radix Dauci Sativae juice, wort, vegetables juice and inorganic salt etc. as for other nutrition source.The initial pH of substratum is controlled at 5～9, with near neutral for well.Culture temperature is good with 35～38 ℃, and incubation time is as the criterion with fermentation termination pH3～5.
The present invention compared with prior art has following advantage:
1. microcapsule protection viable bacteria, ambient stable are compared with the probiotic bacterium capsule pharmaceutical with existing Dairy products probiotic bacterium, need not refrigeration, and product storage, transportation and cost of goods sold are low, and the quality guaranteed period reaches 2 years.
2. microcapsule are protected viable bacteria, and acidproof, oral postcolon target discharges, and compares with existing probiotic bacterium class capsule pharmaceutical, need not to add any sanitas or other any chemosynthesis material, can be made into powder or tablet, give the human consumer with the All Pure Nature green product.
3. the complex composition of probiotic bacterium and prebiotics both can have been brought into play the physiologically active of probiotic bacterium, and the quantity that can activate external probiotic supplemented again, optionally increases beneficial bacteria of intestinal tract makes the effect of probiotic bacterium more remarkable lasting.
Embodiment:
Embodiment 1: by the good strain Lactobacterium acidophilum of screening obtained performance, obtaining through processes such as cultivation, the protections of viable bacteria powder can be for the live lactobacillus acidophilus powder raw material of edible composition of the present invention, and viable count is greater than 2 * 10
11CFU/g.Make edible composition by following prescription:
Viable bacteria powder (2 * 10
11CFU/g) 0.5%
Oligofructose 40.5%
Xylo-oligosaccharide 9%
Inulin 20%
Resistant dextrin 30%
Embodiment 2: identical with above process, obtain plant lactobacillus, Lactobacterium acidophilum, bifidumbacterium bifidum viable bacteria powder, and viable count is greater than 5 * 10
10CFU/g.Make edible composition by following prescription:
Plant breast bacterium viable bacteria powder (5 * 10
10CFU/g) 1.5%
Live lactobacillus acidophilus powder (5 * 10
10CFU/g) 1.5%
Bifidumbacterium bifidum viable bacteria powder (5 * 10
10CFU/g) 1.5%
Resistant dextrin 60%
Xylo-oligosaccharide 35%
Oxysuccinic acid 0.5%
Green apple flavor essence 1 ‰
Embodiment 3: identical with above process, obtain Lactobacterium acidophilum, bifidobacteria infantis, bifidus longum bb viable bacteria powder, and viable count is greater than 1 * 10
11CFU/g.Make edible composition by following prescription:
Live lactobacillus acidophilus powder (1 * 10
11CFU/g) 20%
Bifidobacteria infantis viable bacteria powder (1 * 10
11CFU/g) 15%
Bifidus longum bb viable bacteria powder (1 * 10
11CFU/g) 15%
Oligomeric galactose 4.5%
Whey powder 45.5%
Embodiment 4: identical with above process, obtain lactobacillus salivarius, lactobacillus fermentum, lactobacillus rhamnosus, bifidus longum bb, bifidumbacterium bifidum, bifidobacterium breve viable bacteria powder, and viable count is greater than 1 * 10
10CFU/g.Make edible composition by following prescription:
Lactobacillus salivarius (1 * 10
10CFU/g) 5%
Lactobacillus fermentum (1 * 10
10CFU/g) 5%
Lactobacillus rhamnosus (1 * 10
10CFU/g) 5%
Bifidus longum bb (1 * 10
10CFU/g) 5%
Bifidumbacterium bifidum (1 * 10
10CFU/g) 5%
Bifidobacterium breve (1 * 10
10CFU/g) 5%
Locust tree glue hydrolyzate (dietary fiber content 80%) 30%
Xylo-oligosaccharide 20%
Skim-milk 10%
Maltodextrin 10%
Embodiment 5: identical with above process, obtain plant lactobacillus, bifidus longum bb viable bacteria powder, and viable count is greater than 2 * 10
10CFU/g.Make edible composition by following prescription:
Plant lactobacillus (2 * 10
10CFU/g) 15%
Bifidus longum bb (2 * 10
10CFU/g) 10%
Water-soluble dietary fibre 30%
Oligofructose 22%
Maltodextrin 23%
Embodiment 6: identical with above process, obtain lactobacillus fermentum, bifidobacterium adolescentis, bifidumbacterium bifidum viable bacteria powder, and viable count is greater than 1 * 10
11CFU/g.Make edible composition by following prescription:
Lactobacillus fermentum (1 * 10
11CFU/g) 4%
Bifidobacterium adolescentis (1 * 10
11CFU/g) 3%
Bifidumbacterium bifidum (1 * 10
11CFU/g) 3%
Inulin 75%
Starch 10%
Orange juice powder 5%
Embodiment 7: identical with above process, obtain lactobacillus salivarius, lactobacillus fermentum, bifidobacterium breve, bifidumbacterium bifidum viable bacteria powder, and viable count is greater than 1 * 10
10CFU/g.Make edible composition by following prescription:
Lactobacillus salivarius (1 * 10
10CFU/g) 3%
Lactobacillus fermentum (1 * 10
10CFU/g) 3%
Bifidobacterium breve (1 * 10
10CFU/g) 5%
Bifidumbacterium bifidum (1 * 10
10CFU/g) 4%
Xylo-oligosaccharide 30%
Resistant dextrin 40%
Lactose 15%
Embodiment 8: identical with above process, obtain lactobacillus salivarius, bifidobacterium adolescentis, bifidus longum bb viable bacteria powder, and viable count is greater than 3 * 10
10CFU/g.Make edible composition by following prescription:
Lactobacillus salivarius (3 * 10
10CFU/g) 13%
Bifidobacterium adolescentis (3 * 10
10CFU/g) 12%
Bifidus longum bb (3 * 10
10CFU/g) 10%
Oligofructose 30%
Water-soluble dietary fibre 15%
Glucose 10%
Sucus Mali pumilae powder 10%
Embodiment 9: identical with above process, obtain plant lactobacillus, Lactobacterium acidophilum, lactobacillus fermentum, lactobacillus rhamnosus viable bacteria powder, and viable count is greater than 1 * 10
10CFU/g.Make edible composition by following prescription:
Plant lactobacillus (1 * 10
10CFU/g) 10%
Lactobacterium acidophilum (1 * 10
10CFU/g) 10%
Lactobacillus fermentum (1 * 10
10CFU/g) 10%
Lactobacillus rhamnosus (1 * 10
10CFU/g) 10%
Resistant dextrin 30%
Inulin 10%
Sucrose 10%
Blueberry juice powder 10%
Embodiment 10: identical with above process, obtain bifidus longum bb, and viable count is greater than 1 * 10
11CFU/g.Make edible composition by following prescription:
Bifidus longum bb (1 * 10
11CFU/g) 10%
Water-soluble dietary fibre 40%
Xylo-oligosaccharide 30%
Maltodextrin 10%
Orange juice powder 10%
Claims (8)
1, a kind of edible composition that contains active probiotic is characterized in that it comprises viable bacteria powder 0.5-50%, prebiotics 4.5-99.5% and foodstuff additive 0-95% that (according to weight percent) handled through the microcapsule protection.
2, the edible composition that contains active probiotic according to claim 1 is characterized in that the raw material of this viable bacteria powder adopts Bacterium lacticum and/or bifidus bacillus.
3, the edible composition that contains active probiotic according to claim 1 is characterized in that this prebiotics is oligose or water-soluble dietary fibre.
4, the edible composition that contains active probiotic according to claim 1 is characterized in that these foodstuff additive are one or more in soybean protein powder, whey powder, skim-milk, sucrose, glucose, starch, lactose, maltodextrin, natural fruity powder, natural essence, the acidic flavoring agent.
5, a kind ofly it is characterized in that, prepare according to following steps as containing the preparation method of the edible composition of active probiotic as described in claim 1 or 2 or 3 or 4:
1. probiotic strain screening;
2. probiotic's culture;
3. viable bacteria powder preparation: mainly be divided into for three steps:
After a probiotic's culture finished, centrifugal collection bacterium mud added protective material;
B is with bacterium mud and protective material intimate mixing, lyophilize;
C is the capsule heart with above-mentioned lyophilize thing, selects for use water miscible coating material to carry out granule coating;
4. edible composition preparation: select one or more mixings by a certain percentage in prebiotics and the foodstuff additive for use, 20～80 mesh sieves are crossed in granulation, again with a certain amount of viable bacteria powder mixings that one or more are protected through microcapsule.
6, the preparation method who contains the edible composition of active probiotic according to claim 5, it is characterized in that the screening of this probiotic strain is to separate probiotic bacterium from health adult and infant faeces, through Physiology and biochemistry binding molecule biology techniques, as pcr amplification, order-checking and sequential analysis technical evaluation isolated strains, by the bacteriostatic activity Analysis and Screening of strain fermentation performance, intestinal epithelial cells adhesion property, acid resistance and viable bacteria and meta-bolites, obtained performance strain excellent to pathogen enterobacteria and food spoilage microorganism.
7, the preparation method who contains the edible composition of active probiotic according to claim 5, it is characterized in that this probiotic's culture mode adopts high density liquid to cultivate, the initial pH of substratum is controlled at 5～9, and culture temperature is 35～42 ℃, and incubation time is as the criterion with fermentation termination pH3～5.
8, the preparation method who contains the edible composition of active probiotic according to claim 5 is characterized in that the protective material that adds in this viable bacteria powder preparation is one or more in starch, dextrin, lactose, sucrose, oligose, sugar alcohol, trehalose, soybean protein, whey-protein, glutamy sodium, vitamins C, the vitamin C sodium salt.
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2003
- 2003-12-01 CN CNA2003101090007A patent/CN1545936A/en active Pending
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