CN1539479A - Drug for curing disease of proplapse of lumbar intervertebral disc - Google Patents
Drug for curing disease of proplapse of lumbar intervertebral disc Download PDFInfo
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- CN1539479A CN1539479A CNA2003101076495A CN200310107649A CN1539479A CN 1539479 A CN1539479 A CN 1539479A CN A2003101076495 A CNA2003101076495 A CN A2003101076495A CN 200310107649 A CN200310107649 A CN 200310107649A CN 1539479 A CN1539479 A CN 1539479A
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Abstract
A Chinese medicine for treating lumbar intervertebral disk protrusion is prepared from 41 Chinese-medicinal materials including Chinese angelica root, Chuan-xiong rhizome, ground beetle, myrrh, etc. Its advantages are high cura rate, quickly taking its effect and no toxic by-effect.
Description
Technical field: the present invention relates to a kind of medicine that is used for the treatment of prolapse of lumbar intervertebral disc, being specifically related to a kind of is the medicine that raw material is made with the Chinese herbal medicine.
Background technology: prolapse of lumbar intervertebral disc is because the lumbar intervertebral disc degenerative change, the vertebral pulp degeneration so that prominent rearward, bulging, a kind of that multiple pathological factor causes such as to deviate from be the disease of main clinic symptoms with pain.Because the characteristic of its physiological location, this is sick difficult to cure.The Chinese medicine for the treatment of prolapse of lumbar intervertebral disc at present clinically is a lot, but its prescription is all overcautiousser, and this class medicine of great majority can only play the effect of relief of symptoms, temporarily alleviates patient's misery, cures the symptoms, not the disease.
Summary of the invention: the purpose of this invention is to provide a kind of medicine for the treatment of the prolapse of lumbar intervertebral disc disease, it has reasonable recipe, instant effect, and curative effect is reliable, cure rate height, the characteristics that have no side effect.The present invention is made by following raw materials by weight portion: Radix Angelicae Sinensis 0.5～4, Rhizoma Chuanxiong 0.5～4, Rhizoma Et Radix Notopterygii 0.5～4, Eupolyphaga Seu Steleophaga 0.5～4, Bombyx Batryticatus 0.5～4, Rhizoma Homalomenae 0.5～4, Cortex schizophragmatis integrifolii radicis 0.5～4, Olibanum 0.5～4, Myrrha 0.5～4, process Radix Aconiti 0.5～4, Radix Aconiti Kusnezoffii Preparata 0.5～4, Radix Saposhnikoviae 0.5～4, Pheretima 1～5, Rhizoma Atractylodis 2～6, Semen Strychni (processed) 0.5～2.4, Radix Et Rhizoma Rhei (processed) 2～6, Sanguis Draxonis 0.2～2, Rhizoma Drynariae 2～6, Flos Carthami 2～6, Semen Persicae 1～5, Rhizoma Curcumae 2～6, rhizoma sparganic 1～5, Ramulus et Folium Bischofiae Javanicae 2～6, Radix Notoginseng 0.5～4, Oletum Trogopterori 1～5, Pyritum 0.2～2, Radix Paeoniae Rubra 1～5, Fructus Chaenomelis 2～6, Ramulus Cinnamomi 0.5～4, Herba Ephedrae 0.5～4, Radix Cyathulae 1～5, Herba Asari 0.2～2, Lignum Dalbergiae Odoriferae 0.5～4, Radix Clematidis 2～6, Agkistrodon 0.2～2, Caulis Lonicerae 0.2～2, Rhizoma Corydalis 2～6, Radix Glycyrrhizae 0.2～2, Rhizoma Gastrodiae 0.5～4, the Radix Aucklandiae 0.5～4, Scorpio 0.5～4.Preferred version of the present invention is made by following raw materials by weight portion: Radix Angelicae Sinensis 1～3, Rhizoma Chuanxiong 1～3, Rhizoma Et Radix Notopterygii 1～3, Eupolyphaga Seu Steleophaga 1～3, Bombyx Batryticatus 1～3, Rhizoma Homalomenae 1～3, Cortex schizophragmatis integrifolii radicis 1～3, Olibanum 1～3, Myrrha 1～3, process Radix Aconiti 1～3, Radix Aconiti Kusnezoffii Preparata 1～3, Radix Saposhnikoviae 1～3, Pheretima 2～4, Rhizoma Atractylodis 3～5, Semen Strychni (processed) 1～2.2, Radix Et Rhizoma Rhei (processed) 3～5, Sanguis Draxonis 0.5～1.5, Rhizoma Drynariae 3～5, Flos Carthami 3～5, Semen Persicae 2～4, Rhizoma Curcumae 3～5, rhizoma sparganic 2～4, Ramulus et Folium Bischofiae Javanicae 3～5, Radix Notoginseng 1～3, Oletum Trogopterori 2～4, Pyritum 0.5～1.5, Radix Paeoniae Rubra 2～4, Fructus Chaenomelis 3～5, Ramulus Cinnamomi 1～3, Herba Ephedrae 1～3, Radix Cyathulae 2～4, Herba Asari 0.5～1.5, Lignum Dalbergiae Odoriferae 1～3, Radix Clematidis 1～5, Agkistrodon 0.5～1.5, Caulis Lonicerae 0.5～1.5, Rhizoma Corydalis 3～5, Radix Glycyrrhizae 0.5～1.5, Rhizoma Gastrodiae 1～3, the Radix Aucklandiae 1～3, Scorpio 1～3.Preferred plan of the present invention is made by following raw materials by weight portion: Radix Angelicae Sinensis 2, Rhizoma Chuanxiong 2, Rhizoma Et Radix Notopterygii 2, Eupolyphaga Seu Steleophaga 2, Bombyx Batryticatus 2, Rhizoma Homalomenae 2, Cortex schizophragmatis integrifolii radicis 2, Olibanum 2, Myrrha 2, process Radix Aconiti 2, Radix Aconiti Kusnezoffii Preparata 2, Radix Saposhnikoviae 2, Pheretima 3, Rhizoma Atractylodis 4, Semen Strychni (processed) 2, Radix Et Rhizoma Rhei (processed) 4, Sanguis Draxonis 1, Rhizoma Drynariae 4, Flos Carthami 4, Semen Persicae 3, Rhizoma Curcumae 4, rhizoma sparganic 3, Ramulus et Folium Bischofiae Javanicae 4, Radix Notoginseng 2, Oletum Trogopterori 3, Pyritum 1, Radix Paeoniae Rubra 3, Fructus Chaenomelis 4, Ramulus Cinnamomi 2, Herba Ephedrae 2, Radix Cyathulae 3, Herba Asari 1, Lignum Dalbergiae Odoriferae 2, Radix Clematidis 4, Agkistrodon 1, Caulis Lonicerae 1, Rhizoma Corydalis 4, Radix Glycyrrhizae 1, Rhizoma Gastrodiae 2, the Radix Aucklandiae 2, Scorpio 2.Manufacture method of the present invention is: with above-mentioned 40 Herba indigoferae Pseudotinctoriae pulverizations, pharmaceutical methods is routinely made the watered pill of 0.1 grammes per square metre, packing.Medicine of the present invention is through clinical trial, and its result shows that it all has better curative effect to diseases such as prolapse of lumbar intervertebral disc, cervical spondylosis, lumbar vertebra hyperosteogeny, have reasonable recipe, instant effect, patient is painful few during the treatment, curative effect is reliable, cure rate height, the advantage that has no side effect.
Treatment prolapse of lumbar intervertebral disc, cervical spondylosis, lumbar vertebra hyperosteogeny disease pharmaceutical test summary:
One, clinical data:
Case is selected:
1, prolapse of lumbar intervertebral disc 90 examples, male's 62 examples wherein, women's 28 examples, at minimum 29 years old of age, maximum 55 years old, 43 years old mean age, the course of disease is the shortest 6 months, and was the longest 12 years.
2, cervical spondylosis 72 examples, male's 41 examples wherein, women's 31 examples, at minimum 33 years old of age, maximum 54 years old, 44 years old mean age, the course of disease is the shortest 1 year, and was the longest 9 years.
3, lumbar vertebra hyperosteogeny 30 examples, male's 18 examples wherein, women's 12 examples, minimum 44 years old of age, maximum 62 years old, 50 years old mean age, the course of disease 3 months to 5 years.
Two, the diagnostic criteria of disease:
1, prolapse of lumbar intervertebral disc: waist trauma history is in various degree arranged more, cardinal symptom is flank pain and lower limb radiated pain, lumbago is everlasting near the lumbosacral region, between the other spinous process of lumbar vertebra hypomere spinous process, dark tenderness is arranged, and be radiated to the shank outside, heel or the outside, instep downwards along the thigh rear side of Ipsilateral, mostly be the single lower limb pain.If intervertebral disk hernia is big or when being positioned at canalis spinalis central authorities, bilateral pain can be arranged.Cough sneeze, firmly during defecation, all can make nerve root nervous more and increase the weight of symptom, walking is bent over, is stretched knee joint and works the action of sitting back and waiting the tractive nerve root and make also that the pain increased.Bend hip, pain relief when going down on one's knees or lying up, the course of disease is than the radiation position of its lower limb pain of elder stolidity.Have that the part patient can ache with sciatica, spinal canal stenosis, lumbar muscle strain, rheumatic muscles and bones, arthralgia or numb limbs and tense tendons.
The X ray examination: the X-ray sheet can only be assisted diagnosis and can not be made a definite diagnosis, and can see that by the X-ray sheet physiologic radian of lumbar vertebra disappears, and the intervertebral space of pathological changes may be narrow, and hyperosteogeny is arranged during adjacent vertebral rim.
CT examination: nuclear magnetic resonance and myelography can be found out the intervertebral disc of pathological changes exactly, in conjunction with clinical symptoms as the standard made a definite diagnosis.
2, cervical spondylosis: do not have obvious trauma history, but minority is brought out by wound more.A lot of patients feel the shoulder, arm, numbness of hand wood pain of a side or gradually based on numbness, stretch behind the cervical region, cough in addition when increasing abdominal pressure pain increase the weight of.Part patient can have dizziness, tinnitus, otalgia, the power of holding to weaken and amyotrophy, and this class patient does not often have the cervical pain sensation.During inspection, going up the place, angle in hypomere cervical spine or the Ipsilateral scapula often has pressure pain point, part patient can touch the scleroma of rope strip, and restriction of neck motion, stiff is that main person can have pain to go down or grasp weakness with numbness.When neck 5～6 intervertebral pathological changes, stimulate the 6th nerve root can have patient's thumb or thumb, forefinger to feel to go down; When 6～7 intervertebral pathological changes, then stimulate the 7th nerve root can have food, middle finger to feel to go down.Can do the left and right sides comparison check.
Distraction test: patient's seat, stretch the deflection Ipsilateral behind the neck, the examiner is with its lower jaw of left hand holder, and the right hand presses down gradually from the crown, as cervical region pain occurs or radiating pain is the distraction test positive.Another kind of test: the Ipsilateral of examiner's one hand steered patient's head, another holds the Ipsilateral upper limb, and with its abduction 90 degree, two handss are made tractive in the other direction, if there is radiating pain also to be the distraction test positive.
The X ray examination: cervical vertebra just, the physiologic radian of the general visible cervical vertebra of lateral projection disappears or hyperosteogeny.
CT examination can be found the intervertebral disc of pathological changes.
3, lumbar vertebra hyperosteogeny:
The X ray examination: vertebral body and joint are just, the visible physiologic radian of lateral projection disappears, and the degeneration lip changes.
This disease has the symptom of part patient with scapulohumeral periarthritis, gout.
Three, the contained composition of medication: promptly by aforementioned 41 medicines of the present invention made of flavor Chinese herbal medicine, the watered pill of 0.1 grammes per square metre.
Four, administrated method: each oral 5 grams (about 50) day clothes secondary, early after ante cibum, the supper with 20 milliliters of yellow wine as priming, warm water delivery service, 45 days one courses of treatment.
The reaction that takes effect can appear in some patient in the medication process: a pain of crossing property increases the weight of, and the affected part heating is just like the Formica fusca walking, and to be that the efficacy of a drug is logical stagnate for this, because of blockage of meridian " stagnation of QI and blood may bring about pain, general rule are not bitterly " so.
Five, the criterion of curative effect:
1, recovery from illness: waist, hip, the pain that has a pain in the leg and sign disappear, and be movable normal.
2, produce effects: pain and sign are clearly better, and be movable normal.
3, effective: pain and sign turn for the better by and large, and activity is restricted slightly.
4, invalid: symptom and sign do not change.
Six, efficacy result analysis:
| Case | The example number | Recovery from illness (%) | Produce effects (%) | Effectively (%) | Invalid (%) | Total effective rate (%) |
| Prolapse of lumbar intervertebral disc | ??90 | ???79(88) | ???8(9) | ???2(2) | ??1(1) | ????99 |
| Cervical spondylosis | ??72 | ???60(83) | ???7(10) | ???3(4) | ??2(3) | ????97 |
| Lumbar vertebra hyperosteogeny | ??30 | ???23(77) | ???5(17) | ???1(3) | ??1(3) | ????97 |
The specific embodiment one: present embodiment is made by following raw materials by weight portion: Radix Angelicae Sinensis 0.5～4, Rhizoma Chuanxiong 0.5～4, Rhizoma Et Radix Notopterygii 0.5～4, Eupolyphaga Seu Steleophaga 0.5～4, Bombyx Batryticatus 0.5～4, Rhizoma Homalomenae 0.5～4, Cortex schizophragmatis integrifolii radicis 0.5～4, Olibanum 0.5～4, Myrrha 0.5～4, process Radix Aconiti 0.5～4, Radix Aconiti Kusnezoffii Preparata 0.5～4, Radix Saposhnikoviae 0.5～4, Pheretima 1～5, Rhizoma Atractylodis 2～6, Semen Strychni (processed) 0.5～2.4, Radix Et Rhizoma Rhei (processed) 2～6, Sanguis Draxonis 0.2～2, Rhizoma Drynariae 2～6, Flos Carthami 2～6, Semen Persicae 1～5, Rhizoma Curcumae 2～6, rhizoma sparganic 1～5, Ramulus et Folium Bischofiae Javanicae 2～6, Radix Notoginseng 0.5～4, Oletum Trogopterori 1～5, Pyritum 0.2～2, Radix Paeoniae Rubra 1～5, Fructus Chaenomelis 2～6, Ramulus Cinnamomi 0.5～4, Herba Ephedrae 0.5～4, Radix Cyathulae 1～5, Herba Asari 0.2～2, Lignum Dalbergiae Odoriferae 0.5～4, Radix Clematidis 2～6, Agkistrodon 0.2～2, Caulis Lonicerae 0.2～2, Rhizoma Corydalis 2～6, Radix Glycyrrhizae 0.2～2, Rhizoma Gastrodiae 0.5～4, the Radix Aucklandiae 0.5～4, Scorpio 0.5～4.
The specific embodiment two: present embodiment is made by following raw materials by weight portion: Radix Angelicae Sinensis 1～3, Rhizoma Chuanxiong 1～3, Rhizoma Et Radix Notopterygii 1～3, Eupolyphaga Seu Steleophaga 1～3, Bombyx Batryticatus 1～3, Rhizoma Homalomenae 1～3, Cortex schizophragmatis integrifolii radicis 1～3, Olibanum 1～3, Myrrha 1～3, process Radix Aconiti 1～3, Radix Aconiti Kusnezoffii Preparata 1～3, Radix Saposhnikoviae 1～3, Pheretima 2～4, Rhizoma Atractylodis 3～5, Semen Strychni (processed) 1～2.2, Radix Et Rhizoma Rhei (processed) 3～5, Sanguis Draxonis 0.5～1.5, Rhizoma Drynariae 3～5, Flos Carthami 3～5, Semen Persicae 2～4, Rhizoma Curcumae 3～5, rhizoma sparganic 2～4, Ramulus et Folium Bischofiae Javanicae 3～5, Radix Notoginseng 1～3, Oletum Trogopterori 2～4, Pyritum 0.5～1.5, Radix Paeoniae Rubra 2～4, Fructus Chaenomelis 3～5, Ramulus Cinnamomi 1～3, Herba Ephedrae 1～3, Radix Cyathulae 2～4, Herba Asari 0.5～1.5, Lignum Dalbergiae Odoriferae 1～3, Radix Clematidis 1～5, Agkistrodon 0.5～1.5, Caulis Lonicerae 0.5～1.5, Rhizoma Corydalis 3～5, Radix Glycyrrhizae 0.5～1.5, Rhizoma Gastrodiae 1～3, the Radix Aucklandiae 1～3, Scorpio 1～3.
The specific embodiment three: present embodiment is made by following raw materials by weight portion: Radix Angelicae Sinensis 2, Rhizoma Chuanxiong 2, Rhizoma Et Radix Notopterygii 2, Eupolyphaga Seu Steleophaga 2, Bombyx Batryticatus 2, Rhizoma Homalomenae 2, Cortex schizophragmatis integrifolii radicis 2, Olibanum 2, Myrrha 2, process Radix Aconiti 2, Radix Aconiti Kusnezoffii Preparata 2, Radix Saposhnikoviae 2, Pheretima 3, Rhizoma Atractylodis 4, Semen Strychni (processed) 2, Radix Et Rhizoma Rhei (processed) 4, Sanguis Draxonis 1, Rhizoma Drynariae 4, Flos Carthami 4, Semen Persicae 3, Rhizoma Curcumae 4, rhizoma sparganic 3, Ramulus et Folium Bischofiae Javanicae 4, Radix Notoginseng 2, Oletum Trogopterori 3, Pyritum 1, Radix Paeoniae Rubra 3, Fructus Chaenomelis 4, Ramulus Cinnamomi 2, Herba Ephedrae 2, Radix Cyathulae 3, Herba Asari 1, Lignum Dalbergiae Odoriferae 2, Radix Clematidis 4, Agkistrodon 1, Caulis Lonicerae 1, Rhizoma Corydalis 4, Radix Glycyrrhizae 1, Rhizoma Gastrodiae 2, the Radix Aucklandiae 2, Scorpio 2.
Claims (3)
1, a kind of medicine for the treatment of the prolapse of lumbar intervertebral disc disease is characterized in that it is made by following raw materials by weight portion: Radix Angelicae Sinensis 0.5～4, Rhizoma Chuanxiong 0.5～4, Rhizoma Et Radix Notopterygii 0.5～4, Eupolyphaga Seu Steleophaga 0.5～4, Bombyx Batryticatus 0.5～4, Rhizoma Homalomenae 0.5～4, Cortex schizophragmatis integrifolii radicis 0.5～4, Olibanum 0.5～4, Myrrha 0.5～4, process Radix Aconiti 0.5～4, Radix Aconiti Kusnezoffii Preparata 0.5～4, Radix Saposhnikoviae 0.5～4, Pheretima 1～5, Rhizoma Atractylodis 2～6, Semen Strychni (processed) 0.5～2.4, Radix Et Rhizoma Rhei (processed) 2～6, Sanguis Draxonis 0.2～2, Rhizoma Drynariae 2～6, Flos Carthami 2～6, Semen Persicae 1～5, Rhizoma Curcumae 2～6, rhizoma sparganic 1～5, Ramulus et Folium Bischofiae Javanicae 2～6, Radix Notoginseng 0.5～4, Oletum Trogopterori 1～5, Pyritum 0.2～2, Radix Paeoniae Rubra 1～5, Fructus Chaenomelis 2～6, Ramulus Cinnamomi 0.5～4, Herba Ephedrae 0.5～4, Radix Cyathulae 1～5, Herba Asari 0.2～2, Lignum Dalbergiae Odoriferae 0.5～4, Radix Clematidis 2～6, Agkistrodon 0.2～2, Caulis Lonicerae 0.2～2, Rhizoma Corydalis 2～6, Radix Glycyrrhizae 0.2～2, Rhizoma Gastrodiae 0.5～4, the Radix Aucklandiae 0.5～4, Scorpio 0.5～4.
2, a kind of medicine for the treatment of the prolapse of lumbar intervertebral disc disease according to claim 1 is characterized in that it is made by following raw materials by weight portion: Radix Angelicae Sinensis 1～3, Rhizoma Chuanxiong 1～3, Rhizoma Et Radix Notopterygii 1～3, Eupolyphaga Seu Steleophaga 1～3, Bombyx Batryticatus 1～3, Rhizoma Homalomenae 1～3, Cortex schizophragmatis integrifolii radicis 1～3, Olibanum 1～3, Myrrha 1～3, process Radix Aconiti 1～3, Radix Aconiti Kusnezoffii Preparata 1～3, Radix Saposhnikoviae 1～3, Pheretima 2～4, Rhizoma Atractylodis 3～5, Semen Strychni (processed) 1～2.2, Radix Et Rhizoma Rhei (processed) 3～5, Sanguis Draxonis 0.5～1.5, Rhizoma Drynariae 3～5, Flos Carthami 3～5, Semen Persicae 2～4, Rhizoma Curcumae 3～5, rhizoma sparganic 2～4, Ramulus et Folium Bischofiae Javanicae 3～5, Radix Notoginseng 1～3, Oletum Trogopterori 2～4, Pyritum 0.5～1.5, Radix Paeoniae Rubra 2～4, Fructus Chaenomelis 3～5, Ramulus Cinnamomi 1～3, Herba Ephedrae 1～3, Radix Cyathulae 2～4, Herba Asari 0.5～1.5, Lignum Dalbergiae Odoriferae 1～3, Radix Clematidis 1～5, Agkistrodon 0.5～1.5, Caulis Lonicerae 0.5～1.5, Rhizoma Corydalis 3～5, Radix Glycyrrhizae 0.5～1.5, Rhizoma Gastrodiae 1～3, the Radix Aucklandiae 1～3, Scorpio 1～3.
3, a kind of medicine for the treatment of the prolapse of lumbar intervertebral disc disease according to claim 1 is characterized in that it is made by following raw materials by weight portion: Radix Angelicae Sinensis 2, Rhizoma Chuanxiong 2, Rhizoma Et Radix Notopterygii 2, Eupolyphaga Seu Steleophaga 2, Bombyx Batryticatus 2, Rhizoma Homalomenae 2, Cortex schizophragmatis integrifolii radicis 2, Olibanum 2, Myrrha 2, process Radix Aconiti 2, Radix Aconiti Kusnezoffii Preparata 2, Radix Saposhnikoviae 2, Pheretima 3, Rhizoma Atractylodis 4, Semen Strychni (processed) 2, Radix Et Rhizoma Rhei (processed) 4, Sanguis Draxonis 1, Rhizoma Drynariae 4, Flos Carthami 4, Semen Persicae 3, Rhizoma Curcumae 4, rhizoma sparganic 3, Ramulus et Folium Bischofiae Javanicae 4, Radix Notoginseng 2, Oletum Trogopterori 3, Pyritum 1, Radix Paeoniae Rubra 3, Fructus Chaenomelis 4, Ramulus Cinnamomi 2, Herba Ephedrae 2, Radix Cyathulae 3, Herba Asari 1, Lignum Dalbergiae Odoriferae 2, Radix Clematidis 4, Agkistrodon 1, Caulis Lonicerae 1, Rhizoma Corydalis 4, Radix Glycyrrhizae 1, Rhizoma Gastrodiae 2, the Radix Aucklandiae 2, Scorpio 2.
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| CNB2003101076495A CN1250276C (en) | 2003-10-30 | 2003-10-30 | Drug for curing disease of proplapse of lumbar intervertebral disc |
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| CNB2003101076495A CN1250276C (en) | 2003-10-30 | 2003-10-30 | Drug for curing disease of proplapse of lumbar intervertebral disc |
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