CN1537648A - Saccule catheter type tumour close internal radiation therapy device - Google Patents
Saccule catheter type tumour close internal radiation therapy device Download PDFInfo
- Publication number
- CN1537648A CN1537648A CNA2003101080895A CN200310108089A CN1537648A CN 1537648 A CN1537648 A CN 1537648A CN A2003101080895 A CNA2003101080895 A CN A2003101080895A CN 200310108089 A CN200310108089 A CN 200310108089A CN 1537648 A CN1537648 A CN 1537648A
- Authority
- CN
- China
- Prior art keywords
- conduit
- tumor
- radioactive
- sacculus
- mini
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Radiation-Therapy Devices (AREA)
Abstract
A spherical-bag catheter-type near-distance radiotherapeutic apparatus for tumor is composed of catheter, spherical bag, liquid radioactive source and pouring unit. It features that a catheter with front end in spherical bag shape is transplanted in the tumor tissue, and the liquid or granular radioactive source in the physiological saline contained in said spherical bag can kill the tumor cells.
Description
Technical field: the present invention relates to closely internal radiotherapy device of a kind of tumor, be particularly related to and a kind ofly implant the liquid condition mini-radioactive resource between tumor tissues or the tumor of tumor bed internal radiotherapy device closely in balloon type conduit mode, the tumor cell around can killing effectively by this device.
Background technology: tumour radiotherapy is a tumor therapeuticing method effective, that extensively adopt, especially to the patient of tumor resection in conjunction with art before, postoperation radiotherapy can kill remaining tumor cell effectively, prevent tumor recurrence, obviously improve the tumour patient five year survival rate.Tumour radiotherapy comprises outer radiotherapy and closely internal radiotherapy at a distance, the outer radiotherapy of tumor is normally by large-scale radiotherapy equipments such as linear acceleratoies, outside the patient body with etc. the center mode aim at internal lesions, with high X heat input destroyed tumor cell; Tumor is internal radiotherapy closely, is to be undertaken by the mode that adopts afterloading unit or adopt radioactive particulate to implant.Because the outer radiotherapy of tumor is bigger to normal tissue injury, can cause than severe complications and sequela, thereby the tumor that directly is seated in the tumor surrounding tissue closely internal radiotherapy popularized application gradually, especially the Therapeutic Method of going into miniature radioactive source at the tumor tissues inter-planting is subjected to most clinicists' approval especially.Radiotherapy is meant in the mini-radioactive resource implantation tumour or be subjected in the tissue of tumor-infiltrated infringement between tumor tissues, the lasting low-energy gamma-radiation that sends by mini-radioactive resource, make tumor tissues suffer farthest to kill, and normal structure is injury-free or only be subjected to slight damage.The most frequently used method of clinical medicine circle is to adopt at present
125I or
103The Pd microgranule is directly planted in tumor tissues or is subjected in the tissue of tumor-infiltrated infringement.Chinese invention patent (number of patent application 00127851.7) " inter-planting of organizing of tumor is gone into the Therapeutic Method and the implantation device thereof of miniature radioactive source " disclosed method, and the disclosed method of Chinese invention patent (number of patent application 01109091.X) " in the cancer art between (Wicresoft) tissue 3 D stereo directional radiotherapy eutical system ", all are methods of the above-mentioned type.Although this method can be killed tumor cell effectively in closely, but because every radioactive source microgranule volume is very little, usually need plant 10～40 radioactive source microgranules at least in each tumor tissues, and all need to adopt puncture hollow needle puncture tissue when planting each microgranule, and be fixed on the puncture fixing head, the employing plastic catheter is inserted, the program of plantation radioactive source microgranule, therefore repeatedly puncture, plant at same tissue, bigger for local tissue damage, cause local hemorrhage and tissue injury easily; Radioactive source microgranule ambient radiation week is directly too small, is not easy control, can not kill tumor cell with the most rational radiation mode; In case behind the plantation radioactive source microgranule, be to belong to nonvolatil; The radiation of initial planting radioactive source microgranule may cause patient, family members and medical personnel's radiation injury; Program complexity during plantation needs special-purpose plantation instrument and equipment, and each conduit and mini-radioactive resource that consumes costs an arm and a leg, and common patient difficulty bears.
Summary of the invention: in view of the weak point of plantation mini-radioactive resource microgranule Therapeutic Method between above-mentioned tumor tissues, task of the present invention is to propose the closely method and apparatus of internal radiotherapy of a kind of novel tumor, can give full play to the tumor tissues inter-planting and go into the advantage of miniature radioactive source Therapeutic Method, but avoid in its operating process to tissue injury big, hemorrhage many, operation sequence is complicated, consumable material cost height, shortcoming that expense is big.
The present invention overcomes the technical scheme that above-mentioned technical problem proposes, it is characterized in that, adopt front end to have the conduit of spherical air bag, be placed in the tumor tissues or be subjected in the tissue of tumor-infiltrated infringement or in the tumor bed behind the tumor resection tissue, in spherical air bag, pour into and (for example have liquid condition man-made isotope radioactive source
125I) normal saline makes the mini-radioactive resource that is full of in the spherical air bag kill tumor cell with spherical direction radiation lonizing radiation; Perhaps in spherical air bag, pour into normal saline, make its airbag inflation in tumor tissues, in conduit, insert then
192The Ir microgranule (by after put penetrate therapy equipment), adopt the high dose lonizing radiation to kill tumor cell on every side, withdraw from after several minutes
192The Ir microgranule is got back to afterloading unit.
Technical characterictic of the present invention is the front end that the supravasal sacculus 601 of balloon type is fixed on conduit 602, between the two by sacculus fixed layer 606 tight adhesion, conduit 602 implanting saccule at front end perfusing holes are communicated with balloon lumen 609 and conduit cavity 618, the normal saline of perfusion balloon catheter, or contain the normal saline of liquid radioactive source, or
192Ir microgranule lead all can inject in the conduit from conduit side mouth 613, conduit side mouth stopper rod 614 can complete closed conduit side mouth, the conduit cavity stopper rod 611 that has snaphead can the closes ducts inner chamber, catheter wall 608 adopts the material manufacture that prevents x radiation x, when aqueous radioactive source or microgranular radioactive source enter in the tumor tissues by it, radiation is intercepted, and can not damage surrounding tissue.
Technical characterictic of the present invention is, the foley's tube type closely mini-radioactive resource that adopts of internal radiotherapy device is the mini-radioactive resource of liquid condition, and the mini-radioactive resource of this liquid condition is
125I,
103Pd,
198Man-made isotope radioactive sources such as Au, the radiation gamma-radiation, its half-life is shorter, about 56 days, activity produces the heat spot of damage normal structure by force and not to the lethality of tumor, be easy to protection, be to have proved that at present clinical efficacy is distinguished, the radioactive source that safety is good, this liquid radioactive source is water soluble state, can be water-soluble, can freely mix with normal saline and can not produce the precipitation or degeneration, rotten, its naked back dress activity is 200～450mci, by the doctor of radiotherapy section by selecting the different size air bag and selecting different volume liquid radioactive sources to pour into and regulate.
Technical characterictic of the present invention is, perfusion contains liquid mini-radioactive resource saline, and to enter conduit and sacculus be to adopt to have special preventer, finish by automatization's control mode driving peristaltic pump and electromagnetic valve, the perfusion pipeline 202 that peristaltic pump 203 drives directly is connected conduit side mouth 613, conduit cavity stopper rod 611 is drawn out of and is fixed on conduit side mouth 613 openings below, air filter electromagnetic valve 208 is open, peristaltic pump counterclockwise rotates air in the suction channel, air filter 207 can hinder microorganism and enter pipeline, when in vacuum indicating gage in the pipeline shows circulating line, being negative pressure, peristaltic pump 203 automatic feedback stops rotate, normal saline pipeline electromagnetic valve 210 is open automatically, the instruction of importing in advance according to operator, the normal saline of input prescribed dose, the normal saline groundwater increment depends on the volume of tumor focus and classification by stages, and the selection of air bag sphere volume, the general air bag bulb diameter 2cm～4cm that selects, perfusion normal saline dosage is generally selected 4ml～35ml in the sacculus, the doctor determines according to patient by Radiotherapy, should slowly carry out during the normal saline perfusion, mainly prevent balloon rupture, rate of flooding is per minute 5ml～10ml, can control automatically and select, after finishing the perfusion normal saline, electromagnetic valve 210 cuts out, the peristaltic pump stop rotates, and operator select the dosage of perfusion fluid radioactive source, adopt 1ml～5ml usually, preferably pour into the liquid radioactive source of 1.5ml～2ml, the most frequently used liquid radioactive source can be selected
125I., best naked back dress is active in 150mci～250mci, is determined according to patient's state of an illness by the doctor.After operator preset the instruction of perfusion dosage; the automatically open liquid radioactive source perfusion of device pipeline electromagnetic valve 205; peristaltic pump 203 rotates clockwise; liquid radioactive source slowly input pipe and balloon capsule in the special-purpose radiological protection container; rate of flooding 10ml/ minute; above-mentioned perfusion EP (end of program); conduit cavity stopper rod 611 is all got back into conduit cavity; the complete closed conduit cavity; the general therapeutic time is 6～10 minutes, after liquid radioactive source is retained 6～10 minutes in the sacculus, slowly extracts conduit cavity stopper rod 611 out to conduit side mouth 613 belows; it is open to reclaim liquid pipeline electromagnetic valve 212; peristaltic pump counterclockwise rotates, and reclaims liquid and all imports recovery liquid container 214 from sacculus to conduit, purifies through TFF; after removing normal saline, liquid radioactive source can be reused.
Above-mentioned novel tumor by perfusion fluid shape mini-radioactive resource in the balloon type conduit is organized closely internal radiotherapy device of tumor that inter-planting goes into miniature radioactive source, can be widely used in closely internal radiotherapy of various malignant tumor, comprise untreated primary tumor, need to preserve the tumor palliative excision of vital tissue, for preventing the preventative local radiotherapy of tumor recurrence, and recurrent or transfevent tumor etc., the using method of device, can be in operation, to preset the balloon type conduit, and perfusion fluid shape radioactive source and normal saline are retained in the focus, take out balloon type conduit, for example cerebral glioma patient postoperative internal radiotherapy with simple operation after 5～7 days; Also can in operation, preset the tumor bed that the balloon type conduit has excised at tumor tissues, full normal saline in the sacculus, conduit does not hold indwelling external, every day twice perfusion fluid shape radioactive source, extract out after 6～10 minutes, continue 5～7 days, internal radiotherapy closely behind the mammary cancer surgery for example, perhaps be used for the tract internal radiotherapy, as epimere esophageal carcinoma patient, the closely internal radiotherapy that carries out under the esophagoscope guiding can also be the closely internal radiotherapy of inserting conduit in in-vitro percutaneous puncture, for example, the closely internal radiotherapy of carcinoma of prostate patient's balloon type conduit percutaneous puncture.
Technical characterictic of the present invention is, the balloon type conduit closely mini-radioactive resource of internal radiotherapy device employing can also be the radioactive source microgranule of solid state, this microgranule links to each other with back dress internal radiotherapy device by lead, and high dose rate (the High Dore Rate HDR) mini-radioactive resource of afterloading unit employing is a solid usually
192The Ir microgranule links to each other with lead, adopts computer control, and this Therapeutic Method must adopt the conduit that has the conduit exocoel.Place the balloon type conduit in the tumor tissues, be subjected to tumor tissues to soak between surrounding tissue or in the tumor bed of tumor resection tissue after, extract conduit exocoel stopper rod 305 out, the normal saline of intracavity perfusion specified volume outside conduit, through conduit exocoel perfusing hole 308 to sacculus, use conduit exocoel stopper rod 305 closes ducts exocoels 304 then, the radioactive substance microgranule 301 of putting into lead 302 connections in conduit cavity 306 is to the sacculus position, about 6～10 minutes, extract the radioactive source microgranule out, with inner chamber stopper rod closes ducts inner chamber, finish therapeutic process.The method and apparatus of this employing solid, shaped radioactive source microgranule is suitable for the clinical practice of aforesaid liquid shape radioactive source equally, and the treatment indication is identical.
The invention has the beneficial effects as follows, when giving full play to the tumor tissues inter-planting and going into miniature radioactive source Therapeutic Method advantage, avoided many conduits to implant big, hemorrhage many, cost is high, operation sequence the is complicated shortcoming of a plurality of solid source microgranules caused tissue injurys, only implant a conduit and obtain better curative effect with regard to replacing inserting tens of conduits simultaneously, and because the position of sacculus between tissue, can kill tumor cell better and avoid damage normal cell on every side, operation sequence is simple, cost is low, reduce patient's burden, promotes than being easier to.
Description of drawings: the invention will be further described below in conjunction with drawings and Examples
Fig. 1 is a balloon type guide-tube structure sketch map of the present invention
Fig. 2 contains radioactive substance liquid perfusion principle and device sketch map thereof
Fig. 3 is a balloon type conduit applying solid radioactive source microgranule sketch map
Among the figure: the 601-sacculus, the 602-conduit, 603-internal layer sacculus, the outer sacculus of 604-, 605-sacculus perfusing hole, 606-sacculus fixed layer, 608-catheter wall, the 609-balloon lumen, the 610-conduit outlet, 611-conduit cavity stopper rod, 612-inner chamber stem handles, 613-conduit side mouth, 614-conduit side mouth stopper rod, 615-side mouth stem handles, 618-conduit cavity, 619-conduit metal marker thing, 201-pours into the liquid to the sacculus, and 202-pours into pipeline, 203-peristaltic pump, 204-radiological defense cover, 205-liquid radiation source container, 206-normal saline container, 207-air filter, 208-electromagnetic valve 1 ' (air line electromagnetic valve), 209-electromagnetic valve 2 ' (liquid radioactive source pipeline electromagnetic valve), 210-electromagnetic valve 3 ' (normal saline pipeline electromagnetic valve), 212-electromagnetic valve 4 ' (reclaiming liquid pipeline electromagnetic valve), 214-reclaims the liquid pipeline, 301-solid source microgranule, 302-solid source microgranule lead, 303-afterloader, 304-conduit exocoel, 305-conduit exocoel stopper rod, 306-conduit cavity, 307-conduit cavity tube wall, 308-conduit exocoel perfusing hole, 309-conduit exocoel stem handles
The specific embodiment: in the embodiment shown in fig. 1, be balloon type guide-tube structure sketch map of the present invention.The balloon type conduit is made up of conduit 602 and the sacculus 601 that sticks to its front end; conduit 602 is by catheter wall 608; conduit outlet 610; conduit cavity 618; sacculus perfusing hole 605; conduit side mouth 613 is formed; conduit cavity is sealed by conduit outlet 610 by the conduit cavity stopper rod 611 that can move freely; conduit cavity stem handles 612 connecting duct stopper rods 611; conduit side mouth stopper rod 614 can closes ducts side mouth 613; sacculus 601 is a double-decker; internal layer sacculus 603 constitutes balloon lumen 609; be used for holding dabbling liquid; outer sacculus 604 is used for shielding; in case internal layer sacculus 603 breaks; outer sacculus 604 can hold the liquid of leakage; seal with sacculus fixed layer 606 between sacculus 601 and the conduit 602; carry out traffic by sacculus perfusing hole 605; the sealing mode preferably adopts adhesive bond, also can adopt the latch closure mode to fix.Conduit outer wall has metal marker thing 619 labellings, clear and definite catheter position when guaranteeing imaging examination and location, the metal marker thing can adopt various metal materials, adopt the various known method labelling, can be to adopt ion air brushing mode or ion physical method or ion chemistry mode to be deposited on conduit outer wall, metal material preferably adopts the precious metal material gold, silver, platinum, platinum etc., can keep the tube wall flexibility, do not react with tissue, biological compliance is good, and conduit, sacculus, stopper rod all adopts nontoxic, the good medical grade silicon rubber material of biological compliance, through meeting the medical grade standard fabrication, need before all balloon type conduits dispatch from the factory through the pressure withstand voltage test, sacculus must be withstand voltage, do not break.The balloon type conduit is disposable operative installations, promptly abandons after the use, can consider that to same patient limited number of times is reused behind strict disinfection with high pressure steam.The balloon type conduit is packed into standby in the aseptic packaging; catheter wall 608 contains can prevent X line penetrable material; during mini-radioactive resource process conduit cavity 609; the anti-X line penetrable material that contains in the catheter wall 608 is enough to hinder the leakage of radiation; guarantee normal body tissue and not raying of surrounding, guarantee doctor, operator and patient's radiation safety.
In the embodiment that Fig. 2 shows, be to contain radioactive substance liquid filling device sketch map among the present invention.Device covers (dotted line partly among the figure) by radiological defense cover 204, protective cover 204 is by the sheet metal manufacturing, thickness is 0.5cm～1cm, can the radiation of barrier liquid radioactive source, perfusion pipeline 202 adopts the silicone rubber that contains heavy metal lead or other metal materials with pipe side mouth 613 connecting pipes, when guaranteeing the perfusion fluid radioactive source, surrounding is not leaked.Other all pipelines, device, container all is placed in the protective cover 204, guarantee that radiationless line leaks environment around, 204 of protective covers are as shell, outer surface spraying plastic paint, device is managed by microcomputer singlechip, implement automatization's control, peristaltic pump 203 constitutes liquid driving device, be that digitized shows and the Digital Control type, control and its duty of demonstration and speed on liquid crystal display screen by microcomputer singlechip, duty and speed all can be controlled automatically, automatically regulate, electromagnetic valve 1 '-208 control air line, air filter 209 adopts supermicro filtration membrane, can free exchanging gas, but dust can be hindered and microorganism enters pipeline, electromagnetic valve 2 '-209 controlling liquid radioactive source pipeline, contain fluid radioactive source in the liquid radiation source container 205, for metal material is made (0.5cm～1cm metallic plate), can hinder the radioactive source radiation leaks, electromagnetic valve 3 '-210 control normal saline pipeline holds normal saline in the normal saline container 206, and liquid liquid is reclaimed in electromagnetic valve 4 '-212 control, withdrawal liquid container 214 is made for metallic sheet stock, is used for holding the normal saline and the liquid radioactive source of recovery.
In the embodiment that Fig. 3 shows, be foley's tube applying solid shape mini-radioactive resource sketch map.This is that adopt a kind of is different from classical balloon type conduit, special design is applied to use the special balloon type conduit of solid, shaped mini-radioactive resource, this conduit increases a conduit exocoel 304, and by conduit exocoel perfusing hole 308 and sacculus 601 traffic, conduit exocoel 304 is used for pouring into normal saline specially, with dilatation balloon, conduit exocoel stopper rod 305, can fill the closes ducts exocoel, conduit exocoel stem handles 306 helps stopper rod and moves freely, place the pre-determined target position and in sacculus, pour into normal saline at the balloon type conduit, make sacculus full, after surrounding tissue is pushed in extruding open, extract the conduit cavity stopper rod and in conduit cavity 306, insert the solid, shaped mini-radioactive resource microgranule 301 of band lead 302 to sacculus 601 positions, mini-radioactive resource microgranule lead 302 other ends connect the after-loading therapy device, and it moves by micro computer and step motor control.Interior radiation plan therapy system is the basic configuration of after-loading therapy device; the doctor is according to the left alone without help position of staying of patient decision solid, shaped mini-radioactive resource microgranule; and in this position the left alone without help time of staying, finish back automatic drawing back mini-radioactive resource microgranule and lead is got back in the protective cover of after-loading therapy device in treatment.
Be another embodiment of the present invention below, patient: the woman, 45 years old, clinical diagnosis was an II phase left side breast carcinoma.Patient implements local lumpectomy, before operation finishes, it is the balloon type conduit (shown in Figure 3) of 2cm that the doctor places diameter in the tumor bed of tumor resection, in conduit exocoel 304, inject the 5ml normal saline, fill and the closes ducts exocoel with conduit exocoel stopper rod 305, conduit 602 do not hold stay external, do not hold with suture and skin at it and to fix, wrap up with antiseptic gauze the outside, the hands second day after operation rises, begin to carry out in the sacculus closely internal radiotherapy, select the solid, shaped mini-radioactive resource microgranule of after-loading therapy device
192Ir is the treatment radioactive source, extract the conduit cavity stopper rod out, mini-radioactive resource microgranule 301 and lead 302 thereof are put into conduit cavity, the closely internal radiotherapy plan of working out according to the doctor by the microcomputer control system of after-loading therapy device, mini-radioactive resource microgranule 301 is delivered to expansible all the time sacculus position by lead 302, and stay 6 minutes according to preset time is left alone without help, then, extract the mini-radioactive resource microgranule 301 of band lead 302 out, fill and closes ducts inner chamber 306 with the conduit cavity stopper rod, with the wrapping of the husky cloth of sterilization, sacculus internal radiotherapy every day twice, continue 5 days, extract normal saline out from the conduit exocoel, allow after the sacculus atrophy, extract conduit out, wound closure.
Foley's tube type closely internal radiotherapy device is the closely internal radiotherapy device that a kind of tumor tissues inter-planting of innovation is gone into miniature radioactive source, not only can be used for the first-selected treatment of primary tumor, for example carcinoma of prostate etc.; Also can be used to the tumor palliative operation that keeps vital tissue and implement, keep laryngeal nerves, perhaps be used for tumor to have invaded the palliative operation that vital tissue can only carry out, invade pericardium as pulmonary carcinoma as thyroid carcinoma; Also can be used for spreading around the prophylaxis of tumours, though the focus surrounding tissue of carrying out the tumor radical cure surgical patient is treated; Can also be used for the primary tumor that to perform the operation, or cooperate outer radiotherapy simultaneously.
Claims (9)
1. tumor internal radiotherapy device closely, be a kind of with the tumor of balloon type conduit mode implantable miniature radioactive source between tumor tissues internal radiotherapy device closely, form by conduit 602, sacculus 601, liquid mini-radioactive resource and device for casting or solid mini-radioactive resource and driving device, it is characterized in that, adopt front end to have the conduit of spherical air bag, be placed in the tumor tissues or be subjected in the tissue of tumor-infiltrated infringement or in the tumor bed behind the tumor resection tissue, in spherical air bag, pour into and (for example have liquid condition man-made isotope radioactive source
125I) normal saline makes the mini-radioactive resource that is full of in the spherical air bag kill tumor cell with spherical direction radiation lonizing radiation; Perhaps in spherical air bag, pour into normal saline, make its airbag inflation in tumor tissues, in conduit, insert then
192The Ir microgranule (by after put penetrate therapy equipment), adopt the high dose lonizing radiation to kill tumor cell on every side.
2. at the described foley's tube type of claim 1 tumor internal radiotherapy device closely, it is characterized in that, the supravasal sacculus 601 of balloon type is fixed on the front end of conduit 602, between the two by sacculus fixed layer 606 tight adhesion, conduit 602 implanting saccule at front end perfusing holes are communicated with balloon lumen 609 and conduit cavity 618, the normal saline of perfusion balloon catheter, or contain the normal saline of liquid radioactive source, or
192Ir microgranule lead all can enter in the conduit from conduit side mouth 613, conduit side mouth stopper rod 614 can complete closed conduit side mouth, the conduit cavity stopper rod 611 that has snaphead can the closes ducts inner chamber, catheter wall 608 adopts the material manufacture that prevents x radiation x, when aqueous radioactive source or microgranular radioactive source enter in the tumor tissues by it, radiation is intercepted, and can not damage surrounding tissue.
3. at the described foley's tube type of claim 1 tumor internal radiotherapy device closely, it is characterized in that the foley's tube type closely mini-radioactive resource that adopts of internal radiotherapy device is the mini-radioactive resource of liquid condition, the mini-radioactive resource of this liquid condition is
125I,
103Pd,
198Man-made isotope radioactive sources such as Au, the radiation gamma-radiation.
4. at the described foley's tube type of claim 1 tumor internal radiotherapy device closely, it is characterized in that, perfusion contains liquid mini-radioactive resource and enters conduit and sacculus and adopt the special device that has protection, finish by automatization's control mode driving peristaltic pump and electromagnetic valve, the perfusion pipeline 202 that peristaltic pump 203 drives directly is connected conduit side mouth 613, containing the radioactive substance liquid filling device is covered by radiological defense cover 204, protective cover 204 is by the sheet metal manufacturing, thickness is 0.5cm～1cm, can the radiation of barrier liquid radioactive source, perfusion pipeline 202 adopts the silicone rubber that contains heavy metal lead or other metal materials with pipe side mouth 613 connecting pipes, surrounding is not leaked when guaranteeing the perfusion fluid radioactive source, other all pipelines, device, container all is placed in the protective cover 204, guarantees that radiationless line leaks environment around.
5. at the described foley's tube type of claim 1 tumor internal radiotherapy device closely, it is characterized in that, the mini-radioactive resource that adopts can also be the radioactive source microgranule of solid state, this microgranule links to each other with back dress internal radiotherapy device by lead, high dose rate (the High Dore Rate HDR) mini-radioactive resource that adopts is a solid 192Ir microgranule, link to each other with lead, computerized control, and adopt a kind of special design to be applied to use the special balloon type conduit of solid, shaped mini-radioactive resource, this conduit increases a conduit exocoel 304, and by conduit exocoel perfusing hole 308 and sacculus 601 traffic, conduit exocoel 304 is used for pouring into normal saline specially, with dilatation balloon, conduit cavity 306 then is used for by solid mini-radioactive resource microgranule 301 and lead 302.
6. at the described foley's tube type of claim 1 tumor internal radiotherapy device closely; it is characterized in that; the balloon type conduit is made up of conduit 602 and the sacculus 601 that sticks to its front end; conduit 602 is by catheter wall 608; conduit outlet 610; conduit cavity 618; sacculus perfusing hole 605; conduit side mouth 613 is formed; conduit cavity is sealed by conduit outlet 610 by the conduit cavity stopper rod 611 that can move freely; conduit cavity stem handles 612 connecting duct stopper rods 611; conduit side mouth stopper rod 614 can closes ducts side mouth 613; sacculus 601 is a double-decker; internal layer sacculus 603 constitutes balloon lumen 609; be used for holding dabbling liquid; outer sacculus 604 is used for shielding, and seals with sacculus fixed layer 606 between sacculus 601 and the conduit 602.
7. at the described foley's tube type of claim 1 tumor internal radiotherapy device closely, it is characterized in that, the tumor brachytherapy device of implantable miniature radioactive source can be widely used in closely internal radiotherapy of various malignant tumor, comprise untreated primary tumor treatment, need treat after the tumor palliative excision of preservation vital tissue, for preventing the preventative local radiotherapy of tumor recurrence, recurrent or transfevent oncotherapy etc.
8. foley's tube type tumor according to claim 1 is the internal radiotherapy device closely, it is characterized in that, conduit outer wall has metal marker thing 619 labellings, clear and definite catheter position when guaranteeing imaging examination and location, the metal marker thing can adopt various metal materials, adopts various known method and labelling.
9. foley's tube type tumor according to claim 1 is the internal radiotherapy device closely, it is characterized in that, the using method of device, can be in operation, to preset the balloon type conduit, and perfusion fluid shape radioactive source and normal saline are retained in the focus, take out the balloon type conduit with simple operation after 5～7 days, also can in operation, preset the tumor bed that the balloon type conduit has excised at tumor tissues, full normal saline in the sacculus, conduit does not hold indwelling external, and every day, twice perfusion fluid shape radioactive source was extracted out after 6～10 minutes, perhaps being used for the tract internal radiotherapy, can also be the closely internal radiotherapy of inserting conduit in in-vitro percutaneous puncture
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2003101080895A CN1537648A (en) | 2003-10-22 | 2003-10-22 | Saccule catheter type tumour close internal radiation therapy device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2003101080895A CN1537648A (en) | 2003-10-22 | 2003-10-22 | Saccule catheter type tumour close internal radiation therapy device |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1537648A true CN1537648A (en) | 2004-10-20 |
Family
ID=34334497
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNA2003101080895A Pending CN1537648A (en) | 2003-10-22 | 2003-10-22 | Saccule catheter type tumour close internal radiation therapy device |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1537648A (en) |
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105555361A (en) * | 2013-09-19 | 2016-05-04 | 皇家飞利浦有限公司 | High-dose rate brachytherapy system |
| CN105749415A (en) * | 2016-02-03 | 2016-07-13 | 陈挺松 | Balloon catheter applied to portal vein |
| CN109331349A (en) * | 2018-11-20 | 2019-02-15 | 北京大学第医院 | The filling device of radiotherapy tracer after Breast reservation |
| CN110314274A (en) * | 2019-06-27 | 2019-10-11 | 原子高科股份有限公司 | A kind of sacculus carrying radioactive particle |
| CN112007286A (en) * | 2020-08-28 | 2020-12-01 | 朱格红 | Method for manufacturing gynecological tumor after-loading operation auxiliary device |
| CN113018697A (en) * | 2021-02-01 | 2021-06-25 | 山东第一医科大学附属肿瘤医院(山东省肿瘤防治研究院、山东省肿瘤医院) | Radiotherapy protector and protection device |
| CN113368409A (en) * | 2021-05-07 | 2021-09-10 | 西安国际医学中心有限公司 | Radiation therapy protective equipment in gynecological tumor cavity |
| CN115715852A (en) * | 2022-11-18 | 2023-02-28 | 哈尔滨理工大学 | Monte Carlo simulation-based bag structure optimization method |
-
2003
- 2003-10-22 CN CNA2003101080895A patent/CN1537648A/en active Pending
Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105555361A (en) * | 2013-09-19 | 2016-05-04 | 皇家飞利浦有限公司 | High-dose rate brachytherapy system |
| CN105555361B (en) * | 2013-09-19 | 2018-12-18 | 皇家飞利浦有限公司 | High dose rate plesioradiotherapy system |
| US10279194B2 (en) | 2013-09-19 | 2019-05-07 | Koninklijke Philips N.V. | High-dose rate brachytherapy system |
| CN105749415A (en) * | 2016-02-03 | 2016-07-13 | 陈挺松 | Balloon catheter applied to portal vein |
| CN109331349A (en) * | 2018-11-20 | 2019-02-15 | 北京大学第医院 | The filling device of radiotherapy tracer after Breast reservation |
| CN110314274A (en) * | 2019-06-27 | 2019-10-11 | 原子高科股份有限公司 | A kind of sacculus carrying radioactive particle |
| CN112007286A (en) * | 2020-08-28 | 2020-12-01 | 朱格红 | Method for manufacturing gynecological tumor after-loading operation auxiliary device |
| CN112007286B (en) * | 2020-08-28 | 2022-09-27 | 朱格红 | Method for manufacturing gynecological tumor after-loading operation auxiliary device |
| CN113018697A (en) * | 2021-02-01 | 2021-06-25 | 山东第一医科大学附属肿瘤医院(山东省肿瘤防治研究院、山东省肿瘤医院) | Radiotherapy protector and protection device |
| CN113368409A (en) * | 2021-05-07 | 2021-09-10 | 西安国际医学中心有限公司 | Radiation therapy protective equipment in gynecological tumor cavity |
| CN115715852A (en) * | 2022-11-18 | 2023-02-28 | 哈尔滨理工大学 | Monte Carlo simulation-based bag structure optimization method |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP3505622B2 (en) | Tumor treatment device | |
| EP1239920B1 (en) | Asymmetric radiation dosing apparatus and method | |
| CA2504965C (en) | Vacuum device and method for treating tissue adjacent a body cavity | |
| US20060020156A1 (en) | Therapeutic device | |
| US4763642A (en) | Intracavitational brachytherapy | |
| US20050240073A1 (en) | Devices and methods to conform and treat body cavities | |
| US20030012325A1 (en) | Mixture containing rare earth and the use thereof | |
| US20050015049A1 (en) | Temporary tissue spacer and pretreatment balloon | |
| US20090312593A1 (en) | Radioactive Device for treatment of a Tumor | |
| JPH10507951A (en) | Vascular treatment method and apparatus | |
| KR19990053747A (en) | Radioactive baluns used in balloon ware and manufacturing method thereof | |
| CN1537646A (en) | Tumour local comprehensive therepy method and device | |
| CN105407955B (en) | The device and method for conveying drug | |
| CN1537648A (en) | Saccule catheter type tumour close internal radiation therapy device | |
| US20120108882A1 (en) | Brachytherapy Devices and Related Methods Providing Bioaborbability and/or Asymmetric Irradiation | |
| CN1537647A (en) | Tumour close internal rediation therapy device presetted in operation | |
| CA2617926A1 (en) | Tumescent skin spacing method | |
| KR20060107780A (en) | Drug eluting brachytherapy methods and apparatus | |
| EP1680188B1 (en) | Brachytherapy apparatus | |
| CN201006055Y (en) | Biliary tract supporting inside and outside conduction and continuous intracavity near-range radiotheraphy combination units | |
| JP2002500072A (en) | Method and apparatus for disinfecting a subcutaneous implant device | |
| Chan et al. | Carcinoma of the prostate. Its treatment by a combination of radioactive gold‐grain implant and external irradiation | |
| Harada et al. | Remote afterloading transurethral radiotherapy for prostatic cancer | |
| CN209451136U (en) | It is a kind of for carrying the conduit of radioactive particle and drug | |
| CN109173092A (en) | It is a kind of easily from the Inner irradiation device taken out in vivo |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |