CN110314274A - A kind of sacculus carrying radioactive particle - Google Patents

A kind of sacculus carrying radioactive particle Download PDF

Info

Publication number
CN110314274A
CN110314274A CN201910570998.1A CN201910570998A CN110314274A CN 110314274 A CN110314274 A CN 110314274A CN 201910570998 A CN201910570998 A CN 201910570998A CN 110314274 A CN110314274 A CN 110314274A
Authority
CN
China
Prior art keywords
sacculus
radioactive particle
carrying
particle
radioactive
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201910570998.1A
Other languages
Chinese (zh)
Inventor
张文辉
高惠波
李忠勇
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ATOM HIGH TECH Co Ltd
Original Assignee
ATOM HIGH TECH Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ATOM HIGH TECH Co Ltd filed Critical ATOM HIGH TECH Co Ltd
Priority to CN201910570998.1A priority Critical patent/CN110314274A/en
Publication of CN110314274A publication Critical patent/CN110314274A/en
Pending legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00Radiation therapy
    • A61N5/10X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A61N5/1001X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy using radiation sources introduced into or applied onto the body; brachytherapy
    • A61N5/1002Intraluminal radiation therapy
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00Radiation therapy
    • A61N5/10X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A61N5/1001X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy using radiation sources introduced into or applied onto the body; brachytherapy
    • A61N5/1007Arrangements or means for the introduction of sources into the body
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00Radiation therapy
    • A61N5/10X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A61N5/1001X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy using radiation sources introduced into or applied onto the body; brachytherapy
    • A61N5/1014Intracavitary radiation therapy
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00Radiation therapy
    • A61N5/10X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A61N5/1001X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy using radiation sources introduced into or applied onto the body; brachytherapy
    • A61N5/1028X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy using radiation sources introduced into or applied onto the body; brachytherapy using radiation sources applied onto the body

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Pathology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Radiation-Therapy Devices (AREA)

Abstract

The invention discloses a kind of sacculus for carrying radioactive particle, sacculus is the sacculus used in body cavities or internal organs, it is implanted into Shi Weiwei expanded state, the balloon dilatation after the air of certain pressure or water are full, make balloon wall close to lesions position, fixed, support is played, expands, filling, be isolated, the function of embolism body cavities and internal organs, sacculus inner surface carries radioactive particle, and there is protrusion in sacculus outer surface.Sacculus provided by the present invention can carry out the close-range treatment of radioactive particle, simplify the implant surgery process of radioactive particle, saved operation cost, improve the safety for the treatment of.

Description

A kind of sacculus carrying radioactive particle
Technical field
The present invention relates to a kind of radioactivity close-range treatment fixture technology fields, and in particular to a kind of carrying radioactive particle Sacculus.
Background technique
Malignant tumour is always to threaten the major disease of human health, closely control between tissue using radioactive particle Treating tumour is the new technology that recent decades grow up.Radioactive particle is a kind of small radioactive sources, and the radioactive source is radioactivity Isotope is in titanium tube, and both ends laser or electron beam technology weld to form sealed source, and size is generally outer diameter 0.8mm, Length is 4.5mm.The common nucleic of radioactive particle has192Ir、198Au、169Y、131Cs、103Pd and125I etc., especially103Pd With125I.Radioactive particle is implanted directly into lesion by close-range treatment, and short distance prolonged exposure destroys the DNA double of neoplastic cell nuclei Key, lethal or sub- lethal tumor cell, makes it lose replication capacity, to reach therapeutic purposes, while isotope ray used Energy is lower, and ray can effectively be avoided to damage normal tissue on the way in irradiation.
But, the entity being mainly used for radioactive particle suitable for radioactive prospecting instrument operation at present clinically Tumor, and for the important organ, body of gland, cavity position of some unsuitable punctures, because radioactive particle can not be in lesions position It is fixed, it is not just available radioactive particle and carries out the organ in close-range treatment, especially human body with larger cavity, such as stomach The internal organs position such as portion, uterus, lesions position are located on cavity wall, and to carry out the treatment of radioactive particle at this position, simultaneously The normal physiological function of internal organs can't be influenced, almost becomes impossible mission, this seriously hinders radioactivity grain The application range of son.
Chinese patent " tumor by local comprehensive treatment and device " (publication number: CN 1537646A, publication date: 2004 On October 20, in) a kind of a variety of combination therapy means for being directed to lesions position based on air bag are provided, which use liquid Body radioactive source perfusion balloon catheter is used for the radioactivity close-range treatment of tumour.But this mode be generally only suitable for it is interim short-term Treatment, long-term or permanent sacculus implanted treatment can greatly increase the risk of sacculus rupture liquid radioactive source leakage, and liquid Body radioactive source is difficult to realize the accurate effective distribution of radioactive dosage, and most radioactive ray therapeutic dose is present in ball Intracapsular portion is absorbed by normal tissue.
Summary of the invention
In view of the deficiencies in the prior art, the purpose of the present invention is to provide a kind of balls for carrying radioactive particle Capsule, allows the close-range treatment for having the internal organs of larger cavity body structure to carry out radioactive particle in human body, extends radioactivity grain The close-range treatment application range of son.
To achieve the above object, The technical solution adopted by the invention is as follows:
A kind of sacculus carrying radioactive particle, the sacculus are the sacculus used in body cavities or internal organs, when implantation For non-expanded state, the balloon dilatation after the air of certain pressure or water are full, play fixed, support, expand, filling, every From, the function of embolism body cavities and internal organs, make balloon wall close to lesions position, sacculus inner surface carries radioactive particle, There is protrusion in sacculus outer surface.
Further, the sacculus is made of medical elastic material, and same as the sacculus material of the protrusion use is made, Or it is made using other biological compatibility material.
Further, the sacculus is spherical, stick or other are adapted to the special shape of implantation position.
Further, the sacculus is sacculus in alimentary canal, uterine cavity sacculus, intravaginal sacculus, biliary tract sacculus, glomus One of capsule, intraperitoneal sacculus, urethra sacculus.
Further, the carrying method is the inner surface that radioactive particle is adhered to balloon wall with adhesive.
Further, the carrying method is the card slot in sacculus inner surface production radioactive particle, will radiation when use Property particle be inserted into card slot.
Further, the radioactive particle is dispersed evenly to entire sacculus inner surface.
Further, it is distributed according to specific tumour cell, by radioactive particle integrated distribution in close to lesions position Sacculus inner surface, accurately adjusting balloon position in implantation makes radioactive particle close to lesions position.
Further, the species type of the radioactive particle is192Ir、198Au、169Y、131Cs、103Pd and125One kind of I Or it is a variety of.
Further, the sacculus for carrying radioactive particle takes out after completing therapeutic purposes or is not influencing human body just It is chronically implanted in the case where normal function.
The beneficial effects of the present invention are:
1, the use scope for extending radioactive particle can not pass through the disease of puncture means immobilization of radioactive particle to some Radioactive particle close to lesion and is played low coverage by mechanisms such as the fixation of sacculus, support, expansion, fillings by stove position From therapeutic effect;
2, the protrusion of balloon surface can fix the balloon position after expanding, and radiate the radioactive particle of sacculus inner surface Dosage distribution is fixed, and is reached the treatment to lesions position and is reduced the influence of normal tissue to greatest extent;
3, without puncturing to lesions position, radioactive particle is positioned at lesion portion merely by sacculus is full Position, on the normal physiological function of the tissue of lesions position and internal organs substantially without influence;
4, the implant surgery process of radioactive particle is simplified, the sacculus of more radioactive particles of a carrying is implanted into and reaches Operation can be completed to full stationary state and the operation of existing clinical radiation seeds implanted is needed through puncture means by grain The mode of implantation radiation particle is compared, and operating time is greatly saved and reduces the agent that medical staff receives radioactive radiation Amount can also reduce financial burden and operation wound that operation cost mitigates patient;
5, Therapeutic safety is high, even if sacculus ruptures after the implantation, radioactive particle migration will not occur, less The diffusion of radioactive substance can occur.
Detailed description of the invention
Fig. 1 is the diagrammatic cross-section of the sacculus of the carrying radioactive particle of the embodiment of the present invention one;
Fig. 2 is the diagrammatic cross-section of the sacculus of the carrying radioactive particle of the embodiment of the present invention two;
Fig. 3 is the diagrammatic cross-section of the sacculus of the carrying radioactive particle of the embodiment of the present invention three;
Fig. 4 is the diagrammatic cross-section of the sacculus of the carrying radioactive particle of the embodiment of the present invention four;
Wherein:
1- sacculus;2- radioactive particle;3- is close to the region of lesions position;4- card slot;5- protrusion.
Specific embodiment
The present invention is described in further detail with specific embodiment with reference to the accompanying drawings of the specification.
Sacculus 1 is the sacculus used in body cavities or internal organs, is implanted into Shi Weiwei expanded state, the air through certain pressure Or the full rear balloon dilatation of water, fixed, support is played, expands, filling, be isolated, the function of embolism body cavities and internal organs, is made Balloon wall is made close to lesions position, sacculus of medical elastic material, including but not limited to sacculus in alimentary canal, uterine cavity ball Capsule, intravaginal sacculus, biliary tract sacculus, blood saccule, intraperitoneal sacculus, urethra sacculus.
The sacculus can be spherical, stick or other are adapted to the special shape of implantation position;Outside the sacculus Surface is equipped with protrusion;The inner surface of the sacculus carries radioactive particle.
Embodiment one:
As shown in Figure 1, the method that sacculus 1 carries radioactive particle is that radioactive particle 2 is adhered to sacculus with adhesive The inner surface of wall, radioactive particle 2 intersperse among entire sacculus inner surface.The outer surface of the sacculus is equipped with protrusion 5, the protrusion 5 uses material identical with sacculus is made, or other biological compatibility material is used alone and is made, after balloon dilatation, protrusion 5 Sacculus can be preferably fixed on treatment position, sacculus is prevented to be subjected to displacement.The sacculus for carrying radioactive particle can be complete It at being taken out after therapeutic purposes, can also be chronically implanted in the case where not influencing human normal function, the sacculus after taking-up can be with It is re-used after replacement radioactive particle.The species type of radioactive particle includes192Ir、198Au、169Y、131Cs、103Pd With125At least one of I.
Embodiment two:
As shown in Fig. 2, the method that sacculus 1 carries radioactive particle is that radioactive particle 2 is adhered to sacculus with adhesive The inner surface of wall.Meanwhile being distributed according to specific tumour cell, by 2 integrated distribution of radioactive particle in close to lesions position Region 3, accurately adjusting balloon position in implantation makes radioactive particle 2 close to lesions position.The outer surface of the sacculus is equipped with Protrusion 5, raised 5 use material identical with sacculus is made, or exclusive use other biological compatibility material is made, ball After capsule expands, sacculus can be preferably fixed on treatment position by protrusion 5, and sacculus is prevented to be subjected to displacement.Carry radioactive particle Sacculus can be taken out after completing therapeutic purposes, can also be chronically implanted, take in the case where not influencing human normal function Sacculus after out re-uses after can replacing radioactive particle.The species type of radioactive particle includes192Ir、198Au、169Y、131Cs、103Pd and125At least one of I.
Embodiment three:
As shown in figure 3, the method that sacculus 1 carries radioactive particle is the card slot in sacculus inner surface production radioactive particle 4, radioactive particle is inserted into card slot 4 when use.Card slot 4 is dispersed evenly to entire sacculus inner surface.The outer surface of the sacculus Equipped with protrusion 5, raised 5 use material identical with sacculus is made, or exclusive use other biological compatibility material system At after balloon dilatation, sacculus can be preferably fixed on treatment position by protrusion 5, and sacculus is prevented to be subjected to displacement.Carry radioactivity The sacculus of particle can take out after completing therapeutic purposes, can also plant for a long time in the case where not influencing human normal function Enter, the sacculus after taking-up re-uses after can replacing radioactive particle.The species type of radioactive particle includes192Ir、198Au、169Y、131Cs、103Pd and125At least one of I.
Example IV:
As shown in figure 4, the method that sacculus 1 carries radioactive particle is the card slot in sacculus inner surface production radioactive particle 4, radioactive particle is inserted into card slot 4 when use.It is distributed according to specific tumour cell, by 4 integrated distribution of card slot in close to disease The region 3 at stove position, accurately adjusting balloon position in implantation makes radioactive particle close to lesions position.The appearance of the sacculus Face is equipped with protrusion 5, and raised 5 use material identical with sacculus is made, or exclusive use other biological compatibility material It is made, after balloon dilatation, sacculus can be preferably fixed on treatment position by protrusion 5, and sacculus is prevented to be subjected to displacement.Carry radiation The sacculus of property particle can take out after completing therapeutic purposes, can also plant for a long time in the case where not influencing human normal function Enter, the sacculus after taking-up re-uses after can replacing radioactive particle.The species type of the radioactive particle includes192Ir、198Au、169Y、131Cs、103Pd and125At least one of I.
Obviously, various changes and modifications can be made to the invention without departing from essence of the invention by those skilled in the art Mind and range.In this way, if these modifications and changes of the present invention belongs to the range of the claims in the present invention and its equivalent technology Within, then the present invention is also intended to include these modifications and variations.

Claims (10)

1. a kind of sacculus for carrying radioactive particle, which is characterized in that the sacculus is the ball used in body cavities or internal organs Capsule is implanted into Shi Weiwei expanded state, and the balloon dilatation after the air of certain pressure or water are full makes balloon wall close to lesion portion , fixed, support is played, expands, filling, be isolated, the function of embolism body cavities and internal organs, sacculus inner surface carries radiation Property particle, there is protrusion in sacculus outer surface.
2. a kind of sacculus as described in claim 1 for carrying radioactive particle, which is characterized in that the sacculus is by medical elastic Material is made, and identical with the sacculus material of the protrusion use is made, or is made using other biological compatibility material.
3. a kind of as claimed in claim 1 or 2 sacculus for carrying radioactive particle, which is characterized in that the sacculus be it is spherical, Stick or other be adapted to the special shape of implantation position.
4. a kind of sacculus as claimed in claim 1 or 2 for carrying radioactive particle, which is characterized in that the sacculus is digestion Sacculus in road, uterine cavity sacculus, intravaginal sacculus, biliary tract sacculus, one of blood saccule, intraperitoneal sacculus, urethra sacculus.
5. a kind of sacculus as described in claim 1 for carrying radioactive particle, which is characterized in that the carrying method is with viscous Radioactive particle is adhered to the inner surface of balloon wall by mixture.
6. a kind of sacculus as described in claim 1 for carrying radioactive particle, which is characterized in that the carrying method is in ball Radioactive particle is inserted into card slot when use by the card slot of intracapsular surface production radioactive particle.
7. a kind of such as the sacculus described in claim 5 or 6 for carrying radioactive particle, which is characterized in that the radioactive particle It is dispersed evenly to entire sacculus inner surface.
8. a kind of such as the sacculus described in claim 5 or 6 for carrying radioactive particle, which is characterized in that according to specific tumour Cell distribution accurately adjusts sacculus in implantation by radioactive particle integrated distribution in the sacculus inner surface close to lesions position Position makes radioactive particle close to lesions position.
9. a kind of such as the sacculus described in claim 5 or 6 for carrying radioactive particle, which is characterized in that the radioactive particle Species type be192Ir、198Au、169Y、131Cs、103Pd and125One of I or a variety of.
10. a kind of such as the sacculus described in claim 5 or 6 for carrying radioactive particle, which is characterized in that carry radioactive particle Sacculus take out after completing therapeutic purposes or be chronically implanted in the case where not influencing human normal function.
CN201910570998.1A 2019-06-27 2019-06-27 A kind of sacculus carrying radioactive particle Pending CN110314274A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201910570998.1A CN110314274A (en) 2019-06-27 2019-06-27 A kind of sacculus carrying radioactive particle

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201910570998.1A CN110314274A (en) 2019-06-27 2019-06-27 A kind of sacculus carrying radioactive particle

Publications (1)

Publication Number Publication Date
CN110314274A true CN110314274A (en) 2019-10-11

Family

ID=68120618

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201910570998.1A Pending CN110314274A (en) 2019-06-27 2019-06-27 A kind of sacculus carrying radioactive particle

Country Status (1)

Country Link
CN (1) CN110314274A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112472995A (en) * 2020-12-07 2021-03-12 党松松 Silicone stent with radioactive particles for department of respiration

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1537647A (en) * 2003-10-22 2004-10-20 高春平 Tumour close internal rediation therapy device presetted in operation
CN1537648A (en) * 2003-10-22 2004-10-20 高春平 Saccule catheter type tumour close internal radiation therapy device
CN101631590A (en) * 2007-03-12 2010-01-20 赛诺克斯有限公司 Radiation catheter with multilayered balloon
CN201798827U (en) * 2010-09-28 2011-04-20 上海交通大学医学院附属瑞金医院卢湾分院 Biliary tract internal exposure support
CN208823772U (en) * 2017-09-18 2019-05-07 王娟 It is a kind of can short-term interpolation treatment tumour sacculus particle chain
CN211410672U (en) * 2019-06-27 2020-09-04 原子高科股份有限公司 Balloon carrying radioactive particles

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1537647A (en) * 2003-10-22 2004-10-20 高春平 Tumour close internal rediation therapy device presetted in operation
CN1537648A (en) * 2003-10-22 2004-10-20 高春平 Saccule catheter type tumour close internal radiation therapy device
CN101631590A (en) * 2007-03-12 2010-01-20 赛诺克斯有限公司 Radiation catheter with multilayered balloon
CN201798827U (en) * 2010-09-28 2011-04-20 上海交通大学医学院附属瑞金医院卢湾分院 Biliary tract internal exposure support
CN208823772U (en) * 2017-09-18 2019-05-07 王娟 It is a kind of can short-term interpolation treatment tumour sacculus particle chain
CN211410672U (en) * 2019-06-27 2020-09-04 原子高科股份有限公司 Balloon carrying radioactive particles

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112472995A (en) * 2020-12-07 2021-03-12 党松松 Silicone stent with radioactive particles for department of respiration
CN112472995B (en) * 2020-12-07 2022-08-12 杨云伟 Silicone stent with radioactive particles for department of respiration

Similar Documents

Publication Publication Date Title
US6413204B1 (en) Interstitial brachytherapy apparatus and method for treatment of proliferative tissue diseases
US8680498B2 (en) Method of utilizing an implant in a human breast
EP0934094B1 (en) Inflatable devices for tumor treatment
US9468519B2 (en) Methods and systems for breast reconstruction
JP4880593B2 (en) Tissue deviation or separation device
US7413539B2 (en) Treatment of a body cavity
ES2263515T3 (en) APPLIANCE AND ASYMMETRIC RADIATION DOSAGE PROCEDURE.
US20060020156A1 (en) Therapeutic device
ES2424348T3 (en) Loads and methods to move tissues to improve radiological results
US9283402B2 (en) Apparatus and method for providing a double balloon breast brachytherapy device
WO1998015315A9 (en) Inflatable devices for tumor treatment
US20090312593A1 (en) Radioactive Device for treatment of a Tumor
JP2006517127A (en) Seed spacer string end cap for brachytherapy
AU2004291072B2 (en) Drug eluting brachytherapy methods and apparatus
CN110314274A (en) A kind of sacculus carrying radioactive particle
CN207822261U (en) A kind of radioactive particle chain connected using high molecular polymer connecting tube
CN211410672U (en) Balloon carrying radioactive particles
US20150306422A1 (en) Apparatus for brachytherapy
US8303477B2 (en) Fluid radiation shield for brachytherapy
US20100094075A1 (en) Expandable medical devices with reinforced elastomeric members and methods employing the same
CN117064604A (en) Human body cavity inner support with radioactivity
CN107233662A (en) A kind of radioactive particle chain of use high molecular polymer connecting tube connection

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination