CN1537607A - Traditional Chinese medicine for removing heat from liver to reduce transaminase - Google Patents

Abstract

A Chinese medicine in the form of honeyed pills for treating hepatitis B, hypertransaminase caused by hepatitis B, liver damage, icterus, and heptosplenomegaly is prepared from 14 Chinese-medicinal materials including rehmannia root, phellodendron bark, astragalus root, liquorice root, etc through grinding, sieving, mixing and shaping honeyed pills.

Description

The Chinese medicine of enzyme falls in a kind of liver heat removing

Technical field: the present invention relates to Chinese medicine, particularly have removing liver heat and toxic substances, the liver protecting and ALT lowering, nourishing the blood and yin, dampness removing jaundice eliminating merit to can Chinese medicine.

Background technology: the Western medicine of controlling the hepatitis B disease at present generally all has side effect, effect also not remarkable, and the Chinese medicine of treatment hepatitis B disease is of a great variety but the effect of curing the disease is bad, cure the symptoms, not the disease, and addressing this problem becomes urgent need.

The content of invention: overcome the deficiency that prior art exists, proposes a kind ofly to treat that hepatitis B, hepatitis B transaminase's height, bitter taste yellowish urine, night sweat are weak, the Chinese medicine of dizziness and tinnitus, hectic fever low grade fever, hepatic injury, hepatosplenomegaly, jaundice due to damp-heat, disease such as thin how sleepy.This Chinese medicine is made by the following weight proportion raw material: Radix Rehmanniae 40-60 part, Herba Euphorbiae Helioscopiae 10-20 part, Poria 10-20 part, Rhizoma Anemarrhenae 8-16 part, Cortex Phellodendri 8-12 part, Fructus Forsythiae 8-16 part, Fructus Schisandrae Chinensis 10-20 part, Radix Scrophulariae 8-16 part, Radix Berberidis 14-22 part, Radix Sophorae Flavescentis 8-12 part, Radix Astragali 14-22 part, Radix Glycyrrhizae 6-10 part, Radix Isatidis 6-10 part, Radix Gentianae 8-12 part.Its production method is: the medicine of just respectively distinguishing the flavor of grinds to smalls together, sieves, mixes to spare and make honeyed pill.Therefore Chinese medicine of the present invention have hepatoprotective effect owing to contain the Radix Rehmanniae, Herba Euphorbiae Helioscopiae, Poria can protect the liver kidney tonifying, blood sugar lowering, separate liver-heat, Cortex Phellodendri has inhibitory action to multiple virus, and Fructus Forsythiae can anti-hepatic injury and multiple virus, the Fructus Schisandrae Chinensis transaminase lowering, Radix Berberidis can antiviral, have hemostatic effect, Radix Sophorae Flavescentis to contain multiple alkaloid, go into the heart can make decreased heart rate, and going into lung can cough-relieving, go into kidney can dampness removing diuresis, go into the liver heat drop transaminase that dehumidifies that can detoxify, help with Radix Scrophulariae then can in and toxicity; The Radix Astragali can enhancing immunity, protect the liver QI invigorating, Radix Isatidis anti-hepatitis virus and influenza virus, and Radix Gentianae can promote gastric secretion.The result of above-mentioned every medicine comprehensive function make Chinese medicine of the present invention have removing liver heat and toxic substances, the liver protecting and ALT lowering, nourishing the blood and yin, dampness removing jaundice eliminating, function.

The specific embodiment: this Chinese medicine is made by the following weight proportion raw material: Radix Rehmanniae 600g, Herba Euphorbiae Helioscopiae 200g, Poria 200g, Rhizoma Anemarrhenae 160g, Cortex Phellodendri 120g, Fructus Forsythiae 160g, Fructus Schisandrae Chinensis 200g, Radix Scrophulariae 160g, Radix Berberidis 140g, Radix Sophorae Flavescentis 120g, Radix Astragali 220g, Radix Glycyrrhizae 100g, Radix Isatidis 100g, Radix Gentianae 120g.Its production method is: the medicine of just respectively distinguishing the flavor of grinds to smalls together, sieves, mixes to spare and make honeyed pill.

Second embodiment of the present invention, this Chinese medicine is made by the following weight proportion raw material: Radix Rehmanniae 400g, Herba Euphorbiae Helioscopiae 100g, Poria 100g, Rhizoma Anemarrhenae 80g, Cortex Phellodendri 80g, Fructus Forsythiae 80g, Fructus Schisandrae Chinensis 100g, Radix Scrophulariae 80g, Radix Berberidis 220g, Radix Ginseng 80g, Radix Astragali 140g, Radix Glycyrrhizae 60g, Radix Isatidis 60g, Radix Gentianae 80g.Its production method is: the medicine of just respectively distinguishing the flavor of grinds to smalls together, sieves, mixes to spare and make honeyed pill.

The usage of this medicine and consumption: ante cibum warm boiled water, three times on the one, the each 10-15 of adult gram, children's reduces by half.

In order to estimate the clinical medicine safety of Chinese medicine of the present invention, it has been carried out toxicity test research, be reported as follows:

1. be subjected to test product: Chinese medicine every day 3 times of enzyme, each 10-15 gram fall in a kind of liver heat removing.

2. experimental animal: the white mice of Kunming kind, body weight 18-22 gram, male and female dual-purpose.

3. the preparation of dosage and test drug: get Chinese medicine 45 grams that enzyme falls in a kind of liver heat removing, put and add the 100.0ml distilled water in the mortar and be uniformly dispersed, making concentration is 24% solution.Administering mode is a gastric infusion.

Five, the mensuration of median lethal dose(LD 50)

Get 9 of mices, divide three groups, but fail to find out the dosage of 100% animal dead.

Select 50 of the healthy mices of body weight 20 ± 2g for use, male and female half and half are divided into five groups at random, and are once oral

Gastric infusion, dosage are by geometric progression, and maximum dose level calculates with the maximum volume that can accept.Observed 7 days none death as a result after the administration.

Six, mtd test

Select 20 of healthy mices, male and female half and half, normally raise 1 after, administration is 3 times in 24 hours, 5 hours blanking times, total administration volume 120ml/kg observed 7 continuously, did not see untoward reaction and death condition, can think the oral avirulence of this medicine.

The maximum tolerated dose multiple is calculated as follows:

$=\frac{0.8\×3\×24\%}{20}\×\frac{60000}{6\×3\×0.4}$

Calculate if obey 45 grams every day by the adult, the result is 240 times of normal clinical dosage, illustrates that a kind of liver heat removing falls the Chinese medicine of enzyme and have safety.

The Chinese medicine clinical summary of enzyme falls in a kind of liver heat removing

One group to the statistics in the clinical liver disease observations.

This organizes 5% case for observing the patient of treatment.Man's 43 examples wherein, women 16 examples, age 40-50 year 10 examples, 51-60 year 30 examples, 19 examples more than 61 years old, hepatitis B, hepatitis B transaminase's height, 17 examples, bitter taste yellowish urine, night sweat are weak, dizziness and tinnitus, hectic fever low grade fever 6 examples, hepatic injury, hepatosplenomegaly 33 examples, jaundice due to damp-heat, thin how sleepy 3 examples.Wherein Therapeutic Method is the patient to be divided into two groups at random, and 39 examples are organized in treatment, obeys capsule of the present invention, every day three times, and each 1 ball, 60 days is a course of treatment.Matched group 20 examples are taken other medicine, and 60 days is a course of treatment, withdraws other medicines before the administration, all do inspection before and after the treatment, and the result shows that the treatment group effective percentage of taking Chinese medicine of the present invention is 98%, and matched group does not have obvious effects.

Claims (2)

1, the Chinese medicine of enzyme falls in a kind of liver heat removing, it is characterized in that: this Chinese medicine is made by the following weight proportion raw material: Radix Rehmanniae 40-60 part, Herba Euphorbiae Helioscopiae 10-20 part, Poria 10-20 part, Rhizoma Anemarrhenae 8-16 part, Cortex Phellodendri 8-12 part, Fructus Forsythiae 8-16 part, Fructus Schisandrae Chinensis 10-20 part, Radix Scrophulariae 8-16 part, Radix Berberidis 14-22 part, Radix Sophorae Flavescentis 8-12 part, Radix Astragali 14-22 part, Radix Glycyrrhizae 6-10 part, Radix Isatidis 6-10 part, Radix Gentianae 8-12 part.

2, want 1 described liver heat removing to fall the Chinese medicine of enzyme as right, its production method is: the medicine of just respectively distinguishing the flavor of grinds to smalls together, sieves, mixes to spare and make honeyed pill.