CN1535582A - 杀微生物的组合物 - Google Patents
杀微生物的组合物 Download PDFInfo
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- CN1535582A CN1535582A CNA2004100333487A CN200410033348A CN1535582A CN 1535582 A CN1535582 A CN 1535582A CN A2004100333487 A CNA2004100333487 A CN A2004100333487A CN 200410033348 A CN200410033348 A CN 200410033348A CN 1535582 A CN1535582 A CN 1535582A
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- carbamate
- isothiazoline
- triazine
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- 230000003641 microbiacidal effect Effects 0.000 claims abstract description 44
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- KXDHJXZQYSOELW-UHFFFAOYSA-M Carbamate Chemical compound NC([O-])=O KXDHJXZQYSOELW-UHFFFAOYSA-M 0.000 claims abstract description 10
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims abstract description 10
- 239000011593 sulfur Substances 0.000 claims abstract description 10
- 229910052717 sulfur Inorganic materials 0.000 claims abstract description 10
- -1 3-iodo-2-propynyl Chemical group 0.000 claims description 13
- 150000001412 amines Chemical class 0.000 claims description 11
- 125000000304 alkynyl group Chemical group 0.000 claims description 7
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- 229910052740 iodine Inorganic materials 0.000 claims 1
- 239000011630 iodine Substances 0.000 claims 1
- QVCOXWYMPCBIMH-UHFFFAOYSA-N prop-2-ynyl carbamate Chemical compound NC(=O)OCC#C QVCOXWYMPCBIMH-UHFFFAOYSA-N 0.000 claims 1
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- 239000002855 microbicide agent Substances 0.000 description 21
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- FEGQKRBINKODEF-UHFFFAOYSA-N 1,2-thiazol-3-one Chemical compound OC=1C=CSN=1.O=C1C=CSN1 FEGQKRBINKODEF-UHFFFAOYSA-N 0.000 description 2
- ZWEHNKRNPOVVGH-UHFFFAOYSA-N 2-Butanone Chemical compound CCC(C)=O ZWEHNKRNPOVVGH-UHFFFAOYSA-N 0.000 description 2
- WYVVKGNFXHOCQV-UHFFFAOYSA-N 3-iodoprop-2-yn-1-yl butylcarbamate Chemical group CCCCNC(=O)OCC#CI WYVVKGNFXHOCQV-UHFFFAOYSA-N 0.000 description 2
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- 239000007787 solid Substances 0.000 description 2
- KDYFGRWQOYBRFD-UHFFFAOYSA-N succinic acid Chemical compound OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 description 2
- 239000002562 thickening agent Substances 0.000 description 2
- 230000001988 toxicity Effects 0.000 description 2
- 231100000419 toxicity Toxicity 0.000 description 2
- URAYPUMNDPQOKB-UHFFFAOYSA-N triacetin Chemical compound CC(=O)OCC(OC(C)=O)COC(C)=O URAYPUMNDPQOKB-UHFFFAOYSA-N 0.000 description 2
- 238000005406 washing Methods 0.000 description 2
- VKZRWSNIWNFCIQ-WDSKDSINSA-N (2s)-2-[2-[[(1s)-1,2-dicarboxyethyl]amino]ethylamino]butanedioic acid Chemical compound OC(=O)C[C@@H](C(O)=O)NCCN[C@H](C(O)=O)CC(O)=O VKZRWSNIWNFCIQ-WDSKDSINSA-N 0.000 description 1
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 description 1
- JLHMJWHSBYZWJJ-UHFFFAOYSA-N 1,2-thiazole 1-oxide Chemical group O=S1C=CC=N1 JLHMJWHSBYZWJJ-UHFFFAOYSA-N 0.000 description 1
- OAAZUWWNSYWWHG-UHFFFAOYSA-N 1-phenoxypropan-1-ol Chemical compound CCC(O)OC1=CC=CC=C1 OAAZUWWNSYWWHG-UHFFFAOYSA-N 0.000 description 1
- WRMNZCZEMHIOCP-UHFFFAOYSA-N 2-phenylethanol Chemical compound OCCC1=CC=CC=C1 WRMNZCZEMHIOCP-UHFFFAOYSA-N 0.000 description 1
- 229940099451 3-iodo-2-propynylbutylcarbamate Drugs 0.000 description 1
- PORQOHRXAJJKGK-UHFFFAOYSA-N 4,5-dichloro-2-n-octyl-3(2H)-isothiazolone Chemical compound CCCCCCCCN1SC(Cl)=C(Cl)C1=O PORQOHRXAJJKGK-UHFFFAOYSA-N 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- DKPFZGUDAPQIHT-UHFFFAOYSA-N Butyl acetate Natural products CCCCOC(C)=O DKPFZGUDAPQIHT-UHFFFAOYSA-N 0.000 description 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
- 241000195493 Cryptophyta Species 0.000 description 1
- 229920000858 Cyclodextrin Polymers 0.000 description 1
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 1
- 241000233866 Fungi Species 0.000 description 1
- 239000002202 Polyethylene glycol Substances 0.000 description 1
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- 240000004808 Saccharomyces cerevisiae Species 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
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- 125000004429 atom Chemical group 0.000 description 1
- 239000003899 bactericide agent Substances 0.000 description 1
- 239000011230 binding agent Substances 0.000 description 1
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- 125000004432 carbon atom Chemical group C* 0.000 description 1
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- 238000005553 drilling Methods 0.000 description 1
- 229960001484 edetic acid Drugs 0.000 description 1
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- 235000013773 glyceryl triacetate Nutrition 0.000 description 1
- FUZZWVXGSFPDMH-UHFFFAOYSA-N hexanoic acid Chemical compound CCCCCC(O)=O FUZZWVXGSFPDMH-UHFFFAOYSA-N 0.000 description 1
- 125000001183 hydrocarbyl group Chemical group 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
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- HDHLIWCXDDZUFH-UHFFFAOYSA-N irgarol 1051 Chemical compound CC(C)(C)NC1=NC(SC)=NC(NC2CC2)=N1 HDHLIWCXDDZUFH-UHFFFAOYSA-N 0.000 description 1
- 238000005304 joining Methods 0.000 description 1
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- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- 230000002906 microbiologic effect Effects 0.000 description 1
- 125000002347 octyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
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- 239000011120 plywood Substances 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 229920001451 polypropylene glycol Polymers 0.000 description 1
- ULWHHBHJGPPBCO-UHFFFAOYSA-N propane-1,1-diol Chemical class CCC(O)O ULWHHBHJGPPBCO-UHFFFAOYSA-N 0.000 description 1
- RUOJZAUFBMNUDX-UHFFFAOYSA-N propylene carbonate Chemical compound CC1COC(=O)O1 RUOJZAUFBMNUDX-UHFFFAOYSA-N 0.000 description 1
- HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 description 1
- 238000004062 sedimentation Methods 0.000 description 1
- 239000002453 shampoo Substances 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
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- 239000000344 soap Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000001384 succinic acid Substances 0.000 description 1
- IROINLKCQGIITA-UHFFFAOYSA-N terbutryn Chemical compound CCNC1=NC(NC(C)(C)C)=NC(SC)=N1 IROINLKCQGIITA-UHFFFAOYSA-N 0.000 description 1
- 229960002622 triacetin Drugs 0.000 description 1
- QCRXMFTZTSTGJM-UHFFFAOYSA-N triacetyl 2-hydroxypropane-1,2,3-tricarboxylate Chemical compound CC(=O)OC(=O)CC(O)(C(=O)OC(C)=O)CC(=O)OC(C)=O QCRXMFTZTSTGJM-UHFFFAOYSA-N 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/72—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
- A01N43/80—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms five-membered rings with one nitrogen atom and either one oxygen atom or one sulfur atom in positions 1,2
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
- A01N47/08—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having one or more single bonds to nitrogen atoms
- A01N47/10—Carbamic acid derivatives, i.e. containing the group —O—CO—N<; Thio analogues thereof
- A01N47/12—Carbamic acid derivatives, i.e. containing the group —O—CO—N<; Thio analogues thereof containing a —O—CO—N< group, or a thio analogue thereof, neither directly attached to a ring nor the nitrogen atom being a member of a heterocyclic ring
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Agronomy & Crop Science (AREA)
- Pest Control & Pesticides (AREA)
- Plant Pathology (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Dentistry (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Cosmetics (AREA)
- Detergent Compositions (AREA)
Abstract
一种杀微生物的组合物,其包含:(a)至少一种2-烷基-4-异噻唑啉-3-酮;(b)至少一种卤化丙炔基氨基甲酸酯;和(c)至少一种含硫的s-三嗪。
Description
本发明涉及一种选择的杀微生物剂的组合。
在一些情况下,由于对某些类型的微生物活性弱,例如,微生物对一些杀微生物剂有抵抗性,即便在高的使用浓度下,商业的杀微生物剂也不能提供对微生物的有效控制。在特殊的最终使用环境中,有时结合使用不同的杀微生物剂以对微生物提供总体的控制。例如,美国专利No.5,707,929公开了一种3-碘-2-丙炔基丁基氨基甲酸酯和含硫的s-三嗪的组合。然而,需要另外的杀微生物剂的组合以快速并且长期地提供对微生物的有效控制。本发明解决的一个问题就是提供这种杀微生物剂的另外的组合。
本发明解决的另一个问题是提供另外的杀微生物剂的组合,其含有最低量的由于毒性原因而不希望有的杀微生物剂。例如,已知的包括甲基-N-苯并咪唑-2-基氨基甲酸酯的杀生物剂的组合。然而,该化合物对非目标有机物的毒性使得较不希望显著量包括它的组合。同样地,也不希望大量含有卤化的3-异噻唑酮(3-isothiazolone)的组合。
发明概述
本发明涉及一种杀微生物的组合物,其包含:(a)至少一种2-烷基-4-异噻唑啉-3-酮;(b)至少一种卤化丙炔基氨基甲酸酯;和(c)至少一种含硫的s-三嗪。
发明详述
除非上下文明确地指出,这里使用的以下术语具有指定的定义。术语“杀微生物剂”指一种能够抑制或控制微生物在场所中增长的化合物;杀微生物剂包括杀细菌剂、杀真菌剂和灭藻剂。术语“微生物”包括,例如,真菌(比如酵母和霉菌),细菌和藻类。术语“场所”指被微生物污染的工业系统或产品。以下简称在说明书全文中使用:ppm=每百万份的重量部分(重量/重量)。除非另外限定,百分比(%)是重量百分比。“烷基”基团是具有以线形、支化或环形排列的1-20个碳原子的烃基基团。“芳基”基团是从芳族烃化合物衍生的取代基。芳基基团具有总数为6-20个的环原子,并且具有一个或多个单独或稠合的环。
优选,该至少一种含硫的s-三嗪是至少一种2-N-烷基-4-N-烷基-6-烷基硫代-1,3,5-三嗪-2,4-二基胺,即,以下结构式的化合物:
其中R1,R2和R3是烷基基团。优选,R1,R2和R3是C1-C6烷基,更优选C1-C4烷基。在一个优选实施方案中,R3是甲基。在一个优选实施方案中,R1和R2是C2-C4烷基。在一个优选实施方案中,该至少一种含硫的s-三嗪选自2-N-环丙基-4-N-叔丁基-6-甲基硫代-1,3,5-三嗪-2,4-二基胺(也称作Cybutryn,可以IrgarolTM1071从CIBA Spezialitaeten Chemie AG获得)和2-N-乙基-4-N-叔丁基-6-甲基硫代-1,3,5-三嗪-2,4-二基胺(也称作Terbutryn)。优选,该杀微生物的组合物包含至少1%的含硫的s-三嗪,更优选至少1.5%,和最优选至少2%。优选,该杀微生物的组合物包含不大于15%的含硫的s-三嗪,更优选不大于10%。在本发明的一个优选实施方案中,其中该至少一种含硫的s-三嗪是2-N-环丙基-4-N-叔丁基-6-甲基硫代-1,3,5-三嗪-2,4-二基胺,优选该组合物包含不高于7%的这种化合物,并且最优选不高于4%。
优选,该至少一种卤化丙炔基氨基甲酸酯是至少一种3-碘-2-丙炔基氨基甲酸酯,更优选3-碘-2-丙炔基烷基氨基甲酸酯或3-碘-2-丙炔基芳基氨基甲酸酯,和最优选3-碘-2-丙炔基C3-C6烷基氨基甲酸酯。在一个优选实施方案中,该至少一种卤化丙炔基氨基甲酸酯是3-碘-2-丙炔基正丁基氨基甲酸酯(“IPBC”)。优选,该杀微生物的组合物含有至少0.5%的卤化丙炔基氨基甲酸酯,更优选至少1.5%,更优选至少3%,更优选至少5%,和最优选至少8%。优选,该杀微生物的组合物含有不高于20%的卤化丙炔基氨基甲酸酯,更优选不高于15%,和最优选不高于12%。
本发明杀微生物的组合物优选含有不高于5%的卤化的3-异噻唑酮(3-isothiazolone);即,卤化的3-异噻唑酮的存在量为零到高至5%,优选为零到高至3%,更优选为零到高至2%,和最优选为零到高至1%。依赖于卤化的3-异噻唑酮的存在,杀微生物的组合物易于化学降解并且可能需要额外的稳定剂组分,比如金属盐稳定剂;盐稳定剂有时会在最终的配制剂中产生不可接受的性质。由于这种原因,希望提供基本上不含有卤化的3-异噻唑酮,但依然提供卤化的3-异噻唑酮所能够提供的杀微生物保护程度的杀微生物剂的配制剂。优选,本发明杀微生物的组合物基本上不含有甲基-N-苯并咪唑-2-基氨基甲酸酯,即,其含量小于0.5%,更优选小于0.3%,和最优选小于0.1%。
优选,该至少一种2-烷基-4-异噻唑啉-3-酮是至少一种取代的或未取代的2-(C4-C10)烷基-4-异噻唑啉-3-酮。取代的2-(C4-C10)烷基-4-异噻唑啉-3-酮在异噻唑酮环上的4-位和5-位中的一个或二者上可以包含(C1-C4)烷基或氯取代基。优选,该C4-C10烷基是辛基,最优选正辛基。在本发明的一个优选实施方案中,该至少一种2-(C4-C10)烷基-4-异噻唑啉-3-酮选自2-正辛基-4-异噻唑啉-3-酮(“OIT”)和4,5-二氯-2-正辛基-4-异噻唑啉-3-酮(“DCOIT”)。优选,该杀微生物的组合物含有至少0.2%的2-烷基-4-异噻唑啉-3-酮,更优选至少0.3%,和最优选至少0.4%。优选,该杀微生物的组合物含有不高于10%的2-烷基-4-异噻唑啉-3-酮,更优选不高于5%,更优选不高于3%,和最优选不高于2%。
除了在本申请中具体描述的这些,本发明杀微生物的组合物还非必要地包含其它杀虫的活性成分。
杀微生物剂的组分可以直接用于本发明的混合物中或者也可以首先与溶剂或固体载体配制在一起。合适的溶剂包括,例如,水;二元醇类,比如乙二醇、丙二醇、二甘醇、二丙二醇、聚乙二醇和聚丙二醇;二醇醚;醇类,比如甲醇、乙醇、丙醇、苯乙醇和苯氧基丙醇;酮类,比如丙酮和丁酮;酯类,比如乙酸乙酯、乙酸丁酯、三乙酰柠檬酸酯和甘油三乙酸酯;碳酸酯类,比如异丙二醇碳酸酯和碳酸二甲酯;以及它们的混合物。优选的溶剂选自水、二元醇类、二醇醚、酯类和它们的混合物。合适的固体载体包括,例如,环糊精、二氧化硅、硅藻土、蜡、纤维素质和活性炭。优选该杀微生物剂在水中配制。
当在溶剂中配制具有低的水中溶解度的杀微生物剂组分时,该配制剂可以非必要地包含表面活性剂。当这种配制剂含有表面活性剂时,它们通常采取可乳化的浓缩物、乳液、可微乳化的浓缩物或微乳液的形式。一旦加入足量的水后,可乳化的浓缩物会形成乳液。一旦加入足量的水后,可微乳化的浓缩物会形成微乳液。这种可乳化和可微乳化的浓缩物一般为本领域所众所周知;优选这种配制剂不含有表面活性剂。关于各种微乳液和可微乳化浓缩物进一步的一般和具体性的细节可以参考美国专利No.5,444,078。
具有低的水中溶解度的杀微生物剂组分也可以以分散体的形式配制。该分散体的溶剂组分可以是有机溶剂或水,优选水。这种分散体可以包含辅助剂,例如,共溶剂、增稠剂、防冻剂、分散剂、填料、色料、表面活性剂、稳定剂、防结垢剂和防腐添加剂。
在本发明的混合物中,任何杀微生物剂组分的任何配制剂可以与其它杀微生物剂组分的任何配制剂一起使用。当一种以上的杀微生物剂组分首先与溶剂配制在一起时,用于每一种杀微生物剂的溶剂可以与用于配制其它商业杀微生物剂的溶剂相同或者不同。优选,这些溶剂可溶混。在可供选择的另一种方法中,这些杀微生物剂可以直接结合,然后再在混合物中加入溶剂。
本领域的技术人员会认识到本发明杀微生物剂组分可以依次加入,同时加入或者结合后再加入到使用的场所。优选,杀微生物剂组分同时加入或者加入前先结合再加入到使用的场所。当杀微生物剂在加入到使用的场所前先结合时,这种结合可以非必要地包含辅助剂,比如,例如,溶剂、增稠剂、防冻剂、颜料、(多价)螯合剂(比如乙二胺四乙酸、乙二胺二琥珀酸、亚氨基二琥珀酸和它们的盐)、分散剂、表面活性剂、稳定剂、防结垢剂和防腐添加剂。
通过将有效量的杀微生物的组合物加入到经受微生物腐蚀的场所上、场所里或其中,本发明杀微生物的组合物可用于抑制微生物的生长。合适的场所包括,例如:冷却塔;空气洗涤器;锅炉;矿物淤浆;废水处理;装饰性喷泉;反渗透过滤;超滤;压舱水(ballast water);蒸发冷凝器;热交换器;纸浆和纸张加工流体;塑料;乳液;分散体;油漆;胶乳;涂料,比如清漆;建筑产品,比如厚浆涂料,填隙和密封材料;建筑粘合剂,比如陶瓷粘合剂,地毯背胶(backing adhesive),和层压粘合剂;工业或消费品粘合剂;照相药品;印刷流体;家用产品,比如浴室和厨房清洁剂;化妆品;化妆用品;洗发剂;肥皂;洗涤剂;工业清洁剂;地板蜡;洗衣漂洗水;金属加工流体;传送带润滑剂;水力流体;皮革和皮革产品;织物;织物产品;木材和木材产品,比如胶合板,粗纸板,刨花板,层压梁,定向线板(orientedstrandboard),硬纸板和碎料板;石油加工流体;燃料;油田流体,比如注射水,压裂液和钻探泥浆;农业辅助防腐剂;表面活性剂防腐剂;医疗设备;诊断试剂防腐剂;食品防腐剂,比如塑料或纸的食品包装;沉淀池和矿泉(spas)。
优选,本发明杀微生物的组合物可用于在选自一种或多种乳液、分散体、油漆、胶乳、家用产品、洗涤剂和工业清洁剂的场所中抑制微生物的生长。特别地,该杀微生物的组合物在乳液、分散体、油漆和胶乳中有用。
场所中抑制或控制微生物生长所必需的组合物的具体含量依赖于组合物中特定的化合物和被保护的特定场所。典型地,如果在场所中提供50-20,000ppm活性成分的组合物,本发明组合物的含量在场所中足以控制微生物的生长。优选在场所中存在的组合物含量为至少100ppm,更加优选至少200ppm,更加优选至少300ppm,和最优选至少500ppm。优选本发明的组合物在场所中的含量不高于10,000ppm,更加优选不高于7,000ppm,和最优选不高于5,000ppm。
在本发明一个优选实施方案中,该杀微生物的组合物包含2%的2-正辛基-4-异噻唑啉-3-酮,10%的3-碘-2-丙炔基正丁基氨基甲酸酯和3%的2-N-环丙基-4-N-叔丁基-6-甲基硫代-1,3,5-三嗪-2,4-二基胺。在本发明的另一个优选实施方案中,该杀微生物的组合物包含2%的2-正辛基-4-异噻唑啉-3-酮,0.4%的4,5-二氯-2-正辛基-4-异噻唑啉-3-酮,10%的3-碘-2-丙炔基正丁基氨基甲酸酯和3%的2-N-环丙基-4-N-叔丁基-6-甲基硫代-1,3,5-三嗪-2,4-二基胺。
Claims (8)
1.一种杀微生物的组合物,其包含:
(a)至少一种2-烷基-4-异噻唑啉-3-酮;
(b)至少一种卤化丙炔基氨基甲酸酯;和
(c)至少一种含硫的s-三嗪。
2.权利要求1的组合物,其中所述至少一种2-烷基-4-异噻唑啉-3-酮是至少一种取代或未取代的2-(C4-C10)烷基-4-异噻唑啉-3-酮。
3.权利要求2的组合物,其中所述至少一种卤化丙炔基氨基甲酸酯是至少一种3-碘-2-丙炔基氨基甲酸酯。
4.权利要求3的组合物,其中所述至少一种含硫的s-三嗪是至少一种2-N-烷基-4-N-烷基-6-烷基硫代-1,3,5-三嗪-2,4-二基胺。
5.权利要求4的组合物,其中所述至少一种取代或未取代的2-(C4-C10)烷基-4-异噻唑啉-3-酮存在的总含量是0.2%-5%。
6.权利要求5的组合物,其中所述至少一种3-碘2-丙炔基氨基甲酸酯存在的总含量是5%-15%。
7.权利要求6的组合物,其中所述至少一种2-N-烷基-4-N-烷基-6-烷基硫代-1,3,5-三嗪-2,4-二基胺存在的总含量是1.5%-15%。
8.权利要求7的组合物,其中所述至少一种3-碘-2-丙炔基氨基甲酸酯是3-碘-2-丙炔基正丁基氨基甲酸酯,所述至少一种2-N-烷基-4-N-烷基-6-烷基硫代-1,3,5-三嗪-2,4-二基胺选自2-N-环丙基-4-N-叔丁基-6-甲基硫代-1,3,5-三嗪-2,4-二基胺和2-N-乙基-4-N-叔丁基-6-甲基硫代-1,3,5-三嗪-2,4-二基胺,并且所述至少一种取代或未取代的2-(C4-C10)烷基-4-异噻唑啉-3-酮选自2-正辛基-4-异噻唑啉-3-酮和4,5-二氯-2-正辛基-4-异噻唑啉-3-酮。
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