CN1530125A - Medicie composition, preparing method and use for preparing gynaecopathia medicine - Google Patents
Medicie composition, preparing method and use for preparing gynaecopathia medicine Download PDFInfo
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- CN1530125A CN1530125A CNA031194923A CN03119492A CN1530125A CN 1530125 A CN1530125 A CN 1530125A CN A031194923 A CNA031194923 A CN A031194923A CN 03119492 A CN03119492 A CN 03119492A CN 1530125 A CN1530125 A CN 1530125A
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Abstract
A Chinese medicine in the form of tablet, capsule, powder, particles, oral liquid and injection for treating gynopathy is prepared from 4 Chinese-medicinal materials: flavescent sophora root, cnidium fruit, rhubarb and ginseng through unique process. Its advantages are quickly taking its effect, high cure rate and short course of treatment.
Description
Technical field
The present invention relates to a kind of is pharmaceutical composition, its preparation method and the application in preparation treatment medicine for gynecopathy thereof of material with the plant.
Background technology
Gynaecopathia is commonly encountered diseases, a frequently-occurring disease clinically, the medicine that is used for the treatment of gynaecopathia at present is varied, for example, CN1064541C discloses a kind of medicine for the treatment of female chronic inflammation, this medicine contains the protozoa of Chinese medicines such as astragalin, Herba Melastomatis dodecandri phenols and plant amino acid, flavonoid, nitidine, Radix Angelicae Sinensis volatile oil, is used for the treatment of blood deficiency, blood valve that female chronic inflammation causes.CN1101272A discloses the medicine that a kind of gynecological is used for regulating menstruation, hemostasis and anti-inflammation, and this medicine is formulated by Radix Et Rhizoma Rhei, Colla Corii Asini, Cortex Moutan, Pollen Tyjphae, the Radix Astragali, Herba Agrimoniae.CN1161850A discloses a kind of styptic for gynaecology, and this medicine is formulated by Herba Euphorbiae Humifusae, the Radix Astragali, Colla Corii Asini, Fructus Jujubae, brown sugar.CN1286989 discloses a kind of suppository for the treatment of the gynaecologic vaginal disease, this medicine is to disclose a kind of medicine for the treatment of slack vagina with Cortex Phellodendri, Rhizoma Curcumae, Herba Polygoni Avicularis, dried Alumen, Pericarpium Zanthoxyli, the formulated CN1334082 of Mel, and this medicine is formulated by the Radix Astragali, Fructus Mume, Galla Chinensis, Fructus Lycii.These medicines can not effectively be delivered to the depths of vagina, because the self purification of vagina, when foreign body exists, can increase liquid secretion, at short notice medicine is got rid of external, both reduced curative effect, prolonged the course of treatment again, the increase expense is polluted underwear again, and these medicines existence take effect slow, curative effect is not remarkable, or shortcoming such as side effect is big.
Curative effect at the medicine of gynaecopathia medial vagina inflammation is all undesirable, and it is slower to take effect, and easily repeatedly, is badly in need of a kind of instant effect, side effect is little, biocidal property is strong medicine at present, to remove patient's misery.
Summary of the invention
The object of the invention is to provide a kind of pharmaceutical composition, and this pharmaceutical composition is a pure Chinese medicinal preparation, and its prescription rationally has good heat clearing away, dampness, antipruritic, germ-resistant effect.
Another object of the present invention is to provide this preparation of drug combination method, and this method technology uniqueness is easy and simple to handle.
A further object of the invention is to provide the application of this pharmaceutical composition in preparation treatment medicine for gynecopathy.
A kind of pharmaceutical composition of the present invention is characterized in that the composition of this pharmaceutical composition and weight proportion are:
19 parts～56 parts of Radix Sophorae Flavescentiss
21 parts～62 parts of Fructus Cnidiis
6 parts～18 parts of Radix Et Rhizoma Rhei
5 parts～15 parts of Radix Ginsengs.
A kind of pharmaceutical composition preferred weight proportioning of the present invention is:
25 parts～45 parts of Radix Sophorae Flavescentiss
30 parts～50 parts of Fructus Cnidiis
8 parts～12 parts of Radix Et Rhizoma Rhei
8 parts～12 parts of Radix Ginsengs.
The said weight portion of the present invention can be gram, jin, kilogram or ton etc.
A kind of preparation of drug combination method of the present invention is characterized in that this method may further comprise the steps:
1) Fructus Cnidii is added twice of ethanol extraction and filtration by proportioning, merging filtrate is concentrated into extractum;
2) Radix Sophorae Flavescentis, Radix Et Rhizoma Rhei, Radix Ginseng are decocted with water twice and filter by proportioning, merging filtrate leaves standstill and gets supernatant, is concentrated into extractum;
3) merge 1,2 step gained extractum, mixing, spray drying gets the medicine fine powder.
Wherein concentration of ethanol is 60%～80% in the step 1), for the first time amount of alcohol added is 4～6 times of Fructus Cnidii amount, for the second time amount of alcohol added is 2～4 times of Fructus Cnidii amount, and each extraction time is 1～2 hour, and the relative density of extractum is 1.22～1.26 (60 ℃～70 ℃ surveys);
Step 2) in for the first time amount of water be 8～12 times of Chinese crude drug amount, decocted 2～3 hours, amount of water is 5～8 times of amounts of Chinese crude drug amount for the second time, decocts 1～2 hour, time of repose is 18～36 hours, and the relative density of extractum is 1.22～1.26 (60 ℃～70 ℃ surveys).
Precipitation appears in of the present invention leaving standstill at ambient temperature, filter supernatant.
During to the Fructus Cnidii reflux, extract,,, can adopt a reflux in the preparation of drug combination method of the present invention, reclaim ethanol, ethanol can be recycled in order to reduce alcoholic acid loss.
Spray drying method of the present invention is: with extractum with 3～6kg/cm
2Pressure through mister head, become the droplet shape to spray in the hothouse, mix with the thermal current that is heated to 250～300 ℃ simultaneously, after heat exchange, be dried, promptly get dried powder.
Pharmaceutical composition of the present invention can adopt conventional method to make various preparations, such as a kind of dosage forms wherein such as suppository, oral tablet, capsule, powder, granule, oral liquid or injection, preferably suppository.
If make suppository, then get the substrate heating and melting, 50 ℃～60 ℃ of temperature add medicine fine powder of the present invention, and stirring in water bath is even, is mixed into heavy-gravity liquid, is poured in the plastics calibration tube, inserts tampon, and cooling and shaping is made similar warhead shape tampon.General used substrate can be: semi-synthetic fatty acid glyceride, lanoline, Polyethylene Glycol, poloxamer etc., the proportioning of medicine fine powder and substrate is 1: 2～1: 4, is preferably 1: 3.
For easy to use, tampon can select for use afterbody to have the tampon of cotton thread.
The present invention adopts stype and the incorporate advanced technologies of tampon, remedied the deficiency of ordinary suppository, ordinary suppository can not effectively be delivered to the depths of vagina, because the self purification of vagina when foreign body exists, can increase liquid secretion, at short notice medicine is got rid of external, both reduced curative effect, and prolonged the course of treatment again, the increase expense is polluted underwear again.The suppository that the present invention makes can be given full play to curative effect of medication, and it is good to have a safety, and practicality is big, the advantage that feasibility is good.
The detailed directions of this suppository is as follows: drug suppository of the present invention is removed cabinet, take out stype, pull out the afterbody cotton thread, include stype in the vagina deep, cotton thread is stayed external, 1 every night, rises morning next day and pulls out tampon, one week of continuous use.
A kind of pharmaceutical composition of the present invention can be according to different needs, by well known to a person skilled in the art that technology and equipment makes oral tablet, capsule, powder, granule, oral liquid or injection a kind of dosage form wherein.
Application in the secretions increase that a kind of pharmaceutical composition of the present invention causes as preparation treatment female vagina, the medicine that abnormal flavour and pruritus vulvae disease are arranged.
The present invention adopts tcm clinical practice to use active drug Fructus Cnidii, Radix Sophorae Flavescentis, Radix Et Rhizoma Rhei always, and it has stronger inhibition killing action to antibacterial, virus, infusorian, mycete etc., so curative effect is better, the injury repairing of Radix Ginseng pair cell has more satisfactory effect simultaneously.The present invention concentrates effective ingredient and the performance property of medicine and performance synergism separately with the extraction of new and high technology to the Chinese medicine ultimate constituent, makes the better efficacy of this medicine.
A kind of pharmacodynamic study and toxicity (is example with suppository) for the treatment of the pharmaceutical composition of gynaecopathia of the present invention is studied as follows:
One. antibiotic, antivirus test
1. in-vitro antibacterial test
This medicine is 1: 200 to group B streptococcus, staphylococcus aureus, colibacillary minimal inhibitory concentration, gonococcus is 1: 200, Candida albicans is 1: 400, the time of killing during to 1: 25 dilution factor of trichomonas vaginitis is 5 minutes, 1: 50 o'clock is 10 minutes, 1: 100 o'clock is 20 minutes, and 1: 200 o'clock is 40 minutes, and 1: 400 o'clock is 8 hours.
2. antibacterial tests in the body
Can obviously reduce mortality rate to mouse peritoneal ehec infection and staphylococcus aureus.Compare with the normal saline matched group (P＜0.025)
3. extracorporeal antivirus effect test
Filterable virus there are inhibition and killing action.
Two. the antiinflammatory test
1. xylol and histamine phosphate's induced mice capillary permeability increase obvious inhibitory action.Compare with the normal saline matched group (P＜0.05)
2. the inhibitory action that Oleum Tiglii induced mice auricle edema is had highly significant.Compare with the normal saline matched group (P＜0.01)
3. the inhibitory action that rat paw edema due to the Ovum Gallus domesticus album is had highly significant.Compare with the normal saline matched group (P＜0.01)
4. the generation to rat cotton balls granuloma has significant inhibitory effect.Compare with the normal saline matched group (P＜0.05)
Three. the analgesic test
1. the writhing response due to the mice stomachache that causes of Dichlorodiphenyl Acetate has the inhibitory action of highly significant.Compare with the normal saline matched group (P＜0.01)
2. the mice hot plate is caused pain and have tangible raising threshold function.Compare with the normal saline matched group (P＜0.05)
Conclusion: prove that by pharmacodynamics test this medical instrument has effects such as good antibiotic, antiviral, antiinflammatory, paroxysmal pain.
Toxicity test
One. acute toxicity test
Give Cavia porcellus intravaginal dispensing with 200 times of the clinical consumption per day of this product, observed 7.All animals are strong as a result deposits, and its activity, diet, hair, Excreta are no abnormal, do not see toxic reaction.
Two. the skin irritation test
Cavia porcellus vagina and damaged skin are carried out irritation test, and not seeing has irritative response and other untoward reaction.
Toxicity test proves: not toxic effect of this medicine and untoward reaction, clinical practice is safe and reliable.
Because the suppository made of pharmaceutical composition of the present invention is a kind of novel vaginal suppository, have good heat clearing away, dampness, curative effect such as antipruritic, for verifying its curative effect, the spy does clinical observation, clinical practice 444 examples, wherein 315 examples are organized in treatment, adopt the matched group 129 routine visual reports of metronidazole,clotrimazole and chlorhexidine acetate suppositories.
The result is as follows:
Selected case is an Affiliated Hospital of Heilongjiang University of Chinese Medicine, and No.1 Hospital Attached to Harbin Medical Univ. carries out clinical observation and research to gynecological's inflammatory diseases, studies case 444 examples altogether, and patient's minimal ages is 25 years old, maximum 65 years old age.Have following disease after diagnosing:
1. because the femal sexual function that infection such as antibacterial, virus, infusorian cause is low, hyposexuality.
2. vaginal dryness, pruritus vulvae, causalgia or with the local excitation symptom.
3. gynecologial examination secretions is unusual, and trichomonal vaginitis secretions is yellow cystose; Colpitis mycotica secretions is the bean dregs sample; Senile vaginitis secretions is pus sample or yellow fluid sample.Lab testing: trichomonal vaginitis, microscopically can find infusorian in the vaginal secretions; Colpitis mycotica can be found mycete in secretions; The vagina cleanliness factor is more than II °.
Observational technique:
The vagina middle part is directly filled in drug suppository of the present invention oneself in vaginadouche (in hospital) or do not wash and be in and work, once a day, and seven days courses of treatment.
Observation index:
1. clinical manifestation: comprise the vaginitis symptom, the variation of leukorrhagia and menstrual blood volume, color, matter
2. gynecologial examination: comprise pelvioscopy and examination of vulva
3. vaginal secretions inspection: comprise under the mirror, smear and physical behavior inspection
Curative effect determinate standard:
1. recovery from illness: transference cure, gynecologial examination and lab testing recover normal, and integration transfers 0 to.
2. produce effects: symptom obviously alleviates, and gynecologial examination and lab testing are clearly better, and integration reduces more than 2/3 before treating the back and treating.
3. effective: sx, gynecologial examination and lab testing take a turn for the better, and treat the back and reduce more than 1/3 than integration before treating.
4. invalid: the treatment back does not change than having before treating.
Observed result is as shown in the table:
Drug suppository total effects of the present invention is observed table
| Group | The example number | Recovery from illness | Produce effects | Effectively | Invalid | Effective percentage (%) |
| The treatment group | 315 | ????201 | ????72 | ????39 | ????3 | ??99.04 |
| Matched group | 129 | ????3 | ????8 | ????54 | ????64 | ??50.38 |
All effective in cure between two groups to gynecological's inflammatory diseases, but significant difference (P＜0.01) is relatively arranged between two groups.
Confirm through clinical observation, the suppository determined curative effect of pharmaceutical composition of the present invention, has diseases such as abnormal flavour and pruritus vulvae that better curative effect is arranged at the secretions increase that vaginitis is caused, the treatment total effective rate reaches 99.04%, and not having allergy and untoward reaction, is a kind of convenience, safe and reliable medicine.
A kind of pharmaceutical composition of the present invention is owing to select for use rare Chinese medicine Radix Sophorae Flavescentis, Fructus Cnidii, Radix Et Rhizoma Rhei, Radix Ginseng etc. formulated, has heat clearing away, dampness, antipruritic, germ-resistant effect is applicable to secretions increase that female vagina causes, diseases such as abnormal flavour and pruritus vulvae is arranged, it treats convenient, can be thoroughly clean, eliminate abnormal flavour, symptoms such as secretions increase and pruritus vulvae, instant effect, the cure rate height, the cycle is short.
The specific embodiment
Below be embodiments of the invention, the embodiment that the present invention provides is in order to further specify the specific embodiments of the invention scheme, rather than is used for limiting protection scope of the present invention.
Embodiment 1
Get 500 gram Fructus Cnidiis and add 70% alcohol reflux secondary, add ethanol 2500 grams for the first time, refluxed 1.5 hours, add ethanol 1500 grams for the second time, refluxed 1 hour, and filtered merging filtrate, reclaim ethanol, be concentrated into the extractum of relative density 1.22 (60 ℃ time survey), standby;
Get 350 the gram Radix Sophorae Flavescentiss, 100 the gram Radix Et Rhizoma Rhei, 50 the gram Radix Ginsengs decoct with water twice, amount of water is 5000 grams for the first time, decocted 2 hours, amount of water is 3000 grams for the second time, decocts 1.5 hours, filters, filtrate merges, left standstill 24 hours, and drew supernatant, be concentrated into relative density and be 1.23 extractum of (60 ℃ time survey); With twice extractum mixing, with extractum with 3kg/cm
2Pressure through mister head, become the droplet shape to spray in the hothouse, mix with the thermal current that is heated to 250 ℃ simultaneously, after heat exchange, be dried, promptly get dry medicated powder;
Get 1000 gram semi-synthetic fatty acid glyceride and be heated to 50 ℃ of thawings, with the above-mentioned medicated powder mixing of 300 grams, fully be mixed into heavy-gravity liquid, be poured in the plastics shaper, insert tampon, cooling and shaping is made similar warhead shape tampon, promptly makes 500 pieces of suppositorys.
Embodiment 2
Get 350 gram Fructus Cnidiis and add 65% alcohol reflux secondary, add ethanol 2100 grams for the first time, refluxed 2 hours, add ethanol 1050 grams for the second time, refluxed 1.5 hours, and filtered merging filtrate, reclaim ethanol, be concentrated into the extractum of relative density 1.24 (70 ℃ time survey), standby;
Get 400 the gram Radix Sophorae Flavescentiss, 150 the gram Radix Et Rhizoma Rhei, 100 the gram Radix Ginsengs decoct with water twice, amount of water is 6500 grams for the first time, decocted 2.5 hours, amount of water is 3900 grams for the second time, decocts 2 hours, filters, filtrate merges, left standstill 36 hours, and drew supernatant, be concentrated into relative density and be 1.26 extractum of (60 ℃ time survey); With twice extractum mixing, with extractum with 5kg/cm
2Pressure through mister head, become the droplet shape to spray in the hothouse, mix with the thermal current that is heated to 280 ℃ simultaneously, after heat exchange, be dried, promptly get dry medicated powder;
Get 1004 gram lanolines and be heated to 55 ℃ of thawings, with the above-mentioned medicated powder mixing of 250 grams, fully be mixed into heavy-gravity liquid, be poured in the plastics shaper, insert tampon, cooling and shaping is made similar warhead shape tampon, promptly makes 500 pieces of suppositorys.
Embodiment 3
Preparation method is with embodiment 1, and the component of different pharmaceutical compositions is Radix Sophorae Flavescentis 450 grams, Fructus Cnidii 600 grams, Radix Et Rhizoma Rhei 60 grams, Radix Ginseng 150 grams; Concentration of ethanol is 80%, when extracting Fructus Cnidii for the first time amount of alcohol added be 6 times of Fructus Cnidii amount, amount of alcohol added is 4 times of Fructus Cnidii amount for the second time, each extraction time is 115 hours, the relative density of extractum is 1.26 (70 ℃ of surveys);
During water extraction, for the first time amount of water is 9 times of Chinese crude drug amount, decocts 3 hours, and the second time, amount of water was 7 times of amounts of Chinese crude drug amount, decocted 1 hour, and time of repose is 24 hours, and the relative density of extractum is 1.24 (70 ℃ of surveys).
Used substrate is poloxamer, and the proportioning of substrate and medicated powder is 1: 3.
Embodiment 4
With embodiment 1, the component of different pharmaceutical compositions is Radix Sophorae Flavescentis 250 grams, Fructus Cnidii 210 grams, Radix Et Rhizoma Rhei 180 grams, Radix Ginseng 80 grams.
Embodiment 5
With embodiment 4, different is by well known to a person skilled in the art method, will making soft material behind 100 gram medicine fine powders and the 10 gram dry starch mixings, cross 16 mesh sieves and make granule, add 95% ethanol mixing after the drying, with the compacting of 10mm biconvex punch die in flakes, promptly get medicinal tablet.The suggestion instructions of taking is: three times on the one, and one time 0.5 gram.
Embodiment 6
With embodiment 2, the component of different pharmaceutical compositions is Radix Sophorae Flavescentis 200 grams, Fructus Cnidii 500 grams, Radix Et Rhizoma Rhei 120 grams, Radix Ginseng 120 grams.
Embodiment 7
With embodiment 6, different is by well known to a person skilled in the art method, with the medicine fine powder, crosses 100 mesh sieves, adds 1 milliliter of orange peel oil, mixing, and subpackage promptly gets powder.The suggestion instructions of taking is: three times on the one, and one time 0.5 gram.
Embodiment 8
With embodiment 3, the component of different pharmaceutical compositions is Radix Sophorae Flavescentis 560 grams, Fructus Cnidii 300 grams, Radix Et Rhizoma Rhei 80 grams, Radix Ginseng 70 grams.
Embodiment 9
With embodiment 8, different is by well known to a person skilled in the art method, with the medicine fine powder, crosses 100 mesh sieves, in 60 ℃ of oven dry, encapsulated.The suggestion instructions of taking is: three times on the one, and one time 0.5 gram.
Embodiment 10
With embodiment 1, the component of different pharmaceutical compositions is Radix Sophorae Flavescentis 300 grams, Fructus Cnidii 450 grams, Radix Et Rhizoma Rhei 100 grams, Radix Ginseng 150 grams.
Embodiment 11
With embodiment 10, different is by well known to a person skilled in the art method, the fine powder that spray drying is obtained is dissolved among water for injection and the NaCL, transferring PH is 7.2, add 0.15% activated carbon again and boiled 15 minutes, after the cooling, with the buchner funnel sucking filtration to medicinal liquid clear and bright after, add the injection water and become 1000 milliliters, sintered glass funnel filters.Embedding, 100 ℃ of flowing steam sterilizations 30 minutes promptly get injection.The suggestion instructions of taking is: once-a-day, and 20 milliliters of intravenous injections.
Embodiment 12
With embodiment 1, the component of different pharmaceutical compositions is Radix Sophorae Flavescentis 190 grams, Fructus Cnidii 620 grams, Radix Et Rhizoma Rhei 60 grams, Radix Ginseng 100 grams.
Embodiment 13
With embodiment 12, different is by well known to a person skilled in the art method, and the fine powder that spray drying is obtained is dissolved in water for injection, filters, and adds simple syrup, sodium benzoate, adds water to 1000 milliliters again, and cold preservation is filtered.Embedding with 100 ℃ of flowing steam sterilizations 30 minutes, promptly gets oral liquid in the 10ml ampoule.The suggestion instructions of taking be: three times on the one, one time 50 milliliters.
Although the present invention has been done detailed explanation and quoted some instantiations as proof, for a person skilled in the art, only otherwise leave the spirit and scope of the present invention, it is obvious doing various variations or correction.
Claims (8)
1. pharmaceutical composition is characterized in that the composition of this pharmaceutical composition and weight proportion are:
19 parts～56 parts of Radix Sophorae Flavescentiss
21 parts～62 parts of Fructus Cnidiis
6 parts～18 parts of Radix Et Rhizoma Rhei
5 parts～15 parts of Radix Ginsengs.
2. a kind of pharmaceutical composition according to claim 1 is characterized in that the composition of pharmaceutical composition and weight proportion are:
25 parts～45 parts of Radix Sophorae Flavescentiss
30 parts～50 parts of Fructus Cnidiis
8 parts～12 parts of Radix Et Rhizoma Rhei
8 parts～12 parts of Radix Ginsengs.
3. the described a kind of preparation of drug combination method of claim 1 is characterized in that this method may further comprise the steps:
1) Fructus Cnidii is added twice of ethanol extraction and filtration by proportioning, merging filtrate is concentrated into extractum;
2) Radix Sophorae Flavescentis, Radix Et Rhizoma Rhei, Radix Ginseng are decocted with water twice and filter by proportioning, merging filtrate leaves standstill and gets supernatant, is concentrated into extractum;
3) merge 1,2 step gained extractum, mixing, spray drying gets the medicine fine powder.
4. a kind of preparation of drug combination method according to claim 3, it is characterized in that concentration of ethanol is 60%～80% in the step 1), for the first time amount of alcohol added is 4～6 times of Fructus Cnidii amount, for the second time amount of alcohol added is 2～4 times of Fructus Cnidii amount, each extraction time is 1～2 hour, and the relative density of extractum is 1.22～1.26.
5. a kind of preparation of drug combination method according to claim 3, it is characterized in that step 2) in for the first time amount of water be 8～12 times of Chinese crude drug amount, decocted 2～3 hours, amount of water is 5～8 times of amounts of Chinese crude drug amount for the second time, decocted 1～2 hour, time of repose is 18～36 hours, and the relative density of extractum is 1.22～1.26.
6. a kind of pharmaceutical composition according to claim 1 is characterized in that pharmaceutical composition can be made into suppository, oral tablet, capsule, powder, granule, oral liquid and injection a kind of dosage form wherein, is preferably suppository.
7. a kind of pharmaceutical composition according to claim 6, it is characterized in that pharmaceutical composition makes suppository and can adopt following method: get the substrate heating and melting, 50～60 ℃ of temperature, add medicine fine powder of the present invention, stirring in water bath is even, be mixed into heavy-gravity liquid, be poured in the plastics calibration tube, insert tampon, cooling and shaping is made similar warhead shape tampon, general used substrate can be: semi-synthetic fatty acid glyceride, lanoline, Polyethylene Glycol, poloxamer, the proportioning of medicine fine powder and substrate is 1: 2～1: 4, is preferably 1: 3.
The secretions increase that causes as preparation treatment female vagina of the described a kind of pharmaceutical composition of claim 1, abnormal flavour and pruritus vulvae disease are arranged medicine in application.
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| Application Number | Priority Date | Filing Date | Title |
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| CN 03119492 CN1262292C (en) | 2003-03-13 | 2003-03-13 | Medicie composition, preparing method and use for preparing gynaecopathia medicine |
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| CN 03119492 CN1262292C (en) | 2003-03-13 | 2003-03-13 | Medicie composition, preparing method and use for preparing gynaecopathia medicine |
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| CN1530125A true CN1530125A (en) | 2004-09-22 |
| CN1262292C CN1262292C (en) | 2006-07-05 |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103494896A (en) * | 2013-10-11 | 2014-01-08 | 哈尔滨欧替药业有限公司 | Cnidium monnieri and rheum officinale vaginal dilation suppository as well as preparation method and detection method thereof |
| CN103751300A (en) * | 2013-12-31 | 2014-04-30 | 哈尔滨欧替药业有限公司 | Refined traditional Chinese medicine composition for pyrite nodule vaginal expansion suppository, vaginal expansion suppository and preparation method of vaginal expansion suppository |
| CN114028469A (en) * | 2021-12-13 | 2022-02-11 | 四川省中医药科学院中医研究所 | Pharmaceutical composition for nursing female private parts |
-
2003
- 2003-03-13 CN CN 03119492 patent/CN1262292C/en not_active Expired - Fee Related
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103494896A (en) * | 2013-10-11 | 2014-01-08 | 哈尔滨欧替药业有限公司 | Cnidium monnieri and rheum officinale vaginal dilation suppository as well as preparation method and detection method thereof |
| CN103494896B (en) * | 2013-10-11 | 2015-03-04 | 哈尔滨欧替药业有限公司 | Cnidium monnieri and rheum officinale vaginal dilation suppository as well as preparation method and detection method thereof |
| CN103751300A (en) * | 2013-12-31 | 2014-04-30 | 哈尔滨欧替药业有限公司 | Refined traditional Chinese medicine composition for pyrite nodule vaginal expansion suppository, vaginal expansion suppository and preparation method of vaginal expansion suppository |
| CN103751300B (en) * | 2013-12-31 | 2016-02-24 | 哈尔滨欧替药业有限公司 | For the refining Chinese medicine composition of the yellow vaginal expansion plug agent of Serpentis and expansible plug thereof and method for making |
| CN114028469A (en) * | 2021-12-13 | 2022-02-11 | 四川省中医药科学院中医研究所 | Pharmaceutical composition for nursing female private parts |
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| Publication number | Publication date |
|---|---|
| CN1262292C (en) | 2006-07-05 |
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