CN1528421A - Soft capsule for tranquilizing uterine blood and preparing method thereof - Google Patents
Soft capsule for tranquilizing uterine blood and preparing method thereof Download PDFInfo
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- CN1528421A CN1528421A CNA2003101078132A CN200310107813A CN1528421A CN 1528421 A CN1528421 A CN 1528421A CN A2003101078132 A CNA2003101078132 A CN A2003101078132A CN 200310107813 A CN200310107813 A CN 200310107813A CN 1528421 A CN1528421 A CN 1528421A
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Abstract
The present invention relates to a medicine Gongxuening soft capsule and its preparation method. It is made up by using (wt%) 10%-30% of seclused chamber extract and 70%-90% of auxiliary material to make capsule liquid, and using 30%-60% of gelatin or polyethylene glycol, 0.8%-2% of glycerine, 0.1%-0.5% of additive composed of antioxidant and preservative and 28%-55% of water to form capsule shell material and adopting drip-making or pressing process to obtain the invented soft capsule. Said invention is convenient for administration, can quickly obtain therapeutic effect, and is high in biological utilization rate and small in side effect.
Description
Technical field
What the present invention relates to is a kind of Chinese patent medicine novel formulation and preparation method thereof, and referring in particular to a kind of is the GONGXUENING soft capsule and preparation method thereof of raw material with the Chinese herbal medicine Rhizoma Paridis extract.
Background technology
Rhizoma Paridis belongs to liliaceous plant, and there is distribution in the most of area of China, main product in Yunnan, ground such as Guizhou, Sichuan, Guangxi.Chinese medicine Rhizoma Paridis medicinal history is long, is stated from Shennong's Herbal with the name head of Rhizoma Paridis, calls Rhizoma Paridis in Tang Materia Medica, mainly contains effects such as heat-clearing and toxic substances removing, reducing swelling and alleviating pain, the arresting convulsion of cool liver, is used to treat swollen carbuncle, laryngopharynx swelling and pain snake venom disease such as bite.The Rhizoma Paridis main component is Rhizoma Paridis saponin, diosgenin, pennogenin etc., main active is diosgenin and pennogenin, process water is carried with methanol eddy and being extracted, content with the clear sapogenin of determination of color potato, containing the pre-saponin of potato in the water extract does not hardly have, and content is higher in the methanolic extract.In recent years, pharmacological research shows that this platymiscium has hemostasis, antitumor, the physiologically active of aspects such as immunomodulating and cardiovascular.The dosage form made from Rhizoma Paridis tablet, capsule etc. are arranged.
Summary of the invention
The object of the present invention is to provide a kind of is the GONGXUENING soft capsule of raw material with Chinese herbal medicine Rhizoma Paridis ethanol extract.
It is the GONGXUENING preparation of soft capsule method of raw material with Chinese herbal medicine Rhizoma Paridis ethanol extract that another object of the present invention provides a kind of
The present invention is implemented by following scheme.
A kind of GONGXUENING soft capsule of the present invention comprises capsule liquid, softgel shell, and it is made of following component and weight proportion:
By weight percentage
Capsule liquid is made up of the extract dry extract powder 10%-30% and the adjuvant 70%-90% that contain diosgenin and pennogenin;
Softgel shell is made up of gelatin or Polyethylene Glycol 30%-60%, glycerol 0.8%-2%, additives 0.1%-0.5% and water 28%-55%.
And the weight proportion of each component can be preferably:
By weight percentage
Capsule liquid is made up of the extract dry extract powder 15%-25% and the adjuvant 75%-85% that contain diosgenin and pennogenin;
Softgel shell is gelatin or Polyethylene Glycol 35%-50%, glycerol 1.0%-1.6%, additives 0.2%-0.4% and water 32%-48%.
Weight proportion the best of each component is:
By weight percentage
Capsule liquid is made up of the extract dry extract powder 18%-22% and the adjuvant 78%-82% that contain diosgenin and pennogenin;
Softgel shell is gelatin or Polyethylene Glycol 40%-50%, glycerol 1.2%-1.4%, additives 0.25%-0.35% and water 38%-44%.
The Chinese medicinal soft capsule of the prophylactic treatment flu that above-mentioned composition constitutes, described adjuvant can be diluent, suspending agent, antioxidant, surfactant and antiseptic; Described additives can be antiseptic, antioxidant.
And described diluent is preferably vegetable oil, and suspending agent is preferably oily wax mixture, Cera Flava, and antioxidant is preferably dibenzylatiooluene, and antiseptic is preferably the benzyl p-hydroxybenzoate class.
GONGXUENING preparation of soft capsule method of the present invention, it mainly comprises following process steps:
(1) gelatin, the dissolving of water heating in water bath mix mutually with glycerol, add antiseptic again, stir, and are incubated set aside for use after the vacuum outgas;
(2) suspending agent is added in the vegetable oil, take by weighing Rhizoma Paridis ethanol extract dry extract powder, mix with the vegetable oil that adds suspending agent, add antioxidant behind the mixing again, stir, room temperature leaves standstill;
(3) medicinal liquid for preparing is moved in a rolling capsule machine or the system machine, make soft capsule.
Water bath heating temperature in step (1) can be 85 ℃-95 ℃, and the best is 90 ℃.
Holding temperature in step (1) can be 60 ℃-80 ℃, and the best is 70 ℃.
GONGXUENING soft capsule of the present invention on the basis of conventional soft capsule preparation method to the kind of soft capsule adjuvant and principal agent and all temps in proportioning dosage and the preparation process through repeatedly experimentation is preferred, have reasonable mixture ratio, steady quality, carry, convenient drug administration, advantage that effectively stripping is fast, bioavailability is high; It is simple that the preparation of soft capsule method then has technology, is easy to control, and yield and quality is stable, the characteristics of no hazard residue.
The specific embodiment
The present invention is further illustrated below in conjunction with embodiment, and following each embodiment only is used to illustrate the present invention, but to not restriction of the present invention.
Embodiment one
Take by weighing extract dry extract powder 500g, the soybean oil 1200g, oily wax mixture 100g, gelatin 1000g, glycerol 350g, dibenzylatiooluene 50g, benzyl p-hydroxybenzoate 0.3g, the water 920g that contain diosgenin and pennogenin.Get gelatin and add entry while stirring, 85 ℃ of heating in water bath are treated that gelatin dissolves the back fully and adds glycerol, and are added benzyl p-hydroxybenzoate, stir 2 hours, keep 70 ℃ of set aside for use of temperature after the vacuumize degassing.Oily wax mixture is added in the soybean oil, get the extract dry extract after the pulverizing, mixes, stir adding dibenzylatiooluene, vacuumize degassing behind the mix homogeneously, stand for standby use under the room temperature with soybean oil.The medicinal liquid for preparing is moved in the system machine medicinal liquid bucket, drip and make soft capsule, promptly.
Embodiment two
Take by weighing the extract dry extract powder 500g, soybean oil 1600g, Cera Flava 130g, Polyethylene Glycol 1900g, glycerol 650g, dibenzylatiooluene 7.5g, benzyl p-hydroxybenzoate 0.5g, the water 1750g that contain diosgenin and pennogenin.Get gelatin and add entry while stirring, 87 ℃ of heating in water bath are treated that Polyethylene Glycol dissolves the back fully and adds glycerol, and are added benzyl p-hydroxybenzoate, stir 2 hours, keep 60 ℃ of set aside for use of temperature after the vacuumize degassing.Cera Flava is added in the soybean oil, get the extract dry extract after the pulverizing, mix, stir, add dibenzylatiooluene, vacuumize degassing behind the mix homogeneously, stand for standby use under the room temperature with soybean oil.The medicinal liquid for preparing is moved in the system machine medicinal liquid bucket, drip and make soft capsule, promptly.
Embodiment three
Take by weighing the extract dry extract powder 600g, Oleum Arachidis hypogaeae semen 1250g, Cera Flava 140g, gelatin 1350g, glycerol 470g, dibenzylatiooluene 6.5g, benzyl p-hydroxybenzoate 0.35g, the water 1200g that contain diosgenin and pennogenin.Get gelatin and add entry while stirring, 89 ℃ of heating in water bath are treated that gelatin dissolves the back fully and adds glycerol, and are added benzyl p-hydroxybenzoate and pigment, stir 1.5 hours, keep 65 ℃ of set aside for use of temperature after the vacuumize degassing.Cera Flava is added in the Oleum Arachidis hypogaeae semen, get the extract dry extract after the pulverizing, mix, stir, add dibenzylatiooluene, vacuumize degassing behind the mix homogeneously, stand for standby use under the room temperature with Oleum Arachidis hypogaeae semen.The medicinal liquid for preparing is moved in the rolling capsule machine medicinal liquid bucket, be pressed into soft capsule with mould, promptly.
Embodiment four
Take by weighing the extract dry extract powder 750g, soybean oil 1400g, Cera Flava 150g, gelatin 1450g, glycerol 470g, dibenzylatiooluene 7g, benzyl p-hydroxybenzoate 0.35g, the water 1300g that contain diosgenin and pennogenin.Get gelatin and add entry while stirring, 90 ℃ of heating in water bath are treated that gelatin dissolves the back fully and adds glycerol, and are added benzyl p-hydroxybenzoate, stir 2.5 hours, keep 75 ℃ of set aside for use of temperature behind the ultrasonic degas.Cera Flava is added in the soybean oil, get the extract dry extract after the pulverizing, mix, stir, add dibenzylatiooluene, ultrasonic degas behind the mix homogeneously, stand for standby use under the room temperature with soybean oil.The medicinal liquid for preparing is moved in the system machine medicinal liquid bucket, drip and make soft capsule, promptly.
Embodiment five
Take by weighing extract dry extract powder 950g, the soybean oil 1800g, oily wax mixture 140g, Polyethylene Glycol 1700g, glycerol 560g, dibenzylatiooluene 6g, benzyl p-hydroxybenzoate 0.4g, the water 1600g that contain diosgenin and pennogenin.Get gelatin and add entry while stirring, 93 ℃ of heating in water bath are treated that Polyethylene Glycol dissolves the back fully and adds glycerol, and are added benzyl p-hydroxybenzoate, stir 2 hours, keep 75 ℃ of set aside for use of temperature after the vacuumize degassing.Oily wax mixture is added in the soybean oil, get the extract dry extract after the pulverizing, mixes, stir adding dibenzylatiooluene, vacuumize degassing behind the mix homogeneously, stand for standby use under the room temperature with soybean oil.The medicinal liquid for preparing is moved in the rolling capsule machine medicinal liquid bucket, be pressed into soft capsule with mould, promptly.
Embodiment six
Take by weighing the extract dry extract powder 1000g, soybean oil 2000g, Cera Flava 270g, gelatin 3000g, glycerol 1100g, dibenzylatiooluene 10g, benzyl p-hydroxybenzoate 0.5g, the water 2700g that contain diosgenin and pennogenin.Get gelatin and add entry while stirring, 95 ℃ of heating in water bath are treated that gelatin dissolves the back fully and adds glycerol, and are added benzyl p-hydroxybenzoate and pigment, stir 1.5 hours, keep 70 ℃ of set aside for use of temperature after the vacuumize degassing.Cera Flava is added in the soybean oil, get the extract dry extract after the pulverizing, mix, stir, add dibenzylatiooluene, vacuumize degassing behind the mix homogeneously, stand for standby use under the room temperature with soybean oil.The medicinal liquid for preparing is moved in the system machine medicinal liquid bucket, drip and make soft capsule, promptly.
Embodiment seven
Take by weighing extract dry extract powder 800g, the soybean oil 1500g, oily wax mixture 130g, gelatin 1400g, glycerol 470g, dibenzylatiooluene 6g, benzyl p-hydroxybenzoate 0.3g, the water 1250g that contain diosgenin and pennogenin.Get gelatin and add entry while stirring, 85 ℃ of heating in water bath are treated that gelatin dissolves the back fully and adds glycerol, and are added benzyl p-hydroxybenzoate, stir 1.5 hours, keep 70 ℃ of set aside for use of temperature after the vacuumize degassing.Oily wax mixture is added in the soybean oil, get the extract dry extract after the pulverizing, mixes, stir adding dibenzylatiooluene, vacuumize degassing behind the mix homogeneously, stand for standby use under the room temperature with soybean oil.The medicinal liquid for preparing is moved in the system machine medicinal liquid bucket, drip and make soft capsule, promptly.
Embodiment eight
Take by weighing the extract dry extract powder 400g, soybean oil 950g, Cera Flava 110g, gelatin 1200g, glycerol 360g, dibenzylatiooluene 5.5g, benzyl p-hydroxybenzoate 0.35g, the water 1000g that contain diosgenin and pennogenin.Get gelatin and add entry while stirring, 90 ℃ of heating in water bath are treated that gelatin dissolves the back fully and adds glycerol, and are added benzyl p-hydroxybenzoate, stir 2 hours, keep 75 ℃ of set aside for use of temperature after the vacuumize degassing.Cera Flava is added in the soybean oil, add the extract dry extract after pulverizing, mix, stir, add dibenzylatiooluene, vacuumize degassing behind the mix homogeneously, stand for standby use under the room temperature with soybean oil.The medicinal liquid for preparing is moved in the system machine medicinal liquid bucket, drip and make soft capsule, promptly.
Embodiment nine
Take by weighing the extract dry extract powder 750g, Oleum Arachidis hypogaeae semen 1000g, Cera Flava 125g, gelatin 1500g, glycerol 550g, dibenzylatiooluene 7.5g, benzyl p-hydroxybenzoate 0.45g, the water 1300g that contain diosgenin and pennogenin.Get gelatin and add entry while stirring, 90 ℃ of heating in water bath treat that gelatin dissolves the back fully and adds glycerol,, and add benzyl p-hydroxybenzoate and an amount of pigment, stirred 2 hours, keep 70 ℃ of set aside for use of temperature behind the ultrasonic degas.Cera Flava is added in the Oleum Arachidis hypogaeae semen, get the extract dry extract after the pulverizing, mix, stir, add dibenzylatiooluene, ultrasonic degas behind the mix homogeneously, stand for standby use under the room temperature with Oleum Arachidis hypogaeae semen.The medicinal liquid for preparing is moved in the rolling capsule machine medicinal liquid bucket, be pressed into soft capsule with mould, promptly.
Claims (8)
1. a GONGXUENING soft capsule comprises capsule liquid, softgel shell, it is characterized in that they are made of following component and weight proportion:
Capsule liquid is made up of Rhizoma Paridis extract 10%-30%, adjuvant 70%-90%;
Softgel shell is made up of gelatin or Polyethylene Glycol 30%-60%, glycerol 0.8%-2%, additives 0.1%-0.5% and water 28-55%.
2. GONGXUENING soft capsule as claimed in claim 1 is characterized in that the weight proportion of each component is:
Capsule liquid is formed by Rhizoma Paridis extract 15%-25%, adjuvant 75%-85%;
Softgel shell is gelatin or Polyethylene Glycol 35%-50%, glycerol 1.0%-1.6%, additives 0.2%-0.4% and water 32%-48%.
3. GONGXUENING soft capsule as claimed in claim 1 is characterized in that the weight proportion of each component is:
Capsule liquid is formed by Rhizoma Paridis extract 18%-22%, adjuvant 78%-82%;
Softgel shell is gelatin or Polyethylene Glycol 40%-50%, glycerol 1.2%-1.4%, additives 0.25%-0.35% and water 38%-44%.
4. it is characterized in that as claim 1 or 2 or 3 described GONGXUENING soft capsules: described adjuvant is diluent, suspending agent, antioxidant, surfactant and antiseptic; Described additives are antiseptic, antioxidant.
5. GONGXUENING soft capsule as claimed in claim 4 is characterized in that: described diluent is a vegetable oil, and suspending agent is oily wax mixture, Cera Flava, and antioxidant is dibenzylatiooluene, and antiseptic is the benzyl p-hydroxybenzoate class.
6. GONGXUENING preparation of soft capsule method as claimed in claim 5 is characterized in that it comprises following process steps:
(1) gelatin, the fusion of water heating in water bath add glycerol, antiseptic, stir, and are incubated set aside for use after the vacuumize degassing;
(2) suspending agent is added in the vegetable oil, take by weighing the Rhizoma Paridis extract powder, mix with the vegetable oil that adds suspending agent, add antioxidant behind the mixing again, stir, room temperature leaves standstill;
(3) medicinal liquid for preparing is moved in a rolling capsule machine or the system machine, make soft capsule.
7. GONGXUENING preparation of soft capsule method as claimed in claim 6 is characterized in that: the water bath heating temperature in the step (1) is 85 ℃-95 ℃; Holding temperature is 60 ℃-80 ℃.
8. GONGXUENING preparation of soft capsule method as claimed in claim 7 is characterized in that: the water bath heating temperature in the step (1) is 90 ± 1 ℃; Holding temperature is 70 ± 1 ℃.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2003101078132A CN1528421A (en) | 2003-10-01 | 2003-10-01 | Soft capsule for tranquilizing uterine blood and preparing method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2003101078132A CN1528421A (en) | 2003-10-01 | 2003-10-01 | Soft capsule for tranquilizing uterine blood and preparing method thereof |
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| Publication Number | Publication Date |
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| CN1528421A true CN1528421A (en) | 2004-09-15 |
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| Application Number | Title | Priority Date | Filing Date |
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| CNA2003101078132A Pending CN1528421A (en) | 2003-10-01 | 2003-10-01 | Soft capsule for tranquilizing uterine blood and preparing method thereof |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100336502C (en) * | 2005-03-15 | 2007-09-12 | 北京科信必成医药科技发展有限公司 | Yunnan Manyleaf paris Rhizome extract ora disintegration tablet and its preparing process |
| CN100396288C (en) * | 2004-11-17 | 2008-06-25 | 云南白药集团股份有限公司 | Use of pennogenin in preparing medicines for enhance of hemopoietic function |
| CN1883493B (en) * | 2005-06-24 | 2010-05-05 | 云南白药集团股份有限公司 | Solid-state molecular dispersible preparation of pennogenin compound |
| CN101181288B (en) * | 2005-06-24 | 2010-06-02 | 云南白药集团股份有限公司 | Solid-state molecule disperse preparations of pennogenin series compounds |
| CN101856431A (en) * | 2010-06-02 | 2010-10-13 | 南京中医药大学 | Medicament for treating liver-kidney yin deficiency type anovulatory dysfunctional uterine bleeding, and preparation method and application thereof |
-
2003
- 2003-10-01 CN CNA2003101078132A patent/CN1528421A/en active Pending
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100396288C (en) * | 2004-11-17 | 2008-06-25 | 云南白药集团股份有限公司 | Use of pennogenin in preparing medicines for enhance of hemopoietic function |
| CN100336502C (en) * | 2005-03-15 | 2007-09-12 | 北京科信必成医药科技发展有限公司 | Yunnan Manyleaf paris Rhizome extract ora disintegration tablet and its preparing process |
| CN1883493B (en) * | 2005-06-24 | 2010-05-05 | 云南白药集团股份有限公司 | Solid-state molecular dispersible preparation of pennogenin compound |
| CN101181288B (en) * | 2005-06-24 | 2010-06-02 | 云南白药集团股份有限公司 | Solid-state molecule disperse preparations of pennogenin series compounds |
| CN101856431A (en) * | 2010-06-02 | 2010-10-13 | 南京中医药大学 | Medicament for treating liver-kidney yin deficiency type anovulatory dysfunctional uterine bleeding, and preparation method and application thereof |
| CN101856431B (en) * | 2010-06-02 | 2011-08-31 | 南京中医药大学 | Medicament for treating liver-kidney yin deficiency type anovulatory dysfunctional uterine bleeding, and preparation method and application thereof |
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