CN1528426A - Soft capsule and preparing method thereof - Google Patents
Soft capsule and preparing method thereof Download PDFInfo
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- CN1528426A CN1528426A CNA2003101078630A CN200310107863A CN1528426A CN 1528426 A CN1528426 A CN 1528426A CN A2003101078630 A CNA2003101078630 A CN A2003101078630A CN 200310107863 A CN200310107863 A CN 200310107863A CN 1528426 A CN1528426 A CN 1528426A
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Abstract
The present invention relates to a Chinese medicine Zhenhuang soft capsule and its preparation method. It is made up by using (wt%) 10%-30% of Chinese medicine powder preparation formed from 7 Chinese medicinal materials of pearl, bovine bezoar, notoginseng, scutellaria root, borneol, peppermint oil and pig's bile and 70%-90% of auxiliary material to form capsule liquor, using 30%-60% of gelating or polyethylene glycol, 1.0%-1.6% of glycerine, 0.2%-0.4% of additive and 32%-48% of water to form capsule material, and adopting drip-making and pressing process. Said invention is convenient for administration, can quickly obtain therapeutic effect, and is high in biological utilization rate and small in side effect.
Description
Technical field
That the present invention relates to is the preparation technology of Chinese medicine preparation, refers in particular to a kind of precious yellow preparation of soft capsule method of Chinese medicine preparation that is formed by Margarita, Calculus Bovis, Radix Notoginseng, Radix Scutellariae, Borneolum Syntheticum, Oleum menthae, Fel Sus domestica compatibility.
Background technology
Select the prescription of Chinese medicine Margarita, Calculus Bovis, Radix Notoginseng, Radix Scutellariae extract, Borneolum Syntheticum, Oleum menthae, Fel Sus domestica seven flavor compatibilities for use, Calculus Bovis heat-clearing and toxic substances removing wherein, waking up the patient from unconsciousness by dissipating phlegm clears away heart-fire, modern pharmacology confirms that it contains compositions such as cholic acid and deoxycholic acid, can reduce central nervous system's excitement, thereby produce calm, analgesic activity, to endogenous fire formation, diseases such as the laryngopharynx swelling and pain due to wind heat is disturbed outward, aphtha of the mouth and tongue, carbuncle furunculosis have the obvious treatment effect; The hemostasis of Radix Notoginseng energy, dissipating blood stasis, analgesic therapy are share with Calculus Bovis, are played heat-clearing and toxic substances removing altogether, the effect of pain in the detumescence; Margarita energy removing toxic substances and promoting granulation, diseases such as erosion that throat, dispute are swollen and ache have the healing of promotion effect; Baicaligenin that Radix Scutellariae is contained and baicaligenin and baicalin all can resist anaphylaxis edema and inflammation, resist the release of anaphylaxis medium, demonstrate the broad-spectrum antibacterial and anti-inflammation functions; Borneolum Syntheticum has strongly fragrant, clearing away heat to alleviate pain, the anticorrosion merit of loosing of having one's ideas straightened out, can be used for carbuncle skin ulcer furuncle, sore throat, pharyngalgia, aphtha, gingival swelling and pain etc. multiple burning hot due to disease; The heat clearing away of Fel Sus domestica antiperspirant, moisturize, detoxifcation, Borneolum Syntheticum and Fel Sus domestica also have bacteriostasis, to swelling and ache, the removing of pyretic toxicity has facilitation; Oleum menthae can dispelling wind heat, the sharp head, both strengthened the effect of principal agent, can further eliminate the burning hot heresy of still leaving in the body again, all medicines share and complement each other, heat-clearing and toxic substances removing altogether, the effect of reducing swelling and alleviating pain.But still have only capsule and tablet at present.
Summary of the invention
One object of the present invention is to provide a kind of Chinese medicine preparation precious yellow preparation of soft capsule method.
The present invention is implemented by following scheme.
The yellow soft capsule of a kind of treasure of the present invention comprises capsule liquid, softgel shell two parts, their component and weight proportion can for:
Capsule liquid is formed by principal agent 10%-30%, adjuvant 70%-90%;
Softgel shell is made up of gelatin or Polyethylene Glycol 30%-60%, glycerol 0.8%-2%, additives 0.1%-0.5% and water 28%-55%.
And the material component of capsule liquid principal agent and weight proportion (by weight) and preparation method are:
40 parts of Margaritas, 16 parts of Calculus Boviss, 32 parts of Radix Notoginseng, 20 parts of Radix Scutellariaes, 1 part of Borneolum Syntheticum, 2 parts of Oleum menthae, 20 parts of Fel Sus domestica;
Get Margarita, bovine calculus powder is broken into impalpable powder; get Radix Notoginseng powder and be broken into coarse powder; add the 70%-90% alcohol heating reflux and extract secondary, merge extractive liquid, reclaims ethanol to there not being the alcohol flavor; make dry extract; the Fel Sus domestica drying merges Radix Notoginseng extractum, the dry thing of Fel Sus domestica and Radix Scutellariae extract, is ground into fine powder; get above-mentioned powder and add Borneolum Syntheticum, Oleum menthae, promptly.
Also have precious yellow soft capsule component and weight proportion also can for:
Principal agent 15%-25%, the adjuvant 75%-85% of capsule liquid form;
Softgel shell is gelatin or Polyethylene Glycol 35%-50%, glycerol 1.0%-1.6%, additives 0.2%-0.4% and water 32%-48%.
The weight proportion of precious yellow soft capsule each component can also for:
Capsule liquid is formed by principal agent 18%-22%, adjuvant 78%-82%;
Softgel shell is that gelatin or Polyethylene Glycol 40%-50%, glycerol 1.2%-1.4%, additives are 0.25%-0.35% and water 38%-44%.
And above-mentioned adjuvant can be diluent, suspending agent, antioxidant, surfactant and antiseptic; Described additives are antiseptic, antioxidant.
Above-mentioned diluent can be one or more of edible vegetable oil, and suspending agent is oily wax mixture, Cera Flava, and antioxidant is dibenzylatiooluene, and antiseptic is benzyl p-hydroxybenzoate class, propylene glycol.
Precious yellow preparation of soft capsule method, it mainly comprises following process steps:
(1) gelatin, the dissolving of water heating in water bath add glycerol, antiseptic, stir, and are incubated set aside for use after the vacuumize degassing;
(2) suspending agent is added in the vegetable oil, take by weighing the principal agent powder that Margarita, Calculus Bovis, Radix Notoginseng, Radix Scutellariae extract, Borneolum Syntheticum, Oleum menthae, Fel Sus domestica are prepared into, the vegetable oil mixing with adding suspending agent adds antioxidant again, stirs, and room temperature leaves standstill;
(3) medicinal liquid for preparing is moved in a rolling capsule machine or the system machine, make soft capsule.
Advantage rapid-action, that bioavailability is high, side effect is little that soft capsule of the present invention has, preparation method is determining through repeatedly experimentation is preferred various baking temperatures, extraction time, supplementary product kind and addition in the preparation process on the basis of conventional pill preparation method, it is simple to have reasonable mixture ratio, no hazard residue, technology, be easy to control, the characteristics of constant product quality, but the existing dosage form of this product only has a kind of dosage form of capsule.
The specific embodiment
The present invention is further illustrated below in conjunction with embodiment, and following each embodiment only is used to illustrate the present invention, but to not restriction of the present invention.
Embodiment one
Take by weighing Margarita, Calculus Bovis, Radix Notoginseng, Radix Scutellariae, Borneolum Syntheticum, Oleum menthae, the Fel Sus domestica of recipe quantity; get Margarita, bovine calculus powder is broken into impalpable powder; get Radix Notoginseng powder and be broken into coarse powder; add 80% alcohol heating reflux and extract secondary, merge extractive liquid, reclaims ethanol to there not being the alcohol flavor; make dry extract; the Fel Sus domestica drying merges Radix Notoginseng extractum, the dry thing of Fel Sus domestica and Radix Scutellariae extract, is ground into fine powder.Get above-mentioned powder and add Borneolum Syntheticum, Oleum menthae, make fine powder.Get above-mentioned powder 300g, soybean oil 1200g, oily wax mixture 100g, gelatin 1000g, glycerol 350g, dibenzylatiooluene 50g, benzyl p-hydroxybenzoate 0.3g, the water 920g that contains prescription drug.Get gelatin and add entry while stirring, 85 ℃ of heating in water bath are treated that gelatin dissolves the back fully and adds glycerol, and are added benzyl p-hydroxybenzoate, stir 2 hours, keep 70 ℃ of set aside for use of temperature after the vacuumize degassing.Oily wax mixture is added in the soybean oil, get the drug powder after the pulverizing, mixes, stir adding dibenzylatiooluene, vacuumize degassing behind the mix homogeneously, stand for standby use under the room temperature with soybean oil.The medicinal liquid for preparing is moved in the system machine medicinal liquid bucket, drip and make soft capsule, promptly.
Embodiment two
Take by weighing Margarita, Calculus Bovis, Radix Notoginseng, Radix Scutellariae, Borneolum Syntheticum, Oleum menthae, the Fel Sus domestica of recipe quantity; get Margarita, bovine calculus powder is broken into impalpable powder; get Radix Notoginseng powder and be broken into coarse powder; add 75% alcohol heating reflux and extract secondary, merge extractive liquid, reclaims ethanol to there not being the alcohol flavor; make dry extract; the Fel Sus domestica drying merges Radix Notoginseng extractum, the dry thing of Fel Sus domestica and Radix Scutellariae extract, is ground into fine powder.Get above-mentioned powder and add Borneolum Syntheticum, Oleum menthae, make fine powder.Get above-mentioned powder 400g, Oleum Arachidis hypogaeae semen 1250g, Cera Flava 140g, gelatin 1350g, glycerol 470g, dibenzylatiooluene 6.5g, propylene glycol 0.35g, the water 1200g that contains prescription drug.Get gelatin and add entry while stirring, 89 ℃ of heating in water bath are treated that gelatin dissolves the back fully and adds glycerol, and are added propylene glycol, stir 1.5 hours, keep 65 ℃ of set aside for use of temperature after the vacuumize degassing.Oily wax mixture is added in the soybean oil, get the drug powder after the pulverizing, mixes, stir adding dibenzylatiooluene, vacuumize degassing behind the mix homogeneously, stand for standby use under the room temperature with soybean oil.The medicinal liquid for preparing is moved in the system machine medicinal liquid bucket, drip and make soft capsule, promptly.
Embodiment three
Take by weighing Margarita, Calculus Bovis, Radix Notoginseng, Radix Scutellariae, Borneolum Syntheticum, Oleum menthae, the Fel Sus domestica of recipe quantity; get Margarita, bovine calculus powder is broken into impalpable powder; get Radix Notoginseng powder and be broken into coarse powder; add 80% alcohol heating reflux and extract secondary, merge extractive liquid, reclaims ethanol to there not being the alcohol flavor; make dry extract; the Fel Sus domestica drying merges Radix Notoginseng extractum, the dry thing of Fel Sus domestica and Radix Scutellariae extract, is ground into fine powder.Get above-mentioned powder and add Borneolum Syntheticum, Oleum menthae, make fine powder.Get above-mentioned powder 300g, soybean oil 1200g, Cera Flava 130g, Polyethylene Glycol 1900g, glycerol 650g, dibenzylatiooluene 7.5g, benzyl p-hydroxybenzoate 0.5g, the water 1750g that contains prescription drug.Get gelatin and add entry while stirring, 87 ℃ of heating in water bath are treated that gelatin dissolves the back fully and adds glycerol, and are added benzyl p-hydroxybenzoate, stir 2 hours, keep 60 ℃ of set aside for use of temperature after the vacuumize degassing.Oily wax mixture is added in the soybean oil, get the drug powder after the pulverizing, mixes, stir adding dibenzylatiooluene, vacuumize degassing behind the mix homogeneously, stand for standby use under the room temperature with soybean oil.The medicinal liquid for preparing is moved in the system machine medicinal liquid bucket, drip and make soft capsule, promptly.
Embodiment four
Take by weighing Margarita, Calculus Bovis, Radix Notoginseng, Radix Scutellariae, Borneolum Syntheticum, Oleum menthae, the Fel Sus domestica of recipe quantity; get Margarita, bovine calculus powder is broken into impalpable powder; get Radix Notoginseng powder and be broken into coarse powder; add 85% alcohol heating reflux and extract secondary, merge extractive liquid, reclaims ethanol to there not being the alcohol flavor; make dry extract; the Fel Sus domestica drying merges Radix Notoginseng extractum, the dry thing of Fel Sus domestica and Radix Scutellariae extract, is ground into fine powder.Get above-mentioned powder 250g, soybean oil 900g, Cera Flava 150g, gelatin 1450g, glycerol 470g, dibenzylatiooluene 7g, benzyl p-hydroxybenzoate 0.35g, the water 1300g that contains prescription drug.Get gelatin and add entry while stirring, 90 ℃ of heating in water bath are treated that gelatin dissolves the back fully and adds glycerol, and are added benzyl p-hydroxybenzoate, stir 2.5 hours, keep 75 ℃ of set aside for use of temperature after the vacuumize degassing.Oily wax mixture is added in the soybean oil, get the drug powder after the pulverizing, mixes, stir adding dibenzylatiooluene, vacuumize degassing behind the mix homogeneously, stand for standby use under the room temperature with soybean oil.The medicinal liquid for preparing is moved in the encapsulating machine medicinal liquid bucket, be pressed into soft capsule with mould, promptly.
Embodiment five
Take by weighing Margarita, Calculus Bovis, Radix Notoginseng, Radix Scutellariae, Borneolum Syntheticum, Oleum menthae, the Fel Sus domestica of recipe quantity; get Margarita, bovine calculus powder is broken into impalpable powder; get Radix Notoginseng powder and be broken into coarse powder; add 78% alcohol heating reflux and extract secondary, merge extractive liquid, reclaims ethanol to there not being the alcohol flavor; make dry extract; the Fel Sus domestica drying merges Radix Notoginseng extractum, the dry thing of Fel Sus domestica and Radix Scutellariae extract, is ground into fine powder.Get above-mentioned powder and add Borneolum Syntheticum, Oleum menthae, make fine powder.Get above-mentioned powder 600g, soybean oil 2000g, Cera Flava 270g, gelatin 3000g, glycerol 1100g, dibenzylatiooluene 10g, benzyl p-hydroxybenzoate 0.5g, the water 2700g that contains prescription drug.Get gelatin and add entry while stirring, 95 ℃ of heating in water bath are treated that gelatin dissolves the back fully and adds glycerol, and are added benzyl p-hydroxybenzoate, stir 1.5 hours, keep 70 ℃ of set aside for use of temperature after the vacuumize degassing.Oily wax mixture is added in the soybean oil, get the drug powder after the pulverizing, mixes, stir adding dibenzylatiooluene, vacuumize degassing behind the mix homogeneously, stand for standby use under the room temperature with soybean oil.The medicinal liquid for preparing is moved in the encapsulating machine medicinal liquid bucket, be pressed into soft capsule with mould, promptly.
Embodiment six
Take by weighing Margarita, Calculus Bovis, Radix Notoginseng, Radix Scutellariae, Borneolum Syntheticum, Oleum menthae, the Fel Sus domestica of recipe quantity; get Margarita, bovine calculus powder is broken into impalpable powder; get Radix Notoginseng powder and be broken into coarse powder; add 80% alcohol heating reflux and extract secondary, merge extractive liquid, reclaims ethanol to there not being the alcohol flavor; make dry extract; the Fel Sus domestica drying merges Radix Notoginseng extractum, the dry thing of Fel Sus domestica and Radix Scutellariae extract, is ground into fine powder.Get above-mentioned powder and add Borneolum Syntheticum, Oleum menthae, make fine powder.Get above-mentioned powder 400g, soybean oil 1500g, oily wax mixture 130g, gelatin 1400g, glycerol 470g, dibenzylatiooluene 6g, propylene glycol 0.3g, the water 1250g that contains prescription drug.Get gelatin and add entry while stirring, 85 ℃ of heating in water bath are treated that gelatin dissolves the back fully and adds glycerol, and are added propylene glycol, stir 1.5 hours, keep 70 ℃ of set aside for use of temperature after the vacuumize degassing.Oily wax mixture is added in the soybean oil, get the drug powder after the pulverizing, mixes, stir adding dibenzylatiooluene, vacuumize degassing behind the mix homogeneously, stand for standby use under the room temperature with soybean oil.The medicinal liquid for preparing is moved in the system machine medicinal liquid bucket, drip and make soft capsule, promptly.
Claims (6)
1. the yellow soft capsule of treasure comprises capsule liquid, softgel shell, it is characterized in that they are made of following component and weight proportion:
Capsule liquid is formed by principal agent 10%-30%, adjuvant 70%-90%;
Softgel shell is made up of gelatin or Polyethylene Glycol 30%-60%, glycerol 0.8%-2%, additives 0.1%-0.5% and water 28%-55%.
Described principal agent (by weight) is got 40 parts of Margaritas, Calculus Bovis is ground into impalpable powder for 16 parts; get Radix Notoginseng and be ground into coarse powder for 32 parts; add alcohol heating reflux and extract secondary, merge extractive liquid, reclaims ethanol to there not being the alcohol flavor; make dry extract; 20 parts of dryings of Fel Sus domestica merge 20 parts of Radix Notoginseng extractum, the dry thing of Fel Sus domestica and Radix Scutellariae extracts, are ground into fine powder; add 1 part of Borneolum Syntheticum, 2 parts of Oleum menthae again, make.
2. the yellow soft capsule of treasure as claimed in claim 1 is characterized in that the weight proportion of each component is:
Principal agent 15%-25%, the adjuvant 75%-85% of capsule liquid form;
Softgel shell is gelatin or Polyethylene Glycol 35%-50%, glycerol 1.0%-1.6%, additives 0.2%-0.4% and water 32%-48%.
3. the yellow soft capsule of treasure as claimed in claim 1 is characterized in that the weight proportion of each component is:
Capsule liquid is formed by principal agent 18%-22%, adjuvant 78%-82%;
Softgel shell is that gelatin or Polyethylene Glycol 40%-50%, glycerol 1.2%-1.4%, additives are 0.25%-0.35% and water 38%-44%.
4. it is characterized in that as claim 1 or the yellow soft capsule of 2 or 3 described treasure: described adjuvant is diluent, suspending agent, antioxidant, surfactant and antiseptic; Described additives are antiseptic, antioxidant.
5. the yellow soft capsule of treasure as claimed in claim 4, it is characterized in that: described diluent is one or more of usefulness vegetable oil, suspending agent is oily wax mixture, Cera Flava, and antioxidant is dibenzylatiooluene, and antiseptic is benzyl p-hydroxybenzoate class, propylene glycol.
6. the yellow preparation of soft capsule method of treasure as claimed in claim 5 is characterized in that it comprises following process steps:
(1) gelatin, the dissolving of water heating in water bath add glycerol, antiseptic, stir, and are incubated set aside for use after the vacuumize degassing;
(2) suspending agent is added in the vegetable oil, take by weighing the principal agent powder that Margarita, Calculus Bovis, Radix Notoginseng, Radix Scutellariae extract, Borneolum Syntheticum, Oleum menthae, Fel Sus domestica are prepared into, the vegetable oil mixing with adding suspending agent adds antioxidant again, stirs, and room temperature leaves standstill;
(3) medicinal liquid for preparing is moved in a rolling capsule machine or the system machine, make soft capsule.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2003101078630A CN1528426A (en) | 2003-10-08 | 2003-10-08 | Soft capsule and preparing method thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CNA2003101078630A CN1528426A (en) | 2003-10-08 | 2003-10-08 | Soft capsule and preparing method thereof |
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| CN1528426A true CN1528426A (en) | 2004-09-15 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101697998B (en) * | 2009-06-13 | 2012-01-11 | 浙江天一堂集团有限公司 | Zhenhuang tablet for treating sore throat and ulcer and sore furuncle and preparation method thereof |
-
2003
- 2003-10-08 CN CNA2003101078630A patent/CN1528426A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101697998B (en) * | 2009-06-13 | 2012-01-11 | 浙江天一堂集团有限公司 | Zhenhuang tablet for treating sore throat and ulcer and sore furuncle and preparation method thereof |
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