CN1491708A - Nephritis soft capsule and its preparing method - Google Patents
Nephritis soft capsule and its preparing method Download PDFInfo
- Publication number
- CN1491708A CN1491708A CNA031420893A CN03142089A CN1491708A CN 1491708 A CN1491708 A CN 1491708A CN A031420893 A CNA031420893 A CN A031420893A CN 03142089 A CN03142089 A CN 03142089A CN 1491708 A CN1491708 A CN 1491708A
- Authority
- CN
- China
- Prior art keywords
- herba
- capsule
- nephritis
- soft capsule
- gelatin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Medicinal Preparation (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The soft astragalus capsule for treating nephritis has medicine liquid comprising medicine extractive of common goldenrod herb, European verbena, cogongrass rhizome, plantain herb, bottle gourd shell and willowleaf swallowwort rhizome in 10-30 wt% and supplementary material in 70-90 wt%; and capsule shell comprising gelatin or polyglycol in 30-60 wt%, glycerin in 0.8-2 wt%, antioxidant and preservative 0.1-0.5 wt% and water 28-55 wt%, and is prepared through dropping or pressing. The soft capsule has fast acting, high biological utilization and less side effect, and the preparation process is simple, easy to control, stable in product quality and without harmful residue.
Description
Technical field
What the present invention relates to is a kind of Chinese patent medicine novel formulation and preparation method thereof, and referring in particular to a kind of extract with Chinese herbal medicine Herba Solidaginis, Herba Verbenae, Rhizoma Imperatae, Herba Plantaginis, calabash shell, Rhizoma Cynanchi Stauntonii Six-element medicine is nephritis soft capsule of raw material and preparation method thereof.
Background technology
Nephropathy is common frequently-occurring disease, adds up according to relevant data: acute nephritis patient accounts for the 1%-2% of world population sum, national annual acute nephritis number of the infected about 2,000 ten thousand.The specific medicament of these two kinds of diseases of current treatment is actually rare.Decocted with water secondary each two hours by Six-element medicine Herba Solidaginis 1080g, Herba Verbenae 270g, Rhizoma Imperatae 540g, Herba Plantaginis 540g, calabash shell 270g, Rhizoma Cynanchi Stauntonii 270g, collecting decoction leaves standstill, and filters.Filtrate is condensed into the thick paste shape, drying is made granule, is pressed into 1000, coating and kidney inflammation tablets, the effect that it has blood circulation promoting and blood stasis dispelling, inducing diuresis to remove edema is mainly used in uremia, the nephrotic syndrome, the treatment of acute and chronic nephritis, to the edema that the current domestic associated kidney disease that does not still have good medicine control causes, hematuria, albuminuretic treatment has unique effect.Original dosage form only is a tablet.
Summary of the invention
The object of the present invention is to provide a kind of is the nephritis soft capsule of raw material with Chinese herbal medicine Herba Solidaginis, Herba Verbenae, Rhizoma Imperatae, Herba Plantaginis, calabash shell, Rhizoma Cynanchi Stauntonii extract.
It is the nephritis preparation of soft capsule method of raw material with Chinese herbal medicine Herba Solidaginis, Herba Verbenae, Rhizoma Imperatae, Herba Plantaginis, calabash shell, Rhizoma Cynanchi Stauntonii extract that another object of the present invention provides a kind of
The present invention is implemented by following scheme.
A kind of nephritis soft capsule of the present invention, comprise capsule liquid, softgel shell, capsule liquid principal agent is (to measure 2 hours for 8 times for the first time after getting 108 parts of (by weight) Herba Solidaginiss, 27 parts of Herba Verbenae, 54 parts of Rhizoma Imperataes, 54 parts of Herba Plantaginiss, 27 parts on calabash shell, 27 parts of processes of Rhizoma Cynanchi Stauntonii water extracted twice, measured 1.5 hours for 6 times for the second time), collecting decoction, be concentrated into half, with 95% ethanol precipitate with ethanol, standing over night, filter, filtrate is condensed into drying under reduced pressure behind the thick extractum, wear into powder and form, and capsule liquid and softgel shell is made of following component and weight proportion:
By weight percentage
Capsule liquid is formed by containing Herba Solidaginis, Herba Verbenae, Rhizoma Imperatae, Herba Plantaginis, calabash shell, Rhizoma Cynanchi Stauntonii extract dry extract powder 10%-30% and adjuvant 70%-90%;
Softgel shell is made up of gelatin or Polyethylene Glycol 30%-60%, glycerol 0.8%-2%, additives 0.1%-0.5% and water 28%-55%.
And the weight proportion of each component can be preferably:
By weight percentage
Capsule liquid is formed by containing Herba Solidaginis, Herba Verbenae, Rhizoma Imperatae, Herba Plantaginis, calabash shell, Rhizoma Cynanchi Stauntonii extract dry extract powder 15%-25% and adjuvant 75%-85%;
Softgel shell is gelatin or Polyethylene Glycol 35%-50%, glycerol 1.0%-1.6%, additives 0.2%-0.4% and water 32%-48%.
Weight proportion the best of each component is:
By weight percentage
Capsule liquid is formed by containing Herba Solidaginis, Herba Verbenae, Rhizoma Imperatae, Herba Plantaginis, calabash shell, Rhizoma Cynanchi Stauntonii extract dry extract powder 18%-22% and adjuvant 78%-82%;
Softgel shell is that gelatin or Polyethylene Glycol 40%-50%, glycerol 1.2%-1.4%, additives are 0.25%-0.35% and water 38%-44%.
The Chinese medicinal soft capsule of the prophylactic treatment flu that above-mentioned composition constitutes, described adjuvant can be diluent, suspending agent, antioxidant, surfactant and antiseptic; Described additives can be antiseptic, antioxidant.
And described diluent is preferably vegetable oil, and suspending agent is preferably oily wax mixture, Cera Flava, and antioxidant is preferably dibenzylatiooluene, and antiseptic is preferably benzyl p-hydroxybenzoate class, propylene glycol.
Nephritis preparation of soft capsule method of the present invention, it mainly comprises following process steps:
(1) gelatin, the dissolving of water heating in water bath mix mutually with glycerol, add antiseptic again, stir, and are incubated set aside for use after the vacuum outgas;
(2) suspending agent is added in the vegetable oil, take by weighing and contain Herba Solidaginis, Herba Verbenae, Rhizoma Imperatae, Herba Plantaginis, calabash shell, Rhizoma Cynanchi Stauntonii extract dry extract powder, mix with the vegetable oil that adds suspending agent, add antioxidant behind the mixing again, stir, room temperature leaves standstill;
(3) medicinal liquid for preparing is moved in a rolling capsule machine or the system machine, make soft capsule.
Water bath heating temperature in step (1) can be 85 ℃-95 ℃, and the best is 90 ℃.
Holding temperature in step (1) can be 60 ℃-80 ℃, and the best is 70 ℃.
Nephritis soft capsule of the present invention on the basis of conventional soft capsule preparation method to the kind of soft capsule adjuvant and principal agent and all temps in proportioning dosage and the preparation process through repeatedly experimentation is preferred, have reasonable mixture ratio, steady quality, carry, convenient drug administration, advantage that effectively stripping is fast, bioavailability is high; It is simple that the preparation of soft capsule method then has technology, is easy to control, constant product quality, the characteristics of no hazard residue.
The specific embodiment
The present invention is further illustrated below in conjunction with embodiment, and following each embodiment only is used to illustrate the present invention, but to not restriction of the present invention.
Embodiment one
(8 times of amounts are 2 hours for the first time after through the water extracted twice to take by weighing Herba Solidaginis, Herba Verbenae, Rhizoma Imperatae, Herba Plantaginis, calabash shell, Rhizoma Cynanchi Stauntonii by recipe quantity, measured 1.5 hours for 6 times for the second time), collecting decoction, be concentrated into half, with 95% ethanol precipitate with ethanol, standing over night, filter, filtrate is condensed into drying under reduced pressure behind the thick extractum, wears into fine powder.Take by weighing aforesaid extract dry extract powder 300g, soybean oil 1200g, oily wax mixture 100g, gelatin 1000g, glycerol 350g, dibenzylatiooluene 50g, benzyl p-hydroxybenzoate 0.3g, water 920g.Get gelatin and add entry while stirring, 85 ℃ of heating in water bath are treated that gelatin dissolves the back fully and adds glycerol, and are added benzyl p-hydroxybenzoate, stir 2 hours, keep 70 ℃ of set aside for use of temperature after the vacuumize degassing.Oily wax mixture is added in the soybean oil, get the extract dry extract after the pulverizing, mixes, stir adding dibenzylatiooluene, vacuumize degassing behind the mix homogeneously, stand for standby use under the room temperature with soybean oil.The medicinal liquid for preparing is moved in the system machine medicinal liquid bucket, drip and make soft capsule, promptly.
Embodiment two
Take by weighing aforesaid extract dry extract powder 300g, soybean oil 1600g, Cera Flava 130g, Polyethylene Glycol 1900g, glycerol 650g, dibenzylatiooluene 7.5g, benzyl p-hydroxybenzoate 0.5g, water 1750g.Get gelatin and add entry while stirring, 87 ℃ of heating in water bath are treated that Polyethylene Glycol dissolves the back fully and adds glycerol, and are added benzyl p-hydroxybenzoate, stir 2 hours, keep 60 ℃ of set aside for use of temperature after the vacuumize degassing.Cera Flava is added in the soybean oil, get the extract dry extract after the pulverizing, mix, stir, add dibenzylatiooluene, vacuumize degassing behind the mix homogeneously, stand for standby use under the room temperature with soybean oil.The medicinal liquid for preparing is moved in the system machine medicinal liquid bucket, drip and make soft capsule, promptly.
Embodiment three
Take by weighing aforesaid extract dry extract powder 400g, Oleum Arachidis hypogaeae semen 1250g, Cera Flava 140g, gelatin 1350g, glycerol 470g, dibenzylatiooluene 6.5g, propylene glycol 0.35g, water 1200g.Get gelatin and add entry while stirring, 89 ℃ of heating in water bath are treated that gelatin dissolves the back fully and adds glycerol, and are added propylene glycol and pigment, stir 1.5 hours, keep 65 ℃ of set aside for use of temperature after the vacuumize degassing.Cera Flava is added in the Oleum Arachidis hypogaeae semen, get the extract dry extract after the pulverizing, mix, stir, add dibenzylatiooluene, vacuumize degassing behind the mix homogeneously, stand for standby use under the room temperature with Oleum Arachidis hypogaeae semen.The medicinal liquid for preparing is moved in the rolling capsule machine medicinal liquid bucket, be pressed into soft capsule with mould, promptly.
Embodiment four
Take by weighing aforesaid extract dry extract powder 250g, soybean oil 1400g, Cera Flava 150g, gelatin 1450g, glycerol 470g, dibenzylatiooluene 7g, benzyl p-hydroxybenzoate 0.35g, water 1300g.Get gelatin and add entry while stirring, 90 ℃ of heating in water bath are treated that gelatin dissolves the back fully and adds glycerol, and are added benzyl p-hydroxybenzoate, stir 2.5 hours, keep 75 ℃ of set aside for use of temperature behind the ultrasonic degas.Cera Flava is added in the soybean oil, get the extract dry extract after the pulverizing, mix, stir, add dibenzylatiooluene, ultrasonic degas behind the mix homogeneously, stand for standby use under the room temperature with soybean oil.The medicinal liquid for preparing is moved in the system machine medicinal liquid bucket, drip and make soft capsule, promptly.
Embodiment five
Take by weighing aforesaid extract dry extract powder 450g, soybean oil 1800g, oily wax mixture 140g, Polyethylene Glycol 1700g, glycerol 560g, dibenzylatiooluene 6g, benzyl p-hydroxybenzoate 0.4g, water 1600g.Get gelatin and add entry while stirring, 93 ℃ of heating in water bath are treated that Polyethylene Glycol dissolves the back fully and adds glycerol, and are added benzyl p-hydroxybenzoate, stir 2 hours, keep 75 ℃ of set aside for use of temperature after the vacuumize degassing.Oily wax mixture is added in the soybean oil, get the extract dry extract after the pulverizing, mixes, stir adding dibenzylatiooluene, vacuumize degassing behind the mix homogeneously, stand for standby use under the room temperature with soybean oil.The medicinal liquid for preparing is moved in the rolling capsule machine medicinal liquid bucket, be pressed into soft capsule with mould, promptly.
Embodiment six
Take by weighing aforesaid extract dry extract powder 600g, soybean oil 2000g, Cera Flava 270g, gelatin 3000g, glycerol 1100g, dibenzylatiooluene 10g, benzyl p-hydroxybenzoate 0.5g, water 2700g.Get gelatin and add entry while stirring, 95 ℃ of heating in water bath are treated that gelatin dissolves the back fully and adds glycerol, and are added benzyl p-hydroxybenzoate and pigment, stir 1.5 hours, keep 70 ℃ of set aside for use of temperature after the vacuumize degassing.Cera Flava is added in the soybean oil, get the extract dry extract after the pulverizing, mix, stir, add dibenzylatiooluene, vacuumize degassing behind the mix homogeneously, stand for standby use under the room temperature with soybean oil.The medicinal liquid for preparing is moved in the system machine medicinal liquid bucket, drip and make soft capsule, promptly.
Embodiment seven
Take by weighing aforesaid extract dry extract powder 400g, soybean oil 1500g, oily wax mixture 130g, gelatin 1400g, glycerol 470g, dibenzylatiooluene 6g, propylene glycol 0.3g, water 1250g.Get gelatin and add entry while stirring, 85 ℃ of heating in water bath are treated that gelatin dissolves the back fully and adds glycerol, and are added propylene glycol, stir 1.5 hours, keep 70 ℃ of set aside for use of temperature after the vacuumize degassing.Oily wax mixture is added in the soybean oil, get the extract dry extract after the pulverizing, mixes, stir adding dibenzylatiooluene, vacuumize degassing behind the mix homogeneously, stand for standby use under the room temperature with soybean oil.The medicinal liquid for preparing is moved in the system machine medicinal liquid bucket, drip and make soft capsule, promptly.
Embodiment eight
Take by weighing aforesaid extract dry extract powder 200g, soybean oil 950g, Cera Flava 110g, gelatin 1200g, glycerol 360g, dibenzylatiooluene 5.5g, benzyl p-hydroxybenzoate 0.35g, water 1000g.Get gelatin and add entry while stirring, 90 ℃ of heating in water bath are treated that gelatin dissolves the back fully and adds glycerol, and are added benzyl p-hydroxybenzoate, stir 2 hours, keep 75 ℃ of set aside for use of temperature after the vacuumize degassing.Cera Flava is added in the soybean oil, add the extract dry extract after pulverizing, mix, stir, add dibenzylatiooluene, vacuumize degassing behind the mix homogeneously, stand for standby use under the room temperature with soybean oil.The medicinal liquid for preparing is moved in the system machine medicinal liquid bucket, drip and make soft capsule, promptly.
Embodiment nine
Take by weighing aforesaid extract dry extract powder 250g, Oleum Arachidis hypogaeae semen 1000g, Cera Flava 125g, gelatin 1500g, glycerol 550g, dibenzylatiooluene 7.5g, benzyl p-hydroxybenzoate 0.45g, water 1300g.Get gelatin and add entry while stirring, 90 ℃ of heating in water bath treat that gelatin dissolves the back fully and adds glycerol,, and add benzyl p-hydroxybenzoate and an amount of pigment, stirred 2 hours, keep 70 ℃ of set aside for use of temperature behind the ultrasonic degas.Cera Flava is added in the Oleum Arachidis hypogaeae semen, get the extract dry extract after the pulverizing, mix, stir, add dibenzylatiooluene, ultrasonic degas behind the mix homogeneously, stand for standby use under the room temperature with Oleum Arachidis hypogaeae semen.The medicinal liquid for preparing is moved in the rolling capsule machine medicinal liquid bucket, be pressed into soft capsule with mould, promptly.
Claims (7)
1. nephritis soft capsule, comprise capsule liquid, softgel shell, capsule liquid principal agent is to get 108 parts of (by weight) Herba Solidaginiss, 27 parts of Herba Verbenae, 54 parts of Rhizoma Imperataes, 54 parts of Herba Plantaginiss, 27 parts on calabash shell, Rhizoma Cynanchi Stauntonii to carry through water for 27 parts, concentrate, precipitate with ethanol leaves standstill, filter, after concentrating, flour forms, and it is characterized in that they are made of following component and weight proportion:
Capsule liquid principal agent is formed by containing Herba Solidaginis, Herba Verbenae, Rhizoma Imperatae, Herba Plantaginis, calabash shell, Rhizoma Cynanchi Stauntonii extract 10%-30%, adjuvant 70%-90%;
Softgel shell is made up of gelatin or Polyethylene Glycol 30%-60%, glycerol 0.8%-2%, additives 0.1%-0.5% and water 28%-55%.
2. nephritis soft capsule as claimed in claim 1 is characterized in that the weight proportion of each component is preferably:
Capsule liquid principal agent is formed by Herba Solidaginis, Herba Verbenae, Rhizoma Imperatae, Herba Plantaginis, calabash shell, Rhizoma Cynanchi Stauntonii extract 15%-25%, adjuvant 75%-85%;
Softgel shell is gelatin or Polyethylene Glycol 35%-50%, glycerol 1.0%-1.6%, additives 0.2%-0.4% and water 32%-48%.
3. nephritis soft capsule as claimed in claim 1 is characterized in that weight proportion the best of each component is:
Capsule liquid principal agent is formed by Herba Solidaginis, Herba Verbenae, Rhizoma Imperatae, Herba Plantaginis, calabash shell, Rhizoma Cynanchi Stauntonii extract 18%-22%, adjuvant 78%-82%;
Softgel shell is that gelatin or Polyethylene Glycol 40%-50%, glycerol 1.2%-1.4%, additives are 0.25%-0.35% and water 38%-44%.
4. it is characterized in that as claim 1 or 2 or 3 described nephritis soft capsules: described adjuvant is diluent, suspending agent, antioxidant, surfactant and antiseptic; Described additives are antiseptic, antioxidant.
5. nephritis soft capsule as claimed in claim 4 is characterized in that: described diluent is a vegetable oil, and suspending agent is oily wax mixture, Cera Flava, and antioxidant is dibenzylatiooluene, and antiseptic is benzyl p-hydroxybenzoate class, propylene glycol.
6. nephritis preparation of soft capsule method as claimed in claim 7 is characterized in that it comprises following process steps:
(1) gelatin, the dissolving of water heating in water bath add glycerol, antiseptic, stir, and are incubated set aside for use after the vacuumize degassing;
(2) suspending agent is added in the vegetable oil, take by weighing Herba Solidaginis, Herba Verbenae, Rhizoma Imperatae, Herba Plantaginis, calabash shell, Rhizoma Cynanchi Stauntonii extract powder, mix with the vegetable oil that adds suspending agent, add antioxidant behind the mixing again, stir, room temperature leaves standstill;
(3) medicinal liquid for preparing is moved in a rolling capsule machine or the system machine, make soft capsule.
7. nephritis preparation of soft capsule method as claimed in claim 1 is characterized in that: the water bath heating temperature in the step (1) is 85 ℃-95 ℃, and the best is 90 ℃; Holding temperature is 60 ℃-80 ℃, and optimum temperature is 70 ℃.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA031420893A CN1491708A (en) | 2003-08-02 | 2003-08-02 | Nephritis soft capsule and its preparing method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA031420893A CN1491708A (en) | 2003-08-02 | 2003-08-02 | Nephritis soft capsule and its preparing method |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1491708A true CN1491708A (en) | 2004-04-28 |
Family
ID=34240358
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNA031420893A Pending CN1491708A (en) | 2003-08-02 | 2003-08-02 | Nephritis soft capsule and its preparing method |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1491708A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104623361A (en) * | 2015-01-14 | 2015-05-20 | 青岛市市立医院 | Pharmaceutical composition for treating chronic renal failure and application of pharmaceutical composition |
| CN111467442A (en) * | 2020-04-11 | 2020-07-31 | 中国农业大学 | Medicinal preparation for treating canine urinary tract inflammation and preparation method thereof |
-
2003
- 2003-08-02 CN CNA031420893A patent/CN1491708A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104623361A (en) * | 2015-01-14 | 2015-05-20 | 青岛市市立医院 | Pharmaceutical composition for treating chronic renal failure and application of pharmaceutical composition |
| CN104623361B (en) * | 2015-01-14 | 2018-06-05 | 青岛市市立医院 | A kind of medical composition and its use for treating chronic renal failure |
| CN111467442A (en) * | 2020-04-11 | 2020-07-31 | 中国农业大学 | Medicinal preparation for treating canine urinary tract inflammation and preparation method thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN101612362B (en) | Complex preparation for regulating lipid and preventing and curing heart cerebrovascular diseases and preparation method thereof | |
| CN1491706A (en) | Soft capsule for removing blood stasis in chest and its preparing method | |
| CN1491708A (en) | Nephritis soft capsule and its preparing method | |
| CN111450171B (en) | Wuzi Yanzong soft capsule and preparation method thereof | |
| CN104606628A (en) | Face-nourishing, beautifying and chloasma-removing traditional Chinese medicine composition | |
| CN1528421A (en) | Soft capsule for tranquilizing uterine blood and preparing method thereof | |
| CN1954872A (en) | Traditional Chinese medicine composite and its preparation method | |
| CN1491707A (en) | Pulse-activating astragalus root soft capsule and its preparing method | |
| CN105311328A (en) | Traditional Chinese medicine composition for treating gynecological inflammation and application thereof | |
| CN1528425A (en) | Soft capsule and preparing method thereof | |
| CN1686112B (en) | Use of cnidicin and preparation used for treating fatty liver | |
| CN1943755A (en) | A Chinese traditional medicinal composition for treatment of hypertension and its preparation method | |
| CN1490041A (en) | Cottonrose hibiscus leaf and magnolia bark containing medicines against catch-cold and preparation thereof | |
| CN117959387B (en) | Traditional Chinese medicine composition for treating hypertension, preparation method and application | |
| CN1528422A (en) | Motherwort soft capsule and preparing method thereof | |
| CN106924405A (en) | A kind of composition for preventing and treating mastitis for milk cows and preparation method thereof | |
| CN1528423A (en) | Flos chrysanthemi indici and peal soft capsule for bringing high blood pressure down and its preparing method | |
| CN101554399B (en) | Psoralea corylifolial extract with immunologic enhancement and application thereof | |
| CN1085796A (en) | The oral Chinese medicine compositions of treatment cancer | |
| CN1672719A (en) | Application of fleece flower root in preparing medicine for treating fatty liver | |
| CN1299670C (en) | Capsules for eliminating embolism and their preparation | |
| CN1730017A (en) | Mighty soft capsule of gastrodia tuber and eucommia and its preparation process | |
| CN1781520A (en) | Method for preparing Qingkailing preparation | |
| CN101269130A (en) | Chinese medicinal composition for treating hemorrhoid | |
| CN1528424A (en) | Soft capsule and preparing method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |