CN1528270A - Chinese medicine cataplasm matrix and preparing technique thereof - Google Patents
Chinese medicine cataplasm matrix and preparing technique thereof Download PDFInfo
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- CN1528270A CN1528270A CNA200310105804XA CN200310105804A CN1528270A CN 1528270 A CN1528270 A CN 1528270A CN A200310105804X A CNA200310105804X A CN A200310105804XA CN 200310105804 A CN200310105804 A CN 200310105804A CN 1528270 A CN1528270 A CN 1528270A
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- chinese medicine
- substrate
- water
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- 239000003814 drug Substances 0.000 title claims abstract description 48
- 238000000034 method Methods 0.000 title abstract description 18
- 239000011159 matrix material Substances 0.000 title abstract 5
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 29
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 18
- 229920002125 Sokalan® Polymers 0.000 claims abstract description 12
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 claims abstract description 12
- VTHJTEIRLNZDEV-UHFFFAOYSA-L magnesium dihydroxide Chemical compound [OH-].[OH-].[Mg+2] VTHJTEIRLNZDEV-UHFFFAOYSA-L 0.000 claims abstract description 12
- 229910001862 magnesium hydroxide Inorganic materials 0.000 claims abstract description 12
- 239000000347 magnesium hydroxide Substances 0.000 claims abstract description 12
- 239000004584 polyacrylic acid Substances 0.000 claims abstract description 12
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims abstract description 12
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims abstract description 12
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims abstract description 12
- AXTGDCSMTYGJND-UHFFFAOYSA-N 1-dodecylazepan-2-one Chemical compound CCCCCCCCCCCCN1CCCCCC1=O AXTGDCSMTYGJND-UHFFFAOYSA-N 0.000 claims abstract description 10
- 238000002156 mixing Methods 0.000 claims abstract description 3
- 239000000758 substrate Substances 0.000 claims description 26
- 239000000203 mixture Substances 0.000 claims description 14
- 238000005516 engineering process Methods 0.000 claims description 9
- 239000000463 material Substances 0.000 claims description 8
- 238000003756 stirring Methods 0.000 claims description 6
- 239000007864 aqueous solution Substances 0.000 claims description 3
- 239000000084 colloidal system Substances 0.000 claims description 3
- 229920000642 polymer Polymers 0.000 claims description 2
- 239000002994 raw material Substances 0.000 claims description 2
- 230000000694 effects Effects 0.000 abstract description 15
- 229940079593 drug Drugs 0.000 abstract description 13
- 238000002360 preparation method Methods 0.000 abstract description 5
- 230000008569 process Effects 0.000 abstract description 2
- 235000011187 glycerol Nutrition 0.000 abstract 1
- 230000029058 respiratory gaseous exchange Effects 0.000 abstract 1
- 239000011505 plaster Substances 0.000 description 19
- 238000004519 manufacturing process Methods 0.000 description 5
- 239000004615 ingredient Substances 0.000 description 3
- 239000003229 sclerosing agent Substances 0.000 description 3
- 239000002390 adhesive tape Substances 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 238000011031 large-scale manufacturing process Methods 0.000 description 2
- WABPQHHGFIMREM-UHFFFAOYSA-N lead(0) Chemical compound [Pb] WABPQHHGFIMREM-UHFFFAOYSA-N 0.000 description 2
- 239000004745 nonwoven fabric Substances 0.000 description 2
- 239000003921 oil Substances 0.000 description 2
- 235000019198 oils Nutrition 0.000 description 2
- 239000002674 ointment Substances 0.000 description 2
- 239000002562 thickening agent Substances 0.000 description 2
- 239000002341 toxic gas Substances 0.000 description 2
- 201000000297 Erysipelas Diseases 0.000 description 1
- 208000003251 Pruritus Diseases 0.000 description 1
- 206010070834 Sensitisation Diseases 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 238000006471 dimerization reaction Methods 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 238000009940 knitting Methods 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 239000012567 medical material Substances 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 229940126701 oral medication Drugs 0.000 description 1
- 230000008520 organization Effects 0.000 description 1
- 230000003204 osmotic effect Effects 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 229940126532 prescription medicine Drugs 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 230000000630 rising effect Effects 0.000 description 1
- 230000008313 sensitization Effects 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 230000002194 synthesizing effect Effects 0.000 description 1
- 230000036413 temperature sense Effects 0.000 description 1
- 238000011200 topical administration Methods 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
Landscapes
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The present invention relates to a Chinese medicine emplastrum matrix which can be added into Chinese medicine extract and its preparation technique. Said matrix is made up by mixing polyacrylic acid, glycerine, triethanolamine, magnesium hydroxide, polyvinylpyrrolidone, azone and water. Said matrix has large medicine-carrying quantity, unique slowly-releasing process, strong transdermal effect, good breathing property and good affinity with various medicines and skin. Said invented matrix is suitable for making Chinese medicine emplastrum, and is an ideal transdermal administration transferring platform.
Description
Technical field
The present invention relates to a kind of substrate and technology of preparing thereof of Chinese medicine plaster patch used material, particularly a kind of Chinese medicine patcher of external.
Background technology
Medicine is the rising industry of 21 century, and Chinese medicine is the industry that China has obvious comparative advantages, has very strong international competitiveness.It is reported the sales volume of whole world transdermal absorption formulation by 1,600,000,000 dollars of 9,100,000,000 dollars of will rise to 2003 in 1993, annually be in first of the various drug forms, market demand and increase very considerable with 17.8% rate of increase.In World Health Organization's prediction 2～3 years from now on, will there be the oral drugs more than 30% need use transdermal administration instead.
The rubber-emplastrum of existing domestic many manufacturer production, ventilative rubber-emplastrum, " Fructus Capsici fourth " type cataplasma and other patch and traditional plaster all exist the appearance dose little, transdermal effect is poor, easily stimulate, easily irritated, can't the slow release efficacy of a drug, can't take off shortcomings such as subsides, viscosity are uncontrollable repeatedly.
Summary of the invention
The purpose of this invention is to provide that a kind of drug loading is big, transdermal effect good, the release ability is strong, toxic and side effects is little, non-stimulated, do not have Chinese medicine patcher substrate irritated, that can take off subsides repeatedly.
Another object of the present invention provides the technology of preparing of this Chinese medicine patcher substrate.
The technical scheme that realizes the object of the invention is: a kind of Chinese medicine patcher substrate, and this substrate is made of by weight mixing following natural and synthetic high molecular polymer:
10～30 parts of 2～10 parts of glycerol of polyacrylic acid
0.2～1.5 part in 1～6 part of magnesium hydroxide of triethanolamine
0.6～5 part of 0.5～3.0 part of azone of polyvinylpyrrolidone
20～80 parts in water
The raw material weight of this substrate is such as following:
20 parts of 5 parts of glycerol of polyacrylic acid
0.6 part in 3 parts of magnesium hydroxide of triethanolamine
1.8 parts of 1.2 parts of azones of polyvinylpyrrolidone
60 parts in water
The technology of preparing of described Chinese medicine patcher substrate is as follows:
The A component: in 15～60 parts of adding agitators of water, turn on agitator adds polyacrylic acid quickly and evenly, and continues to be stirred to into transparent colloid.
B component: triethanolamine and water are mixed for 5～20 parts.
C component: will mix with glycerol behind the magnesium hydroxide porphyrize.
D component:, mix with azone with polyvinylpyrrolidone 50% the aqueous solution that makes into soluble in water.
Mix A component and B component, and stir, add C component and D component more respectively, stirring promptly gets catablasm base material.
Wherein, polyacrylic acid, polyvinylpyrrolidone are thickening agent, and triethanolamine is the PH regulator, and magnesium hydroxide is the gel sclerosing agent, and azone is that substrate helps and oozes promoter.
The present invention adds gel sclerosing agent, wetting agent, substrate later on water-soluble high-molecular material rapid expanding several times in water to help and ooze promoter and active component is made into the external plaster agent again, with traditional plaster, rubber-emplastrum, external use plasters such as ventilative rubber-emplastrum, Fructus Capsici fourth type cataplasma are compared and be it is advantageous that:
1, drug loading is big: medicine can reach 1 with the ratio of substrate: 3-15, thereby the suitable Chinese medical concrete that adds makes Chinese medicine patcher, is ideal percutaneous dosing delivery platform.
2. curative effect height: adopt when preparing traditional plaster medical material is immersed the fried withered method effective component extracting of heating in the vegetable oil, again medicine oil is continued to be heated to several Baidu and Plumbum preparatium and react and form.Therefore big composition and the evaporable composition of some polarity is certain to be lost, and also has many compositions also can be destroyed under hot conditions.And when adopting present technique to prepare,, keep its effective ingredient more, so compare the curative effect that can increase former prescription medicine with traditional plaster owing to scientifically extract ingredient.
3. nontoxic, side effect: in the preparation of traditional plaster because a large amount of toxic gas of generation is at high temperature reacted in oil and Plumbum preparatium, not only severe contamination air, and remain in that erysipelas in the plaster can cause red swelling of the skin, untoward reaction such as itch, fester.Rubber plaster is owing to adopt rubber mass, and it is substrate that " Fructus Capsici fourth " type cataplasma adopts high dimerization material, therefore all skin is had bigger stimulation without exception.And paste with a week so that for more time all to non-stimulated, the no sensitization of skin with the Chinese medicine patcher that present technique is made, and do not pollute clothes, without any side effects.
4. slow release method uniqueness: the Chinese medicine patcher of making of present technique has adopted a kind of new slow release mechanism, can make the medicine slow releasing pharmaceutical in 24 hours to 120 hours even longer time in the substrate.And general patch, cataplasma need to adopt control, release membranes technology again because its hypothallus is thin excessively, and slow release is restricted, and therefore control, slow release effect are also not obvious.
5. transdermal effect is strong: the Chinese medicine patcher of making of present technique adopts natural in the drug matrices layer and the synthesizing water-solubility macromole helps as substrate and oozes promoter, has greatly strengthened transdermal effect, has realized the strong osmotic to skin layer.
6. it is big to contain dose: about 2 to 5 millimeters of the Chinese medicine patcher stromal thickness of making of present technique, and general ventilative rubber plaster and catablasm base material and medicine layer 0.1 millimeter thickness only, compare the substrate that increased more than tens of times and the thickness of medicine layer, the appearance dose is increased exponentially, strengthen the topical administration amount, strengthened medication effect.
7. breathability is better: the Chinese medicine patcher of making of present technique adopt special large-mesh do not have gauze and close knit non-woven fabrics in conjunction with the back as backing layer, greatly reduced the close thickness of knitting non-woven fabrics, so it is, just better than the breathability of traditional plaster and rubber plaster than the good permeability of general cataplasma.
8. the affinity of substrate and various medicines is better: the substrate of the Chinese medicine patcher that present technique is made, for adapting to the interpolation of various medicines, used special neutrality prescription, with assurance and water solublity and water-insoluble, various medicines such as acidity and alkalescence all have affinity and cohesion preferably, medicine is not had any change, is the percutaneous delivery platform of the multiple medicine of ideal interpolation.
9. skin affinity is closer: the Chinese medicine patcher substrate of present technique preparation has strengthened the affinity to human body skin, and ingredient can be subjected to the human body skin temperature sense, and efficiency of drugs can be regulated by skin temperature, takes the back medicine off and just can stop volatilization.And general patch can lose efficacy in the short time after taking off easily in serious volatilization.
10. viscosity is controlled, can take off subsides repeatedly: it is strong excessively that the common drawback of general external use plaster has plenty of viscosity, in a single day takes off during use, and not only easy adhesive tape chaeta also is difficult to keep and recovery viscosity continues to use; Have plenty of when viscosity is used inadequately and come off easily.With the substrate of present technique preparation, can regulate viscosity as required, finished product can be taken off subsides in use repeatedly, can the adhesive tape chaeta, be to paste with exterior-applied formulations easily.
11. medium characteristics is stable, but large-scale production: with the Chinese medicine patcher production technology advanced person of present technique making, its full automatic production equipment has advanced level at home and abroad, its processing and forming ability uniqueness, can be fit to different size, different elasticity, different dilatabilities, the processing and forming of the back lining materials of different pliabilitys can be processed into the different various plaster that paste with the position of human body.Its medium characteristics is stable, through the sealed packet dress, but longer-term storage, convenient transportation is beneficial to the various external use plasters of large-scale production.
12. safety, environmental protection: traditional plaster can produce a large amount of toxic gas in process of production, and not only the grievous injury workman's is healthy, and contaminated environment; Rubber plaster is easily breaking out of fire aborning, causes any property loss, even human casualty accident.And the patch that adopts present technique to make has been avoided these hazardness.
From as can be seen above: the performance of the Chinese medicine patcher of making of present technique is considerably beyond the rubber-emplastrum of Japan and domestic many manufacturer production, ventilative rubber-emplastrum, " Fructus Capsici fourth " type cataplasma and other patch and traditional plaster, it is little obviously to have overcome general patch and plaster appearance dose, transdermal effect is poor, easily stimulate, easily irritated, can't the slow release efficacy of a drug, can't take off shortcomings such as subsides, viscosity are uncontrollable repeatedly.Therefore, if various external use plasters or the traditional plaster sold on the existing market have certain curative effect, adopt the Chinese medicine patcher of the present invention's preparation, curative effect will further manifest and improve.
Specific embodiment
Product of the present invention prepares as stated above, and its detailed component is provided by the following example, but protection scope of the present invention is not limited to this.
Embodiment 1
Component amount (gram/subsides)
Polyacrylic acid 0.45
Glycerol 1.80
Triethanolamine 0.27
Magnesium hydroxide 0.054
Polyvinylpyrrolidone 0.108
Azone 0.162
Water 7.4
Ointment 1.649
Embodiment 2
Component amount (gram/subsides)
Polyacrylic acid 0.51
Glycerol 1.92
Triethanolamine 0.27
Magnesium hydroxide 0.063
Polyvinylpyrrolidone 0.105
Azone 0.162
Water 7.6
Ointment 1.426
The technology of preparing of described Chinese medicine patcher substrate is as follows:
The A component: in 15～60 parts of adding agitators of water, turn on agitator adds polyacrylic acid quickly and evenly, and continues to be stirred to into transparent colloid.
B component: triethanolamine and water are mixed for 5～20 parts.
C component: will mix with glycerol behind the magnesium hydroxide porphyrize.
D component:, mix with azone with polyvinylpyrrolidone 50% the aqueous solution that makes into soluble in water.
Mix A component and B component, and stir, add C component and D component more respectively, stirring promptly gets catablasm base material.
Wherein, polyacrylic acid, polyvinylpyrrolidone are thickening agent, and triethanolamine is the PH regulator, and magnesium hydroxide is the gel sclerosing agent, and azone is that substrate helps and oozes promoter.
Claims (3)
1, a kind of Chinese medicine patcher substrate is characterized in that: this substrate is made of by weight mixing following natural and synthetic high molecular polymer:
10～30 parts of 2～10 parts of glycerol of polyacrylic acid
0.2～1.5 part in 1～6 part of magnesium hydroxide of triethanolamine
0.6～5 part of 0.5～3.0 part of azone of polyvinylpyrrolidone
20～80 parts in water
2, according to the described Chinese medicine patcher substrate of claim, the raw material weight that it is characterized in that this substrate is such as following:
20 parts of 5 parts of glycerol of polyacrylic acid
0.6 part in 3 parts of magnesium hydroxide of triethanolamine
1.8 parts of 1.2 parts of azones of polyvinylpyrrolidone
60 parts in water
3, the technology of preparing of the described Chinese medicine patcher substrate of claim 1 is characterized in that:
The A component: water is added in the agitator, and turn on agitator adds polyacrylic acid quickly and evenly, and continues to be stirred to into transparent colloid.
B component: triethanolamine is mixed with water.
C component: will mix with glycerol behind the magnesium hydroxide porphyrize.
D component:, mix with azone with polyvinylpyrrolidone 50% the aqueous solution that makes into soluble in water.
Mix A component and B component, and stir, add C component and D component more respectively, stirring promptly gets catablasm base material.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200310105804 CN1215831C (en) | 2003-10-08 | 2003-10-08 | Chinese medicine cataplasm matrix and preparing technique thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200310105804 CN1215831C (en) | 2003-10-08 | 2003-10-08 | Chinese medicine cataplasm matrix and preparing technique thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1528270A true CN1528270A (en) | 2004-09-15 |
| CN1215831C CN1215831C (en) | 2005-08-24 |
Family
ID=34304339
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 200310105804 Expired - Lifetime CN1215831C (en) | 2003-10-08 | 2003-10-08 | Chinese medicine cataplasm matrix and preparing technique thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1215831C (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100333720C (en) * | 2005-01-11 | 2007-08-29 | 中国人民解放军第二军医大学 | Compound analgesic agent |
| CN100427128C (en) * | 2005-01-14 | 2008-10-22 | 西北大学 | Babu paste of Chinese medicine for child to reduce fever and its making method |
| CN101254214B (en) * | 2007-02-26 | 2010-10-06 | 江苏七O七天然制药有限公司 | Chinese medicine catablasm base material |
-
2003
- 2003-10-08 CN CN 200310105804 patent/CN1215831C/en not_active Expired - Lifetime
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100333720C (en) * | 2005-01-11 | 2007-08-29 | 中国人民解放军第二军医大学 | Compound analgesic agent |
| CN100427128C (en) * | 2005-01-14 | 2008-10-22 | 西北大学 | Babu paste of Chinese medicine for child to reduce fever and its making method |
| CN101254214B (en) * | 2007-02-26 | 2010-10-06 | 江苏七O七天然制药有限公司 | Chinese medicine catablasm base material |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1215831C (en) | 2005-08-24 |
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| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C56 | Change in the name or address of the patentee | ||
| CP02 | Change in the address of a patent holder |
Address after: High tech Zone Zhang Bayi Road 710065 Shaanxi city of Xi'an province No. 1 Huixin IBC-B block 11 layer Patentee after: XI'AN CHIHO PHARMACEUTICAL Co.,Ltd. Address before: 710075 Shaanxi city of Xi'an province high tech Zone hi tech Road No. 52 building 17 layer Patentee before: XI'AN CHIHO PHARMACEUTICAL Co.,Ltd. |
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| CP01 | Change in the name or title of a patent holder |
Address after: High tech Zone Zhang Bayi Road 710065 Shaanxi city of Xi'an province No. 1 Huixin IBC-B block 11 layer Patentee after: XI' AN CHIHO PHARMACEUTICAL Co.,Ltd. Address before: High tech Zone Zhang Bayi Road 710065 Shaanxi city of Xi'an province No. 1 Huixin IBC-B block 11 layer Patentee before: XI'AN CHIHO PHARMACEUTICAL Co.,Ltd. |
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| CX01 | Expiry of patent term |
Granted publication date: 20050824 |
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| CX01 | Expiry of patent term |