CN1524586A - Preservation method of contact lens - Google Patents
Preservation method of contact lens Download PDFInfo
- Publication number
- CN1524586A CN1524586A CNA03121777XA CN03121777A CN1524586A CN 1524586 A CN1524586 A CN 1524586A CN A03121777X A CNA03121777X A CN A03121777XA CN 03121777 A CN03121777 A CN 03121777A CN 1524586 A CN1524586 A CN 1524586A
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- China
- Prior art keywords
- tablet
- contact lens
- single step
- peroxide
- aforementioned
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- Apparatus For Disinfection Or Sterilisation (AREA)
- Eyeglasses (AREA)
Abstract
The invention provides a tablet comprising, a core including hydrogen peroxide neutralizing agent, tension agent and cushioning agent, and an exterior coating including polyvinyl pyrrolidon and selected coloring agent. The invention also provides the process for preparing the tablet, the use for preserving contact lenses of the tablet, and the one step preserving method of the contact lenses by using the tablet.
Description
Invention field
The present invention relates to the single step store method of contact lens.This method makes the glasses sterilization and is neutralized soon, can directly place on the eyes thereby just needn't clean.
Background of invention
About the problem that contact lens disinfection relates to, be the most effective and safest really by oxidation system sterilization such as hydrogen peroxide.Compare with the time (being generally 6-8 hour) that spends with the disinfectant solution that contains antibacterial (thiomersalate, chlorhexidine etc.), its safety is owing to sterilization faster (3% hydrogenperoxide steam generator is required 15 minutes) is replenished.
In case, contact lens must be immersed in the neutral brine that can decompose peroxide residual in (neutralization) contact lens through the hydrogenperoxide steam generator sterilization.Most of manufacturer uses catalase for this reason in nertralizer solution, so that can in 15 minutes contact lens be placed on the eyes.
These traditional systems that contain disinfectant with hydrogen peroxide liquid and nertralizer solution are called two-step system, must continue to replace disinfectant solution with nertralizer solution for the user.
Recently, Allergan has replaced nertralizer solution with the tablet with identical function, in case promptly glasses are sterilized with peroxide solutions, just can make all hydrogen peroxide inactivations and the tablet that solution is converted into the medium compatible with eyes is mixed in the same solution.This new system also can be described as two-step system because of the user gets involved.
Ciba Geigy company releases a kind of system to market, is about to disinfectant with hydrogen peroxide liquid and pours in the container that has the ring that scribbles platinum black that can make the peroxide inactivation.This system is different with preceding a kind of system, only comprises a step, and the user needn't get involved processing.
Yet platinum loop is the horse back decompose hydroperoxide at the very start, does not guarantee the enough time of disinfectant, therefore is the target of bitter criticism.The single step system for example also is described among the EP-A-0209071 (european patent application 86109361.5), has wherein mentioned the system similar to us in other inventions, in fact can directly not place on the eyes after the processing although there is claim to mention contact lens.In fact, the coating of mentioning for acid medium is dimethylaminomethyl acrylate polymer and neutral methacrylic acid esters, and we find that they stimulate eyes very much, therefore must thoroughly clean glasses.For neutral medium, can mention the coating agent, because of its zest or insoluble, make glasses to clean before use.In both cases, clean the shortcoming that glasses are single step systems subsequently.
Advantage of the present invention
Lay special stress on of the present invention need not to clean subsequently glasses, and this is the remarkable advantage and the improvement of described patent.Like this, the clinical observation of 20 people being carried out test in 2 months shows that system and human eye that the present invention describes are compatible fully.
Body series only relates to a step, and glasses obtain handling because the user need not to get involved.The characteristic of tablet is not carried out the sterilization of peroxide and N-process simultaneously, but neutralizes after sterilization.This is the obvious advantage that surpasses the platinum loop system.
The present invention describes
The present invention relates to sterilize, moistening and in and the method for contact lens.Particularly, it comprises the tablet that mixes hydrogenperoxide steam generator (disinfectant solution) simultaneously and contain active peroxidase (catalyst) in the container that stores contact lens.In 2 hours, finish 3 things: change into contact lens disinfection, moistening with medium and eyes compatible saline solution fully.
By in and the special coating carried out of tablet surface, in case after the glasses sterilization, tablet begins neutralization, wetting action, lubricates contact lens and solution is changed into the isosmoticity saline that pH value is 7.2-7.4, does not need to clean and can directly glasses be placed on the eyes.The disinfectant with hydrogen peroxide agent solution also contains stabilizing agent (for example acetphenetidide) and the buffer agent (for example monosodium phosphate) that prevents peroxide breakdown.
This tablet also contains peroxide nertralizer composition, sodium chloride (its ratio can change into the 10ml disinfectant solution isosmoticity solution) and disodium hydrogen phosphate (its content is enough to the described 10ml peroxide disinfectant solution of pH3.0 is changed into the pH value of 7.2-7.4).
The tablet coating comprises the polymer poly vinylpyrrolidone that dissolves in medium, and its addition was enough to postpone the peroxide neutralization reaction about 15 minutes.Can be by such as the straightforward procedure that polymer is sprayed on the coating container with aspirator; Or adopt method to obtain coating such as easier controls such as fluid bed, Accela cota, Pellegrini.The polymer spraying requires to use the solvent such as sterilized water, ethanol, isopropyl alcohol, dichloromethane, acetone.
In embodiments of the present invention, the coating of tablet also comprises coloring agent.Specifically, the coloring agent of employing is a vitamin B2, is a kind of light-sensitive compound, it is characterized in that making solution to become glassy yellow, and becomes colourless by light degradation.
Described coloring agent in the tablet of the present invention makes the user know when contact lens can use.Specifically, the described coloring agent that exists in the external coating make the detection of its change color easier, quicker.In addition,, coloring agent can not degraded, avoided interference color detection by this composition because this colorant compound is closely not mixed with nuclear core composition.
Entire method can be described below:
The container that contains contact lens is equipped with 10ml disinfectant solution and nertralizer tablet.Preceding 10 minutes, this solution was sterilized glasses, and the tablet coating is slowly dissolved.After 10 or 15 minutes, a small amount of neutralization reaction begins, and reaches the peak after 15-17 minute.After 10-25 minute, finish whole neutralization reactions.After 60 minutes, tablet dissolves fully, and glasses can use.
Tablet composition
Following interval is suitable for peroxide disinfectant solution and nertralizer tablet:
Disinfectant solution
The 2.8-3.5%w/v hydrogen peroxide
0.2-0.3%w/v monosodium phosphate * 2H
2O
The 0.008-0.015%w/v acetphenetidide
Being adjusted to pH with 37% hydrochloric acid is 2.8-3.2.
The nertralizer tablet
(for the 10ml disinfectant solution)
50-70mg NaCl
60-100mg disodium hydrogen phosphate * 2H
2O
The freeze dried catalase of 2080-5400UI
60-110mg polyvinylpyrrolidone (coated polymeric)
0.025-0.25mg vitamin B2
Below be some example of putting into practice compositions of the present invention:
Embodiment 1
Disinfectant solution
The 3.2%w/v hydrogen peroxide
0.20%w/v monosodium phosphate * 2H
2O
The 0.013%w/v acetphenetidide
Being adjusted to pH with 37% hydrochloric acid is 3.0.
The nertralizer tablet
(for the 10ml disinfectant solution)
58mg NaCl
72mg disodium hydrogen phosphate * 2H
2O
The freeze dried catalase of 4000UI
90mg polyvinylpyrrolidone K-30 (coated polymeric)
Embodiment 2
Disinfectant solution
The 3.0%w/v hydrogen peroxide
0.22%w/v monosodium phosphate * 2H
2O
The 0.009%w/v acetphenetidide
Being adjusted to pH with 37% hydrochloric acid is 3.0.
The nertralizer tablet
(for the 10ml disinfectant solution)
68mg NaCl
75mg disodium hydrogen phosphate * 2H
2O
The freeze dried catalase of 2700UI
100mg polyvinylpyrrolidone K-30 (coated polymeric)
0.075mg vitamin B2
When with these two kinds of prescriptions during to contact lens disinfection, the user can directly place them on the eyes and can not feel any discomfort, even than feeling more comfortable with other peroxide disinfecting systems in the past.Different crowd 200 tests have altogether been carried out.
It must be noted that proposing these embodiment describes rather than restriction the present invention, we think and have described feature of the present invention fully.
Claims (16)
1, a kind of tablet is made of kernel and external coating, and described kernel comprises nertralizer, stress drugs (tonicity agent) and the buffer agent of hydrogen peroxide, it is characterized in that described external coating comprises polyvinylpyrrolidone.
2, the tablet of claim 1 is characterized in that described external coating also comprises coloring agent.
3,, it is characterized in that the hydrogen peroxide nertralizer is an active peroxidase, preferred catalase according to the tablet of aforementioned claim.
4, the tablet of claim 3 is characterized in that catalatic concentration is 1080-27000IU, preferred 2700-5400IU.
5,, it is characterized in that stress drugs is a sodium chloride according to the tablet of aforementioned claim.
6,, it is characterized in that buffer agent is a disodium hydrogen phosphate according to the tablet of aforementioned claim.
7,, it is characterized in that coloring agent is a vitamin B2 according to the tablet of aforementioned claim.
8, according to the tablet of aforementioned claim, the concentration that it is characterized in that polyvinylpyrrolidone is 60-110mg, preferred 65-75mg.
9, be used to preserve the purposes of contact lens according to the tablet of claim 1-8.
10, according to the preparation method of the tablet of claim 1-8, comprise by thin film coated applying external coating.
11, the single step store method of contact lens, wherein at first the sterilization then in and glasses, glasses can directly be placed on the eyes and needn't clean, this method comprises contact lens is immersed in the system based on the antiseptic solution of peroxide and tablet that comprises according to claim 1-8.
12,, it is characterized in that comprising hydrogen peroxide, buffer agent, acid and water based on the antiseptic solution of peroxide according to the contact lens single step store method of claim 11.
13,, it is characterized in that having 2-6% (w/v), preferred 2.8-3.2% (w/v), the more preferably concentration of hydrogen peroxide of 3.09% (w/v) based on the antiseptic solution of peroxide according to the contact lens single step store method of claim 11-12.
14,, it is characterized in that buffer agent is a monosodium phosphate according to the contact lens single step store method of claim 11-13.
15,, it is characterized in that acid is 37% hydrochloric acid according to the contact lens single step store method of claim 11-14.
16,, it is characterized in that total soak time of contact lens is at least 45 minutes according to the contact lens single step store method of claim 11-15.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA03121777XA CN1524586A (en) | 2003-02-28 | 2003-02-28 | Preservation method of contact lens |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA03121777XA CN1524586A (en) | 2003-02-28 | 2003-02-28 | Preservation method of contact lens |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1524586A true CN1524586A (en) | 2004-09-01 |
Family
ID=34285789
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNA03121777XA Pending CN1524586A (en) | 2003-02-28 | 2003-02-28 | Preservation method of contact lens |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1524586A (en) |
-
2003
- 2003-02-28 CN CNA03121777XA patent/CN1524586A/en active Pending
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| PB01 | Publication | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |