CN1524420A - Pesticidal composition containing emamectin and pyrethroid compounds - Google Patents
Pesticidal composition containing emamectin and pyrethroid compounds Download PDFInfo
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- CN1524420A CN1524420A CNA031053289A CN03105328A CN1524420A CN 1524420 A CN1524420 A CN 1524420A CN A031053289 A CNA031053289 A CN A031053289A CN 03105328 A CN03105328 A CN 03105328A CN 1524420 A CN1524420 A CN 1524420A
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Abstract
The invention relates to a synergy insecticidal composition which comprises (1) methylamino avermectin and (2) at least one synthetic pyrethroid type insecticidal compound as reactive constituents, wherein the weight ratio of component (1) and component (2) is 1:0.1-100.
Description
Technical field
The present invention relates to a kind of Pesticidal combination, it contain the combination of methylamino avermectin and at least a pyrethroid Pesticidal compound as active component.
Background technology
Crops all need to use a large amount of agricultural chemicals for this reason and carry out the extermination of disease and insect pest to retrieve crop yield loss because damage by disease and insect causes crop yield loss to estimate every year.In recent years, for example the harm on paddy rice, fruit tree, vegetables, flowers and the diversified economy crop is more and more serious crops in insect pest, and because the agricultural chemicals abuse makes the insect resistance more and more serious to the generation of agricultural chemicals, causes pest controling effect to reduce year by year.The pesticide species that therefore, still just need have better pest controling effect.
Methylamino avermectin (emamectin) and salt thereof are a kind of known wide spectrum, the insecticidal/acaricidal agent of low toxicity, can prevent effectively eliminating aphis, various pests such as mite class, diamond-back moth, cabbage caterpillar, Americal rice leaf miner, beet flea beetle, colorado potato beetle, fruit tree leaf roller, oriental fruit moth and scale insect.
The pyrethroid Pesticidal compound is that a class can be widely used in and prevents and treats the various pests for example desinsection and/or the miticide of harmful insect and acarid.
Though as the Pesticidal combination of one of active component, seeing, existing at present many employing Avermectin or pyrethroid Pesticidal compound do not have methylamino avermectin and salt thereof and the two combination of pyrethroid Pesticidal compound Pesticidal combination report as active component.
The present inventor finds that surprisingly the combination of the two has synergistic effect, so finished the present invention.
Summary of the invention
The purpose of this invention is to provide a kind of Pesticidal combination that contains methylamino avermectin and at least a pyrethroid Pesticidal compound as active component, it has excellent synergy control efficiency.
Another object of the present invention provides the preparation method and the application of described Pesticidal combination.
Surprising is, the two the combination of methylamino avermectin and pyrethroid Pesticidal compound has synergistic effect.
The present composition contains the described active component combination of synergy effective dose, and ratio can be arbitrarily between active component, as long as can produce synergistic effect.Generally speaking, the weight ratio of described active component is a methylamino avermectin: pyrethroid Pesticidal compound=1: 0.1-100, preferably the weight ratio of the two is between 1: 1-50, particularly 1: 1-20, more especially 1: in the scope of 1-15.
In the present invention, the pyrethroid Pesticidal compound for example is selected from following: permethrin, cypermethrin, beta-cypermethrin, Cyhalothrin, decis, Biphenthrin, sumicidin, esfenvalerate, fenpropathrin, cycloprothrin, ether chrysanthemum ester, flucythrinate, taufluvalinate, tefluthrin, tralomethrin and cyfloxylate.Preferably, for example be selected from following: cypermethrin, beta-cypermethrin, fenpropathrin, cycloprothrin, Cyhalothrin, decis, sumicidin and esfenvalerate.More preferably, for example be selected from cypermethrin, beta-cypermethrin, decis, sumicidin, esfenvalerate and Cyhalothrin.Described compound is known, the preparation of these compounds and use can referring to, for example, external pesticide species handbook, new edition bound volume, the Ministry of Chemical Industry's agricultural chemicals central information facility, 1998.
In this article, methylamino avermectin (emamectin) is meant methylamino avermectin and its esters for example hydrochloride and benzoate.Described salt can be anhydrous, or its possible moisture crystal formation.Emamection benaoate preferably.The preparation of methylamino avermectin and salt thereof can referring to, for example, US4,874,749, US5,288,710, US5,362,863, US5,399,717, CN1129453, CN1283960, J.Org.Chem.59 (29), 7870-5 (1994).
The present invention's combination can convert conventional formulation such as missible oil, wetting powder, granula, soluble powder, water dispersible granules, suspending agent, aqueous emulsion, microemulsion, emulsion, pulvis, dust base, paste and water surface leafing agent to.
Administration form depends on specific use; In all cases, must guarantee that their dispersion is trickle as much as possible and even.
These preparations can prepare in a known manner, for example by with reactive compound solvent and/or carrier, if desired, adopt emulsifier and dispersant to fill, if use water as thinner, also can make cosolvent with other organic solvent.
The cosolvent that is suitable for this purpose mainly is :-solvent such as aromatic compounds (for example dimethylbenzene), chloro aromatic compounds (for example chlorobenzene), paraffin (for example petroleum cuts), alcohols (for example methyl alcohol, butanols), ketone (for example cyclohexanone), amine (for example monoethanolamine, dimethyl formamide) and water;-carrier is as the natural mineral matter (for example kaolin, alumina, talcum, chalk) that grinds and the synthetic mineral matter (for example silicic acid of high dispersive, silicate) of grinding;-emulsifier such as nonionic and anion emulsifier (for example polyoxyethylene aliphatic alcohol ether, alkylsulfonate and arylsulphonate) and-dispersant such as lignin sulfite waste liquor or methylcellulose.
The surface reactive material that is fit to is an aromatic sulfonic acid (lignosulphonic acid for example, phenolsulfonic acid, naphthalene sulfonic acids and dibutyl naphthalene sulfonic acids) and the alkali metal of fatty acid, alkaline earth metal and ammonium salt, alkylsulfonate and alkylaryl sulfonates, alkyl sulfate, lauryl ether sulfuric acid and aliphatic alcohol sulfate, and Sulfated 16-, 17-and the salt of octadecanol and fatty alcohol ether, sulfonated naphthalene and its derivative and formaldehyde condensation product, the condensation product of naphthalene or naphthalene sulfonic acids and phenol and formaldehyde, polyoxyethylene octylphenol ether, the iso-octyl of ethyoxyl alkanisation-, octyl group-or nonyl phenol, alkylphenol or tributyl phenyl polyglycol ether, alkyl aryl polyether alcohol, different three decyl alcohol, the fatty alcohol ethylene oxide condensate, ethoxylated castor oil, polyoxyethylene-or the polyoxypropylene alkyl ether, laruyl alcohol polyglycol ether acetic acid esters, sorbitan ester, lignin sulfite waste liquor or methylcellulose.
Moisture administration form can be by adding water, for example by missible oil, dispersion liquid, paste, wetting powder, effervescent agent or water dispersible granule preparation.When preparation emulsion, paste, oily dispersion liquid or liquid water surface leafing agent,, material is homogenized in water or be dissolved in oil or the solvent by adding wetting agent, adhesive, dispersant or emulsifier.And, also can prepare by active substance, wetting agent, adhesive, dispersant or emulsifier and possible solvent or the oily concentrate of forming, this concentrate is suitable for dilute with water.
Pulvis, spreading fertilizer over the fields pulvis, effervescent agent, solid-state water surface leafing agent composition can be by mixing active substance or grinding and produce with solid carrier.
Granule (for example, coating, dipping or homogeneous particle agent) can prepare by reactive compound is adhered on the solid carrier.
Solid carrier is that ore soil is as silica gel, silicic acid, silicate, talcum, kaolin, lime stone, lime, chalk, bole, loess, potter's clay, dolomite, diatomite, calcium sulphate and magnesium sulfate, magnesia, the synthetic material, the chemical fertilizer that grind are as ammonium sulfate, ammonium phosphate, ammonium nitrate, urea and plant product such as flour, bark powder, wood powder and shuck powder, cellulose powder and other solid carrier.Activity compound concentration in direct useful formulations can change in wide relatively scope.
Usually, composition contains 0.01 to 90% active component by weight, and usually according to the difference of preparation type, preferably contains 0.5 to 50% active component by weight.
Control is during animal pest, and preparation contains by weight 0.0001 to 10%, and preferred 0.01 to 1% reactive compound by weight is preferred.
Present composition application dosage, the difference according to factors such as different crops, time of application, weather conditions is generally 1-1000g a.i./ha, is preferably 5-300g a.i./ha.The general foliage applying that adopts, for example foliar spray is handled.Also can do other and handle as seed dressing, filling root etc., in this case, can adjust application dosage as required.For example when soil treatment control soil insect, application dosage is in the scope of 10-3000ga.i./ha.
Pesticidal combination of the present invention can be widely used in the insect on control vegetables (as tomato, capsicum, cucumber, Chinese cabbage, custard squash), potato, beet, paddy rice, cotton, tobacco and the fruit tree crops such as (as apple, cherry, citrus), is used to prevent and treat for example various pests such as aphid, leafhopper, plant hopper, thrips, aleyrodid, wireworm, beet flea beetle, colorado potato beetle, fruit tree leaf roller, oriental fruit moth, scale insect, diamond-back moth, cabbage caterpillar, Americal rice leaf miner, rice borer, tetranychid, full melon mite, goitre mite, tarsonemid.
Other purpose of the present invention and advantage are described further by following examples.
Embodiment
The present invention describes with the following example, but does not limit the present invention.
Example of formulations 1:2.5% missible oil
Raw material consumption (weight portion)
Emamection benaoate 0.2
Cypermethrin 2.3
Emulsifier 0,201 8.0
Penetrating agent JFC 2.0
Dimethylbenzene 87.5
Take by weighing active component and be dissolved in the solvent xylene, and then add emulsifier, stir, promptly make described 2.5% missible oil.
Example of formulations 2:1% missible oil
Raw material consumption (weight portion)
Emamection benaoate 0.2
Cyhalothrin 0.8
Emulsifier 2,201 8.0
Dimethylbenzene 91.0
Take by weighing active component and be dissolved in the solvent xylene, and then add emulsifier, stir, promptly make described 1.0% missible oil.
Example of formulations 3:8% missible oil
Raw material consumption (weight portion)
Methylamino avermectin 0.5
Cyfloxylate 7.5
Emulsifier 2,201 12.0
Dimethylbenzene 80.0
Take by weighing active component and be dissolved in the solvent xylene, and then add emulsifier, stir, promptly make described 8% missible oil.
Example of formulations 4:1.0% missible oil
Raw material consumption (weight portion)
Emamection benaoate 0.1
Decis 0.9
Emulsifier 0,202 12.0
Dimethylbenzene 87.0
Take by weighing active component and be dissolved in the solvent xylene, and then add emulsifier, stir, promptly make described 1.0% missible oil.
Example of formulations 5:10% missible oil
Raw material consumption (weight portion)
Emamection benaoate 0.5
Esfenvalerate 9.5
Emulsifier 0,204 15.0
Dimethylbenzene 75.0
Take by weighing active component and be dissolved in the solvent xylene, and then add emulsifier, stir, promptly make described 10% missible oil.
Example of formulations 6:10% wetting powder
Raw material consumption (weight portion)
Emamection benaoate 0.5
Ether chrysanthemum ester 9.5
JFC?????????????????????????????????????????2.0
Sodium lignosulfonate 4.0
Precipitated calcium carbonate 84
With precipitated calcium carbonate precomminution, then it is fully mixed with above-mentioned other composition earlier, adopt comminution by gas stream processing again, make described 10% wetting powder.
Example of formulations 7:20% wetting powder
Raw material consumption (weight portion)
Methylamino avermectin hydrochloride 1.0
Fenpropathrin 19.0
JFC?????????????????????????????????????????2.0
Sodium lignosulfonate 5.0
Precipitated calcium carbonate 73
With precipitated calcium carbonate precomminution, then it is fully mixed with above-mentioned other composition earlier, adopt comminution by gas stream processing again, make described 20% wetting powder.
Example of formulations 8:6% wetting powder
Raw material consumption (weight portion)
Emamection benaoate 1.0
Taufluvalinate 5.0
Neopelex 2.0
Sodium lignosulfonate 3.0
Diatomite 40.0
Precipitated calcium carbonate 49.0
With diatomite and precipitated calcium carbonate precomminution, then it is fully mixed with above-mentioned other composition earlier, adopt comminution by gas stream processing again, make described 6% wetting powder.
Example of formulations 9:12% wetting powder
Raw material consumption (weight portion)
Emamection benaoate 2.0
Cyfloxylate 10.0
Neopelex 2.5
Sodium lignosulfonate 2.5
White carbon 10.0
Precipitated calcium carbonate 73.0
With precipitated calcium carbonate precomminution, then it is fully mixed with above-mentioned other composition earlier, adopt comminution by gas stream processing again, make described 12% wetting powder.
Example of formulations 10:5% aqueous emulsion
Raw material consumption (weight portion)
Emamection benaoate 0.7
Beta-cypermethrin 4.3
Farming breast No. 300 10.0
Dimethylbenzene 20.0
Ethanol 2.0
Glycerine 5.0
Water 58.0
Earlier active component is dissolved in the solvent xylene, and adds cosolvent ethanol, in the heated and stirred process, add emulsifier and add glycerine and deionized water then, stir, promptly make described 5% aqueous emulsion.
Example of formulations 11:6% microemulsion
Raw material consumption (weight portion)
Emamection benaoate 0.6
Cypermethrin 5.4
Nongru-700 numbers 15.0
Dimethylbenzene 20.0
Ethanol 2.0
Glycerine 5.0
Water 52.0
Earlier active component is dissolved in the solvent xylene, and adds cosolvent ethanol, in the heated and stirred process, add emulsifier and add glycerine and deionized water then, stir, promptly make described 6% microemulsion.
Example of formulations 12:10% microemulsion
Raw material consumption (weight portion)
Methylamino avermectin hydrochloride 0.8
Sumicidin 9.2
Nongru-700 numbers 20.0
Dimethylbenzene 20.0
Isopropyl alcohol 2.0
Polyethylene glycol 10.0
Water 38.0
Earlier active component is dissolved in the solvent xylene, and adds the cosolvent isopropyl alcohol, in the heated and stirred process, add emulsifier and add polyethylene glycol and deionized water then, stir, promptly make described 10% microemulsion.
Example of formulations 13:5% effervescent agent
Raw material consumption (weight portion)
Methylamino avermectin hydrochloride 0.6
Decis 4.4
Sodium bicarbonate 30.0
Citric acid 26.0
Precipitated calcium carbonate 33.0
Talcum powder 6.0
Each drying materials is levigate, mix then, make it to decompose evenly, promptly make described 5% effervescent agent.
Example of formulations 14:10% effervescent agent
Raw material consumption (weight portion)
Methylamino avermectin hydrochloride 1.0
Cypermethrin 9.0
Sodium bicarbonate 22.0
Oxalic acid 26.0
Precipitated calcium carbonate 38.0
Talcum powder 4.0
Each drying materials is levigate, mix then, make it to decompose evenly, promptly make described 10% effervescent agent.
Biological Examples 1 diamond-back moth control synergy test (1) methylamino avermectin and Cyhalothrin combination are to the synergy test of diamond-back moth
Earlier with Cyhalothrin, emamection benaoate dissolves with proper amount of acetone, water claims to release respectively again, be made into the mother liquor of 1000ppm, then with Cyhalothrin, the proportioning combination that provides in the emamection benaoate following table 1 is made into the soup that activity component concentration is 1000ppm, and water claims to release to 6 series concentration successively respectively, and cabbage leaves immerses soup to be measured, treat that blade soaks the back taking-up fully and dries, placing diameter is the 9cm culture dish, preserve moisture with wet cotton, each culture dish is pressed 20 of 2-3 diamondback moth larvaes in age, and every concentration repeats 3 times, establishes the clear water contrast, check after 72 hours and respectively repeat extremely, borer population alive, obtain corrected mortality, set up the associated straight lines regression equation of drug concentration logarithm value and dead probit value, try to achieve the lethal concentration of 50 (LC by statistical method
50), with each combination of mensuration and the LC of two kinds of single agent
50Value is that standard meter is calculated actual toxicity index with the emamection benaoate, calculates the co-toxicity coefficient of each combination at last by following formula.The result is as shown in table 1.
Co-toxicity coefficient=actual toxicity index/theoretical toxicity index * 100.
(combination of λ-cyhalothrin) is to the synergistic effect of diamond-back moth for table 1 methylamino avermectin and Cyhalothrin
| Chemicals treatment | Virulence regression equation | ??LC 50??(ppm) | Correlation coefficient | Actual toxicity index | Theoretical toxicity index | Co-toxicity coefficient |
| Emamection benaoate (A) | Y＝5.663+0.845X | ????2.29 | ????0.945 | ??100 | ???- | ?????- |
| Cyhalothrin (B) | Y＝1.442+1.407X | ????3.29 | ????0.979 | ??0.149 | ???- | ?????- |
| ????A+B(2∶3) | Y＝5.380+0.515X | ????0.98 | ????0.931 | ??9.934 | ??40.029 | ????224.7 |
| ????A+B(3∶7) | Y＝5.459+0.639X | ????1.32 | ????0.999 | ??85.849 | ??30.034 | ????285.8 |
| ????A+B(1∶4) | Y＝5.336+0.580X | ????1.91 | ????0.960 | ??69.513 | ??20.039 | ????346.3 |
By last table 1 as seen, described the present invention's combination has significant synergistic insecticidal action.
(2) combination of methylamino avermectin and cypermethrin is to the synergy test of diamond-back moth
Earlier with cypermethrin, emamection benaoate dissolves with proper amount of acetone, water claims to release respectively again, be made into the mother liquor of 1000ppm, then with cypermethrin, the proportioning combination that provides in the emamection benaoate following table 2 is made into the soup that activity component concentration is 1000ppm, and water claims to release to 6 series concentration successively respectively, and cabbage leaves immerses soup to be measured, treat that blade soaks the back taking-up fully and dries, placing diameter is the 9cm culture dish, preserve moisture with wet cotton, each culture dish is pressed 20 of 2-3 diamondback moth larvaes in age, and every concentration repeats 3 times, establishes the clear water contrast, check after 72 hours and respectively repeat extremely, borer population alive, obtain corrected mortality, set up the associated straight lines regression equation of drug concentration logarithm value and dead probit value, try to achieve the lethal concentration of 50 (LC by statistical method
50), with each combination of mensuration and the LC of two kinds of single agent
50Value is that standard meter is calculated actual toxicity index with the emamection benaoate, calculates the co-toxicity coefficient of each combination at last by following formula.The result is as shown in table 2.
Co-toxicity coefficient=actual toxicity index/theoretical toxicity index * 100.
Table 2 methylamino avermectin and cypermethrin combination are to the synergistic effect of diamond-back moth
| Chemicals treatment | Virulence regression equation | Correlation coefficient | ??LC 50??(ppm) | Actual toxicity index | Theoretical toxicity index | Co-toxicity coefficient |
| Emamection benaoate (A) | ??Y＝4.4729+1.2529X | ??0.9834 | ??2.99 | ??100 | ||
| Cypermethrin (B) | ??Y＝4.2002+1.2529X | ??0.9758 | ??4.35 | ??68.74 | ||
| ??A+B(1∶5) | ??Y＝6.3925+0.9345X | ??0.9755 | ??1.35 | ??221.48 | ??73.95 | ????299.5 |
| ??A+B(1∶9) | ??Y＝5.5468+0.9320X | ??0.9837 | ??0.56 | ??533.93 | ??71.87 | ????742.91 |
| ??A+B(1∶13) | ??Y＝5.1248+0.8611X | ??0.9872 | ??0.87 | ??343.68 | ??70.97 | ????484.26 |
By last table 2 as seen, described the present invention's combination has significant synergistic insecticidal action.
(3) combination of methylamino avermectin and decis is to the synergy test of diamond-back moth
Earlier with decis, emamection benaoate dissolves with proper amount of acetone, water claims to release respectively again, be made into the mother liquor of 1000ppm, then with decis, the proportioning combination that provides in the emamection benaoate following table 3 is made into the soup that activity component concentration is 1000ppm, and water claims to release to 6 series concentration successively respectively, and cabbage leaves immerses soup to be measured, treat that blade soaks the back taking-up fully and dries, placing diameter is the 9cm culture dish, preserve moisture with wet cotton, each culture dish is pressed 20 of 2-3 diamondback moth larvaes in age, and every concentration repeats 3 times, establishes the clear water contrast, check after 72 hours and respectively repeat extremely, borer population alive, obtain corrected mortality, set up the associated straight lines regression equation of drug concentration logarithm value and dead probit value, try to achieve the lethal concentration of 50 (LC by statistical method
50), with each combination of mensuration and the LC of two kinds of single agent
50Value is that standard meter is calculated actual toxicity index with the emamection benaoate, calculates the co-toxicity coefficient of each combination at last by following formula.The result is as shown in table 3.
Co-toxicity coefficient=actual toxicity index/theoretical toxicity index * 100.
Table 3 methylamino avermectin and decis combination are to the synergistic effect of diamond-back moth
| Chemicals treatment | Virulence regression equation | Correlation coefficient | ??LC 50??(ppm) | Actual toxicity index | Theoretical toxicity index | Co-toxicity coefficient |
| Emamection benaoate (A) | Y＝4.8162+0.5379X | ??0.9887 | ??2.20 | ???100 | ||
| Decis (B) | Y＝4.5911+0.5064X | ??0.9967 | ??6.42 | ???34.27 | ||
| ??A+B(1∶3) | Y＝4.8910+0.5465X | ??0.9868 | ??1.58 | ???139.24 | ???50.7 | ??274.64 |
| ??A+B(1∶7) | Y＝5.1796+1.5135X | ??0.9756 | ??0.76 | ???289.47 | ??42.49 | ??681.27 |
| ?A+B(1∶11) | Y＝4.7464+0.9701X | ??0.9796 | ??1.83 | ???120.22 | ??39.75 | ??302.44 |
By last table 3 as seen, described the present invention's combination has significant synergistic insecticidal action.
(4) combination of methylamino avermectin and sumicidin is to the synergy test of diamond-back moth
Earlier with sumicidin, emamection benaoate dissolves with proper amount of acetone, water claims to release respectively again, be made into the mother liquor of 1000ppm, then with sumicidin, the proportioning combination that provides in the emamection benaoate following table 4 is made into the soup that activity component concentration is 1000ppm, and water claims to release to 6 series concentration successively respectively, and cabbage leaves immerses soup to be measured, treat that blade soaks the back taking-up fully and dries, placing diameter is the 9cm culture dish, preserve moisture with wet cotton, each culture dish is pressed 20 of 2-3 diamondback moth larvaes in age, and every concentration repeats 3 times, establishes the clear water contrast, check after 72 hours and respectively repeat extremely, borer population alive, obtain corrected mortality, set up the associated straight lines regression equation of drug concentration logarithm value and dead probit value, try to achieve the lethal concentration of 50 (LC by statistical method
50), with each combination of mensuration and the LC of two kinds of single agent
50Value is that standard meter is calculated actual toxicity index with the emamection benaoate, calculates the co-toxicity coefficient of each combination at last by following formula.The result is as shown in table 4.
Co-toxicity coefficient=actual toxicity index/theoretical toxicity index * 100.
Table 4 methylamino avermectin and sumicidin combination are to the synergistic effect of diamond-back moth
| Chemicals treatment | Virulence regression equation | Correlation coefficient | ??LC 50??(ppm) | Actual toxicity index | Theoretical toxicity index | Co-toxicity coefficient |
| Emamection benaoate (A) | ??Y＝4.9361+1.2982X | ??0.9917 | ??3.42 | ??100 | ||
| Sumicidin (B) | ??Y＝4.2963+0.8318X | ??0.9823 | ??7.01 | ??48.79 | ||
| ?A+B(1∶7) | ??Y＝4.9650+1.3201X | ??0.9846 | ??1.06 | ??322.64 | ??55.19 | ??584.6 |
| ?A+B(1∶11) | ??Y＝5.1030+1.1593X | ??0.9698 | ??0.82 | ??417.07 | ??53.06 | ??786.03 |
| ?A+B(1∶15) | ??Y＝5.0978+1.7624X | ??0.9844 | ??0.88 | ??388.64 | ??51.99 | ??747.53 |
By last table 4 as seen, described the present invention's combination has significant synergistic insecticidal action.
Biological Examples 2 Americal rice leaf miner adults control synergy test
Adopt the residual method of Mason (1987a) (medicine embrane method).Various agricultural chemicals acetone solutions to be measured are inhaled 5ml, are in the bilateral glass tube of 30mm * 250mm in diameter * length, and the rotation glass-tube is uniformly distributed on the glass tube soup, till the soup volatilization.Insert then with the good 3-4 adult in age of etherization, 30 of every pipes repeat 3 times.The glass tube two ends with the rubber stopper of mesh, place glass tube in the special ventilated box of lucite beyond the Great Wall.Exhaust fan is loaded onto on one side of case, Yi Bian fan transfer to adult can be from not being drawn onto gentle breeze speed (the ventilation 0.079m of another side
2/ s).Test is carried out in above-mentioned insectary, adds up death toll (can not normally creep and be considered as death) after 24 hours.When control group (CK) lethality surpassed 20%, this group experimental data was got rid of outside analyzing, and reforms.Carry out data with the FX-3600p calculator and return, obtain regression equation, LC
50And LC
5095% confidence limit.Combination preparation calculates co-toxicity coefficient with the abundant method of Sun Yun.The results are shown in Table 5.
The LC of single agent toxicity index (TI)=standard insecticide
50/ for the LC that surveys insecticide
50* 100
The LC of the single usefulness of the actual measurement toxicity index (ATI) of combination (A+B)=A agent
50/ (A+B) LC
50* 100
The theoretical toxicity index (ATI) * 100 of actual measurement toxicity index (the ATI)/combination of theoretical toxicity index (the TTI)=combination of combination
CTC＞100 synergistic effects
The CTC=100 summation action
CTC＜100 antagonisms
Table 5 methylamino avermectin and beta-cypermethrin are to the synergy test (medicine embrane method) of Americal rice leaf miner adult
| Chemicals treatment | Virulence regression equation | ???LC 50(95% confidence limit) ppm | Co-toxicity coefficient |
| Emamection benaoate (A) | Y＝5.088+1.249X | ????0.85(0.76-0.95) | ?????- |
| Beta-cypermethrin (B) | Y＝4.168+1.093X | ????5.77(5.07-6.56) | ?????- |
| ?A+B(1∶5) | Y＝4.716+0.927X | ????2.02(1.74-2.36) | ????145.4 |
| ?A+B(1∶6.5) | Y＝4.963+0.947X | ????1.09(0.94-1.27) | ????298.8 |
| ?A+B(1∶8) | Y＝4.798+0.671X | ????2.00(1.63-2.46) | ????175.6 |
By table 5 as seen, described the present invention's combination has significant synergies.
Bioexperiment example 3 Americal rice leaf miner larvas control synergy test
The Kidney bean seedling flowerpot that growth is consistent is put into illumination box (26 ± 1 ℃ of temperature, 70 ± 1 ℃ of humidity, photoperiod L: D=14: 10), about 500 liriomyza bryoniae adults are put into wherein, after 1 hour, catch up with the adult on the most seedling, flowerpot moved on in the illumination box of another the same terms, when larvae development during to 3 ages (5-6) day begin to test.
The blade method is soaked in employing.The Kidney bean seedling of every dish having been counted the larva number takes out soak 5 seconds in the aqueous solution of test medication after, treat that soup is done after, put the plastics freshness protection package of two open ends, bandage at the seedling base portion, be used to collect pupa.3 concentration are established in test, and each concentration 1 basin (3 strain) repeats 4 times.Place illumination box to raise these processing, wait the control group larva all to pupate and the back 2-3 days statistics death toll (lethality=larva sum-sprout wings into borer population) of sprouting wings, calculate lethality, regression equation, LC
50And LC
5095% confidence limit.The computational methods of co-toxicity coefficient are with biological Examples 2.The results are shown in Table 6.
Table 6 methylamino avermectin and beta-cypermethrin are to the synergy test (leaf dipping method 5 strains) of Americal rice leaf miner larva
| Chemicals treatment | Virulence regression equation | ???LC 50(95% confidence limit) ppm | Co-toxicity coefficient |
| Emamection benaoate (A) | Y＝5.372+1.321X | ????0.53(0.48-0.58) | ??????- |
| Beta-cypermethrin (B) | Y＝4.423+0.998X | ????3.78(3.36-4.26) | ??????- |
| ?A+B(1∶5) | Y＝4.897+0.850X | ????1.32(1.16-1.51) | ????141.6 |
| ?A+B(1∶7) | Y＝5.096+1.053X | ????0.81(0.72-0.90) | ????264.1 |
| ?A+B(1∶8) | Y＝4.960+0.867X | ????1.11(0.97-1.26) | ????202.5 |
By table 6 as seen, described the present invention's combination has significant synergies.
Biological Examples 4 diamond-back moth daejeon prevention tests
Test adopts 1.0% cream preparation of preparation enforcement 4 as preparation of the present invention.1000,2000,3000 times of the present invention's 1.0% cream preparations are established in test, with 2000 times of 1% emamection benaoate missible oil and 2.5% deltamethrin milk oil serves as the contrast medicament for 1000 times, is contrast with the spray clear water, 15 square metres of every sub-district areas, repeat randomized arrangement 4 times.For studying thing is cauliflower, and duration of test is handled the rosette stage.
Adopt the spraying of workers and peasants-16 type knapsack hand sprayer, spray sheet aperture is 1.3 millimeters, and operating pressure is 0.3-0.4kPa.50 kilograms of every mu of spraying liquids.Examination in 1,3 and 7 day borer population amount alive before medicine, insect population gradient and control efficiency are calculated in fixed point investigation 4 strains of every sub-district.Test data is respectively handled the significance of difference of control efficiency through variance analysis with the inspection of LSR method.Computing formula:
Borer population alive * 100% before insect population gradient (%)=(borer population of living behind the preceding borer population-spray medicine of living of spray medicine)/spray medicine
Control efficiency (%)=(pt ± pck)/(100 ± pck) * 100%
Annotate: pt is spray medicine post processing zone insect population gradient; Pck is a check plot insect population gradient behind the spray medicine.
When insect population increases behind the check plot spray medicine with "+", when insect population reduces behind the check plot spray medicine with "-".
Result such as following table 7.
The control in field effect of table 7 diamond-back moth
| Handle | Radix (head) before the medicine | Behind the medicine 1 day | Behind the medicine 3 days | Behind the medicine 7 days | |||
| Borer population (head) alive | Proofread and correct preventive effect (%) | Borer population (head) alive | Proofread and correct preventive effect (%) | Borer population (head) alive | Proofread and correct preventive effect (%) | ||
| 1000 times of 1.0% missible oil of the present invention | ??33.25 | ????21.0 | ??43.79 | ????4.75 | ??90.55aA | ??4.75 | ??93.98aA |
| 2000 times of 1.0% missible oil of the present invention | ??45.75 | ????31.75 | ??38.24 | ????11.25 | ??83.74aA | ??8.5 | ??92.16aA |
| 3000 times of 1.0% missible oil of the present invention | ??38.25 | ????30.0 | ??30.20 | ????12 | ??79.25aA | ??11.25 | ??87.59aA |
| 1000 times of 2.5% deltamethrin milk oils | ??46 | ????26.5 | ??48.73 | ????24.25 | ??63.13aA | ??61 | ??40.07bB |
| 2000 times of 1.0% emamection benaoates | ??27.75 | ????18.75 | ??32.43 | ????6 | ??85.70aA | ??7.75 | ??86.61aA |
| Clear water CK | ??72.75 | ????81.75 | ???- | ????110 | ????- | ??172.5A | ????- |
As seen from the above table, described the present invention's combination has significant synergistic insecticidal action.
Biological Examples 5 Americal rice leaf miner daejeon prevention tests
Test adopts 2.5% cream preparation of preparation enforcement 1 as preparation of the present invention.1000,2000,3000 times of the present invention's 2.5% cream preparations are established in test, with 1000 times of 1% emamection benaoate missible oil and 10% permethrin milk oil serves as the contrast medicament for 2000 times, is contrast with the spray clear water, 21.6 square metres of every sub-district areas, repeat randomized arrangement 4 times.For studying thing is wild cabbage.
Telltale mark is looked into insect pest situation.Select to have 25 in worm tunnel before the medicine of sub-district at random, dip in the lacquer of learning from else's experience with writing brush and be marked with worm end (getting the food hole), mark crosspiece gallery, it is neat to require to be labeled instar larvae, with the road moderate length, is comma or short snake shape; Bore worker manual sprayer spraying with workers and peasants' 16 types the same day behind the mark, being meticulous and attending to minutes details in everything as far as possible, evenly is sprayed onto the mark larva.Add up the larva number of living respectively on the 1st, 4 and 7 day behind the medicine, calculate control efficiency.Determine anyway with larva in the road.Standard is: larva body colour browning is deepened, and stops extension person with the road and is considered as dead worm; It is yellow that the larva body colour is, and prolongs secondary certain distance with the road, and sky does not have worm with the road and also is considered as the worm that lives.
Preventing and treating method, drug effect and computing formula is:
Proofread and correct control (%)=[1-(mark larva number alive in clear area behind medicine post processing zone mark larva number/medicine alive)] * 100.
The DMRT method is carried out significance test.The results are shown in following table 8.
The control in field effect of table 8 Americal rice leaf miner
| Handle | Radix (head) before the medicine | Behind the medicine 1 day | Behind the medicine 4 days | Behind the medicine 7 days | |||
| Borer population (head) alive | Proofread and correct preventive effect (%) | Borer population (head) alive | Proofread and correct preventive effect (%) | Borer population (head) alive | Proofread and correct preventive effect (%) | ||
| 1000 times of 2.5% missible oil of the present invention | ????100 | ????28 | ????71.43 | ????18 | ????81.05 | ????15 | ????82.76 |
| 2000 times of 2.5% missible oil of the present invention | ????100 | ????33 | ????66.33 | ????23 | ????75.79 | ????18 | ????77.01 |
| 3000 times of 2.5% missible oil of the present invention | ????100 | ????42 | ????57.14 | ????34 | ????64.21 | ????25 | ????71.26 |
| 2000 times of 10% permethrin milk oils | ????100 | ????29 | ????70.41 | ????22 | ????76.84 | ????21 | ????75.86 |
| 1000 times of 1.0% emamection benaoates | ????100 | ????31 | ????63.77 | ????28 | ????70.53 | ????26 | ????70.11 |
| Clear water CK | ????100 | ????98 | ???- | ????95 | ?????- | ????87 | ?????- |
As seen from the above table, described the present invention's combination has significant synergistic insecticidal action.
Though above the present invention is described in detail with a general description of the specific embodiments, on basis of the present invention, can make some modifications or improvements it, this will be apparent to those skilled in the art.Therefore, not departing from the these modifications or improvements basically of spirit of the present invention, all belong to the scope of protection of present invention.
Claims (8)
1. a Pesticidal combination is characterized in that, it comprises a) methylamino avermectin and b) at least a pyrethroid Pesticidal compound is as active component, component a) and components b) weight ratio be 1: 0.1-100.
2. according to the Pesticidal combination of claim 1, wherein, component a) and components b) weight ratio be 1: 1-20.
3. according to the Pesticidal combination of claim 2, wherein, methylamino avermectin is selected from methylamino avermectin, methylamino avermectin hydrochloride and emamection benaoate.
4. according to arbitrary Pesticidal combination of claim 1-3, wherein, the pyrethroid Pesticidal compound is selected from following: permethrin, cypermethrin, beta-cypermethrin, Cyhalothrin, decis, Biphenthrin, sumicidin, esfenvalerate, fenpropathrin, cycloprothrin, ether chrysanthemum ester, taufluvalinate, tefluthrin, tralomethrin and cyfloxylate.
5. according to the Pesticidal combination of claim 4, wherein, the pyrethroid Pesticidal compound is selected from: cypermethrin, beta-cypermethrin, Cyhalothrin, decis, sumicidin and esfenvalerate.
6. according to the Pesticidal combination of claim 5, wherein, methylamino avermectin is an emamection benaoate, and pyrethroid insecticides is selected from cypermethrin, beta-cypermethrin, sumicidin, esfenvalerate, decis and Cyhalothrin.
7. according to arbitrary Pesticidal combination of claim 1-6, wherein, described Pesticidal combination is missible oil, wetting powder, granula, soluble powder, water dispersible granules, suspending agent, aqueous emulsion, microemulsion, emulsion, pulvis, dust base, effervescent agent, paste and water surface leafing agent formulation.
8. according to the Pesticidal combination of claim 7, wherein, described Pesticidal combination is missible oil, wetting powder, granula, soluble powder, water dispersible granules, suspending agent, aqueous emulsion, microemulsion and water surface leafing agent formulation.
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| CN102017989A (en) * | 2010-12-15 | 2011-04-20 | 广西安泰化工有限责任公司 | Efficient cyhalothrin and emamectin benzoate composition and preparations thereof |
| CN103004858A (en) * | 2012-11-28 | 2013-04-03 | 李建中 | Insecticidal composition containing methylamino abamectin and pyrethroid compound |
| CN103371154A (en) * | 2012-04-12 | 2013-10-30 | 陕西韦尔奇作物保护有限公司 | Pesticide combination containing chromafenozid and biological source |
| CN103385254A (en) * | 2012-05-07 | 2013-11-13 | 陕西韦尔奇作物保护有限公司 | Insecticidal composition comprising tefluthrin and biological source |
| CN103651522A (en) * | 2013-10-31 | 2014-03-26 | 湖南农业大学 | Deltamethrin or composition thereof and application in preventing plant nematodiasis |
| CN103931649A (en) * | 2014-05-05 | 2014-07-23 | 北京市农林科学院 | Insecticidal composition containing emamectin benzoate and chlorempenthrin |
| CN105010384A (en) * | 2015-06-08 | 2015-11-04 | 诺农(北京)国际生物技术有限公司 | Doramectin and pyrethroid insecticide composition |
| CN111011368A (en) * | 2019-11-11 | 2020-04-17 | 南京华洲药业有限公司 | Composite insecticidal and acaricidal nano-water agent containing efficient cyhalothrin and emamectin benzoate and application thereof |
| CN111567551A (en) * | 2020-06-10 | 2020-08-25 | 济南中科绿色生物工程有限公司 | Insecticidal composition and insecticide thereof |
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| CN102017989A (en) * | 2010-12-15 | 2011-04-20 | 广西安泰化工有限责任公司 | Efficient cyhalothrin and emamectin benzoate composition and preparations thereof |
| CN103371154B (en) * | 2012-04-12 | 2016-05-18 | 陕西韦尔奇作物保护有限公司 | The composition pesticide of a kind of fluorine-containing lice sulfanilamide (SN) and biogenic substances |
| CN103371154A (en) * | 2012-04-12 | 2013-10-30 | 陕西韦尔奇作物保护有限公司 | Pesticide combination containing chromafenozid and biological source |
| CN103385254A (en) * | 2012-05-07 | 2013-11-13 | 陕西韦尔奇作物保护有限公司 | Insecticidal composition comprising tefluthrin and biological source |
| CN103004858B (en) * | 2012-11-28 | 2014-04-09 | 李建中 | Insecticidal composition containing methylamino abamectin and pyrethroid compound |
| CN103004858A (en) * | 2012-11-28 | 2013-04-03 | 李建中 | Insecticidal composition containing methylamino abamectin and pyrethroid compound |
| CN103651522A (en) * | 2013-10-31 | 2014-03-26 | 湖南农业大学 | Deltamethrin or composition thereof and application in preventing plant nematodiasis |
| CN103931649A (en) * | 2014-05-05 | 2014-07-23 | 北京市农林科学院 | Insecticidal composition containing emamectin benzoate and chlorempenthrin |
| CN103931649B (en) * | 2014-05-05 | 2015-10-14 | 北京市农林科学院 | The Pesticidal combination of emamectin-benzoate and cholrempenthrin |
| CN105010384A (en) * | 2015-06-08 | 2015-11-04 | 诺农(北京)国际生物技术有限公司 | Doramectin and pyrethroid insecticide composition |
| WO2020174498A1 (en) * | 2019-02-28 | 2020-09-03 | Willowood Chemicals Private Limited | Synergistic insecticidal composition comprising avermectin compound |
| CN111011368A (en) * | 2019-11-11 | 2020-04-17 | 南京华洲药业有限公司 | Composite insecticidal and acaricidal nano-water agent containing efficient cyhalothrin and emamectin benzoate and application thereof |
| CN111567551A (en) * | 2020-06-10 | 2020-08-25 | 济南中科绿色生物工程有限公司 | Insecticidal composition and insecticide thereof |
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