CN1522730A - Rheumathritis capsule preparation method - Google Patents
Rheumathritis capsule preparation method Download PDFInfo
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- CN1522730A CN1522730A CNA031186467A CN03118646A CN1522730A CN 1522730 A CN1522730 A CN 1522730A CN A031186467 A CNA031186467 A CN A031186467A CN 03118646 A CN03118646 A CN 03118646A CN 1522730 A CN1522730 A CN 1522730A
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Abstract
The present invention relates to a preparation method of Chiness medicine capsule preparation in treating wind-dampness syndrome, pain in waist and lower extremities and rheumatoid arthritis. Said preparation method includes the following steps: pulveizing 16 Chinese medicinal materials of ephedra and others to obtain fine powder, mixing the fine powder with nux vomica powder, adding proper quantity of auxiliary material, mixing them uniformly and capsulizing so as to obtain the invented product. Said medicine is safe, stable and obvious of therapeutic effect.
Description
Technical field
This invention relates to the processing technology technical field of Chinese patent medicine capsule, relates in particular to the capsular preparation method of rheumatic arthritis.
Background technology
Capsule is a kind of pharmaceutical formulation commonly used, according to the relevant drug act of China, change dosage form as a kind of new drug research, the capsular original dosage form of rheumatic arthritis is: FENGSHI GUANJIEYAN PIAN, form by 17 flavor Chinese medicines, listed in the 3rd of the Drug Standard of Ministry of Public Health of the Peoples Republic of China " Chinese traditional patent formulation preparation ".The technology features of former dosage form is that the ten Six-element medicated powder such as Herba Ephedrae in the prescription are broken into fine powder, with Semen Strychni (modulation powder) facing-up, adds auxiliary materials and mixing, granulate, and drying, tabletting, sugar coating forms.Tablets, easy to carry, but this product contains volatile ingredient, produce, easily loss and affecting the treatment in the storage, the tablet especially disintegrate of coated tablet needs the long time, affect the treatment, and sugar coating is more loaded down with trivial details, has the low shortcoming of quality control standard simultaneously.Have the shortcoming that influence quality based on former dosage form, we use the modern pharmaceutical technology this product technology are done necessary improvement, form new preparation, improve simultaneously and improve quality standard, guarantee the quality monitoring of product, and the raising curative effect is benefited the common people.
Summary of the invention
The purpose of this invention is to provide the capsular preparation method of a kind of rheumatic arthritis, improve the quality of products and curative effect, satisfy needs of medical treatment better.
The objective of the invention is such realization:
The capsular preparation method of rheumatic arthritis comprises the steps:
One, the capsular prescription of rheumatic arthritis is formed
Semen Strychni (modulation powder) 56-110g Herba Ephedrae 20-110g Radix Angelicae Sinensis 11-20g
Rhizoma Atractylodis 7-14g Radix Dipsaci 7-14g Semen Persicae 7-14g
Flos Carthami 7-14g Olibanum (system) 4-10g Myrrha (processed) 4-10g
Rhizoma Homalomenae 4-10g Cortex Illicii 4-10g Rhizoma Et Radix Notopterygii 4-10g
Pheretima 4-10g Ramulus Cinnamomi 4-10g Squama Manis (system) 4-10g
Fructus Chaenomelis 4-10g Radix Achyranthis Bidentatae 4-10g
Right amount of auxiliary materials is made 1000 altogether.
Its optimum formula is:
Semen Strychni (modulation powder) 56g Herba Ephedrae 56g Radix Angelicae Sinensis 11g
Rhizoma Atractylodis 7g Radix Dipsaci 7g Semen Persicae 7g
Flos Carthami 7g Olibanum (system) 4g Myrrha (processed) 4g
Rhizoma Homalomenae 4g Cortex Illicii 4g Rhizoma Et Radix Notopterygii 4g
Pheretima 4g Ramulus Cinnamomi 4g Squama Manis (system) 4g
Fructus Chaenomelis 4g Radix Achyranthis Bidentatae 4g
Right amount of auxiliary materials is made 1000 altogether.
Two, rheumatic arthritis capsules preparation technique
Except that Semen Strychni (modulation powder), ten Six-element medicines such as all the other Herba Ephedraes clean respectively, remove impurity, and it is standby to be up to the standards.Get ten Six-elements such as Herba Ephedrae and be ground into fine powder,, add adjuvant Semen Strychni (modulation powder) and above-mentioned fine powder facing-up, mixing, encapsulated, quality inspection, packing, promptly.
Three, make by above-mentioned technology and be capsule.
Ten Six-element medicated powder such as technology epheday intermedia were broken into 80-160 purpose fine powder, and the best is that superfine powder is broken into 200-300 purpose fine powder.
Semen Strychni modulation powder method for making in the technology: get Semen Strychni and concoct, rush the unhairing young pilose antler, be ground into fine powder with the stir-baking in sand method.According to " behind the method mensuration strychnine content under the Chinese pharmacopoeia Semen Strychni assay item, it is an amount of to add starch, and making its content is 1.15%, mixing, promptly.
Any or the multiple mixing that adds adjuvant in the technology and can be in micropowder silica gel, starch, the dextrin is used.
After process modification volatile ingredient can obtain preferably keeping and technology easier, its quality standard is also improved comprehensively.Former dosage form does not have qualitative and quantitative index, differentiates now that the thin layer that has increased Radix Angelicae Sinensis, Rhizoma Atractylodis, Flos Carthami, Radix Dipsaci differentiates; Increased heavy metal limit and must not cross 10/1000000ths on checking, arsenic salt must not cross 2/1000000ths; On assay, increased Semen Strychni has been carried out quantitatively.
This invention its superiority compared with the prior art is: production technology more becomes to improving rationally, keeps the volatility active substance better, and technology is easy, and quality standard increases, and makes the quality of product and curative effect that guarantee arranged.
The specific embodiment
The optimum implementation of this invention is that ten Six-element medicines such as all the other Herba Ephedraes clean respectively, remove impurity except that Semen Strychni (modulation powder), and it is standby to be up to the standards.Get ten Six-elements such as Herba Ephedrae and be ground into fine powder,, add adjuvant Semen Strychni (modulation powder) and above-mentioned fine powder facing-up, mixing, encapsulated, quality inspection, packing, promptly.
Claims (1)
1, the capsular preparation method of rheumatic arthritis is characterized in that it may further comprise the steps:
(1) technology epheday intermedia, Radix Angelicae Sinensis, Rhizoma Atractylodis, Radix Dipsaci, Semen Persicae, Flos Carthami, Olibanum, Myrrha, Rhizoma Homalomenae, Cortex Illicii, Rhizoma Et Radix Notopterygii, Pheretima, Ramulus Cinnamomi, Squama Manis, Fructus Chaenomelis, Radix Achyranthis Bidentatae ten Six-element medicated powder were broken into 80-160 purpose fine powder, and the best is that superfine powder is broken into 200-300 purpose fine powder.
(2) Semen Strychni modulation powder method for making in the technology: get Semen Strychni and concoct, rush the unhairing young pilose antler, be ground into fine powder with the stir-baking in sand method.According to " behind the method mensuration strychnine content under the Chinese pharmacopoeia Semen Strychni assay item, it is an amount of to add starch, and making its content is 1.15%, mixing, promptly.
(3) adding adjuvant in the technology can be that any/multiple mixing in micropowder silica gel, starch, the dextrin is used.
(4) with the standby composition of (1), (2), (3) by national drug standards prescription consumption standard feed intake, mixing, encapsulated, the rheumatic arthritis capsule is made in quality inspection.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA031186467A CN1522730A (en) | 2003-02-18 | 2003-02-18 | Rheumathritis capsule preparation method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA031186467A CN1522730A (en) | 2003-02-18 | 2003-02-18 | Rheumathritis capsule preparation method |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1522730A true CN1522730A (en) | 2004-08-25 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNA031186467A Pending CN1522730A (en) | 2003-02-18 | 2003-02-18 | Rheumathritis capsule preparation method |
Country Status (1)
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| CN (1) | CN1522730A (en) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100450527C (en) * | 2006-12-07 | 2009-01-14 | 樊玉仁 | Medicament for treating rheumatism |
| CN101780146B (en) * | 2009-01-19 | 2011-11-23 | 天津达仁堂京万红药业有限公司 | Quality control method of Biqi capsules |
| CN102327532A (en) * | 2011-09-28 | 2012-01-25 | 胡源 | Capsule for treating rheumatism and rheumatoid arthritis |
| CN102038807B (en) * | 2009-10-22 | 2012-05-23 | 天津中新药业集团股份有限公司达仁堂制药厂 | Quality control method of traditional Chinese medicine preparation anti-rheumatoid arthritis pill |
| CN101732413B (en) * | 2008-11-13 | 2012-08-29 | 天津达仁堂京万红药业有限公司 | Chinese medicinal composition for treating arthromyodynia and preparation method thereof |
-
2003
- 2003-02-18 CN CNA031186467A patent/CN1522730A/en active Pending
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100450527C (en) * | 2006-12-07 | 2009-01-14 | 樊玉仁 | Medicament for treating rheumatism |
| CN101732413B (en) * | 2008-11-13 | 2012-08-29 | 天津达仁堂京万红药业有限公司 | Chinese medicinal composition for treating arthromyodynia and preparation method thereof |
| CN101780146B (en) * | 2009-01-19 | 2011-11-23 | 天津达仁堂京万红药业有限公司 | Quality control method of Biqi capsules |
| CN102038807B (en) * | 2009-10-22 | 2012-05-23 | 天津中新药业集团股份有限公司达仁堂制药厂 | Quality control method of traditional Chinese medicine preparation anti-rheumatoid arthritis pill |
| CN102327532A (en) * | 2011-09-28 | 2012-01-25 | 胡源 | Capsule for treating rheumatism and rheumatoid arthritis |
| CN102327532B (en) * | 2011-09-28 | 2013-07-03 | 胡源 | Capsule for treating rheumatism and rheumatoid arthritis |
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