CN1513521A - External use medicine for treating AIDS virus - Google Patents
External use medicine for treating AIDS virus Download PDFInfo
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Abstract
An exterior-applied Chinese medicine for treating dermatopathy and AIDS is prepared from 10 Chinese-medicinal materials including China root, rosin, Chinese angelica root, pearl powder, etc.
Description
Technical field:
The present invention relates to a kind of medicine for external use for the treatment of HIV (human immunodeficiency virus) (Human Immunodeficiency Virus), belong to and a kind ofly can effectively kill HIV (human immunodeficiency virus) (Human Immunodeficiency Virus), kill the dermatosis that causes by HIV (human immunodeficiency virus) (Human Immunodeficiency Virus) and other virus, help improving the medicine of body immunity.
Background technology:
Acquired immune deficiency syndrome (AIDS), english abbreviation is AIDS, it is a kind of acquired immunodeficiency syndrome, it is the general infectious disease that causes by virus, often with lymphadenectasis, anorexia, chronic diarrhea, lose weight, heating, General Symptoms such as weak show, and progressively be developed to various opportunistic infection, secondary tumors, spirit neurological disorder etc. and dead is mainly passed through blood-borne.Many AIDS patients are its first symptom with skin lesion, and mainly contain following three kinds of situations.1, infectious skin performance, OHL, molluscum contagiosum, herpes zoster, cmv infection, HPV infect, the bacilus epithelioid hemangioma, mycobacterial infections, histoplasmosis, cryptococcosis, oral candidiasis, folliculitis, impetigo, mycotic infection of superficial part, the dense bleb folliculitis of acidophilia, syphilis, scabies etc.2, non-infectious cutaneous manifestations has seborrheic dermatitis, psoriasis, the false blood examination induced phlebitis of hyperpathia, reaction rash, vasculitis, drug eruption, granuloma annulare, xeroderma, food deficiency disease, platelet to reduce purpura, telangiectasis, yellow nail etc.3, tumprigenicity cutaneous manifestations has Kaposi sarcoma, lymphoma, cutaneous squamous cell carcinoma, basal cell carcinoma, Asia property melanoma etc.And 64% patient often shows with infectious skin.In a single day above-mentioned skin sex expression appears in HIV sufferers, and particularly, infectious skin performance then can bring skin itching, pain, festers, suppuration etc., brings very big misery to the patient.The scytitis that does not at present also have a kind of Western medicine or Chinese medicine can treat this disease and cause by this disease, and can only slow down symptom, the proper extension life span, and the price of these medicines is expensive especially again, and most of patients does not have economic capability to bear.Therefore, arrived the what is said or talked about acquired immune deficiency syndrome (AIDS) at present, everybody gets degree by complexion changed, and people are afraid of acquired immune deficiency syndrome (AIDS), hide HIV sufferers, can only wait for death in case suffer from acquired immune deficiency syndrome (AIDS).
Summary of the invention:
The technical problem to be solved in the present invention is, provides that a kind of low price, processing technique are simple, raw material is easy to get, can effectively treats scytitis that is caused by HIV (human immunodeficiency virus) (Human Immunodeficiency Virus) and other virus and the medicine for external use that HIV (human immunodeficiency virus) (Human Immunodeficiency Virus) is had auxiliary killing action.
The present invention overcomes the above problems the technical scheme of being taked to be, it is the medicine for external use of being made by following compositions in weight portion that a kind of its effective ingredient is provided.This treatment HIV (human immunodeficiency virus) (Human Immunodeficiency Virus) external the effective elements of the medicine is to be made by following compositions in weight portion basically, Rhizoma Smilacis Glabrae 1.5-10 part, Realgar 1-3.5 part, Calomelas 1-3 part, Semen Hydnocarpi 1.5-5 part, Colophonium 1.5-10 part, Radix Angelicae Sinensis 1.5-5 part, Margarita powder 1.5-5 part, Natrii Sulfas 25-35 part, Plumbum preparatium or Alumen or Hydrocerussitum (Ceruse) 1.5-10 part, Calamina 1.5-10 part.
In its effective ingredient, added Borneolum Syntheticum 0.3-1 part again, Radix Sophorae Flavescentis 1-3.5 part.
In its effective ingredient, added Radix Angelicae Dahuricae 1-3.5 part again.
In its effective ingredient, added Rhizoma Coptidis 1-3.5 part again.
In its effective ingredient, added pyrolusitum 1-3.5 part again, Indigo Naturalis 1.5-5 part.
In its effective ingredient, added sulfur 1-3.5 part again.
In its effective ingredient, Lithargyrum or Hydrargyri Oxydum Rubrum 1-3 part have been added again.
The dosage form of medicine for external use of the present invention can be liquid liniment, also can be the liniment of paste.If liquid liniment, the each component that then needs to constitute effective constituent is put into the fried 3-5 of the container that is filled with water time, and the liquid mixing that each time is fried packs into after evenly and sell use in the bottle, and the content of its medicine is 10-15%.If the liniment of paste, the each component that then at first will constitute effective constituent grinds to form very thin powdery, 1.5-3.5 amount doubly by the active ingredient parts by weight takes by weighing auxiliary components then, and with active princlple and the abundant mix homogeneously of auxiliary components, can sell use in pack into tubular container or the bottle.Used here auxiliary components can be any material among vaseline, Animal fat (as the big oil of pig), the Oleum sesami, the mixture of any two materials or the mixture of their three kinds of materials; Also can be any material among vaseline, Animal fat, the Oleum sesami, the mixture of any two materials or the mixture of their three kinds of materials, with the mixed material of starch.It can also be other material that can be used as pharmacy unguentum auxiliary components.
Because the present invention is a Chinese medicine preparation, the active component of preparation is Chinese herbal medicine entirely, and component compatibility is reasonable.It is based on antiviral, treating the poisonous disease with poisonous drugs and draw out pus by applying a plaster to the affected part, and is auxilliary with heat clearing away, antiinflammatory, detoxifcation, expelling pus and promoting granulation, reparation skin function.Antiviral, treating the poisonous disease with poisonous drugs and the Chinese medicine component of drawing out pus by applying a plaster to the affected part mainly contain, Realgar, Calomelas, Semen Hydnocarpi, Colophonium, Plumbum preparatium or Alumen or Hydrocerussitum (Ceruse), Natrii Sulfas, Calamina.
Realgar: have removing toxic substances and promoting subsidence of swelling, removing dampness and killing parasites effect.Carbuncle scabies infections, herpes zoster, eczema, tinea scabies, neurodermatitis etc. there is curative effect preferably.
Calomelas: have hold back the skin ulcer parasite killing, the effect of the relieving constipation of relieving oedema or abdominal distension through diuresis or purgation.To skin infection fester, seep water suppurate, prolonged more than and scabies infects, scratching where it itches to fester has better curative effect.
Semen Hydnocarpi: have dispel the wind, insecticidal action.Control illness such as scabies sore, urticaria, leprosy.
Colophonium: have the evacuation of pus of drawing out pus by applying a plaster to the affected part, killing parasites for relieving itching effect.System carbuncle furuncle, toxic swelling ulcer, wound are festered, illness such as pus is dripping, scabies eczema, skin itching.
The Plumbum preparatium: relieving palpitation weighs down expectorant, preventing the attack (or recurrence) of malaria removing food stagnancy, drawing out pus by applying a plaster to the affected part rises that flesh, removing dampness are held back skin ulcer, parasite killing is treated tinea.
Alumen: dampness expectorant, parasite killing, detoxifcation, hemostasis.Treat malicious malignant boil, expectorant prolongs to stop up contains scabies etc.
Hydrocerussitum (Ceruse): draw out pus by applying a plaster to the affected part and rise flesh, removing dampness is held back skin ulcer.
Natrii Sulfas: dispelling malignant blood detoxifcation.Disease is gathered during system, dryness accumulated in the stomach and intestine feeling of fullness, skin ulcer be swollen.
Calamina: have removing dampness and hold back the effect that skin ulcer, removing nebula make eye bright.Control eczema itch disease, skin infection burst for a long time do not heal, pus is dripping, bitterly, all diseases of itching.
Component with heat clearing away, antiinflammatory, detoxifcation, expelling pus and promoting granulation, reparation skin function mainly contains Rhizoma Smilacis Glabrae, Radix Angelicae Sinensis, Margarita powder.
Rhizoma Smilacis Glabrae: have effects such as antiinflammatory, antibacterial, antitumor, detoxifcation.
Radix Angelicae Sinensis: have antiinflammatory, analgesia, heat-clearing and toxic substances removing, promoting blood circulation to remove blood stasis, blood tonification effect nourishes blood.
Margarita powder: have draw out pus by applying a plaster to the affected part, the effect of closing in, granulation promoting, heat-clearing and toxic substances removing.
The mutual synergism of above each component, make that this medical instrument has that comprehensive heat-clearing and toxic substances removing, treating the poisonous disease with poisonous drugs, removing dampness are antipruritic, removing dampness and killing parasites, anti-inflammation detumescence, cooling blood for hemostasis, pain relieving, expelling pus and promoting granulation, go speckle to go dead flesh to dislike meat, repair the function of skin function, can treat the various dermatosiss that any disease causes, and the maximum characteristics of this medicine are, can treat the various dermatosiss that acquired immune deficiency syndrome (AIDS) causes and kill HIV (human immunodeficiency virus) (Human Immunodeficiency Virus), it is the effectively auxiliary medicine for external use that the treatment acquired immune deficiency syndrome (AIDS) causes dermopathic main medicine and treatment HIV (human immunodeficiency virus) (Human Immunodeficiency Virus).And improve HIV AIDS aids patient General Symptoms, remove weakly, treatment diarrhoea, eliminate aspects such as liver, stomach, osteodynia significant curative effect arranged.Clinical treatment 120 routine HIV (human immunodeficiency virus) patients show, aspect the dermatosis that causes of treatment HIV (human immunodeficiency virus) (Human Immunodeficiency Virus), this medicine effective percentage has reached 100%, and cure rate reaches 93%.Aspect the treatment HIV (human immunodeficiency virus) (Human Immunodeficiency Virus), the effective percentage of this medicine has also reached 100%, and obvious effective rate reaches 87.5%.By the various treating skin diseases to causing because of other condition of illness, its effective percentage is 100%, and cure rate is 98%.
The routine HIV (human immunodeficiency virus) patient's situations explanation 1 of clinical treatment 120, patient select: 89 of male patients, account for 74.2%, and 31 of female patients account for 25.8%, and wherein 8-15 year patient is 10, accounts for 110 of 8.3%, 20 to 55 years old patients, accounts for 91.7%.(1) herpes simplex pox patient is 20, and wherein the male patient is 15,5 of female patients; (2) the herpes zoster patient is 30, and wherein the male patient is 23,7 of female patients; (3) the cmv infection patient is 20, and wherein the male patient is 17,3 of female patients; (4) bacilus epithelioid hemangioma infected patient is 10, and wherein men and women patient is each 5; (5) psoriatic is 10, and wherein the male patient is 6,4 of female patients; (6) the syphilis patient is 20, and wherein the male patient is 15,5 of female patients; (7) other std patients are 10, and wherein the male patient is 8,2 of female patients.
2, the diagnostic criteria of disease:
If, at first judge whether to be HIV sufferers, treat according to the external disease medication of patient skin then as the treatment acquired immune deficiency syndrome (AIDS).
2.1 the diagnosis of HIV sufferers.Every have one of following symptom person promptly to be diagnosed as to suffer from acquired immune deficiency syndrome (AIDS):
Infect 2.1.1 laboratory has been made a definite diagnosis HIV (human immunodeficiency virus) (HIV), and be less than 200 or CD4 lymphocyte with every cubic millimeter of blood cd4 cell number and be lower than 14%.
2.1.2 the HIV (human immunodeficiency virus) (HIV) of having made a definite diagnosis laboratory infects and with following clinical manifestation person.Bronchus and trachea pulmonary candidiasis infect, the esophagus monilial infection, the wellability cervical cancer, dissemination and coccidioidomycosis of lung, the outer coccidiosis of lung, non-liver, spleen and lymph-node cell virus disease, with the cytomegaloviral retinitis of visual loss, the chronic ulcer that HIV (human immunodeficiency virus) dependency encephalopathy, simple scar exanthema virus cause.
2.2 the skin clinical diagnosis of HIV sufferers.
2.2.1 infectious skin clinical diagnosis.2.2.1.10HL the clinical diagnosis diagnostic criteria.A, be positioned at the white infringement of tongue lateral edges, b, plate can not be wiped infringement, and c, plate are a mao shape appearance, and d, antifungal are failed to respond to any medical treatment, and e, the distinctive histologic characteristics of OHL are arranged.2.2.1.2 the clinical diagnosis standard of molluscum contagiosum.The molluscum contagiosum of HIV sufferers is sent out well in buccal portion, and central authorities have the recessed hemispherical pimple of umbilicus often to extend to scalp, forehead rapidly, form ulcer once in a while.2.2.1.3 herpes zoster and herpes simplex clinical diagnosis standard.Its infringement face of herpes simplex of HIV sufferers tends to facial destructiveness and persistency, and its infringement is very serious usually, shows as long-standing rotten to the corn face or ulcer, even causes unmaking.Sometimes be dissemination impetigo sample, be general chickenpox or atoipc dermatitis, fallen leaves bleb skin ulcer, the sick sample rash of Darier individually.The herpes zoster of HIV sufferers often causes intractable headache, and skin lesion is the chickenpox shape sometimes, can reach more than 2000 chickenpox shape.2.2.1.4CMV infect the clinical diagnosis diagnostic criteria.CMV is a kind of DNA viruses, belongs to herpetoviridae.The modal cutaneous manifestations of cmv infection is a crissum persistency skin ulcer.The skin lesion of dissemination cmv infection can be positioned at crissum, mucous membrane of rectum, perineum, shank and thigh, show as boundary clearly ulcer, hardening pigmentation tuberosity or speckle, the dissemination erythra of the pimple of developing into, purpura, chickenpox, bulla tendency is arranged, tongue, oral mucosa and pharyngeally also ulcer and necrosis can take place.2.2.1.5HPV infect the clinical diagnosis diagnostic criteria.The immunocompromised patient skin infection shows as multiple, usually is general property wart sometimes, comprises that palpus portion verruca plana and verruca filiformis, general property open up wart and first Zhou Ronghe wart.2.2.1.6 the bacilus epithelioid hemangioma infects the clinical diagnosis diagnostic criteria.This sick modal performance is to be dispersed in or general property skin erythema purulent granuloma sample infringement.Mucosa also can involve, and infringement can be invaded and corium, subcutaneus adipose tissue or the tissue of position, deep more.2.2.1.7 mycobacterial infections clinical diagnosis diagnostic criteria.Most typical performance is ill-defined macule and depigmentation in the bacillus infection of the interior bird type branch of cell.In tissue pathology checking's visible tissue cell the acid-resisting pathogen is arranged.2.2.1.8 the sick clinical diagnosis diagnostic criteria of histiocyte slurry bacterium.Pimple appears being dispersed in patient's palm, sufficient edge, and pimple central authorities have one jiao to fasten.Skin biopsy is looked the reflection of granulation central authorities and a large amount of spore, turns out to be histoplasmosis through cultivation.2.2.1.9 prunus mume (sieb.) sieb.et zucc. degree clinical diagnosis standard.Prunus mume (sieb.) sieb.et zucc. degree patient is preferably directly done skin histopathology's inspection or organizes dark-field microscopy with skin lesion.
2.2.2 non-infectious skin clinical diagnosis.2.2.2.1 the diagnostic criteria of seborrheic dermatitis.HIV sufferers seborrheic dermatitis has unique pathologic to change, and comprises dispersivity parakeratosis with the difference of ordinary property seborrheic dermatitis, is not limited to the follicular orifice edge; Satellite shape epithelial cells bosom is dead, the corium vessel wall thickening.Plasmacytosis and the necrosis of kitchen range lymphocyte.2.2.2.2 psoriatic diagnostic criteria.The lymphocytic quantity of T reduces in the psoriatic lesion of HIV sufferers, and the plasma cell composition significantly raises.2.2.2.3 the diagnostic criteria of the false blood examination induced phlebitis of hyperpathia.Can there be the instep to swell, show as single lower limb before the onset, particularly shank height swelling, the sample severe pain of lancinating.The local skin pale red, skin temperature raises.The most special performance is that skin of lower extremity tenderness highly significant even behind skin turgor and erythema shank, still can exist, is taken non-Aeroseb-Dex and only can partly be alleviated.2.2.2.4 reaction rash diagnostic criteria.Be a kind of special, erythra of being chronic process, for several to hundreds of diameters be the skin rashes that the 2-5mm size does not merge mutually, be distributed in head, neck and trunk top, with pruritus.How much skin is genuine changes with the course of disease, and most patient's skin lesion are sustainable more than 9 months.2.2.2.5 vasculitic diagnostic criteria.The immunofluorescence check result finds that complement precipitation, anti-CMV negative antibody, anti-HTLV antibody positive are arranged in the blood vessel.2.2.2.6 acquired ichthyosis diagnostic criteria.Acquired ichthyosis shows as in the AIDS course of disease and drives, the big lamellar adhesive scale of extremity generation dispersivity, does not involve fold place, can accompany the palm (sole of the foot) keratinization.2.2.2.7 the diagnostic criteria of yellow nail syndrome.Quite a lot of patient has the yellow nail syndrome among patient AIDS of Ka Shi lung robe worm pneumonia.Its performance is different with classical yellow nail syndrome, particularly part first far-end flavescence of fingernail, and companion's first muddiness, lunula disappear and the first ridge, do not thicken and onycholysis, disengaging and there is significant first.
3, treatment standard:
3.1 the treatment standard of acquired immune deficiency syndrome (AIDS).Regulation according to present treating AIDS standard is carried out.Be any medicine or therapy as long as every cubic millimeter of peripheral blood increase of cd4 cell number of patient is judged to more than 50 effectively, otherwise be invalid.If being increased to, every cubic millimeter of peripheral blood of cd4 cell number of patient then is produce effects more than 140.Infect if treatment made the patient not have human immunity defective virus (HIV) to a year and a half in 1 year, every cubic millimeter of blood cd4 cell number is higher than 14% greater than 600 or CD4 lymphocyte, then be basic healing.
3.2 HIV (human immunodeficiency virus) (Human Immunodeficiency Virus) causes the treating for skin disease standard.With this medicine treatment 3.5-7 days, skin affected part sx, and develop into effectively to the rehabilitation direction gradually; With this medicine treatment 30-70 days, skin affected part transference cure, it is normal that skin recovers, and 1-1.5 not the recidivist for curing.
4, the treatment course of treatment and administrated method:
4.1 treat the course of treatment:
4.1.1 the course of treatment of treatment acquired immune deficiency syndrome (AIDS), two months is a course of treatment.
4.1.2 the treatment HIV (human immunodeficiency virus) (Human Immunodeficiency Virus) causes the dermopathic course of treatment, 7 days is a course of treatment.
4.2 administrated method: preceding 7 day every day, coating was 1-2 time, later on every 3 days coatings once.It is relevant with affected part area size to be coated with dose, is as the criterion with even covering affected part.
5, therapeutic outcome:
5.1 the result of treatment acquired immune deficiency syndrome (AIDS).Totally 120 of the patients who receives treatment smear this medicine after 8 weeks, and every cubic millimeter of peripheral blood of its cd4 cell number has all increased more than 80, and what have has reached 135, and effective percentage is 100%.Have 105 patients to smear this medicine after 12 weeks, every cubic millimeter of peripheral blood of its cd4 cell number has on average increased more than 165, and obvious effective rate is 87.5%.
5.2 the treatment HIV (human immunodeficiency virus) (Human Immunodeficiency Virus) causes dermopathic result.Totally 120 of the patients who receives treatment smeared this medicine treatment 3.5-21 days, and skin affected part symptom significantly alleviates, and skin rehabilitation face 30% above person is 120, and effective percentage reaches 100%.With this medicine treatment 30-70 days, the symptom complete obiteration of skin affected part, and recover normal, and the patient that 1-1.5 does not recur is 112, cure rate reaches 93%.Wherein the herpes simplex patient is 20; 30 of herpes zoster patients; 20 of cmv infection patients; 10 of bacilus epithelioid hemangioma infected patients; The psoriatic 10; (6) the syphilis patient is 20; 10 of other std patients.And, treat dermopathic medicine at present, as the Eloson emulsifiable paste, compound recipe receive happy frost, norfloxacin emulsifiable paste, Ai Like, Pi Qingshuan, compound recipe health frost, Bai Niduo, Suo Kang cream, mupirocin, Mupirocin Ointment daktarin, PIYANPING, psoriasis paster, sweep the spirit of itching, PIKANG SHUANG etc., the dermatosis that causes because of acquired immune deficiency syndrome (AIDS) only there is certain curative effect, just recurrence in drug withdrawal 2-7 days.Severe patient must drop the antibiotic medicine treatment, but also can only respite, in case stop antiinflammatory, dermatosis recurs again.Cause dermopathic situation with this medicine treatment acquired immune deficiency syndrome (AIDS) itself and acquired immune deficiency syndrome (AIDS), see treatment statistical result table 1 and table 2 for details:
The treatment acquired immune deficiency syndrome (AIDS) is statistical table as a result: table 1
| Patient's number | Coating is after 8 weeks | Coating is after 12 weeks | ||||||
| Every cubic millimeter of blood CD4 cell number | Therapeutic outcome percent | Every cubic millimeter of blood CD4 cell number | Therapeutic outcome percent | |||||
| 120 | The man | 89 account for 74.2% | 8-15 year | 6 | ?95-135 | ?100％ | ?165-200 | ?87.5％ |
| 20-55 year | 83 | ?80-110 | ?165-191 | |||||
| The woman | 31 account for 25.8% | 8-15 year | 4 | ?95-135 | ?165-200 | |||
| 20-55 year | 27 | ?80-110 | ?165-190 | |||||
Treatment acquired immune deficiency syndrome (AIDS) dermatosis is statistical table as a result: table 1
| Patient's sum | Dermatosis title and patient's number | Skin clinical symptoms before the treatment | Coating treatment 3.5-7 days | Coating treatment 30-70 days and 1-1.5 do not recur | ||||
| Treatment back skin clinical symptoms | Number | Effective percentage | Treatment back skin clinical symptoms | Number | Cure rate | |||
| 120 | 20 herpes zoster patients of herpes simplex patient | The dissemination impetigo sample skin lesion that is that rotten to the corn face or ulcer have is chickenpox | Rotten to the corn face or ulcer surface dwindle, and there is new skin more than 30% to grow to cause skin lesion in the affected part | 20 30 | 100 % | Rotten to the corn face or ulcer surface disappear, skin recovers normal chickenpox and disappears | 18 28 | 112, cure rate reaches 93% |
| 30 | Shape | Chickenpox reduces or diminishes, and the rehabilitation face of skin lesion reaches more than 30. | It is normal that skin recovers | |||||
| 20 of cmv infection patients | Boundary is the dissemination erythra of ulcer, pimple, purpura, chickenpox, bulla tendency clearly | The dissemination erythra of ulcer, pimple, purpura, chickenpox, bulla tendency obviously reduces, and skin changes to the healing direction | 20 | Dermatosiss such as ulcer, pimple, purpura, chickenpox, bulla disappear, and it is normal that skin recovers | 18 | |||
| 10 of bacilus epithelioid hemangioma infected patients | Skin erythema, the infringement of purulent granuloma sample | Skin erythema, the infringement of purulent granuloma sample obviously reduce. | 10 | The complete obiteration of skin lesion symptom, skin recover normal | 9 | |||
| The psoriatic 10 | The generalized erythroderma psoriasis | The generalized erythroderma psoriasis reduces, and skin begins to recover | 10 | The generalized erythroderma psoriasis disappears, and it is normal that skin recovers | 10 | |||
| 20 of syphilis patients | For III phase syphilis, blood vessel, nerve damage appear. | III phase syphilis begins its transformation to II I, and blood vessel, nerve evil obviously reduce | 20 | Syphilis transference cure, skin recover normal | 19 | |||
| 10 of other std patients | There is not significant difference with general patient's skin symptom | Symptom such as erythra, redness obviously reduces | 10 | Transference cure such as erythra, redness, skin recover normal | 10 | |||
Model case is introduced:
1, open * *, the woman, 33 years old, people from Yangchuan village behind the Shao Dian township, Shangcai County, Henan Province found that HIV becomes the positive 4 years.Diarrhoea, heating, weak, hyperhidrosis are arranged, skin itching, symptoms such as myalgia, arthralgia.Head, facial seborrheic dermatitis, there is herpes the subregion of health, 12 kilograms of weight loss.Used the Eloson emulsifiable paste once, compound recipe is received scytitiss such as treatment dermatitis, eczema such as happy frost, norfloxacin emulsifiable paste, Ai Like, Pi Qingshuan, but has little effect, and after one week of drug withdrawal, recurs again.On June 6th, 2002 treated with this medicine, and after 5 days, symptoms such as skin sufferings, headache, arthralgia take a turn for the better and scratch where it itches, pain obviously alleviates.Continue treatment with this medicine, after accumulative total reached 45 days, the various symptoms of skin all disappeared, so far gun-ho.
2, open * *, the woman, 32 years old, people from Yangchuan village behind the Shao Dian township, Shangcai County, Henan Province found that HIV becomes the positive 3 years.Herpes zoster, chickenpox are arranged, and herpes place pain, can not walk, low grade fever, diarrhoea are arranged for a long time, 17 kilograms of weight loss.Once used medicine treatment dermatosiss such as the healthy frost of compound recipe, Bai Niduo, Suo Kang cream, mupirocin, Mupirocin Ointment, but DeGrain.Began on May 16th, 2002, can walk down after 3 days with the treatment of this medicine, behind the fortnight, scytitis and headache, skelalgia disappear substantially.Continue with the treatment of this medicine after 30 days, every index is normal, so far not recurrence.
3, open * *, the man, 29 years old, people from Yangchuan village behind the Shao Dian township, Shangcai County, Henan Province found that HIV becomes the positive 3 years.Whole body suffers from erythra, local psoriasis, the eczema suffered from, with headache, weak, symptom such as scratch where it itches.8 kilograms of weight loss.Once used treatment dermatosiss such as sicorten plus, mometasone emulsifiable paste, compound recipe Kang Na frost, ciprofloxacin ointment, Airy gram.But DeGrain, and just recurrence after the drug withdrawal.Began on August 11st, 2002 with the treatment of this medicine, after 6 days, General Symptoms begins to be clearly better, and partial symptoms begins to disappear.After treating 56 days with this medicine continuously, the various transference cures of whole body, recurrence so far.
4, journey * *, the man, 33 years old, Lu Gang township, Shangcai County, Henan Province Wen Lou people from village found that HIV becomes the positive 4 years.Face, general seborrheic dermatitis, herpes, impetigo are arranged, and whole body scratches where it itches, weak.7 kilograms of weight loss.Once used Eloson emulsifiable paste, the strong treatment of compound recipe frost, Bai Niduo, auspicious health ointment, norfloxacin emulsifiable paste etc., but had little effect, and frequent recurrence.Began on June 5th, 2003 with this medicine treatment, after 3 days, General Symptoms begins to take a turn for the better, and continuously with the treatment of this medicine after 30 days, the various transference cures of whole body recur so far.
5, the king * *, the man, 36 years old, Lu Gang township, Shangcai County, Henan Province Wen Lou people from village found that HIV becomes the positive 3 years.Tinea manus and pedis, erythra, herpes etc. are arranged, and whole body is scratched where it itches and with headache, diarrhoea etc.Once used sicorten plus, Pi Qingshuan, MEIBAO PIKANG SHUANG etc., but had little effect, and drug withdrawal i.e. recurrence after 7 days.Began on June 5th, 2003 with this medicine treatment, after 5 days, General Symptoms obviously alleviates, treat 30 days with this medicine continuously after, the various transference cures of whole body, all symptoms are good so far.
The specific embodiment:
Manufacture process below in conjunction with medicine for external use provides embodiments of the invention, is used for further specifying technical solution.
Embodiment 1: raw material and processing method that desire processing external the effective elements of the medicine 5.1kg (51 parts, every part by 100g calculating) chooses are as follows:
1, weighing component: at first take by weighing clean, pure Rhizoma Smilacis Glabrae 500g (5 parts), Realgar 100g (1 part), Calomelas 150g (1.5 parts), Semen Hydnocarpi 200g (2 parts), Colophonium 500g (5 parts), Radix Angelicae Sinensis 300g (3 parts), Margarita powder 300g (3 parts), Natrii Sulfas 2600g (26 parts), Plumbum preparatium 150g (1.5 parts), Calamina 300g (3 parts).2, grind and mix: then the measured above Chinese medicinal components of scale is ground to form fine powder, and it is fully mixed.3, processing ointment: the ratio that is 1.5 times of effective ingredient weight at first by weight, take by weighing vaseline 7.65kg, then 7.65kg vaseline being put into container melts, again the 5.1kg effective ingredient is put into the vaseline of thawing, and make their abundant mix homogeneously, make ointment, by every bottle of 100g-500g ointment bottling.Preceding 7 day every day, coating was 1-2 time, later on every 3 days coatings once.During coating, medicine is evenly covered the affected part.Because the used active component of present embodiment mainly is detoxifcation, draws out pus by applying a plaster to the affected part and the medicine of removing the necrotic tissue life; and heat clearing away, detoxifcation and antiinflammatory and skin is had the composition of protective effect; Rhizoma Smilacis Glabrae, Margarita powder and Radix Angelicae Sinensis are only arranged; therefore; protective effect to skin is relatively poor relatively, so not too suit to smear continuously, smears once preferably lasting 10-12 hour in preceding 7 days; then medicine is washed off, smeared next time again in 10-12 hour at interval.
Embodiment 2: it is as follows that desire processing contains raw material and processing method that the medicine for external use 6.33kg (63.3 parts, every part by 100g calculating) of effective composition chooses:
1, weighing component: at first take by weighing clean, pure Rhizoma Smilacis Glabrae 800g (8 parts), Realgar 150g (1.5 parts), Calomelas 100g (1 part), Semen Hydnocarpi 500g (5 parts), Colophonium 300g (3 parts), Radix Angelicae Sinensis 150g (1.5 parts), Margarita powder 500g (5 parts), Natrii Sulfas 3000g (30 parts), Alumen 300g (3 parts), Calamina 150g (1.5 parts), Borneolum Syntheticum 30g (0.3 part), Radix Sophorae Flavescentis 350g (3.5 parts).2, grind and mix: then above Chinese medicinal components is ground to form fine powder, and it is fully mixed.3, processing ointment: the ratio that is 2 times of effective ingredient weight at first by weight, take by weighing vaseline 12.66kg, then 12.66kg vaseline being put into container melts, again the 6.33kg effective ingredient is put into and melted good vaseline, and make their abundant mix homogeneously, make ointment, by every bottle of 100g-500g ointment bottling.The coating Therapeutic Method is identical with embodiment 1.Because present embodiment is compared with embodiment 1, increased that having has one's ideas straightened out and refreshed oneself, the Borneolum Syntheticum of clearing away heat to alleviate pain effect, Radix Sophorae Flavescentis with heat-clearing and toxic substances removing, diuresis insecticidal action, and increased have draw out pus by applying a plaster to the affected part, the content of closing in, granulation promoting, antipyretic and antidote functions Margarita powder, simultaneously, replaced the Plumbum preparatium with Alumen, so, the analgesic antiphlogistic effect is than embodiment the last 1, preceding 7 days smear number of times and can increase relatively.
Embodiment 3.It is as follows that desire processing contains raw material and processing method that the medicine for external use 6.5kg (65 parts, every part by 100g calculating) of effective composition chooses:
1, at first takes by weighing clean, pure Rhizoma Smilacis Glabrae 150g (1.5 parts), Realgar 200g (2 parts), Calomelas 200g (2 parts), Semen Hydnocarpi 150g (1.5 parts), Colophonium 1000g (10 parts), Radix Angelicae Sinensis 500g (5 parts), Margarita powder 150g (1.5 parts), Natrii Sulfas 2800g (28 parts), Hydrocerussitum (Ceruse) 500g (5 parts), Calamina 500g (5 parts), Radix Angelicae Dahuricae 350g (3.5 parts).2, grind and mix: then above Chinese medicinal components is ground to form fine powder, and it is fully mixed.3, processing ointment: the ratio that is 2.5 times of effective ingredient weight at first by weight, take by weighing vaseline 16.25kg, then 16.25kg vaseline being put into container melts, again the 6.5kg effective ingredient is put into and melted good vaseline, and make their abundant mix homogeneously, make ointment, by every bottle of 100g-500g ointment bottling.The coating Therapeutic Method is identical with embodiment 1.Because present embodiment is compared with embodiment 1, has increased the Radix Angelicae Dahuricae with diffusing wind dehumidifying, understand things pain-stopping, detumescence and apocenosis effect, and has replaced the Plumbum preparatium with Hydrocerussitum (Ceruse), so the analgesic antiphlogistic effect is good than embodiment 1.
Embodiment 4.It is as follows that desire processing contains raw material and processing method that the medicine for external use 7.7kg (77 parts, every part by 100g calculating) of effective composition chooses:
1, at first takes by weighing clean, pure Rhizoma Smilacis Glabrae 1000g (10 parts), Realgar 350g (3.5 parts), Calomelas 250g (2.5 parts), Semen Hydnocarpi 200g (2 parts), Colophonium 150g (1.5 parts), Radix Angelicae Sinensis 150g (1.5 parts), Margarita powder 200g (2 parts), Natrii Sulfas 3400g (34 parts), Plumbum preparatium 700g (7 parts), Calamina 1000g (10 parts), Borneolum Syntheticum 100g (1 part), Radix Sophorae Flavescentis 100g (1 part), Radix Angelicae Dahuricae 100g (1 part).2, grind and mix: then above Chinese medicinal components is ground to form fine powder, and it is fully mixed.3, processing ointment: the ratio that is 3 times of effective ingredient weight at first by weight, take by weighing Animal fat (as the big oil of pig) 23.1kg, then the 23.1kg Animal fat being put into container melts, again the 7.7kg effective ingredient is put into and melted good Animal fat, and make their abundant mix homogeneously, make ointment, by every bottle of 100g-500g ointment bottling.The coating Therapeutic Method is identical with embodiment 1.Because present embodiment compares with embodiment 2, increased the Radix Angelicae Dahuricae, so analgesic antiphlogistic, granulation promoting effect are good than embodiment 2 with diffusing wind dehumidifying, understand things pain-stopping, detumescence and apocenosis effect.
Embodiment 5.It is as follows that desire processing contains raw material and processing method that the medicine for external use 7.88kg (78.8 parts, every part by 100g calculating) of effective composition chooses:
1, at first takes by weighing clean, pure Rhizoma Smilacis Glabrae 700g (7 parts), Realgar 200g (2 parts), Calomelas 300g (3 parts), Semen Hydnocarpi 300g (3 parts), Colophonium 700g (7 parts), Radix Angelicae Sinensis 400g (4 parts), Margarita powder 300g (3 parts), Natrii Sulfas 2800g (28 parts), Alumen 1000g (10 parts), Calamina 800g (8 parts), Borneolum Syntheticum 80g (0.8 part), Radix Sophorae Flavescentis 200g (2 parts), Rhizoma Coptidis 100g (1 part).2, grind and mix: then above Chinese medicinal components is ground to form fine powder, and it is fully mixed.3, processing ointment: the ratio that is 3 times of effective ingredient weight at first by weight, take by weighing Oleum sesami 23.64kg, then 23.64kg Oleum sesami is put into container, and adding 7.88kg effectively becomes powder in it, constantly stir simultaneously, make their abundant mix homogeneously, make ointment, by every bottle of 100g-500g ointment bottling.The coating Therapeutic Method is identical with embodiment 1.Because present embodiment is compared with embodiment 2, increased to have staphylococcus, streptococcus, streptococcus pneumoniae, cholera have been opened the Rhizoma Coptidis that bacterium, anthrax bacillus etc. all have strong antibacterial action, and can effectively promote the effect of skin histology healing.So analgesic antiphlogistic, granulation promoting effect are better than embodiment 2.
Embodiment 6: it is as follows that desire processing contains raw material and processing method that the medicine for external use 8.05kg (80.5 parts, every part by 100g calculating) of effective composition chooses:
1, at first takes by weighing clean, pure Rhizoma Smilacis Glabrae 600g (6 parts), Realgar 300g (3 parts), Calomelas 200g (2 parts), Semen Hydnocarpi 200g (2 parts), Colophonium 600g (6 parts), Radix Angelicae Sinensis 500g (5 parts), Margarita powder 400g (4 parts), Natrii Sulfas 3200g (32 parts), Alumen 800g (8 parts), Calamina 400g (4 parts), Borneolum Syntheticum 50g (0.5 part), Rhizoma Coptidis 200g (2 parts), pyrolusitum 100g (1 part), Indigo Naturalis 500g (5 parts).2, grind and mix: then above Chinese medicinal components is ground to form fine powder, and it is fully mixed.3, processing ointment: the ratio that is 2.5 times of effective ingredient weight at first by weight, take by weighing Oleum sesami 20.2kg, then 20.2kg Oleum sesami is put into container, and in it, add the 8.05kg effective ingredient, constantly stir simultaneously, make their abundant mix homogeneously, make ointment, by every bottle of 100g-500g ointment bottling.The coating Therapeutic Method is identical with embodiment 1.Because present embodiment is compared with embodiment 2, staphylococcus, streptococcus, streptococcus pneumoniae, cholera are opened the Rhizoma Coptidis that bacterium, anthrax bacillus etc. all have strong antibacterial action replaced Radix Sophorae Flavescentis with having, increased pyrolusitum with removing dampness, granulation promoting, removing heat from blood, pain relieving, anastalsis, with Indigo Naturalis with heat-clearing and toxic substances removing, cooling blood for hemostasis effect, so, antiinflammatory, sterilize, draw out pus by applying a plaster to the affected part, promoting muscle growth functions is better than embodiment 2.
Embodiment 7: it is as follows that desire processing contains raw material and processing method that the medicine for external use 7.92kg (79.2 parts, every part by 100g calculating) of effective composition chooses:
1, at first takes by weighing clean, pure Rhizoma Smilacis Glabrae 200g (2 parts), Realgar 150g (1.5 parts), Calomelas 150g (1.5 parts), Semen Hydnocarpi 300g (3 parts), Colophonium 400g (4 parts), Radix Angelicae Sinensis 450g (4.5 parts), Margarita powder 500g (5 parts), Natrii Sulfas 3000g (30 parts), Hydrocerussitum (Ceruse) 400g (4 parts), Calamina 600g (6 parts), Borneolum Syntheticum 70g (0.7 part), Radix Angelicae Dahuricae 200g (2 parts), Rhizoma Coptidis 350g (3.5 parts), Radix Sophorae Flavescentis 300g (3 parts), pyrolusitum 350g (3.5 parts), Indigo Naturalis 150g (1.5 parts), sulfur 350g (3.5 parts).2, grind and mix: then above Chinese medicinal components is ground to form fine powder, and it is fully mixed.3, processing ointment: the ratio that is 3.5 times of effective ingredient weight at first by weight, take by weighing vaseline 27.72kg, take by weighing starch 2.6kg, then 27.72kg vaseline is put into container and heating and melting, and in it, add 7.92kg effective ingredient and 2.6kg starch, and constantly stir simultaneously, make their abundant mix homogeneously, make ointment, by every bottle of 100g-500g ointment bottling.The coating Therapeutic Method is identical with embodiment 1.Because present embodiment is compared with embodiment 6, increased the Radix Angelicae Dahuricae with diffusing wind dehumidifying, understand things pain-stopping, detumescence and apocenosis effect, Radix Sophorae Flavescentis with heat-clearing and toxic substances removing, diuresis insecticidal action, sulfur with detoxifcation, parasite killing, the effect of treatment skin ulcer, so, antiinflammatory, sterilize, draw out pus by applying a plaster to the affected part, promoting muscle growth functions is better than embodiment 6.Simultaneously in the helper component, increase starch after, both increased the adhesive effect of medicine, help again and the combining of skin, simultaneously, skin has been played certain moistening and protective effect.
Embodiment 8: it is as follows that desire processing contains raw material and processing method that the medicine for external use 8.55kg (85.5 parts, every part by 100g calculating) of effective composition chooses:
1, at first takes by weighing clean, pure Rhizoma Smilacis Glabrae 800g (8 parts), Realgar 300g (3 parts), Calomelas 250g (2.5 parts), Semen Hydnocarpi 250g (2.5 parts), Colophonium 800g (8 parts), Radix Angelicae Sinensis 400g (4 parts), Margarita powder 450g (4.5 parts), Natrii Sulfas 2600g (26 parts), Hydrocerussitum (Ceruse) 600g (6 parts), Calamina 500g (5 parts), Borneolum Syntheticum 100g (1 part), Radix Angelicae Dahuricae 250g (2.5 parts), Rhizoma Coptidis 200g (2 parts), Radix Sophorae Flavescentis 350g (3.5 parts), pyrolusitum 200g (2 parts), Indigo Naturalis 300g (3 parts), sulfur 100g (1 part), Hydrargyri Oxydum Rubrum 100g (1 part).2, grind and mix: then above Chinese medicinal components is ground to form fine powder, and it is fully mixed.3, processing ointment: the ratio that is 3.5 times of effective ingredient weight at first by weight, take by weighing vaseline 29.925kg, take by weighing starch 3.2kg, then 29.925kg vaseline is put into container and heating and melting, and in it, add 8.55kg effective ingredient and 3.2kg starch, and constantly stir simultaneously, make their abundant mix homogeneously, make ointment, by every bottle of 100g-500g ointment bottling.The coating Therapeutic Method is identical with embodiment 1.Because present embodiment compares with embodiment 7, increased have healing up sore and subduing swelling, damp eliminating deodorant Hydrargyri Oxydum Rubrum, so, antiinflammatory, subside a swelling, draw out pus by applying a plaster to the affected part, promoting muscle growth functions is better than embodiment 6.
Embodiment 9: it is as follows that desire processing contains raw material and processing method that the medicine for external use 8.46kg (84.6 parts, every part by 100g calculating) of effective composition chooses:
1, at first takes by weighing clean, pure Rhizoma Smilacis Glabrae 700g (7 parts), Realgar 200g (2 parts), Calomelas 200g (2 parts), Semen Hydnocarpi 400g (4 parts), Colophonium 600g (6 parts), Radix Angelicae Sinensis 450g (4.5 parts), Margarita powder 350g (3.5 parts), Natrii Sulfas 2800g (28 parts), Plumbum preparatium 500g (5 parts), Calamina 550g (4 parts), Borneolum Syntheticum 60g (0.6 part), Radix Angelicae Dahuricae 150g (1.5 parts), Rhizoma Coptidis 250g (2.5 parts), Radix Sophorae Flavescentis 250g (2.5 parts), pyrolusitum 300g (3 parts), Indigo Naturalis 200g (2 parts), sulfur 200g (2 parts), Lithargyrum 300g (3 parts).2, grind and mix: then above Chinese medicinal components is ground to form fine powder, and it is fully mixed.3, processing ointment: the ratio that is 3.5 times of effective ingredient weight at first by weight, take by weighing vaseline 29.61kg, take by weighing starch 3.4kg, then 29.61kg vaseline is put into container and heating and melting, and in it, add 8.46kg effective ingredient and 3.4kg starch, and constantly stir simultaneously, make their abundant mix homogeneously, make ointment, by every bottle of 100g-500g ointment bottling.The coating Therapeutic Method is identical with embodiment 1.Because present embodiment is compared with embodiment 8, has substituted the bigger Hydrargyri Oxydum Rubrum of toxicity with the Lithargyrum, so the protective effect of skin is better than embodiment 8.
If this medicine for external use is made liquor, then need the active component water in the present technique solution is decocted 3-5 time, each 30 minutes, filtrate is fully mixed, the content of its active component content in medicinal liquid is 10-15%.During use, medicinal liquid is spread upon the affected part get final product.
In like manner, that the technical solution that provides according to the present invention can also provide each component content is different with above embodiment, but cure the disease effect and the essentially identical embodiment of above embodiment.
Claims (10)
1, a kind of medicine for external use for the treatment of HIV (human immunodeficiency virus) (Human Immunodeficiency Virus) is characterized in that, its effective ingredient is to be made by following compositions in weight portion basically, Rhizoma Smilacis Glabrae 1.5-10 part, Realgar 1-3.5 part, Calomelas 1-3 part, Semen Hydnocarpi 1.5-5 part, Colophonium 1.5-10 part, Radix Angelicae Sinensis 1.5-5 part, Margarita powder 1.5-5 part, Natrii Sulfas 25-35 part, Plumbum preparatium or Alumen or Hydrocerussitum (Ceruse) 1.5-10 part, Calamina 1.5-10 part.
2, according to the medicine for external use of the described treatment HIV (human immunodeficiency virus) (Human Immunodeficiency Virus) of claim 1, it is characterized in that, in its effective ingredient, added Borneolum Syntheticum 0.3-1 part again, Radix Sophorae Flavescentis 1-3.5 part.
3, according to the medicine for external use of claim 1 or 2 described treatment HIV (human immunodeficiency virus) (Human Immunodeficiency Virus), it is characterized in that, in its effective ingredient, added Radix Angelicae Dahuricae 1-3.5 part again.
4, according to the medicine for external use of claim 1 or 2 described treatment HIV (human immunodeficiency virus) (Human Immunodeficiency Virus), it is characterized in that, in its effective ingredient, added Rhizoma Coptidis 1-3.5 part again.
5, according to the medicine for external use of the described treatment HIV (human immunodeficiency virus) (Human Immunodeficiency Virus) of claim 3, it is characterized in that, in its effective ingredient, added Rhizoma Coptidis 1-3.5 part again.
6, according to the medicine for external use of the described treatment HIV (human immunodeficiency virus) (Human Immunodeficiency Virus) of claim 4, it is characterized in that, in its effective ingredient, added pyrolusitum 1-3.5 part again, Indigo Naturalis 1.5-5 part.
7, according to the medicine for external use of the described treatment HIV (human immunodeficiency virus) (Human Immunodeficiency Virus) of claim 5, it is characterized in that, in its effective ingredient, added pyrolusitum 1-3.5 part again, Indigo Naturalis 1.5-5 part.
8, according to the medicine for external use of the described treatment HIV (human immunodeficiency virus) (Human Immunodeficiency Virus) of claim 6, it is characterized in that, in its effective ingredient, added sulfur 1-3.5 part again.
9, according to the medicine for external use of the described treatment HIV (human immunodeficiency virus) (Human Immunodeficiency Virus) of claim 7, it is characterized in that, in its effective ingredient, added sulfur 1-3.5 part again.
10, according to the medicine for external use of the described treatment HIV (human immunodeficiency virus) (Human Immunodeficiency Virus) of claim 9, it is characterized in that, in its effective ingredient, added Lithargyrum or Hydrargyri Oxydum Rubrum 1-3 part again.
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| CNB031391192A CN1241629C (en) | 2003-08-15 | 2003-08-15 | External medicine for treating AIDS virus |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105055877A (en) * | 2015-08-11 | 2015-11-18 | 王义朋 | Compound ointment for treating psoriasis |
| CN106389488A (en) * | 2016-12-05 | 2017-02-15 | 张广生 | Unguent for treating warm stomachache disease |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| WO2021035226A2 (en) * | 2019-07-26 | 2021-02-25 | Andrea Savarino | Methods for solubilization of arsenic sulfide minerals and their use as therapeutics |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105055877A (en) * | 2015-08-11 | 2015-11-18 | 王义朋 | Compound ointment for treating psoriasis |
| CN106389488A (en) * | 2016-12-05 | 2017-02-15 | 张广生 | Unguent for treating warm stomachache disease |
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