CN1513311A - Suspension emulsion of nicotine microcapsule, and its prepn. method - Google Patents
Suspension emulsion of nicotine microcapsule, and its prepn. method Download PDFInfo
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- CN1513311A CN1513311A CNA031391311A CN03139131A CN1513311A CN 1513311 A CN1513311 A CN 1513311A CN A031391311 A CNA031391311 A CN A031391311A CN 03139131 A CN03139131 A CN 03139131A CN 1513311 A CN1513311 A CN 1513311A
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- nicotine
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- suspension emulsion
- microcapsules
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Abstract
A nicotine microseftgel suspension for green economic crops is prepared from nicotine, surfactant, plant oil, assistant, solvent, and water through hydrolizing two or more of animal glue, plant gum and gelatin of sea products to obtain hydrated substance, proportionally mixing said raw materials, heating to 50-80 deg.C, stirring, adding the heated said hydrated substance at 50-80 deg.C after filter, stirring at 200-600 rpm, and naturally cooling. Its advantages are slow photodegradation, and high durability.
Description
(1) technical field:
The present invention relates to the formulation technical field of agricultural chemicals, is a kind of Nicotinic Microcapsule Suspending Agent And Its Preparation Method specifically.
(2) background technology:
As everyone knows, nicotine directly proposes from tobacco, has the characteristics of efficient, low toxicity, noresidue, and suitable pollution-free green food is used, but nicotine itself is seen photolysis, is evaporated completely in half an hour in the sun.
(3) summary of the invention:
Purpose of the present invention is intended to overcome the deficiency of above-mentioned prior art, and a kind of nicotine microcapsules suspension emulsion is provided.
Another object of the present invention provides the preparation method of nicotine microcapsules suspension emulsion.
The present invention has mainly solved nicotine and has seen the problem that photolysis is fast.
Nicotine microcapsules suspension emulsion of the present invention since its capsule skin forms by natural high molecular polymer fully, can be in air cracking fully, to plant itself and environmental nonpollution, can large tracts of land use on economic crops such as vegetables, melon and fruit.
In order to achieve the above object, the present invention is achieved in that nicotine microcapsules suspension emulsion, it is characterized in that it is is effective ingredient with nicotine, and contain surfactant, vegetable oil, auxiliary agent, solvent, water, also contain the composition of in animal glue, natural plant gum and the marine product glue two kinds and two or more hydrolysate simultaneously.
Nicotine microcapsules suspension emulsion of the present invention, its described surfactant are triphen ethyl phenol APEO, two Bian Ji xenol APEOs; Its described vegetable oil is cottonseed oil, rapeseed oil, castor oil acid; Described auxiliary agent is calcium dodecyl benzene sulfonate, phenethyl phenol polyethenoxy polyethenoxy ether, castor oil ethylene oxide adduct; Described solvent is a dimethylbenzene; Described animal glue is gelatin; Described natural plant gum is an amylan; Described marine product glue is fish glue, sodium alginate.
The preparation method of nicotine microcapsules suspension emulsion of the present invention comprises following processing step:
A, the making of capsule nuclear in oily liquid nicotine, adds auxiliary agent, vegetable oil, surfactant, adds solvent again and dilutes, and is heated to 50-80 ℃, constantly stirs simultaneously, adds a certain amount of water again;
B, the making of capsule skin is carried out all kinds of glue respectively earlier with two or more the glue in animal glue, natural plant gum, the marine product glue and is separated, and is heated to 50-80 ℃ respectively, filters the back and mixes, and stirring gets final product;
C, microcapsule formulation is poured the capsule skin raw material of step b in the reactor of capsule nuclear of step a, mixes under 200-600 rev/min rotating speed and stirs, and after lowering the temperature 2 hours naturally simultaneously, packs.
The preparation method of nicotine microcapsules suspension emulsion of the present invention, when its described capsule skin adopted animal glue and natural plant gum, its capsule hole skin was little and inhomogeneous, did not reach the release time of regulation on request, therefore also need add blowing agent.
Nicotine microcapsules suspension emulsion of the present invention is with organic macromolecule the effective body of agricultural chemicals to be wrapped from the outside, the lattice voids of handy big minute ascus wall discharges slowly, avoid its photodissociation, thereby reduce the consumption of former medicine greatly, prolong the lasting period, can control its lasting period and rate of release artificially; Because of nicotine sees that photolysis is fast, thereby be its effective drug duration of control, the particle diameter of its microcapsules is bigger, generally is controlled at the 10-50 micron.
A kind of Nicotinic Microcapsule Suspending Agent And Its Preparation Method of the present invention compared with the prior art, have substantive distinguishing features and marked improvement: 1, nicotine microcapsules suspension emulsion sees that photolysis is slow, thereby improve its drug effect, prolong effective drug duration simultaneously, learn through test, its former medicine reduces 30-50%, and control efficiency improves 10-20%, and the lasting period prolongs 3-10 doubly; 2, its capsule skin of nicotine microcapsules suspension emulsion is made up of natural polymer fully, and fully biodegradable, thereby noresidue can be extensive use of on the nuisanceless green economic crops.
(4) embodiment:
In order to understand better and to implement, describe a kind of Nicotinic Microcapsule Suspending Agent And Its Preparation Method of the present invention in detail below in conjunction with embodiment.
Embodiment 1, with 2.8g oily liquid nicotine, adding 0.5g calcium dodecyl benzene sulfonate, 0.5g phenethyl phenol polyethenoxy polyethenoxy ether, 3g castor oil, 4g triphen ethyl phenol APEO, 6g dimethylbenzene, be heated to 70 ℃, constantly stir simultaneously, add 16g water again, standby; 8g gelatin, 8g sodium alginate are added 92g water respectively to be hydrolyzed, be heated to 70 ℃ respectively, each 25g of glue that gets after the said hydrolyzed filters, filtering the back mixes, and stir, the glue that stirs is added in the reserve liquid of making previously, under 400 rev/mins rotating speed, mix and stir, naturally cooling promptly got nicotine microcapsules suspension emulsion after 2 hours simultaneously.
Nicotine microcapsules suspension emulsion of the foregoing description and 5% nicotine cream are at control cabbage caterpillar drug effect lasting period contrast table such as table 1.
Table 1
| The test sample | Extension rate | Borer population is counted head/strain before the medicine | Preceding 1 day of medicine | Behind the medicine 3 days | Behind the medicine 5 days | |||
| Head/strain | Proofread and correct preventive effect % | Head/strain | Proofread and correct preventive effect % | Head/strain | Proofread and correct preventive effect % | |||
| Nicotine microcapsules suspension emulsion | 1000 | ????8 | ????1 | ??87.5 | ????1.2 | ????80 | ????2.5 | ??68.75 |
| 5% nicotine cream | 1000 | ????6 | ????2 | ??66.7 | ????7 | ????0 | ????7 | ????0 |
| Control group | Not dispenser | ????5 | ????5 | ????/ | ????6 | ????/ | ????8 | ????/ |
Embodiment 2, with 5g oily liquid nicotine, adding 0.6g calcium dodecyl benzene sulfonate, 0.6g castor oil ethylene oxide adduct, 4g cottonseed oil, 4.5g two Bian Ji xenol APEOs, 7g dimethylbenzene, be heated to 60 ℃, constantly stir simultaneously, add 18g water again, standby; 8g amylan, 8g sodium alginate are added 92g water respectively to be hydrolyzed, be heated to 60 ℃ respectively, each 28g of glue that gets after the said hydrolyzed filters, filtering the back mixes, and stir, the glue that stirs is added in the reserve liquid of making previously, under 500 rev/mins rotating speed, mix and stir, naturally cooling promptly got nicotine microcapsules suspension emulsion after 2 hours simultaneously.
Embodiment 3, with 2g oily liquid nicotine, adding 0.2g calcium dodecyl benzene sulfonate, 0.2g phenethyl phenol polyethenoxy polyethenoxy ether, 2g rapeseed oil, 3g triphen ethyl phenol APEO, 5g dimethylbenzene, be heated to 50 ℃, constantly stir simultaneously, add 14g water again, standby; 7.5g gelatin, 7.5g amylan are added 92g water respectively to be hydrolyzed, be heated to 50 ℃ respectively, each 15g of glue that gets after the said hydrolyzed filters, filter the back and mix, and stir, add the 1g blowing agent, the glue that stirs is added in the reserve liquid of making previously, mix under 200 rev/mins rotating speed and stir, cooling promptly got nicotine microcapsules suspension emulsion after 2 hours naturally simultaneously.
Embodiment 4, with 10g oily liquid nicotine, adding 1g calcium dodecyl benzene sulfonate, 1g phenethyl phenol polyethenoxy polyethenoxy ether, 5g castor oil, 5g triphen ethyl phenol APEO, 10g dimethylbenzene, be heated to 80 ℃, constantly stir simultaneously, add 20g water again, standby; 8g gelatin, 8g sodium alginate are added 92g water respectively to be hydrolyzed, be heated to 60 ℃ respectively, each 30g of glue that gets after the said hydrolyzed filters, filter the back and mix, and stir, the glue that stirs is added in the reserve liquid of making previously, under 600 rev/mins rotating speed, mix and stir, naturally cooling was packed behind adding anti-icing fluid, the dyestuff after 2 hours simultaneously, promptly got nicotine microcapsules suspension emulsion.
Claims (4)
1, nicotine microcapsules suspension emulsion, it is characterized in that it is is effective ingredient with nicotine, and contain surfactant, vegetable oil, auxiliary agent, solvent, water, also contain the composition of in animal glue, natural plant gum and the marine product glue two kinds and two or more hydrolysate simultaneously.
2, by the described nicotine microcapsules of claim 1 suspension emulsion, it is characterized in that described surfactant is triphen ethyl phenol APEO, two Bian Ji xenol APEOs; Vegetable oil is cottonseed oil, rapeseed oil, castor oil acid; Auxiliary agent is calcium dodecyl benzene sulfonate, phenethyl phenol polyethenoxy polyethenoxy ether, castor oil ethylene oxide adduct; Solvent is a dimethylbenzene; Animal glue is gelatin; Natural plant gum is an amylan; Marine product glue is fish glue, sodium alginate.
3, the preparation method of the described nicotine microcapsules of claim 1 suspension emulsion comprises following processing step:
A, the making of capsule nuclear in oily liquid nicotine, adds auxiliary agent, vegetable oil, surfactant, adds solvent again and dilutes, and is heated to 50-80 ℃, constantly stirs simultaneously, adds a certain amount of water again;
B, the making of capsule skin is carried out all kinds of glue respectively earlier with two or more the glue in animal glue, natural plant gum, the marine product glue and is separated, and is heated to 50-80 ℃ respectively, filters the back and mixes, and stirring gets final product;
C, microcapsule formulation is poured the capsule skin raw material of step b in the reactor of capsule nuclear of step a, mixes under 200-600 rev/min rotating speed and stirs, and after lowering the temperature 2 hours naturally simultaneously, packs.
4, by the preparation method of the described nicotine microcapsules of claim 3 suspension emulsion, it is characterized in that described capsule skin manufacturing process steps adopts the hydrolysate of animal glue and natural plant gum to mix after, add blowing agent.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 03139131 CN1229020C (en) | 2003-08-16 | 2003-08-16 | Suspension emulsion of nicotine microcapsule, and its prepn. method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 03139131 CN1229020C (en) | 2003-08-16 | 2003-08-16 | Suspension emulsion of nicotine microcapsule, and its prepn. method |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1513311A true CN1513311A (en) | 2004-07-21 |
| CN1229020C CN1229020C (en) | 2005-11-30 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 03139131 Expired - Fee Related CN1229020C (en) | 2003-08-16 | 2003-08-16 | Suspension emulsion of nicotine microcapsule, and its prepn. method |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101330826B (en) * | 2005-12-14 | 2012-08-22 | 住友化学株式会社 | Microcapsule containing solid agrochemical active compound |
| CN103651588A (en) * | 2013-09-10 | 2014-03-26 | 北京联合大学生物化学工程学院 | Preparation method for microcapsule pesticide for killing aphids |
| CN109757475A (en) * | 2019-03-01 | 2019-05-17 | 杨卫东 | A kind of microcapsule formulation and preparation method thereof coating solid pesticide raw medicine |
| CN110250174A (en) * | 2018-03-12 | 2019-09-20 | 山东侨昌现代农业有限公司 | A kind of oil-containing dry suspending agent dosage form and processing technology |
-
2003
- 2003-08-16 CN CN 03139131 patent/CN1229020C/en not_active Expired - Fee Related
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101330826B (en) * | 2005-12-14 | 2012-08-22 | 住友化学株式会社 | Microcapsule containing solid agrochemical active compound |
| CN103651588A (en) * | 2013-09-10 | 2014-03-26 | 北京联合大学生物化学工程学院 | Preparation method for microcapsule pesticide for killing aphids |
| CN103651588B (en) * | 2013-09-10 | 2015-11-11 | 北京联合大学生物化学工程学院 | A kind of preparation method of the encapsulate pesticides for killing aphid |
| CN110250174A (en) * | 2018-03-12 | 2019-09-20 | 山东侨昌现代农业有限公司 | A kind of oil-containing dry suspending agent dosage form and processing technology |
| CN109757475A (en) * | 2019-03-01 | 2019-05-17 | 杨卫东 | A kind of microcapsule formulation and preparation method thereof coating solid pesticide raw medicine |
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| Publication number | Publication date |
|---|---|
| CN1229020C (en) | 2005-11-30 |
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| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| ASS | Succession or assignment of patent right |
Owner name: ZHONG WEIDE Free format text: FORMER OWNER: ZHANG TIANLIANG Effective date: 20061013 |
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| C41 | Transfer of patent application or patent right or utility model | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20061013 Address after: 100071, Fengtai District Science City, Beijing, No. 10 Spark Road B-107 Beijing Tianshan dark horse Biotechnology Co., Ltd. Patentee after: Zhong Weide Address before: 265601 north ditch, Shandong, Penglai, Beijing, Shandong, Beijing biological pharmaceutical, Limited by Share Ltd Patentee before: Zhang Tianliang |
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| EE01 | Entry into force of recordation of patent licensing contract |
Assignee: Beijing Tianshan dark horse Biotechnology Co., Ltd. Assignor: Zhong Weide Contract fulfillment period: 2007.6.6 to 2012.6.5 contract change Contract record no.: 2009990000430 Denomination of invention: Suspension emulsion of nicotine microcapsule, and its prepn. method Granted publication date: 20051130 License type: Exclusive license Record date: 2009.5.6 |
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| LIC | Patent licence contract for exploitation submitted for record |
Free format text: EXCLUSIVE LICENSE; TIME LIMIT OF IMPLEMENTING CONTACT: 2007.6.6 TO 2012.6.5; CHANGE OF CONTRACT Name of requester: BEIJING TIANSHAN HEIMA BIOTECHNOLOGY CO., LTD. Effective date: 20090506 |
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| C17 | Cessation of patent right | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20051130 Termination date: 20120816 |