CN1507456A - Fibre containing composition for enteral nutrition - Google Patents
Fibre containing composition for enteral nutrition Download PDFInfo
- Publication number
- CN1507456A CN1507456A CNA028093488A CN02809348A CN1507456A CN 1507456 A CN1507456 A CN 1507456A CN A028093488 A CNA028093488 A CN A028093488A CN 02809348 A CN02809348 A CN 02809348A CN 1507456 A CN1507456 A CN 1507456A
- Authority
- CN
- China
- Prior art keywords
- maltodextrin
- enriched
- nutritional composition
- fiber
- enteral nutritional
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
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- 229920002774 Maltodextrin Polymers 0.000 claims abstract description 48
- 235000000346 sugar Nutrition 0.000 claims abstract description 7
- 239000005913 Maltodextrin Substances 0.000 claims description 44
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- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
- A23L2/02—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation containing fruit or vegetable juices
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
- A23L2/52—Adding ingredients
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
- A23L29/30—Foods or foodstuffs containing additives; Preparation or treatment thereof containing carbohydrate syrups; containing sugars; containing sugar alcohols, e.g. xylitol; containing starch hydrolysates, e.g. dextrin
- A23L29/35—Degradation products of starch, e.g. hydrolysates, dextrins; Enzymatically modified starches
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/20—Reducing nutritive value; Dietetic products with reduced nutritive value
- A23L33/21—Addition of substantially indigestible substances, e.g. dietary fibres
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/40—Complete food formulations for specific consumer groups or specific purposes, e.g. infant formula
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B30/00—Preparation of starch, degraded or non-chemically modified starch, amylose, or amylopectin
- C08B30/12—Degraded, destructured or non-chemically modified starch, e.g. mechanically, enzymatically or by irradiation; Bleaching of starch
- C08B30/18—Dextrin, e.g. yellow canari, white dextrin, amylodextrin or maltodextrin; Methods of depolymerisation, e.g. by irradiation or mechanically
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
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- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Polymers & Plastics (AREA)
- Food Science & Technology (AREA)
- Nutrition Science (AREA)
- Mycology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Pediatric Medicine (AREA)
- Crystallography & Structural Chemistry (AREA)
- Materials Engineering (AREA)
- Biochemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Non-Alcoholic Beverages (AREA)
Abstract
The invention concerns a composition for enteral nutrition enriched in fibres characterised in that it comprises 0.5 to 20 %, preferably 1 to 10 % and more preferably still 1 to 5 % by dry weight of branched maltodextrins having between 15 and 35 % of 1-6 glucoside linkages, a reducing sugar content less than 20 %, a polymolecularity of less than 5 and a number-average molecular weight (Mn) not more than 4500 g/mol.
Description
The present invention relates to contain the intestinal nutrient composition of fiber.
More precisely, the objective of the invention is to contain the intestinal nutrient composition of branch's maltodextrin.
Artificial nutrient substance makes grownup and children can compensate the enteron aisle defective, alleviates enteritis, corrects serious malnutrition in the patient that can't take food because of serious illness or because of the treatment of trouble or be reluctant to take food.Its process can be from a few days to several weeks to some months or several years.According to circumstances, artificial nutrient substance can play a role by digestion approach (intestinal nutrient) or by intravenous route (non-enteric nutrient).Past usually needs to be in hospital, give and need to strengthen nursing in the mode of internal medicine, surgery, when needs very during long periods of treatment artificial nutrient substance can continue at home now.The fundamental principle of intestines or the artificial nutrient substance of non-enteron aisle is to satisfy the required whole nutrient substances of life: sugar, fat, protein, mineral substance, trace element, VITAMIN, these materials are that the patient no longer can be by conventional oral cavity route picked-up.
Intestinal nutrient be nutrition subsidy the most simply and meet physiological approach most.Fail and pass the position normally in stomach, need help by the flexible pipe of nose approach introducing.Effective and well tolerable intestinal nutrient comprises two basic engineering philosophies: low speed (1-3ml/min) and the continuous food that instils (12 hours-24 hours every day).
If the damage of the enteron aisle degree of depth loses absorptive function, then used food is through predigested (amino acid, monose).
When small intestine still has function, can use half basal diet (semi-basic diet) that contains the lower even undigested nutrient substance of digestible degree.Mineral substance, trace element and VITAMIN are to add system and every day.When industrial preparation, nutrition be very clean or even aseptic condition under preparation, mix and storage.
Inpatient and especially accept antibiotic therapy or suffer from the patient of the bowel dysfunction that causes constipation or diarrhoea,, and need accept nutritional supplementation by the enteron aisle approach, need to replenish suitable fiber.
It is useful and should constitute the essential part that daily food replenishes to human health that fiber is considered to.Fiber is divided into two kinds usually: soluble fiber and insoluble fibre.Soluble fiber is fermented by intestinal flora as pectin, inulin, weather resistance starch (resistant starch).This fermentation discharges the lipid acid of short chain in colon, this has the effect that reduces its pH, and can limit the growth of pathogenic bacterium.
Insoluble fibre has important mechanical effect as Mierocrystalline cellulose, corn or soybean fibers in gi tract.They are only slightly fermented by intestinal flora, help to reduce the time that rests in the enteron aisle.
The composition that ideal is used for the fiber-enriched of intestines nutrition should satisfy:
-with usually edible fiber-like seemingly;
-can produce useful voltaile fatty acid;
-can in the patient, not cause flatulence;
-improve intestines peristalsis;
-there is not a residue;
-solvable;
-suitable viscosity is arranged to be easy to its instillation;
-when storing and sterilize, be stable;
-absorbed gradually;
-promote mineral substance to absorb.
The intestinal nutrient composition that some contain fiber has been proposed.Advised that the pectin fiber is proposed, but that it has is too high and can't promote the shortcoming that mineral substance absorbs such as viscosity.
Patent EP-R1 0,756, and 828 have described the composition of fiber-enriched, and it contains the mixture of soluble fiber, insoluble fibre and weather resistance starch.These compositions contain a high proportion of soluble fiber and higher viscosity are arranged, and this is not suitable for instiling by flexible pipe.These compositions also have stability problem.
File EP-A1 1,010,374 has described the fibre blend that contains solubility and insoluble pea fiber, inulin and Nutriflora P that is used for intestines nutrition.These compositions are still too sticking, especially when having sl. sol. pea fiber and inulin; Nutriflora P is unsettled when sterilization.This unstable has caused hydrolysis gradually, and this makes the release of glucose and fructose and pigment, and all these is unwanted.These fibre blends only part promote the absorption of mineral substance, and do not absorb gradually.In addition, pea fiber and inulin have produced the problem of flatulence in the patient.As for Nutriflora P, these molecules still are the low tolerances of body, and this shows as the generation of diarrhoea.
Therefore, the objective of the invention is to solve the shortcoming of prior art.The applicant finds, adding described branch maltodextrin at the composition that is used for intestines nutrition can make it satisfy these all purposes, these purposes all are considered to solve by design and manufacturing up to now, through big quantity research, developed a kind of composition that is used for the novel fiber-enriched of intestines nutrition, it can satisfy all above-mentioned standards, be the stability in viscosity, solvability, storage and the sterilization process, show as and do not had degeneration, can digest gradually, can not produce flatulence and promote well the especially absorption of calcium and magnesium of mineral substance.
Therefore, the objective of the invention is the enteral nutritional composition of fiber-enriched, it is characterized in that, the side chain maltodextrin that described composition contains contains the 15-35%1-6 glucoside chain, content is lower than 20% reducing sugar, and polymolecularity is less than 5, and number-average molecular weight Mn is no more than 4500g/mol.
With regard to the object of the invention, term side chain maltodextrin is meant the Star Dri 5 of describing among the patent application EP 1,006,128 (the applicant is its owner).These side chain maltodextrins have heavy characteristics, and consequently their absorptions in small intestine are hindered, thereby caloric value is reduced.Therefore, they have represented the source to the favourable heavy fiber of metabolism and intestines inner equilibrium.Generally speaking, based on dry-matter, its insoluble fibre level is usually greater than 50%.Its high 1 → 6 glycosidic link content makes them have very unique preceding biology (prebiotic) characteristic: this is actually clearly, because the bacterium in humans and animals caecum and the colon, as butyric bacteria (butyrogenic), milk-acid bacteria or bacterium acidi propionici, the compound that metabolism is hyperbranched.In addition, thus these ramose maltodextrins can promote the growth of bifidus bacillus to suppress unwanted bacterium.This just makes their healthy highly beneficial to the human consumer.At last, branch's characteristic of described maltodextrin has reduced the characteristic that they are brought back to life to a great extent and advantageously, and this makes the situation about need not bring back to life of they can being used for, especially when the medium-term and long-term storage of aqueous solution.
Patent application EP 1,006, all the branch's maltodextrin compositions described in 128 all are fit to be used for preparing the composition that is used for intestines nutrition of the present invention.
According to preferred variation, its reducing sugar content is between 2-5%, and number-average molecular weight is between 2000-3000g/mol.
According to another favourable variation, these ramose maltodextrins are by all or part of hydrogenation, and therefore advantageously they are more stable when sterilization.
The enteral nutritional composition of fiber-enriched contains dry weight and accounts for 0.5-20%, preferred 1-10%, more preferably branch's maltodextrin of 1-5% dry weight as described in the present invention, to replenish and enough energy supplements as fiber.With dry weight basis, described ramose maltodextrin contains and surpasses 50% insoluble fibre, and this is to measure according to the method for AOAC No.985-29 (1986).As described in the present invention in the enteral nutritional composition maltodextrin weigh less than 0.5%, then this fiber undersupply is to have detectable effect.
Demonstrated the remarkable improvement that calcium and magnesium absorb in animal especially, this has caused the remarkable result with other illustration, and this makes us can make the composition for intestines nutrition, this composition for improved patient's calcium and magnesium situation.This composition that known absorption to mineral substance is had the fiber-enriched of negative effect is wondrous and unforeseen.
In addition, can not produce osmotic diarrhea even if also find ramose maltodextrin of the present invention at high dosage yet.But when absorbing lower molecular weight fermentable carbohydrates such as lactulose or Nutriflora P, can be observed the osmotic diarrhea phenomenon.This phenomenon causes water-content increase in the stool as the reflection that ight soil inclusion osmotic pressure increases, and the increase of this water-content finally can cause diarrhoea to take place.Curiously, and what never expect is that branch of the present invention maltodextrin can not produce this phenomenon, although they are fermentable.
Enteral nutritional composition also contains protein, lipid and carbohydrate as described in the present invention.Preferably, protein accounts for the 10-20% that this composition energy is supplied with.For example, they are that protein by animal protein such as dairy protein or soy-protein or cereal source provides.They can be natural or hydrolysed form provide, so that total free aminoacids to be provided.
Described lipid preferably provides the energy of said composition 30-50% to supply with, with the form of single unsaturated, how unsaturated and saturated fatty acid.In fact any oil all is suitable, for example sweet oil, Semen Maydis oil, sunflower seed oil, little wheat oil and raisin seed oil.
Except that described ramose maltodextrin, the 35-55% that carbohydrate preferably provides energy to supply with.They can standard starch or through the starch of modification, high amylose starch, provide through the form of maltodextrin modification or standard, simple sugar.Ramose maltodextrin of the present invention can provide energy to supply with certainly simultaneously and Mierocrystalline cellulose is supplied with.
Enteral nutritional composition can contain also that VITAMIN and mineral substance are replenished completely as described in the present invention.Also can add spices, sweeting agent and other additive.
Although be not that the present invention preferably changes, described branch maltodextrin also can be by the dextrin of indigestibility, such as, the FIBERSOL that makes of MATSUTANI especially
, substitute wholly or in part.Yet because the latter's insoluble fibre content is lower, they mix with described branch maltodextrin is favourable.
Therefore, enteral nutritional composition can contain and heavy dextrin blended ramose maltodextrin as described in the present invention.
Described composition can finished product (ready-to-use) form provide, being the form that can inculcate by stomach tube, perhaps with the form of beverage such as fruit juice, soup or milk shake, perhaps can be the form of dessert cream or sour milk, it can directly supply edible for patients, perhaps uses by flexible pipe.
The powder type that described composition can be rebuild in liquid provides.
The ramose maltodextrin has stability in acidic medium as described in the present invention, and thermal treatment is had stability, and this is very favorable when needs are made into subacidity to the enteral nutritional composition of acid pH such as beverage, soup or fruit juice.Nutriflora P is not observed this stability.In addition, when composition that preparation need be sterilized, usually preferred these compositions be weakly acidic when avoiding thermal treatment the carbohydrate caramelize.Therefore, described branch maltodextrin in acidic medium stability and/or the stability of heat is very favorable and is suitable.
No matter be solid or liquid, described enteral nutritional composition is preferably sterilized with known to the skilled any technology of being proficient in this field, if necessary, and is packaged in box, sack or the aseptic bottle.
In fact, the available any routine techniques of preparation liquid or solid-state enteral nutritional composition carries out, and for example comprises simply various powder compositions are mixed, and perhaps will contain the solution spray drying of all described compositions.When the needs liquid form, described composition should be easily by flexible pipe or only use by gravity or by pump.It should have lower viscosity, for example at room temperature less than 40mPa.s.
Described enteral nutritional composition can be used for animal.
Followingly will be expressly understood the present invention more by reading to exemplify the embodiment and the relevant drawings that provide with unrestricted purpose.
Embodiment 1: the checking that mineral substance absorbs
With contain the 5-10% dry weight as described herein the standard food of branch's maltodextrin raise one group of rat.Control group is only accepted standard food.
Group 1 is accepted standard food.Group 2 accepts to be mixed with the food of 5% branch's maltodextrin, and group 3 accepts to be mixed with the food of 10% branch's maltodextrin.Experiment has been carried out 14 days, carries out the evaluation of calcium and magnesium by calcium and the magnesium of analyzing stool, distribute in the food and drinking water of animal at last.
Obtained following result:
| Calcium | Magnesium | |||
| Intestinal absorption * (%) | Variation (%) with respect to group 1 | Intestinal absorption (%) | Variation (%) with respect to group 1 | |
| Group 1 | ??21.52 | ????- | ????32.74 | ????- |
| Group 2 | ??29.62 | ????+37.6 | ????39.34 | ????+20.2 |
| Group 3 | ??38.49 | ????+78.9 | ????47.8 | ????+46.0 |
* intestinal absorption is to calculate by deduct in the stool leveler of identical mineral substance from the mineral level of food and drinking-water, represents with percentage ratio.
These results have clearly demonstrated provides the ramose maltodextrin that mineral substance is absorbed with very favorable influence in the diet of rat in digestive tube, this point is very strange for high compound, because known these compounds have undesirable action for the absorption of mineral substance.
Embodiment 2: prepare enteral nutritional composition of the present invention
Made enteral nutritional composition by branch's maltodextrin of forming below in distilled water, mixing:
| Reducing sugar | ????2.3 |
| ????Mn(g/mol) | ????2480 |
| ????Mw(g/mol) | ????5160 |
| 1,2 key (%) | ????10 |
| 1,3 key (%) | ????12 |
| 1,4 key (%) | ????49 |
| 1,6 key (%) | ????29 |
The mixture that in this solution, adds Semen Maydis oil, rapeseed oil and soybean oil, dairy protein and soy proteinaceous mixture, standard maltodextrin and VITAMIN and mineral substance.
Thus obtained composition is described below (weight %):
-protein: 4%
-carbohydrate: 11
-lipid: 4%
-branch maltodextrin: 3%
-insoluble fibre: 1.5%
The composition that obtains was stored six months, estimate the stability in the storage process then: composition is uniformly and does not have crystal or precipitation, this explanation is not brought back to life, and therefore explanation has satisfactory stability when storing, and this makes composition of the present invention that validity period more than six months be arranged.
Embodiment 3: the Study on Stability in the solution
For understanding the stability of described branch maltodextrin in beverage, prepared the solution of different pH values, contain Nutriflora P (the RAFTILOSE P35 that ACTILIGHT 950P that BEGHIN-SAY sells or ORAFTI sell) or branch of the present invention maltodextrin.
In storage process, detect the molecular weight of measuring these oligosaccharides in the solution by steric exclusion and differential refraction.
The results are shown among Fig. 1.
If branch's maltodextrin has been observed very slight solution acidizing effect.Therefore in very following slight hydrolysis of tart pH value (less than 3), this causes molecular weight to change to lower value.After storing for two weeks, this variation is not more than observed immediately variation after acidifying.Store after one month, only low-down pH value (less than 2.7) down observed value be reduced to slaking corresponding to two weeks.The number-average molecular weight that pH equals 2 solution changes to 2400 dalton from 2800 dalton.
If Nutriflora P, after pH2 stored for two weeks, its initial value of molecular weight ratio had reduced by 30%.After 1 month, the solution of pH2 and pH2.7 contains the Nutriflora P of very high degraded.
Conclusion: the ramose maltodextrin is well suited for preparation pH usually less than 3 beverage, fruit juice or vegetables juice.
Embodiment 4: to heat treated stability
Prepared the fruit juice that contains branch of the present invention maltodextrin, it has been carried out 17 minutes sterilising treatment at 74 ℃.Contrast that does not have branch's maltodextrin and the contrast that contains Nutriflora P have also been prepared.Compare content before and after handling and after storing.The pH of all fruit juice is 3.8.
The result gives in following table:
| Contrast | 7% branch's maltodextrin | 7% hydrogenant branch maltodextrin | 7% Nutriflora P (ACTILIGHT ) | ||||
| Sucrose | Sucrose | Branch's maltodextrin | Sucrose | Hydrogenant branch maltodextrin | Sucrose | ????FOS ? | |
| Before the sterilization | ??2.5 | ??2.4 | ????7.0 | ??2.1 | ????6.8 | ????2.3 | ????6.7 |
| After the sterilization | ??1.4 | ??1.6 | ????7.0 | ??1.6 | ????6.8 | ????2.4 | ????4.5 |
| Sterilize after+1.5 months | ??nd ? | ??nd ? | ????6.9 ? | ??nd ? | ????6.9 ? | ????3.8 ? | ????2.4 ? |
| Sterilize after+3 months | ??1.5 ? | ??1.5 ? | ????7.1 ? | ??1.2 ? | ????7.1 ? | ????3.4 ? | ????1.7 ? |
These presentation of results, no matter whether hydrogenation, branch of the present invention maltodextrin is not degraded, because they are in thermal treatment or store in 3 months the process and be not hydrolyzed.Nutriflora P is in sterilization (30%) and store (with sterilize after value compare after 3 months, reduced 60%) highly degraded.This can observe by the reduction of FOS level and the rising of sucrose (hydrolysate) content.This is the most special advantage of maltodextrin in the enteral nutritional composition as described in the present invention, especially when sterilization or sterilization.
Claims (9)
1. the enteral nutritional composition of fiber-enriched, it is characterized in that, described composition contains 0.5-20%, be preferably 1-10%, the side chain maltodextrin of 1-5% dry weight more preferably, described Star Dri 5 contains 15-35%1 → 6 glucoside chains, and content is lower than 20% reducing sugar, polymolecularity is less than 5, and number-average molecular weight Mn is no more than 4500g/mol.
2. the enteral nutritional composition of fiber-enriched as claimed in claim 1 is characterized in that, the reducing sugar content of described branch maltodextrin between 2-5%, number-average molecular weight Mn 2000 and 3000g/mol between.
3. as the enteral nutritional composition of each described fiber-enriched in claim 1 or 2, it is characterized in that described branch maltodextrin is by all or part of hydrogenation.
4. as the enteral nutritional composition of each described fiber-enriched among the claim 1-3, it is characterized in that it also contains protein and/or lipid and/or carbohydrate, VITAMIN and mineral substance.
5. as the enteral nutritional composition of each described fiber-enriched among the claim 1-4, it is characterized in that it is the powder that is used to rebuild solution.
6. as the enteral nutritional composition of each described fiber-enriched among the claim 1-4, it is characterized in that it is ready-made available composition.
7. as the enteral nutritional composition of each described fiber-enriched among the claim 1-6, it is characterized in that, the insoluble fibre level of described branch maltodextrin based on dry-matter greater than 50%.
8. as the enteral nutritional composition of each described fiber-enriched among the claim 1-7, it is characterized in that described branch maltodextrin mixes with heavy dextrin.
9. as the enteral nutritional composition of each described fiber-enriched among the claim 1-8, it is characterized in that described branch maltodextrin is stablized under acidic conditions and/or to heat treated.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR01/04413 | 2001-03-30 | ||
| FR0104413A FR2822645B1 (en) | 2001-03-30 | 2001-03-30 | COMPOSITION FOR ENTERAL NUTRITION COMPRISING FIBERS |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1507456A true CN1507456A (en) | 2004-06-23 |
| CN1249091C CN1249091C (en) | 2006-04-05 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB028093488A Expired - Fee Related CN1249091C (en) | 2001-03-30 | 2002-03-26 | Fibre containing composition for enteral nutrition |
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|---|---|
| US (1) | US6737414B2 (en) |
| EP (1) | EP1245580B1 (en) |
| JP (2) | JP2004524366A (en) |
| KR (1) | KR100859224B1 (en) |
| CN (1) | CN1249091C (en) |
| AU (1) | AU2002253265B2 (en) |
| CA (1) | CA2379210C (en) |
| DE (1) | DE60217431T2 (en) |
| FR (1) | FR2822645B1 (en) |
| MX (1) | MXPA03008911A (en) |
| WO (1) | WO2002079262A1 (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102088867A (en) * | 2008-07-18 | 2011-06-08 | 罗盖特公司 | Composition of soluble indigestible fibre and of microalgae used in the well-being field |
| CN102698101A (en) * | 2012-05-25 | 2012-10-03 | 广东省农业科学院农业生物技术研究所 | Nasal feeding nutritional meal with excellent pipeline fluidity |
| CN103504293A (en) * | 2012-06-27 | 2014-01-15 | 日油株式会社 | Liquid nutrition composition |
| CN106998783A (en) * | 2014-12-26 | 2017-08-01 | 三得利控股株式会社 | Dietary fiber |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2884422B1 (en) * | 2005-04-18 | 2008-04-11 | Roquette Freres | ANTI-INFLAMMATORY COMPOSITION OF INTESTINES COMPRISING BRANCHED MALTODEXTRINS |
| JP5349744B2 (en) * | 2005-12-19 | 2013-11-20 | 松谷化学工業株式会社 | Mineral absorption promoter, food and feed |
| FR3022738B1 (en) * | 2014-06-30 | 2019-02-08 | Roquette Freres | NEW CONFECTIONERY WITHOUT FAT |
| FR3077959B1 (en) | 2018-02-22 | 2021-09-24 | Roquette Freres | PROCESS FOR MANUFACTURING RESISTANT PEA DEXTRIN |
| FR3133994A1 (en) * | 2022-03-30 | 2023-10-06 | Roquette Freres | Non-therapeutic use of hyperbranched dextrins as a soothing agent. |
| WO2023193956A1 (en) * | 2022-04-05 | 2023-10-12 | Roquette Freres | Hydrogenated hyperbranched dextrins for preserving the eubiosis of skin microbiota and microbiota of mucous membranes |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3135849A1 (en) * | 1981-09-10 | 1983-03-17 | Dr. Schumacher GmbH & Co KG, 4600 Dortmund | COATING MATERIAL FOR CORROSION PROTECTION PURPOSES |
| EP0100612A3 (en) * | 1982-07-29 | 1985-01-23 | Hilvenna Limited | Improvements in or relating to compressed gas powered ammunition for small arms |
| JPS5928725A (en) * | 1982-08-09 | 1984-02-15 | Hitachi Ltd | Logical system |
| JP2750467B2 (en) * | 1990-06-14 | 1998-05-13 | 不二製油株式会社 | Peptide mixture and enteral nutrition composition |
| JP2944008B2 (en) * | 1990-09-20 | 1999-08-30 | 森永乳業株式会社 | Parenteral lipid metabolism improver |
| GB9315385D0 (en) * | 1993-07-24 | 1993-09-08 | Ams Limited | A maltodextrin composition |
| FR2716199B1 (en) * | 1994-02-15 | 1996-04-26 | Roquette Freres | Process for the manufacture of a starch hydrolyzate with a low polymolecularity index, a new starch hydrolyzate thus obtained and its use in peritoneal dialysis. |
| US5952314A (en) * | 1994-04-01 | 1999-09-14 | Demichele; Stephen Joseph | Nutritional product for a person having ulcerative colitis |
| DE69506095T2 (en) | 1995-08-04 | 1999-06-24 | Naamloze Vennootschap Nutricia, Zoetermeer | Dietary composition containing dietary fibers |
| FR2786775B1 (en) * | 1998-12-04 | 2001-02-16 | Roquette Freres | BRANCHED MALTODEXTRINS AND THEIR PREPARATION PROCESS |
| EP1010374B2 (en) | 1998-12-15 | 2009-07-29 | Societe Des Produits Nestle S.A. | Fibre blend for enteral composition |
| AUPQ132599A0 (en) * | 1999-07-01 | 1999-07-22 | Commonwealth Scientific And Industrial Research Organisation | Nasogastric enteral formulations |
-
2001
- 2001-03-30 FR FR0104413A patent/FR2822645B1/en not_active Expired - Fee Related
-
2002
- 2002-03-26 AU AU2002253265A patent/AU2002253265B2/en not_active Ceased
- 2002-03-26 KR KR1020037012836A patent/KR100859224B1/en not_active IP Right Cessation
- 2002-03-26 WO PCT/FR2002/001038 patent/WO2002079262A1/en active IP Right Grant
- 2002-03-26 JP JP2002577885A patent/JP2004524366A/en not_active Withdrawn
- 2002-03-26 EP EP02290751A patent/EP1245580B1/en not_active Expired - Lifetime
- 2002-03-26 DE DE60217431T patent/DE60217431T2/en not_active Expired - Lifetime
- 2002-03-26 MX MXPA03008911A patent/MXPA03008911A/en active IP Right Grant
- 2002-03-26 CN CNB028093488A patent/CN1249091C/en not_active Expired - Fee Related
- 2002-03-28 CA CA2379210A patent/CA2379210C/en not_active Expired - Fee Related
- 2002-03-29 US US10/113,470 patent/US6737414B2/en not_active Expired - Fee Related
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102088867A (en) * | 2008-07-18 | 2011-06-08 | 罗盖特公司 | Composition of soluble indigestible fibre and of microalgae used in the well-being field |
| CN102098929A (en) * | 2008-07-18 | 2011-06-15 | 罗盖特公司 | Composition of soluble indigestible fibre and of eukaryotic organisms with a polysaccharide wall, used in the well-being field |
| CN102098929B (en) * | 2008-07-18 | 2017-07-11 | 罗盖特公司 | The solvable indigestibility fiber used in health field and the Eukaryotic composition with polysaccharide wall |
| CN102698101A (en) * | 2012-05-25 | 2012-10-03 | 广东省农业科学院农业生物技术研究所 | Nasal feeding nutritional meal with excellent pipeline fluidity |
| CN103504293A (en) * | 2012-06-27 | 2014-01-15 | 日油株式会社 | Liquid nutrition composition |
| CN106998783A (en) * | 2014-12-26 | 2017-08-01 | 三得利控股株式会社 | Dietary fiber |
| CN106998783B (en) * | 2014-12-26 | 2021-07-06 | 三得利控股株式会社 | Dietary fiber |
Also Published As
| Publication number | Publication date |
|---|---|
| CA2379210A1 (en) | 2002-09-30 |
| CN1249091C (en) | 2006-04-05 |
| DE60217431T2 (en) | 2007-10-25 |
| EP1245580B1 (en) | 2007-01-10 |
| WO2002079262A1 (en) | 2002-10-10 |
| MXPA03008911A (en) | 2004-06-30 |
| CA2379210C (en) | 2010-06-08 |
| KR100859224B1 (en) | 2008-09-18 |
| US20030039740A1 (en) | 2003-02-27 |
| DE60217431D1 (en) | 2007-02-22 |
| US6737414B2 (en) | 2004-05-18 |
| EP1245580A1 (en) | 2002-10-02 |
| KR20030088053A (en) | 2003-11-15 |
| AU2002253265B2 (en) | 2007-04-26 |
| FR2822645A1 (en) | 2002-10-04 |
| JP2010138183A (en) | 2010-06-24 |
| JP2004524366A (en) | 2004-08-12 |
| FR2822645B1 (en) | 2005-03-11 |
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