CN1491691A - Recipe composition of cold-resisting Chinese medicine sugar-less granular powder and tablet and preparing process - Google Patents
Recipe composition of cold-resisting Chinese medicine sugar-less granular powder and tablet and preparing process Download PDFInfo
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Abstract
The present invention relates to the recipe and preparing process of cold-resisting sugar-less Chinese medicine granule and tablet. The recipe consists of bupleurum root, skullcap root, schizonepeta ear, Yin nourishing component, and cold-expelling component. The preparation process includes decoction and filtering of skullcap root pieces to obtain filtrate; distillation of bupleurum root, schizonepeta spike and Yin nourishing component to obtain volatile oil, and decoction of the dregs; merging decoction, decompression concentration, alcohol precipitation, filtering, and mixing with skullcap root fluid extract; further concentration, adding soluble cyclodextrin, boiling, spray drying to obtain powder; coating the volatile oil with cyclodextrin to obtain inclusion; mixing the medicine powder, the inclusion and supplementary material and preparing the mixture into granule or tablet, which has certain antiseptic, antiviral, anti-inflammation, pain-relieving and heat clearing away effects.
Description
Technical field
The prescription that the present invention relates to a kind of anti-flu Chinese medicine sugar free granule, tablet is formed (comprising consumption) and preparation technology.
Technical background
As everyone knows, flu is commonly encountered diseases and frequently-occurring disease, and throughout the year, men and women, old and young all can catch an illness, and as can not in time controlling epidemic situation, involves All Around The World sometimes, and the part patient can concurrent viral pneumonia, disease such as viral myocarditis, even can cause death.Because the very easily variability of cold virus adds that most antibiotic are inoperative to cold virus, so comparatively speaking, flu is again a kind of difficult disease.At present, there is 15,000,000,000 yuan sales volume in domestic coldrex market every year, and along with the Coritab that contains phenylpropanolamine (PPA) is disabled, the Coritab of other type mostly contains compositions such as chlorphenamine again, waits side effect obviously to be out of favour because of drowsiness.Therefore, develop determined curative effect with modern means of science and technology, quality controllable, dosage form advanced person, taking convenience, the anti-flu new Chinese medicine of no obvious adverse reaction is necessary, in case succeed in developing, economic and social benefit will be very remarkable all.
Summary of the invention
In order to address the above problem, the invention provides a kind of drowsiness anti-flu Chinese medicine sugar free granule of side effect, the prescription composition and preparation technology of tablet of waiting of generation when using that overcome.
Technical scheme of the present invention is as follows:
Prescription is formed: Radix Bupleuri 15-25g, Radix Scutellariae 3-10g, Herba Schizonepetae 3-10g, drugs for nourishing yin 5-20g, cold-dispelling drug 3-10g.
Wherein drugs for nourishing yin is the Radix Rehmanniae, and cold-dispelling drug is a Rhizoma Zingiberis Recens.
Preparation technology: baikal skullcap root decoction pieces is decocted, filters, and it is standby that filtrate suitably concentrates the back; Radix Bupleuri, Herba Schizonepetae, cold-dispelling drug are ground into coarse granule, soak the back distillation with the drugs for nourishing yin decoction pieces, it is standby to collect volatile oil, medicinal residues continue to decoct, collecting decoction, precipitate with ethanol behind the concentrating under reduced pressure filters, filtrate recycling ethanol, add the Radix Scutellariae fluid extract, continue to be concentrated into the relative density of regulation, add a certain amount of soluble dextrins parboiling, stir evenly, must do medicated powder after the spray drying; Volatile oil gets Benexate Hydrochloride with beta-schardinger dextrin-inclusion, drying, pulverizing.With dried medicated powder, Benexate Hydrochloride mixing, add other adjuvant again and be prepared into sugar free granule or tablet.
Modern study shows: Radix Bupleuri mainly contains volatile oil and saponin component, has antiinflammatory, analgesic, analgesia, calmness, antitussive, anticonvulsant action; It is the flavones ingredient of representative that Radix Scutellariae mainly contains with the baicalin, has effects such as antibiotic, antiviral, antiinflammatory, antiallergic action; Herba Schizonepetae contains a large amount of volatile oil, main component is pulegone, menthone, isopulegone, isomenthone etc. in the oil, have analgesic, cooling, calmness, analgesia, antiinflammatory action, the Radix Rehmanniae mainly contains iridoid glycoside constituents such as catalpol, aucubin, Martynoside., have antiinflammatory, regulate effects such as immunologic function; Rhizoma Zingiberis Recens contains volatile oil, and main component is zingiberene, phellandrene, santalol etc. in the oil, has effects such as analgesic, analgesia, calmness, antiinflammatory, convulsion, emesis and protection gastric mucosa.This shows, under Chinese medical theory instructs, it is little that the utilization modern means of science and technology are developed to dosage with it, and the bioavailability height is rapid-action, sugar free granule easy to use and sheet, the support of existing reliable clinical basis and Chinese medical theory has modern chemistry and pharmacological experiment result again as foundation, also meets the requirement of contemporary pharmacy theory about " triple effect " and " three is little " simultaneously, be to confirm mutually with the modern times ancient times, theory and practice is unified mutually.
This product is a pure Chinese medicinal preparation, and antibacterial experiment shows in the body: (1) this product 7.2g/kg and 14.4g/kg dosage group can reduce its mortality rate to the infection of staphylococcus aureus mice, relatively have significant difference (P<0.05) with the blank group; 3.6g/kg 7.2g/kg and 14.4g/kg dosage group can obviously prolong the time-to-live of mice, relatively have significant difference (P<0.05, P<0.01) with the blank group.(2) this product 3.6g/kg and 7.2g/kg dosage group can reduce its mortality rate and prolong the time-to-live of mice the Diplococcus pneumoniae infecting mouse, relatively have significant difference (P<0.05) with the blank group.Prompting: this product has certain vivo bacteria corrosion action.
The interior resisting virus test shows: this product 7.2g/kg and 14.4g/kg dosage group can obviously prolong the time-to-live of influenza a virus infection mice to influenza A virus (A/PR/8/34) infecting mouse, relatively have significant difference (P<0.05) with the virus control group.This product 14.4g/kg dosage group can obviously reduce the lung exponential quantity of influenza a virus infection mice, relatively has significant difference (P<0.05) with the virus control group, and lung index suppression ratio is 22.17%.Prompting: this product has the effect that certain anti-influenza A virus infects.
This product 14.4g/kg dosage group can obviously alleviate dimethylbenzene induced mice ear swelling, with model group significant difference (P<0.05) is arranged relatively, and prompting this product has certain antiinflammatory action, and the edema hyperemia early stage to inflammation has certain inhibitory action.This product 14.4g/kg dosage group increases the abdominal cavity capillary permeability due to the HAc significant inhibitory effect, and prompting this product has antiinflammatory action, but early stage edema, the hyperemia of inflammation-inhibiting and oozing out.
This product can alleviate acetic acid induced mice writhing response, illustrates that this product has certain analgesic activity to chemical stimulation, but not statistically significant.This product 14.4g/kg dosage group can obviously improve mice pain threshold (P<0.05), and prompting this product has certain analgesic activity to physical stimulation.
This product rat temperature due to the beer yeast is raise and escherichia coli endotoxin due to rabbit body temperature raise tangible antipyretic effect arranged, with model group comparison, significant difference (P<0.05).Prompting this product has certain refrigeration function.
In sum: this product has certain antibiotic, antiviral, antiinflammatory, analgesia, refrigeration function.
The specific embodiment
Prescription: Radix Bupleuri 15-25g, Radix Scutellariae 3-10g, Herba Schizonepetae 3-10g, Radix Rehmanniae 5-20g, Rhizoma Zingiberis Recens 310g.
Method for making: baikal skullcap root decoction pieces adds water, directly decocts 2 times, and each 1.5h, decocting liquid filter the back and merge, and be centrifugal, standby behind the centrifugal liquid concentrating under reduced pressure.
Radix Bupleuri, Herba Schizonepetae, Rhizoma Zingiberis Recens powder are broken into coarse granule, mix with Radix Rehmanniae decoction pieces, add water, soak 2h, distillation 3h, volatile oil device in addition deposit, and decocting liquid leaches, medicinal residues decoct with water 1.5h again, filter, and the secondary decocting liquid merges, be evaporated to about 1.10 (70 ℃) of relative density, be chilled to room temperature, adding ethanol is 80% to containing the alcohol amount, leave standstill more than the 12h, sucking filtration is behind the decompression recycling ethanol, add the Radix Scutellariae extracting solution, suitably concentrating under reduced pressure is weighed.
Add a certain amount of soluble dextrins, parboiling stirs evenly, and is adjusted to suitable relative density, spray drying.
Measure volatile oil, add 3 times of amount 95% ethanol dilutions, take by weighing 8 times of amounts (w/v) beta-schardinger dextrin-, adding water, to make concentration be 8%, heating makes dissolving fully, is transferred in colloid mill or the blender, is cooled to 45 ℃, and keep constant temperature about 45 ℃, and slowly dripping the ethanol liquid of volatile oil, the limit edged grinds or stirs, after adding, continue constant temperature and grind or stir 90min, airtight cold preservation 24h, sucking filtration after washing with a small amount of pond, is drained, 60~70 ℃ of drying under reduced pressure, porphyrize, airtight preservation.
Dry powder and the Benexate Hydrochloride got after the spray drying merge, and add right amount of auxiliary materials such as dextrin, steviosin, and behind the mixing, with the alcohol granulation of suitable concentration, drying, granulate promptly.
Or get dry powder after the spray drying, merge with Benexate Hydrochloride, add right amount of auxiliary materials such as dry starch, behind the mixing, with suitable concentration alcohol granulation, drying behind the granulate, adds right amount of auxiliary materials, mixing, tabletting are promptly.
Claims (6)
1, a kind of anti-flu Chinese medicine sugar free granule, tablet, its prescription consists of: Radix Bupleuri 15-25g, Radix Scutellariae 3-10g, Herba Schizonepetae 3-10g, drugs for nourishing yin 5-20g, cold-dispelling drug 3-10g.
2, prescription according to claim 1 is formed, and it is characterized in that drugs for nourishing yin is the Radix Rehmanniae, and cold-dispelling drug is a Rhizoma Zingiberis Recens.
3, a kind of anti-flu Chinese medicine sugar free granule, tablet, its preparation technology is: baikal skullcap root decoction pieces is decocted, filters, and it is standby that filtrate suitably concentrates the back; Radix Bupleuri, Herba Schizonepetae, cold-dispelling drug are ground into coarse granule, soak the back distillation with the drugs for nourishing yin decoction pieces, it is standby to collect volatile oil, medicinal residues continue to decoct, collecting decoction, precipitate with ethanol behind the concentrating under reduced pressure filters, filtrate recycling ethanol, add the Radix Scutellariae fluid extract, continue to be concentrated into the relative density of regulation, add a certain amount of soluble dextrins parboiling, stir evenly, must do medicated powder after the spray drying; Volatile oil gets Benexate Hydrochloride with beta-schardinger dextrin-inclusion, drying, pulverizing.With dried medicated powder, Benexate Hydrochloride mixing, add other adjuvant again and be prepared into sugar free granule or tablet.
4, preparation method according to claim 3, when it is characterized in that the decoction liquor precipitate with ethanol, concentration of alcohol is 80% (volumetric concentration), time of repose is more than 12 hours.
5, preparation method according to claim 3, it is characterized in that volatile oil beta-schardinger dextrin-inclusion, the amount ratio of beta-schardinger dextrin-and volatile oil is 4~8g: 0.5~1.5ml, the inclusion temperature is 45 ℃, and beta-schardinger dextrin-adds the solution that water is mixed with 8% (weight concentration), and volatile oil adds after measuring 95% ethanol dilutions with 3 times.
6, preparation method according to claim 3 is characterized in that the used correctives of sugar free granule is a steviosin; Used diluent is a dry starch during tablet granulation.
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CN 03132096 CN1285379C (en) | 2003-07-22 | 2003-07-22 | Recipe composition of cold-resisting Chinese medicine sugar-less granular powder and tablet and preparing process |
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Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101023990B (en) * | 2007-03-24 | 2010-05-19 | 刘景君 | Chinese readymade medicine for treating exogenous disease |
CN110946831A (en) * | 2019-12-19 | 2020-04-03 | 金陵药业股份有限公司 | Novel preparation process of traditional Chinese medicine composition |
-
2003
- 2003-07-22 CN CN 03132096 patent/CN1285379C/en not_active Expired - Fee Related
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101023990B (en) * | 2007-03-24 | 2010-05-19 | 刘景君 | Chinese readymade medicine for treating exogenous disease |
CN110946831A (en) * | 2019-12-19 | 2020-04-03 | 金陵药业股份有限公司 | Novel preparation process of traditional Chinese medicine composition |
CN110946831B (en) * | 2019-12-19 | 2022-03-01 | 金陵药业股份有限公司 | Novel preparation process of traditional Chinese medicine composition |
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