CN1480164A - Medication for treating diabetic retinopathy and its preparing method - Google Patents

Medication for treating diabetic retinopathy and its preparing method Download PDF

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Publication number
CN1480164A
CN1480164A CNA021328951A CN02132895A CN1480164A CN 1480164 A CN1480164 A CN 1480164A CN A021328951 A CNA021328951 A CN A021328951A CN 02132895 A CN02132895 A CN 02132895A CN 1480164 A CN1480164 A CN 1480164A
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semen
fructus
radix
rhizoma
medicine
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CN1201768C (en
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胡光伟
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Abstract

A Chinese medicine in the form of powder, pill, capsule, or tablet for treating diabetic retinosis is prepared from 23 Chinese-medicinal materials including haw, wolfberry fruit, astragalus root, yam, etc through drying, pulverizing, treating by solvent, drying in air, pulverizing, proportionally mixing, heating and sterilizing. Its advantage is high curative effect.

Description

Medicine that treatment of diabetic retinopathy becomes and preparation method thereof
Technical field: the present invention relates to the medicine that a kind of treatment of diabetic retinopathy becomes, specifically a kind of is the Chinese patent medicine of feedstock production with pure Chinese herbal medicine, the invention still further relates to the preparation method of this medicine.
Background technology: diabetes are lacking relatively and definitely owing to insulin in the blood, cause that sugar, fat, protein metabolism disorder cause hyperglycemia, hyperlipidemia, high blood viscosity, Gao Ning, disturbance of blood circulation, and causing cardiovascular, cerebrovascular, diabetes kidney function failure and retina become.
Diabetic renal papillary necrosis is with early stage pericyte's forfeiture basement membrane thickened, endothelial cell proliferation, late period the retinal capillary obturation, ooze out, hemorrhage and new vessels forms feature and causes hematocele in the vitreous body, proliferative retinopathy, detachment of retina, optic atrophy, degeneration of macula, finally causing losing one's sight, is the one of the main reasons of blinding.
At present, treatment does not still have than good method to primary disease both at home and abroad, runs into following thorny problem yet.
1, the side effect of biguanides curative effect is big, for a long time with producing hyperlactacidemia.
2, with infringement Liver and kidney and hemocyte and sulphonamides cross allergy, the later stage produces secondary failure to the iodine ureas for a long time.
3, with producing antibody, biological activity reduces insulin for a long time, and dosage increases, and produces insulinemia, and microangiopathies takes place and development.
When 4, adopting the laser therapy diabetic renal papillary necrosis, propagation early stage and propagation phase are effective ways, but also are a kind of destructive Therapeutic Method, to the destruction of the organizational structure of retinal neuronal cell, must not recover, so that vision continue to descend.
5, above various Therapeutic Method though blood glucose is controlled, can not stop and treat the generation and the development of retinopathy for the diabetic renal papillary necrosis unsatisfactory curative effect, finally still causes losing one's sight.Though the Chinese patent medicine that yet has some to control diabetes is not fairly obvious to the diabetic renal papillary necrosis effect.
Summary of the invention: the technical problem to be solved in the present invention provides medicine of a kind of treatment of diabetic retinopathy change and preparation method thereof.
Solution of the present invention is under Basic Theories of Chinese Medicine instructs, in conjunction with clinical practice, with replenishing YIN and removing heat, set upright QI invigorating, good in strengthening stomach and tonifying kidney, activating blood circulation to dissipate blood stasis, the dampness removing collateral dredging, softening and eliminating sputum, deficiency of both QI and YIN due to the change diabetes, the blood stasis stagnation of QI, the trend that deficiency of both YIN and YANG develops is the main blood sugar lowering that reaches, blood fat reducing, improve high blood coagulation, high viscosity and high coagulant state, the microcirculation improvement obstacle increases immunity of organisms, the diabetes-alleviating complication, cardiovascular pathological changes, cerebrovascular disease, diabetic nephropathy and treatment of diabetic retinopathy become institute and cause retinal edema, ooze out, vitreous hemorrhage due to hemorrhage, optic atrophy is degeneration of macula, proliferative retinopathy, the control detachment of retina prevents to lose one's sight.According to traditional Chinese medical science treating the same disease with different methods, the principle for the treatment of different diseases with the same therapeutic principle, medicine provided by the invention is for the retinopathy due to other reason, degeneration of macula, optic atrophy, retinal hemorrhage are all received curative effect preferably.
Medicine of the present invention is made (consumption is a weight portion) by following component: Fructus Crataegi 2-10, Semen Cassiae 3-10, Cortex Phellodendri 2-10, Fructus Lycii 3-15, Semen Cuscutae 2.5-7.5 Radix Astragali 5-20, Radix Codonopsis 5-15, Radix Rehmanniae 2-10, pollen 3-8.5, Herba Dendrobii 5-20, Rhizoma Pinelliae 2-5, Rhizoma Dioscoreae 6-15, Rhizoma Atractylodis 2.5-7.5, Fructus Aurantii 2.5-7.5, Semen Plantaginis 2.5-7.5, Flos Carthami 2-15, Semen Persicae 2-10, Radix Angelicae Sinensis 5-15, Chang foretells 3-8.5, volt Siberian cocklebur 2-15 Fructus Schisandrae Chinensis 3-8.5 Herba Agrimoniae 2-8, Sargassum 2-8.
The formula optimization weight proportion scope of preparation medicine of the present invention is: Fructus Crataegi 3-5 Semen Cassiae 4-6 Cortex Phellodendri 3-5 Fructus Lycii 5-8 Semen Cuscutae 3-5 Radix Astragali 8-10 Radix Codonopsis 5-8 Radix Rehmanniae 2.5-3.5 pollen 4-6 Herba Dendrobii 8-10 Rhizoma Pinelliae 2.5-3.5 Rhizoma Dioscoreae 8-10 Rhizoma Atractylodis 3-5 Fructus Aurantii 3-5 Semen Plantaginis 3-5 Flos Carthami 5-8 Semen Persicae 2.5-3.5 Radix Angelicae Sinensis 5-8 Chang foretells 4-6 Poria 3-5 Fructus Schisandrae Chinensis 4-6 Herba Agrimoniae 2-6 Sargassum 2-6.
The optimum weight proportioning of medicine of the present invention is: Fructus Crataegi 4 Semen Cassiae 5 Cortex Phellodendris 4 Fructus Lyciis 6 Semen Cuscutae 4 Hemerocallis citrina Baronis 9 Radix Codonopsis 6 Radix Rehmanniae 3 pollen 5 Herba Dendrobiis 9 Rhizoma Pinelliaes 3 Rhizoma Dioscoreaes 9 Rhizoma Atractylodis 4 Fructus Aurantiis 4 Semen Plantaginiss 4 Flos Carthamis 6 Semen Persicaes 3 Radix Angelicae Sinensis 6 Chang foretell 5 Poria, 4 Fructus Schisandrae Chinensis, 5 Herba Agrimoniaes, 3 Sargassums 3.
Above-mentioned each component is made medicine production method of the present invention is:
1, gets Fructus Crataegi, drying and crushing to 120 order fine powder earlier;
2, with Fructus Lycii, Fructus Schisandrae Chinensis, the Radix Rehmanniae after-15 ℃ of following lyophilizations, add to be ground into 120 order fine powders;
3, get the Rhizoma Pinelliae tuber and dry, grind powder then and cross 120 order fine powders with 8% white alum solution immersion taking-up in 5 days;
4, get Semen Cassiae, Semen Cuscutae, Semen Plantaginis, Fructus Aurantii, Chang fore-telling, Radix Angelicae Sinensis, Cortex Phellodendri, Radix Codonopsis, Semen Persicae, Rhizoma Atractylodis, Herba Dendrobii respectively lyophilized powder be broken into 120 order fine powders;
5, Rhizoma Dioscoreae, Poria, the Radix Astragali, Flos Carthami, Herba Agrimoniae, Sargassum are ground into 120 order fine powders after air-dry;
6, with above-mentioned whole powder components by after the described mixed, carry out ripening, sterilization treatment 10-30 minute at 100-110 ℃, can obtain controlling the powder medicine of diabetic renal papillary necrosis.
The ripening disinfecting action here is to adopt step type cooling ripening sterilization, temperature is ordered being raised to 110 ℃ rapidly, and segmentation drops to 100 ℃ then, and the ripening sterilization time is 10-30 minute.
Powder after the maturation process can also routine make pill respectively, also can be reprocessed into tablet, capsule.
Clinical drug of the present invention uses the result to show that following advantage is arranged:
1, to select the pure natural plant medicine for use be raw material in the present invention, do not have any western medicine composition, and each component meets the pharmaceutical control law regulation, utilizes the comprehensive function treatment of diabetic retinopathy of the Chinese medicine of respectively distinguishing the flavor of to become, nontoxic to human body.
2, this medicine can be made into pill, capsule, powder, tablet and meets state food health legislation regulation through agent.
3, light disease can be used separately, can use with other antidiabetic drugs and insulin combination than severe disease disease, and therapeutic effect obviously increases, and can alleviate other complication of diabetes, the enhancing human body immunity power eliminated significantly.
The specific embodiment:
Embodiment 1
Take by weighing raw material Fructus Crataegi 20kg, Semen Cassiae 25kg, Cortex Phellodendri 20kg, Fructus Lycii 30kg, Semen Cuscutae 20kg, Radix Astragali 45kg, Radix Codonopsis 30kg, Radix Rehmanniae 15kg, pollen 25kg, Herba Dendrobii 45kg, Rhizoma Pinelliae 15kg, Rhizoma Dioscoreae 45kg, Rhizoma Atractylodis 20kg, Fructus Aurantii 20kg, Semen Plantaginis 20kg, Flos Carthami 30kg, Semen Persicae 15kg, Radix Angelicae Sinensis 30kg, Chang fore-telling 25kg, Poria 20kg, Fructus Schisandrae Chinensis 25kg Herba Agrimoniae 15kg, Sargassum 15kg by following proportioning.
Production method is as follows:
Earlier the Fructus Crataegi drying is crushed to 120 order fine powders; Again with Fructus Lycii, Fructus Schisandrae Chinensis, the Radix Rehmanniae after-15 ℃ of lyophilizations, processing powder is broken into 120 order fine powders; Get Rhizoma Pinelliae tuber again and soak to take out in 5 days with 8% white alum solution and dry, grind the powder 120 order fine powders of looking over so as to check then; Get Semen Cassiae, Semen Cuscutae, Semen Plantaginis, Fructus Aurantii, Chang fore-telling, Radix Angelicae Sinensis, Cortex Phellodendri, Radix Codonopsis, Semen Persicae, Rhizoma Atractylodis, Herba Dendrobii respectively lyophilized powder be broken into 120 order powder; Rhizoma Dioscoreae, Hua Ling, the Radix Astragali, Flos Carthami, Herba Agrimoniae, Sargassum are ground into 120 order fine powders after air-dry; After above-mentioned various fine powder components are pressed formula proportion and mix, 110 ℃ of insulations 10 minutes down, and then cool to 105 ℃ of insulations 5 minutes, and then heat, carry out the ripening sterilization, make powder to 100 ℃ of insulations 15 minutes.

Claims (5)

1, the medicine that a kind of treatment of diabetic retinopathy becomes, it is characterized in that: it is the medicament of being made by following weight proportioning raw material (consumption is a weight portion): Fructus Crataegi 2-10, Semen Cassiae 3-10, Cortex Phellodendri 2-10, Fructus Lycii 3-15, Semen Cuscutae 2.5-7.5 Radix Astragali 5-20, Radix Codonopsis 5-15, Radix Rehmanniae 2-10, pollen 3-8.5, Herba Dendrobii 5-20, Rhizoma Pinelliae 2-5, Rhizoma Dioscoreae 6-15, Rhizoma Atractylodis 2.5-7.5, Fructus Aurantii 2.5-7.5, Semen Plantaginis 2.5-7.5, Flos Carthami 2-15, Semen Persicae 2-10, Radix Angelicae Sinensis 5-15, Chang foretells 3-8.5, volt Siberian cocklebur 2-15 Fructus Schisandrae Chinensis 3-8.5 Herba Agrimoniae 2-8, Sargassum 2-8.
2, the medicine of treatment of diabetic retinopathy change according to claim 1, wherein the weight proportion of each raw material is: Fructus Crataegi 3-5 Semen Cassiae 4-6 Cortex Phellodendri 3-5 Fructus Lycii 5-8 Semen Cuscutae 3-5 Radix Astragali 8-10 Radix Codonopsis 5-8 Radix Rehmanniae 2.5-3.5 pollen 4-6 Herba Dendrobii 8-10 Rhizoma Pinelliae 2.5-3.5 Rhizoma Dioscoreae 8-10 Rhizoma Atractylodis 3-5 Fructus Aurantii 3-5 Semen Plantaginis 3-5 Flos Carthami 5-8 Semen Persicae 2.5-3.5 Radix Angelicae Sinensis 5-8 Chang foretells 4-6 Poria 3-5 Fructus Schisandrae Chinensis 4-6 Herba Agrimoniae 2-6 Sargassum 2-6.
3, the medicine of treatment of diabetic retinopathy change according to claim 1, wherein the weight proportion of each raw material is: Fructus Crataegi 4 Semen Cassiae 5 Cortex Phellodendris 4 Fructus Lyciis 6 Semen Cuscutae 4 Hemerocallis citrina Baronis 9 Radix Codonopsis 6 Radix Rehmanniae 3 pollen 5 Herba Dendrobiis 9 Rhizoma Pinelliaes 3 Rhizoma Dioscoreaes 9 Rhizoma Atractylodis 4 Fructus Aurantiis 4 Semen Plantaginiss 4 Flos Carthamis 6 Semen Persicaes 3 Radix Angelicae Sinensis 6 Chang foretell sub 5 Herba Agrimoniaes, 3 Sargassums 3 of 5 Poria, 4 flavors.
4, the medicine that becomes according to claim 1,2 or 3 described treatment of diabetic retinopathy is characterized in that; Said medicament is said powder, pill, capsule, a tablet on the pharmaceutics.
5, follow the preparation method of the medicine that becomes according to the described treatment of diabetic retinopathy of claim 4, it is characterized in that: get Fructus Crataegi earlier, drying and crushing to 120 order fine powder; After-15 ℃ of following lyophilizations, processing powder is broken into 120 order fine powders with Fructus Lycii, Fructus Schisandrae Chinensis, the Radix Rehmanniae; Getting the Rhizoma Pinelliae tuber soaks to take out in 5 days to dry with 8% white alum solution and grinds powder then and cross 120 fine powders; Get Semen Cassiae, Semen Cuscutae, Semen Plantaginis, Fructus Aurantii, Chang fore-telling, Radix Angelicae Sinensis, Cortex Phellodendri, Radix Codonopsis, Semen Persicae, Rhizoma Atractylodis, Herba Dendrobii lyophilizing respectively, be ground into 120 order fine powders; Be ground into 120 order fine powders after Rhizoma Dioscoreae, Poria, Hemerocallis citrina Baroni, Flos Carthami, Herba Agrimoniae, Sargassum are air-dry, above-mentioned various fine powder components were carried out the ripening sterilization treatment 10-30 minute after by described mixed under 100-110 ℃ of temperature, make powder.
CN 02132895 2002-09-06 2002-09-06 Medication for treating diabetic retinopathy and its preparing method Expired - Fee Related CN1201768C (en)

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Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101979040A (en) * 2010-10-26 2011-02-23 左权县蓝天中药科技开发有限公司 Medicament for treating central serous chorioretinopathy
CN104857219A (en) * 2015-06-19 2015-08-26 济南邦文医药科技有限公司 Traditional Chinese medicine for treating mild diabetic macular edema
CN105362524A (en) * 2015-12-14 2016-03-02 青岛华仁太医药业有限公司 Traditional Chinese medicine composition for treating retinitis and preparation method of traditional Chinese medicine composition
CN108079184A (en) * 2016-11-21 2018-05-29 广州白云山中药业有限公司 Chinese medicine composition is preparing the application in preventing diabetic retinopathy drug

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101979040A (en) * 2010-10-26 2011-02-23 左权县蓝天中药科技开发有限公司 Medicament for treating central serous chorioretinopathy
CN104857219A (en) * 2015-06-19 2015-08-26 济南邦文医药科技有限公司 Traditional Chinese medicine for treating mild diabetic macular edema
CN105362524A (en) * 2015-12-14 2016-03-02 青岛华仁太医药业有限公司 Traditional Chinese medicine composition for treating retinitis and preparation method of traditional Chinese medicine composition
CN108079184A (en) * 2016-11-21 2018-05-29 广州白云山中药业有限公司 Chinese medicine composition is preparing the application in preventing diabetic retinopathy drug
CN108079184B (en) * 2016-11-21 2020-05-19 广州白云山中一药业有限公司 Application of traditional Chinese medicine composition in preparation of medicine for preventing and treating diabetic retinopathy

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