CN1478492A - Medicine for treating arthritis pain and its preparation method - Google Patents
Medicine for treating arthritis pain and its preparation method Download PDFInfo
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- CN1478492A CN1478492A CNA02128136XA CN02128136A CN1478492A CN 1478492 A CN1478492 A CN 1478492A CN A02128136X A CNA02128136X A CN A02128136XA CN 02128136 A CN02128136 A CN 02128136A CN 1478492 A CN1478492 A CN 1478492A
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Abstract
A Chinese medicine for treating arthrodynia is prepared from 10 Chinese-medicinal materials including Sichuan aconite root, wild aconite root, frankincense, myrrh, etc. Its advantages are high curative effect and no toxic by-effect.
Description
Technical field
The present invention relates to a kind of medicine for the treatment of arthralgia, relating in particular to a kind of is the medicine for external use of primary raw material preparation with the Chinese herbal medicine, the invention still further relates to the preparation method of this medicine.
Background technology
Chronic arthralgia (non-infectious) is the common clinical symptoms of a class, can cause by the multiple reason of rheumatism, rheumatoid, scapulohumeral periarthritis, cervical spondylosis or the like, mainly show as arthralgia, muscle weakness and dysfunction in various degree, can there be the swelling tenderness part, amyotrophy etc., severe patient arthrogryposis deformity, even disable.For this treatment of diseases, Chinese and western medicine common method and medicine are a lot, but curative effect is undesirable, and untoward reaction is all arranged during medication and after the drug withdrawal, and the toxic and side effects that has is also very big.At present Chinese medicine comprises two kinds of medicine for external use and oral medicine, and oral medicine has certain toxic and side effects to human body, and gastrointestinal tract is also had certain stimulation.Externally applied ointment described in " a kind of medicine and preparation method and application for the treatment of osteoarthritis " is disclosed among the Chinese patent publication number CN1369299A, the plaster class is pasted for a long time in the part can cause certain injury to skin, and general medicine for external use is difficult for absorbing, and curative effect is not obvious.
Summary of the invention
There is demand in the medicine of therefore, people's commute absorption, good effect and the treatment osteoarthritis that can not damage local skin.Up to now, also do not find the report of any relevant medicine of the present invention.The inventor is through research repeatedly, and the checking repeatedly by animal and clinical trial, has found the external Miao Ethnomedicine of therapeutic effect obvious treatment osteoarthritis finally, thereby has finished the present invention.
The object of the present invention is to provide a kind of dispelling cold and removing dampness, promoting blood circulation to remove obstruction in the collateral, reducing swelling and alleviating pain, therapeutic effect is good, effective percentage is high, have no side effect and to the medicine of the non-stimulated treatment arthralgia of skin.
Another object of the present invention is to provide the preparation method of this medicine.
The disease kind that causes arthralgia belongs to the traditional Chinese medical science " arthromyodynia " category, and motherland's medical science thinks that primary disease is many because of deficiency of the liver and kindey, the damp of having a cold outward, and pathogenic factor is kept somewhere muscle, and the meridians joint causes the QI and blood passages through which vital energy circulates stasis of blood to stagnate, and obstructed of impatency is a pain.Medicine of the present invention according to Seedling medical science to " arthromyodynia " pathogenetic understanding, " is usefulness to lead to " legislation, select mainly to comprise that Chinese medicine such as Lysimachia trientaloides Hemsl., Cymbidium floribundum lindl grass, Radix Aconiti, Radix Aconiti Kusnezoffii, Olibanum, Myrrha, Realgar, Rhizoma Arisaematis, Herba Asari, Rhizoma Gastrodiae and Miao Ethnomedicine make up, make each efficacy of drugs produce synergism these drug regimens, thereby treat arthralgia effectively.
The consumption of drug component of the present invention is also groped to sum up to draw through the inventor in a large number, and each amounts of components is for all to have better curative effect in the following weight parts scope:
Lysimachia trientaloides Hemsl. 10-30 part Cymbidium floribundum lindl grass 10-30 part Radix Aconiti 10-30 part
Radix Aconiti Kusnezoffii 10-30 part Olibanum 10-30 part Myrrha 10-30 part
Realgar 10-20 part Rhizoma Arisaematis 10-30 part Herba Asari 10-30 part
Rhizoma Gastrodiae 10-20 part
Be preferably:
20 parts of 15 portions of Radix Aconitis of Lysimachia trientaloides Hemsl. 15 parts of Cymbidium floribundum lindls grass
10 parts of 10 parts of Myrrhas of 20 parts of Olibanums of Radix Aconiti Kusnezoffii
15 parts of 15 parts of Herba Asaris of 10 parts of Rhizoma Arisaematis of Realgar
10 parts in Rhizoma Gastrodiae
The preparation method of medicine activity component of the present invention is:
With Lysimachia trientaloides Hemsl., Cymbidium floribundum lindl grass, Radix Aconiti, Radix Aconiti Kusnezoffii, Olibanum, Myrrha, Realgar, Rhizoma Arisaematis, Herba Asari, the Rhizoma Gastrodiae of described weight proportion, to pulverize, addition was soaked 20-60 days for ning 65% ethanol of 3 times of powder, filtration, filtrate is the tincture of medicine of the present invention.
Can add the required adjuvant of spray in the medicine filtrate of the present invention, make spray according to a conventional method.
Medicine of the present invention, external massage pathological changes part, make the direct osmotic absorption of medicine, form higher drug level at affected part, make that therapeutic effect is good, effective percentage is high, have following treatment characteristics: (1) improves the local organization blood circulation, the absorption of softening local fiber adhesion and promotion adhesion, thereby the recovery of promotion function of joint; (2) tangible reducing swelling and alleviating pain, the expelling wind and removing dampness effect; (3) all have the obvious anti-inflammatory and anti effect for nonspecific inflammation or immune inflammation, course of disease progress capable of blocking promotes its rehabilitation.
The specific embodiment
Below further sets forth the beneficial effect of medicine of the present invention by testing example, acute oral toxicity test, the skin irritation that these tests are routine to have comprised medicinal tincture of the present invention tests and clinical observation on the therapeutic effect is tested.
Test example 1: the acute oral toxicity test of medicine of the present invention
(1) experiment purpose
Observe per os of animal subject and give untoward reaction and the death condition that animal causes, and definite median lethal dose(LD 50) (LD
50).
(2) material and usage
Tried thing: medicinal tincture of the present invention
Animal: white mice, body weight 18-22g.
Dosage and administering mode: tried thing and establish 2.15,4.64,10.0 and four dosage groups of 21.5g/kg body weight.Prepare with distilled water.Press the 0.2ml/g body weight and calculate the contamination amount.10 animals of each metering group, female, hero half and half.Fasting 16 hours adopts a per os to irritate the stomach mode.
Observation index: after the contamination, observe general situation, poisoning symptom and the death condition of animal, observe two weeks of time limit.Press the HomShi method, obtain median lethal dose(LD 50), and definite acute toxicity classification.
(3) experimental result
| Sex | Dosage grouping (g/kg) | Number of animals (only) | Dead animal number (only) | Mortality rate (%) |
| ????♀ | ????2.15 | ????5 | ????0 | ????0 |
| ????♀ | ????4.64 | ????5 | ????0 | ????0 |
| ????♀ | ????10.0 | ????5 | ????0 | ????0 |
| ????♀ | ????21.5 | ????5 | ????4 | ????80 |
| ????♂ | ????2.15 | ????5 | ????0 | ????0 |
| ????♂ | ????4.64 | ????5 | ????0 | ????0 |
| ????♂ | ????10.0 | ????5 | ????0 | ????0 |
| ????♂ | ????21.5 | ????5 | ????4 | ????80 |
After the contamination, except that the 4th group, other animal has no adverse reaction, poisoning symptom and death condition occur, and therefore, this is tried thing to female, the male per os LD of white mice
50=9.26, fiducial limit 6.36-13.5, LD
50All, belong to actual nontoxic level greater than the 5.0g/kg body weight.
Test example 2: acute skin irritation test
(1) experiment purpose
The local reversibility inflammatory that produces changed after the coating of observation skin was tried thing.
(2) material and method
Tried thing: medicinal tincture of the present invention
Animal: new zealand white rabbit
Test method:
1) tested the day before yesterday, new zealand white rabbit back spinal column diamond wool was cut left and right each the about 6cm of unhairing scope
2
2) during formal test, will be tried thing 0.1ml and evenly be spread upon on four layers of gauze of 2.5*2.5cm, and be attached at side reuse adhesive plaster and fixed.Application time 24h.The right side skin of unhairing is made blank.
3) remove and tried behind the thing 1,24,48 hour, observe dermoreaction respectively, send out in [1999] No. 577 according to defending the method prison that skin irritation test card 1 and table 2 carry out scoring of skin irritation melon and skin irritation strength grading in the security procedures evaluation and method.
(3) experimental result
| Number of animals | Sex | Body weight (kg) | Skin irritation reaction scoring | |||||||||||
| ?????????????1h | ????????????24h | ????????????48h | ||||||||||||
| Erythema | Edema | Erythema | Edema | Erythema | Edema | Erythema | Edema | Erythema | Edema | Erythema | Edema | |||
| Sample | Right | Sample | Right | Sample | Right | |||||||||
| ??1 | ???♀ | ????2.0 | ???0 | ???0 | ???0 | ???0 | ???0 | ???0 | ???0 | ???0 | ???0 | ???0 | ???0 | ???0 |
| ??2 | ???♀ | ????2.0 | ???0 | ???0 | ???0 | ???0 | ???0 | ???0 | ???0 | ???0 | ???0 | ???0 | ???0 | ???0 |
| ??3 | ???♂ | ????2.1 | ???0 | ???0 | ???0 | ???0 | ???0 | ???0 | ???0 | ???0 | ???0 | ???0 | ???0 | ???0 |
| ???4 | ???♂ | ????2.2 | ????0 | ????0 | ????0 | ????0 | ????0 | ????0 | ????0 | ????0 | ????0 | ????0 | ????0 | ????0 |
| Integral mean value | ????0 | ????0 | ????0 | ????0 | ????0 | ????0 | ????0 | ????0 | ????0 | ????0 | ????0 | ????0 | ||
| Stimulus intensity | Nonirritant | |||||||||||||
(4) conclusion
Result of the test shows, tried thing and once contacts animal and do not cause that skin irritation reacts, and belongs to nonirritant.
Test example 3: the clinical observation of medicinal tincture of the present invention
(1) physical data
Whole case 641 examples, the double-blind method stochastic sampling is divided into 2 groups, carries out observation of curative effect.
Treatment group: totally 328 examples, male's 168 examples wherein, women's 170 examples, maximum 72 years old age, minimum 25 years old, 45 years old mean age.
Matched group: totally 313 examples, male's 146 examples, women's 167 examples, the oldest 70 years old, minimum 28 years old, 42 years old mean age.
(2) disease distributes
Medical diagnosis on disease is diagnosed according to " practical orthopaedics and tranmstology) " (second edition) diseases related diagnostic criteria.
Treatment group: traumatic arthritis 74 examples, scapulohumeral periarthritis 78 examples, osteoarthritis 64 examples, rheumatoid arthritis 58 examples, cervical vertebra pain 54 examples.
Matched group: traumatic arthritis 71 examples, scapulohumeral periarthritis 70 examples, osteoarthritis 61 examples, rheumatoid arthritis 56 examples, cervical vertebra pain 55 examples.
(2) Therapeutic Method
The treatment group adopts medicinal tincture of the present invention, and matched group adopts rheumatic pain killing tincture (commercially available).
Treatment group and matched group all adopt the identical treatment method, the cleaning local skin, taking liquid 5-10ml dabs pain part (scope of applying medicinal lotion or ointment is big slightly than the pain scope), then by gently to the heavy massage part, heating gets final product, and soaks into the medicinal liquid soak local 20 minutes with absorbent cotton again, treats every day 2 times, 7 is a course of treatment, treats 3 courses of treatment altogether.
(4) therapeutic effect
1) curative effect judging standard:
Produce effects: arthralgia disappears, and functional activity recovers.
Effectively: arthralgia obviously alleviates, and functional activity partly recovers.
Invalid: curative effect is not obvious
| The sick kind | The example number | Produce effects | Effectively | Invalid | Total effective rate | |||||
| Control | Right | Control | Right | Control | Right | Control | Right | Control | Right | |
| Traumatic arthritis | ???74 | ??71 | ??32 | ??18 | ???37 | ???29 | ???5 | ???24 | ????93％ | ????66.2％ |
| Scapulohumeral periarthritis | ???78 | ??70 | ??52 | ??14 | ???23 | ???27 | ???3 | ???29 | ????96％ | ????58.6％ |
| Osteoarthritis | ???64 | ???61 | ??21 | ??10 | ???36 | ???22 | ???7 | ???29 | ????89.1％ | ????52％ |
| Rheumatoid arthritis | ???58 | ??56 | ??12 | ??9 | ???40 | ???16 | ???6 | ???31 | ????89.7％ | ????26.8％ |
| Cervical spondylosis | ???54 | ???55 | ??13 | ??4 | ???35 | ???18 | ???6 | ???33 | ????88.9％ | ????40％ |
2) untoward reaction (during the treatment)
The treatment group: the slight erythema of local skin appears in 3 examples, and drug withdrawal was died away on the 2nd.
Matched group: 7 examples occur localized erythema and in various degree erythra companion scratch where it itches, in time handle through drug withdrawal, disappear after 5 days.
(5) conclusion
Above statistics show that medicine of the present invention is 91.8% to the arthralgia total effective rate, and matched group only is 53%, and P＜0.05 has significant diversity.
Embodiment 1
Take by weighing raw material by following amount:
Lysimachia trientaloides Hemsl. 10g Cymbidium floribundum lindl grass 10g Radix Aconiti 10g
Radix Aconiti Kusnezoffii 10g Olibanum 10g Myrrha 10g
Realgar 10g Rhizoma Arisaematis 10g Herba Asari 10g
Rhizoma Gastrodiae 10g
Preparation method is as follows: with Lysimachia trientaloides Hemsl., Cymbidium floribundum lindl grass, Radix Aconiti, Radix Aconiti Kusnezoffii, Olibanum, Myrrha, Realgar, Rhizoma Arisaematis, Herba Asari, the Rhizoma Gastrodiae of above-mentioned weight, pulverize, addition was soaked 20-60 days for there be not 65% ethanol of 3 times of powder, filter, filtrate is the tincture of medicine of the present invention.
Embodiment 2
Take by weighing raw material by following amount:
Lysimachia trientaloides Hemsl. 15g Cymbidium floribundum lindl grass 15g Radix Aconiti 20g
Radix Aconiti Kusnezoffii 20g Olibanum 10g Myrrha 10g
Realgar 10g Rhizoma Arisaematis 15g Herba Asari 15g
Rhizoma Gastrodiae 10g
Preparation method is as follows: with Lysimachia trientaloides Hemsl., Cymbidium floribundum lindl grass, Radix Aconiti, Radix Aconiti Kusnezoffii, Olibanum, Myrrha, Realgar, Rhizoma Arisaematis, Herba Asari, the Rhizoma Gastrodiae of above-mentioned weight, pulverize, addition was soaked 20-60 days for there be not 65% ethanol of 3 times of powder, filter, filtrate is the tincture of medicine of the present invention.
Embodiment 3
Take by weighing raw material by following amount:
Lysimachia trientaloides Hemsl. 30g Cymbidium floribundum lindl grass 30g Radix Aconiti 30g
Radix Aconiti Kusnezoffii 30g Olibanum 30g Myrrha 30g
Realgar 20g Rhizoma Arisaematis 30g Herba Asari 30g
Rhizoma Gastrodiae 20g
Preparation method is as follows: with Lysimachia trientaloides Hemsl., Cymbidium floribundum lindl grass, Radix Aconiti, Radix Aconiti Kusnezoffii, Olibanum, Myrrha, Realgar, Rhizoma Arisaematis, Herba Asari, the Rhizoma Gastrodiae of above-mentioned weight, pulverize, addition was soaked 20-60 days for there be not 65% ethanol of 3 times of powder, filter, filtrate is the tincture of medicine of the present invention.
Claims (3)
1, a kind of medicine for the treatment of arthralgia is characterized in that it mainly comprises following raw medicaments in portion by weight:
Lysimachia trientaloides Hemsl. 10-30 part Cymbidium floribundum lindl grass 10-30 part Radix Aconiti 10-30 part
Radix Aconiti Kusnezoffii 10-30 part Olibanum 10-30 part Myrrha 10-30 part
Realgar 10-20 part Rhizoma Arisaematis 10-30 part Herba Asari 10-30 part
Rhizoma Gastrodiae 10-20 part
2, the medicine of treatment arthralgia as claimed in claim 1 is characterized in that the consumption of each crude drug is:
20 parts of 15 portions of Radix Aconitis of Lysimachia trientaloides Hemsl. 15 parts of Cymbidium floribundum lindls grass
10 parts of 10 parts of Myrrhas of 20 parts of Olibanums of Radix Aconiti Kusnezoffii
15 parts of 15 parts of Herba Asaris of 10 parts of Rhizoma Arisaematis of Realgar
10 parts in Rhizoma Gastrodiae
3, the preparation method of medicine as claimed in claim 1 or 2 is characterized in that:
With Lysimachia trientaloides Hemsl., Cymbidium floribundum lindl grass, Radix Aconiti, Radix Aconiti Kusnezoffii, Olibanum, Myrrha, Realgar, Rhizoma Arisaematis, Herba Asari, the Rhizoma Gastrodiae of described weight proportion, to pulverize, addition was soaked 20-60 days for ning 65% ethanol of 3 times of powder, filtration, filtrate is the tincture of medicine of the present invention.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB02128136XA CN1186058C (en) | 2002-12-26 | 2002-12-26 | Medicine for treating arthritis pain and its preparation method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB02128136XA CN1186058C (en) | 2002-12-26 | 2002-12-26 | Medicine for treating arthritis pain and its preparation method |
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| Publication Number | Publication Date |
|---|---|
| CN1478492A true CN1478492A (en) | 2004-03-03 |
| CN1186058C CN1186058C (en) | 2005-01-26 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB02128136XA Expired - Fee Related CN1186058C (en) | 2002-12-26 | 2002-12-26 | Medicine for treating arthritis pain and its preparation method |
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| Country | Link |
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| CN (1) | CN1186058C (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100420473C (en) * | 2005-09-11 | 2008-09-24 | 王浩贵 | Externally applied medicine of dunn tongoloa root |
| CN102008655A (en) * | 2010-04-27 | 2011-04-13 | 泰一和浦（北京）中医药研究院有限公司 | Traditional Chinese medicine composition for treating arthralgia and preparation method thereof |
| CN101513477B (en) * | 2008-12-10 | 2011-05-04 | 新晃侗族自治县中医院 | Analgesic medicine for external application and method for preparing same |
-
2002
- 2002-12-26 CN CNB02128136XA patent/CN1186058C/en not_active Expired - Fee Related
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100420473C (en) * | 2005-09-11 | 2008-09-24 | 王浩贵 | Externally applied medicine of dunn tongoloa root |
| CN101513477B (en) * | 2008-12-10 | 2011-05-04 | 新晃侗族自治县中医院 | Analgesic medicine for external application and method for preparing same |
| CN102008655A (en) * | 2010-04-27 | 2011-04-13 | 泰一和浦（北京）中医药研究院有限公司 | Traditional Chinese medicine composition for treating arthralgia and preparation method thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1186058C (en) | 2005-01-26 |
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