CN1471979A - Artificial skin and producing method thereof - Google Patents
Artificial skin and producing method thereof Download PDFInfo
- Publication number
- CN1471979A CN1471979A CNA021284334A CN02128433A CN1471979A CN 1471979 A CN1471979 A CN 1471979A CN A021284334 A CNA021284334 A CN A021284334A CN 02128433 A CN02128433 A CN 02128433A CN 1471979 A CN1471979 A CN 1471979A
- Authority
- CN
- China
- Prior art keywords
- artificial skin
- chitin
- fiber
- wound
- jet
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Images
Landscapes
- Materials For Medical Uses (AREA)
Abstract
An artificial skin is prepared from the chitin fibre net with reticular fine structure and high-absorbability ordinary hydro-entangled fabric through combining by hydro-entangling, treating by antibiotic, sticking to air-permeable water-proof film in dot contact mode, and radiation sterilizing. Its advantages are high absorbability, proper air permeability, better biologic compatibility, and good antibacterial, antiinflammatory, staltic and antalgic effects.
Description
Technical field the present invention relates to a kind of artificial skin and manufacture method thereof.
Background technology is present, utilizes the medical process program that absorbs artificial skin of chitin fiber processing and manufacturing to mainly contain following several:
1) chitin fiber is adopted paper technology be processed into chitin fiber paper or adopt sizing technique to be processed into the chitin bonded nonwoven, make artificial skin through deep processing, artificial skin flexibility, breathability that this scheme is made are poor, easily aging, be difficult for preserving and having foreign body, the abnormal flavour that brings in the starching process, influence clinical efficacy.
2) chitin is adopted filming technology make the flaky chitin diaphragm of thin film artificial skin, disclose flaky artificial skin of a kind of thin film and manufacture method thereof as CN1049838C, its major defect is: breathability is poor, and is easily aging, easily make wound too moist, indolence.
3) chitin fiber is adopted common nonwoven processes become pure chitin artificial skin, this artificial skin breathability is too strong, and performance of keeping humidity is poor, can not control the evaporation of wound fluid effectively, easily makes wound too drying, incrustation, adhesion, the influence healing.
Up-to-date medical research shows, in clinical treatment, is accelerating wound, promotes the body cell growth, and the skin injury need keep certain wetting state, promptly requires the wound can not overdrying, again can not excessive moisture.More than the artificial skin made of several process programs in therapeutic process because the restriction of itself structure, the environment that build a suitable skin, human body growth often can not for the skin injury, thereby affect the treatment.
Summary of the invention the objective of the invention is to propose a kind of manufacture method of artificial skin.It is that raw material adopts jet to become the artificial skin of the chitin fiber multi-layer compound structure with good biological activity, biocompatibility, antibiotic, ventilative, coagulant blood function of preserving moisture of net complex technique production with the chitin that another kind of purpose of the present invention provides a kind of.
The object of the present invention is achieved like this: the manufacture method that proposes a kind of artificial skin.Described method comprises the steps:
A) viscose staple fibre or cotton short fiber etc. is had high liquid-absorbing can general fibre make the spun-laced nonwoven fabric (2) of certain grammes per square metre according to common water jet process.
B) with chitin fiber (1) by the carding machine carding, it is tentatively fixed to utilize high-pressure spray that fibre web is carried out by jet I district then, again with debatching under the spun laced fabric that makes of a) step compound, through jet II district mesohigh jet carry out fixed, put in order.
C) with b) the fixed multi-layer compound structure material that forms of step fully soaks into by the antibiolics groove, again drying, batch and make coiled material.
D) with c) coiled material debatching that step makes, on the hot melt compounding machine, carry out compound with breathing waterproof film (4).Adopt the point-like contact bonding, contact area accounts for the 10-30% of whole area coverage, can effectively control the evaporation capacity and the Air permenbility of artificial skin.
E) with d) composite made again through cutting, packing, irradiation sterilization, can make the chitin artificial skin.
The fineness of described chitin fiber is 1.0D～3.0D, and length is 25-60mm.
Described chitin fiber can also adopt its derivant to be deacetyl chitin fiber (chitosan fiber) or to take off the butyryl chitin fiber and replace.
Described antibiotic can adopt gentamycin, neomycin powder etc.
Another object of the present invention is achieved in that provides a kind of artificial skin.Described artificial skin be with chitin fiber (1) be raw material through combing,, antibiotic treatment compound with light water thorn water distribution thorn, compound with waterproof ventilated membrane, cut the chitin multi-layer compound structure material that working procedure processing such as packing, irradiation sterilization form.Since the intermediate layer of this product be compounded with high liquid-absorbing can fiber (2), than monolayer chitin spun laced fabric, liquid holdup is more, can prevent from effectively therefore that liquid from crossing to overflow and have tangible moisture-keeping functions.Outermost layer is compounded with waterproof ventilated membrane (4), can effectively control the excessive vaporization of wound body fluid and cause the incrustation and adhesion.For the larger area skin trauma, in order further to improve the antimicrobial and anti-inflammation efficacy of artificial skin, this product has passed through antibiotic treatment in process of production.Because chitin is biodegradable to be glucosamine, absorbed by human body, therefore product not only has premium properties such as breathability, the drapability of high-absorbable, appropriateness be good, but also have good biocompatibility, can produce the hydrophilic gel material in the wound, prevent that antibacterial from passing through, antibacterial, antiinflammatory, effect such as protect from infection.Artificial skin of the present invention can also adsorb the serum proteins that wound surface oozes out, and stimulates the body cell growth, has hemostasis, analgesic effect, can also control the evaporation of wound fluid, keeps the wetting state of appropriateness, promotes wound healing.Be specially adapted to aspects such as extensive wound, burn, scald and artificial skin-grafting.
Appended drawings is represented the structural representation of a kind of artificial skin provided by the invention.
The invention will be further described below in conjunction with preferred embodiment of the present invention for the specific embodiment.
Embodiment 1
The viscose staple fibre that at first with specification is 1.5D * 38mm becomes net, operation such as dries, batches and make 45g/m by mixing, combing, jet
2Spun-laced nonwoven fabric.Then chitosan fiber is fed intake, through weighing, mixed cotton, shredding, mechanical carding, becoming net in a jumble, form the fibre web with certain brute force and density, Unit Weight is 40g/m
2, by four sprinkler heads in jet I district the chitin fibre web is carried out tentatively fixedly, pressure is respectively 1.0bar (prewetting), 30bar, 45bar and 55bar.Again with the 45g/m that has made
2Spun-laced nonwoven fabric be incorporated in the lump after superimposed and carry out further fixedly under five sprinkler heads in jet II district, pressure is respectively 10bar, 40bar, 70bar, 100bar and 90bar.(requiring the amount on the cloth is 2200mg/m by the infiltration of gentamycin dipper again
2), oven dry, reel, to carry out coating by hot melt compounding machine and breathing waterproof film compound in unwinding then, selects polyethylene glue (3) coating for use, coating amount 5～8g/m
2The breathing waterproof film specification is 14g/m
2, MVTR value (moisture-vapor transmission) is 5500.Again through cutting, packing, after cobalt-60 irradiation sterilization process.
Embodiment 2 produces deacetyl chitin fiber by the method that embodiment 1 provides.
The netted fine structure material of chitin fiber that adopts embodiment 1 to 3 described method to make is particularly suitable as artificial skin and uses.
Claims (5)
1, a kind of manufacture method of artificial skin is characterized in that following steps:
A) viscose staple fibre or cotton short fiber etc. is had high liquid-absorbing can general fibre make the spun-laced nonwoven fabric of certain grammes per square metre according to common water jet process.
B) with chitin fiber by the carding machine carding, it is tentatively fixed to utilize high-pressure spray that fibre web is carried out by jet I district then, again with debatching under the spun laced fabric that makes of a) step compound, through jet II district mesohigh jet carry out fixed, put in order.
C) with b) the fixed multi-layer compound structure material that forms of step fully soaks into by the antibiolics groove, again drying, batch and make coiled material.
D) with c) coiled material debatching that step makes, on the hot melt compounding machine, carry out compound with breathing waterproof film.Adopt the point-like contact bonding, contact area accounts for the 10-30% of whole area coverage, can effectively control the evaporation capacity and the Air permenbility of artificial skin.
E) with d) composite made again through cutting, packing, irradiation sterilization, can make the chitin artificial skin.
The fineness of described chitin fiber is 1.0D～3.0D, and length is 25-60mm.
Described chitin fiber can also adopt its derivant to be deacetyl chitin fiber (chitosan fiber) or to take off the butyryl chitin fiber and replace.
Described antibiotic can adopt gentamycin, neomycin powder etc.
2, a kind of artificial skin made from the described method of claim 1 is characterized in that:
Described artificial skin is be raw material with the chitin fiber through combing,, antibiotic treatment compound with light water thorn water distribution thorn, compound with waterproof ventilated membrane, cut operations such as packing, irradiation sterilization and put the chitin multi-layer compound structure material that forms in order.Since the bottom of this product be compounded with high liquid-absorbing can fiber, than monolayer chitin spun laced fabric, liquid holdup is more, can prevent from therefore that liquid from crossing to overflow and have moisture-keeping functions.For the larger area skin trauma, in order further to improve the antimicrobial and anti-inflammation efficacy of artificial skin, this product has passed through antibiotic treatment in process of production.Because chitin is biodegradable to be glucosamine, absorbed by human body, therefore have good biological activity and biocompatibility.
3, artificial skin according to claim 2 is characterized in that: product has good biocompatibility, can produce the hydrophilic gel material in the wound, prevents that antibacterial from passing through, effect such as suppress antibacterial, antiinflammatory, protect from infection.Artificial skin of the present invention can also adsorb the serum proteins that wound surface oozes out, and stimulates the body cell growth, has hemostasis, analgesic effect, can also control the evaporation of wound fluid, keeps the wetting state of wound, promotes wound healing.
4, the described artificial skin of claim 2 is specially adapted to extensive wound, burn, scald.
5, the described artificial skin of claim 2 is specially adapted to aspects such as artificial skin-grafting.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 02128433 CN1219554C (en) | 2002-07-31 | 2002-07-31 | Artificial skin and producing method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 02128433 CN1219554C (en) | 2002-07-31 | 2002-07-31 | Artificial skin and producing method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1471979A true CN1471979A (en) | 2004-02-04 |
| CN1219554C CN1219554C (en) | 2005-09-21 |
Family
ID=34143727
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 02128433 Expired - Lifetime CN1219554C (en) | 2002-07-31 | 2002-07-31 | Artificial skin and producing method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1219554C (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109276749A (en) * | 2017-07-20 | 2019-01-29 | 泰陞国际科技股份有限公司 | Anti- adhesion dressing and its manufacturing method |
| CN109276746A (en) * | 2017-07-20 | 2019-01-29 | 泰陞国际科技股份有限公司 | Except scar patch and its manufacturing method |
-
2002
- 2002-07-31 CN CN 02128433 patent/CN1219554C/en not_active Expired - Lifetime
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109276749A (en) * | 2017-07-20 | 2019-01-29 | 泰陞国际科技股份有限公司 | Anti- adhesion dressing and its manufacturing method |
| CN109276746A (en) * | 2017-07-20 | 2019-01-29 | 泰陞国际科技股份有限公司 | Except scar patch and its manufacturing method |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1219554C (en) | 2005-09-21 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CA2760792C (en) | Compositions comprising honey and a super- absorbent material | |
| EP4265280A2 (en) | Antimicrobial dressing | |
| CN104027832B (en) | Absorbing material | |
| CN104189942A (en) | Antibacterial wound dressing and preparation method thereof | |
| CN103550817B (en) | A kind of Bacterial cellulose/shitosan composite sponge dressing and preparation method thereof | |
| CN107469131A (en) | A kind of calcium alginate biology based composite dressing for medical use and preparation method thereof | |
| CN104383585B (en) | A kind of three-dimensional manometer composite adhesive bandage and preparation and application thereof | |
| CN107106722A (en) | Wound dressing apparatus | |
| CN113413267A (en) | High-absorptivity wound dressing | |
| BR112013010899B1 (en) | DRESSING WITH A BIOCELLULOSE LAYER WITH BACTERIA ADSORBENT FINISH | |
| CN106983902A (en) | A kind of novel nano composite wound bandage | |
| CN109248333A (en) | A kind of medical dressing and its preparation method and application of antibacterial wound healing | |
| CN110787317A (en) | Department of anesthesia uses hemostatic sponge | |
| CN107296975A (en) | A kind of antibacterial anti hemorrhagic based composite dressing for medical use and preparation method thereof | |
| US20170197006A1 (en) | Honey-based foam compositions | |
| GB2435425A (en) | Wound healing system and dressing containing sodium alginate and/or calcium alginate powder | |
| AU2021105727A4 (en) | A method of preparation of Silk Fibroins coated with Hybrid chitosan-ZnO nanoparticles for wound dressing. | |
| Gupta et al. | Textile materials and structures for wound care products | |
| CN1298972A (en) | Hydro-entangled non-woven chitin fibre cloth and its production method | |
| CN101019793A (en) | Interactive medical wet dressing and its prepn and application | |
| CN1219554C (en) | Artificial skin and producing method thereof | |
| CN112981706A (en) | Antibacterial flame-retardant alginate fiber spunlace non-woven fabric and manufacturing method thereof | |
| GB2432790A (en) | A wound dressing with active ingredients | |
| CN117065075A (en) | Nanofiber antibacterial dressing and preparation method thereof | |
| CN111249515A (en) | Biomedical dressing with antibacterial, anti-inflammatory and wound healing promoting functions and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CX01 | Expiry of patent term |
Granted publication date: 20050921 |
|
| CX01 | Expiry of patent term |