CN1462624A - Medicine compsn. for antagonizing poison-side effect caused by psychotropic drug - Google Patents
Medicine compsn. for antagonizing poison-side effect caused by psychotropic drug Download PDFInfo
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- CN1462624A CN1462624A CN02121074A CN02121074A CN1462624A CN 1462624 A CN1462624 A CN 1462624A CN 02121074 A CN02121074 A CN 02121074A CN 02121074 A CN02121074 A CN 02121074A CN 1462624 A CN1462624 A CN 1462624A
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Abstract
A Chinese medicine as the mate of antipsychotics for lowering their toxic by-effect and improving the tolerance of patient is prepared from 17 Chinese-medicinal materials including liquorice root, American ginseng, earthworm, wolfberry fruit, etc.
Description
The present invention relates to a kind of pharmaceutical composition, specifically a kind of combine by vegetable Chinese herbal medicine, pharmaceutical composition that can antagonism psychotropic drugs toxic and side effects.
Psychosis is a class common disease of being lacked of proper care by the cerebral function that a variety of causes causes.Chang Yong medicine has clinically: 1, antipsychotic drug, as chlorpromazine, perphenazine, clozapine etc.; 2, antidepressant drug is as amitriptyline, imipramine, the equality of worrying too much; 3, antimanic drug is as lithium carbonate etc.; 4, anxiolytic drugs is as stable, chlomezanone, miltown etc.Its effective dose curve of these psychotropic drugs and the toxicity curve of self are proportionate, and promptly when medicine reached effective control clinical symptoms dosage, its toxicity also increased thereupon.Because psychosis has characteristics such as the tediously long and easy recurrence of the course of disease, so must adhere to taking medicine for a long time when clinical treatment being controlled.Routine administration amount as chlorpromazine is generally 400-600mg/ day, reaches 600-800mg/ day when the state of an illness is heavier, need take the several months continuously or just can come into force more for a long time.When symptom disappearance or complete obiteration substantially, insight recovers substantially or recover fully after, also need take the chlorpromazine of former therapeutic dose 1/4-1/3 and keep 3-5 or more of a specified duration.In taking the process that psychotropic drugs treats, because the existence of poisonous side effect of medicine has not only brought very big misery to the patient, and brought a lot of difficulties to treatment.Clinical manifestation is: some patient has born and has made us insufferable side effect, and some patient produces some serious medicine source sexually transmitted disease (STD) diseases.Its result or be to be reluctant or to refuse to take medicine because of the patient can't stand causes treatment to interrupt; Be the drug withdrawal of having to, turn to emergent management side effect; Be because of side effect can't increase dose again, cause dose not in place, clinical efficacy is had a greatly reduced quality.
The toxic and side effects that psychotropic drugs causes roughly has the reaction of following several respects: 1, nervous system, as The extrapyramidal symptoms, epileptic outbreak; 2, spiritual aspect is as drug induced depression, medicine source property anxiety, cognitive dysfunction; 3, other aspects, as liver function injury, autonomic nervous dysfunction, endocrine disturbance, until the sudden death etc.
Though various countries the world of medicine is being devoted to study good effect, the little psychotropic drugs of side effect always, does not still have the psychotropic drugs of being free from side effects at present and emerge.Therefore people transfer the medicine of development antagonism psychotropic drugs side effect.Through research for many years, though developed several agonist drugs, the use of these medicines still has a lot of limitations, even will bear very big risk.Can slow down the symptom of The extrapyramidal symptoms if any a kind of Western medicine that is named as trihexyphenidyl (benzhexol hydrochloride), but this medicine itself also has very strong side effect, and this side effect is promptly followed the patient lifelong, and is pasted medical help in case occur.These agonist drugs in addition, every kind general also just works at a certain toxic and side effects of psychotropic drugs, and does not have a kind of the general effectively agonist drug of the multiple toxic and side effects of psychotropic drugs to be come out.Therefore the side effect of psychotropic drugs is a still unsolved difficult problem in the current psychosis medical field.Though record a few treatment side's medicine in China's Chinese medicine document, do not treat the achievement in research of psychotropic drugs toxic and side effects aspect, so Chinese medicine research also still belongs to blank in this field at mental sickness.
Purpose of the present invention just provide a kind of based on Chinese medicine, the effective pharmaceutical composition of the multiple psychotropic drugs toxic and side effects of antagonism.
The object of the present invention is achieved like this: select Radix Glycyrrhizae 10-20 part (weight portion, as follows) for use, Radix Scrophulariae 10-20 part, Rhizoma Anemarrhenae 6-18 part, Radix Panacis Quinquefolii 3-10 part, Pheretima 5-15 part, Semen Ziziphi Spinosae 10-60 part, Rhizoma Acori Graminei 5-15 part, Flos Albiziae 10-20 part, Magnetitum 10-30 part, Semen Platycladi 10-20 part, Arisaema Cum Bile 5-15 part, Concha Ostreae 10-30 part, Poria (processed with Cinnabaris) 10-20 part, Radix Ophiopogonis 10-20 part, Fructus Lycii 10-20 part, Placenta Hominis 1.5-3 part, Rhizoma Cyperi 5-15 part is mixed with pharmaceutical composition.
Medicine of the present invention can be prepared into various peroral dosage forms such as tablet, pill, capsule, decoction, electuary or oral liquid.
Chinese medicine is the treasure-house of a greatness, and the side effect of Chinese medicine own is minimum, and has incomparable, the good function of detoxification of Western medicine.The traditional Chinese medical science thinks that the toxic action of psychotropic drugs causes in the human body asthenic fire and contains, stagnated QI transforming into fire, and damp is stagnated, and injures lung yin, YIN-fluid being insufficient, the kidney qi degradation, it is not normal to gasify, and causes interior-heat caused by deficiency of YIN.So the Therapeutic Principle should be auxilliary with tranquilizing by nourishing the heart, soothing liver-QI for relieving depression, diuretic life spleen, reinforcing the kidney and supporting YANG based on detoxifcation and nourishing YIN to lower pathogenic fire, helps to regulate the flow of vital energy, to have one's ideas straightened out again, and takes into account the effect of setting upright to reach.The present invention is based on modern pharmacological research, in conjunction with motherland's theory of medicine and two more than ten years Chinese and western medicine psychosis clinical treatment experience, the toxic and side effects that causes at psychotropic drugs, dialectical executing controlled, select for use and have nourishing YIN to lower pathogenic fire, detoxifcation is had one's ideas straightened out, the vegetable Chinese herbal medicine organic assembling of mind tranquilizing and the heart calming, makes the good synergism of generation between the each component, the multiple toxic and side effects of the antagonism psychotropic drugs of making a concerted effort.The present invention is with Radix Scrophulariae and the Rhizoma Anemarrhenae key medicine as nourishing YIN to lower pathogenic fire, and reuse Radix Glycyrrhizae with in and toxicity, again through multiple compatibility of drugs, thereby reach the therapeutic effect that can suppress and alleviate psychotropic drugs causes surplus in the of 30 kind of toxic and side effects.The present invention and psychotropic drugs are used simultaneously, the effect of Western medicine and advantage are manifested and bring into play, obtain curative effect preferably; Can alleviate patient's misery and toxic and side effects reaction again, increase the compliance and the toleration of clothes Western medicine, strengthen patient and family members' treatment confidence.Thereby help to improve psychotic cure rate, reduce relapse rate.
The preparation method of decoction of the present invention is: take by weighing each component by the proportioning in the prescription of the present invention, wherein Concha Ostreae decocts earlier, and Radix Panacis Quinquefolii slow fire boils in addition, Semen Ziziphi Spinosae is fried the back and is merged with all the other components, and Placenta Hominis is ground into powder, and all the other components become decoction pieces, soaked 30-40 minute, decocted 0.5-1 hour, filter, after leaving and taking filtrate, add water again and repeated to decoct 0.5-1 hour, filter, twice filtrate merges, be sub-packed in the 100ml bottle high pressure steam sterilization.
The usage and dosage of decoction of the present invention is 200ml every day, at twice the empty stomach decoction being taken warmly.
Medicine of the present invention is applicable to that treatment produces the patient of various toxic and side effects because of taking psychotropic drugs.
In order further to strengthen the antagonism of the present invention, can on the basis of principal agent, increase some medicines again to a certain badness reaction of psychotropic drugs.As:
On the basis of principal agent, increase Rhizoma Gastrodiae 3-10 part, Scorpio 0.6-1 part, Scolopendra 0.6-1 part, Calculus Bovis 0.2-0.5 part, Bombyx Batryticatus 1-1.5 part, Fructus Chaenomelis 6-12 part, Bulbus Fritillariae Thunbergii 1-1.5 part.Because these medications have the effect of removing muscle spasm,, go for having the patient of psychotropic drugs side effect such as serious The extrapyramidal symptoms and tardive dyskinesia therefore with after principal agent combines.
On the basis of principal agent, increase Radix Polygalae 3-10 part, Herba Menthae 2-10 part, Radix Bupleuri 3-10 part, Rhizoma Atractylodis Macrocephalae 5-15 part, Radix Linderae 3-10 part, Radix Paeoniae Alba 5-30 part, Fructus Tritici Levis 30-60 part.Because these medications have the effect of multiple amine (5-HT) of the 5-hydroxyl that improves in the brain and norepinephrine (NT) content, so, go for having the patient of serious psychotropic drugs side effect such as drug induced depression with after principal agent combines.
On the basis of principal agent, increase Margarita 0.3-1 part, Bulbus Allii Macrostemonis 5-10 part, Medulla Junci 1.5-2.5 part, Colla Corii Asini 5-10 part, Fructus Tritici Levis 30-60 part, Radix Salviae Miltiorrhizae 5-15 part.Because these medications have the effect of calming the nerves,, go for having the patient of serious psychotropic drugs side effect such as medicine source property anxiety therefore with after principal agent combines.
On the basis of principal agent, increase Arillus Longan 10-30 part, Radix Polygalae 3-10 part, Carapax et Plastrum Testudinis 10-30 part, Dens Draconis 10-30 part.Because these medications have the transmission of quickening brain cell, the effect that improves memory function,, go for having the patient of serious psychotropic drugs side effect such as cognitive dysfunction therefore with after principal agent combines.
On the basis of principal agent, increase Caulis Spatholobi 10-30 part, Squama Manis 1-1.5 part, Radix Polygoni Multiflori 10-30 part, Colla Corii Asini 5-10 part, wine Radix Rehmanniae 10-30 part.Because these medications have stimulates hemopoietic function of bone marrow, increase granulocytic effect,, go for having the patient of serious psychotropic drugs side effect such as granulocytopenia therefore with after principal agent combines.
On the basis of principal agent, increase Radix Angelicae Sinensis 5-10 part, Radix Paeoniae Alba 5-30 part, Radix Astragali 10-60 part, Bulbus Fritillariae Cirrhosae 1-1.5 part, Flos Magnoliae Officinalis 3-10 part, Fructus Schisandrae Chinensis 1-3 part, Fructus Corni 5-30 part, Radix Aucklandiae 3-10 part, Fructus Tritici Levis 30-60 part.Because these medications have and stablize sympathetic and parasympathetic effect, so, go for having the patient of serious side effect such as medicine source property neurological disorders with after principal agent combines.
Effect of the present invention has obtained checking by the clinical observation of 216 routine systems.
The verification method of curative effect of the present invention is:
The patient reaches therapeutic dose for taking psychotropic drugs, and poisonous side effect of medicine occurs, and adopts " side reaction scale (TESS) " to be assessed as the side reaction order of severity moderate and above person thereof.
Adopt single at random blind method to be divided into experimental group and each 108 example of matched group, experimental group is taken medicine of the present invention (embodiment 1 is seen in concrete preparation), and matched group is not taken any chemical agonist drug.
The clinical disease diagnosis standard:
According to Chinese psychosis classification schemes and diagnostic criteria second edition (CCMDII) (Shen, People's Health Publisher fishing Estate chief editor " psychiatry ")
The clinical development standard is:
1, adopts side reaction scale (TESS).
2, to be divided into be four classification standards to TESS, promptly extremely light, slight, moderate, severe.
When 3, evaluated at the end all around, classification standard of every reduction was that effectively reducing by two classification standards is produce effects, reduced the Three Estate standard for alleviating.
Experimental result sees Table 1, table 2.
Table 1: experimental group experiment statistics form
Table 2: two groups of influences to psychotropic drugs dosage and treatment
Above experimental result shows that medicine of the present invention is the multiple toxic and side effects of antagonism psychotropic drugs effectively.The present invention and psychotropic drugs use together, have also strengthened toleration and the compliance of patient to psychotropic drugs effectively.
Embodiment 1:
Take by weighing Radix Glycyrrhizae 20kg, Radix Scrophulariae 20kg, Rhizoma Anemarrhenae 6kg, Radix Panacis Quinquefolii 3kg, Pheretima 15kg, Semen Ziziphi Spinosae (stir-fry) 10kg, Rhizoma Acori Graminei 15kg, Flos Albiziae 10kg, Magnetitum 30kg, Semen Platycladi 20kg, Arisaema Cum Bile 15kg, Concha Ostreae 10kg, Poria (processed with Cinnabaris) 10kg, Radix Ophiopogonis 10kg, Fructus Lycii 10kg, Placenta Hominis (grinding into powder) 1.5kg, Rhizoma Cyperi 5kg.
The Radix Panacis Quinquefolii slow fire boiling is standby after 20 minutes, add water in the lump with all the other components after Concha Ostreae was decocted first 30 minutes, soaked 30 minutes, decocted 1 hour, to filter, filtrate for later use adds water again and continues to decoct 1 hour, filters.Twice filtrate merges, and adds american ginseng liquid and stirs evenly, and is packed as the bottled decoction of 100ml, high pressure steam sterilization.
The preparation method of embodiment 2-7 is substantially the same manner as Example 1, is that composition, proportioning are different, but all has effect of the present invention.Need to prove that different embodiment has more significant curative effect to the caused corresponding toxic and side effects of psychotropic drugs.
Table 3: embodiment 2-7
(connecing table 3)
Claims (7)
1, a kind of pharmaceutical composition of composition for antagonizing poison-side effect caused by psychotropic is characterized in that it is to make by containing the following weight proportion raw material:
Radix Glycyrrhizae 10-20 part, Radix Scrophulariae 10-20 part, Rhizoma Anemarrhenae 6-18 part, Radix Panacis Quinquefolii 3-10 part, Pheretima 5-15 part, Semen Ziziphi Spinosae 10-60 part, Rhizoma Acori Graminei 5-15 part, Flos Albiziae 10-20 part, Magnetitum 10-30 part, Semen Platycladi 10-20 part, Arisaema Cum Bile 5-15 part, Concha Ostreae 10-30 part, Poria (processed with Cinnabaris) 10-20 part, Radix Ophiopogonis 10-20 part, Fructus Lycii 10-20 part, Placenta Hominis 1.5-3 part, Rhizoma Cyperi 5-15 part.
2, the pharmaceutical composition of composition for antagonizing poison-side effect caused by psychotropic according to claim 1 is characterized in that said raw material also has: Rhizoma Gastrodiae 3-10 part, Scorpio 0.6-1 part; Scolopendra 0.6-1 part, Calculus Bovis 0.2-0.5 part, Bombyx Batryticatus 1-1.5 part; Fructus Chaenomelis 6-12 part, Bulbus Fritillariae Thunbergii 1-1.5 part.
3, the pharmaceutical composition of composition for antagonizing poison-side effect caused by psychotropic according to claim 1 is characterized in that said raw material also has: Radix Polygalae 3-10 part, Herba Menthae 2-10 part, Radix Bupleuri 3-10 part, Rhizoma Atractylodis Macrocephalae 5-15 part, Radix Linderae 3-10 part, Radix Paeoniae Alba 5-30 part, Fructus Tritici Levis 30-60 part.
4, the pharmaceutical composition of composition for antagonizing poison-side effect caused by psychotropic according to claim 1 is characterized in that said raw material also has: Margarita 0.3-1 part, Bulbus Allii Macrostemonis 5-10 part, Medulla Junci 1.5-2.5 part, Colla Corii Asini 5-10 part, Fructus Tritici Levis 30-60 part, Radix Salviae Miltiorrhizae 5-15 part.
5, the pharmaceutical composition of composition for antagonizing poison-side effect caused by psychotropic according to claim 1 is characterized in that said raw material also has: Arillus Longan 10-30 part, Radix Polygalae 3-10 part, Carapax et Plastrum Testudinis 10-30 part, Dens Draconis 10-30 part.
6, the pharmaceutical composition of composition for antagonizing poison-side effect caused by psychotropic according to claim 1 is characterized in that said raw material also has: Caulis Spatholobi 10-30 part, Squama Manis 1-1.5 part, Radix Polygoni Multiflori 10-30 part, Colla Corii Asini 5-10 part, wine Radix Rehmanniae 10-30 part.
7, the pharmaceutical composition of composition for antagonizing poison-side effect caused by psychotropic according to claim 1, it is characterized in that said raw material also has: Radix Angelicae Sinensis 5-10 part, Radix Paeoniae Alba 5-30 part, Radix Astragali 10-60 part, Bulbus Fritillariae Cirrhosae 1-1.5 part, Flos Magnoliae Officinalis 3-10 part, Fructus Schisandrae Chinensis 1-3 part, Fructus Corni 5-30 part, Radix Aucklandiae 3-10 part, Fructus Tritici Levis 30-60 part.
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Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN100352447C (en) * | 2005-01-27 | 2007-12-05 | 河南中医学院 | Anxiolytic matter extracted from preparata |
| CN102225186A (en) * | 2011-06-27 | 2011-10-26 | 史建钢 | Medicine for treating neurosis and preparation method thereof |
| CN102698094A (en) * | 2012-06-18 | 2012-10-03 | 田冬梅 | Medicament for treating female depression |
| CN102908587A (en) * | 2012-10-29 | 2013-02-06 | 钟思冰 | Brain-building intelligence-reinforcing pill for treating brain exhaustion psychosis |
| CN103520646A (en) * | 2013-10-21 | 2014-01-22 | 广州博济医药生物技术股份有限公司 | Chinese medicine composition for treating depression and preparation method of Chinese medicine composition |
| CN103623095A (en) * | 2013-11-26 | 2014-03-12 | 任新年 | Traditional Chinese medicine for treating anxiety disorder and preparation method thereof |
| EP2691102A4 (en) * | 2011-03-29 | 2014-11-05 | Viromed Co Ltd | Herbal compositions for treating neurological diseases and improving memory impairment |
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| CN101642510B (en) * | 2009-08-27 | 2012-02-22 | 石芳 | Traditional Chinese medicine composite for treating serious vesania and preparation method thereof |
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- 2002-05-31 CN CNB021210748A patent/CN1242780C/en not_active Expired - Fee Related
Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100352447C (en) * | 2005-01-27 | 2007-12-05 | 河南中医学院 | Anxiolytic matter extracted from preparata |
| EP2691102A4 (en) * | 2011-03-29 | 2014-11-05 | Viromed Co Ltd | Herbal compositions for treating neurological diseases and improving memory impairment |
| US10058583B2 (en) | 2011-03-29 | 2018-08-28 | Viromed Co., Ltd. | Herbal compositions for treating neurological diseases and improving memory impairment |
| CN102225186A (en) * | 2011-06-27 | 2011-10-26 | 史建钢 | Medicine for treating neurosis and preparation method thereof |
| CN102698094A (en) * | 2012-06-18 | 2012-10-03 | 田冬梅 | Medicament for treating female depression |
| CN102908587A (en) * | 2012-10-29 | 2013-02-06 | 钟思冰 | Brain-building intelligence-reinforcing pill for treating brain exhaustion psychosis |
| CN103520646A (en) * | 2013-10-21 | 2014-01-22 | 广州博济医药生物技术股份有限公司 | Chinese medicine composition for treating depression and preparation method of Chinese medicine composition |
| CN103520646B (en) * | 2013-10-21 | 2015-05-13 | 广州博济医药生物技术股份有限公司 | Chinese medicine composition for treating depression and preparation method of Chinese medicine composition |
| CN103623095A (en) * | 2013-11-26 | 2014-03-12 | 任新年 | Traditional Chinese medicine for treating anxiety disorder and preparation method thereof |
| CN105935422A (en) * | 2016-05-10 | 2016-09-14 | 浙江省中医院 | Traditional Chinese medicinal composition and application thereof in preparation of blood lead reducing medicines |
| CN105935422B (en) * | 2016-05-10 | 2020-01-14 | 浙江省中医院 | Traditional Chinese medicine composition and application thereof in preparation of blood lead reducing medicine |
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| CN1242780C (en) | 2006-02-22 |
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