CN1456168A - Anti-fatigue formulating prescription - Google Patents
Anti-fatigue formulating prescription Download PDFInfo
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- CN1456168A CN1456168A CN03120760.XA CN03120760A CN1456168A CN 1456168 A CN1456168 A CN 1456168A CN 03120760 A CN03120760 A CN 03120760A CN 1456168 A CN1456168 A CN 1456168A
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- radix puerariae
- prescription
- extract
- arginine
- puerariae extract
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- Medicines Containing Plant Substances (AREA)
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Abstract
An antifatigue medicine for increasing sports endurance and improving respiratory function is prepared from the common flavone of pueraria root and L-arginine in ratio of (0.5-1.5):1.
Description
The present invention relates to a kind of prescription, its characteristics are that it extracts two kinds of raw materials of composition by L-arginine and Radix Puerariae or Radix Puerariae and form, its ratio is 0.5～1: 2 (the L-arginine: Radix Puerariae or Radix Puerariae extract composition), this prescription is by improving respiratory function, improves the scientific composition of anti-anoxia ability and the effect bringing into play anti-fatigue effect, improve exercise tolerance.
Biomedical theoretical according to free radical, under the normal physiological conditions, the generation and the removing of free radical are in the dynamic equilibrium in the body, and acute exercise then can be destroyed this balance, causes the accumulation of free radical.Davis (1982) at first finds that with the electron spin resonance technical research rat is carrying out submaximal exercise when power exhausts on the treadmill, and the generation rate of free radical increases 2-3 doubly.Studies show that, the free radical level that acute exercise causes increases and the lipid peroxidation reinforcement can cause forfeiture of biomembrane integrity and damages such as sarcolemma and mitochondrial membrane, thereby damage mitochondrion and cause a series of cellular metabolism disorders, infringement of cell popularity and pathological change, finally cause the muscular work ability drop, sports fatigue occurs.On the other hand, according to biological metabolism mechanism, two kinds of metabolism are arranged, i.e. aerobic metabolism and anaerobic metabolism in the organism.When high-intensity exercise, because body is in anaerobic condition to a certain degree, anaerobic metabolism accounts for certain proportion, it is the major reason that causes sports fatigue that a large amount of free radicals that produce during anaerobic metabolism and lactic acid cause the imbalance of organismic internal environment stable state, utilize the ability of oxygen and the oxygen delivery capacity of cardiovascular system so improve, aerobic capacity is strengthened, reduce the accumulation of lactic acid in the body, significant with the stable state of environment acid-base balance in keeping.But up to now, can specific aim improve the body anaerobic environment, improve anti-fatigue ability, safely and effectively the functional exercise tonic still seldom, and some have the steroid medicine that improves endurance and have very strong side effect.Therefore, should from natural food or Chinese herbal medicine, choose effective ingredient, select rational medicament composing prescription, be processed into preparation easily, the performance expected effect according to their pharmacology characteristics.
The objective of the invention is for a kind of product that improves exercise tolerance that has is provided.It can be used for athlete, soldier and ordinary people.It mainly is the pharmacology characteristics according to L-arginine and Chinese medicine ingredients Radix Puerariae total flavones, studies show that Radix Puerariae total flavones is a kind of good antioxidants, can effectively remove multiple free radical, thereby blocking-up cell membrane lipid peroxidization alleviates the biomembranous infringement of radical pair, the structures shape of Radix Puerariae total flavones it have antiinflammatory, antifatigue effect.The L-arginine is precursor or the donor that produces N0, in recent years studies show that it may play diastole air flue and cardiovascular smooth muscle by improving endogenous NO content, increases vital capacity, thereby improves the ability of anti-body hypoxia-bearing.This prescription is by improving respiratory function and blood circulation function, improve the blood oxidation resistance, reducing acidic metabolite and produce and accumulate, the release of desmoenzyme (CK, LDH, GPT, GOT), improve the blood alkaline phosphatase activities and make it to help substrate level phosphorylation, promotes aerobic metabolism and protection cell membrane and reaches the purpose that improves exercise tolerance.
The present invention is achieved in that with the free radical biomedicine be guidance, utilize the modern science extractive technique from natural plants, to extract, screen by a large amount of, and, Radix Puerariae extract and L-arginine mixed by a certain percentage and make multiple dosage forms such as capsule, electuary, oral liquid, tablet and beverage the scientific analysis of existing achievement in research.
The present invention announces the extraction process of Radix Puerariae total flavones: Radix Puerariae decoction pieces, coarse granule or powder extracted 1-3 hour through 70-95% ethanol reduced-pressure backflow; filter; repeat 3 times; after reclaiming ethanol; the adding distil water dilution; the reuse ethyl acetate extraction promptly gets puerarin content and is 39.8% Radix Puerariae extract after the recovery.
Claims (4)
1. tired prescription of the novel anti of forming by Radix Puerariae extract and L-arginine, it is characterized in that it by Radix Puerariae extract and L-arginine with 0.5～1.5: 1 ratio is formed compound recipe.
2. be a kind of product that processes from strand by Radix Puerariae extract according to described this product of claim 1; this extract extracting method follows these steps to carry out: with Radix Puerariae decoction pieces, coarse granule or powder is raw material; at first use 70～95% ethanol extractions, reduced-pressure backflow extracted 1～4 hour, filtered; repeat 1～3 time; after reclaiming ethanol, add distilled water diluting, the reuse ethyl acetate extracts; reclaim ethyl acetate, promptly get the Radix Puerariae extract that puerarin content is 30-40% after the drying.
3. prescription according to claim 1, its functional character are that it has the respiratory function of improvement, improve the effect of anti-anoxia ability, resisting fatigue, raising exercise tolerance.
4. prescription according to claim 1 can become multiple dosage forms such as capsule, electuary, oral liquid, tablet and functional drinks by last art processes.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB03120760XA CN100455292C (en) | 2003-03-19 | 2003-03-19 | Anti-fatigue formulating prescription |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB03120760XA CN100455292C (en) | 2003-03-19 | 2003-03-19 | Anti-fatigue formulating prescription |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1456168A true CN1456168A (en) | 2003-11-19 |
| CN100455292C CN100455292C (en) | 2009-01-28 |
Family
ID=29411565
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB03120760XA Expired - Fee Related CN100455292C (en) | 2003-03-19 | 2003-03-19 | Anti-fatigue formulating prescription |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN100455292C (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101336723B (en) * | 2008-07-30 | 2012-07-18 | 广州蓝钥匙海洋生物工程有限公司 | Health food for relieving physical fatigue |
-
2003
- 2003-03-19 CN CNB03120760XA patent/CN100455292C/en not_active Expired - Fee Related
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101336723B (en) * | 2008-07-30 | 2012-07-18 | 广州蓝钥匙海洋生物工程有限公司 | Health food for relieving physical fatigue |
Also Published As
| Publication number | Publication date |
|---|---|
| CN100455292C (en) | 2009-01-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| ASS | Succession or assignment of patent right |
Free format text: FORMER OWNER: SONG SHUZHEN Effective date: 20030708 Owner name: GENERAL HOSPITAL OF P.L.A. Free format text: FORMER OWNER: TIAN YAPING |
|
| C41 | Transfer of patent application or patent right or utility model | ||
| TA01 | Transfer of patent application right |
Effective date of registration: 20030708 Address after: 100853, Fuxing Road, Beijing, No. 16, building 4, No. 28, gate 302 Applicant after: General Hospital of Chinese PLA Address before: 100853, Fuxing Road, Beijing, No. 16, building 4, No. 28, gate 302 Applicant before: Tian Yaping Co-applicant before: Song Shuzhen |
|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C17 | Cessation of patent right | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20090128 Termination date: 20130319 |