CN1454631A - Schefflera (Hantaoye) soft capsule and preparing method thereof - Google Patents

Schefflera (Hantaoye) soft capsule and preparing method thereof Download PDF

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Publication number
CN1454631A
CN1454631A CN 03117241 CN03117241A CN1454631A CN 1454631 A CN1454631 A CN 1454631A CN 03117241 CN03117241 CN 03117241 CN 03117241 A CN03117241 A CN 03117241A CN 1454631 A CN1454631 A CN 1454631A
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soft capsule
schefflerae arboricolae
radix schefflerae
extract
cera flava
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CN1255131C (en
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张乐陵
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Guizhou Sanli Pharmaceutical Co ltd
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GUIZHOU SANLI PHARMACY Ltd
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Abstract

The invention is a kind of caulis sohefflerae K wangsiensis soft capsule and the manufacturing method. The caulis sohefflerae K wangsiensis is extracted by water or alcohol, the extracted material is blended with edible oil, beeswax. They are filled, and compressed into capsules. Compared with current technology, the construction and manufacturing method of the invention are simple. The process is easy to be controlled, the medicine quality can be guaranteed. The invention has prominent effect on trigeminal neuralgia, migraine, sciatica, rheumatoid arthritis.

Description

Radix Schefflerae Arboricolae soft capsule and preparation method thereof
Technical field: the present invention is a kind of Radix Schefflerae Arboricolae soft capsule and preparation method thereof, belongs to technical field of Chinese medicines.
Technical background: is the practice of the long-term life of China working people with Radix Schefflerae Arboricolae as the medicine for the treatment of physical distress, generally is made in the prior art to tablet supplies the patient to take; But it needs to add some auxiliary materials in manufacturing process because on technology, such as: need to add adhesive, find that so in actual use its preparation stability is poor especially, the easy moisture absorption of medicine, go mouldy, sliver and influenced the quality of medicine; Because this tablet is a solids, the coarse granule after the oral disintegrate needs molten diffusing process in addition, and the onset velocity ratio is slower, and the coarse granule surface area is little and influence absorbs, bioavailability is lower, for it is bigger to reach the amount that therapeutic purposes need take, just can deal with problems.
Summary of the invention: the objective of the invention is to: a kind of Radix Schefflerae Arboricolae soft capsule and preparation method thereof is provided, this medicine is a kind of soft capsule preparation, the extract of its Radix Schefflerae Arboricolae is without granulation in manufacturing process, it is dispersed in the oily substrate, through rubber compacting sealing fully, overcome moisture absorption, increased medicine stability, improved bioavailability, strengthened the curative effect of medicine, reduce the quantity of taking, alleviate patient's psychological burden; The present invention constitutes like this: the Radix Schefflerae Arboricolae soft capsule is to calculate according to composition by weight, and it is formulated by 1 part of Radix Schefflerae Arboricolae extract and edible oil 0.3-3 part, Cera Flava 0.005-0.035 part; Specifically: calculate according to composition by weight, it is formulated by 1 part of Radix Schefflerae Arboricolae extract and 1 part in Oleum Glycines, 0.02 part in Cera Flava; This Radix Schefflerae Arboricolae preparation of soft capsule method, according to composition by weight: with Radix Schefflerae Arboricolae adopt water carry or the method for alcohol extraction extract 1 part of extract again with edible oil 0.3-3 part, Cera Flava 0.005-0.035 part mix homogeneously, fill, be pressed into soft capsule; Specifically: get the water that Radix Schefflerae Arboricolae adds 6-20 times of weight, decoct 1-4 time, collecting decoction, filter, it is 1.15-1.20 (60 ℃) that filtrate decompression is concentrated into relative density, adds ethanol and reaches 50-80% to containing the alcohol amount, staticly settles, filter, filtrate recycling ethanol and to be concentrated into relative density be 1.20-1.25 (60 ℃), drying gets extract dry powder, and dry powder is crossed 100 mesh sieves, add edible oil and Cera Flava according to given ratio again, mixing, is pressed into soft capsule at fill, and edible oil is except that Oleum Glycines, can be commercially available edible oil, as: vegetable oil, Oleum Arachidis hypogaeae semen, mixed oil or the like.
Compared with prior art: the present invention constitutes simply, manufacture method is uncomplicated, production technology is controlled easily, can guarantee the quality of medicine, in fact Radix Schefflerae Arboricolae circulates on market as relevant medicine, but because the problem of its existence, so the applicant has carried out new research in process of the test, mainly be research at dosage form, by studies show that: prepare this medicine with Radix Schefflerae Arboricolae as primary raw material, in oral drug, select for use other dosage form all can not reach the purpose of invention preferably; The pharmaceutical formulation or the powdered granule that have are big, and bioavailability is low, patient's assimilation effect is poor, and curative effect is undesirable; Use the extra fine powdered granule when dosage form that has prepares, but do not satisfy the requirement of production technology again; Such as making tablet, if the granule of raw material tiny especially, do not add adhesive and granulate, will make preparation relatively difficulty, influence the quality of medicine; So process repetition test the applicant has selected and has been made into soft capsule preparation; Because the extract of Radix Schefflerae Arboricolae is without granulation in manufacturing process, it is dispersed in the oily substrate, through rubber compacting sealing fully, overcome moisture absorption, increased the stability of medicine, the medicine in the soft capsule is an impalpable powder, directly is distributed in the body fluid after the disintegrate to absorb, onset is than very fast, and to be easy to absorb bioavailability more greatly higher because of surface area, strengthened the curative effect of medicine, and the dosage of this medicine is determined in for the treatment of associated conditions, dose is little; Under the contrast, soft capsule dose every day is equivalent to active substance 1.8g, and tablet dose every day is equivalent to active substance 2.7g-4.5g; This medicine is used for treatment of diseases such as trigeminal neuralgia, nervous headache, sciatica, rheumatic arthritis, and curative effect is more sure; Oral one time 3, three times on the one.
Embodiments of the invention 1: get the water that Radix Schefflerae Arboricolae adds 16 times of weight, decoct 2 times, collecting decoction, filter, it is 1.15-1.20 (60 ℃) that filtrate decompression is concentrated into relative density, add ethanol and reach 60% to containing the alcohol amount, staticly settle, filter, filtrate recycling ethanol and to be concentrated into relative density be 1.20-1.25 (60 ℃), drying gets extract dry powder, dry powder is crossed 100 mesh sieves, ratio according to 1 kilogram of Radix Schefflerae Arboricolae extract and 1 kilogram in Oleum Glycines, 0.02 kilogram in Cera Flava adds Oleum Glycines and Cera Flava again, and mixing, is pressed into soft capsule at fill.
Embodiments of the invention 2: get the water that Radix Schefflerae Arboricolae adds 20 times of weight, decoct 4 times, collecting decoction, filter, it is 1.15-1.20 (60 ℃) that filtrate decompression is concentrated into relative density, add ethanol and reach 80% to containing the alcohol amount, staticly settle, filter, filtrate recycling ethanol and to be concentrated into relative density be 1.20-1.25 (60 ℃), drying gets extract dry powder, dry powder is crossed 100 mesh sieves, add Oleum Glycines and Cera Flava according to 1 kilogram of ratio with 3 kilograms of vegetable oils, 0.035 kilogram in Cera Flava of Radix Schefflerae Arboricolae extract again, mixing, is pressed into soft capsule at fill.
Embodiments of the invention 3: get the water that Radix Schefflerae Arboricolae adds 6 times of weight, decoct 1 time, collecting decoction, filter, it is 1.15-1.20 (60 ℃) that filtrate decompression is concentrated into relative density, add ethanol and reach 50% to containing the alcohol amount, staticly settle, filter, filtrate recycling ethanol and to be concentrated into relative density be 1.20-1.25 (60 ℃), drying gets extract dry powder, dry powder is crossed 100 mesh sieves, add Oleum Glycines and Cera Flava according to 1 kilogram of ratio with 0.3 kilogram of mixed oil, 0.005 kilogram in Cera Flava of Radix Schefflerae Arboricolae extract again, mixing, is pressed into soft capsule at fill.
Embodiments of the invention 4: get Radix Schefflerae Arboricolae and carry out alcohol extraction according to routine techniques with ethanol, the extract dry powder that obtains sieves, again according to the ratio of 1 kilogram of Radix Schefflerae Arboricolae extract and 1.5 kilograms in Oleum Glycines, 0.005 kilogram in Cera Flava with Oleum Arachidis hypogaeae semen and Cera Flava, mixing, is pressed into soft capsule at fill.
The present invention provides a kind of new pharmaceutical dosage form for the utilization of Radix Schefflerae Arboricolae, we find in carrying out actual detected: use existing tablet, the dose of every day is equivalent to active substance 2.7-4.5 gram, and medicine dose every day provided by the invention is equivalent to active substance 1.8 grams; In the operation instruction of tablet, stipulated oral every day of three times, one time 3-5 sheet, and only needing to take 3, this medicine gets final product; That is to say: dose is less than the dose of existing medicine under equal curative effect state, save medicine resource like this, reduced production cost, solved that the patient takes tablet in a large number to needs and the psychoreaction that produces detest can reasonablely be treated associated conditions.

Claims (4)

1, a kind of Radix Schefflerae Arboricolae soft capsule is characterized in that: calculate according to composition by weight, it is formulated by 1 part of Radix Schefflerae Arboricolae extract and edible oil 0.3-3 part, Cera Flava 0.005-0.035 part.
2, according to the described Radix Schefflerae Arboricolae soft capsule of claim 1, it is characterized in that: calculate according to composition by weight, it is formulated by 1 part of Radix Schefflerae Arboricolae extract and 1 part in Oleum Glycines, 0.02 part in Cera Flava.
3, a kind of Radix Schefflerae Arboricolae preparation of soft capsule method, it is characterized in that: according to composition by weight: with Radix Schefflerae Arboricolae adopt water carry or the method for alcohol extraction extract 1 part of extract again with edible oil 0.3-3 part, Cera Flava 0.005-0.035 part mix homogeneously, fill, be pressed into soft capsule.
4, according to the described Radix Schefflerae Arboricolae preparation of soft capsule of claim 3 method, it is characterized in that: get the water that Radix Schefflerae Arboricolae adds 6-20 times of weight, decoct 1-4 time, collecting decoction, filter, it is 1.15-1.20 (60 ℃) that filtrate decompression is concentrated into relative density, add ethanol and reach 50-80%, staticly settle, filter to containing the alcohol amount, filtrate recycling ethanol and to be concentrated into relative density be 1.20-1.25 (60 ℃), drying gets extract dry powder, and dry powder is crossed 100 mesh sieves, adds edible oil and Cera Flava according to given ratio again, mixing, is pressed into soft capsule at fill.
CN 03117241 2003-01-24 2003-01-24 Schefflera (Hantaoye) soft capsule and preparing method thereof Expired - Lifetime CN1255131C (en)

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Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1293910C (en) * 2005-02-25 2007-01-10 张海峰 Compound gastrodin injection and its preparation and use
CN102600369A (en) * 2011-01-20 2012-07-25 北京联馨药业有限公司 Traditional Chinese medicine composition for treating migraine, as well as preparation method and usage thereof
CN102836190A (en) * 2012-09-25 2012-12-26 广西金海堂药业有限责任公司 Preparation method and quality control method for schefflera kwangsiensis general flavone extract
CN106727796A (en) * 2015-11-19 2017-05-31 哈尔滨圣吉药业股份有限公司 A kind of CAULIS SCHEFFLERAE KWANGSIENSIS dispersible tablet and preparation method thereof
CN110279735A (en) * 2019-08-09 2019-09-27 金鸿药业股份有限公司 A kind of CAULIS SCHEFFLERAE KWANGSIENSIS active component and preparation method thereof

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1293910C (en) * 2005-02-25 2007-01-10 张海峰 Compound gastrodin injection and its preparation and use
CN102600369A (en) * 2011-01-20 2012-07-25 北京联馨药业有限公司 Traditional Chinese medicine composition for treating migraine, as well as preparation method and usage thereof
CN102836190A (en) * 2012-09-25 2012-12-26 广西金海堂药业有限责任公司 Preparation method and quality control method for schefflera kwangsiensis general flavone extract
CN106727796A (en) * 2015-11-19 2017-05-31 哈尔滨圣吉药业股份有限公司 A kind of CAULIS SCHEFFLERAE KWANGSIENSIS dispersible tablet and preparation method thereof
CN110279735A (en) * 2019-08-09 2019-09-27 金鸿药业股份有限公司 A kind of CAULIS SCHEFFLERAE KWANGSIENSIS active component and preparation method thereof
CN110279735B (en) * 2019-08-09 2021-07-09 金鸿药业股份有限公司 Effective part of Chinese walnut leaf and preparation method thereof

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