CN1446597A - Device for admitting, asymmetric pulse ions (electrophoresis) with bi-directional equilibrium - Google Patents
Device for admitting, asymmetric pulse ions (electrophoresis) with bi-directional equilibrium Download PDFInfo
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- CN1446597A CN1446597A CN 02111151 CN02111151A CN1446597A CN 1446597 A CN1446597 A CN 1446597A CN 02111151 CN02111151 CN 02111151 CN 02111151 A CN02111151 A CN 02111151A CN 1446597 A CN1446597 A CN 1446597A
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Abstract
A bidirectional balanced asymmetrical pulse ion (electrophoresis) introducing apparatus for ion-introduction therapy is composed of a voltage-stabilized rectified power supply, two switch transistor with different polarities, a square-wave generator for controlling two switch transistors, two voltage-dividing resistors and two output electrode. When the ion-introduction therapy is conducting, the liquid medicine is poured in body cavity (ampula recti) and the electrodes are fixed on body surface for introducing the medicine ions into human body.
Description
(1) technical field:
The present invention relates to a kind of equipment that iontophoresis is used that is applied to, a kind of bidirectional balanced asymmetry pulse with low internal resistance on-off circuit output is made the therapeutic equipment that body cavity perfusion electrophoresis imports, a kind of bidirectional balanced asymmetry pulse ion (electrophoresis) introducing apparatus.
(2) background technology:
Ion introducing apparatus is a kind of instrument of treatment disease.Be direct current (containing polarization pulse) electric field action with instrument output in human body, make the active ingredient in the ionizing medicinal liquid in the electrode lower liner under the effect of electric field force, import tissue, reach the purpose of curing the disease.
Chinese patent application 97106277.3 has been introduced a kind of unidirectional square-wave frequency modulation intermediate frequency ion introducing apparatus, owing to adopt the way of output of the low straight coupling of internal resistance switch, select to be fit to the pulse switch ratio of human body impedance charge-discharge characteristic, make the peak point current of pulse can reach very big numerical value, and easily penetrate high tissue of capacitive reactance and cell membrane, form the superpower preferably polarized electric field of linear distribution in vivo, help the medicine ion targeting and import deep tissue.So therapeutic effect is better.But because in the unidirectional pulse therapeutic process, horny layer of epidermis still exists the process of polarizing voltage self discharge heat production in interpulse period, and exists under the electrode and be difficult to overcome the disperse of soda acid product causes chemical burn to skin side probability because of gathering of electrolysate.
Chinese patent application 98111091.6 has been introduced a kind of bidirectional HF square-wave electrotherapy instrument, and when the pulse of output was the waveform of asymmetric (imbalance), its electric current included DC component, can be used for iontophoresis.Because circuit adopts low internal resistance, the straight coupling way of output of two-way switch, act on human body with unbalanced high-frequency impulse, so avoided the keratodermatitis electric heating that polarizing voltage causes through the self discharge heat production in interpulse period to burn and the skin irritation sense when treating effectively.But during owing to uneven output, still have the soda acid product to take place under the electrode, so can not eliminate the probability that chemical burn takes place in the therapeutic process fully.
(3) summary of the invention:
Task of the present invention is to propose a kind ofly to be exclusively used in that perfusion imports medicinal liquid, carries out the therapeutic instrument that the targeting electrophoresis imports treatment, a kind of bidirectional balanced asymmetry pulse ion (electrophoresis) introducing apparatus through external electrode in the deep tissue (body cavity).It is narrow and high that this instrument can produce positive half cycle, bidirectional balanced (waiting electric weight) impulse wave that negative half period is wide and low.During use, electrode is affixed on body surface, and polarized electric field betides deep tissue, and the reaction that do not produce electrolysis under the external electrode does not produce the soda acid product, and skin electrochemistry can not take place burns.
This bidirectional balanced asymmetry pulse ion (electrophoresis) introducing apparatus, comprise rectifying voltage regulator, two opposite polarity switch triodes, a square-wave generator, two divider resistances, first output electrode and second output electrode, be connected between the both positive and negative polarity of power supply after the series connection of two divider resistances, the junction point between two divider resistances and second output electrode link, the base stage and the base stage of described two switch triodes link, emitter stage and emitter stage link, this emitter stage also links with first output electrode, the colelctor electrode of two switch triodes joins with the both positive and negative polarity of power supply respectively, and two outfans of described square-wave generator are received respectively on the base stage and emitter stage of two switch triodes.Described divider resistance resistance is unequal, and the high-end divider resistance resistance of voltage is big, and the divider resistance resistance of voltage low side is little, and described square-wave generator is the asymmetric square-wave generator that the positive half cycle time is short, the negative half period time is long.
This bidirectional balanced asymmetry pulse ion (electrophoresis) introducing apparatus, the divider resistance resistance high-end owing to voltage is big, the divider resistance resistance of voltage low side is little, and the waveform of square-wave generator output is the asymmetric square wave that the positive half cycle time is short, the negative half period time is long, the conducting of two switch triodes of Waveform Control of square-wave generator output and ending makes the output waveform of this bidirectional balanced asymmetry pulse ion (electrophoresis) introducing apparatus become the bidirectional pulse ripple that positive half cycle is narrow and high, negative half period is wide and low.Carry out iontophoresis with this bidirectional balanced asymmetry pulse ion (electrophoresis) introducing apparatus, perfusion imports medicinal liquid in body cavity (ampulla of rectum), and electrode is fixed on the body surface, makes the electric field of formation pass the body cavity position at place.During positive half cycle, can obtain very big pulse peak current in vivo, can effectively medicine ion be imported in the body, reach therapeutic effect.The pulse current peak is little during negative half period, the shallow table of the function of current, can not be by the capacitance structure of deep tissue, and mainly on electrode, produce reverse unpolarizing, so polarized electric field betides deep tissue, and the reaction that do not produce electrolysis under the external electrode, do not produce the soda acid product, skin can not cause that electrochemistry burns.
(4) description of drawings:
Accompanying drawing 1 is the basic block diagram of this bidirectional balanced asymmetry pulse ion (electrophoresis) introducing apparatus;
Accompanying drawing 2 is the output waveform figure of square-wave generator;
Accompanying drawing 4 is the another kind of structure chart of bidirectional balanced asymmetry pulse ion (electrophoresis) introducing apparatus;
Accompanying drawing 5 is the structure chart of square-wave generator;
Accompanying drawing 6 is the structure chart of rectifying voltage regulator.
(5) specific embodiment:
As shown in Figure 1, this bidirectional balanced asymmetry pulse ion (electrophoresis) introducing apparatus comprises rectifying voltage regulator 1, two opposite polarity switch triode T1, T2, square-wave generator 8, two divider resistances 2,4, first output electrode 6 and second output electrodes 7.Be connected between the both positive and negative polarity of power supply after the series connection of two divider resistances, the junction point 10 between two divider resistances and second output electrode 7 link.Base stage and the base stage of described two switch triode T1, T2 link, and emitter stage and emitter stage link, and this emitter stage also links with first output electrode 6, and the colelctor electrode of two switch triodes joins with the both positive and negative polarity of power supply respectively.Two outfans of described square-wave generator 8 are received respectively on the base stage and emitter stage of two switch triodes.Described divider resistance resistance is unequal, and high-end divider resistance 2 resistances of voltage are big, and divider resistance 4 resistances of voltage low side are little.Described square-wave generator is a short long asymmetric square-wave generator of negative half period time of positive half cycle time.
As shown in Figure 2, the waveform of square-wave generator 8 outputs is asymmetric square waves that the positive half cycle time is short, the negative half period time is long.During positive half cycle, T1 conducting, T2 end among Fig. 1, and the current potential of first output electrode 6 is higher than second output electrode 7, the output positive pulse.During negative half period, T2 conducting, T1 end, the output negative pulse.So the impulse waveform that bidirectional balanced asymmetry pulse ion (electrophoresis) introducing apparatus is exported is the positive bidirectional pulse ripple that half cycle is narrow and high, negative half period is wide and low just as shown in Figure 3.For example, divider resistance 2 and 4 ratio are 10: 1, the positive-negative half-cycle width ratio of the impulse waveform of square-wave generator 8 outputs is 1: 10 o'clock, and the DC component of bidirectional balanced asymmetry pulse ion (electrophoresis) introducing apparatus output waveform is near zero, and electrolysis is almost nil.
As shown in Figure 4, this bidirectional balanced asymmetry pulse ion (electrophoresis) introducing apparatus can also comprise two opposite polarity emitter-base bandgap grading output triode T3, T4, after linking, the base stage of above-mentioned two emitter-base bandgap grading output triodes receives on the junction point 10 between the divider resistance 2,4, their two colelctor electrodes connect between the both positive and negative polarity of receiving power supply respectively, link with second output electrode 7 after their emitter stage links.After having increased by two emitter-base bandgap grading output triode T3, T4, the internal resistance of outfan is greatly reduced, help the output pulse current that provides bigger.
As shown in Figure 4, in this bidirectional balanced asymmetry pulse ion (electrophoresis) introducing apparatus, after can also being in series with a current-limiting resistance 9, the colelctor electrode of the switch triode T2 that described and power cathode joins links with power cathode again.This current-limiting resistance 9 can make the pulse front edge steepness of negative half period diminish, and can reduce electric current to the depth of interaction of tissue and the linearity that distributes.This current-limiting resistance also can replace with a constant-current circuit.
Square-wave generator in this bidirectional balanced asymmetry pulse ion (electrophoresis) introducing apparatus can adopt square-wave generator commonly used.For example, the square-wave generator of forming with 555 integrated packages and resistance 11,12 that is shown in Figure 5.Suitably choose the resistance of resistance 11,12, can obtain short long asymmetric square wave of negative half period time of required positive half cycle time.
Rectifying voltage regulator in this bidirectional balanced asymmetry pulse ion (electrophoresis) introducing apparatus can adopt conventional power supply, also can adopt structure shown in Figure 6, form by step-down rectifying circuit 13, medium-frequency oscillator booster circuit 14 and intermediate frequency regulator rectifier circuit 15.Such power supply architecture can play the effect of insulating power supply, is convenient to adjust the relative current potential between the each several part circuit.
This bidirectional balanced asymmetry pulse ion (electrophoresis) introducing apparatus at amplitude that suitably changes little negative pulse and width, when producing DC component, also can be used in the electrode lower liner and add the instrument of medicine as subcutaneous iontophoresis.
Claims (3)
1, a kind of bidirectional balanced asymmetry pulse ion (electrophoresis) introducing apparatus, comprise rectifying voltage regulator (1), two opposite polarity switch triodes (T1), (T2), a square-wave generator (8), two divider resistances (2), (4), first output electrode (6) and second output electrode (7), be connected between the both positive and negative polarity of power supply after the series connection of two divider resistances, junction point between two divider resistances (10) links with second output electrode (7), described two switch triodes (T1), (T2) base stage and base stage link, emitter stage and emitter stage link, this emitter stage also links with first output electrode (6), the colelctor electrode of two switch triodes joins with the both positive and negative polarity of power supply respectively, two outfans of described square-wave generator (8) are received respectively on the base stage and emitter stage of two switch triodes, it is characterized in that, described divider resistance resistance is unequal, high-end divider resistance (2) resistance of voltage is big, the divider resistance of voltage low side (4) resistance is little, and described square-wave generator is a short long asymmetric square-wave generator of negative half period time of positive half cycle time.
2, bidirectional balanced asymmetry pulse ion as claimed in claim 1 (electrophoresis) introducing apparatus, it is characterized in that it also comprises two opposite polarity emitter-base bandgap grading output triodes (T3), (T4), after linking, the base stage of above-mentioned two emitter-base bandgap grading output triodes receives on the junction point (10) between divider resistance (2), (4), the both positive and negative polarity that their two colelctor electrodes connect respectively with power supply joins, and their the emitter stage back that links links with second output electrode (7).
3, bidirectional balanced asymmetry pulse ion as claimed in claim 1 or 2 (electrophoresis) introducing apparatus is characterized in that joining with power cathode after the colelctor electrode of the switch triode (T2) that described and power cathode join and a current-limiting resistance (9) are in series again.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 02111151 CN1262320C (en) | 2002-03-21 | 2002-03-21 | Device for admitting, asymmetric pulse ions (electrophoresis) with bi-directional equilibrium |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 02111151 CN1262320C (en) | 2002-03-21 | 2002-03-21 | Device for admitting, asymmetric pulse ions (electrophoresis) with bi-directional equilibrium |
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| Publication Number | Publication Date |
|---|---|
| CN1446597A true CN1446597A (en) | 2003-10-08 |
| CN1262320C CN1262320C (en) | 2006-07-05 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN 02111151 Expired - Fee Related CN1262320C (en) | 2002-03-21 | 2002-03-21 | Device for admitting, asymmetric pulse ions (electrophoresis) with bi-directional equilibrium |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101036825B (en) * | 2007-04-20 | 2010-05-19 | 济南奥尔尼医疗器械有限公司 | High-voltage potential therapeutic apparatus for outputting asymmetric composite wave |
| CN103248263A (en) * | 2012-02-09 | 2013-08-14 | 中兴通讯股份有限公司 | PWM DC pulse circuit, coating circuit and film coating method |
| CN108904973A (en) * | 2018-04-26 | 2018-11-30 | 李珍 | It is a kind of for electrotherapy when protect bio-safety method and equipment |
-
2002
- 2002-03-21 CN CN 02111151 patent/CN1262320C/en not_active Expired - Fee Related
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101036825B (en) * | 2007-04-20 | 2010-05-19 | 济南奥尔尼医疗器械有限公司 | High-voltage potential therapeutic apparatus for outputting asymmetric composite wave |
| CN103248263A (en) * | 2012-02-09 | 2013-08-14 | 中兴通讯股份有限公司 | PWM DC pulse circuit, coating circuit and film coating method |
| CN103248263B (en) * | 2012-02-09 | 2017-02-15 | 中兴通讯股份有限公司 | PWM DC pulse circuit, coating circuit and film coating method |
| CN108904973A (en) * | 2018-04-26 | 2018-11-30 | 李珍 | It is a kind of for electrotherapy when protect bio-safety method and equipment |
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| Publication number | Publication date |
|---|---|
| CN1262320C (en) | 2006-07-05 |
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Owner name: JIAXING CITY DAYANG MEDICAL TECHNOLOGY CO., LTD. Free format text: FORMER OWNER: FU CHUNNONG Effective date: 20070907 |
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Effective date of registration: 20070907 Address after: Jiaxing City, Zhejiang province 314001 South Road No. four Building No. 1 Jiaxing Bridge Branch Center Patentee after: Dayang Medical Science & Tech. Co., Ltd., Jiaxing City Address before: 314000 Jiaxing First Hospital of Zhejiang Province Patentee before: Fu Chunnong |
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Granted publication date: 20060705 Termination date: 20100321 |