CN1438892A

CN1438892A - Low carbony drate compositions, kits thereof, and methods of use

Info

Publication number: CN1438892A
Application number: CN01810982A
Authority: CN
Inventors: M·T·海斯; K·N·科恩; K·E·司潘斯
Original assignee: Procter and Gamble Ltd
Current assignee: Procter and Gamble Ltd; Procter and Gamble Co
Priority date: 2000-06-02
Filing date: 2001-06-01
Publication date: 2003-08-27
Also published as: CA2408610A1; WO2001093831A2; WO2001093831A3; EP1289532A2; MXPA02011939A; JP2003535120A; BR0111292A; AU2001269730A1

Abstract

The present invention relates to compositions, kits, and methods utilized for the treatment of joint dysfunction, bone dysfunction, and / or inflammation. The composition utilized herein are useful for those mammals experiencing painful or debilitating joint, bone, or inflammatory conditions, and are particularly suited for mammals which are diabetic or at risk for diabetes, as well as those desiring or requiring conveniently dosed chondroprotective compositions having low carbohydrate content, low caloric value and / or having a low glycemic index. In particular, the present compositions comprise: a) a chondroprotective agent selected from gelatin, cartilage, aminosugars, glycosaminoglycans, methylsulfonylmethane, precursors of methylsulfonylmethane, S-adenosylmethionine, and mixtures thereof; b) a sweetening agent other than glucose, dextrose, sucrose, and fructose; and c) at least about 10 % water, by weight of the composition. In an alternative embodiment of the present invention, the present compositions comprise: a) a chondroprotective agent selected from gelatin, cartilage, aminosugars, glycosaminoglycans, methylsulfonylmethane, precursors of methylsulfonylmethane, S-adenosylmethionine, salts thereof, and mixtures thereof; and b) a sweetening agent other than glucose, dextrose, sucrose, and fructose; wherein the composition is substantially free of aspartame.

Description

Low-carb compositions, its cover box and using method thereof

Invention field

The present invention relates to can be used for to promote to comprise compositions as one or more health advantages of articulation health, bone health and/or antiinflammatory.The invention still further relates to the cover box that comprises said composition and use said composition and the method for cover box.

Background of invention

Osteoarthritis is the degenerative disease of general joint, cartilage and other joint tissue.Osteoarthritis has influenced all races all over the world.Except the people, osteoarthritis also influences nearly all mammal, for example horse and cattle and domestic cat and Canis familiaris L..Proposed the therapy of many osteoarthritis, all methods all can produce effect in various degree.

A kind of osteoarthritis treatment method that proposes is oral Chondroprotective agents such as glycosamine and/or chrondroitin recently.Referring to as authorized Henderson on November 15th, 1994, transfer No. 5,364,845, the United States Patent (USP) of NutramaxLaboratories.In fact, extensive stock is arranged on the market, comprise the nutritional supplement that contains these medicaments and can prepare powder in the beverage composition for treating dental erosion into before use immediately.

In general, taking these medicaments is in order to improve proteoglycan by the concentration that improves glucosaminoglycan.The proteoglycan that improves can be collagen and other joint tissue provides skeleton, and pliability, elasticity and crushing resistance are provided.Therefore, can take these medicaments, to strengthen articulation structure or to suppress degenerative process at least according to the whole bag of tricks.

Chondroprotective agents can be with composition forms (for example fruit juice) transmission with high sugared content, to strengthen compliance by palatability or the convenience of improving this reagent.But compositionss of these high sugar are that heat is high and blood sugar content is raise.These are undesirable for ordinary consumer, and are unfavorable especially for the too high and fat crowd of those body weight, perhaps even for the crowd of the importance of the picked-up of only knowing caloric restriction and sugar also do not expect.

In addition, because they are to the potential impact of the blood sugar content of system, the diabetes patient gets rid of the high sugar composite of this class of picked-up possibly.But also find that in fact some Chondroprotective agents can influence the stability of blood sugar content unfriendly.But making us difficult to manage is diabetics has most critical usually to these Chondroprotective agents demand.The requirement section ground of this key is because the body weight that diabetics occurs usually is too high, and this can cause the pressure on joint, cartilage and other joint assembly to increase, and finally causes osteoarthritis.

As described herein, the inventor has overcome the restricted of cartilage protection compositions in the past.The inventor provides the compositions that comprises one or more Chondroprotective agents at this, and it provides with convenient and good to eat form, and this has not only increased compliance but also has been very suitable for needing to reduce the individuality of heat and Sugar intake.Therefore, this compositions is applicable to the mammal of standing osteoarthritis of wide region in the world wide unexpectedly.These and other benefit of the present invention is in following detailed description.

Brief summary of the invention

The present invention relates to be used for the treatment of compositions, cover box and the method for joint malfunction, bone malfunction and/or inflammation.This compositions is to be applicable to experience mammal pain and weak joint, bone or inflammatory conditions; with be specially adapted to diabetes or the mammal of diabetes risk arranged, and wish or require to take easily have low carbohydrate content, lower calorific value and/or the low-glycemic mammal of cartilage protection compositions of (glycemic index).

Especially, this compositions comprises:

A) be selected from gelatin, cartilage, amino sugar, glucosaminoglycan, methylsulfonyl methane, methylsulfonyl methane precursor, S-adenosylmethionine, and composition thereof Chondroprotective agents;

B) except the sweeting agent of glucose, dextrose, sucrose and fructose; With

C) composition weight is at least about 10% water.

In another embodiment of the present invention, this compositions comprises:

A) be selected from gelatin, cartilage, amino sugar, glucosaminoglycan, methylsulfonyl methane, methylsulfonyl methane precursor, S-adenosylmethionine, its salt, and composition thereof Chondroprotective agents; With

B) except the sweeting agent of glucose, dextrose, sucrose and fructose;

The essentially no aspartame of compositions wherein.

In another embodiment of the present invention, this compositions comprises: a) be selected from gelatin, cartilage, amino sugar, glucosaminoglycan, methylsulfonyl methane, methylsulfonyl methane precursor, S-adenosylmethionine, its salt, and composition thereof Chondroprotective agents; B) composition weight is at least about 10% water; And c) per 230 milliliters of these compositionss are lower than the total carbohydrates of about 18 grams.

In another embodiment of the present invention, this compositions comprises: a) be selected from gelatin, cartilage, amino sugar, glucosaminoglycan, methylsulfonyl methane, methylsulfonyl methane precursor, S-adenosylmethionine, its salt, and composition thereof Chondroprotective agents; And b) per 230 milliliters of these compositionss are lower than the total carbohydrates of about 18 grams; The essentially no aspartame of compositions wherein.

The invention still further relates to the food, beverage, medicine, OTC (over-the-counter) and the meals that comprise this compositions and augment product.This product is applicable to mammal.The invention still further relates to the cover box that comprises this compositions and relevant information, this information notification uses said composition to promote one or more health advantages defined herein, comprises articulation health, bone health and antiinflammation.The invention still further relates to the method for treatment function of joint, bone function or inflammation, comprise compositions to administration this paper definition.

Detailed Description Of The Invention

The present invention relates to be used for that for example food, beverage, medicine, OTC (over-the-counter) and meals are augmented the product combination thing.This Food ﹠ Drink product comprises conventional Food ﹠ Drink, and the Food ﹠ Drink that are divided into " dietetic food " by the regulations criterion.This product is applicable to mammal, is specially adapted to people and domestic animal such as Canis familiaris L., cat, Ma Heniu.The invention still further relates to the cover box that comprises said composition and use these method for compositions.

Compositions of the present invention is applicable to provides a kind of and multiple articulation health, bone health and/or antiinflammatory benefit.The articulation health benefit is including, but not limited to symptom that prevents, suppresses, stops and/or reverse arthritis, particularly osteoarthritis and/or phenomenon.Thereby the articulation health of improvement can provide, for example suppress joint assembly decline, alleviate the pliability of joint pain and/or increase.The bone health benefit is including, but not limited to preventing, suppress, stop and/or reverse bone loss and/or structure osseous tissue, and/or prevents, suppresses, stops and/or reverse osteoporosis.Thereby, the osseous tissue that the bone health of improvement can provide the bone as health, stronger bone and/or increase.The antiinflammatory benefit comprises as preventing, suppress, stop and/or reverse the inflammation of inflammation, particularly joint.Thereby antiinflammatory usually can cause pain relief.

All be mentioned to publication and patent in the disclosure document in the whole text.All lists of references that this paper mentions all are incorporated herein by reference.

Unless other explanation is arranged, all percents and ratio all calculate by weight.Except as otherwise noted, all percents and ratio all are basic calculation with the total composition.

What all components or composition levels referred to all is the active quantities of component or compositions, and impurity disregards interior, and for example, remaining solvent or by-product may have these impurity in the source that is commercially available.

This paper is mentioned to the trade name of some components, and these components comprise the various compositions that the present invention adopts.Inventor of the present invention is not restricted to material the intention in some trade name scope.In compositions of the present invention, cover box and method, can substitute and the material of equal value of related those materials of commodity in use title (the material that for example, obtains) with different titles or catalogue (index) number from the difference source.

Here the total content of any given component of Cai Yonging comprises that any other adds this component that component inherence is contained in the component of any interpolation and the compositions.

In description of the present invention, various embodiments and/or concrete feature are disclosed.To those skilled in the art, all combinations of these embodiments and technical characterictic all are possible undoubtedly, and may become the preferred embodiments of the invention.

Compositions of the present invention, method and cover box can comprise any key element as herein described, perhaps can be basically by or form by these key elements.

Compositions of the present invention

This compositions is to be applicable to experience mammal pain and weak joint, bone or inflammation; with be specially adapted to diabetes or the mammal of diabetes risk arranged, and the mammal of wishing or require to take easily cartilage protection compositions with low carbohydrate content, lower calorific value and/or low-glycemic.

The present composition is applicable to as food, beverage, medicine, nonprescription drugs and meal supplement product.This product is applicable to mammiferous use, is specially adapted to people and domestic animal such as Canis familiaris L., cat, Ma Heniu.Preferably, compositions of the present invention is used for people and domestic animal.More preferably, compositions of the present invention is used for people, domestic Canis familiaris L. and family and keeps a cat.Most preferably, compositions of the present invention is used for the people.

According to one embodiment of the present invention, this compositions comprises: a) be selected from gelatin, cartilage, amino sugar, glucosaminoglycan, methylsulfonyl methane, methylsulfonyl methane precursor, S-adenosylmethionine, its salt, and composition thereof Chondroprotective agents; B) except the sweeting agent of glucose, dextrose, sucrose and fructose; And c) composition weight is at least about 10% water.

In another embodiment of the present invention, this compositions comprises: a) be selected from gelatin, cartilage, amino sugar, glucosaminoglycan, methylsulfonyl methane, methylsulfonyl methane precursor, S-adenosylmethionine, its salt, and composition thereof Chondroprotective agents; And b) except the sweeting agent of glucose, dextrose, sucrose and fructose; The essentially no aspartame of compositions wherein.

Preferably, the carbohydrate content of this compositions is low.Preferably, this compositions has the carbohydrate content that per 230 milliliters of said compositions are lower than about 19 gram total carbohydrates.More preferably, this compositions has the carbohydrate content that per 230 milliliters of said compositions are lower than about 18.5 gram total carbohydrates.Preferred again, this compositions has the carbohydrate content that per 230 milliliters of said compositions are lower than about 18 gram total carbohydrates.Most preferably, this compositions has the carbohydrate content that per 230 milliliters of said compositions are lower than about 17.5 gram total carbohydrates.The term here " carbohydrate content " is definite by measuring " difference " by this area standard method, promptly measures total amino acids content, moisture, lipid content and the ash content of coal of given compositions to be determined.All the other composition measurements of these compositionss are the total carbohydrates content of said composition, and term " carbohydrate content " shows with the total carbohydrates scale of per 230 milliliters of said compositions.

Therefore, in one embodiment of this invention, this compositions comprises: a) be selected from gelatin, cartilage, amino sugar, glucosaminoglycan, methylsulfonyl methane, methylsulfonyl methane precursor, S-adenosylmethionine, its salt, and composition thereof Chondroprotective agents; B) composition weight is at least about 10% water; And c) per 230 milliliters of these compositionss are lower than the total carbohydrates of about 19 grams.

In another embodiment of the present invention, this compositions comprises: a) be selected from gelatin, cartilage, amino sugar, glucosaminoglycan, methylsulfonyl methane, methylsulfonyl methane precursor, S-adenosylmethionine, its salt, and composition thereof Chondroprotective agents; And b) per 230 milliliters of these compositionss are lower than the total carbohydrates of about 19 grams; The essentially no aspartame of compositions wherein.

The various components of this compositions are below described.Said composition is specially adapted to treat mammiferous function of joint, bone function and/or inflammation.Most preferably, said composition is applicable to the mammiferous function of joint of treatment and inflammation, especially function of joint. Chondroprotective agents

The Chondroprotective agents that is used for this compositions be selected from the precursor of gelatin, cartilage, amino sugar, glucosaminoglycan, methylsulfonyl methane, methylsulfonyl methane, S-adenosylmethionine, and composition thereof.This component is to be particularly useful for providing bone health, articulation health and antiinflammatory, most preferably is articulation health, key component.

Without being limited by theory, because this composition can help in vivo stimulatory protein(SP) polysaccharide and collagen, Chondroprotective agents is very important for strengthening the joint function.Proteoglycan provides connective tissue such as the essential collagen of articulation health.In fact, proteoglycan is made up of long chains of modified sugars glucosaminoglycan (being commonly referred to " GAGs ").Amino sugar and methylsulfonyl methane can be used for constructing glucosaminoglycan and proteoglycan.

Preferably, Chondroprotective agents is selected from gelatin, cartilage, amino sugar, glucosaminoglycan, S-adenosylmethionine, its salt and composition thereof.More preferably, Chondroprotective agents be selected from amino sugar, glucosaminoglycan, S-adenosylmethionine, and composition thereof.Even more preferably, Chondroprotective agents be selected from amino sugar, glucosaminoglycan, and composition thereof.Most preferably, Chondroprotective agents is the salt of amino sugar, and amino sugar wherein is a glycosamine especially.

Below describe various Chondroprotective agents and preferred embodiment thereof in detail.Usually; the final form that depends on said composition, this compositions comprise about 75%, about 20%, the Chondroprotective agents of 0.1%-about 10% and first-selection about 0.1%-about 2% more preferably from about of about 50%, the also preferred about 0.01%-of 0.001%-more preferably from about of about 0.0001%-of composition weight.For example, ready-to-drink beverage compositions more generally comprises about 10%, the Chondroprotective agents of about 2%, the first-selected about 0.01%-1% of 0.001%-more preferably from about of about 0.0001%-of composition weight.Dry type beverage composition for treating dental erosion (be suitable for dilution so that concentrate or ready-to-drink beverage compositions to be provided) more generally comprises about 75%, about 50%, preferred about 25%, the Chondroprotective agents of 15%-about 20% most preferably from about of about 5%-also of 2%-more preferably from about of about 1%-of composition weight.

In addition, the Sq of Chondroprotective agents can be expressed as quality dosage, and the preferred Chondroprotective agents of following each that list is provided separately.For the selection of dosage, all dosage all is based on general human agent (main bodys as 55 to 65kg).When wherein this compositions being used for other mammal, the essential dosage that changes.Those of ordinary skill can be well changes dosage according to the needs of main body.Therefore these dosage ranges should be understood just as an example, the dose of every day can be adjusted on various factors calmly.The specific taking dose of Chondroprotective agents and the persistent period of treatment are complementary.The method of dosage and treatment also depends on as used specific Chondroprotective agents, treatment guidance, the effectiveness of chemical compound, the individual characteristics (as body weight, age, sex and the health of main body) of main body and the factors such as compliance of Therapeutic Method.

Gelatin

Known to general, gelatin is the protein that comes from the collagen partial hydrolysis, and it is main structure in mammal and be connected the albumen tissue.Gelatin generally contain have an appointment 84% to about 90% protein, about 1% to about 2% mineral salt and about 8% to about 15% water (these are nonrestrictive approximation).Gelatin generally contains a certain amount of 18 kinds of different aminoacid, and these aminoacid are combined together to form the polypeptide chain that every chain has 1,000 amino acid residue approximately.

Usually, the collagen that is used for manufacturing of gelatin comes from animal bone and skin, as comes from bone and the skin of cattle and pig.Manufacturing of gelatin generally comprises and makes Collagen material stand the alkali pretreatment, uses hot water extraction (if the isoelectric point, IP of gelatin is about 5) subsequently.Also usable acid pretreatment (if the isoelectric point, IP of gelatin is about 7 to 9).

According to the present invention, wherein gelatin is included in the present composition, and the gelatin in the compositions of single dose is preferably about 1mg to about 2000mg, more preferably arrives about 700mg for about 100mg, even, be most preferably about 200mg to about 400mg more preferably for about 150mg arrives about 600mg.Usually, the compositions that contains gelatin can once arrive about five times dosed administration by making an appointment with every day.But, in the embodiment of the preferred Food ﹠ Drink compositions of the present invention, can correspondingly increase typical dosage and make administration only need once a day.Therefore, the compliance in these Food ﹠ Drink and the benefit of consumer have strengthened.

Cartilage

Can choose cartilage and comprise that the cartilage of hydrolysis is as the Chondroprotective agents in this compositions.As this area general known to, cartilage is the tough and tensile Elastic tissue in the joint (and other position) that is present in various body of mammals.Cartilage is by at least a composition the in calcium, protein, carbohydrate mucopolysaccharide (as chrondroitin) and the collagen.

Be applicable to herein particularly preferred for cattle cartilage and shark cartilage.The cattle cartilage mainly derives from the trachea (being also referred to as self-conceit pipe cartilage or BTC) of cattle.It is structurally similar with shark cartilage.Because the skeleton of shark mainly is made up of cartilage rather than bone, shark cartilage is widely used cartilage source.

According to the present invention, wherein cartilage is included in this compositions, and the cartilage in the compositions of single dose is preferably about 1mg to about 2000mg, more preferably arrives about 700mg for about 100mg, even, be most preferably about 200mg to about 400mg more preferably for about 150mg arrives about 600mg.Usually, the compositions that contains cartilage can once arrive about five times dosed administration by making an appointment with every day.But, in the embodiment of the preferred Food ﹠ Drink compositions of the present invention, can correspondingly increase typical dosage and make administration only need once a day.

Amino sugar

Can choose one or more amino sugars as chondroprotective agent herein.Amino sugar is the monosaccharide composition (being hexose) by the amine functional group modification.Amine functional group can be unhindered amina structure division or shielded amine structure part (as the N-acetyl amine).Preferably, amino sugar is for the precursor that constitutes the very important glucosaminoglycan of joint composition (as collagen).In addition, some amino sugar can be used to suppress involve the activity (as mannosamine, having found to suppress aggrecanase) of the enzyme of the cartilage that destroys the osteoarthritis patient.Amino sugar is well known in the art, and many amino sugars are naturally occurring.

Particularly preferred amino sugar comprises salt, the mannosamine of salt, galactosamine, the galactosamine of glycosamine, glycosamine, the salt of mannosamine, and above-mentioned N-acetyl derivative, comprises N-acetyl glucosamine and N-acetyl group galactosamine.More preferably, amino sugar comprises the salt of glycosamine and glycosamine, is most preferably the salt of glycosamine.The salt of particularly preferred glycosamine comprises glucosamine sulfate and glucosamine hydrochloride.The salt of glycosamine particularly preferably helps the bioavailability of amino sugar.

As an example, glycosamine can be provided at the required construction unit of glucosaminoglycan that in vivo manufacturing can be found in cartilage.Thereby glycosamine and other amino sugar not only work to alleviate the arthralgia symptom, but also can suppress, stop and/or reverse degenerative process.

Based on the molecular weight of glucosamine hydrochloride, the general single dose of amino sugar is preferably about 1mg to about 5000mg, more preferably for about 100mg arrives about 3600mg, even more preferably for about 150mg arrives about 2200mg, is most preferably about 250mg to about 1900mg.For example, the particularly preferred dosage of glucosamine hydrochloride is about 1800mg, is equivalent to the glycosamine of about 1480mg.Based on the molecular weight of glucosamine hydrochloride, can calculate the dosage of all other amino sugars similarly.Usually, the compositions that contains amino sugar can once arrive about five times approximately by every day, and preferred every day about one is to about three times dosed administration.But, in the embodiment of the preferred Food ﹠ Drink compositions of the present invention, can correspondingly increase typical dosage and make administration only need once a day.

Glucosaminoglycan

Can be with one or more glucosaminoglycans as chondroprotective agent herein.Glucosaminoglycan is commonly referred to GAGs, is the precursor of articulation structure such as collagen.Glucosaminoglycan is also very important to symphysis.

Concerning those of ordinary skill, suitable glycosaminoglycans is well-known.Preferred glucosaminoglycan comprises the salt of chrondroitin, hyaluronic acid, keratin, heparin and dermatin and above-mentioned substance.For example, chondroitin sulfate is particularly preferred chondroitin salt.For amino sugar, the salt of glucosaminoglycan is the particularly preferred salt that is applicable to herein.

As an example, chrondroitin can provide structure and allow various molecules by cartilage (this is very important, because there is not the blood supply cartilage).Chrondroitin is the main component of cartilage, contains the repetition chain of mucopolysaccharide.

Based on the molecular weight of chrondroitin, the general single dose of glucosaminoglycan is preferably about 1mg to about 10g, more preferably for about 100mg arrives about 5g, even more preferably for about 150mg arrives about 1000mg, is most preferably about 250mg to about 800mg.Based on the molecular weight of chrondroitin, can calculate the dosage of all other glucosaminoglycans similarly.Usually, the compositions that contains glucosaminoglycan can once arrive about five times dosed administration by making an appointment with every day.But, in the embodiment of the preferred Food ﹠ Drink compositions of the present invention, can correspondingly increase typical dosage and make administration only need once a day.

The precursor of methylsulfonyl methane and methylsulfonyl methane

Chondroprotective agent herein also can be methylsulfonyl methane or its precursor.Term used herein " its precursor " is meant the chemical compound that is converted into methylsulfonyl methane in mammlian system, in vivo.Methylsulfonyl methane and precursor thereof are for can be in vivo and occurring in nature, common constituent as finding in unprocessed food.Without being limited by theory, it has been generally acknowledged that the sulfur structure division that is present in methylsulfonyl methane and the precursor thereof can provide the disulfide bridge bond (also being commonly referred to " connecting rod " or " crosslinked ") with it is essential that the connective tissue in the joint is fixed together.

Though unprocessed food contains methylsulfonyl methane and precursor thereof, conventional food processing and preparation can make these chemical compounds run off from food.Therefore, can lack these chemical compounds in the food of picked-up usually.In these areas, methylsulfonyl methane and vitamin and minerals seemingly usually can partly or entirely run off in normal food processing and preparation.Therefore important embodiment of the present invention is to comprise methylsulfonyl methane or its precursor as Chondroprotective agents in the present composition.

The non-limitative example of the precursor of methylsulfonyl methane comprises methionine and dimethyl sulfide.Referring to as in JIUYUE, 1989 No. 4,863,748, the United States Patent (USP) of authorizing people such as Herschler on the 5th.The precursor of methylsulfonyl methane and various health advantages, comprise that joint benefit (as alleviating osteoarthritis and rheumatoid arthritis) and antiinflammatory are relevant.

According to the present invention, wherein methylsulfonyl methane is included in this compositions, methylsulfonyl methane in the compositions of single dose is preferably about 0.01mg to about 2000mg, more preferably arrive about 500mg for about 0.01mg, even, be most preferably about 1mg to about 100mg more preferably for about 1mg arrives about 200mg.Based on the molecular weight of precursor, can calculate the dosage of the precursor of methylsulfonyl methane similarly with respect to methylsulfonyl methane.Usually, the compositions that contains methylsulfonyl methane can once arrive about five times dosed administration by making an appointment with every day.But, in the embodiment of the preferred Food ﹠ Drink compositions of the present invention, can correspondingly increase typical dosage and make administration only need once a day.

S-adenosylmethionine

The S-adenosylmethionine that is commonly referred to SAM-e is for if not at whole living cells, the chemical compound that also can find in most of living cells.Without being limited by theory, SAM-e makes by essential amino acid methionine and the reaction that is called the kinetomeres of adenosine triphosphate (being commonly referred to ATP).SAM-e can make cartilaginous element and repair, recovers and the maintenance function of joint.SAM-e is in vivo made by amino acids methionine, can find in full diet is originated as meat, Semen sojae atricolor, egg, seed and Seem Lablab Album.

According to the present invention, wherein SAM-e is included in this compositions, and the SAM-e in the compositions of single dose is preferably about 1mg to about 2000mg, more preferably arrives about 700mg for about 100mg, even, be most preferably about 200mg to about 400mg more preferably for about 150mg arrives about 600mg.Usually, the compositions that contains SAM-e can once arrive about five times dosed administration by making an appointment with every day.But, in the embodiment of the preferred Food ﹠ Drink compositions of the present invention, can correspondingly increase typical dosage and make administration only need once a day. Sweeting agent

Here Ding Yi sweeting agent is the sweeting agent except glucose, dextrose, sucrose and fructose.But, the inventor does not wish to get rid of one or more sweeting agents that adopt in glucose, dextrose, sucrose and the fructose, so long as adopt glucose, dextrose, sucrose and/or fructose in the sweeting agent (hereinafter referred to as " caloric sweeteners ") that adopts this paper definition.

Sweeting agent is well known in the art.As described herein, in compositions, provide less or the sweeting agent of empty calory and low-glycemic is that this compositions is especially preferred.The non-limiting example of this class sweeting agent comprises sorbitol, mannitol, xylitol, erythritol, maltol, maltose, lactose, fructose oligosaccharides, Fructus Momordicae, stevioside, acesulfame, aspartame, sucralose, glucide, xylose, arabinose, levulose, dextrinose, ribose and composition thereof.Preferably include xylitol, erythritol, fructose oligosaccharides, Fructus Momordicae, stevioside, acesulfame, sucralose and composition thereof.More preferably comprise erythritol, fructose oligosaccharides, Fructus Momordicae, acesulfame, sucralose and composition thereof.But as described below, in some embodiments of the present invention, this compositions does not preferably comprise aspartame.

Naturally occurring sweeting agent or their purified extract, for example (for example people such as Fischer obtains Patent right U.S. Patent No. 5 July 18 nineteen ninety-five for stevioside, protein sweetening agent thaumati, Fructus Momordicae, described in 433,965) etc. can be used as the sweeting agent here.

The mixture of fructose-oligosaccharide that preferred fructose-oligosaccharide is made up of the fructose strand that links to each other with sucrose molecule.First-selection, their mildew making sugar (nystose) is about 40: 50: 10 with the ratio of ketose and fructosyl-mildew making sugar (fructosyl-nystose), in the weight of compositions.Preferred fructose-oligosaccharide can carry out enzyme to sucrose by transfructosylase and be used for obtaining, and for example, can obtain from Beghin-Meiji Industries (Neuilly-sur-Seine, France).

Other non-limiting instance of this class sweeting agent comprises polyhydric alcohol, because they can provide the effect of sugar but not have heat and blood sugar content is not provided, is preferred therefore.Therefore, polyhydric alcohol is specially adapted to the increase of blood sugar control and insulin content.The non-limiting example of the known polyhydric alcohol of this purposes comprises erythritol, mannitol, hydroxyl isomaltulose, lactose, maltose alcohol, Sorbitol and xylitol.

Erythritol is particularly preferred here sweeting agent.Erythritol is the polyhydric alcohol of the body sweeting agent (bulk sweetener) that is used as low-calorie diet usually.Erythritol provides with respect to " sugariness " of sucrose about 70% with respect to the heat of sucrose about 5%.In the U.S., erythritol is generally designated as about 0.2 calorie of every gram.Similarly, mannitol, hydroxyl isomaltulose, lactose, maltose alcohol, Sorbitol and/or xylitol can be used for this compositions with effect that traditional saccharide is provided and have very low calorie intake and the blood glucose contribution.

Sucralose also is specially adapted to this.It has very little of not influence to metabolism, blood sugar increasing or the insulin generation of sugar or carbohydrate.It for example can be available from New Brunswick, the McNeil Specialty Products Company company of NewJersey.

Other non-limitative example that does not have hot sweeting agent comprises aspartame; glucide; cyclamate; acesulfame K; L-aspartyl-L-phenylalanine lower alkyl esters sweeting agent; L-aspartyl-D-aminopropanamide; as United States Patent (USP) 4 people such as nineteen eighty-three mandate Brennan; 411; introduce in No. 925; L-aspartyl-D-silk amide; as United States Patent (USP) 4 people such as nineteen eighty-three mandate Brennan; 399; introduce in No. 163; L-aspartyl-methylol alkanamides sweeting agent is as authorizing the United States Patent (USP) 4,338 of Brand in nineteen eighty-two; introduce in 346; L-aspartyl-1-ethoxy alkanamides sweeting agent is as authorizing the United States Patent (USP) 4,423 of Rizzi in nineteen eighty-three; introduce glycyrrhizin and synthetic alkoxyl fragrance hydrocarbon in No. 029.

But in the certain embodiment of the present invention, aspartame is not preferred employing.Therefore, in these embodiments, the essentially no aspartame of this compositions.The term " essentially no " of relevant herein aspartame be meant this compositions comprise be lower than composition weight about 0.5%, more preferably less than about 0.25%, more preferably less than about 0.1% and first-selectedly be lower than about 0.01% aspartame.

Usually, the amount of this compositions sweeting agent depends on the particular sweetener of employing and required sweetness intensities.Usually, this compositions comprises total sweeting agent of about 0.00001%-about 75% of composition weight.Dry type beverage composition for treating dental erosion (be suitable for dilution so that concentrate or ready-to-drink beverage compositions to be provided) usually comprises about 75%, about 65%, preferred about 60%, the total sweeting agent of 20%-about 55% most preferably from about of about 10%-also of 5%-more preferably from about of about 0.0001%-of compositions (being the dry type beverage composition for treating dental erosion) weight.Be suitable for diluting with the concentrate that ready-to-drink beverage compositions is provided and usually comprise about 75%, more preferably about 40%, the total sweeting agent of 5%-about 30% most preferably from about of about 50%, the also preferred about 2%-of 1%-of about 0.0001%-of compositions (i.e. this concentrate) weight.Ready-to-drink beverage compositions usually comprises about 50%, about 10%, the total sweeting agent of 0.25%-about 5% most preferably from about of about 25%, the also preferred about 0.01%-of 0.00l%-more preferably from about of about 0.0001%-of compositions (being ready-to-drink beverage compositions) weight.When adopting the mixture of sweeting agent, the relative weight percent of each sweeting agent provides the total sweet taste amount in the compositions on the whole.

The nonessential composition of this compositions

The present invention can be used for food, beverage, medicine, OTC (over-the-counter) and meals and augments compositions.Here especially preferred syrup arranged, be suitable for diluting, be suitable for diluting with powder or other dry type compositions that ready-to-drink beverage compositions is provided and promptly drink compositions with concentrate that ready-to-drink beverage compositions is provided.

Wherein, most preferably promptly drink compositions, also preferred dry type beverage composition for treating dental erosion and concentrate.The dry type beverage composition for treating dental erosion here is suitable for water or other liquid diluting to form concentrate or ready-to-drink beverage compositions.Here the term " dry type " that is used for beverage composition for treating dental erosion refers to that this compositions comprises and is lower than the about 5% of this dry type beverage composition for treating dental erosion weight, the water more preferably less than about 1%.

Here also be suitable for food compositions.Preferred food compositions comprises chewing gum, loaf sugar, soft sweet and other sweet goods product, bar shaped food (bar) (comprise " health " bar shaped food and bar shaped dessert) after meal, and other bakery product and tablespread.

Here also can adopt sheet shape, capsule, pill and other this class form.

The application different with these is consistent, and compositions herein can contain other nonessential composition for example to strengthen them in the performance that provides on articulation health, bone health, other health advantages, ideal trophic structure and/or the organoleptic properties.For example, can adopt one or more caloric sweeteners, omega-3-fatty acid, analeptic, flavonol, milk solids, soluble fiber, nutrient, flavoring agent, coloring agent, antiseptic, acidulant, emulsifying agent, thickening agent, oil, water, carbonating composition or the like.These nonessential compositions can be disperseed, dissolve or otherwise are mixed in this compositions.If they can significantly not hinder the character of beverage composition for treating dental erosion, particularly provide the character of joint and/or bone health, these compositions can be added in compositions herein.Below provide the non-limiting example of optional component.

Caloric sweeteners

As described here, significant advantage of the present invention has provided the compositions that comprises Chondroprotective agents, and said composition has been avoided high heat picked-up and/or hyperglycemic index.But this does not get rid of the more traditional caloric sweeteners of use, therefore can use one or more caloric sweeteners here, for example glucose, dextrose, sucrose and/or fructose.For example sucrose and/or fructose can combine with requirement of the present invention and use usually.

Fructose can be to obtain or provide with the form of liquid fructose, high-fructose corn syrup, dry fruit sugar or fructose syrup, but preferably provides with the form of high-fructose corn syrup.The product that is purchased of high-fructose corn syrup (HFCS) has HFCS-42, HFCS-55 and HFCS-90, and it contains the sugared solid of the fructose form of weight meter 42%, 55% and 90% respectively.Fructose also is present in the fruit juice, and preferred version of the present invention also comprises fruit juice.

But, under feasible situation, preferably use these caloric sweeteners, requirement condition of the present invention to allow this way still can provide the compositions of usefulness simultaneously less as far as possible.Therefore, this compositions can comprise the caloric sweeteners that is selected from glucose, dextrose, sucrose and fructose (more preferably being selected from sucrose and fructose).

Omega-3-fatty acid

In particularly preferred embodiment of the present invention, can in this compositions, add one or more omega-3-fatty acids.Omega-3-fatty acid is the anti-inflammatory compound as other competitive inhibitor of arachidonic acid-type.Omega-3-fatty acid is the precursor that synthesizes the prostaglandin that controls inflammation in mammal.Referring to as in December, 1998 No. 5,843,919, the United States Patent (USP) of authorizing Burger on the 1st.

Not necessarily be used for the combination that herein omega-3-fatty acid can be any omega-3-fatty acid or omega-3-fatty acid.The non-limitative example that is applicable to omega-3-fatty acid herein comprises eicosapentaenoic acid (being also referred to as EPA), docosahexenoic acid (being also referred to as DHA) and composition thereof.

Not necessarily, can omega-3-fatty acid described herein and other oil-soluble composition be added in this compositions by emulsifying and/or capsulation.In addition, doing basically in compositions, can be according to the method for generally knowing with the omega-3-fatty acid spray drying.

Can use one or more omega-3-fatty acids in this compositions, the ratio of first component herein and omega-3-fatty acid is very important usually for optimizing health advantages, particularly articulation health benefit, bone health benefit and antiinflammatory.Preferably, first component that exists in the compositions is about 95: 5 to about 5: 95 with the ratio (based on the ratio of weight with weight) of total omega-3-fatty acid, more preferably is about 75: 25 to about 25: 75, is most preferably about 60: 40 to about 40: 60.Thereby preferably be included in the dosage of the omega-3-fatty acid in the compositions according to these control indexes.The general dosage of first component above has been described in detail in detail.

Analeptic

As generally known in the art, can make analeptic by from natural origin, extracting maybe can synthesize.Anti-depressant non-limitative example comprises methylxanthine, as caffeine, theobromine and theophylline.In addition, separate or synthesized many other xanthine derivatives, can be used as analeptic in the compositions herein.Referring to Biochemical Pharmacology (" biochemical pharmacology ") the 30th volume as Bruns, 325-333 page or leaf (1981), wherein introduced xanthine especially, the 9-methylxanthine, heteroxanthine, the 3-methylxanthine, 3, the 7-dimethyl xanthine, 8-chloromethyl-3, the 7-dimethyl xanthine, 8-methylol-3, the 7-dimethyl xanthine, 3,7-diethyl xanthine, 3, two (2-ethoxy) xanthine of 7-, 3-propyl group-7-(dimethylaminoethyl) xanthine, the 1-methylxanthine, 1, the 9-dimethyl xanthine, 1-methyl-8-methyl sulfur purine, 8-phenyl-1-methylxanthine, 1, the 7-dimethyl xanthine, 1,7-dimethyl-8-oxygen xanthine, 1, the 3-dimethyl xanthine, 1,3, the 9-trimethyl xanthine, 8-fluorine theophylline, 8-Chlorotheophyline, 8-bromine theophylline, 8-sulfur theophylline, 8-methyl sulfur theophylline, 8-ethyl sulfur theophylline, 8-nitro theophylline, 8-methylamino theophylline, 8-dimethylamino theophylline, 8-methyl theophylline, 8-ethyl theophylline, 8-propyl group theophylline, 8-cyclopropyl theophylline, theophylline-8-propionic ester (ethyl ester), 8-benzyl theophylline, 8-cyclopenta theophylline, 8-cyclohexyl theophylline, 8-(3-indyl) theophylline, 8-phenyl theophylline, 9-methyl-8-phenyl theophylline, 8-(rubigan) theophylline, 8-(to bromophenyl) theophylline, 8-(p-methoxyphenyl) theophylline, 8-(p-nitrophenyl) theophylline, 8-(to dimethylamino phenyl) theophylline, 8-(p-methylphenyl) theophylline, 8-(3, the 4-Dichlorobenzene base) theophylline, 8-(m-nitro base) theophylline, 8-(ortho-nitrophenyl base) theophylline, 8-(adjacent carboxyl phenyl) theophylline, 8-(1-naphthyl) theophylline, 8-(2,6-dimethyl-4-hydroxyphenyl) theophylline, 7-methoxyl group-8-phenyl theophylline, 1,3, the 7-trimethyl xanthine, S-chlorine caffeine, S-oxygen caffeine, S-methoxyl group caffeine, S-methylamino caffeine, 8-lignocaine caffeine, 8-ethyl caffeine, 7-ethyl theophylline, 7-(2-chloroethyl) theophylline, 7-(2-ethoxy) theophylline, 7-(carboxymethyl) theophylline, 7-(carboxymethyl) theophylline (ethyl ester), 7-(2-hydroxypropyl) theophylline, 7-(2, the 3-dihydroxypropyl) theophylline, 7-b-D-ribofuranosyl theophylline, 7-(glyceropent-2-enopyranosyl) theophylline, 7-phenyl theophylline, 7,8-diphenyl theophylline, 1-methyl-3,7-diethyl xanthine, 1-methyl-3-isobutyl group xanthine, 1-ethyl-3, the 7-dimethyl xanthine, 1,3-diethyl xanthine, 1,3,7-triethyl group xanthine, 1-ethyl-3-propyl group-7-butyl-8-methylxanthine, 1,3-dipropyl xanthine, 1,3-diallyl xanthine, 1-butyl-3, the 7-dimethyl xanthine, 1-hexyl-3,7-dimethyl xanthine and 1-(5-oxygen hexyl)-3, the 7-dimethyl xanthine.

In addition, one or more these analeptic are present in as among coffee, tea, cola, cocoa, Ilex paraguarensis, yaupon, brazilian cocoa paste and the yoco.Natural plant extracts is preferred analeptic source, and because of it contains other chemical compound that can delay anti-depressant bioavailability, they can not have to provide mental restoration and agility under nervous or the jittery condition like this.

Most preferred methylxanthine is a caffeine.Caffeine can or can obtain by synthetic preparation from above-mentioned plant and garbage thereof.The preferred plant origin that can be used as the caffeine in all or part of caffeine source comprises green tea, brazilian cocoa, Ilex paraguarensis, black tea, cola, cocoa and coffee.As described here, green tea, brazilian cocoa, coffee and Ilex paraguarensis are the most preferred plant origin of caffeine, are most preferably green tea, brazilian cocoa and coffee.Ilex paraguarensis also has the effect of other appetite-suppressing, also can add for this purpose.The total amount of the caffeine in any embodiment of the present invention comprises the natural amount that is present in the caffeine of caffeine in tea extract, flavoring agent, plant and any other composition and any interpolation.

Any analeptic used herein preferably exists with the relevant content of physiology, and the meaning is that source used in practice of the present invention provides the amount safely and effectively that reaches the anagoge agility.

Doping in this compositions wherein, said composition preferably contain composition weight about 0.0005% to about 1%, more preferably about 0.003% to about 0.5% even more preferably about 0.003% to about 0.2% even more preferably about 0.005% to about analeptic of 0.05%, most preferably about 0.005% to about 0.02%.The technical staff will appreciate that certainly the anti-depressant actual amount of adding will depend on its biological effect, as the spiritual quick effect for consumer.

Flavonol

Flavonol is for being present in the natural materials in each kind of plant (as fruit, vegetable and flower).The flavonol that is used for the present invention can be by any proper method well known to those skilled in the art from as extracting fruit, vegetable, green tea or other natural origin.For example, be extracted as the common methods of from green tea, separating flavonol with ethyl acetate or chlorinated organic solvent.Can from single plant or various plants, extract flavonol.Many fruit, vegetable and spend in contain flavonol, but ratio content is lower mutually with green tea.Those skilled in the art knows the plant that contains flavonol.The example of the modal flavonol that extracts from other plant of Camellia sinensis and gambir (Ramulus Uncariae Cum Uncis section) comprises as catechuic acid, epicatechin, gallo catechin, epi-nutgall catechuic acid, epicatechin gallate and epi-nutgall catechuic acid gallate.

Being used for the form that the flavonol of all compositionss of the present invention can tea extract exists.Tea extract can extract from non-fermented tea, fermented tea, part fermented tea and composition thereof and obtain.Preferably, tea extract is to extract in the tea that never ferments and partly ferment to obtain.Most preferred tea extract comes from green tea.The extract of hot and cold all can be used among the present invention.The known suitable method that obtains tea extract.Referring to the United States Patent (USP) 5 of authorizing Ekanayake as on March 9th, 1999,879, No. 733, the United States Patent (USP) 4 of authorizing Tsai June nineteen ninety, 935, authorize No. 4,680,193, the United States Patent (USP) of Lunder and the United States Patent (USP) 4 of authorizing Creswick on May 26th, 1987 No. 256, in July, 1987,668, No. 525.

Preferred source of flavanols in the compositions of the present invention is a green tea.Wherein the flavonol that with green tea, particularly is present in the green tea adds in the beverage, it has been observed by the present inventors that flavonol at least in part with to delay anti-depressant bioavailability relevant, this helps to alleviate and/or eliminates general nervousness and the anxiety relevant with these analeptic.

Perhaps, can prepare these identical flavonol and add in this compositions by synthetic or other appropriate chemical methods.Can buy flavonol from market, comprise catechuic acid, epicatechin and derivant thereof.

The amount of the flavonol in the compositions of the present invention can change.But when using one or more flavonol, preferably use about 0.001% to about 5%, more preferably about 0.001% to about 2% even more preferably about 0.01% of composition weight to arrive about one or more flavonol of 1%, most preferably about 0.01% to about 0.05%.

Milk solids and other protein

Also one or more milk solids not necessarily can be included in the compositions of the present invention.Newborn base used herein is meant the breast that comes from one or more mammiferous breasts or plant origin, comprises the lactic acid beverage that obtains as fermentation milk, by lactate fermentation or alternate manner acidify, the milk product of sterilizing newborn base material, liquid milk and milk product such as defatted milk powder or whole milk powder or other powder type.Milk solids used herein is meant the solids content or the dry of newborn base material.

When using one or more milk solids, the ideal total content of the milk solids that calculates based on the milk solids of compositions of the present invention is generally about 0.001% to about 15%, is preferably about 0.005% to about 10%, is most preferably about 0.1% to about 5%.

Other protein also can be used for this compositions as Semen sojae atricolor, milk surum, caseinate and educt thereof.These proteinic each content can change, and this can easily be determined by those skilled in the art.

Soluble fiber

Can also randomly contain one or more soluble fibers in the compositions for use of the present invention so that for example nutritional benefits to be provided.The soluble fiber that can use or unite use in all embodiments of the present invention separately includes, but is not limited to pectin, Psyllium, guar gum, xanthan gum, alginate, Radix Acaciae senegalis, fructose-oligosaccharide, inulin, agar and carrageenin.At least a in guar gum, xanthan gum and the carrageenin preferably wherein, most preferably at least a in guar gum and the xanthan gum.These soluble fibers can also play function of stabilizer in various embodiments of the present invention.

Be applicable to that particularly preferred soluble fiber herein is the glucose polymer, be preferably glucose polymer with side chain.The soluble fiber of selling with trade name Fibersol2 that preferably can buy from the Itami city Matsutani Chemical Industry company of Japanese Hyogo in these soluble fiber.

Pectin and fructose-oligosaccharide also are the preferred soluble fibers of the present invention.More preferably, pectin and fructose-oligosaccharide are united use.Pectin and fructose-oligosaccharide preferably than being about 3: about 1: 3 of 1-, in the weight of compositions.Preferred pectin has and is higher than about 65% degree of esterification.

Preferred pectin extracts by hot acid from peel of Citrus reticulata Blanco and obtains, and can derive from, for example Danisco Co. (Braband, Denmark).

When using soluble fiber, the desirable total amount of solvable dietary fiber that is used for the present composition is about 15% for about 0.01%-, and preferably about 0.1%-is about 5%, and more preferably 0.1%-is about 3%, first-selection about 0.2%-about 2%.

Nutrient

Compositions of the present invention can be optionally but is preferably strengthened with one or more nutrients, especially one or more vitamin and/or mineral in addition.Recommend to define in meals allowance standard every day-national science association-the National Research Council's food and the Food ﹠ Nutrition Department (Food and NutritionBoard, National Academy of Sciences-National Research Council) and listed about the U.S. of vitamin and mineral and recommended intake standard every day (USRDI).

Unless other explanation is arranged herein, when having the mineral of regulation in the compositions, then generally contain at least about 1% in the compositions, preferably at least about 5%, about 200%, this mineral of 40%-about 150% and the about 125%USRDI of first-selected about 60%-more preferably from about of 10%-more preferably from about.Unless other explanation is arranged herein, when having the vitamin of regulation in the compositions, then contain at least about 1% in the compositions, preferably at least about 5%, about 200%, this vitamin of 20%-about 150% and the about 120%USRDI of first-selected about 25%-more preferably from about of 10%-more preferably from about.

The non-limiting example of this additional vitamins and mineral comprises nicotinic acid, thiamine, folic acid, pantothenic acid, biotin, vitamin A, vitamin C, vitamin B2, vitamin B3, vitamin B6, vitamin B12, vitamin D, vitamin E and vitamin K, ferrum, zinc, copper, phosphorus, iodine, chromium, molybdenum and fluoride.Preferably, when using additional vitamins or mineral, vitamin or mineral are selected from nicotinic acid, thiamine, folic acid, iodine, vitamin A, vitamin C, vitamin B6, vitamin B12, vitamin D, vitamin E, ferrum, zinc and calcium.Preferably, at least a vitamin is selected from vitamin C, vitamin B6, vitamin B12, vitamin E, pantothenic acid, nicotinic acid and biotin.This compositions also preferably comprises vitamin C and one or more are selected from other vitamin of vitamin B6, vitamin B12, vitamin E, pantothenic acid, nicotinic acid or biotin.

The vitamin a source that also can contain commercially available acquisition in this compositions." vitamin A " used herein includes, but is not limited to vitamin A, beta-carotene, retinol cetylate and retinyl acetate.Vitamin A can be, for example, and any form of oil, pearl (beadlets) or capsulation.When having vitamin A in the compositions of the present invention, then contain at least about 1% in the compositions, preferably at least about 5%, about 200%, this vitamin of 15%-about 150% and the about 120%USRDI of first-selected about 20%-more preferably from about of 10%-more preferably from about.When having vitamin A in the compositions of the present invention, especially preferably contain the vitamin A of the 25%USRDI that has an appointment.The desire addition of vitamin A depends on processing conditions and the conveying capacity of required vitamin A after storing.Preferably, when containing vitamin A in the compositions of the present invention, contain about 0.2%, about 0.1%, the vitamin A of 0.0005%-about 0.08% and first-selection about 0.001%-about 0.06% more preferably from about of about 0.12%, the also preferred about 0.0003%-of 0.0002%-more preferably from about of the about 0.0001%-of its weight in the compositions.

Also can use the source of the commercially available acquisition of vitamin B2 (being also referred to as riboflavin) in this compositions.When having vitamin B2 in the compositions of the present invention, contain at least about 1% in the compositions, preferably at least about 5%, about 200%, this vitamin of 10%-about 150% and the about 120%USRDI of first-selected about 10%-more preferably from about of 5%-more preferably from about.When having vitamin B2 in the compositions of the present invention, especially preferably contain the vitamin B2 of the about 35%USRDI of 15%-that has an appointment.

Vitamin C (ascorbic acid) is for being used for particularly preferred nonessential composition herein.Without being limited by theory, it has been generally acknowledged that vitamin C can be used to strengthen benefits herein by the cofactor of the enzyme that is used as crosslinked with collagen.

Also can use the ascorbic acid of capsulation and the edible salt of ascorbic acid.When having vitamin C in the compositions of the present invention, contain at least about 1% in the compositions, preferably at least about 5%, about 200%, this vitamin of 20%-about 150% and the about 120%USRDI of first-selected about 25%-more preferably from about of 10%-more preferably from about.When having vitamin C in the compositions of the present invention, especially preferably contain the vitamin C of the 100%USRDI that has an appointment.Ascorbic desire addition depends on processing conditions and required ascorbic conveying capacity after storing.Preferably, when containing vitamin C in this compositions, contain about 0.2%, about 0.1%, the vitamin C of 0.02%-about 0.08% and first-selection about 0.03%-about 0.06% more preferably from about of about 0.12%, the also preferred about 0.02%-of 0.01%-more preferably from about of the about 0.005%-of its weight in the compositions.

Other vitamin that can be spiked into the nutrition amount of augmenting among the present invention includes, but is not limited to vitamin B6 and B12, folic acid, nicotinic acid, pantothenic acid, folic acid, vitamin D and vitamin E.During a kind of in containing these vitamin in the compositions, compositions preferably contains at least 5%, preferred at least 25% and the first-selected this vitamin of 35%USRDI at least.

Can not necessarily be included in mineral in the compositions herein just like calcium, manganese, magnesium, boron, zinc, iodine, ferrum and copper.Mineral can be as salt, chelating, compound or colloidal form.

Can use any soluble-salt of these mineral that are suitable for being contained in edible composition, as magnesium citrate, gluconic acid magnesium, magnesium sulfate, zinc chloride, zinc sulfate, potassium iodide, copper sulfate, copper gluconate and copper citrate.

Because manganese participates in the synthetic of glucosaminoglycan, collagen and glycoprotein, manganese is the particularly preferred mineral that is used for herein.In addition, manganese deficiency can cause unusual osteogenesis, inflamed joints, bone loss and arthritis.Manganese ascorbate is the form that is used for particularly preferred manganese herein.For people or large mammal (as horse), general manganese dosage arrives about 1000mg for about 0mg, more preferably for about 50mg arrives about 950mg, is most preferably about 50mg to about 250mg.

Because form the essential boron of Bone Gla protein in bone, boron is the particularly preferred mineral that is used for herein.

Calcium is for can be used for particularly preferred mineral of the present invention.Preferred sources of calcium comprises as calcium amino acid chelate, calcium carbonate, calcium oxide, calcium hydroxide, calcium sulfate, calcium chloride, calcium phosphate, calcium hydrogen phosphate, dalcium biphosphate, calcium citrate, calcium malate, calcium titrate, calcium gluconate, calcium realate, Calcium d-tartrate and calcium lactate, particularly citric acid-calcium malate.At United States Patent (USP) the 5th as people such as JIUYUE in 1997 mandate on the 23rd Mehansho, 670, No. 344, people's such as mandate on March 18th, 1997 Diehl United States Patent (USP) the 5th, 612, No. 026, people's such as mandate on November 5th, 1996 Andon United States Patent (USP) the 5th, 571, No. 441, people's such as nineteen ninety-five December mandate on the 12nd Meyer United States Patent (USP) the 5th, 474, No. 793, people's such as mandate on November 21 nineteen ninety-five Andon United States Patent (USP) the 5th, 468, No. 506, people's such as mandate on August 29 nineteen ninety-five Burkes United States Patent (USP) the 5th, 445, No. 837, people's such as mandate on June 13 nineteen ninety-five Dake United States Patent (USP) the 5th, 424, No. 082, people's such as mandate on June 6 nineteen ninety-five Burkes United States Patent (USP) the 5th, 422, No. 128, people's such as mandate on March 28 nineteen ninety-five Burkes United States Patent (USP) the 5th, 401, No. 524, people's such as mandate on February 14 nineteen ninety-five Zuniga United States Patent (USP) the 5th, 389, No. 387, authorized the United States Patent (USP) the 5th of Jacobs on May 24th, 1994,314, No. 919, people's such as mandate on August 3rd, 1993 Saltman United States Patent (USP) the 5th, 232, No. 709, people's such as mandate on July 6th, 1993 Camden United States Patent (USP) the 5th, 225, No. 221, people's such as mandate on June 1st, 1993 Fox United States Patent (USP) the 5th, 215, No. 769, people's such as mandate on February 16th, 1993 Fox United States Patent (USP) the 5th, 186, No. 965, people's such as JIUYUE in 1992 mandate on the 29th Saltman United States Patent (USP) the 5th, 151, No. 274, authorized the United States Patent (USP) the 5th of Kochanowski on July 7th, 1992,128, No. 374, people's such as mandate on June 2nd, 1992 Mehansho United States Patent (USP) the 5th, 118, No. 513, people's such as mandate on April 28th, 1992 Andon United States Patent (USP) the 5th, 108, No. 761, people's such as mandate on February 19th, 1991 Mehansho United States Patent (USP) the 4th, 994, No. 283, people's such as mandate on November 22nd, 1988 Nakel United States Patent (USP) the 4th, 786, authorize the form of having introduced citric acid-calcium malate in people's such as Nakel No. the 4th, 737,375, the United States Patent (USP) in No. 510 and on April 12nd, 1988.Preferred compositions of the present invention contains about 0.01% to about 0.5%, more preferably about 0.03% to about 0.2% even more preferably about 0.05% of composition weight and arrives about calcium of 0.15%, most preferably about 0.1% to about 0.15%.

Ferrum also can be used for the compositions and methods of the invention.The form accepted of ferrum is well known in the art.The amount that is spiked into the iron compound in the compositions depend on the required magnitude of recruitment of final composition and at consumer and change widely.Generally contain about 100%, the preferred ferrum of about 15%-about 50% and the about 40%USRDI of the about 20%-of first-selection of the 5%-that has an appointment in the compositions that ferrum of the present invention is strengthened.

The ferrum of ferrous form is better utilized by human body than the ferrum of ferric form.The mixture that the high biological utilisation ferrous salt that can use in the compositions of ingesting of the present invention is ferrous sulfate, ferrous fumarate, ferrous succinate, Ferrous gluconate, ferrous lactate, ferrous tartrate, ferrous citrate, amino acid ferrous chelate compound and these ferrous salt.Although the ferrum of ferrous form is more bioavailable in general, some trivalent iron salt also can provide the high biological utilisation source of ferrum.The mixture that the high biological utilisation trivalent iron salt that can use in Foods or drinks compositions of the present invention is saccharic acid ferrum, ferric ammonium citrate, ferric citrate, iron sulfate and these trivalent iron salts.Can in these edible compounds and instant beverage, use high biological utilisation ferrous salt and ferric combination or mixture.The preferred source of high biological utilisation ferrum is ferrous fumarate and amino acid ferrous chelate compound.

The amino acid ferrous chelate compound that is particularly suitable as the used high biological utilisation source of iron of the present invention is to have ligand/metal than the chemical compound that is at least 2: 1.For example, have ligand and have following formula than the suitable amino acid ferrous chelate compound that is 2 with metal molar:

Fe (L) ₂Wherein L is a-amino acid, dipeptides, tripeptides or tetrapeptide ligand.Thus, L can be any ligand of naturally occurring a-amino acid or these a-amino acids dipeptides, tripeptides or the tetrapeptide that form by any combination, and wherein said a-amino acid is selected from alanine, arginine, agedoite, aspartic acid, cysteine, cystine, glutamine, glutamic acid, glycine, histidine, hydroxyproline, isoleucine, leucine, lysine, methionine, ornithine, phenylalanine, proline, serine, threonine, tryptophan, tyrosine and valine.For example referring to, Ashmead etc.US patent 4,863,898 (1989.9.5 mandate); AshmeadUS patent 4,830,716 (1989.5.16 mandate) and AshmeadUS patent 4,599,152 (1986.7.8 mandate), all these patents all are incorporated herein by reference.Particularly preferred amino acid ferrous chelate compound is that wherein reactive ligand is glycine, lysine and leucic chelate.First-selected is the amino acid ferrous chelate compound (Albion Laboratories, salt lake city, the Utah State) that trade mark is sold with FERROCHEL, and ligand wherein is a glycine.

Except that these high biological utilisation ferrous salt and trivalent iron salt, other source of biological utilisation ferrum also can be included in the Food ﹠ Drink compositions of the present invention.Other source that is particularly suitable for strengthening the ferrum of the present composition comprises some ferrum-sugar-carboxylate complex.In these ferrum-sugar-carboxylate complex, carboxylate radical is that ferrous (preferably) or ferric iron provide counter ion counterionsl gegenions.Whole building-up processes of these ferrum-sugar-carboxylate complex are included in and form in the water-bearing media that calcium-sugared structure division (for example, by calcium hydroxide and sugar are reacted), with source of iron (as Ferrous ammonium sulfate) therewith calcium-sugared structure division in water-bearing media, react and obtain ferrum-sugared structure division, and, obtain required ferrum-sugar-carboxylate complex with carboxylic acid (" carboxylate radical counter ion counterionsl gegenions ") this reaction system that neutralizes.But the steamed bun stuffed with sugar that can be used for preparing calcium-sugared structure division is drawn together any sugar material and composition thereof, as glucose, sucrose and fructose, mannose, galactose, lactose, maltose or the like, is more preferably sucrose and fructose.It can be any carboxylic acid of ingesting that the carboxylic acid of " carboxylate radical counter ion counterionsl gegenions " usefulness is provided, as citric acid, malic acid, tartaric acid, lactic acid, succinic acid, propanoic acid etc. and these sour mixture.

These ferrum-sugar-carboxylate complex can prepare according to the mode described in the following document, for example, Nakel etc.US patent 4,786,510 and 4,786,518 (1988.11.22 mandates), these two pieces are incorporated herein by reference.These materials are known as " complex ", but they can the form with protecting colloid complexity, high degree of hydration exist in solution; Using term " complex " is for simplicity.

Can also use zinc in the compositions and methods of the invention.The form accepted of zinc is well known in the art.Generally contain about 100%, the preferred zinc of about 15%-about 50% and the about 45%USRDI of the about 25%-of first-selection of the 5%-that has an appointment in the compositions that zinc of the present invention is strengthened.The zinc compound that can use in the present invention can be any common version, for example, and the zinc and the zinc oxide of zinc sulfate, zinc chloride, zinc acetate, zinc gluconate, ascorbic acid zinc, zinc citrate, aspartic acid zinc, selenium picolinate, chelating amino acids.The zinc of zinc gluconate and chelating amino acids is particularly preferred.

Flavoring agent

Recommend in embodiments of the invention to use one or more flavoring agent, to strengthen its delicious food.Any natural or synthetic flavoring agent can be used for the present invention.For example, this compositions height preferably comprises fruit juice.Also preferably comprise one or more plants and/or fruit flavor agent.Therefore, this flavoring agent also comprises the mixture of various flavoring agent.These flavoring agent used herein can be synthetic or natural flavoring agent.

Here can be incorporated into any fruit juice and/or fruit juice concentrates, the fruit juice that for example comprises the female Citrus aurantium Linn. of Fructus Mali pumilae, Fructus Fragariae Ananssae, Fructus Citri Limoniae, grapefruit, Fructus actinidiae chinensis, Lay, Fructus Vitis viniferae, red Fructus Citri tangerinae, Fructus Citri junoris, Fructus Pruni pseudocerasi, Fructus Rubi, Cranberries fruit, Fructus Persicae, Citrullus vulgaris, passionfruit, Fructus Ananadis comosi, Fructus Mangifera Indicae, cupuacu, Fructus psidii guajavae immaturus, cocoa, Fructus Chaenomelis and Fructus Pruni, and composition thereof (as Cranberries fruit and Fructus Mali pumilae).In particularly preferred embodiments, contain in the compositions its weight greater than 0%, more preferably at least about 5%, about 40%, the fruit juice of 5%-about 30% most preferably from about of about 60%, the also preferred about 5%-of 5%-more preferably from about.

Also can use fruit flavor agent.Particularly preferred fruit flavor agent is Fructus Mali pumilae, Fructus Fragariae Ananssae, Fructus Citri Limoniae, grapefruit, Fructus actinidiae chinensis, the female Citrus aurantium Linn. of Lay, Fructus Vitis viniferae, red Fructus Citri tangerinae, Fructus Citri junoris, Fructus Pruni pseudocerasi, Fructus Rubi, Cranberries fruit, Fructus Persicae, Citrullus vulgaris etc., and composition thereof.The mixture of flavoring agent (as red Fructus Citri tangerinae-Fructus Citri junoris) most preferably.Also can adopt external lactone flavoring agent, as passionfruit, Fructus Ananadis comosi, Fructus Mangifera Indicae, cupuacu, Fructus psidii guajavae immaturus, cocoa, Fructus Chaenomelis and Fructus Pruni, and composition thereof.These fruit flavor agents can come from natural origin such as fruit juice and local flavor oil, perhaps can be by synthetic preparation.

Preferred botanical flavors comprises as tea (preferably black tea and green tea, green tea most preferably), Aloe, brazilian cocoa, Radix Ginseng, Semen Ginkgo (ginkgo), Fructus Crataegi, Hibiscus, Rosehips, Chamomile, Herba Menthae, Fructus Foeniculi, Rhizoma Zingiberis Recens, Radix Glycyrrhizae, Semen Nelumbinis, Schizandra, GAIWUZONGLV (sawpalmetto), Rhizoma Smilacis Chinensis, Flos Carthami, St. John's Wort, Rhizoma Curcumae Longae, cardimom, Semen Myristicae, Cortex cinnamomi japonici (Ramulus Cinnamomi), cloth is withered, Cortex Cinnamomi, jasmine, haw berry, Flos Chrysanthemi, Corm Eleocharitis, sugar cane, Fructus Litchi, bamboo sprout, Rhizoma et radix valerianae, coffee or the like.Preferably tea, brazilian cocoa, Radix Ginseng, Semen Ginkgo and coffee in these.Especially, tea flavoring agent, preferably green tea or black tea flavoring agent (preferably green tea) and not necessarily have pleasant taste with the combination of fruit flavor agent.In another embodiment preferred, in this compositions, added coffee.The combination of green tea and coffee also is preferred usually in this compositions.

If desired, the spice in the flavoring agent can be formed in the emulsion droplets, then emulsion droplets be dispersed in beverage composition for treating dental erosion or the concentrate.Because the proportion of these emulsion droplets is generally little thereby can form independent phase than water, available weighting agent (also as suspension) keeps being dispersed in the emulsion droplets in beverage composition for treating dental erosion or the concentrate.The example of these weighting agents has brominated vegetable oil (BVO) and resin ester, particularly fat glue.About use the more introduction of weighting agent and suspension in liquid beverage, referring to " development of soft drink technology " the 1st volume of L.F.Green, applied science is published company limited, 87-93 page or leaf (1978).Usually, flavoring agent usually can concentrate or extract or obtain with the form of the synthetic seasoning ester that makes, alcohol, aldehyde, terpenes, sesquiterpene or the like. Coloring agent

Can use a spot of one or more coloring agent in the compositions of the present invention.The preferred FD﹠amp that uses; C dyestuff (for example, #5 yellow, #2 blueness, #40 redness) and/or FD﹠amp; The C color lake.By the color lake being added in other powdery batching, all granules, particularly with the iron compound of color all by fully and painted equably, and obtain evenly painted beverage blends material.Can be used for preferred lake colours of the present invention is color lakes of FDA approval, as color lake #40 redness, #6 yellow, #1 blueness or the like.In addition, can be with FD﹠amp; C dyestuff or FD﹠amp; C lake colours and other general food and food color are united use.Also can use riboflavin and b-carotene.In addition, can use other natural colorant, for example comprise fruit, vegetable and/or plant extract, as Fructus Vitis viniferae, black currant, black gland arteries and veins wood genus, Radix Dauci Sativae, Radix Betae, red cabbage and Hibiscus.

The use amount of coloring agent will depend on used coloring agent and the required intensity of final composition and decide.Those skilled in the art determine this consumption easily.As a rule, if you are using, the amount of coloring agent should be that about 0.0001%-of composition weight is about 0.5%, and preferably about 0.001%-is about 0.1%, and first-selected about 0.004%-about 0.1%. Antiseptic

Not necessarily, the present invention can add and use one or more preservative systems.Preferably antiseptic comprises, for example, and sorbate, benzoate and Quadrafos antiseptic.

Preferably, when using antiseptic, use one or more sorbates or benzoate antiseptic (or its mixture).The sorbate and the benzoate antiseptic that are fit to use in the present invention comprise sorbic acid, benzoic acid and salt thereof, include, but is not limited to calcium sorbate, sodium sorbate, potassium sorbate, calcium benzoate, sodium benzoate, Potassium Benzoate and composition thereof.The sorbate antiseptic is particularly preferred.Potassium sorbate is particularly preferably in using among the present invention.

When compositions contains antiseptic, the antiseptic that preferably contains the about 0.0005%-of composition weight about 0.5% in the compositions of the present invention, more preferably from about 0.001%-about 0.4%, more preferably from about 0.001%-about 0.1%, more preferably from about 0.001%-is about 0.05%, the antiseptic of first-selected about 0.003%-about 0.03%.When compositions contained the mixture of one or more antiseptic, the total concentration of antiseptic preferably remained in these scopes.

Acidulant

If desired, this compositions can not necessarily comprise one or more acidulant.The amount of acidulant can be used for keeping the pH value of compositions.This compositions preferably has about 2 to about 10, and more preferably from about 2 to about 7, and preferred about 2 to about 5 again, more preferred about 3 to about 5 and most preferably from about 3.5 to about 4.5 pH value.The acidity of beverage can be adjusted to by known and conventional method and maintain in the scope of requirement, for example uses one or more above-mentioned acidulant.Usually the acidity in above-mentioned scope is to be in the MAC that suppresses microorganism and balance between the optimum acidity of required beverage flavor is provided.

Can adopt pH value organic and inorganic edible acids adjusting beverage, they can be to add except the sour share as described second component of part of the present invention.This acid can exist with the form of their unassociated forms or their salt separately, for example potassium phosphate,monobasic or sodium, potassium dihydrogen phosphate or sodium.Preferred acid is edible organic acid, and it comprises citric acid, malic acid, fumaric acid, adipic acid, phosphoric acid, gluconic acid, tartaric acid, ascorbic acid, acetic acid, phosphoric acid or its mixture.Most preferred acid is citric acid and malic acid.

This acidulant also can be used as antioxidant with the stable beverage component.Usually the antioxidant example that adopts includes but not limited to ascorbic acid, EDTA (ethylenediaminetetraacetic acid) and salt thereof.

Emulsifying agent and oil

For the purpose of structure and opacity, also can add one or more emulsifying agents and/or oil in this compositions.Be applicable to that herein general emulsifying agent and oil comprise as single acid/Diglyceride, lecithin, pulp, Oleum Gossypii semen and vegetable oil.

Thickening agent

One or more thickening agents can not necessarily be added in this compositions, for example are used to control viscosity and/or quality.Well known various thickening agent.The non-limiting example of thickening agent comprises cellulosic cpd, ghatti gum, modification ghatti gum, xanthan gum, tragacanth gum, guar gum, Gellan gum, locust bean gum, pectin and chemical compound thereof.For example authorize people's such as Kupper U.S. Patent No. 4,705,691 referring on November 10th, 1987.Here especially preferred thickening agent comprises xanthan gum, Gellan gum, guar gum and cellulosic cpd.

Cellulosic cpd is well known in the art.Cellulosic cpd generally is the anionic polymer by cellulose-derived.Here the non-limiting example of the cellulosic cpd of Cai Yonging comprises carboxymethyl cellulose, methylcellulose and hydroxyethyl-cellulose, hydroxypropyl cellulose.The most preferred cellulosic cpd of this compositions is a carboxymethyl cellulose, especially sodium carboxymethyl cellulose.The non-limiting example of cellulosic cpd comprises available from Wilmington, and the Hercules of Delaware, the trade mark of Inc. are the sodium carboxymethyl cellulose of Aqualon  7HOF.

When existing, the general consumption of this thickening agent in this compositions is about 10%, about 1%, more preferably from about 0.01%-about 0.2% and the first-selection about 0.02%-about 0.05% of about 5%, the also preferred about 0.00001%-of 0.00001%-more preferably from about of preferred about 0.00001%-of composition weight. Water

This compositions can and preferably comprise water.Most preferably water is included in the beverage composition for treating dental erosion embodiment of the present invention.When water is included in this compositions, compositions preferably contains the water at least about 10%, more preferably contains the water at least about 20%, even more preferably contains the water at least about 40%, even more preferably contain water at least about 75%, most preferably contain water at least about 80%.In addition, usually, this ready-to-drink beverage compositions contains the water at least about 80% to about 99.9%.Beverage concentrates generally contains the water at least about 10%, more preferably contains the water at least about 20%, even more preferably contains the water at least about 25%.Here the term " dry type " that is used for beverage composition for treating dental erosion refers to that this compositions comprises and is lower than the about 5% of this dry type beverage composition for treating dental erosion weight, the water more preferably less than about 1%.Here, the water of said composition comprises water and any for example water in the fruit juice of knot and component that is present in of all interpolations. The carbonating segmentation

Can perhaps introduce in beverage composition after dilution in carbon dioxide introducing and the blended water of beverage concentrates, reach carbonating.The beverage of carbonating can be put into container, in bottle or jar, and sealing then.Can use the carbonating process of any routine to make carbonated beverages compositions of the present invention.The amount of introducing the carbon dioxide in the beverage depends on used particular flavor system and required carbonating degree.

Preparation method

This compositions is to prepare according to the method that those of ordinary skill is all known.In order to illustrate, compositions of the present invention can be dissolved in water, disperse or in independent mode or with suitable combination all the components is mixed in together by under the agitation as appropriate of mechanical agitator, all dissolves or dispersion fully up to all compositions.In the time of suitable, can subsequently all independent solution and dispersion liquid be mixed in together.When the tea extract that uses generally the pH sensitivity, regulating the pH value that needs with acidulant and/or buffer system before this tea extract is joined mixture may be very important.When needing the compositions of anti-storage, final mixture can be not necessarily but is preferably pasteurized or charging sterilely under suitable process condition.

For the compositions of preparation beverage, can at first not necessarily make beverage concentrates.A method of the concentrate form of preparation beverage composition for treating dental erosion is to start from the preparation beverage composition for treating dental erosion to use the water that is less than requirement.Another method be will be finally any other the volatile liquid of beverage composition for treating dental erosion partial dehydration only to remove a part of water and to exist of preparation.Can realize dehydration according to evaporation under well-known method such as the vacuum.Concentrate can be the form of more condensed liquid.Usually can form syrup by in beverage concentrates, adding suitable composition such as electrolyte or latex.Mixed syrup and water then to form finished beverage or finished beverage concentrate.Water and syrupy weight ratio were generally about 1: 1 to about 5: 1.

Can add carbon dioxide in the entry with mixed, perhaps add in the potable beverage composition for treating dental erosion, to reach carbonating with beverage concentrates.Then carbonated beverage composition for treating dental erosion is stored in sealing then in the proper container.In following list of references, introduced " soft drink process progress " the 1st volume (Elsevier, 1978) of the method for preparing soda pop embodiment of the present invention: L.F.Green (editor); " preparation and the processing of fruit juice, excited beverage and wine " of G.S.Cattell and P.M.Davies " milk product technology association magazine " the 38th volume (1), the 21-27 page or leaf; " beverage-technology, chemistry and the microbiology " of A.H.Varnam and J.P.Sutherland, Chapman Hall, 1994; And A.J.Mitchell (editor) " prescription of carbonated soft drink and production ", Blackie and Sons company limited, nineteen ninety.

The compositions that the dried component of all requirements by mixing appropriate amount and ratio can prepare dry composition of the present invention or do basically.Perhaps, the beverage composition for treating dental erosion of final preparation can be through dehydration to provide dried beverage composition for treating dental erosion of the present invention.Dried beverage composition for treating dental erosion for example is powdery, graininess or lamellar, can be dissolved in the water of appropriate amount or other later on and fill carbonic acid or do not fill in the liquid of carbonic acid so that beverage concentrates or ready-to-drink beverage compositions to be provided.Perhaps, dried forms product of the present invention can be incorporated in other compositions, includes but not limited to corn bar shaped food, breakfast bar shaped food, energy bar shaped food and nutrition bar shaped food.

Other exsiccant basically compositions comprises for example tablet, capsule, granule and dry powder.Tablet can comprise suitable adhesive, lubricant, diluent, disintegrating agent, coloring agent, flavoring agent, fluidizer and fusing agent.Can be used for preparing the suitable carrier of dry form product of the present invention and the U.S. Patent No. 3,903,297 that excipient for example is described in JIUYUE in 1975 mandate on the 2nd Rober.The technology and the compositions that are used for preparing the dry form product that is applicable to method of the present invention are described in the following document: H.W.Houghton (editor), Developments in Soft DrinksTechnology, Vol.3, Chapter 6, (Elservier, 1984); ModernPhamaceutics, Chaper 9 and 10 (Banker﹠amp; Rodes (editor), 1979); People's such as Liberman Phamaceutical Dosage Forms:Tablets (1981); And Ansel, Introduction to Phamaceutical Dosage Forms, the 2nd edition (1976).

Cover box of the present invention

The present composition can be used for cover box as herein described.Cover box of the present invention comprises one or more present compositions and relevant information, this information by literal, picture and or analog tell the user use this cover box will provide the healthy of one or more integral body and or whole physiological benefit, include but not limited to the articulation health benefit (comprise alleviate, prevent and/or suppress arthritis and or osteoarthritis and strengthen pliability), bone health benefit (comprise and keep and/or construct bone), antiinflammatory (for example easing the pain).Additionally or or, cover box of the present invention comprises one or more present compositions and relevant information, this information by literal, picture and or analog tell the user to use this cover box to be suitable for and/or to help suffering from the mammal (using) of diabetes for the mammal that suffers from diabetes.

In particularly preferred embodiments, information is imprinted on the container that compositions directly or indirectly is housed, on bottle.For example, these preferably overlap the form that box can be the single bottle that compositions is housed, and perhaps can be obtained by each a plurality of bottle that compositions is housed.For example, can obtain overlapping box by single bottle or common four, six, seven (as the supplys in a week) packaging together or the box of eight bottles.In addition, the cover box of every month usefulness can by as the box of common 28 or 30 bottles packaging together and obtaining.As non-limiting example, this information can be imprinted on the one bottle and/or contain on the packing material of bottle.

Here this information can be expressed by speech, picture, symbol and/or other visible description.These information needn't be used real word used herein, for example " joint ", " bone ", " mankind ", " mammal " or " diabetes ", but the speech, picture, symbol or the like of explaining identical or similar meaning are all within the scope of the invention.

Method of the present invention

Method of the present invention comprises allows the preferred human oral of mammal (promptly taking in) compositions of the present invention with treatment joint malfunction, bone malfunction and/or antiinflammatory.Preferably allow the mammal of standing joint and/or bone malfunction maybe need to keep the mammal of present joint and/or bone function (being preventive usage) to take compositions.Additionally or or, the mammal that is applicable to and/or helps suffering from diabetes by this compositions of sweeting agent that adopts definition here.The also additional picked-up that compositions of the present invention can be needed as normal diet.Do not limit the frequency of taking, but usually take weekly at least once, more preferably weekly at least 3 times, most preferably every day at least once.Take generally is persistence.

The term " oral " relevant with mammal (preferably people) used herein is meant for one or more purposes described here, comprise treatment joint malfunction, bone malfunction and/or antiinflammatory, mammal picked-up or quilt instruct picked-up one or more present compositions of the present invention.For example, this guidance can be verbal assistance (for example, by oral indication, for example, come from the doctor, fitness guru, sales engineer or tissue and/or radio or television medium are (promptly, oral indication) or written guidance (for example advertisement), by written guidance, for example, profit (for example comes from doctor or other fitness guru, hand-written prescription), sales engineer or tissue are (for example, by, for example, promote pamphlet, separate edition or other propaganda adnexa), written media (for example, the Internet, Email or other computer associated intermediary) and/or the package that is inconjunction with of compositions on (for example, be present on the packing that compositions is housed label).Herein, " written " is by speech, picture, symbol and/or other visual descriptor.These guidances needn't be used real word used herein, for example " joint ", " bone ", " mankind " or " mammal ", but comprise and make word, picture, symbol or the like, explain identical or similar implication within the scope of the invention.

Embodiment

Be the non-limiting example that adopts this compositions of conventional method preparation below.The following examples are provided for the present invention is described, do not expect to limit the scope of the invention by any way.

Embodiment 1

Be applicable to that dilution is prepared by following component so that the low in calories dried beverage composition for treating dental erosion of promptly drinking compositions to be provided.About 10 the gram dry compositions is packaged in the single part of parcel, be packaged in jointly then (for example dosage in a week) in the cover box that comprises 7 single part of parcels, it be easy to transport and be user-friendly to.Dried beverage composition for treating dental erosion can be by user's dilute with water to provide 230 milliliters ready-to-drink beverage compositions.

Two these cover boxes are obtained and are used as the dosage in 2 weeks by 50 years old diabetes women.This women's every day 1 dilute with water one bag parcel content and take the ready-to-drink beverage compositions of acquisition.After 2 weeks, this women reports the pain symptom alleviation and can finish various physical tasks more easily.In addition, this women can take said composition under situation about raising without any the blood sugar content that can aware.

Composition	Weight %
Composition	Weight %	Glucosamine hydrochloride	????17.75
Citric acid	????14.98	Glucosamine hydrochloride	????17.75
Citric acid	????14.98	Malic acid	????5.29
Calcium hydroxide	????5.85	Malic acid	????5.29
Calcium hydroxide	????5.85	Ascorbic acid	????0.81
Colorant	????0.2	Ascorbic acid	????0.81
Colorant	????0.2	Flavoring agent	????7.1
Xanthan gum	????0.49	Flavoring agent	????7.1
Xanthan gum	????0.49	The crystallization sucralose	????0.18
Erythritol	????47.34	The crystallization sucralose	????0.18

Embodiment 2

By with the mixed following ingredients of conventional method, prepared the i.e. beverage composition for treating dental erosion of drink low in calories, per 230 milliliters of these compositionss contain the total carbohydrates of 16 grams of having an appointment:

Composition	Weight %
Composition	Weight %	Ascorbic acid	????0.07
The EDTA calcium disodium	????0.003	Ascorbic acid	????0.07
The EDTA calcium disodium	????0.003	Calcium hydroxide	????0.25
Citric acid	????0.63	Calcium hydroxide	????0.25
Citric acid	????0.63	Erythritol	????2.0
Fructose	????2.0	Erythritol	????2.0
Fructose	????2.0	Glucosamine hydrochloride	????0.75
Malic acid	????0.22	Glucosamine hydrochloride	????0.75
Malic acid	????0.22	Sodium benzoate	????0.002
Sodium carboxy methyl cellulose	????0.03	Sodium benzoate	????0.002
Sodium carboxy methyl cellulose	????0.03	Sucralose (25%)	????0.03

Xanthan gum	????0.006
Xanthan gum	????0.006	Fruit juice concentrates	????2.0
Colorant	????0.007	Fruit juice concentrates	????2.0
Colorant	????0.007	Local flavor oil	????0.04
Water	In right amount	Local flavor oil	????0.04

Prepare the beverage composition for treating dental erosion of various local flavors, for example Fructus Citri junoris, grapefruit, Cranberries fruit and/or Cranberries fruit-Fructus Mali pumilae local flavor according to standard technique.

In the preferred embodiment of the invention, each 28 PET bottle that contain 8 ounces said composition is packaged in easily in the container (for example box) jointly.This can be used as the present composition of dosage in January.

This cover box obtains and is used as 1 month dosage by 60 years old male diabetes people.This male takes 1 bottle every day, takes altogether 28 days.In about 10 days of this cycle, this male can walk 1 mile every day, and knee does not have pain.In addition, this male can take said composition under situation about raising without any the blood sugar content that can aware, and keeps its body weight in this cycle.

Claims

1. compositions is characterized as:

B) except the sweeting agent of glucose, dextrose, sucrose and fructose; With

C) composition weight is at least about 10% water.

2. compositions is characterized as:

B) except the sweeting agent of glucose, dextrose, sucrose and fructose; The essentially no aspartame of compositions wherein.

3. compositions is characterized as:

A) be selected from gelatin, cartilage, amino sugar, glucosaminoglycan, methylsulfonyl methane, methylsulfonyl methane precursor, S-adenosylmethionine, its salt, and composition thereof Chondroprotective agents;

B) composition weight is at least about 10% water; With

C) per 230 milliliters of these compositionss are lower than the total carbohydrates of about 19 grams.

4. the compositions of any one during aforesaid right requires, wherein Chondroprotective agents be selected from amino sugar, glucosaminoglycan, S-adenosylmethionine, and composition thereof.

5. the compositions of any one during aforesaid right requires, wherein sweeting agent is selected from sorbitol, mannitol, xylitol, erythritol, maltol, maltose, lactose, fructose oligosaccharides, Fructus Momordicae, stevioside, acesulfame, aspartame, sucralose, glucide, xylose, arabinose, levulose, dextrinose and ribose.

6. the compositions of any one was characterised in that wherein at least a sweeting agent is selected from sucrose, fructose and composition thereof during aforesaid right required.

7. the compositions of any one during aforesaid right requires, wherein sweeting agent be selected from xylitol, erythritol, fructose oligosaccharides, Fructus Momordicae, stevioside, acesulfame, aspartame, sucralose, and composition thereof.

8. the compositions of any one during aforesaid right requires, wherein sweeting agent be selected from erythritol, sucralose, and composition thereof.

9. the compositions of any one during aforesaid right requires, be characterized as compositions also contain be selected from fruit juice, tea, milk solids, and composition thereof one or more beverage ingredients.

10. the compositions of any one during aforesaid right requires, be characterized as also comprise composition weight at least about 75% water.