CN1437487A

CN1437487A - Odor control system comprising a cationic polysaccharide

Info

Publication number: CN1437487A
Application number: CN01808604A
Authority: CN
Inventors: 阿基利·迪辛蒂奥; 安托尼拉·佩斯克; 乔瓦尼·卡卢齐; 亚历山德罗·加格里亚迪诺
Original assignee: Procter and Gamble Ltd
Current assignee: Procter and Gamble Ltd; Procter and Gamble Co
Priority date: 2000-04-25
Filing date: 2001-04-24
Publication date: 2003-08-20
Anticipated expiration: 2021-04-24
Also published as: WO2001080914A1; JP2003530968A; KR20020093067A; MXPA02009947A; BR0110374A; EP1276513B1; JP4738699B2; AR032321A1; EP1149595A1; CA2405606A1; EP1276513A1; CN1247268C; AU2001257204A1; PE20011280A1; KR100585441B1

Abstract

The present invention relates to articles suitable for controlling odors, especially odors associated with bodily fluids, which comprise a cationic polysaccharide, preferably chitosan material, together with an odor controlling agent, preferably an odor absorbent agent and/or a chelating agent. This combination provides synergistic reduced odor control towards malodors associated with bodily fluids like menses.

Description

The odor control system that comprises cationic polysaccharide

Technical field

The present invention relates to be used to control stink, the particularly control and the articles for use such as the absorbent device of the relevant stink of body fluid, these articles for use comprise cationic polysaccharide (preferably deacetylation chitosan material) and stink controlling agent.

Background technology

The stink that exists in environment has multiple source, comprises animate and inanimate.Having a lot of purposes is to avoid this stink to be realized or make minimized product of this stink and articles for use.Specifically, need provide the stink control material of control stink especially, these stinks are produced by human body, or from body fluid such as perspiration, urine, feces, through liquid, vagina effluent etc.

Articles for use such as absorbent article design are for being worn with absorb body fluids such as urine, through liquid and perspiration etc. by people.The example of absorbent device comprises sanitary towel, pantiliner, disposable diaper, incontinence pad, tampon, antiperspirant pad, nursing pad etc.

In use, absorbent device is collected multiple chemical compound such as volatile fatty acid (as isovaleric acid), ammonia, amine (as triethylamine), sulfur-containing compound (as mercaptan, sulfide), alcohol, ketone and aldehyde (as furfural) as you know, and these chemical compounds discharge some offensive odours.These chemical compounds may reside in the body fluid, also can be produced by chemical reaction and/or any degraded by body fluid mechanism when body fluid absorbs in absorbent device such as the women's usefulness protective pad.In addition, body fluid contains microorganism and/or enzyme usually, and these microorganisms and/or enzyme make product produce stink by mechanism of degradation such as corruption degraded, acid degradation, protein degradation, fat acid decomposition etc.The offensive odour that sends from moisture absorption pad makes the wearer feel very awkward in use.

The stink controlling agent of various elimination offensive odours is disclosed in the prior art.In fact, the solution that uses various technical methods such as covering method has been arranged now, that is, covered stink, or absorbed the Already in stink of body fluid and the stink that the degraded back produces with spice.

In the prior art, people concentrate on most of attention on the stink absorption techniques.The example of these type compounds comprises active carbon, clay, zeolite, silicate, starch, cyclodextrin, ion exchange resin and various mixture thereof, and these chemical compounds are described in the following patent: EP-A-348978, EP-A-510619, WO91/12029, WO91/11977, WO89/02698 and/or WO91/12030.Can think that the mechanism of control stink of stink controlling agent of these types is: these reagent physically absorb malodorous compounds and precursor thereof, thereby stop stink to distribute from articles for use such as absorbent device.But these mechanism are not in full force and effect, because can not prevent the formation of stink itself, so can not avoid being realized of stink fully.

So,, still require further improvement stink control to the wide region malodorous compounds although these materials can be controlled the stink relevant with body fluid to a certain extent.

The objective of the invention is provides effective stink control to the wide region stink.More particularly, the purpose of this invention is to provide the articles for use, particularly disposable absorbent article that effective stink control can be provided the wide spectrum stink.

We have found that now:,, cationic polysaccharide and stink controlling agent combined to satisfy above-mentioned requirements as odor control system preferably for disposable absorbent article for articles for use.

We are surprised to find: in the articles for use such as absorbent device that generally contact with body fluid, the stink controlling agent, generally be odor absorbent (as: zeolite and/or cyclodextrin) and/or chelating agen (as: edetate (EDTA)) and cationic polysaccharide, when preferred deacetylation chitosan material is used in combination, aspect stink control, produce cooperative effect.In fact, with absorbent device that body fluid contacts in this combination many to the minimizing of stink during than a kind of (use described stink controlling agent separately or use described cationic polysaccharide separately) of using separately with uniform amt in these two kinds of reagent to the minimizing of stink.

In fact being used in combination of cationic polysaccharide and stink controlling agent combines multiple stink control mechanism in the application's articles for use, makes by these mechanism that total stink amount of being realized is collaborative to be reduced, perhaps even be prevented from.

Do not wish to be fettered by any theory, think cationic polysaccharide, preferred deacetylation chitosan material provides stink to control by the multiple mechanism pair multiple malodor components relevant with body fluid.

At first, owing in polymer architecture, have ionizable Cationic functional groups,, polysaccharide absorbs and retention property so having stink.These functional groups are ammonium normally, and when polymer was drying, most of ammonium wherein was the form of salt, and when contacting with body fluid, these functional groups will dissociate and break (salvation).Under the disassociation state, polymer chain has a series of functional groups that are attached thereto, and these functional groups have identical electric charge (as-NH ₃ ⁺⁺H ₃So they are mutually exclusive N-).This will cause polymer architecture to expand, and make its further stink molecule of absorption band negative charge, thereby to its control.

The second, the positively charged cation group in the polysaccharide can with the electronegative anionic functional group such as the carboxyl in the protein that exist in the body fluid or individuality that has hydroxyl such as short chain acids (as butanoic acid) reaction.This will form three dimensional network (gelatine of body fluid) between the molecule of cationic polysaccharide and these band anionic groups, this gelatine will be held back most of stink molecules (as lipoid and acid) thereby the control stink.

The 3rd and the more important thing is, particularly aminopolysaccharide (deacetylation chitosan material) can be as antimicrobial can to think cationic polysaccharide.In fact, there is the polysaccharide of positively charged cation group can disturb the negative charged surface of microorganism wall, therefore can suppresses these microbial growths, perhaps even kill these microorganisms.These cationic polysaccharides also with the electronegative surface of interferases, make enzyme deactivation with this, and enzymatic activity is the root that forms malodor components as microbial activity.Cationic polysaccharide such as deacetylation chitosan material can also work by its indirect antimicrobial acivity by some micro-nutrients of binding such as lipoid and/or mineral.

Surprisingly, the existence of cationic polysaccharide such as deacetylation chitosan material has improved the efficient of stink controlling agent such as odor absorbent.Do not wish to be fettered, think cationic polysaccharide control enzyme and the microbial growth that is generally deacetylation chitosan material in this application by any theory, thus the amount of the malodorous compounds that enzyme is relevant with microbial activity in control and the body fluid.In other words, cationic polysaccharide reduce or even prevent the formation of malodorous compounds, thereby reduce the total amount of the stink that needs control.This just makes that the stink controlling agent that is generally odor absorbent (as zeolite and/or cyclodextrin) can be with the live vol work that reduces.In fact, this just can be more effectively and continues to use stink controlling agent among the application.In fact, use down separately the stink controlling agent with similarity condition and compare without cationic polysaccharide, the saturation point of the stink controlling agent that is used in combination with cationic polysaccharide of the present invention just can reach after the operating period that prolongs, and generally was that the absorbent device (pantiliner, liner) that contact with body fluid just can reach after the time that wears of prolongation.

Advantageously, think that the stink controlling agent that is generally odor absorbent also reduces stink by the volatility stink help cationic polysaccharide that (space between absorbent device and the apparatus urogenitalis surface) in the stink and headroom that exist in the absorb body fluids exists.Therefore, thus this combination can also not work with the volatility malodor components that polysaccharide directly contacts to from body fluid, distributing.In fact, this combination can be carried out stink control to the malodor components of wide region, if use a kind of in this two classes reagent separately, then can not control fully these malodorous compounds.

Be astoundingly, cationic polysaccharide be deacetylation chitosan material exist above chelating agen the time cause the improvement of its antimicrobial properties.Do not wish to be fettered, think that the chelating agen that uses among the application improves the antimicrobial properties of cationic polysaccharide by its indirect antimicrobial acivity by any theory.In fact, chelating agen can some micro-nutrients of binding such as positively charged somatomedin, is generally Ca ⁺⁺, K ⁺, Mg ⁺⁺Advantageously, the combination of this two classes mechanism causes the collaborative minimizing that stink forms.

In the application's a preferred embodiment, disposable absorbent article has the apertured polymeric film top flat.This top flat helps further to improve stink control benefit.

In another preferred embodiment of the application, disposable absorbent article has the breathability egative film.This helps further to improve stink control benefit.In this application even more preferably, disposable absorbent article has breathability egative film and apertured polymeric film top flat simultaneously.

The present invention preferably relates to disposable absorbent article such as pantiliner, sanitary towel, pad for incontinence, diaper, tampon, interlabial pad, hidroschesis pad, surgical operation with pad, breast pad, human or animal's waste disposal articles for use etc.Other articles for use of Shi Yonging also comprise and are designed to the articles for use that contact with human body such as clothes, binder, heat pad, acne pad, cold pad, compress (compresses), surgical operation usefulness pad/dressing (dressings) etc. in the present invention, the clean body articles for use are as the wiper/thin paper (as: cloudy health wiper in baby's wiper, the women) of dipping, absorb articles for use such as shoe pad, the vest insert etc. of perspiration, be used for the articles for use of animal such as toy etc.

Background technology of the present invention

Disclose among the WO99/61079 by using triglyceride and poly-glycosides product such as disposable diaper and sport pants (training pants), sanitary towel and tampon and natural polymer such as chitosan or alginate and the synthetic polymer of substrate as handling with surfactant with the minimizing stink of the stink absorbent properties of raising compositions.

Disclose among the WO99/32967 when the chitosan and the chitin based polyalcohol that are coated in increased antimicrobial activity on hydrophobic material such as the polypropylene.

In these prior aries, do not have one piece openly to comprise cationic polysaccharide and the additional stink controlling agent of odor absorbent such as zeolite and/or cyclodextrin or the absorbent device of chelating agen such as edetate of being generally that is generally deacetylation chitosan material, say nothing of the collaborative minimizing that this combination causes stink.

Summary of the invention

The present invention relates to be used to control stink, the preferred articles for use of the stink relevant with body fluid, disposable absorbent article preferably, these articles for use comprise cationic polysaccharide and additional stink controlling agent.In the preferred embodiment of the invention, these articles for use also comprise sucting wet gel material.

Detailed Description Of The Invention

" articles for use " are any threedimensional solid materials that expression can comprise cationic polysaccharide and stink controlling agent among the application.Do not prepare to wash or deposit with term " disposable " expression among the application or reuse do articles for use articles for use (that is, promptly prepare to throw away after using once, preferably the mode with environmentally compatible reclaim, compost or processing).Term among the application " absorbent device " uses with its broad sense, comprises any articles for use that can receive and/or absorb and/or hold and/or keep fluid and/or ejection, particularly body fluid and/or ejection.

The preferred articles for use of the present invention be when being designed to wear and wearer's Body contact to receive disposable absorbent article, as pantiliner, sanitary towel, catamenial products, incontinence insert/pad, diaper, tampon, interlabial pad/insert, breast pad, human or animal's waste disposal articles for use etc. from the fluid/ejection of health.This class human urine or feces are handled articles for use and are generally comprised porose and be in the bag of the flange around the hole, preferably it are fixed to wearer's genital area and/or perianal region with binding agent.Any feces known in the art or urine are handled articles for use and all are applicable to the present invention.These articles for use are described in as among the WO99/00084 to WO99/00092.Other is applicable to that articles for use of the present invention also comprise other articles for use of being designed to be close to or placing near health such as clothes, binder, heat pad, acne pad, cold pad, compress, the pad/dressing of surgical operation usefulness etc., the articles for use of absorption perspiration such as shoe pad, vest insert, hidroschesis pad etc., the clean body articles for use are used for the articles for use of animal such as toy etc. as the wiper/thin paper (as: baby's wiper, women in cloudy health wiper) of dipping etc.

" body fluid and/or bodily exudate " is the ejection/fluid of human body or animal body generation when being illustrated in natural or casual condition and scratching as skin down among the application, comprises as perspiration, urine, through liquid, feces, vaginal secretions etc.

Cationic polysaccharide

Articles for use of the present invention comprise as the cationic polysaccharide of necessary component or its mixture.

Be applicable to that cationic polysaccharide of the present invention is owing to have Cationic functional groups and positively charged polysaccharide.Be applicable to that cationic polysaccharide of the present invention comprises natural and semisynthetic cationic polysaccharide.The example of suitable Cationic functional groups comprises primary, secondary, tertiary amine groups or quaternary ammonium group, and these groups should exist with the alkali form.Preferably there is quaternary ammonium group.Be applicable to cationic polysaccharide of the present invention can be the fiber polysaccharide as have excessive contain at least one can with the cellulose of the quarternary ammonium salt compound of the group of polysaccharide hydroxyl reaction.These cationic polysaccharides are described among WO92/19652 and the WO96/17681, introduce these patents herein as a reference.The preferred aminopolysaccharide of the application's camber, promptly chitin sill, deacetylation chitosan material are with its mixture.

" deacetylation chitosan material " represents chitosan, the chitosan of modification, crosslinked chitosan and chitosan salts in this application.

Chitosan is the chitinous partially or completely deacetylated form of natural polysaccharide.In fact, chitosan is the aminopolysaccharide that carries out deacetylated preparation by chitin (poly--β (1,4)-N-acetyl group-D-glycosamine) usually.

Chitin is widespread in nature, for example in the cell wall of fungus and in the duricrust of insecticide and crustacean.Generally containing 10% to about 15% the chitin of having an appointment in the refuse from the ocean food industry of astacus, Lobster and Eriocheir sinensis, is a kind of resource that is easy to obtain therefore.Under native state, chitin generally only is present in the little thin slice or short fiber material, in the shell or tendon as crustacean.In cellulose general not resemble the Cotton Gossypii without dissolving and deposition or renaturation (re-naturing) just can be formed with the source of the molding articles for use of usefulness again.

More particularly, chitin is a kind of mucopolysaccharide, promptly has the poly-n-acetyl base-D-glycosamine of following formula:

Wherein, x represents the degree of polymerization.Although x can not definitely be measured, it is generally acknowledged that x is about 30 to about 50000.

Chitosan is not a chemical individual single, that determine, and its difference of forming with working condition changes.Also it can be defined as fully deacetylated to form the chitin of solubility amine salt.Chitosan is β-(1,4) polysaccharide of D-glycosamine, and its similar is in cellulose, and difference is that the C-2 hydroxyl on the cellulose is replaced by the primary amine groups in the chitosan.A large amount of free aminos makes chitosan become polymerization weak base.The solution of chitosan generally is high viscosity, is similar to natural gum.

Be applicable to that chitosan of the present invention is the chitosan of purer form.The method of producing pure chitosan is known.Use organic acid such as acetic acid with its demineralizationization after generally chitin being clayed into power.Then by removing protein and lipoid, then by making chitin deacetylated as 40% naoh treatment with concentrated base with alkali such as naoh treatment.The chitosan that washes formation with water is until reaching required pH value.

The performance of aminopolysaccharide, especially chitosan is relevant with the performance of its polyelectrolyte and polymer carbohydrate.Therefore, chitosan is insoluble at water, pH in greater than about 6.5 alkaline solution or organic solvent.Chitosan generally is soluble in the weak solution of organic acid such as formic acid, acetic acid, tartaric acid, glycolic, lactic acid and citric acid, can also be dissolved in the diluted mineral acid, but except the sulphuric acid.The needed acid amount of dissolving chitosan generally is similar to and amino stoichiometry.Because the pKa of the amino that exists in the chitosan is 6.0-7.0, so they are in very rare acid or even can be made this biopolymer have cationic property by protonated near under the neutral condition.This cationic property is the basis that deacetylation chitosan material has multiple benefit.More generally be, cationic polysaccharide, as deacetylation chitosan material can be considered to can with electronegative surface such as protein (as, by to the interference of the electronegative wall construction of microorganism and/or enzyme and as antimicrobial and/or by with body fluid as the proteins react that in liquid, exists and as these fluidic gellant) or may be present in as optional component similar absorbent gelling materials in the articles for use of the present invention (as, in the preferred embodiment of the invention, thereby even contain electrolytical solution in the presence of further strengthen the stink control performance of cationic polysaccharide and outstanding absorbent properties be provided) the linear polyelectrolyte that has high charge density of reaction.

The average degree of deacetylation (D.A.) of the deacetylation chitosan material that the present invention preferably uses is greater than 75%, and preferred 80% to about 100%, even more preferably 90%-100%, and most preferably 95% to about 100%.Degree of deacetylation represents to take off the percent of the amido of acetyl.The hydrogen bond that exists in this feature and this biopolymer is directly related, and influences its structure, dissolubility and final its reactivity.Can use titrimetry, dye adsorption method, UV-VIS, IR and NMR spectrographic determination degree of deacetylation.

Degree of deacetylation can influence the cationic properties of chitosan.The cationic properties of deacetylation chitosan material be can improve by increasing degree of deacetylation, thereby its antimicrobial properties, absorbent properties and gelling property improved.

Be applicable to that deacetylation chitosan material of the present invention comprises water solublity and water-insoluble chitosan.In this application, when a kind of material in excessive water basically dissolving form the solution of transparent and stable, thereby lose its initial grain shape, in whole aqueous solution, become basically when disperseing with molecular forms, it is water miscible that this material will be considered to.The present invention especially preferably uses the water-soluble chitosan material, that is, and and dissolving at least 0.5 gram, preferably at least 1 gram, more preferably at least 2 gram deacetylation chitosan materials in 100 gram water of an atmospheric pressure and 25 ℃." dissolubility " of given chemical compound should be interpreted as the amount of dissolved this chemical compound in the deionized water of an atmospheric pressure and 25 ℃ in this application, not have precipitate to exist in the water.

As general rule, the water-soluble chitosan material does not have the big degree of cross linking, and is water-insoluble because crosslinked meeting becomes deacetylation chitosan material.

The water-soluble chitosan material that defines among the application has at the stink controlling party mask that great majority is existed and be dissolved in the malodorous compounds in the body fluid bigger active benefit is arranged.In fact, these water-soluble chitosan materials can absorb and/or static interference water solublity malodor components such as short chain acids (as butanoic acid) or low-molecular-weight alcohol (as ethanol).

Deacetylation chitosan material (that is: the chitosan of chitosan and chitosan salts, modification and crosslinked chitosan) generally can have the molecular weight of wide region.Deacetylation chitosan material with wide range of molecular weights is applicable to the present invention, and the molecular weight that is used for deacetylation chitosan material of the present invention is generally 1000-10000000 gram/gram mole, more preferably 2000-1000000.Molecular weight is meant weight average molecular weight.The method of measuring weight average molecular weight of chitosan materials is known to those skilled in the art.General method comprises as light scattering, intrinsic viscosity and gel permeation chromatography.Generally represent its molecular weight most convenient with the viscosity of deacetylation chitosan material in 25 ℃ 1.0wt% aqueous solution with the Brookfield viscometer determining.General viscosity by coming the indirect determination deacetylation chitosan material with the viscosity of measuring corresponding chitosan salts as the acetic acid aqueous solution of 1.0wt%.Be applicable to that the viscosity of deacetylation chitosan material of the present invention in 25 ℃ 1.0wt% aqueous solution is preferably about 1mPa.s (1 centipoise) to about 80000mPa.s (80000 centipoise), more preferably from about 30mPa.s (30 centipoise) is to about 10000mPa.s (10000 centipoise), even more preferably 50mPa.s (50 centipoise) is to about 1000mPa.s (1000 centipoise), and most preferably 100mPa.s (100 centipoise) is to about 500mPa.s (500 centipoise).

The pH of deacetylation chitosan material depends on the preparation method of deacetylation chitosan material.The deacetylation chitosan material that the present invention preferably uses has acid pH, generally is 4-6, more preferably 4-5.5, even more preferably 4.5-5.5.Highly preferred pH is about pH5, and this is corresponding to the pH of skin.The pH of 1% the chitosan soln (1 gram deacetylation chitosan material is dissolved in the 100 gram distilled water) that " pH of deacetylation chitosan material " among the application expression is measured with pH meter.

Thereby the cationic properties of deacetylation chitosan material and its antimicrobial properties, absorbent properties and gelling property will increase with the increase of its acid performance.But acidity is too high harmful to skin safety.Therefore, the highly preferred pH of the present invention is the deacetylation chitosan material of 4.5-5.5, this just on the one hand stink control and fluid handling properties and skin-friendliness on the other hand between reached best balance.

Be specially adapted to aminopolysaccharide of the present invention and comprise aminopolysaccharide salts, especially chitosan salts.Can form aminopolysaccharide salts such as chitosan salts with multiple acid.Be suitable for sour water-soluble or be partially soluble in water has enough acidity to be unlikely to the acid hydrolysis that causes aminopolysaccharide too greatly again with the ammonium salt that forms aminopolysaccharide, and the amount of its existence should be enough to the avtive spot of protonated aminopolysaccharide.

Preferred acid can be represented with following formula:

R-(COOH) _n

Wherein, n is 1 or 2 or 3, and R represents that perhaps R is a hydroxyl simply by at least a one or the divalent organic group that constitutes in carbon, hydrogen and optional oxygen, nitrogen and the sulfur.Preferred acid is the monobasic that is made of carbon, hydrogen, oxygen and nitrogen and dicarboxylic acids (below be also referred to as aminoacid).These acid are highly desirable in the present invention; because when they are close to or are close to the human body use; they are biological acceptable; except that above-mentioned acid, exemplary acid comprises citric acid; formic acid; acetic acid; acetylaminoacetic acid; aspirin; fumaric acid; glycolic; iminodiacetic acid; the itaconic acid; lactic acid; maleic acid; malic acid; nicotinic acid; 2-Pyrrolidone-5-carboxylic acid; salicylic acid; succinamic acid; succinic acid; ascorbic acid; aspartic acid; glutamic acid; 1,3-propanedicarboxylic acid; malonic acid; acetone acid; the sulfonyl oxalic acid; benzoic acid; Epoxysuccinic acid; adipic acid; thiodiglycolic acid and thioglycolic acid.Any chitosan salts that any reaction in aminopolysaccharide and these acid forms all is applicable to the present invention.

The example of the chitosan salts that forms with mineral acid comprises but is not defined as chitosan salts hydrochlorate, chitosan hydrobromate, chitosan phosphate, chitosan sulfonate, chitosan chlorosulfonate, chitosan chloracetate and composition thereof.The example of the chitosan salts that forms with organic acid comprises but is not defined as the chitosan formates, the chitosan acetate, the chitosan lactate, the chitosan glycollate, the chitosan malonate, chitosan epoxy succinic hydrochlorate, the chitosan benzoate, the chitosan adipate, the chitosan citrate, the chitosan Salicylate, the chitosan propionate, chitosan nitrilotriacetic acid(NTA) salt, the chitosan itaconate, the chitosan hydroxyl acetate, the chitosan butyrate, the chitosan isobutyrate, chitosan acrylates and composition thereof.Also can be with comprising that the mixture as mineral acid and organic acid acid prepares chitosan salts.

Aminopolysaccharide salts, the especially chitosan salts that the present invention highly preferably uses is those aminopolysaccharide salts that aminopolysaccharide and aminoacid reaction form.Aminoacid is the molecule that had not only contained acidic group but also contained amido functional group.The amino acid salts that highly preferably uses aminoacid and be those aminopolysaccharides without other sour reason has higher skin-friendliness.In fact, natural to be present on the skin therefore be non-irritating to most of aminoacid.2-pyrrolidone-5-carboxylic acid's chitosan salts is effective humidizer and skin is not had zest.Under the situation that the accidental misuse of hanging down back wet and/or articles for use takes place, this class deacetylation chitosan material is suitable.

The aminoacid that the present invention uses comprises linearity and/or cyclic amino acid.Be applicable to that amino acid whose example of the present invention comprises but is not defined as alanine, valine, leucine, isoleucine, proline, phenylalanine, triptofane, methionine (metionine), glycine, serine, cysteine, tyrosine, agedoite, glutamine, aspartic acid, glutamic acid, lysine, arginine, istydine, hydroxyproline etc.The specially suitable example of cyclic amino acid is the 2-pyrrolidone-5-carboxylic acid, and this is a kind of carboxylic acid of the pyrrolidin-2-one that is shown below:

Highly preferred chitosan salts is the pyrrolidone carboxylic acid salt (this is the chitosan salts of 2-Pyrrolidone-5-carboxylic acid) of the pyroglutamate (this is the mixture of chitosan (macromole) and pyroglutamic acid (independent monomer)) and the chitosan of chitosan.

With reference to WO98/07618, this patent has described the preparation method of this aminopolysaccharide salts in detail.

Be applicable to that other deacetylation chitosan material of the present invention comprises the crosslinked aminopolysaccharide and the aminopolysaccharide of modification, the especially crosslinked chitosan and the chitosan of modification.

Be applicable to that cross-linking agent of the present invention is the organic compound that has two functional groups that can react with the active group on the aminopolysaccharide that is generally deacetylation chitosan material at least.The example of this active group comprise but be not defined as carboxylic acid (COOH) or hydroxyl (OH).The example of suitable crosslinking agent comprises but is not defined as diamidogen, polyamine, glycol, polyhydric alcohol, dicarboxylic acids, polybasic carboxylic acid, polyoxide etc.A kind of method of introducing cross-linking agent in chitosan soln is in the process of preparation solution cross-linking agent and chitosan to be mixed.Another kind of suitable crosslinking agent comprises the metal ion that has two above positive charges, as Ca ²⁺, Al ³⁺, Fe ³⁺, Ce ³⁺, Ce ⁴⁺, Ti ⁴⁺, Zr ⁴⁺And Cr ³⁺Because the cation on the chitosan has antimicrobial properties, therefore preferably do not use can with the cross-linking agent of cationoid reaction, unless there is not alternative cross-linking agent.

In the embodiment of using cross-linking agent, appropriate amount based on the cross-linking agent of total dry weight of the crosslinked employed chitosan of chitosan of preparation is more preferably 0.05-10wt%, most preferably 0.1-5wt% of the preferred 0.02-20wt% of 0.001-30wt%.

The chitosan that is applicable to modification of the present invention is any chitosan and the chitin that wherein has side group on the dextran chain.The example of the chitosan of this modification comprises carboxymethyl chitosan, methyl pyrrolidone chitosan, ethylene glycol chitosan etc.For example, describe the methyl pyrrolidone chitosan among the US5378472, introduced this patent herein as a reference.For example, describe water-soluble glycol chitosan and carboxymethyl chitosan among the WO87/07618, introduced this document herein as a reference.

The chitosan that is specially adapted to modification of the present invention comprises chitosan derivative or the bonded chitosan derivative of ionic bond that makes chitosan salts contact the water solublity covalent bonds that obtains with the electrophilic organic reagent.These water-soluble chitosan derivants are described among the EP-A-737692, introduce this document herein as a reference.

Be applicable in each molecule of electrophilic organic reagent of preparation chitosan derivative and contain 2-18 carbon atom or more a plurality of carbon atom, generally contain 2-10 carbon atom.In addition, the electrophilic organic reagent also contains the active group that can form covalent bond with nucleopilic reagent.General electrophilic organic reagent comprises as oxirane, expoxy propane, epoxy butane, (+)-2,3-Epoxy-1-propanol, 3-chloro-1, the 2-propylene glycol, chloromethane, chloric ethane, isatoic anhydride, succinic anhydrides, octenyl succinic acid anhydride, acetic anhydride, gamma-butyrolacton, the b-propiolactone, 1, the 3-N-morpholinopropanesulfonic acid lactone, acrylamide, the glycidyl trimethyl ammonium chloride, glycidyl dimethyl alkyl ammomium chloride such as glycidyl dimethyl lauryl chlorination ammonium, chlorosulfonic acid sodium, Dimethylsulfate, the ethyl chloride sodium sulfonate, chloroacetic acid, the alkyl phenyl glycidyl ether, glycidyl trimethoxysilane, 1,2-epoxy dodecane.The preferred electrophilic organic reagent of one class comprises to be had epoxy radicals and at least one acidic group (preferably diacyloxy) and has 3-18 carbon atom, preferred those electrophilic organic reagents of 3-6 carbon atom in each molecule.Other preferred electrophilic organic reagent comprises cis electrophilic organic reagent and trans electrophilic organic reagent, preferred especially cis electrophilic organic reagent.The electrophilic organic reagent can with unhindered amina or the not deutero-hydroxyl reaction in the chitosan.As you know: it is generally acknowledged that the amine functional group in the chitosan is the nucleophilic position stronger than hydroxyl.So more weak electrophilic reagent than with chitosan in the easier and chitosan of hydroxyl in the amido reaction.

In order to reach the desired properties of chitosan derivative, i.e. its water miscible performance preferably is substituted with the electrophilic organic reagent of effective dose on chitosan.The MS that is applicable to chitosan derivative of the present invention (chitosan of modification) is generally 0.03-10 mole electrophilic organic reagent in every mole of glycosamine monomeric unit.The molal quantity of the electrophilic organic reagent that on chitosan, replaces in every mole of glycosamine monomeric unit of term mole replacement amount (MS) expression.

Can also prepare the chitosan that also contains other substituent modification except that containing electrophilic organic reagent group in addition, other substituent example has hydroxyalkyl ether (as ethoxy or hydroxypropyl ether), carboxyalkyl ether (as carboxymethyl), amide groups (as succinyl group), ester group (as acetate groups) or amino (as 3-(trimethyl ammonium chloride)-2-hydroxypropyl or 3-(dimethyl stearyl ammonium chloride)-2-hydroxypropyl ether)).These other substituent groups can be introduced before or after the reaction of chitosan salts and electrophilic organic reagent, also can introduce in chitosan salts and electrophilic organic reagent and the reaction of other derivative reagent.

Generally can obtain the chitosan derivative of covalent bonds with the method that comprises the steps: (a) chitosan salts (as: in the above-mentioned chitosan salts any) is dispersed in the alkaline aqueous medium of effective dose, formation contains the neutral chitosan of free amino, (b) in serosity, introduce the electrophilic organic reagent, (c) make serosity keep certain temperature and regular hour, to promote the replacement of electrophilic organic reagent on chitosan effectively, form the chitosan derivative of covalent bonds, and the chitosan of covalent bonds is dissolved in the water-bearing media.It is the form that the bonded form of ionic bond also can be made covalent bonds that chitosan derivative can be made salifiable form.The method for preparing these chitosan derivatives has been described in detail in detail among the EP-A-737692, has introduced this document herein as a reference.

Suitable chitosan can be purchased from a plurality of producers.The example of the deacetylation chitosan material that is purchased has those chitosans that are purchased from Vanson Company.The chitosan salts that the present invention preferably uses is Kytamer PC Chitosan PCA (being also referred to as 2-pyrrolidone-5-carboxylic acid's chitosan salts); its degree of deacetylation is greater than 85%; dissolubility in the water is 1% (under 1 atmospheric pressure and 25 ℃ in the distilled water of 100 grams dissolving 1 gram); pH is 4.5, and viscosity is 100-300cps.Kytamer PC Chitosan PCA can be purchased from Amerchol Corporation, and trade mark is Kytamer  PC.

The cationic polysaccharide that generally contains in the articles for use such as disposable absorbent article or the amount of its mixture are 0.5gm ^-2-500gm ^-2, preferred 1-200gm ^-2, more preferably 3gm ^-2-100gm ^-2, 4gm most preferably ^-2-50gm ^-2

The stink controlling agent

Can also comprise in the articles for use of the present invention and be in above-mentioned cationic polysaccharide or its at least a additional stink controlling agent or its mixture above mixture.

The stink controlling agent that comprises in articles for use of the present invention such as the disposable absorbent article or the amount of its mixture are generally 1gm ^-2-600gm ^-2, preferred 5gm ^-2-400gm ^-2, 10gm most preferably ^-2-200gm ^-2

Be applicable to that stink controlling agent of the present invention comprises odor absorbent known to a person of ordinary skill in the art, i.e. active carbon, clay, zeolite, kieselguhr, starch, cyclodextrin, ion exchange resin etc.Preferred zeolite of the present invention and/or cyclodextrin.Other is applicable to that stink controlling agent of the present invention comprises chelating agen or its mixture.The mixture that can also contain odor absorbent and chelating agen in the articles for use of the present invention.

The present invention is based on following discovery: cationic polysaccharide (particularly deacetylation chitosan material) and stink controlling agent (preferred odor absorbent (preferred zeolite and/or cyclodextrin)) and/or chelating agen (preferred edetate) have to and body fluid, particularly the stink that closes through liquid phase work in coordination with the benefit that stink is controlled.

Think cationic polysaccharide of the present invention generally be by reduce or even stop microorganism and the growth of enzyme in body fluid to prevent the formation of malodorous compounds, thereby reduce the total amount of the malodorous compounds relevant with body fluid.This just can make odor absorbent more effectively use between the extended period before these reagent absorbing activity centers reach capacity.Advantageously, these stink controlling agents are undertaken by following mechanism the stink control of body fluid/ejection as zeolite or cyclodextrin or derivatives thereof: the malodor components that exists in the body fluid that contacts with it in absorbent device not only absorbing, and absorb the volatility malodor components that exists in the absorbent device headroom, if in absorbent device, use cationic polysaccharide as unique stink controlling agent then can not control separately to these malodor components.

In a preferred embodiment of the invention, the percentage ratio that cationic polysaccharide and odor absorbent exist is that the ratio of cationic polysaccharide and odor absorbent is 1: 10-10: 1, preferred 1: 5-5: 1, and more preferably from about 1: 1.In fact, in these ratio ranges, just can obtain best stink control performance to body fluid.

Zeolite

Being specially adapted to odor absorbent of the present invention is zeolite.The application of zeolitic material and production are being known in the art, and in the following document it are described to some extent: ZEOLITE SYNTHESIS, and ACSSymposium Series 398 is edited by M.L.Occelli and H.E.Robson, (1989) 2-7 page or leaf; ZEOLITE MOLECULAR SIEVES, Structure, Chemistry and Use, author D.W.Breck, John Wiley and Sons (1974) 245-250,313-314 and 348-352 page or leaf; MODERNAPPLICATIONS OF MOLECULAR SIEVE ZEOLITES, Ph.D.Dissertation of S.M.Kuznicki, U.of Utah (1980), can be from University of Microfilms International, AnnArbor, Michigan, the 2-8 page or leaf obtains.

Zeolite is the crystal type aluminosilicate of IA family and IIA family element such as Na, K, Mg and Ca, and its chemical composition is generally represented with following empirical formula:

M _2/nO.Al ₂O ₃.ySiO ₂.wH ₂O

Wherein, y is more than or equal to 2, and n is the cation price, and w is the water content in the zeolite cavities (voids).

On structure, zeolite is based on by sharing oxonium ion the AlO of binding mutually ₄And SiO ₄The crystal type inorganic polymer of the complexity of tetrahedral unlimited extension skeleton.This framing structure contains passage or the interconnective hole that is occupied by cation and hydrone.

The structural formula of zeolite is based on crystal unit cell, and minimum construction unit is expressed as:

M _x/n[(AlO ₂) _x(SiO ₂) _y].wH ₂O

Wherein, n is the price of cation M, and w is the water molecule number in each unit structure cell, and x and y are the tetrahedral sums in each unit structure cell, and the value of y/x is generally 1-5.

Zeolite can be natural, also can be synthetic.The present invention preferably uses synthetic zeolite.Be applicable to that zeolite of the present invention comprises zeolite A, zeolite P, zeolite Y, X zeolite, zeolite DAY, zeolite ZSM-5 or its mixture.Zeolite A most preferably.

According to the present invention, zeolite is preferably hydrophobic.This generally can be by increasing SiO ₂And AlO ₂Mole recently realize, make x/y be at least 1, preferred 1-500, most preferably 1-6.

Generally containing the zeolite of 100% purity or the amount of its mixture in the articles for use of the present invention is 0gm ^-2-300gm ^-2, more preferably 40gm ^-2-250gm ^-2, 60gm most preferably ^-2-200gm ^-2

Cyclodextrin and derivant thereof

Being specially adapted to odor absorbent of the present invention is cyclodextrin or derivatives thereof or its mixture.The reason of preferred these materials is that cationic polysaccharide generally is a part water solublity or non-water-soluble because they have the dual-use function of dissolving cationic polysaccharide among the present invention, and they itself have the ability that absorbs stink.

Therefore, the cyclodextrin or derivatives thereof can be used as the carrier of the cationic polysaccharide that is generally deacetylation chitosan material, thereby help to make deacetylation chitosan material, particularly the deacetylation chitosan material of part water solublity or water-insoluble (that is, it is generally less than 0.5 gram at 1 atmospheric pressure with 25 ℃ the dissolubility of 100 grams in the distilled water) contacts more nearly with water solublity malodor components such as amine, the butanoic acid etc. of body fluid and lipoid, protein and/or sugar degraded generation.Think: the cyclodextrin or derivatives thereof helps further to dissolve cationic polysaccharide, and this causes obviously improved total stink control ability (cooperative effect).

The unique shape in hole and physical and chemical performance make cyclodextrin molecular can absorb organic molecule or part organic molecule (forming inclusion complex with it), and these molecules can be inserted in the hole.

Term among the application " cyclodextrin " comprises unsaturated cyclodextrin, particularly alpha-cyclodextrin, beta-schardinger dextrin-, gamma-cyclodextrin and/or its derivant of any known cyclodextrin as containing 6-12 glucose unit, and/or its mixture.Alpha-cyclodextrin is made up of 6 glucose units, and beta-schardinger dextrin-is made up of 7 glucose units, and gamma-cyclodextrin is made up of 8 glucose units, and these glucose units are arranged lopping cheese ring.The specific coupling of glucose unit and configuration make gives the hollow rigidity taper molecular structure that dextrin has designated volume." lining " of inner cavity formed by hydrogen atom and glucosides bridging oxygen atom; Therefore, its surface is hydrophobic relatively.Can use non-deriving (just) beta-schardinger dextrin-among the present invention.

The cyclodextrin that the present invention especially preferably uses is cyclodextrin such as alpha-cyclodextrin and derivant, gamma-cyclodextrin and derivant thereof, deutero-beta-schardinger dextrin-and/or its mixture of high water soluble.

Cyclodextrin derivative is mainly converted to the molecular composition of OR group by some OH groups wherein.Cyclodextrin derivative comprises that R wherein is methyl or ethyl as those cyclodextrin derivative with short-chain alkyl such as methylated cyclodextrin and ethylating cyclodextrin; Have the substituent cyclodextrin derivative of hydroxyalkyl such as hydroxypropyl cyclodextrin and/or hydroxyethyl cyclodextrin, R wherein is-CH ₂-CH (OH)-CH ₃Or-CH ₂CH ₂-OH group; The cyclodextrin of branched cyclodextrin such as maltose binding; The cation cyclodextrin is as containing the cyclodextrin of 2-hydroxyl-3-(dimethylamino) propyl ether, and R wherein is-CH ₂-CH (OH)-CH ₂-N (CH ₃) ₂, this group is a cation under low pH; Quaternary ammonium, as 2-hydroxyl-3-(trimethyl amino) propyl ether chloride ion, R wherein is-CH ₂-CH (OH)-CH ₂-N ⁺(CH ₃) ₃Cl ^-Anion cyclodextrin such as carboxymethyl cyclodextrin, cyclodextrin sulfate and cyclodextrin succinyl hydrochlorate; Both sexes cyclodextrin such as carboxymethyl/Quaternised ammonium cyclodextrin, wherein at least one glucopyranose unit has the cyclodextrin of 3-6-dehydration ring maltose structure, as list-3-6-cyclodextrin that dewaters, this material is disclosed in " Optimal Performanceswith Minimal Chemical Modification of Cyclodextrins ", F.Diedaini-Pilard and B.Perly, The 7 ^ThInternational Cyclodextrin Symposium Abstracts in the 49th page of April in 1994, introduces the document herein as a reference; And composition thereof.Other cyclodextrin derivative is disclosed in the following patent: 1969.2.4 is issued to people's such as Parmerter United States Patent (USP) 3426011; 1969.7.1 be issued to people's such as Parmerter United States Patent (USP) 3453257,3453258,3453259 and 3453260; 1969.8.5 be issued to people's such as Gramera United States Patent (USP) 3459731; 1971.1.5 be issued to people's such as Parmerter United States Patent (USP) 3553191; 1971.2.23 be issued to people's such as Parmerter United States Patent (USP) 3565887; 1985.8.13 be issued to people's such as Szejtli United States Patent (USP) 4535152; 1986.10.7 be issued to people's such as Hirai United States Patent (USP) 4616008; 1987.7.7 be issued to people's such as Ogino United States Patent (USP) 4678598; 1987.1.20 be issued to people's such as Brandt United States Patent (USP) 4638058; 1988.5.24 be issued to people's such as Tsuchiyama United States Patent (USP) 4746734; Introducing these patent documentations herein all is as a reference.

The high water soluble cyclodextrin is that at room temperature the water solubility in the 100ml water is at least about 10g, preferably is at least about 20g, more preferably is at least about those cyclodextrin of 25g.These cyclodextrin are easy to use, but generally expensive than non-deutero-beta-schardinger dextrin-.The example that is applicable to preferred water soluble cyclodextrin derivant of the present invention is the hydroxypropyl alpha-cyclodextrin, the alpha-cyclodextrin that methylates, the beta-schardinger dextrin-that methylates, ethoxy beta-schardinger dextrin-and hydroxypropyl.The substitution value of hydroxyalkyl cyclodextrin derivant is preferably about 1 to about 14, more preferably about 1.5 to about 7, and wherein, the total number of OR group is defined as substitution value in each cyclodextrin.The substitution value of methylated cyclodextrin derivant is generally about 1 to about 18, is preferably about 3 to about 16.A kind of known beta-schardinger dextrin-that methylates is to be known as seven-2 of DIMEB usually, 6-two-O-methyl beta-schardinger dextrin-, and wherein, each glucose unit has 2 methyl approximately, and its substitution value is about 14.A kind of preferred, the easier beta-schardinger dextrin-that methylates that is purchased is the random beta-schardinger dextrin-that methylates, and its substitution value is about 12.6.Preferred cyclodextrin is from as Cerestar USA, Inc. and Wacker Chemicals (USA), the cyclodextrin that Inc. is purchased.

It is ideal using the mixture of cyclodextrin.These mixture can with the stink molecular complex with wideer molecular size of wide region.At least a portion of this mixture is alpha-cyclodextrin or derivatives thereof, gamma-cyclodextrin or derivatives thereof and/or beta-schardinger dextrin-or derivatives thereof preferably.

The amount that generally contains cyclodextrin or derivatives thereof or its mixture in the articles for use of the present invention is 0gm ^-2-300gm ^-2, more preferably 5gm ^-2-250gm ^-2, 7gm most preferably ^-2-200gm ^-2

Chelating agen

Be applicable to that chelating agen of the present invention is those chelating agen known to a person of ordinary skill in the art.Suitable chelating agen comprises aromatic chelator, aminocarboxylate chelating agen, other chelating agen such as the ethylenediamine N that replaces as phosphine acid salt chelator, polyfunctional group, N '-disuccinic acid, aspartic acid, glutamic acid, malonic acid, glycine and composition thereof.

Be applicable to that phosphine acid salt chelator of the present invention comprises ethydronic acid, alkali metal ethane 1-hydroxyl diphosphate and aminophosphonic acid salt compound, the aminophosphonic acid salt compound comprises that amino alkylidenyl gathers (alkylene phosphonic acids salt), alkali metal ethane 1-hydroxyl diphosphate, nitrilo-trimethylene phosphonic salt, ethylenediamine tetramethylene phosphonic acid salt, amino three (methylene phosphonic acid salt) (ATMP) and diethylenetriamine pentamethylenophosphonic acid salt.These phosphonate compounds can exist with its sour form, also can with its acid functional group partly or entirely on have different cationic salt forms and exist.In general, these amino phosphonates do do not contain the alkyl or alkenyl that surpasses 6 carbon atoms.The phosphine acid salt chelator that the present invention preferably uses is diethylenetriamine pentamethylenophosphonic acid salt (DETPMP).These phosphine acid salt chelators can be purchased from Monsanto, and trade mark is DEQUEST .

The aromatic chelating agent that also can use polyfunctional group to replace in the compositions of the present invention.Be issued to people's such as Connor United States Patent (USP) 3812044 referring to 1974.5.21.The chemical compound of preferred this class acid form be the dihydroxy disulfobenzene as 1,2-dihydroxy-3,5-disulfobenzene.

The biodegradable cheating agent that the present invention preferably uses is ethylenediamine N, N '-disuccinic acid or its alkali metal or alkaline-earth metal, ammonium or substituted ammonium salt or its mixture.1987.11.3 be issued in the United States Patent (USP) 4704233 of Hartman and Perkins and ethylenediamine N be described in detail in detail, N '-disuccinic acid, particularly its [S, S] isomer.Ethylenediamine N, N '-disuccinic acid can be from being purchased as Palmer Research Laboratories, and commodity are called ssEDDS .

Be applicable to that aminocarboxylate chelating agen of the present invention comprises edetate (EDTA), diethylentriamine pentacetate (DTPA), N-hydroxyethyl-ethylenediamine triacetate, nitrilotriacetic acid(NTA) salt, ethylenediamine tetrapropionic acid salt, triethylenetetraaminehexaacetic acid salt, diethylentriamine pentacetate, ethanol Diglycocol, trimethylen-edinitrilo-tetraacetic acid (PDTA) and methylglycine oxalic acid (MGDA), they can be sour forms, also can be its alkali metal, ammonium or the salt form that replaces ammonium.Being specially adapted to aminocarboxylate of the present invention is edetate (EDTA), diethylentriamine pentacetate (DTPA) or its mixture.

The chelating agen that the present invention more preferably uses be selected from edetate ,-triacetate ,-diacetin and-one acetate; Ethylenediamine N, N '-disuccinic acid (sodium salt), ethylenediamine five (methylene phosphonic acid) (sodium salt), ethylenediamine tetraacetic (methylene phosphonic acid) or its mixture.Most preferred chelating agen is an edetate.

The amount that generally contains chelating agen or its mixture in the articles for use of the present invention is 0gm ^-2-300gm ^-2, more preferably 5gm ^-2-250gm ^-2, 7gm most preferably ^-2-200gm ^-2

Think: chelating agen of the present invention has participated in the antimicrobial acivity of cationic polysaccharide of the present invention.In fact, their chelatings the positively charged nutrient such as the somatomedin (as: calcium, magnesium and/or potassium) of microorganism, these somatomedin are all very crucial for the cultivation of any microorganism, thereby weakened this cultivation.The antimicrobial direct activity that therefore they replenished cationic polysaccharide of the present invention, particularly deacetylation chitosan material.Even also be like this in the preferred embodiment of the invention, in this embodiment, use the deacetylation chitosan material of high deacetylized (greater than 75%) with the present invention's definition, these deacetylation chitosan materials thereby can not be as at positively charged nutraceutical chelating agen.

In the preferred embodiment of the invention, the percentage by weight that cationic polysaccharide and chelating agen exist is that the ratio of cationic polysaccharide and chelating agen is 1: 10-10: 1, preferred 1: 5-5: 1, more preferably 1: 3-3: 1.In fact, in these ratio ranges, just can obtain best stink control performance to body fluid.

Optional reagent

Articles for use of the present invention can also comprise other conventional reagents such as sucting wet gel material.

Sucting wet gel material

Can know from production practices in recent years: sucting wet gel material (being sometimes referred to as " superabsorbent agent ") just is widely used in the absorbent device.Sucting wet gel material is to have the material that absorbs and keep fluid and the dual performance of stink, therefore can further improve benefit of the present invention.

The sucting wet gel material that the present invention especially preferably uses is an absorbent gelling materials, that is, mainly be electronegative sucting wet gel material.These sucting wet gel materials can be any materials with superabsorbent performance, and functional group wherein is an anion, i.e. sulfonate radical, sulfate radical, phosphate radical or carboxyl.Preferred functional group is a carboxyl.The absorbent gelling materials that the present invention especially preferably uses is synthetic absorbent gelling materials.The preferred synthetic absorbent gelling materials of the present invention is because in being used in identical absorbent device the time, compare them with the absorbent properties of natural absorbent gelling materials such as anion polysaccharide and have higher stink and absorption of fluids performance, even also be like this under pressure.

These functional groups generally are connected on the slight crosslinked acrylic acid basis polymer.For example, this base polymer can be polyacrylamide, polyvinyl alcohol, ethenyl maleic anhydride copolymer, polyvinylether, polyvinyl sulfonic acid, polyacrylic acid, polyvinylpyrrolidone and polyethylene morpholine.Also can use these monomeric copolymers.Specific base polymer comprises acryionitrile grafted starch, starch polyacrylate and the isobutene. copolymer-maleic anhydride of crosslinked polyacrylate, hydrolysis.

These materials contact water (as, contact with urine, blood etc.) time form hydrogel.The sucting wet gel material of the highly preferred formation hydrogel of one class is based on particularly polyacrylic acid of polyacid.The polymeric material that this class forms hydrogel is these fluids can be sucked those materials that also form hydrogel thus when contact as water or body fluid with fluid (being liquid).These preferred sucting wet gel materials generally comprise water-fast basically, the slight polymeric material crosslinked, the neutral formation hydrogel of part with polymerisable unsaturated acidiferous monomer preparation.In these materials, the polymeric component that is formed by unsaturated acidiferous monomer can comprise whole gellant, also can be grafted on the polymer moieties such as starch or cellulose of other kind.Acrylic acid-grafted starch material is exactly back one type.Therefore, preferred sucting wet gel material comprises the acryionitrile grafted starch of hydrolysis, acrylic acid-grafted starch, polyacrylate, maleic anhydride base co-polymer and combination thereof.Particularly preferred absorbent gelling materials is polyacrylate and acrylic acid-grafted starch.

Regardless of the character of polymers compositions in the preferred sucting wet gel material, these materials generally all are slight crosslinked.Crosslinked that these hygroscopic materials that preferably form hydrogel are become is water-insoluble basically, and the decision of crosslinked also part is by the gel volume of its hydrogel that forms and the polymer performance that can extract.Suitable crosslinking agent is being known in the art, comprise as: (1) has the chemical compound of at least two polymerisable double bonds; (2) have at least one polymerisable double bonds and at least one chemical compound with the functional group of acidiferous monomer material reaction; (3) has the chemical compound of the functional group of at least two and acidiferous monomer material reaction; (4) can form the polyvalent metal compounds of ionic cross-linked bond.The cross-linking agent of mentioned kind is described in detail in the United States Patent (USP) 4076663 that 1978.2.28 is issued to people such as Masuda.Preferred cross-linking agents is two or polyester, the bisacrylamide and two or triallylamine of unsaturated monobasic or polybasic carboxylic acid and polyhydric alcohol.Particularly preferred cross-linking agent is N, N '-methylene-bisacrylamide, trimethylolpropane triacrylate and triallylamine.Cross-linking agent generally constitutes about 0.001mol%-5mol% of preferred material, and more preferably, cross-linking agent constitutes about 0.01mol%-3mol% of the gel rubber material that uses among the present invention.

The sucting wet gel material that the present invention preferably uses is those sucting wet gel materials that the fluid that runs into had higher inlet capacity in absorbent device; This capacity can be with reference to " gel volume " quantificational expression of described sucting wet gel material.Gel volume defines with the amount of the synthetic urine solution that any given absorbent gelling agent buffer (buffer) absorbs, and represents with the gram number/gram gellant of synthetic urine solution.

By the gel volume in the suspension mensuration synthetic urine solution (referring to following people's such as Brandt patent) that forms the dry sucting wet gel material of testing with about 20 parts of synthetic urine solutions of about 0.1-0.2 part.This suspension is kept at ambient temperature, and stir about made it reach swelling equilibrium in 1 hour gently.Calculate gel volume (the gram number/gram sucting wet gel material of synthetic urine solution) with the ratio of the weight portion of gellant in the suspension and liquid volume of from formed hydrogel, removing and suspension cumulative volume then.The gel volume of the sucting wet gel material that the present invention preferably uses is about 20-70 gram synthetic urine solution/gram sucting wet gel material, more preferably 30-60 gram synthetic urine solution/gram sucting wet gel material.

Another feature of most preferred sucting wet gel material is the amount of the polymeric material that extracts that exists in the described material.Can measure the amount of the polymer that can extract with following method: preferred sucting wet gel material sample is contacted with synthetic urine solution reach the needed time period of extraction equilibrium (as, at least 16 hours), from supernatant, filter formed hydrogel then, measure the content of polymer in the filtrate at last.1987.3.31 the Brandt, the Goldman that authorize and the United States Patent (USP) 4654039 of Inglin, authorizing is to disclose the concrete grammar of content that the polymer that extracts of the preferred moisture absorption gellant of the present invention buffer is measured in concrete being used in 32649 again.Be specially adapted to sucting wet gel material in the absorbent device of the present invention and be its balance in synthetic urine solution and can extract content and be no more than the about 17% of sucting wet gel material weight, preferably be no more than about 10%.

The sucting wet gel material of preferred slightly crosslinked formation hydrogel generally uses with the neutral form of its part.In order to reach purpose of the present invention, as the monomeric 25mol% at least that is used to form polymer, preferably 50mol% is that it is neutral that these materials are considered to part when having contained the acidic group monomer with salifiable cation is neutral at least.Suitable salifiable cation comprises alkali metal, ammonium, replacement ammonium and amine.Neutrally contain the percent that the acidic group monomer accounts for employed total monomer and be called " degree of neutralization ".The degree of neutralization of the absorbent gelling materials that is purchased generally is about 25%-90%.

Above-mentioned sucting wet gel material generally uses with discrete particle form.These sucting wet gel materials can be any required shapes, as ball or semi-round ball, cube, bar-shaped polyhedron etc.Having the shape of big greatest dimension/smallest dimension ratio such as pin or thin slice also can consider with in the present invention.Also can use sucting wet gel material agglomeration of particles body.

The particulate big I of sucting wet gel material changes in very wide scope.Because industrial hygiene, particle mean size is not ideal during less than about 30 microns.Minimum dimension also may cause sensation gritty greater than the granule of 2mm approximately in absorbent device, see that from the viewpoint of user's aesthetics this is undesirable.In addition, granularity may influence fluidic infiltration rate.It is a lot of that bigger granule descends infiltration rate.The present invention preferably uses whole basically particulate granularities to be about 30 microns sucting wet gel material granules to about 2mm.The weighted mean of representing the minimum dimension of individual particle among the application with " granularity ".

In the articles for use of the present invention, especially the particulate consumption of the sucting wet gel material in the disposable absorbent article is generally 5gm ^-2-250gm ^-2, preferred 7gm ^-2-150gm ^-2, more preferably 10gm ^-2-100gm ^-2

Absorbent gelling materials is used in cationic polysaccharide of the present invention and is suitable above the stink controlling agent, because it can further strengthen benefit of the present invention.In fact, absorbent gelling materials has strengthened the cationic properties of cationic polysaccharide, thereby strengthens its stink control performance.Do not wish to be fettered, think that the negative charge anionic group of absorbent gelling materials is protonated with cationic polysaccharide, thereby improve cationic properties as deacetylation chitosan material by any theory.

Advantageously, in absorbent device be that the synthetic anionic sucting wet gel material (degree of neutralization is generally 25%-90%) described in the application is added to cationic polysaccharide particularly above the deacetylation chitosan material time with absorbent gelling materials, it is not only to water but also particularly to containing electrolytical solution as have outstanding fluid absorbency through liquid.

In addition, cationic polysaccharide in absorbent device particularly uses absorbent gelling materials above the deacetylation chitosan material when being synthetic anionic sucting wet gel material (degree of neutralization is generally 25%-90%) described in the application, and it has high gel strength in the absorption fluids process.In fact, this combination can improve the absorbability under the loading condition, can reduce back and wet and drench, and has therefore improved comfortableness.

Advantageously, when on odor control system of the present invention, having the agent of synthetic anionic absorbent gelling, produce best absorption of fluids and best stink control performance to general relevant stink with body fluid.

Disposable absorbent article

Can be with odor control system (promptly with any method well known in the art, at least a cationic polysaccharide and a kind of stink controlling agent) and optional absorbent gelling materials join in the absorbent device, for example be laminated on the core of absorbent device or be blended in the absorbent article core fiber.

Cationic polysaccharide and stink controlling agent preferably are added between the two layers of cellulose thin paper.For example, can randomly cationic polysaccharide and stink controlling agent be bonded between the two layers of cellulose thin paper with disclosed hot-melt adhesive among the WO94/01069 or any suitable bonding system.

In one embodiment of the invention, according to disclosed method among WO94/01069 or the disclosures in Italian patent application TO93A001028 cationic polysaccharide and stink controlling agent are added in the layer structure.The layer structure of describing among layer structure of describing among the TO93A001028 and the WO94/01069 is basic identical, and difference is in the layer structure of describing in TO93A001028, fibrous layer (120gm ^-2) between the intermediate layer in the very large sucting wet gel material of the amount of comprising, this sucting wet gel material adds as optional components in the present invention.The intermediate layer is particularly including the polyethylene powders as thermoplastic material, and polyethylene powders and stink controlling agent and cationic polysaccharide mix.Heat this mixture then, make the polyethylene fusing, laminate layer is sticked together.Line of adhesive preferably also is positioned at the edge of laminate, is bonded together with the edge of guaranteeing laminate, can not make wherein any loose cationic polysaccharide powder and stink controlling agent powder fall the laminate outside.

A kind of alternative is to be that those glue of H20-31  substitute polyethylene powders laminate layer and/or component are sticked together with traditional glue as the trade mark that is purchased from ATO Findley.The advantage of this method is a heating steps essential when having avoided the use polyethylene powders.

Cationic polysaccharide and stink controlling agent can be evenly be distributed on the whole absorbent device unevenly or one deck at least of top flat in or in one deck at least of egative film or in one deck at least of core or its any mixing.Cationic polysaccharide and stink controlling agent can be evenly or are distributed in unevenly on the whole surface of required one or more layers, perhaps are distributed in (as: edge of the center of absorbent device and/or surrounding zone such as layer) or mixed distribution on one or more zones of surface layer/a plurality of surface layers that apply cationic polysaccharide and stink controlling agent.

Cationic polysaccharide and stink controlling agent can be placed in the same position (as layer) together, also can be placed apart in diverse location/layer.For example, in one embodiment of the invention, the position of stink controlling agent (as zeolite and/or cyclodextrin and/or EDTA) is to make at least a portion fluid/ejection at the contact cationic polysaccharide, contacts the stink controlling agent before the preferred deacetylation chitosan material earlier.The stink controlling agent preferably places towards the in-core of top flat or places in the top flat (preferably auxiliary top flat) itself, and the position that cationic polysaccharide is placed is compared apart from top flat farther with the stink controlling agent.In one embodiment of the invention, the stink controlling agent is placed at least one top flat layer, and the cationic polysaccharide that is generally deacetylation chitosan material places in-core.In another embodiment of the invention, stink controlling agent and cationic polysaccharide all place in-core, but cationic polysaccharide is below the stink controlling agent, and cationic polysaccharide is generally towards egative film.In another embodiment, the stink controlling agent places in the absorbent article core, and cationic polysaccharide places in the egative film (preferred auxiliary film) itself.

In having the preferred embodiment of the invention of sucting wet gel material, the position of sucting wet gel material and stink controlling agent is that at least a portion body fluid/ejection was contacted with described sucting wet gel material and stink controlling agent before contacting cationic polysaccharide.In highly preferred embodiment of the present invention, sucting wet gel material and stink controlling agent place in the absorbent article core, the cationic polysaccharide that is generally deacetylation chitosan material also places in the absorbent article core, but the position that cationic polysaccharide is placed is compared apart from top flat farther with sucting wet gel material with the stink controlling agent.At absorbent article core is when making with two cellulose thin paper laminates, sucting wet gel material and stink controlling agent be clipped in this two-layer between, cationic polysaccharide is applied on the layer of position near egative film, preferably on the inboard of this layer, with near sucting wet gel material and stink controlling agent.These measures promptly, have best stink and fluid absorbency and retention without any leaking or return under the wet situation about taking place in conjunction with best stink control performance and best fluid handling properties advantageous particularly.Cationic polysaccharide is because be improved its cationic properties near sucting wet gel material.In addition, cationic polysaccharide has the trend of formation towards the so-called impermeable barrier of egative film owing to having gelling property, thereby has prevented any leakage.

In absorbent device, if cationic polysaccharide and stink controlling agent and exist and to comprise that also optional absorbent gelling materials can add with powder, particle form, also can with as the form spraying that contains the solution of polysaccharide and/or contain the solution of stink controlling agent add.When using with particle form, cationic polysaccharide (as deacetylation chitosan material) and stink controlling agent and optional absorbent gelling materials granulating respectively mix also granulating together then.

In the preferred embodiment of the invention, disposable absorbent article generally is following articles for use:

Absorbent article core

According to the present invention, absorbent article core can comprise following parts: (a) optional main fluid Distribution Layer preferably combines with optional secondary fluid Distribution Layer; (b) fluid storage layer; (c) the optional fiber that stores below the layer (" bottoming " (dusting)) layer of being positioned at; And (d) other optional feature.According to the present invention, the thickness of absorbent article core depends on its final use.

A. Master/secondary fluid Distribution Layer

An optional feature of absorbent article core of the present invention is main fluid Distribution Layer and secondary fluid Distribution Layer.This main Distribution Layer be usually located at the following of top flat and with the top flat fluid communication.Top flat is used for final assignment for this main Distribution Layer the FLUID TRANSPORTATION of collecting and gives the storage layer.Liquid not only carries out along thickness by the conveying of main Distribution Layer, and carries out along the length and the width of absorbent product.Also be choose wantonly but preferred secondary fluid Distribution Layer be usually located at the following of main Distribution Layer and with main Distribution Layer fluid communication.The purpose of this secondary fluid Distribution Layer is to be easy to collect fluid from main Distribution Layer, and it is transported to following storage layer rapidly.This helps the making full use of of fluid displacement of following storage layer.Fluid distribution layer can be made of any material that is generally used for this class Distribution Layer.Particularly, fibrous layer capillaceous can be used as Distribution Layer between fiber even also keep when humidity.

B. The fluid storage layer

The fluid storage layer be usually located at main or secondary Distribution Layer below, and with they fluid communication.This fluid storage layer can comprise cationic polysaccharide and optional absorbent gelling materials.It comprises preferably and bonded cationic polysaccharide of suitable carriers and optional absorbent gelling materials.

Suitable carriers comprises that routine is used for the material of absorbent structure, as natural, modification or synthetic fibers, particularly is the modification of fine hair and/or thin paper form or the cellulose fibre of non-modification.Concerning sanitary towel and pantiliner, most preferably thin paper or thin paper laminate.

An embodiment of absorbent structure prepared in accordance with the present invention comprises multilamellar, comprises usually thin paper itself is folding and double-deck thin paper laminate that form.For example can these layers be connected to each other with binding agent or mechanical interlocking or hydrogen bridge band.Cationic polysaccharide (with the stink controlling agent) and optional absorbent gelling materials can be included between these layers.

Can also use the cellulose fibre of modification, as stiffening cellulose fibre.Also can use synthetic fibers, comprise those synthetic fibers of making by following material: cellulose acetate, polyvinyl fluoride, polyvinylidene chloride, acrylic compounds (as Orlon), polyvinyl acetate, insoluble polyvinyl alcohol, polyethylene, polypropylene, polyamide (as nylon), polyester, bicomponent fibre, tricomponent fibre and composition thereof etc.Preferably, fiber surface is hydrophilic or is processed into hydrophilic.Store layer and can comprise that also filler as perlite, kieselguhr, Vermiculitum etc. is to improve liquid retention.

Be dispersed in the carrier if cationic polysaccharide and optional absorbent gelling materials are non-homogeneous, storing layer can be local uniform, promptly has distribution gradient on one or several direction in the size range that stores layer.Non-uniform Distribution also can refer to partly or entirely surround the carrier laminate of cationic polysaccharide and optional absorbent gelling materials.

C. Optional fiber (" bottoming ") layer

An included optional feature of absorbent article core of the present invention is near storing layer, common fibrous layer below storing layer.This lower floor fibrous layer is commonly referred to as " bottoming " layer, because it provides substrate for the sucting wet gel material in the deposition storage layer in the process of producing absorbent article core.In fact, be at sucting wet gel material under the situation of macrostructure such as fiber, sheet or strip, do not need to contain this fiber " bottoming " layer.But, should can provide the fluidic ability of some additional processing as length direction fast Absorption fluid by " bottoming " layer along pad.

D. Other optional feature of absorbent structure

Absorbent article core of the present invention can comprise other optional feature that exists usually in the moisture absorption net.Rare gauze (scrim) of reinforcement for example, can be set in each layer of absorbent article core or between each layer.The configuration of rare gauze that this class is strengthened should be unlikely to form the interface barrier of FLUID TRANSPORTATION.If when having the structural integrity that occurs usually as the heat bonding result, concerning the absorbent structure of heat bonding, it is normally unwanted that this strengthens rare gauze.

Top flat

According to the present invention, absorbent device comprises the top flat as necessary component.Top flat can comprise single or multiple lift.In a preferred embodiment, top flat comprise provide top flat towards the ground floor on wearer surface and be in ground floor and absorbent structure/absorbent article core between the second layer (being also referred to as auxiliary top flat).

Top flat is an integral body, so each monolayer all must be submissive, soft feel and non-stimulated to wearer's skin.Top flat also can have elastic performance, makes it extensible on one or two direction.According to the present invention, top flat can be made by any material that is purchased that can reach the object of the invention well known in the art, as weaving and adhesive-bonded fabric and film.

In the preferred embodiment of the present invention, at least one layer of top flat, preferably its upper strata comprises hydrophobic liquid-tight apertured polymeric film.Preferably, the upper strata can promote liquid from providing to the membrane material in the hole that absorbent structure transmits towards the wearer surface by having.If have lower floor, then lower floor preferably includes the thin paper of nonwoven layers, porous formed film or air lay.

Term porous polymer top flat among the application represents to comprise the top flat of at least one layer or a plurality of layers, and wherein at least one layer is to be formed by continuous or unbroken membrane material, forms the hole in membrane material.We are surprised to find: compare with the pre-sheet of other kinds such as the non-woven material of hot adhesion, the porous polymer top flat has better stink control performance.

In general, porous polymer top flat of the present invention is submissive, soft feel and non-stimulated to wearer's skin.In addition, top flat is fluidic, and fluid (as through liquid and/or urine) is easy to by its thickness infiltration.Be applicable to that porous polymer top flat of the present invention comprises the thermoplastic film of polyalcohol stephanoporate formed film, thermoplastic film, porous plastic membrane and hydroforming; Porous foam; Reticulated polymer foam and thermoplastic film; And the rare gauze of thermoplastic.

The top flat that the present invention preferably uses is selected from porous formed film top flat.It is that they can see through bodily exudate that porous formed film is preferred for topsheet because, and does not absorb them, and liquid is returned and the trend of returning wet wearers skin reduces.Therefore, keep dry, therefore reduce health and stain, for the wearer provides a more comfortable sensation with the surface of the formed film of Body contact.Suitable formed film is described in the following patent: the US5006394 (Baird) that the US4463045 that the US4342314 that the US4324246 that US3929135 (Thompson), the 1982.4.13 that 1975.12.30 authorizes authorizes people such as () Mullane, 1982.8.3 authorize people such as () Radel, 1984.7.31 authorize people such as () Ahr, 1991.4.9 authorize.Introduce these patents herein all as a reference.The preferred top flat of the present invention be in above-mentioned one or more patents, describe and by The Procter﹠amp; Gamble Company (Cincinnati, Ohio) formed film of in sanitary towel, selling with " DRI-WEAVE ".

Be applicable to that the top flat in the three-dimensional film field is described among EP0018020 and the EP0059506.The hole that particularly preferred three-dimensional polymer top flat has the regular pentagonal shape, these hole gauges then distribute, and hole size is 0.41mm ²These lateral separations, hole are 0.37mm, longitudinal separation 0.25mm.The initial perforate of this top flat (before being shaped) thickness is about 25mm, and final thickness (back is shaped) is about 0.53mm, and aperture area is 25% to about 40%.

Another kind of particularly preferred formed film top flat is the top flat that its perforate has two kinds of shapes, and area is about 0.21mm ²Regular pentagonal and area be 1.78mm ²Irregular hexagon.The distribution situation of perforate is that the distance between the both sides of this structure is that about 0.37mm is to about 0.42mm.Before being shaped and the film thickness after being shaped be respectively 0.25mm and 0.43mm.The hole area of this film is about 33.7%.These two kinds of films all are according to the instruction of above-mentioned patent preparation.

The top flat of the third suitable form comprises two independences but the perforated polymeric films of mutual superposition.

Thereby the body surface of formed film top flat of the present invention also can be hydrophilicly to transmit by top flat quickly when helping the flowing fluid ratio body surface not to be hydrophilic.Eliminated the probability that will flow out top flat rather than flow into absorbent structure and be absorbed in this way through liquid.In a preferred embodiment, surfactant is joined in the polymeric material of formed film top flat, this is described in the U.S. Patent application 07/794745 in the 1991.11.19 application as people such as Aziz, in " Absorbent Article HavingA Nonwoven and Apertured Film Coversheet ", introduce this document herein as a reference.A kind of alternative is the body surface of top flat to be handled that it is become is hydrophilic with surfactant, as described in above-mentioned US4950254, introduces this patent herein as a reference.

Egative film

The main effect of egative film is to prevent from the absorbent structure to absorb to get wet with the ejection that retains to contact the article of absorbent device, as underwear, trousers, nightwear and underwear.Egative film is liquid-tight (as: through liquid and/or urine) preferably, and preferably makes with plastic sheeting, although also can use the liquid-tight material of other pliabilities.Represent that with term " pliability " this material is softish among the application, and be easy to consistent with profile phase with body shape.Egative film also can have elasticity, and it can be stretched on one or two direction.In a preferred embodiment, egative film comprise provide egative film towards the medicated clothing surface ground floor and be in ground floor and absorbent structure/core between the second layer (being also referred to as auxiliary film).

Egative film generally extends through whole absorbent structure, and can stretch into or form the part or all of of preferred flank, side packaging components or fin.

Egative film can comprise the non-woven material of weaving or non-woven material, polymeric membrane such as polyethylene or polyacrylic thermoplastic film or composite such as plated film.Egative film preferably thickness is generally the polyethylene film of about 0.012mm (0.5mil) to about 0.051mm (2.0mil).

Exemplary polyethylene film is Clopay Corporation of Cincinnati Ohio production, the trade mark is P18-040 1 and Ethyl Corporation, Visqueen Division, of Terre Haute, Indiana produces, and the trade mark is XP-39385.Preferably the outward appearance that more resembles cloth to produce is handled in egative film embossing and/or delustring.In addition, egative film can allow steam effusion absorbent structure, is breathability, but can prevent again that ejection from passing through egative film simultaneously.Can also use breathability egative film such as film which floor comprises to add non-woven constructions.

Be applicable to that breathability egative film of the present invention comprises all breathability egative films well known in the art.The breathability egative film is divided into two classes in principle: ventilative but liquid-tight monolayer breathability egative film and have two-layer egative film at least has at least two-layer egative film that breathability and opaque liquid are combined.

Be applicable to that monolayer breathable backsheet of the present invention comprises those as describing in GBA2184389, GBA2184390, GBA2184391, US4591523, US3989867, US3156242 and EP application number 95120653.1.

Be applicable to that bilayer of the present invention or multi-layered gas-permeable egative film are included in those that are exemplified in US3881489, US4341216, US4713068, US4818600, EPO203821, EPO710471, EPO710 472, the European Patent Application No. 95120647.3,95120652.3,95120653.1 and 96830097.0.

The egative film that satisfies defined requirement in the European Patent Application No. 96830343.8 is particularly preferred, and more preferably wherein absorbent device also satisfies wherein said requirement.

According to the present invention, the breathability egative film comprises at least one, preferably at least two water vapor permeable layers.Suitable water vapor permeable layers comprises film and the porous formed film that 2 dimensional plane apertures and macroporous membrane, monolithic membrane, macroscopic view are expanded.According to the present invention, the hole in the described layer can be an Any shape, but preferred sphere or rectangle.The size in these holes can also change.In a preferred embodiment, these holes preferably are evenly distributed on the whole surface of this layer, and still, its surface only has the interior foraminous layer in some zone to be also included within protection scope of the present invention.

The average diameter in the hole of the 2 dimensional plane films that use among the present invention is the 5-200 micron.The average diameter that is applicable to the hole of 2 dimensional plane microporous membranes of the present invention is generally the 150-5 micron, preferred 120-10 micron, most preferably 90-15 micron.The average diameter in the hole of typical 2 dimensional plane macroporous membranes is generally the 200-90 micron.The average diameter that is applicable to the hole of macroscopical film of expanding of the present invention and porous formed film is generally the 100-500 micron.Egative film comprises in embodiment of the present invention of the film of macroscopic view expansion or porous formed film therein, and the perforated area of egative film is generally greater than 5% of egative film total surface area, preferred 10%-35%.

2 dimensional plane layers of suitable egative film can be made with any material well known in the art, but preferred with the polymeric material production that generally is purchased.Known GORE-TEX (TM) or Sympatex (TM) the section bar material that is used for so-called breathability cloth in the capable territory of suitable examples of material.Other suitable material comprises Minnesota Mining and Manufacturing Company, St.Paul, Minnesota, the XMP-1001 that USA produces.The term 2 dimensional plane layers that use among the application are represented the degree of depth less than 1mm, and preferably less than the layer of 0.5mm, hole wherein has average homogeneous on its length direction diameter and these Kong Buhui are projected into outside the plane of this layer.Can produce the porous material that is used as egative film of the present invention with the method described in any method well known in the art such as EPO 293482 and the citing document thereof.In addition, can be by on the plane of backsheet layer, applying the size that pulling force (this layer promptly stretches) increases the hole that produces with this method.

Suitable porous formed film comprises the film with a plurality of discrete hole, these holes reach towards the layer of core outside the horizontal plane on the surface of medicated clothing, thereby the projection of formation.These projectioies are porose in its end.Described projection is funnel shaped preferably, is similar to the shape described in the US3929135.The hole that is positioned at the plane can be that circle also can not be circular with the hole that is positioned at protruding end own, but the cross sectional dimensions in the hole at projection terminal place or area should be less than the cross sectional dimensions or the areas towards interior hole, the surface of medicated clothing of this layer.Described porous formed film is preferably unidirectional, is not all also to want most of along a direction transmission to core even make fluid.Be applicable to that macroscopical film of expanding of the present invention comprises the film described in US637819 and US4591523.

Suitable monolithic membrane comprises the Hytrel that can be purchased from DuPont Corporation USA ^TMAnd as Index 93 Congress, Session 7A " Adding Value to Nonwovens ", J-C.Cardinal andY.Trouilhet, DuPont de Nemours International S.A., other material described in the Switzerland.

According to the present invention, except that described water vapor permeable layers, egative film can also comprise the additional bottom sheet layer.Described extra play can place on the side of described water vapor permeable layers of egative film.Extra play can be any material, as fibrous layer or additional water vapor permeable layers above.

Stink control test

With the minimizing situation of measuring stink as external olfactory test (in vitro sniff test).External olfactory test is by expert's level classification person the relevant stink of the articles for use that comprise composition to be tested (comprising with reference to articles for use) when contacting with the solution that contains malodor components to be analyzed.

Expert's level classification person expresses their judgement to (no) happy degree of stink with (no) happy rank, and-10 (the least Yu Kuai degree) that are generally are to 5 (the happiest degree).Each classification person compares the MU in the test section (displeased rapidity) with this method.Relative MU odor values to different product is carried out label.For example, the taste of realizing a kind of sample in test section is 2 times of another kind of sample, then is denoted as 2 times of big numerical value.A kind of taste of sample is 1/10th of an another kind of sample, then is denoted as 1/10th big numerical value, or the like.In each test section, represent neutral happy degree, use on the occasion of representing the relative happy degree of stink and the ratio of displeased rapidity with negative value with 0.

The external inner olfactory test that carries out with the solution that contains inner malodor components that reproduces through the necessary stink performance of liquid shockingly shows: when with chitosan of the present invention (as Kytamer PC Chitosan PCA (Kytamer )) and stink controlling agent (as: zeolite A, its trade mark that can be purchased from Degussa AG is Wessalith CS or edetate (BASF) or hydroxypropyl (Fluka)) with use a kind of of these two kinds of compositions to compare separately with identical active substance total amount, have collaborative minimizing stink effect.In fact, the percent that reduces of the displeased rapidity that obtains with this mixture is higher than the percent that the displeased rapidity that obtains when using this two kinds of compositions a kind of separately with identical active substance total amount reduces.For each sample, the displeased rapidity value that obtains all is the meansigma methods of at least 15 (3 products, 5 classification persons) test values.These results are significant statistically.

Also can measure the minimizing situation of stink with olfactory test in the body, this is described among patent application EP-A-811387 or the WO97/46191, introduces these files herein as a reference.

Further specify the present invention below by embodiment.

Embodiment

Embodiment A:

The women of Shi Yonging is by Procter﹠amp with protective pad in the following embodiments; The Always (Always is a kind of registered trade mark) that Gamble Germany sells.

With following method each women is taken apart with protective pad: sever packing around the covering with holes at place, bottom surface of basic longitudinal edge along the separate paper that covers outside tack coat.Remove fluid-tight plastic bottom layer then gently, come out in the side of water absorbent fiber core, then along with the parallel plane plane of protective pad itself with fibre core in two, each thickness partly is basic identical.Deacetylation chitosan material and stink controlling agent are evenly distributed between these two fibrous layers.

Then egative film in fluid-tight is put back into its original position, with as two-sided tape along myometrial suture covering with holes packing on every side.

The chitosan power material that uses is the Kytamer PC Chitosan PCA of 0.2g, and this is from Amerchol Corporation, Edison, and New Jersey is purchased, and its product are called Kytamer  PC.

The stink controlling agent that uses is the zeolite A of 0.3g, and this can be purchased from Degussa AG, and its trade mark is Wessalith CS.

Embodiment B

Produce other protective pad according to the method for embodiment A, the stink controlling agent that difference is to use is a cyclodextrin, rather than zeolite.The cyclodextrin that uses is the 0.1g hydroxypropyl that can be purchased from Fluka.

Embodiment C

Produce other protective pad according to the method for embodiment A, the stink controlling agent that difference is to use is a chelating agen, rather than zeolite.The chelating agen that uses is the 0.1g edetate that is purchased from BASFAG.

Embodiment D, E and F

Produce other protective pad according to the method for embodiment A, B and C respectively, difference is the deacetylation chitosan material and stink controlling agent that uses separately in embodiment A, B and C, also sucting wet gel material (AGM) is evenly distributed between these two fibrous layers.

The AGM that uses is the 0.4g cross-linked sodium polyacrylate XZ9589001 that can be purchased from DOW Chemicals.

Embodiment G, H and I

Produce other protective pad according to the method for embodiment A, B and C respectively, difference be with fibre core in two after, each self-defining stink controlling agent among sucting wet gel material (AGM) and embodiment A, B and the C is evenly distributed in respectively between this two and half fibrous layer, and deacetylation chitosan material is evenly distributed on following that half fibrous layer (that is, in case with the layer of the protective pad egative film of more close reconstruct).Be actually preparation deacetylation chitosan material solution, it is sprayed on following that half fibrous layer inboard equably.

Prepare chitosan soln with following method: the 1g Kytamer PC Chitosan PCA that will be called Kytamer  PC from the product that Amerchol Corporation is purchased is dissolved in the 100g distilled water, stirs a night down at 40 ℃.With the solution spray of 10g preparation (that is protective pad 0.1g chitosan) on that half fibrous layer below.

The AGM that uses is the cross-linked sodium polyacrylate (code name: XZ9589001) that can be purchased from DOW Chemicals of 0.4g.

The stink controlling agent that uses is the stink controlling agent (kind and consumption) that defines in embodiment A, B and C respectively.

Therefore, embodiment G, H have different stink controlling agents with the various protective pad that I prepares respectively, and these stink controlling agents correspond respectively to the stink controlling agent that uses among the foregoing description A, B and the C.

Embodiment J

Be based on Procter﹠amp with in the following embodiments women with pantiliner; Gamble, the pantiliner of the modification of the Always " Alldays Duo Active " that Germany produces.Top flat is that { the film vendor code is BPC 5105 CPM BP Chemical Germany to film/non-woven composite, and the non-woven fabrics vendor code is ARBO TB/BI M equinenza S pain}.Core material is by the two-layer quantitative 55g/m that is ²The thin paper laminate that constitutes of the thin paper (can be purchased from Unikay Italy, vendor code is Unikay 303 LF) of air lay (13.2cm * 4.0cm).Between two-layer thin paper, laminate contains deacetylation chitosan material and stink controlling agent.

Egative film comprises ground floor and two layers of the second layer.Ground floor contacts with the second layer with the moisture absorption thin paper.The second layer contacts with ground floor and wearer's underwear.Ground floor is that { by Tredegar FilmProducts B.V.Holland supply, producing code is the porous formed film (CPT) that X-1522} makes with low density PE.The second layer by nonwoven fabric laminate by the 13MB/16SB that the Corovin GmbH of Germany produces, product MD 2005} formation by name.Nonwoven fabric laminate is by 16g/m ²Spunbond thing and 13g/m ²The thing that melts and sprays constitute.Quantitatively be about 8g/m by applying ²Degree of depth stack spiral glue and each backsheet layer all is connected on whole surface.Be used to connect the glue of two backsheet layers by SAVARE ' SpA.Italy supply (material code is PM17).

The deacetylation chitosan material that uses is the Kytamer PC Chitosan PCA of 0.2g, and this is from Amerchol Corporation, Edison, and New Jersey is purchased, and its trade mark is Kytamer  PC.

The stink controlling agent that uses is 0.3g zeolite A, and this can be purchased from Degussa AG, and its trade mark is Wessalith CS; Also can use the 0.1g hydroxypropyl that is purchased from Fluka; Can also use the 0.1g edetate (EDTA) that is purchased from BASFAG.

Can begin to prepare other pantiliner from the illustration protective pad of the foregoing description J, difference is added to deacetylation chitosan material and above the stink controlling agent at AGM.In fact, this three constituents can mix equably and obtain being evenly distributed on the powder of laminate between two-layer.The AGM that uses is the crosslinked sodium polyacrylate (code name: XZ 9589001) of 0.4g that is purchased from DOW Chemicals.

All above-mentioned illustrative protective pad all have outstanding stink control performance with the pantiliner pair malodorous compounds relevant with body fluid.

Claims

1, a kind of articles for use, it comprises cationic polysaccharide and stink controlling agent as odor control system, this system is used to control stink, the preferred control stink relevant with body fluid.

2, according to the articles for use of claim 1, wherein, cationic polysaccharide is an aminopolysaccharide, deacetylation chitosan material preferably, and this deacetylation chitosan material generally is selected from the chitosan of chitosan, chitosan salts, modification, crosslinked chitosan and composition thereof.

3, the articles for use that require according to arbitrary aforesaid right, wherein, described cationic polysaccharide is a deacetylation chitosan material, and its degree of deacetylation is greater than 75%, and preferred 80% to about 100%, even more preferably 90%-100%, and most preferably 95% to about 100%.

4; articles for use according to arbitrary aforesaid right requirement; wherein; deacetylation chitosan material is a chitosan salts; it generally is chitosan salts of following acid and composition thereof: citric acid; formic acid; acetic acid; acetylaminoacetic acid; aspirin; fumaric acid; glycolic; iminodiacetic acid; the itaconic acid; lactic acid; maleic acid; malic acid; nicotinic acid; salicylic acid; succinamic acid; succinic acid; ascorbic acid; aspartic acid; glutamic acid; 1,3-propanedicarboxylic acid; malonic acid; acetone acid; the sulfonyl oxalic acid; benzoic acid; Epoxysuccinic acid; adipic acid; thiodiglycolic acid; thioglycolic acid; alanine; valine; leucine; isoleucine; proline; phenylalanine; triptofane; methionine; glycine; serine; cysteine; tyrosine; agedoite; glutamine; lysine; arginine; istydine; hydroxyproline; the 2-pyrrolidone-5-carboxylic acid is more preferably Kytamer PC Chitosan PCA.

5, the articles for use that require according to arbitrary aforesaid right, the cationic polysaccharide that it is contained or the amount of its mixture are 0.5gm ^-2-500gm ^-2, preferred 1-200gm ^-2, more preferably 3gm ^-2-100gm ^-2, 4gm most preferably ^-2-50gm ^-2

6, the articles for use that require according to arbitrary aforesaid right, wherein, the stink controlling agent is chelating agen and/or odor absorbent.

7, the articles for use that require according to arbitrary aforesaid right, wherein, described stink controlling agent is an odor absorbent, this odor absorbent is selected from zeolite, charcoal, kieselguhr, starch, cyclodextrin and derivant thereof, kieselguhr, clay, ion exchange resin and compositions thereof, preferred zeolite, alpha-cyclodextrin, beta-schardinger dextrin-, gamma-cyclodextrin or derivatives thereof or its compositions.

8, the articles for use that require according to arbitrary aforesaid right, wherein, described stink controlling agent is a chelating agen, this chelating agen is selected from aromatic chelating agent, other chelating agen such as the ethylenediamine N of phosphine acid salt chelator, amino phosphonates do chelating agen, polyfunctional group replacement, N '-disuccinic acid, aspartic acid, glutamic acid, malonic acid, glycine and composition thereof.

9, articles for use according to Claim 8, wherein, chelating agen is selected from edetate, triacetate, diacetin and an acetate; Ethylenediamine N, N '-disuccinic acid, ethylenediamine five (methylene phosphonic acid), ethylenediamine tetraacetic (methylene phosphonic acid) and composition thereof, more preferably edetate.

10, the absorbent device that requires according to arbitrary aforesaid right, the stink controlling agent that it is contained or the amount of its mixture are 1gm ^-2-600gm ^-2, more preferably 5gm ^-2-400gm ^-2, 10gm most preferably ^-2-200gm ^-2

11, the absorbent device that requires according to arbitrary aforesaid right, it also contains sucting wet gel material, preferably the synthetic sucting wet gel material of anion.

12, according to the articles for use of claim 11, wherein, the amount of sucting wet gel material or its mixture is 5gm ^-2-250gm ^-2, preferred 7gm ^-2-150gm ^-2, more preferably 10gm ^-2-100gm ^-2

13, the articles for use that require according to arbitrary aforesaid right, wherein, described articles for use are disposable absorbent articles, preferably sanitary towel, pantiliner, tampon, diaper, incontinence pad, breast pad, hidroschesis pad, human or animal's waste reduction and disposal equipment, interlabial pad or clean body articles for use.

14, the articles for use that require according to arbitrary aforesaid right, wherein, described articles for use are disposable absorbent articles, this disposable absorbent article comprises liquid top flat, egative film and the absorbent article core between described egative film and described top flat.