CN1435228A - Use of American ginseng spray in treating recurring mouth ulcer - Google Patents

Abstract

An American ginseng spray for treating recurrent oral ulcer is disclosed. Its advantages are high curative effect and low cost.

Description

The application of Radix Panacis Quinquefolii spray in the treatment recurrent oral ulceration

Technical field: this product is used for the treatment of recurrent oral ulceration.Belong to clinical new drug development category.

Technical background: recurrent oral ulceration (being called for short ROU), claim A Fota ulcer again, be meant to have cycle recurrent characteristics, be the disease of feature with the infringement of oral mucosa limitation ulcer.This disease has self limiting, and natural history is 7-14 days.Sickness rate is higher, and the general crowd's prevalence of China is not less than 10% ^[1]Its pathogenesis is still very not clear and definite at present.Its pathogenesis is still very not clear and definite at present.Motherland's medical science thinks that this disease is a kind of oral cavity partial reaction of systemic disease, and is evil in close relations with " fire ".Modern medicine think ROU be by damage, stress, the disease that causes of multiple factors such as smoking, endocrine, heredity, immunity, infection, diet ^[2]This disease is outbreak repeatedly often, and symptom can gently can weigh, the lighter's mouth numbness discomfort, and weight person's sharp ache has a strong impact on diet and rest unbearably, brings huge misery.Recurrent oral ulceration, integrative therapy does not still have specific medicament at present.Although modern medicine employing hormone and immunomodulator treatment as transfer factor, thymosin etc., though truly have certain curative effect, because use is inconvenient or effect is not good, have limited clinical practice.At present China ROU adopts treatment by Chinese herbs more, as watermelon crystal, XILEI SAN, nourishing yin shengjisan etc., but these medicines not only mouthfeel is poor, absorb also slow.The normal residual black medicated powder of oral mucosa face forms " black mouth ", " black tongue ", make us very awkward, and curative effect is mostly not good, and is invalid substantially after using repeatedly.So make numerous ROU patient feel disappointed.So exploitation has that pain relieving is rapid, ulcer healing is fast, relapse rate is low, more effective, suitable anti-ROU medicine easy to use, characteristics such as the patient accepts is particularly important and urgent.

Radix Panacis Quinquefolii has another name called Radix Panacis Quinquefolii, and English name American ginseng originates in northern US and Canada, belongs to the araliaceae ginseng plant.Its sweet in the mouth, little hardship, cold in nature have and mend and not dry, grow and oiliness characteristics, and the effect of resolving heat and reducing pathogenic fire, YIN nourishing and QI supplementing, promoting the production of body fluid to quench thirst is taken as a kind of senior tonic, uses existing more than 300 year in China.Modern study thinks that except that above-mentioned effect, Radix Panacis Quinquefolii also has effects such as slow down aging, resisting fatigue, anti-hypoxia, enhancing body immunity.Recently studies show that: Radix Panacis Quinquefolii has pain relieving ^[3], improve endocrine ^[4], antifungal ^[5], anti-stress ^[6]Etc. function.Wang M ^[7]Not only can promote the leukocytic activity of engulfing in one of report Radix Panacis Quinquefolii main component CVT-E002 albumen, reduce inflammation, and can promote the generation of il-1, interleukin-6, tumor necrosis factor-a and NO, thereby stimulate revascularization, fibroblast propagation and collagen synthetic, promote ulcer healing.999 Radix Panacis Quinquefolii buccal tablets are used and shown, but Radix Panacis Quinquefolii through port transmucosal capillary network absorbs directly into blood, absorb rapidly, and are rapid-action, and its effect improves more than three times than the tradition method of swallowing.More than these characteristics provide theoretical foundation for Radix Panacis Quinquefolii spray treatment ROU.Process I and other people is used repeatedly and is shown, said preparation alleviating pain, promotion ulcer healing, reduction rapidly recurs frequency, and therefore test basis of the present invention is reliable.Unfortunately, although Radix Panacis Quinquefolii has above advantage, still there is not the treatment that any Radix Panacis Quinquefolii preparation is used for clinical ROU at present.So the Radix Panacis Quinquefolii spray treatment ROU that development of new is suitable for is not only feasible, and have broad application prospects.

Summary of the invention: this product is made fine powder with exsiccant Radix Panacis Quinquefolii, and packing into has in the plastic bottle of osculum conduit.Plastic bottle soft or hard appropriateness is convenient to squeeze, 1 millimeter of conduit diameter.Squeeze plastic bottle gently, medicated powder is sprayed at ulcer surface, every day 4 times, during serious symptom, can spray for several times.

This product has overcome the deficiency of anti-recurrence stomatocace medicine in the past, makes full use of this preparation advantage and a kind of novel anti stomatocace medicine of developing.Its advantage is as follows:

1. Radix Panacis Quinquefolii medicated powder white is slightly yellow, sweet in the mouth, and mouthfeel is good, can be sprayed at ulcer surface and normal mucosa.The direct inlet port transmucosal of medicine capillary network absorbs soon, and onset is rapid.Its biological effectiveness than tradition swallow the method Senior Three doubly more than.

2. on pathogenesis, this medicine is not only from local analgesia, microcirculation improvement, promotion wound healing, and from the whole body angle by improve stress, leukocyte increasing, enhancing immunity, endocrine regulation function, YIN nourishing make the body recovery normal condition with approach such as fire, reduces the recurrence frequency.

3. this medicament mouthfeel is good, and anti-oral ulcer is effective, and has nourishing function concurrently, and it is extensive to be suitable for the crowd, does not have contraindication substantially, easy to use, easy for patients to accept, clinical having a extensive future.

4. China's Radix Panacis Quinquefolii aboundresources, all there is plantation in many mountain areas, and cost is cheap relatively.This medicament of a large amount of development and use, not only provide a kind of brand-new treatment approach for ROU, and the prosperity that promotes motherland's medical science is also play a part certain, can also promote the mountain area economy development, improve the life of farmers level, thereby can bring huge economic benefit and social benefit.

List of references

[1] Li Bingqi. practical Diseases of the Oral Mucosa. front page. the Sichuan science and technology .1987:93 of publishing house

[2]Semin?Cutan?Med?Surg.1997；16(4)：278-83

[3]Yang?JC，Pang?CS，Tsang?SF，Ng?KF.Am?J?Chin?Med.2001；29(1)：149-54

[4]Liu?J，Burdette?JE，Xu?H，et?al.J?Agric?Food?Chem.2001；49(5)：2472-9

[5]Wang?HX，Ng?TB.Biochem?Biophys?Res?Commun.2000；269(1)：203-8

[6] Tan De says, Qiu Haiqiang, Yuan Huinan. new Chinese medicine and clinical pharmacology .2000; 11 (4): 242-43

[7]Wang?M，Guilbert?LJ，Ling?L，et?al.J?Pharmacol.2001；53(11)：1515-23

Claims (4)

1. a treatment recurrent oral ulceration pharmaceutical preparation is characterized in that with the Radix Panacis Quinquefolii being main component.

2. according to claims 1 described product, it is characterized in that Radix Panacis Quinquefolii is made Powdered spray.

3. according to claims 1 described product, it is characterized in that directly acting on the canker sore face.

4. the Radix Panacis Quinquefolii spray is in the application of treatment recurrent oral ulceration.