CN1432356A - Prepn of biological regulating release capsule - Google Patents
Prepn of biological regulating release capsule Download PDFInfo
- Publication number
- CN1432356A CN1432356A CN 02110580 CN02110580A CN1432356A CN 1432356 A CN1432356 A CN 1432356A CN 02110580 CN02110580 CN 02110580 CN 02110580 A CN02110580 A CN 02110580A CN 1432356 A CN1432356 A CN 1432356A
- Authority
- CN
- China
- Prior art keywords
- capsule
- preparation
- soft capsule
- regulating release
- fatty acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Medicinal Preparation (AREA)
Abstract
The capsule of the present invention prepared with the capsule material made of several kinds of polymer material is extracorporteal water stable and intracorporeal swelled to split, so that it can be used for preparing sealed spherical or other shaped capsule with water or water solution of medicine as capsule core through conventional process. The present invention increases the form number of preparation and is favorable to medicine to take its effect. In addition, using the capsule to replace available one can reduce environmental pollution and material waste.
Description
Soft capsule in the market, be to use gelatin by animal skin or bone preparation as outer lapping (being called the capsule material), the decentralized photo of the flowing material (being called the capsule heart) that is contained in its capsule mainly is a vegetable oil, or other non-water substance, as (hereinafter to be referred as non-aqueous materials) such as Animal fat, PEG.And for being that the flowing material of medicine decentralized photo or main decentralized photo (comprising states such as true solution, Emulsion or emulsion, suspension, hydrogel, aqueous fluids or semifluid) is as the capsule heart (hereinafter to be referred as hydrous matter) with water, adopt external water-insoluble and solubilized or swelling in the body, the macromolecule filming material that bursts apart as the capsule material, the soft capsule that is prepared from, both the research bibliographical information appearred also not seeing in product-free.
Through inquiry " Chinese patent ", a relevant patent---" a kind of water-proof insoluble capsule [2] " (application number is 93107466) wherein, the method that it adopted is to be sprayed on the capsule material that uses soft capsule in the present production with water-insoluble macromolecular material, enables to seal the hydrous matter medicine.Looking and removing day is on November 20th, 1996.
Other has a patent of same purposes---" oral soft capsule that can be used for the decoction medicine " (application number is 90214944), the main method that it adopted is that the decoction medicine is placed water-insoluble material, only adopts medicinal binding material or binding piece to seal at opening part.This patent stopped on July 27th, 1994.
Initial purpose of the present invention is in order to overcome the some shortcomings part that this useful dosage form of Chinese medicine oral liquid is brought.Chinese medicine oral liquid has stronger advantage because of possessing the fast advantage of Chinese medicine decoction absorption on medicine and health-product market, but middle drug solns takes oral liquid formulation itself also can have many shortcomings, as: 1, owing to must adopt glass phial potting package, production cost height; 2, effective ingredient and impurity coprecipitation phenomena often take place owing to be difficult for thoroughly removing impurity in Chinese medicine oral liquid, cause user's misunderstanding easily when taking and cause the curative effect reduction; 3, most of Chinese medicine oral liquid mouthfeels are bad; 4, broken easily, transport, carry, take inconvenience; 5, depleted packaging material also are unfavorable for environmental protection or the like.Therefore, if to keep easily degree of being absorbed as of oral liquid, again Chinese medicine oral liquid is carried out concentrating of appropriateness, with the capsule heart of concentrated solution (Chinese medicine oral liquid of in fact most of 10ml packing specifications can be concentrated to the liquid concentrated solution of 1-2ml) as soft capsule, use capsule material of the present invention to be prepared into soft capsule, then above-mentioned many shortcomings can thoroughly be overcome.
Existing soft capsule is to be the capsule material with the gelatin, is the capsule heart with the flowing material of the non-aqueous dispersion phase of plant wet goods, adopts pressing or dropping preparation method to be prepared from.The material of not all flow regime all is suitable as its capsule heart, and some liquid state or room temperature that its scope of application is confined to not influence the physical and chemical stability of gelatin are semi-solid material down, as vegetable oil, PEG etc.For being the capsule heart of main decentralized photo with water,, obviously inapplicable owing to dissolving gelatin.
Adopt capsule material of the present invention, can Jiang Shui, be that the flowing material of main decentralized photo is as the capsule heart with water, be prepared into the hydrous matter soft capsule, not only stable under common storage requirement, and enter dissolving that can be in good time behind the organism (human gastrointestinal tract) or break, discharge and be present in capsule medicine in the heart.Its preparation method is similar to traditional soft capsule preparation, need not carry out equipment replacement.
The beneficial effect of capsule material of the present invention, except the dosage form problem that will solve Chinese medicine oral liquid described in the goal of the invention, in fact in the pharmaceutical preparation production practices, also have the more scope of application: those are stable to water, thereby the medicine that needs rapid release in vivo to help absorbing, Chinese medical concrete or half extract tablet, electuary, the solid preparation of Chinese medicine of oral medications such as powder, the chemicals that other is suitable, biotechnology class medicine, food, oral drugs such as health food, if adopt capsule material of the present invention, with these medicines with water be the flowing material of decentralized photo as the capsule heart, preparation becomes soft capsule.Then not only help this medicine rapid release in vivo, and because of it possess a lot of preparation formulation advantages (as applied widely, the Production and Packaging cost is low, good looking appearance, carry taking convenience, improve bioavailability, absorb rapid-action, can cover the adverse drug taste, reduce formulation preparation energy consumption or production cost, minimizing environmental pollution etc.).These medicines are prepared into soft capsule dosage form if use material of the present invention, then can obviously strengthen the market competitiveness of these pharmaceutical preparatioies.
Claims (5)
1. soft capsule with biological controllability.It is characterized in that this soft capsule is stable to water under external environment, not swelling, do not break, disintegratable discharges medicine under the gastrointestinal environment in vivo.
2. the described biological regulating release capsule of claim 1, the prescription of used capsule material consist of following pharmaceutic adjuvant by the certain number and the combination of amount: the polyvinylpyrrolidone of polyacrylic resin class, the cellulose family that contains various modification groups, different molecular weight, various alkyl acrylate acid esters, various fatty acid and fatty acid ester thereof; Other natural macromolecular material, as: starch based, alginic acid and its esters, various vegetable and animals oils and fatty acid ester thereof, different molecular weight polyethylene glycol (PEG) etc.And other pharmaceutic adjuvant that in this combination, adds some other not appreciable impact capsule material characteristics, as common plasticizer, opacifier, coloring agent etc.
3. the described biological regulating release capsule of claim 1, the end formulation composition of its capsule material belongs to medical auxiliary material all to the human body nonhazardous.
4. the described biological regulating release capsule of claim 1, its preparation of soft capsule method comprises traditional pressing and dropping preparation method, also comprises other novel preparation methoies such as air-flow or liquid stream interrupted injection seasoning.
5. the size and the color and luster of its profile of soft capsule of the present invention, volume are regardless of.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 02110580 CN1432356A (en) | 2002-01-18 | 2002-01-18 | Prepn of biological regulating release capsule |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 02110580 CN1432356A (en) | 2002-01-18 | 2002-01-18 | Prepn of biological regulating release capsule |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1432356A true CN1432356A (en) | 2003-07-30 |
Family
ID=27628197
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 02110580 Pending CN1432356A (en) | 2002-01-18 | 2002-01-18 | Prepn of biological regulating release capsule |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1432356A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102365159A (en) * | 2009-03-03 | 2012-02-29 | 英诺吉尔股份公司 | Starch-based soft capsule, and method and apparatus for the production thereof |
-
2002
- 2002-01-18 CN CN 02110580 patent/CN1432356A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102365159A (en) * | 2009-03-03 | 2012-02-29 | 英诺吉尔股份公司 | Starch-based soft capsule, and method and apparatus for the production thereof |
| CN102365159B (en) * | 2009-03-03 | 2015-07-01 | 英诺吉尔股份公司 | Starch-based soft capsule, and method and apparatus for the production thereof |
| US9486415B2 (en) | 2009-03-03 | 2016-11-08 | Innogel Ag | Starch foils and/or films and a method and use of a device for the production thereof |
| US11160760B2 (en) | 2009-03-03 | 2021-11-02 | Innogel Ag | Soft capsule based on starch and a method and device for the production thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| RU2093143C1 (en) | Medicinal form and a method of its preparing | |
| CN101370477A (en) | Film lined pouch and method of manufacturing this pouch | |
| CN104417918B (en) | A kind of packaging of lyophilized excipient preparation and delivery system and preparation method thereof | |
| CN103318551A (en) | System for packaging and delivering freeze-dried excipient and preparation method of freeze-dried excipient | |
| CN101849901A (en) | Technique for preparing controlled-release preparation of zero-order release bar and preparation thereof | |
| CN104920933A (en) | Propolis soft capsules and preparation method thereof | |
| CN102100894A (en) | Preparation technology of new integrative formulation of free wanderer powder and production method thereof | |
| RU2605271C1 (en) | Granules with extracts of cranberries, red bilberry madder antidiuretic, antispasmodic and litholytic action | |
| CN1432356A (en) | Prepn of biological regulating release capsule | |
| CN102000108A (en) | Gynaecological medicine composition as well as external-use capsule and application thereof | |
| CN203473563U (en) | Freeze-drying excipient packaging and delivering system | |
| CN102283928A (en) | Technology for preparing novel integrated dosage form of Ermiao powder and production method thereof | |
| CN102100888A (en) | Preparation technology and production method of new integrative formulation of major green-blue dragon decoction | |
| CN104800137B (en) | The applications of golden flower Flos Camelliae Japonicae extracts, preserving moisture and protecting skin composition and preparation method thereof | |
| CN1269206A (en) | Making process of Babu plaster for rheumatism and ostealiga | |
| CN102283944A (en) | Technology for preparing novel integrated dosage form of lung heat expelling powder and production method thereof | |
| CN106362141A (en) | Safe and multi-effect freckle removing agent and preparation method thereof | |
| CN208732031U (en) | A kind of double rubber plug delivery systems | |
| CN102283926A (en) | Preparation technology and production method for novel integrated dosage form of liver fire-purging and stomach-regulating pill | |
| CN101081227B (en) | Composition of diammonium glycyrrhizinate | |
| CN101066455B (en) | Medicine carrying aquogel matrix for preparing plaster and its preparation process | |
| CN102895334A (en) | Preparation technology and production method for integrated new formulation of licorice and monkshood decoction | |
| CN106881028A (en) | A kind of dissolver of new lyophilized formulations | |
| CN102284024A (en) | Preparation technology of integrated novel Weijing decoction dosage form | |
| CN1062465C (en) | Shuangwujiangtang capsule for reducing blood sugar |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |