CN1430500A - Skin care moisturizing and sunscreen compositions comprising organic particulate material - Google Patents

Abstract

The present invention relates to a topical cosmetic composition with an aqueous continuous phase, in the form of a lotion, cream or gel, comprising: i) from 0.01% to 25%, by weight, of an organic particulate material having a median particle size of from 0.5 to 30 mm; ii) greater than 8%, by weight, of a humectant selected from glycerine, polyalkylene glycol, urea, D or DL panthenol, hexane-1, 2, 6- triol, guanidine or its derivatives, alkylene glycols such as butylene glycol and propylene glycol, and mixtures thereof; iii) from 2% to 20%, by weight, organic sunscreen for providing highly efficacious levels of moisturisation and UV protection while maintaining optimum skin feel. Preferred embodiments are oil in water emulsions wherein the particulate material has been pre-dispersed within an organosiloxane oil to provide for desired non tacky skin feel.

Description

The skin care moisturizing and the sunscreen composition that contain organic particulate material

Invention field

The present invention relates to have the topical compositions that contains water continuous phase, this compositions is suitable for the wettability that height is provided in having the product that highly can accept the dermal sensation performance.More specifically say, the present invention relates to topical compositions, said composition also provides the adverse effect that is protected from ultraviolet radiation except that the wettability effect, keeps best dermal sensation simultaneously.Compositions of the present invention is effective especially to the skin on process facial and the hand, and is also very effective to other regional skin of health.

Background

For a long time, the characteristics of polytype topical compositions (comprising skin care compositions) be they contain have moistening, the composition of skin condition and UV protection beneficial effect.This compositions is used to improve the hydration levels of skin and the harmful and damage effect that protection skin is avoided ultraviolet radiation.In the environment of today, along with consumer touches the very exsiccant condition of skin that makes more and more, as air-conditioned building, and the UV irradiation becomes more harmful because of the destruction of ozone layer, people are growing to the demand of skin-protection product, and particularly face protects and repair the infringement that these daily harmful invasion and attack cause with product.

On the contrary, these skin benefit agents, particularly organic sunscreen agent and water solublity wetting agent and vitamin, its sensation in skin may be very sticking, the result causes the compositions that contains these compositions of significant quantity to have very unacceptable dermal sensation performance, comprises over-drastic greasy feeling, adhesion sense and drags the Ta sense when using.In addition, when these high-load wetting agents were combined with thickening agent, viscosity may increase.Thus, contain the said effective content that is used to give the composition of beneficial effect up to today at the preparation topical compositions, carry out compromise selection and will make simultaneously between the content minimum of these identical components, so that make final products have the acceptable dermal sensation of consumer.Yet for reaching acceptable dermal sensation performance, topical compositions often contains effective high viscosity composition of suboptimum content so far, and causing to reaching desirable skin beneficiating effect needs repeatedly to use for a long time.Owing to the composition of the adhering performance with extreme difference is normally water miscible, so this problem is especially serious in having the topical compositions that contains water continuous phase.This is because composition with high viscosity, when existing or being dissolved in when containing aqueous phase, uses the back with high concentration and contact skin.Therefore expectation provides a kind of topical compositions that contains water continuous phase that has, and the composition with skin beneficiating effect, particularly moistening and UV protection effect that it contains effective dose has the acceptable dermal sensation performance of consumer simultaneously.

So far, comprise granular material, comprise organic and inorganic particle, report in that skin care compositions is existing, so that influence the matter structure of skin and compositions itself.For example, referring to " quantitative analysis of soft focus effect (Quantification of the Soft-Focus Effect) ", Hua Zhuanpin ﹠amp; Toilet articles, Vol.111, in July, 1996, pp.57-61 wherein discloses and can use reflective substance such as TiO ₂Physical property is filled the skin streakline.US-A-4,892,726 (Toshiba Solicone Co.Ltd) have described the purposes of poly methyl silsesquioxane powder in cosmetic and cosmetic composition, and this compositions is slick when using and gives natural colour.These granules now can be from Toshiba Solicone Co.Ltd with various grain graininess ranks Tospearl by name ^Obtain.WO 00/24372 has described topical compositions, this compositions contain 0.5wt% to 25% refractive index be 1.35 to 1.6 and grain graininess be the granular material of 2 to 30 μ m, improve activating agent such as vitamin b 3 compound and retinoid coupling with other outward appearance, be used for providing visible improvement to skin.Wherein disclosed granule comprises Tospearl equally ^145A, its median particle is about 4.5 μ m.Similarly, examine application PCT/US99/04748 jointly and disclose topical compositions, contain 0.1% to 10% granular organic material, also have 1.3 to 1.7 refractive index, this compositions is suitable for immediately the improvement basically that dermal sensation and outward appearance are provided.EP-A-692,242 to disclose granularity be the purposes that hollow, the deformable particle of 1 to 250 μ m, first-selected 18 μ m is used to reduce the adhesion sensation of the essentially no water composition that is rich in fatty material; EP-A-908,175 disclose stable cosmetic composition, and it contains at least a fatty phase, crosslinked elastic organic polyorganosiloxane and high-load organosiloxane granule; And EP-A-790,055 discloses partial cross-linked elasticity organic siloxane polymer combined with fat (it is interior mutually preferably to be encapsulated in fat) is used to prepare the purposes that the compositions of matt appearance is provided to skin.These applications disclose the various cosmetic compositions that improve dermal sensation and skin appearance performance that have.Yet these applications openly do not have the Aquo-composition of efficient content moistening and UV protection beneficial agent.

Prior art combinations and open source literature are providing useful progress aspect beauty treatment skin processing and organic granular and the skin benefit agents coupling.Yet they sufficiently do not instruct skin moisturizing and the UV protection composition how effective content is provided simultaneously in the topical compositions of aqueous base, and said topical composition also has the acceptable dermal sensation performance of consumer.

Beyond thought is to have been found that the high viscosity defective with the topical skin care compositions (moistening and the UV protection composition that also contain efficient content) that contains water continuous phase, can reduce by the organic granular that comprises one or more types with certain granules granularity and critical surface tension in compositions in addition.Importantly, the improvement of dermal sensation performance is so important, protects so that will reach the UV that wettability and organic method of height reach in a prescription.In the past, this combination was because its unacceptable viscosity was impossible.In addition, if find also that with the organic granular premixing improvement of the dermal sensation that is reached is bigger in low viscous organosiloxane oil.

Do not think bound by theoryly, it is believed that the friction when comprising granular material can reduce product and use.When product was used, granule itself was positioned at the residue/air interface place of product, is positioned on the product residue surface.Reduced the sensation that contacted and improve skin of skin thus with the product residue.For guaranteeing to make granule pass to skin surface in the application with effective and efficient manner, preferably with the granule premix in carrier oil.The complete suppressed by vector oil immersion of granule is wet and is low viscous, and therefore this high fluidity of pre-composition guarantees that granule spreads on the skin surface effectively when product is used.

An object of the present invention is to provide and have the topical compositions that contains water continuous phase, said composition is fit to give the wettability and the UV protectiveness of skin high level.Another object of the present invention provides the topical compositions that contains granular material such as poly methyl silsesquioxane, and its viscosity of offsetting preparation is so that transmit desirable dermal sensation performance.Another object of the present invention provides and can be used for need not repeatedly to use the wettability that just can transmit desirable degree and the compositions of UV protectiveness.

These and other objects of the present invention will become apparent by following description.

Summary of the invention

The present invention relates to be the part cosmetic composition that having of distillate medicinal water (lotion), cream or gel form contains water continuous phase, said composition contains:

I) 0.01wt% to 25wt% median particle size is the granular organic material of 0.5 to 30 μ m;

Ii) greater than the 8wt% wetting agent, be selected from glycerol, poly alkylene glycol, carbamide, D or DL pantothenylol, oneself-1,2,6-triol, guanidine or derivatives thereof, aklylene glycol such as butanediol and propylene glycol with and composition thereof;

Iii) 2wt% to 20wt% organic sunscreen agent.

Moistening and UV protection that this compositions can be used for giving efficient degree keep acceptable dermal sensation performance simultaneously.

The invention still further relates to the manufacture method that strengthens the dermal sensation beneficial agent and give the beauty method of wettability and UV protectiveness by the local application present composition. Detailed Description Of The Invention

Unless indication is arranged in addition, employed all percentage ratios of this paper and ratio all are based on total composition weight meter, and all measurements all carry out under 25 ℃.Except as otherwise noted, all percentage ratios, ratio and the content of the composition that this paper is related all is based on the actual amount of composition, be not included in the commercially available acquisition product may with solvent, filler or other material of said composition combination.

Except as otherwise noted, the equal integral body of all publications that this paper quoted is incorporated herein by reference.

Herein, term " acceptable on the skin " means compositions or its component and is fit to be used for not have undue toxicity, incompatibility, unstability, anaphylaxis or the like with people's contact skin.

Herein, term " safe and effective amount " means chemical compound, component or compositions is enough to obviously cause that the front beneficial effect is (preferred, the front beneficial effect of skin appearance or sensation comprises beneficial effect disclosed herein independently) but enough low to the amount that serious side effects (promptly providing reasonably within medical judgment scope reliably and be benefited/risk ratio) can be provided.

Herein, useful active component and other composition are classified or are described by their beauty treatment and/or treatment beneficial effect or their required model of action.Yet should be understood that: can be used for the active substance of this paper and other composition can provide more than one beauty treatment and/or treatment beneficial effect in some cases or prove effective via more than one model of action.Therefore, it is for simplicity that this paper classifies, and application of not planning that composition is limited to and being specified or listed application.

To describe the element of these compositionss below in detail. The necessary element of compositions The granular organic material

Compositions contains has an appointment 0.01% to about 25%, preferred about 0.1% to about organic granular of 15%, more preferably from about 0.2% to about 5%.The median particle that it is most preferred that organic granular is about 0.5 to about 30 μ m, and preferred about 0.5 to about 15 μ m, and more preferably from about 0.7 to about 10 μ m, and more preferably from about 1 to about 7.5 μ m.Median particle is meant the granular material of the powder shape that is clean form (promptly pure basically form).Yet the concrete measuring method of grain graininess requires granular material is dispersed in inert carrier such as the pure oil, so that measure the distribution of grain graininess.Median particle can be measured by any suitable method known in the art, for example by using coulter counter (Coulter counter) or ASTM name E20-85 " by the grain graininess analytical standard method (StandardPractice for Particle Size Analysis of Particulate Substancesin the Range of 0.2 to 75 Micrometers by Optical Microscopy) of light microscope determining 0.2-75 micrometer range particulate matter ", ASTM Volume 14.02,1993.Preferably, surpass 50%, preferably surpass 60%, more preferably surpass 70% granule and belong in the particle size range of corresponding median defined.

Preferred granule is free-pouring solid material.Mention " solid ", be meant that granule is preferably stiff and indeformable.Granule is selected from organic siloxane polymer, polyethylene, polyacrylonitrile, polyacrylic acid or derivatives thereof, polymethylacrylic acid, polystyrene, polytetrafluoroethylene (PTFE), poly-(vinylidene chloride), polyamide and composition thereof.More preferably the granular organic material is selected from organic siloxane polymer and composition thereof, and is more preferably poly methyl silsesquioxane.Also can use the monomeric copolymer that derives from aforementioned material.The example of the poly methyl silsesquioxane granular organic material of suitable commercially available acquisition is Tospearl ^145 (its median particle is about 4.5 μ m) and Tospearl ^1320 (its median particle is 12 μ m).The example of other representational commercially available acquisition is the Fluoropure 100C that Shamrock Inc produces, and it is a politef granular organic material.

The example of another kind of representational commercially available acquisition is the EA-209 that Kobo produces ^, it is that median particle is the ethylene/acrylic acid copolymer of about 10 μ m.

The granular organic material preferably has the critical surface tension less than 50mN/m, preferably less than 40mN/m and be more preferably less than 35mN/m." critical surface tension " gets Drew and Myers at " surface, interface and colloid; principle and application (Surfaces; Interfaces andColloids; Principles and Applications) " 1991 Ch17, pp364-369, implication of definition and measuring by a series of contact angle measurements with the tensile relevant liquid of different surfaces beyond doubt in (VCH Publishers Inc, New York), this assay method also has outline in aforesaid list of references. Wetting agent

Contain in the compositions of the present invention have an appointment 8% to about 30%, preferred about 8.5% to about 20% and 9% to about 15wt% wetting agent more preferably from about.Preferred wetting agent include, but is not limited to be selected from glycerol, polyether polyols, carbamide, D or DL pantothenylol, oneself-1,2,6, the chemical compound of-triol, guanidine or derivatives thereof, aklylene glycol such as butanediol or propylene glycol.Wetting agent very preferably is glycerol, carbamide and composition thereof.Above-claimed cpd can be introduced separately into or make up introducing.Aforesaid chemical compound can produce the viscosity of high level, particularly when when using greater than 8% preferred amounts.Yet, have been found that this stickiness feeling can offset effectively by being used in combination wetting agent and organic granular, as described herein. The organic sunscreen agent

Contain the organic sunscreen agent in the compositions of the present invention.Suitable sunscreen can have UVA absorbent properties, UVB absorbent properties or its mixed performance.Definitely measuring of sunscreen actives agent is that " SPF " of compositions and the UVA of required degree protect and difference in required sun protection factor certainly.

The present composition preferably contains at least 10, preferred at least 15 SPF.(SPF is the index that typical sunscreens prevents the light protection of erythema.SPF is defined as the ratio that produces the needed ultraviolet energy of same minimum erythema on the needed ultraviolet energy of minimum erythema and the not protection skin in same individual producing on the protected skin.Referring to See Federal Register, 43, No166, pp.38206-38269, on August 2nd, 1978).Contain in the compositions of the present invention and have an appointment 2% to about 20%, more typical about 4% to about 14wt% organic sunscreen agent.Suitable sunscreen includes, but is not limited to, " those sunscreen of putting down in writing in international cosmetic composition dictionary of CTFA and the handbook, the 7th edition, the 2nd volume, pp.1672, Wenninger and McEwen compile (cosmetics, toilet articles and fragrance association, Inc., Washington, D.C., 1997).

Preferably contain UVA in the present composition and absorb the sunscreen actives agent, its absorbing wavelength is the UV ray of about 320nm to about 400nm.Suitable UVA absorbs the sunscreen actives agent and is selected from dibenzoylmethane derivative, o-aminobenzoa derivant such as methyl 2-aminobenzoate and high menthyl ester of 1-N-acetyl group ortho-aminobenzoic acid (homomethyl) and composition thereof.The example of dibenzoyl methane sunscreen actives agent is in US patent 4,387,089 (Depolo) and " sunscreen: exploitation, evaluation and adjustment aspect (Sunscreens:Development, Evaluation, andRegulatory Aspects) " (N.J.Lowe and N.A.Shaath compile, Marcel Dekker, Inc (1990)) describes to some extent in.The amount that UVA absorbs the sunscreen actives agent preferably can be independently or with compositions in other UV protection activating agent combination that may exist wide spectrum UVA is provided protection.

The agent of preferred UVA sunscreen actives is agent of dibenzoyl methane sunscreen actives and their derivant.They include, but is not limited to be selected from 2-methyldiphenyl formyl methane, 4-methyldiphenyl formyl methane, 4-isopropyl diphenyl formyl methane, 4-tert-butyl group dibenzoyl methane, 2,4-dimethyl dibenzoyl methane, 2,5-dimethyl dibenzoyl methane, 4,4 '-diisopropyl benzoyl methane, 4-(1, the 1-dimethyl ethyl)-4 '-methoxy dibenzoyl methane, 2-methyl-5-isopropyl-4 '-methoxy dibenzoyl methane, the 2-methyl 5-tert-butyl group-4 '-methoxyl group-dibenzoyl methane, 2,4-dimethyl-4 '-methoxy dibenzoyl methane, 2, the material of 6-dimethyl-the 4 '-tert-butyl group-4 '-methoxy dibenzoyl methane and composition thereof.Preferred dibenzoyl sunscreen actives agent comprises and is selected from 4-(1, the 1-dimethyl ethyl)-4 '-methoxy dibenzoyl methane, the material of 4-isopropyl diphenyl formyl methane and composition thereof.Preferred sunscreen actives agent is 4-(1, the 1-dimethyl ethyl)-4 '-methoxy dibenzoyl methane.

Sunscreen actives agent 4-(1, the 1-dimethyl ethyl)-4 '-methoxy dibenzoyl methane, be also referred to as butyl methoxydibenzoylmethise or Avobenzone, can be from GivaudanRoure (Internat ional) S.A. (Basel, Switzerland) by trade name Parsol ^1789 and from Merck ﹠amp; Co., (Whitehouse Station is NJ) by trade name Eusolex for Inc ^9020 is commercially available.Sunscreen 4-isopropyl diphenyl formyl methane is also referred to as isopropyl diphenyl formyl methane, can be from Merck by trade name Eusolex ^8020 is commercially available.

Compositions of the present invention preferably also contains the agent of UVB sunscreen actives, and its absorbing wavelength is the UV ray of about 290nm to about 320nm.Contain in the compositions can be independently or with compositions in other UV protection activating agent combination that may exist the UVB sunscreen actives agent of the safe and effective amount of UVB protection is provided.Compositions preferably contain have an appointment 0.1% to about 16wt%, more preferably from about 0.1% to about 12wt%, first-selected about UVB of 0.5% to about 8wt% absorbs organic sunscreen.

The agent of various UVB sunscreen actives all is suitable for the present invention.The non-limiting example of this organic sunscreen actives is described in US patent 5,087,372 (1992.1.11 authorizes Haffey etc.) and US patent 5,073,371 and 5,073,372 (all authorizing Turner etc. in 1991.12.17).The agent of preferred UVB sunscreen actives is selected from 2-cyano group-3,3-diphenylacrylate-2-Octyl Nitrite (being called octocrylene), 2-phenyl-benzimidazole-5-sulfonic acid (PBSA), cinnamate and their derivant such as p-methoxycinnamic acid 2-Octyl Nitrite and p-methoxycinnamic acid monooctyl ester, the TEA salicylate, octyldimethyl PABA, camphor derivatives and their derivant and composition thereof.Preferred organic sunscreen actives is a 2-cyano group-3,3-diphenylacrylate-2-Octyl Nitrite (being called octocrylene), 2-phenyl-benzimidazole-5-sulfonic acid (PBSA), octyl group-p-methoxycinnamic acid ester and composition thereof.Also can use in the salt of acid sunscreen and the acid and form.When using organic sunscreen agent salt such as PBSA in the compositions of the present invention, they can disturb the effect of thickening agent, and the result makes final products can have the rheological characteristic of suboptimum.This can offset by adding more high-load thickening agent, aliphatic alcohol or non-ionic surface active agent, so that the rheological characteristic of final products returns to desirable degree.

Any compositions that can also use in the present invention is added and is used for stablize the reagent of UVA sunscreen, so that light degradation and keep its UVA to protect effect thus when preventing that it from contacting with the UV ray.Mentioned a lot and should select those can simultaneously compatible with compositions as a whole chemical compound as the chemical compound that these stabilities can be provided with the UVA sunscreen.Suitable stabilizing agent comprises (but being not limited to), US patent 5,972,316; 5,968,485; 5,935,556; 5,827,508 and patent WO 00/06110 in the stabilizing agent described.The preferred stabilizing agent example that is fit to the present invention's use comprises 2-cyano group-3,3-diphenylacrylate-2-Octyl Nitrite (being called benzonitrile acrylic acid-monooctyl ester), 2-cyano group-3, the 3-diphenyl-ethyl acrylate, 3,3-diphenylacrylate 2-Octyl Nitrite, 3, two (4-methoxyphenyl) ethyl acrylate of 3-and composition thereof.First-selected 2-ethylhexyl-2-cyano group-3,3-diphenylacrylate ester.

Any compositions that can also use in the present invention is added and is used for improving the affinity of these compositionss on skin, particularly strengthens their water-fast reagent of washing off or wiping.The preferred reagent that this beneficial effect can be provided is ethylene and acrylic acid copolymer.The compositions that contains this copolymer is disclosed in the US patent 4,663,157 (Brock, 1987.5.5 authorizes). All the other elements of compositions

Compositions as herein described is aqueous, emulsion oil-in-water preferably, and can contain multiple other nonessential component, said these nonessential components are suitable for and make these compositionss is that beauty treatment is last, aesthetic or others are more acceptable or their additional use benefits are provided, precondition be these nonessential components with solvent described herein and preparation method physically and chemically compatible, and can too not weaken the stability relevant, effect or other purposes benefit with the present composition.Nonessential component dispersion, dissolving or similar fashion are present in the carrier of this compositions.

The nonessential composition of these routines is well known to a person skilled in the art.They include, but is not limited to emollient, oil absorber, antimicrobial, binding agent, buffer agent, denaturant, the beauty treatment astringent, outside analgesics, film former, wetting agent, opacifying agent, spice, pigment, skin is releived and consolidant, antiseptic, propellant, the percutaneous permeability reinforcing agent, solvent, suspending agent, emulsifying agent, cleaning agent, thickening agent, solubilizing agent, wax, inorganic sunscreen, non-Exposure to Sunlight type suntan, antioxidant and/or free radical scavenger, chelating agen, anti-acne agents, antiinflammatory, desquamation agent/keratodermatitis remover, organic hydroxy acid, vitamin, natural extract and inorganic particle such as silicon dioxide and boron nitride.The nonexcludability case description of these materials in Harry Family name's conduct and learning of making up, the 7th edition, Harry and Wilkinson (Hill Publishers, London, 1982); Pharmaceutical dosage form-disperse systemLieberman, Rieger and Banker, the 1st volume (1988) and the 2nd volume (1989), Marcel Decker company limited; The chemistry of cosmetics And manufacturing, the 2nd edition, deNavarre (yan Nostrand 962-1965) and Cosmetics section Learn and technical manual, the 1st edition, Knowlton and Pearce (Elsevier1993).They also can be used for the present invention.

Preferred compositions has about 5,000 to about 200, the apparent viscosity of 000mPa.s (centipoise).For example, preferred distillate medicinal water has about 10,000 to about 40, the apparent viscosity of 000mPa.s; Preferred cream ointment has about 30,000 to about 160, the apparent viscosity of 000mPa.s.Apparent viscosity can be by using Brookfield DVll RV viscometer, and rotating shaft TD measures under 5rpm, or uses its equivalent way to measure.(usually, under 25 ℃ and ambient pressure, stablized at least 24 hours after the preparation compositions) after the composition stable for the treatment of to have prepared, compositions is carried out viscosimetric analysis.Under 25 ℃, after 30 seconds, compositions is carried out viscosimetric analysis in the rotating shaft rotation.

As a rule, it is 9.5 or lower that compositions of the present invention is mixed with pH, and common pH scope is about 4.5 to about 9, more preferably from about 5 to about 8.5.Some compositions particularly contains additional activity material such as salicylic compositions, requires lower pH so that the additional activity material can come into force fully.Usually, these compositionss are mixed with pH about 2.5 to about 5, more preferably from about 2.7 to about 4. Carrier

Compositions of the present invention preferably contains being fit to acceptable carrier on the skin of topical application of safe and effective amount, the material of necessity and other nonessential material are introduced in this carrier, necessary material and nonessential component can be delivered on the skin with suitable concentration.Therefore carrier can serve as the diluent that is used for any active substance, dispersant, solvent or the like, guarantees that they can be applied to equably or be dispersed on the selected target with suitable concentration.

Contain water continuous phase in the compositions of the present invention and preferably contain emulsion oil-in-water, wherein hydrophobic phase, for example, lipid, oil or oily material are dispersed in and contain aqueous phase.In emulsion technology, term " decentralized photo " is to well known to a person skilled in the art term, and the form that means with small particle or droplet exists, and it is suspended in the continuous phase and is surrounded by continuous phase.Decentralized photo is also referred to as inside or discontinuous phase.Generally contain 1% dispersive hydrophobic phase and about 1% the successive aqueous favoring of having an appointment in the emulsion oil-in-water to about 99% (preferred about 40% to about 90%) to about 50% (preferred about 1% to about 30%).Also can comprise the gel net in the emulsion, as G.M.Eccleston, " application (Application of Emulsion Stability Theories to Mobile andSemisolid O/W Emulsions) of stability of emulsion theory in mobile and semi-solid O/W emulsion ", " cosmetics and toilet articles (Cosmetics ﹠amp; Toiletries) ", the 101st volume, described in the 73-92 page or leaf, is introduced into this paper as a reference in November, 1996.

Carrier very preferably is liquid or semisolid, as cream, distillate medicinal water and gel.Preferred vector is the form with cream dew, distillate medicinal water or gel, has enough denseness or yield point to prevent particulate deposition.Carrier itself can be inert, and perhaps himself can have the benefit on the Dermatology.Carrier also should be physically and chemically with necessary component compatibility as herein described, and should not weaken the stability relevant, effect inadequately or other uses benefit with the present composition.

The type of used carrier depends on the type of the product form that compositions is required among the present invention.Topical compositions of the present invention can be made various product forms known in the art.These forms comprise (but being not limited thereto) distillate medicinal water, cream, gel, bar-shaped, spray, ointment, paste and mousse.These product forms can contain the carrier of a few types, include, but is not limited to solution, aerosol, emulsion, gel, solid and liposome.

Preferred carrier contains acceptable hydrophilic diluents on the skin.Suitable hydrophilic diluents comprises water, organic hydrophilicity diluent such as C ₁-C ₄Monohydric alcohol and low molecular weight diol and polyhydric alcohol, (for example comprise propylene glycol, Polyethylene Glycol, molecular weight is 200-600), polypropylene glycol (for example, molecular weight is 425-2025), glycerol, butanediol, 1,2,4-butantriol, sorbitol ester, oneself-1,2,6-triol, ethanol, isopropyl alcohol, ethoxylated ether, propoxylated ether and combination thereof.Diluent is liquid preferably.Water is particularly preferred diluent.Compositions preferably comprises the hydrophilic diluents at least about 60%. Emollient

Usually contain in the topical compositions of the present invention have an appointment 1% to about 50%, preferred about 1.5% to about 15% skin acceptable emollient.Emollient is tending towards lubricated skin, increases skin smoothness and flexibility, prevents or extenuate xerosis cutis and/or protection skin.Emollient in general be with water can not be miscible oiliness or wax material, and have high-molecular weight emollient and can bring being clamminess property to topical compositions.Known have various suitable emollient and can be used for the present invention.Sagarin, " Cosmetic science and technology (Cosmetics, Science and Technology)" the 2nd edition, Vol.1, pp.32-43 has introduced the material that a lot of examples are suitable as emollient in (1972).All emollient of discussing among the application WO00/24372 are considered to be suitable for the present invention, below preferred examples is further provided in detail: i) have about 7 straight chain and branched-chain hydrocarbons to about 40 carbon atoms, for example dodecane, squalane, cholesterol, Parleam, 2-Methylpentadecane, and C ₇-C ₄₀Isoparaffin, it is C ₇-C ₄₀Branched-chain hydrocarbons.Ii) C ₁-C ₃₀Carboxylic acid and C ₂-C ₃₀The C of dicarboxylic acids ₁-C ₃₀Alcohol ester, for example isononyl isononanoate, isopropyl myristate, propanoic acid myristin, isopropyl stearate, isostearic acid isopropyl ester, isostearic acid methyl ester, behenic acid docosane ester, di-2-ethylhexyl maleate, diisopropyl adipate and dilinoleic acid diisopropyl ester.The iii) sugar and the C of related substances ₁-C ₆₀One ester or polyester.These esters are made of sugar or polyol moiety and one or more carboxylic moiety.Depend on component acid and sugared, these esters at room temperature can be the liquid or solid forms.The example comprises: glucose four oleates, oleic galactose four esters, sorbitol four oleates, sucrose four oleates, sucrose five oleates, sucrose six oleates, sucrose seven oleates, sucrose eight oleates, wherein carboxylate moiety is that sorbitol six esters of 1: 2 mol ratio palm acid ester and Arachidate and the carboxylic moiety that wherein is used for esterification are the sucrose octaesters of 1: 3: 4 mol ratio laurate, linoleate and docosane acid group.Other material comprises the Oleum Gossypii semen or the soya fatty acid ester of sucrose.The visible WO96/16636 of other example of this material is introduced into this paper as a reference.A kind of particularly preferred material is the poly-Oleum Gossypii semen acid esters of sucrose that is known as the INCI title.Iv) vegetable oil and hydrogenated vegetable oil.The example of vegetable oil and hydrogenated vegetable oil comprises the partially or completely hydrogenated oil and fat and composition thereof in safflower oil, Oleum Ricini, Oleum Cocois, Oleum Gossypii semen, pilchardine, palm-kernel oil, Petiolus Trachycarpi oil, Oleum Arachidis hypogaeae semen, soybean oil, rapeseed oil, Semen Lini oil, Testa oryzae oil, Oleum Pini, Oleum sesami, sunflower seed oil, aforementioned source. Emulsifier/surfactant

Compositions of the present invention preferably contains emulsifying agent and/or surfactant, helps to make discontinuous phase to disperse and be suspended in continuously to contain within the water.As fruit product is to desire to be used for skin clean, and then surfactant also is useful.Below for simplicity, this paper belongs to emulsifying agent in the scope of term " surfactant ", and " surfactant " is used to refer to or as the emulsifying agent effect or be used for the surface-active agents of other surfactant purposes such as skin clean thus.Can use known or conventional surfactant in the compositions, precondition is selected reagent chemically and physically is compatible with the necessary component of compositions, and required characteristic is provided.Suitable surfactant comprises material and its mixture that derives from non--polysiloxanes.The all surface activating agent of discussing among the application WO00/24372 should be considered to be applicable to the present invention.

Compositions of the present invention preferably contains have an appointment 0.05% to about 15% surfactant or surfactant mixture.Select definite surfactant or surfactant mixture according to the pH value of compositions and other component of existence.

Preferred hydrophilic surfactant is a nonionic.Can be used for non-ionic surface active agent of the present invention is those non-ionic surface active agents that can be defined as the condensation product of long-chain alcohol (as C8-30 alcohol) and sugar or starch polymer (being glucosides) widely.Other useful ionic surfactant pack is drawn together the condensation product (being the alkylene oxide ester of fatty acid) of alkylene oxide and fatty acid.These materials have general formula R CO (X) nOH, and wherein R is C _10-30Alkyl, X are-OCH ₂CH ₂-(promptly deriving from ethylene glycol or oxirane) or-OCH ₂CHCH ₃-(promptly deriving from propylene glycol or expoxy propane), n is about 6 to about 200 integer.Other non-ionic surface active agent is the condensation product (being the alkylene oxide diester of fatty acid) of alkylene oxide and 2 moles of fatty acids.These materials have general formula R CO (X) nOOCR, and wherein R is C _10-30Alkyl, X are-OCH ₂CH ₂-(promptly deriving from ethylene glycol or oxirane) or-OCH ₂CHCH ₃-(promptly deriving from propylene glycol or expoxy propane), and n is about 6 to about 100 integer.Other suitable example comprises the mixture of cetearyl alcohol, cetearyl glucoside, as pressing trade name Montanov68 and can press trade name Emulgade PL68/50 from Cognis UK Ltd. commercially available from Seppic.The example of the suitable cetearyl glucoside material that does not add aliphatic alcohol is Tego (RTM) Care CG90, and commercially available acquisition is from Goldschmidt GmbH.

Can be used for hydrophilic surfactant active of the present invention can be in addition or additionally comprise in various cation known in the art, anion, amphion and the amphoteric surfactant any.Referring to for example McCutcheon, Detergent and emulsifying agent(Detergents andEmulsifiers), North America version (1986), open by Allured publishing company; US patent 5,011,681 (1991.4.30 authorizes Ciotti etc.); US patent 4,421,769 (1983.12.20 authorizes Dixon etc.) and US patent 3,755,560 (1973.8.28 authorizes Dickert etc.).Multiple anion surfactant also can be used for the present invention.Referring to, for example the US patent 3,929,678 (1975.12.30 authorizes Laughlin etc.).

Multiple anion surfactant also can be used for the present invention.Referring to, for example the US patent 3,929,678 (1975.12.30 authorizes Laughlin etc.).The non-limiting example of representational anion surfactant comprises the soap (for example alkali metal salt, for example sodium salt or potassium salt) of alkanoyl isethionic acid ester (for example C12-C30), alkyl and alkyl ether sulphate and salt, alkyl and alkyl ether phosphate and salt, taurine alkyl methacrylate ester (for example C12-C30) and fatty acid.

Both sexes and zwitterionic surfactant also can use in the present invention.Can be used for the both sexes of the present composition and the example of zwitterionic surfactant is those surfactants that extensively are described as the derivant of the aliphatic series second month in a season and tertiary amine, wherein aliphatic group can be straight chain or side chain, and one of them aliphatic substituent group contains to have an appointment and 8 contains the anionic water solubilization radical to about 22 carbon atoms (being preferably C8-C18) and one, for example carboxyl, sulfonate radical, sulfate radical, phosphate radical or phosphonate radical.Example is alkyl imino acetate, iminodiacetic alkanoate and amino-alkane hydrochlorate, imidazoline drone salt and ammonium derivative.Both sexes that other is suitable and two ionic surface active agents are selected from betanin, sulfobetaines, hydroxyl sulfo betaine, branch or unbranched and alkanoyl sarcosinate and composition thereof. Thickening agent (comprising thickening agent and gellant)

Compositions of the present invention more preferably contains thickening agent, and more preferably from about 0.1% to about 5%, and more preferably from about 0.1% to about 3%, and first-selected about 0.25% to about 2% thickening agent.

Contain in the preferred compositions of the present invention and be selected from following thickening agent: carboxylic acid polyalcohol, Acusol772 Acusol771, polyacrylamide, xanthan gum and composition thereof more preferably are selected from polyacrylamide polymers, xanthan gum and composition thereof.With preferred polyacrylamide be pre-dispersed in can not with the miscible solvent of water in as the mineral wet goods, contain the surfactant (HLB about 7 to about 10) that helps lend some impetus to waterborne polyacrylamide in the said solvent.First-selection is used for the non-ionic polymers of the CTFA of being called after polyacrylamide of the present invention and isoparaffin and lauryl ether-7, and they can press the trade name acquisition of Sepigel 305 from Seppic company.Acrylic acid/the ethyl acrylate copolymer and the CVP Carbopol ETD2050 that also have B.F.Goodrich Company to sell with trade name Carbopol resin.Suitable Carbopol resin is seen W098/22085.All thickening agents of discussing among the application WO 00/24372 should be considered to be applicable to the present invention. Inorganic sunscreen

Except that the organic sunscreen agent, compositions of the present invention can also contain organic/inorganic substance reason sunscreen in addition.The non-limiting example of proper physical sunscreen is described in " the international cosmetic composition dictionary of CTFA " the 6th edition, 1995, pp.1026-28 and 1103, Sayre, R.M. etc., " physical sunscreen agent ", J.Soc.Cosmet.Chem., vol 41, and no2 is among the pp.103-109 (1990).Preferred inorganic physics sunscreen is zinc oxide and titanium dioxide and composition thereof.

When using, it is transparent (being non-brightening) on skin that the amount of physical sunscreen agent should make this compositions, preferably is less than or equal to about 5%.When using titanium dioxide, it can have anatase, rutile or impalpable structure.Physical sunscreen agent granule, as titanium dioxide and zinc oxide, can be uncoated or be coated with various materials, include, but is not limited to aminoacid, aluminium compound such as aluminium oxide, aluminium stearate, Aluminum trilaurate or the like; Carboxylic acid and their salt such as stearic acid and salt thereof; Phospholipid such as lecithin; Organosilicone compounds; Inorganic silicon siloxane compound such as silicon dioxide and silicate with and composition thereof.Preferred titanium dioxide be can be from Tayca (Japan) commercially available and by Tri-K Industries (Emerson, NJ) with MT little-ionizing series (as MT IOOSAS) distribution.

Preferably contain the 0.1wt% that has an appointment in the present composition to about 10wt%, more preferably from about 0.1wt% is to about 4wt%, the about 0.5wt% of the first-selection inorganic sunscreen of about 2.5wt% extremely. The activating agent that is used for the conditioning skin situation

The activating agent that is used for the conditioning skin situation that not necessarily contains safe and effective amount in the compositions of the present invention comprises preventative and therapeutic conditioning skin situation.Preventative conditioning skin situation comprises delay, reduces and/or prevents visible and/or tactile discontinuity in the skin.Therapeutic conditioning skin situation comprises that improvement for example eliminates, reduces and/or erase this discontinuity.The conditioning skin situation also relates to improves skin appearance and/or sensation.Also comprise the aged signal of conditioning, this conditioning comprises that preventative conditioning and/or therapeutic nurse one's health one or more signals such as microgroove, wrinkle, aperture etc.

The known composition that can be used for the conditioning skin situation is selected from vitamin b 3 compound, class xanthoplane and combination thereof.Described during as the description wetting agent, aforesaid chemical compound can produce the viscosity of high level when itself using separately, particularly when using with high level.Yet, it is found that the granule of the application of the invention can be offset this sexy feel of being clamminess.Compositions of the present invention preferably contains has an appointment 0.1% to about 15%, more preferably from about 0.3% to about activating agent of 10%, more preferably from about 1 to about 5%.

Herein, " vitamin b 3 compound " is meant the chemical compound with following formula: Wherein R is-CONH ₂(being nicotiamide) ,-COOH (being nicotinic acid) or-CH ₂OH (being nicotinyl alcohol); The salt of its derivant and any aforementioned substances.Can use one or more vitamin b 3 compounds or its salt or its mixture among the present invention.In a preferred embodiment, vitamin b 3 compound generally contains the chemical compound that is lower than about 50% salt form.Herein, " retinoid " comprises vitamin A or have chemical compound and the geometric isomer of these chemical compounds and all natural and/or synthetic analogues of stereoisomer of the bioactive similar retinol of vitamin A in skin.Equally, all skin conditions of discussing among the application WO 00/24372 should be considered to be applicable to the present invention with material. Antiinflammatory

Can add the antiinflammatory of safe and effective amount in the compositions of the present invention, be preferably about 0.1% to about 10%, more preferably about 0.1% to about 2% of compositions.Antiinflammatory can improve skin appearance benefits of the present invention, and for example, this medicament helps more all even acceptable skin color or color.Definitely the measuring of antiinflammatory that is used for compositions certainly in used concrete antiinflammatory, because this medicament alters a great deal aspect effectiveness.

Can be used for antiinflammatory of the present invention and comprise the steroid antiinflammatory, as hydrocortisone; Nonsteroidal anti-inflammatory (NSAIDS) is as ibuprofen; Pantothenylol and ether thereof and ester derivant are as panthenol ether, pantoyl base triacetate; Pantothenic acid and salt thereof and ester derivant, especially calcium pantothenate; The chemical compound of Aloe vulgaris, bisabolol, allantoin and Radix Glycyrrhizae class (Glycyrrhiza/kind of plant) comprises glycyrrhetinic acid, glycyrrhizic acid and derivant thereof such as salt (for example ammonium glycyrrhizinate) and ester (stearyl glycyrrhetinate).The preferred especially pantothenylol of the present invention, pantothenic acid and ether, ester or salt derivative with and composition thereof; Suitable content is about 0.1 to about 5%, preferred about 0.5 to about 3%.Pantothenylol is especially preferred. Antioxidant/free radical scavenger

Can also contain antioxidant/free radical scavenger in the compositions of the present invention.To be protected from UV radiation (it can cause cuticular decortication increase or matter structure to change) and to avoid causing other environmental agent of skin damage be useful especially to antioxidant/free radical scavenger to providing.Suitable amount is about 0.1% to about 10%, more preferably about 1% to about 5% of a compositions. Antioxidant/free radical scavenger

Operable antioxidant/free radical scavenger for example is ascorbic acid (vitamin C) and salt thereof, the acid ascorbyl ester of fatty acid, ascorbic acid derivates (for example magnesium ascorbyl phosphate), beta-carotene, tocopherol (vitamin E), tocopherol sorbic acid ester, tocopherol acetas, other ester of tocopherol, butylation hydroxy benzoic acid and salt thereof, gallic acid and Arrcostab thereof be propyl gallate particularly, uric acid and salt thereof and Arrcostab, sorbic acid and salt thereof, amine (N for example, N-diethyl hydroxylamine, amino-guanidine), mercapto compound (for example sweet peptide of paddy peptide), Dihydroxyfumaric acid and salt thereof, bioflavonoids, lysine, methionine, proline, superoxide dismutase, silymarin, tea extract, Pericarpium Vitis viniferae/seed extract, melanocyte and Herba Rosmarini Officinalis extract.Preferred anti-oxidants/free radical scavenger is selected from other ester of tocopherol acetas, tocopherol sorbic acid ester and tocopherol, more preferably tocopherol acetas.Described during as the description wetting agent, aforesaid chemical compound can produce the viscosity of high level when itself using separately, particularly when using with high level.Yet, it is found that the granule of the application of the invention can be offset this sexy feel of being clamminess. Intercalating agent

Contain chelating agen to be protected from UV radiation (it causes excessively decortication or skin matter structure to change) and to avoid causing other environmental agent (it can cause skin lesion) of skin damage be useful especially to providing.Suitable amount be compositions 0.01% to about 1%, be more preferably about 0.05% to about 0.5%.Can be used for representative chelating agen of the present invention is disclosed chelating agen in the US patent 5,487,884, and it is incorporated herein by reference.The preferred chelating agen that is used for the present composition is ethylenediaminetetraacetic acid (EDTA), furil-dioxime and derivant thereof. Desquamation agent/keratodermatitis remover

Can add the desquamation agent of safe and effective amount in the compositions of the present invention, more preferably about 0.1% of compositions to about 10%, more preferably about 0.2% to about 5%, more preferably about 0.5% to about 4%.The desquamation agent can strengthen skin appearance benefits of the present invention.For example, the desquamation agent tends to improve the matter structure (for example slickness) of skin.Known in the art and be applicable to multiple desquamation agent of the present invention, comprise organic hydroxy acid, as salicylic acid, glycolic, lactic acid, 5-decoyl salicylic acid, Hydroxycaprylic acid, Hydroxycaprylic acid and lanolin fatty acid.A kind ofly be suitable for desquamation system of the present invention and contain sulfydryl (sulphydryl) chemical compound and zwitterionic surfactant and be described among the WO 96/01101, it is incorporated herein by reference.The desquamation system of the present invention that is suitable for another kind contains salicylic acid and zwitterionic surfactant and is described in WO 95/13048, and it is incorporated herein by reference.Salicylic acid is preferred. Skin lightening agent

Compositions of the present invention can also contain skin lightening agent.When using, compositions preferably contains has an appointment 0.1% to about 10%, more preferably from about 0.2% to about 5%, preferred about 0.5% to about 2% skin lightening agent also.Suitable skin lightening agent comprises material known in the art, comprises kojic acid, arbutin, ascorbic acid and derivant thereof, for example magnesium ascorbyl phosphate.The skin lightening agent that other suitable the present invention uses also comprises the skin lightening agent of describing among WO 95/34280 and the WO 95/23780, and the two is all from being incorporated herein by reference. The composition of polysiloxanes base material

The composition that preferably also contains the polysiloxanes base material in the present composition.Below preferred examples will be discussed: i) The emollient of polysiloxanes base material. organopolysiloxane oil can be used as the composition with emollient beneficial effect in compositions of the present invention.Suitable organopolysiloxane oil comprises the mixture of volatility, nonvolatile or volatility and non-volatile polysiloxanes." non-volatile " refers to be in a liquid state under environmental condition and have the polysiloxanes that is higher than about 100 ℃ flash-point (under an atmospheric pressure) herein.Herein, term " volatility " refers to that flash-point is lower than about 100 ℃ polysiloxane oil.Suitable organopolysiloxane can be selected from various polysiloxanes, contains wide volatility and range of viscosities.Preferred nonvolatile polysiloxanes.Suitable polysiloxanes is disclosed in US patent 5,069,897 (1991.12.3 mandate), and its integral body is incorporated herein by reference.Be preferred for organopolysiloxane of the present invention and be selected from polydimethylsiloxane that poly-alkylsiloxane, alkyl replace, dimethiconol, polyoxyethylene alkyl aryl radical siloxane and composition thereof.More preferably being used for of the present invention is poly-alkylsiloxane and annular dimethyl polysiloxane.Polydimethylsiloxane preferably in the poly-alkylsiloxane, for example SF96 that produces of the DC200 that produces of Dow Corning and GE Silicone.Ii) The emulsifying agent of polysiloxanes base material. preferred emulsion of the present invention contains the emulsifying agent or the surfactant of polysiloxanes.Wide variety of silicone emulsifiers can be used for the present invention.These silicone emulsifiers generally are organically-modified organopolysiloxanes, and those skilled in the art also are referred to as polysiloxane surfactant.Useful silicone emulsifiers comprises dimethicone copolyol.These materials are to be modified to become to comprise the polydimethylsiloxane of polyether lateral chain, the mixture of wherein said polyether lateral chain such as polyethylene oxide chain, poly(propylene oxide) chain, these chains and the polyether chain that contains the part that derives from oxirane and expoxy propane.Other example comprises alkyl-modified dimethicone copolyol, promptly contains the chemical compound of the vertical side chain of C2-C30.Other useful dimethicone copolyol comprises the material with the vertical pendant moiety of various cationes, anion, both sexes and amphion. Preparation of compositions

The present invention relates to have the cosmetic composition that contains water continuous phase, said composition contains organic granular, is higher than 8% wetting agent and organic sunscreen agent.Compositions is emulsion oil-in-water preferably.These compositionss can prepare according to technology commonly used in the cosmetics and as well known to those skilled in the art and that understand, and the material that the class patibhaga-nimitta distributes can add by any order.

Before preferably in adding the remainder of compositions to, with organic granular slowly and equably premix be incorporated in the carrier oil.Compare with granule is directly added in the compositions, can make organic granular can more effectively offset the being clamminess property of skin benefit agents like this.In case after pre-composition forms, preferably should immediately this pre-composition be added in the remainder of compositions to keep helpfulness.If the remainder of compositions is an emulsion, then preferably before adding pre-composition, prepare emulsion.Can avoid between emulsified phase destruction like this because of the contingent pre-composition of step of high shear. Premix composition

Preferably contain in the pre-composition have an appointment 5% to about 90%, preferred about 20% to about 80% and 40% to about 75wt% organic granular more preferably from about.Preferred its viscosity is less than 5000mPa.s, and preferably less than 2000mPa.s, said viscosity uses air bearing (airbearing) Haakerheostress RS75 viscometer to measure, and this viscometer uses C35/2Ti cone-plate and 0.105mm clearance distance.Viscosity under 31 ℃ (skin temperatures) at 20s ^-1Shear rate under measure.In addition, preferred premixes forms mutually discrete in the remainder of compositions and keeps stable therein, so that can see that clearly diameter is greater than the drop of 0.1 μ m when using the normalized optical microscope to observe with the 40x amplification.Yet, will be appreciated that depend on other composition in the compositions, after compositions formed, some other compositions may another moves mutually in opposite directions from one, thereby can prevent that pre-composition from keeping real discrete phase. Carrier oil

Preferably the surface tension that carrier oil had less than the surface tension of selected organic granular and viscosity less than about 350mPa.s, preferably less than about 100mPa.s and be more preferably less than about 75mPa.s.The carrier oil viscosity is also measured down at 31 ℃ (skin temperatures), and the mode during with the whole pre-composition of description is the same.

Carrier oil is the oil of organosiloxane base material preferably, is selected from non-volatile, volatile organosiloxane and composition thereof." non-volatile " refers to that polysiloxanes is in a liquid state and has and is higher than about 100 ℃ flash-point (under an atmospheric pressure) under environmental condition herein.Herein, term " volatility " refers to that flash-point is lower than about 100 ℃ polysiloxane oil.Suitable organopolysiloxane can be selected from wide variety of silicone, contains wide volatility and range of viscosities.Preferred nonvolatile poly-(siloxanes).Suitable silicone carrier oil is disclosed in US patent 5,069,897 (1991.12.3 mandate).Be preferred for organopolysiloxane of the present invention and be selected from polydimethylsiloxane that poly-alkylsiloxane, alkyl replace, dimethiconol, polyoxyethylene alkyl aryl radical siloxane and composition thereof.More preferably being used for of the present invention is poly-alkylsiloxane and annular dimethyl polysiloxane.Polydimethylsiloxane preferably in the poly-alkylsiloxane, for example SF96 that produces of the DC200 that produces of DowCorning and GE Silicone.

Embodiment

Following examples will further illustrate the embodiment preferred that belongs in the scope of the invention.These embodiment only provide and are not interpreted as limitation of the present invention for illustrational purpose, because the present invention can have many variation schemes under the prerequisite that does not deviate from essence of the present invention or scope.Except as otherwise noted, all the components is all recently expressed with the weight percent of active component. Phase I

Embodiment	I	?II	??III	?IV	?V	?VI
							?Parso1?HS 1	1.0	?1.00	??1.00	?-	?-	?1.00
?Parsol?1789 1	1.00	?1.50	??2.00	?2.00	?2.00	?1.00
							Octocrylene 2	1.00	?2.00	??1.50			?1.00
Ethylhexyl salicylate 3	2.50	?3.50	??4.50	?3.00		?2.50
							?Parsol?MCX 1	?-	??-	??-	?-	?5.00	?-
Stearyl alcohol	0.40	?0.40	??0.48	?0.80	?1.2	?0.40
							Spermol	1.00	?0.80	??0.72	?1.80	?0.80	?1.00
?Hydrofol?Acid	0.10	?0.10	??0.10	??0.10	?0.10	??0.10
							?Myrj59 4	0.10	?0.10	??0.10	??0.10	?0.10	??0.10
The isostearic acid isopropyl ester 5	0.75	?1.00	??1.00	??0.5	?2.00	??0.75
							?SEFA?Cottonate 6	1.50	?1.00	??1.80	??-	?-	??1.50
Ethylparaben	0.15	?0.15	??0.20	??0.20	?0.25	??0.15
							Propyl p-hydroxybenzoate	0.20	?0.20	??0.30	??0.25	?0.25	??0.20
Tocopherol acetas	0.25	?0.50	??0.75	??0.50	?-	??0.25
							2-Methylpentadecane	-	?4.00	??-	??0.50	?1.00
Vaseline	-	?-	??-	??1.20	?0.50

Phase II

Embodiment	I	?II	III	IV	?V	VI
							Deionized water	To 100	To 100	To 100	To 100	To 100	To 100
Glycerol	9.00	?12.00	?-	15.00	?-	?9.00
							Kobo?GWL75CAP 7	0.30	?0.25	?0.50	?0.50	?0.50	?0.30
Macrogol 200 8	1.00	?-	?-	?-	?10.00	?1.00
							Oneself-the 126-triol	?-	?0.50	?3.00	?-	?-	-
Carbamide	-		?10.00	?-	?-	-
							Montanov68 9	-	?0.50	?0.20	?0.50	?0.20	-
Emulgade?PL68/50 10	-	?-	?-	?-	?-	0.25
							The EDTA disodium	0.10	?0.10	?0.10	?0.10	?0.10	?0.10

Phase III

Embodiment	I	II	?III	?IV	?V	?VI
							?Fluoropure?100C 11	0.50	?-	??-	?-	?-
?Tospearl?145A 12	-	1.00	??-	?-	?1.00	?1.00
							?Tospearl?120A 12	-	?-	??-	?1.00	?-
?Orgasol?2002?EXD?N?COS 13	-	?-	?1.00	?-	?-
							?DC200?5cs 14	-	0.65	?1.50	?-	?-
?DC200?50cs 14	0.17	?-	?-	?0.50	?-
							?DC200?100cs 14	-	?-	?-	?2.50	?-
2-Methylpentadecane	0.15	?-	?0.50	?-	?-	?-

Supplementary element

Embodiment	I	?II	?III	?IV	?V	?VI
							Sepigel?305 9	1.50	?2.00	?3.00	?2.00	?3.00	?1.50
The sodium hydroxide piller	0.013	?0.013	?0.013	?0.013	?0.013	?0.013
							Benzyl alcohol	0.20	?0.25	?0.25	?0.25	?0.30	?0.20
D-panthenol	-	?0.50	?0.50	?-	?1.00	?-
							Nicotiamide	-	?3.00	?-	?2.00	?5.00
DC?Q2-1403 14	1.60	?2.00	?1.50	?2.00	?2.50	?1.60
							Dry?Flo 15	-	?-	?-	?-	?-	?2

1.Hoffmann-LA Roche, Inc. provides, 340Kingsland Street, and Nutley, NJ 07110-11992.BASF Aktiengesellschaft provides, and MEM/KU-D 205,67056Ludwigshafen, German 3.Haarmann﹠amp; Reimer Corporation provides, 70Diamond Road, P.O.Box175, Springfield, NJ07081-01754.PEG 100 stearates, ICI provides, PO Box 90, Wilton Centre, Middlesborough, Cleveland, England, TS6 8JE5.Scher Chemicals Inc provide Industrial West, Clifton, NJ070126. the C1-C30 monoesters of a sugar or polyester and one or more carboxylic moiety are as described herein, the preferably sucrose polyester, and wherein degree of esterification is 7-8, and wherein fatty acid part is C18 single and/or two-unsaturated acids and behenic acid, unsaturated acids: the mol ratio of behenic acid is 1: 7 to 3: 5, the more preferably octaester of sucrose, the fatty acid part of 7 behenic acids of wherein having an appointment in molecule and about 1 oleic acid part, for example, the sucrose ester of cottonseed oil fatty acid.7.Kobo Products Inc provides, 690 Montrose Ave, So Plainfield, NJ 070808.Union Carbide Corporation provide Danbury, Conn., USA9.Seppic provides, 75 Quai D ' Orsay, and Paris 10.Cognis UK Ltd provides., the 3rd layer, Eleanor House, 33/35 EleanorCross Road, Waltham Cross, EN8 7LE, UK11.Shamrock Teclmologies Inc. provides, Newark, NJ07114, USA12.GE Silicones provides, Plasticslaan 1/PO Box117,4600 AC Bergenop Zoom, Dutch 13.Elf Atochem provides, 4, cours Michelet, La Defense 10, Cedex42,92091, Paris 14.Dow Corning provides, Kings Court, 185 Kinds Rd, Reading, Berks, RG1 4EX15. starch ocentyl succinic aluminum, National Starch and Chemical Limited provide Braunston, Daventry, Northants., NN11 7KL, UK

Mild heat prepares phase I thus until forming homogeneous mixture by mixing oil soluble emulsifying agent, emollient and oil-solvent preservative simultaneously.

By with water, glycerol, Kobo titanium dioxide, carbamide, Polyethylene Glycol, oneself is-1 years old, 2, the 6-triol is extremely about 80 ℃ of vessel in heating, use Heidolph Colophonium blade turbine blender (pitch blade turbine mixer) under 200rpm, to mix simultaneously, be cooled to 75 ℃ and interpolation Montanov 68 or Emulgade PL68/50 and EDTA disodium, prepare phase II thus.(note, if necessary, then Montanov 68 and Emulgade PL68/50 can be added in the oil phase but not aqueous phase).Before adding phase I, continue to stir other 5 minutes.Use Ultraturax T25 (IKA-Labortechnik) under 13500rpm with about 10 minutes of the mixture homogenization of phase I and II mutually, be cooled to 65 ℃ then.

If desired, the granule with phase III at room temperature is stirred in the carrier oil under 50-150rpm with the rotator type agitator.In case behind the formation homogeneous mixture, add to immediately in the phase I/ phase II emulsion.If do not have carrier oil to exist among the phase III, then granule slowly added to while stirring in the phase I/ phase II emulsion.

With the further cooling and in case when reaching 60 ℃, add Sepigel 305 and NaOH of the mixture of gained.Treat that mixture further is cooled to 50 ℃ adds remaining composition afterwards.Product with gained before packing further cools off.

Claims (19)

1. one kind is the part cosmetic composition that having of distillate medicinal water, cream or gel form contains water continuous phase, and said composition contains:

I) 0.01wt% to 25wt% median particle is the granular organic material of 0.5 to 30 μ m;

Ii) greater than the 8wt% wetting agent, be selected from glycerol, poly alkylene glycol, carbamide, D or DL pantothenylol, oneself-1,2,6-triol, guanidine or derivatives thereof, aklylene glycol such as butanediol and propylene glycol, and composition thereof;

Iii) 2wt% to 20wt% organic sunscreen agent.

2. according to the compositions of claim 1, wherein the median particle of granular organic material is 0.5 to 15 μ m, more preferably 0.7 to 10 μ m, and more preferably 1 to 7.5 μ m.

3. according to each compositions of claim 1 to 2, wherein the granular organic material is selected from organic siloxane polymer, polyethylene, polyacrylonitrile, polyacrylic acid, polymethylacrylic acid, polystyrene, politef, poly-(1, the 1-dichloroethylene), polyamide and ethylene/acrylic acid copolymer and composition thereof.

4. according to each compositions of claim 1 to 3, wherein organic granular is selected from organic siloxane polymer and composition thereof, and more preferably poly methyl silsesquioxane.

5. according to each compositions of claim 1 to 4, wherein the granular organic material has less than 50mN/m, preferably less than 40mN/m, and is more preferably less than the critical surface tension of 35mN/m.

6. according to each compositions of claim 1 to 5, contain 0.1% to 15%, the more preferably granular organic material of 0.2wt% to 5wt%.

7. according to each compositions of claim 1 to 6, wherein wetting agent is selected from glycerol or carbamide and composition thereof.

8. according to each compositions of claim 1 to 7, contain 8wt% to 30wt%, more preferably 8.5wt% to 20wt% and the more preferably wetting agent of 9wt% to 15wt%.

9. according to each compositions of claim 1 to 8, wherein the organic sunscreen agent is selected from and has the absorbefacient chemical compound of UVA or have absorbefacient chemical compound of UVB and composition thereof.

10. according to the compositions of claim 9, it is dibenzoylmethane derivative and composition thereof that wherein organic UVA absorbs sunscreen, and preferred butyl methoxydibenzoylmethise.

11. compositions according to claim 9, wherein organic UVB absorbs sunscreen and is selected from octocrylene, octyl methoxycinnamate (octomethoxy cinnamate), ethylhexyl salicylate, Phenylbenzimidazolesulfonic acid or its mixture, preferred octocrylene.

12., contain the organic sunscreen agent of 4wt% to 14wt% according to each compositions of claim 1 to 11.

13. according to each compositions of claim 1 to 12, wherein sun protection factor is preferably greater than 15 greater than 10, and wherein critical absorption wavelength greater than 370nm.

14., contain 0.1wt% to 20wt%, preferred 0.2wt% to 10wt%, the more preferably nicotiamide of 0.5wt% to 5wt% according to each compositions of claim 1 to 13.

15. according to each compositions of claim 1 to 14, it is an emulsion oil-in-water.

16. according to each compositions of claim 1 to 15, wherein granular material is pre-dispersed in the organosiloxane oil and said thus pre-composition under 31 ℃, at 20s ^-1Under viscosity less than 5000cps, preferably less than 2000cps.

17. each compositions of claim 1 to 16, wherein the organosiloxane oil content loose fluidic viscosity under 31 ℃ at 20s ^-1Down less than 350mPa.s, preferably less than 100mPa.s and be more preferably less than 75mPa.s.

18. each the purposes of compositions of claim 1 to 17, wherein said organosiloxane oil is polydimethylsiloxane preferably.

19. each compositions of claim 1 to 18 is used to transmit high level wettability and UV protectiveness and being clamminess property of low degree or adhesive purposes.