CN1425414A - Rabdosia extract and its preparing method and use - Google Patents
Rabdosia extract and its preparing method and use Download PDFInfo
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- CN1425414A CN1425414A CN 02151503 CN02151503A CN1425414A CN 1425414 A CN1425414 A CN 1425414A CN 02151503 CN02151503 CN 02151503 CN 02151503 A CN02151503 A CN 02151503A CN 1425414 A CN1425414 A CN 1425414A
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- rabdosia rubescens
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Abstract
The rabdosia extract is a kind of Chinese medicine for treating upper respiratory tract inflammation and cancer. The rabdosia extract includes coarse extract, effective part and single components. During the extraction, the cleaned rabdosia is refluxed in 8-18 times ethanol for 20 hr, filtered and depression concentrated to produce dense extractum; the dense extractum is depression dried, crushed and 100-mesh sieved to obtain the coarse extract; the dense extractum is dissolved in methanol, active carbon decolored, concentrated, dissolved in acetone, filtered and concentrated to obtain diterpene compound; the dense extractum is methanol dissolved, active carbon decolored, concentrated, dissolved in acetone, filtered, concentrated and alumina column eluted to obtain rabdosia extract A and rabdosia extract B.
Description
Technical field:
The present invention relates to a kind of Chinese medicine for the treatment of upper respiratory tract infection, reaching cancer, and its production and application.This Chinese medicine adopts Rabdosia rubescens extract to make.
Background technology:
Rabdosia rubescens has another name called Rabdosia rubescens, present existing Dong ling cao tablet, just adopt traditional Chinese medicine processing method to make, be mainly used in diseases such as treatment upper respiratory tract infection, acute and chronic pharyngitis and chronic tracheitis, its weak point is that curative effect is not fine, the dosage of taking is bigger, and the patient takes inconvenience.Contain plurality of active ingredients such as rubescensine A, second element in the Rabdosia rubescens, do not carry out effective purification processes, bring into play its excellent curative,
Summary of the invention:
The object of the invention is exactly the deficiency that overcomes above-mentioned prior art, and provide that a kind of taking dose is little, determined curative effect, can make the Rabdosia rubescens extract of multiple dosage form, and its production and application.
Rabdosia rubescens extract includes crude extract, effective site and single component.
Get and clean out and Rabdosia rubescens, add the ethanol that 8-10 doubly measures through pulverizing, reflux 20 hours, filtration, concentrating under reduced pressure make thick extractum.
Crude extract can make by following method: will make behind above-mentioned thick extractum drying under reduced pressure, pulverizing, mistake 100 mesh sieves.
Effective site is the total diterpene compounds, can make by following method: above-mentioned thick extractum is added dissolve with methanol, add 1% decolorizing with activated carbon, concentrate, add acetone solution again, get filtrate concentrating, promptly.
Single component is rubescensine A and second element, can make by following method: above-mentioned thick extractum is added dissolve with methanol, add 1% decolorizing with activated carbon, concentrate, add acetone solution again, get filtrate concentrating; With aluminium sesquioxide (AL on the concentrate
2O
3) can obtain respectively behind the post eluting.
Used ethanol adopts 95% ethanol.Methanol adopts 95% methanol; Activated carbon adopts granular; The aluminium sesquioxide post adopts neutral aluminium sesquioxide.
Adopt the Rabdosia rubescens crude extract can prepare rabdosia rubescens drops, micropill, effervescent tablet, dispersible tablet; Adopt Rabdosia rubescens effective site and single component can prepare injection and infusion solutions.
The preparation method of Rabdosia rubescens extract is: gets and cleans out and Rabdosia rubescens, add the ethanol that 8-10 doubly measures through pulverizing, and reflux 20 hours, filtration, concentrating under reduced pressure make thick extractum; To make crude extract behind thick extractum drying under reduced pressure, pulverizing, mistake 100 mesh sieves; Above-mentioned thick extractum is added dissolve with methanol, add 1% decolorizing with activated carbon, concentrate, add acetone solution again, get filtrate concentrating, promptly get the total diterpene compounds; Above-mentioned thick extractum is added dissolve with methanol, add 1% decolorizing with activated carbon, concentrate, add acetone solution again, get filtrate concentrating; To can obtain rubescensine A and second element respectively behind the aluminium sesquioxide post eluting on the concentrate.
The method for preparing rabdosia rubescens drops is: be substrate with the Macrogol 4000, add the Rabdosia rubescens crude extract, then, the speed of dripping with per minute 50--60 splashes into mixing in the liquid coolant promptly of methyl-silicone oil and liquid paraffin again.The rabdosia rubescens drops of the present invention proportioning of unit serving meter by weight is: Rabdosia rubescens crude extract 3-5 part, Macrogol 4000 are 5-9 part.
Methyl-silicone oil and liquid paraffin mix that the volume ratio of the two is a liquid paraffin in the liquid coolant: methyl-silicone oil is 1:2-4.
The method for preparing the Rabdosia rubescens effervescent tablet is: with Rabdosia rubescens crude extract, Icing Sugar, tartaric acid mix homogeneously, with 80% ethanol system soft material, 20 orders are granulated, in 50 ℃ of drying for standby; Other gets remaining Rabdosia rubescens extract, Icing Sugar and sodium bicarbonate (NaHCO
3) mix homogeneously, with 80% ethanol system soft material, 20 orders are granulated, and in 50 ℃ of dryings, then, mix with above-mentioned dried granule, granulate, add tabletting behind the magnesium stearate mixing.
The method for preparing the Rabdosia rubescens dispersible tablet is: with Rabdosia rubescens crude extract, lactose, low carboxy-propyl cellulose, the carboxymethyl starch sodium mixing of replacing, with 80% ethanol system soft material, cross 20 mesh sieves and granulate about 60 ℃ of dryings, 20 mesh sieve granulate; Then, heavily add tabletting behind carboxymethyl starch sodium, the micropowder silica gel mixing by granule.
Rabdosia rubescens extract of the present invention and preparation thereof have heat-clearing and toxic substances removing, anti-inflammatory analgetic, and antitumor action.Mainly be applicable to diseases such as treatment upper respiratory tract infection, suppurative tonsillitis, acute and chronic pharyngitis and chronic tracheitis, multiple cancers such as the esophageal carcinoma, carcinoma of gastric cardia, hepatocarcinoma, breast carcinoma are all had certain therapeutic effect.Studies confirm that through system experimentation the total diterpene compounds that extracts has significantly antibiotic and antitumor action from Rabdosia rubescens, also have the effect of immunomodulating and blocking-up esophageal epithelial proliferation simultaneously, and have slight analgesic activity.
The advantage of Rabdosia rubescens extract of the present invention and preparation thereof is a good effect, taking convenience.Through clinical verification, its curative effect has better therapeutic than similar tablet medicine, more is subjected to patient's welcome.
The specific embodiment one:
Preparation rabdosia rubescens drops: get Rabdosia rubescens crude extract 6g, Macrogol 4000 is 14g.Can make 1000 of rabdosia rubescens drops according to preceding method.
The specific embodiment two:
Preparation Rabdosia rubescens effervescent tablet: Rabdosia rubescens crude extract 51g, Icing Sugar 10g, tartaric acid 45g, sodium bicarbonate 65g, 80% ethanol is an amount of, can make 300 of Rabdosia rubescens effervescent tablets according to preceding method.
The specific embodiment three:
Preparation Rabdosia rubescens dispersible tablet: get Rabdosia rubescens crude extract 170g, lactose 30g, lowly replace carboxy-propyl cellulose 17g, carboxymethyl starch sodium (in add) 10g, carboxymethyl starch sodium (adding) 5g, micropowder silica gel 1%, 80% ethanol is an amount of, according to tabletting behind the preceding method mixing.Can be pressed into 1000 of Rabdosia rubescens dispersible tablets.
The specific embodiment four:
Preparation Rabdosia rubescens micropill: get the Rabdosia rubescens crude extract,, adopt proper honey to make the Rabdosia rubescens micropill as wetting agent according to the conventional method of micropill.
The specific embodiment five:
Preparation Rabdosia rubescens total diterpene injection: get Rabdosia rubescens total diterpene 50g, behind an amount of injection dissolve with ethanol, adding distil water is to 1000ml, and filling and sealing promptly gets Rabdosia rubescens total diterpene injection according to a conventional method.
The specific embodiment six:
Preparation Rabdosia rubescens total diterpene infusion solutions: get Rabdosia rubescens total diterpene 10g, behind an amount of injection dissolve with ethanol, adding distil water is to 10000ml, and filling and sealing promptly gets Rabdosia rubescens total diterpene infusion solutions according to a conventional method.
The specific embodiment seven:
Preparation rubescensine A injection: get rubescensine A 12.5g, behind an amount of injection dissolve with ethanol, adding distil water is to 1000ml, and filling and sealing promptly gets the rubescensine A injection according to a conventional method.
The specific embodiment eight:
Preparation rubescensine A infusion solutions: get rubescensine A 2.5g, behind an amount of injection dissolve with ethanol, adding distil water is to 10000ml, and filling and sealing promptly gets the rubescensine A infusion solutions according to a conventional method.
Selectable other embodiment of those skilled in the art of the present technique also are included in the scope set forth in the present invention.
Claims (7)
1, Rabdosia rubescens extract is characterized in that Rabdosia rubescens extract includes crude extract, effective site and single component; Get and clean out and Rabdosia rubescens, add the ethanol that 8-10 doubly measures through pulverizing, reflux 20 hours, filtration, concentrating under reduced pressure make thick extractum;
Crude extract can make with following method: will make behind above-mentioned thick extractum drying under reduced pressure, pulverizing, mistake 100 mesh sieves;
Effective site is the total diterpene compounds, and available following method makes: above-mentioned thick extractum is added dissolve with methanol, add 1% decolorizing with activated carbon, concentrate, add acetone solution again, get filtrate concentrating, promptly;
Single component is rubescensine A and second element, can make by following method: above-mentioned thick extractum is added dissolve with methanol, add 1% decolorizing with activated carbon, concentrate, add acetone solution again, get filtrate concentrating; With aluminium sesquioxide (AL on the concentrate
2O
3) can obtain respectively behind the post eluting.
2, the preparation method of Rabdosia rubescens extract as claimed in claim 1 is characterized in that getting and has cleaned out and the Rabdosia rubescens through pulverizing, and adds the ethanol that 8-10 doubly measures, reflux 20 hours, and filtration, concentrating under reduced pressure make thick extractum; To make crude extract behind thick extractum drying under reduced pressure, pulverizing, mistake 100 mesh sieves; Above-mentioned thick extractum is added dissolve with methanol, add 1% decolorizing with activated carbon, concentrate, add acetone solution again, get filtrate concentrating, promptly get the total diterpene compounds; Above-mentioned thick extractum is added dissolve with methanol, add 1% decolorizing with activated carbon, concentrate, add acetone solution again, get filtrate concentrating; To can obtain rubescensine A and second element respectively behind the aluminium sesquioxide post eluting on the concentrate.
3, Rabdosia rubescens extract as claimed in claim 1 is characterized in that used ethanol adopts 95% ethanol; Methanol adopts 95% methanol.
4, Rabdosia rubescens extract as claimed in claim 1, it is granular to it is characterized in that used activated carbon adopts; The aluminium sesquioxide post adopts neutral aluminium sesquioxide.
5, the application of Rabdosia rubescens extract as claimed in claim 1 is characterized in that being used for the treatment of diseases such as upper respiratory tract infection, suppurative tonsillitis, acute and chronic pharyngitis and chronic tracheitis.
6, the application of Rabdosia rubescens extract as claimed in claim 4 is characterized in that being used for the treatment of multiple cancers such as the esophageal carcinoma, carcinoma of gastric cardia, hepatocarcinoma, breast carcinoma.
7,, it is characterized in that to make the multiple dosage form of drop pill, micropill, effervescent tablet, dispersible tablet, injection and infusion solutions as the application of claim 5 or 6 described Rabdosia rubescens extracts.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 02151503 CN1425414A (en) | 2002-12-20 | 2002-12-20 | Rabdosia extract and its preparing method and use |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 02151503 CN1425414A (en) | 2002-12-20 | 2002-12-20 | Rabdosia extract and its preparing method and use |
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| CN1425414A true CN1425414A (en) | 2003-06-25 |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100402532C (en) * | 2006-02-10 | 2008-07-16 | 陈俊辉 | Preparation method for extracting oridonin from rabdosia |
| CN101978987A (en) * | 2010-11-18 | 2011-02-23 | 河南中医学院 | Application of herba rabdosiae rubescentis extract to preparation of medicament for treating and resisting cerebral ischemia |
| CN101347500B (en) * | 2007-07-20 | 2011-08-10 | 天津天士力制药股份有限公司 | Effective component of rabdosia and preparation and use thereof |
| CN1868503B (en) * | 2005-05-24 | 2011-10-26 | 山东绿叶天然药物研究开发有限公司 | Preparation method of extractive of Herba Rabdosiae diterpene |
| CN101919903B (en) * | 2005-05-24 | 2011-11-23 | 山东绿叶天然药物研究开发有限公司 | Method for preparing rabdosia rubescens diterpene extract |
-
2002
- 2002-12-20 CN CN 02151503 patent/CN1425414A/en active Pending
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1868503B (en) * | 2005-05-24 | 2011-10-26 | 山东绿叶天然药物研究开发有限公司 | Preparation method of extractive of Herba Rabdosiae diterpene |
| CN101919903B (en) * | 2005-05-24 | 2011-11-23 | 山东绿叶天然药物研究开发有限公司 | Method for preparing rabdosia rubescens diterpene extract |
| CN100402532C (en) * | 2006-02-10 | 2008-07-16 | 陈俊辉 | Preparation method for extracting oridonin from rabdosia |
| CN101347500B (en) * | 2007-07-20 | 2011-08-10 | 天津天士力制药股份有限公司 | Effective component of rabdosia and preparation and use thereof |
| CN101978987A (en) * | 2010-11-18 | 2011-02-23 | 河南中医学院 | Application of herba rabdosiae rubescentis extract to preparation of medicament for treating and resisting cerebral ischemia |
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