CN1425133A - 检测和识别试样中分子事件的系统和方法 - Google Patents

检测和识别试样中分子事件的系统和方法 Download PDF

Info

Publication number
CN1425133A
CN1425133A CN00817005A CN00817005A CN1425133A CN 1425133 A CN1425133 A CN 1425133A CN 00817005 A CN00817005 A CN 00817005A CN 00817005 A CN00817005 A CN 00817005A CN 1425133 A CN1425133 A CN 1425133A
Authority
CN
China
Prior art keywords
sample
fluid
signal
response
molecular
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN00817005A
Other languages
English (en)
Chinese (zh)
Inventor
罗伯特·G·查普曼
约翰·J·赫夫蒂
巴雷特·J·巴特尔
马克·A·罗兹
赵民
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Signature Bioscience Inc
Original Assignee
Signature Bioscience Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Signature Bioscience Inc filed Critical Signature Bioscience Inc
Publication of CN1425133A publication Critical patent/CN1425133A/zh
Pending legal-status Critical Current

Links

Images

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/50273—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means or forces applied to move the fluids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502769—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements
    • B01L3/502784—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements specially adapted for droplet or plug flow, e.g. digital microfluidics
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0673—Handling of plugs of fluid surrounded by immiscible fluid
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0627—Sensor or part of a sensor is integrated
    • B01L2300/0645—Electrodes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0415—Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic
    • B01L2400/0418—Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic electro-osmotic flow [EOF]
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N22/00—Investigating or analysing materials by the use of microwaves or radio waves, i.e. electromagnetic waves with a wavelength of one millimetre or more
CN00817005A 1999-10-13 2000-10-13 检测和识别试样中分子事件的系统和方法 Pending CN1425133A (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US15917599P 1999-10-13 1999-10-13
US60/159,175 1999-10-13
US19170200P 2000-03-23 2000-03-23
US60/191,702 2000-03-23

Publications (1)

Publication Number Publication Date
CN1425133A true CN1425133A (zh) 2003-06-18

Family

ID=26855720

Family Applications (1)

Application Number Title Priority Date Filing Date
CN00817005A Pending CN1425133A (zh) 1999-10-13 2000-10-13 检测和识别试样中分子事件的系统和方法

Country Status (10)

Country Link
EP (1) EP1224453A2 (fr)
JP (1) JP2003535310A (fr)
KR (1) KR20020071853A (fr)
CN (1) CN1425133A (fr)
AU (3) AU8023500A (fr)
CA (1) CA2386193A1 (fr)
IL (1) IL149001A0 (fr)
MX (1) MXPA02003815A (fr)
NO (1) NO20021687L (fr)
WO (1) WO2001027610A2 (fr)

Cited By (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1914498B (zh) * 2003-12-04 2012-01-04 麦克罗威斯克有限公司 流体探针
CN101849174B (zh) * 2007-08-11 2013-05-29 麦克罗威斯克有限公司 流体探测器
CN101617209B (zh) * 2006-03-16 2013-10-02 麦克罗威斯克有限公司 流体探针
TWI569017B (zh) * 2014-11-14 2017-02-01 Nippon Mektron Kk Coaxial probe holding mechanism and electrical characteristics check device
CN108257052A (zh) * 2018-01-16 2018-07-06 中南大学 一种在线学生知识评估方法及其系统
CN108602065A (zh) * 2015-12-23 2018-09-28 维京遗传学Fmba 用于低温吸管的rfid识别系统
CN109192250A (zh) * 2018-08-01 2019-01-11 华东理工大学 一种多相催化中克服表面物种快速迁移的加速模拟方法
JP2020098202A (ja) * 2013-03-15 2020-06-25 イナノベイト， インコーポレイテッド アッセイシステムおよびカートリッジデバイス
CN111500680A (zh) * 2013-06-25 2020-08-07 普罗格诺西斯生物科学公司 检测样品中生物靶标的空间分布的方法和系统
CN115598464A (zh) * 2022-10-08 2023-01-13 金华乐馨发制品有限公司（Cn） 一种电缆末端高低压电路的检测和修复装置及其方法
US11732292B2 (en) 2010-04-05 2023-08-22 Prognosys Biosciences, Inc. Spatially encoded biological assays correlating target nucleic acid to tissue section location
US11733238B2 (en) 2010-04-05 2023-08-22 Prognosys Biosciences, Inc. Spatially encoded biological assays
US11739372B2 (en) 2015-04-10 2023-08-29 Spatial Transcriptomics Ab Spatially distinguished, multiplex nucleic acid analysis of biological specimens
US11788122B2 (en) 2011-04-13 2023-10-17 10X Genomics Sweden Ab Methods of detecting analytes
US11866767B2 (en) 2020-05-22 2024-01-09 10X Genomics, Inc. Simultaneous spatio-temporal measurement of gene expression and cellular activity

Families Citing this family (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6586946B2 (en) * 2000-11-13 2003-07-01 Signature Bioscience, Inc. System and method for detecting and identifying molecular events in a test sample using a resonant test structure
WO2002066983A2 (fr) * 2001-02-01 2002-08-29 Signature Bioscience, Inc. Dispositif d'essai biologique destine a la detection d'evenements moleculaires
US20020168659A1 (en) * 2001-02-12 2002-11-14 Signature Bioscience Inc. System and method for characterizing the permittivity of molecular events
GB0117715D0 (en) * 2001-07-19 2001-09-12 Mrbp Res Ltd Microwave biochemical analysis
US9678038B2 (en) 2001-07-25 2017-06-13 The Trustees Of Princeton University Nanochannel arrays and their preparation and use for high throughput macromolecular analysis
AU2002337653A1 (en) 2001-07-25 2003-02-17 The Trustees Of Princeton University Nanochannel arrays and their preparation and use for high throughput macromolecular analysis
US20030032000A1 (en) * 2001-08-13 2003-02-13 Signature Bioscience Inc. Method for analyzing cellular events
KR100537504B1 (ko) 2003-01-20 2005-12-19 삼성전자주식회사 생물학적 시료 내에서의 단백질 검출을 위한 자동화된 유동 시스템
US10746680B2 (en) * 2006-11-16 2020-08-18 General Electric Company Sensing system and method
CN101765462B (zh) 2007-03-28 2013-06-05 博纳基因技术有限公司 使用纳米通道阵列的大分子分析方法
US10752949B2 (en) 2012-08-14 2020-08-25 10X Genomics, Inc. Methods and systems for processing polynucleotides
US11591637B2 (en) 2012-08-14 2023-02-28 10X Genomics, Inc. Compositions and methods for sample processing
US9701998B2 (en) 2012-12-14 2017-07-11 10X Genomics, Inc. Methods and systems for processing polynucleotides
US9567631B2 (en) 2012-12-14 2017-02-14 10X Genomics, Inc. Methods and systems for processing polynucleotides
US10323279B2 (en) 2012-08-14 2019-06-18 10X Genomics, Inc. Methods and systems for processing polynucleotides
CN114891871A (zh) 2012-08-14 2022-08-12 10X基因组学有限公司 微胶囊组合物及方法
US10273541B2 (en) 2012-08-14 2019-04-30 10X Genomics, Inc. Methods and systems for processing polynucleotides
US10584381B2 (en) 2012-08-14 2020-03-10 10X Genomics, Inc. Methods and systems for processing polynucleotides
US9951386B2 (en) 2014-06-26 2018-04-24 10X Genomics, Inc. Methods and systems for processing polynucleotides
US10221442B2 (en) 2012-08-14 2019-03-05 10X Genomics, Inc. Compositions and methods for sample processing
GB201219016D0 (en) * 2012-10-23 2012-12-05 Liverpool John Moores University Electromagnetic wave sensing
US10533221B2 (en) 2012-12-14 2020-01-14 10X Genomics, Inc. Methods and systems for processing polynucleotides
US9791453B2 (en) * 2012-12-26 2017-10-17 International Business Machines Corporation Methods for determining binding capability of target ligands with G protein-coupled receptors using translocation through nanochannels
EP3862435A1 (fr) 2013-02-08 2021-08-11 10X Genomics, Inc. Génération de codes à barres de polynucléotides
US10024851B2 (en) 2013-10-15 2018-07-17 International Business Machines Corporation Use of disulfide bonds to form a reversible and reusable coating for nanofluidic devices
US9303310B2 (en) 2013-10-15 2016-04-05 International Business Machines Corporation Nanofluidic sensor comprising spatially separated functional sensing components
US9255321B2 (en) 2013-10-15 2016-02-09 Globalfoundries Inc. Directed surface functionalization on selected surface areas of topographical features with nanometer resolution
EP4219010A1 (fr) 2014-04-10 2023-08-02 10X Genomics, Inc. Procédés d'encapsulation et de partitionnement de réactifs
US9921181B2 (en) 2014-06-26 2018-03-20 International Business Machines Corporation Detection of translocation events using graphene-based nanopore assemblies
AU2015279548B2 (en) 2014-06-26 2020-02-27 10X Genomics, Inc. Methods of analyzing nucleic acids from individual cells or cell populations
KR20170073667A (ko) 2014-10-29 2017-06-28 10엑스 제노믹스, 인크. 표적화 핵산 서열 분석을 위한 방법 및 조성물
US9975122B2 (en) 2014-11-05 2018-05-22 10X Genomics, Inc. Instrument systems for integrated sample processing
SG11201705615UA (en) 2015-01-12 2017-08-30 10X Genomics Inc Processes and systems for preparing nucleic acid sequencing libraries and libraries prepared using same
US10697000B2 (en) 2015-02-24 2020-06-30 10X Genomics, Inc. Partition processing methods and systems
EP3936619A1 (fr) 2015-02-24 2022-01-12 10X Genomics, Inc. Procédés pour la couverture ciblée de séquences d'acides nucléiques
JP6954899B2 (ja) 2015-12-04 2021-10-27 １０エックス ゲノミクス，インコーポレイテッド 核酸の解析のための方法及び組成物
WO2017197338A1 (fr) 2016-05-13 2017-11-16 10X Genomics, Inc. Systèmes microfluidiques et procédés d'utilisation
US10815525B2 (en) 2016-12-22 2020-10-27 10X Genomics, Inc. Methods and systems for processing polynucleotides
US10011872B1 (en) 2016-12-22 2018-07-03 10X Genomics, Inc. Methods and systems for processing polynucleotides
US10550429B2 (en) 2016-12-22 2020-02-04 10X Genomics, Inc. Methods and systems for processing polynucleotides
EP3545089B1 (fr) 2017-01-30 2022-03-09 10X Genomics, Inc. Procédés et systèmes de codage à barres de cellules individuelles sur la base de gouttelettes
US10844372B2 (en) 2017-05-26 2020-11-24 10X Genomics, Inc. Single cell analysis of transposase accessible chromatin
EP3445876B1 (fr) 2017-05-26 2023-07-05 10X Genomics, Inc. Analyse de la chromatine accessible par une transposase d'une cellule unique
WO2019099751A1 (fr) 2017-11-15 2019-05-23 10X Genomics, Inc. Perles de gel fonctionnalisées
US10829815B2 (en) 2017-11-17 2020-11-10 10X Genomics, Inc. Methods and systems for associating physical and genetic properties of biological particles
EP3775271A1 (fr) 2018-04-06 2021-02-17 10X Genomics, Inc. Systèmes et procédés de contrôle de qualité dans un traitement de cellules uniques

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0519250A3 (en) * 1991-06-10 1993-06-02 Miles Inc. Microparticle-labeled binding assay analyzed by microwave spectroscopy
GB2296571B (en) * 1993-07-26 1998-02-11 Phase Dynamics Inc System and method for monitoring substances and reactions
SE9700828D0 (sv) * 1997-03-07 1997-03-07 Asea Brown Boveri Förfarande och anordning för att bestämma ett flertal kvalitetsparametrar vilka beskriver tillståndet hos ett organiskt material
WO1999039190A1 (fr) * 1998-02-02 1999-08-05 Signature Bioscience Inc. Procede et appareil de detection d'evenements de liaison moleculaire

Cited By (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102269686B (zh) * 2003-12-04 2015-05-06 麦克罗威斯克有限公司 流体探针
CN1914498B (zh) * 2003-12-04 2012-01-04 麦克罗威斯克有限公司 流体探针
CN102269687B (zh) * 2006-03-16 2014-11-05 麦克罗威斯克有限公司 流体探针
CN101617209B (zh) * 2006-03-16 2013-10-02 麦克罗威斯克有限公司 流体探针
CN101849174B (zh) * 2007-08-11 2013-05-29 麦克罗威斯克有限公司 流体探测器
US11767550B2 (en) 2010-04-05 2023-09-26 Prognosys Biosciences, Inc. Spatially encoded biological assays
US11761030B2 (en) 2010-04-05 2023-09-19 Prognosys Biosciences, Inc. Spatially encoded biological assays
US11733238B2 (en) 2010-04-05 2023-08-22 Prognosys Biosciences, Inc. Spatially encoded biological assays
US11866770B2 (en) 2010-04-05 2024-01-09 Prognosys Biosciences, Inc. Spatially encoded biological assays
US11732292B2 (en) 2010-04-05 2023-08-22 Prognosys Biosciences, Inc. Spatially encoded biological assays correlating target nucleic acid to tissue section location
US11795498B2 (en) 2011-04-13 2023-10-24 10X Genomics Sweden Ab Methods of detecting analytes
US11788122B2 (en) 2011-04-13 2023-10-17 10X Genomics Sweden Ab Methods of detecting analytes
JP2020098202A (ja) * 2013-03-15 2020-06-25 イナノベイト， インコーポレイテッド アッセイシステムおよびカートリッジデバイス
CN111500680A (zh) * 2013-06-25 2020-08-07 普罗格诺西斯生物科学公司 检测样品中生物靶标的空间分布的方法和系统
US11821024B2 (en) 2013-06-25 2023-11-21 Prognosys Biosciences, Inc. Methods and systems for determining spatial patterns of biological targets in a sample
CN111500680B (zh) * 2013-06-25 2024-04-16 普罗格诺西斯生物科学公司 检测样品中生物靶标的空间分布的方法和系统
US11753674B2 (en) 2013-06-25 2023-09-12 Prognosys Biosciences, Inc. Methods and systems for determining spatial patterns of biological targets in a sample
TWI569017B (zh) * 2014-11-14 2017-02-01 Nippon Mektron Kk Coaxial probe holding mechanism and electrical characteristics check device
US11739372B2 (en) 2015-04-10 2023-08-29 Spatial Transcriptomics Ab Spatially distinguished, multiplex nucleic acid analysis of biological specimens
CN108602065A (zh) * 2015-12-23 2018-09-28 维京遗传学Fmba 用于低温吸管的rfid识别系统
CN108257052A (zh) * 2018-01-16 2018-07-06 中南大学 一种在线学生知识评估方法及其系统
CN108257052B (zh) * 2018-01-16 2022-04-22 中南大学 一种在线学生知识评估方法及其系统
CN109192250B (zh) * 2018-08-01 2021-12-07 华东理工大学 一种多相催化中克服表面物种快速迁移的加速模拟方法
CN109192250A (zh) * 2018-08-01 2019-01-11 华东理工大学 一种多相催化中克服表面物种快速迁移的加速模拟方法
US11866767B2 (en) 2020-05-22 2024-01-09 10X Genomics, Inc. Simultaneous spatio-temporal measurement of gene expression and cellular activity
CN115598464A (zh) * 2022-10-08 2023-01-13 金华乐馨发制品有限公司（Cn） 一种电缆末端高低压电路的检测和修复装置及其方法

Also Published As

Publication number Publication date
JP2003535310A (ja) 2003-11-25
WO2001027610A9 (fr) 2002-08-01
MXPA02003815A (es) 2002-09-30
KR20020071853A (ko) 2002-09-13
AU2008203111A1 (en) 2008-08-07
AU2005203756A1 (en) 2005-09-15
WO2001027610A3 (fr) 2002-03-28
NO20021687D0 (no) 2002-04-10
IL149001A0 (en) 2002-11-10
EP1224453A2 (fr) 2002-07-24
NO20021687L (no) 2002-06-12
WO2001027610A2 (fr) 2001-04-19
CA2386193A1 (fr) 2001-04-19
AU8023500A (en) 2001-04-23

Similar Documents

Publication Publication Date Title
CN1425133A (zh) 检测和识别试样中分子事件的系统和方法
US9528985B2 (en) Discontinuous fluidic systems for point-of-care analyte measurement
JP3947536B2 (ja) 液体中の検体測定方法および装置
CN104203808B (zh) 具有纳米结构电极的生物传感器
Wang et al. Capillary electrophoresis immunoassay chemiluminescence detection of zeptomoles of bone morphogenic protein-2 in rat vascular smooth muscle cells
US20030032000A1 (en) Method for analyzing cellular events
Yang et al. Automated support-resolution strategy for a one-way chemiluminescent multiplex immunoassay
Mansoorifar et al. Quantification of cell death using an impedance-based microfluidic device
US9844780B2 (en) Apparatus and platform for detection of allergen
US20210055289A1 (en) Immunoassay for an automated system
Javanmard et al. Depletion of cells and abundant proteins from biological samples by enhanced dielectrophoresis
Berry et al. AirJump: using interfaces to instantly perform simultaneous extractions
You et al. Chemoenzymatic approach for the proteomics analysis of mucin-type core-1 O-glycosylation in human serum
Li et al. Ultrafast Electrothermal Flow‐Enhanced Magneto Biosensor for Highly Sensitive Protein Detection in Whole Blood
Zhao et al. Efficient sample preparation system for multi-omics analysis via single cell mass spectrometry
Song et al. Enhancing affinity‐based electroanalytical biosensors by integrated AC electrokinetic enrichment—A mini review
Sathish et al. Toward the development of rapid, specific, and sensitive microfluidic sensors: A comprehensive device blueprint
Schumacher et al. Platform technologies for molecular diagnostics near the patient’s bedside
Rossier et al. GRAVI: robotized microfluidics for fast and automated immunoassays in low volume
Cao et al. Partitioning-Induced Isolation of Analyte and Analysis via Multiscaled Aqueous Two-Phase System
Premjeet et al. Enzyme-Linked Immuno-Sorbent Assay (ELISA), basics and it’s application: A comprehensive review
US20210278358A1 (en) Methods for Detecting Analytes in Excreta in an Analytical Toilet
Krishnamoorthy et al. Integrated electrokinetic sample focusing and surface plasmon resonance imaging system for measuring biomolecular interactions
Manshadi et al. Impedance-based neutralizing antibody detection biosensor with application in SARS-CoV-2 infection
Liu et al. Three-minute-long chemiluminescent immunoassay using dually accelerated immunoreaction by infrared heating and passive mixing

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C02 Deemed withdrawal of patent application after publication (patent law 2001)
WD01 Invention patent application deemed withdrawn after publication