CN1424103A - Chinese medicine for sub-health and its preparing method - Google Patents
Chinese medicine for sub-health and its preparing method Download PDFInfo
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- CN1424103A CN1424103A CN02159230A CN02159230A CN1424103A CN 1424103 A CN1424103 A CN 1424103A CN 02159230 A CN02159230 A CN 02159230A CN 02159230 A CN02159230 A CN 02159230A CN 1424103 A CN1424103 A CN 1424103A
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Abstract
A Chinese medicine in the form of oral liquid for treating the sub-health state by improving the activity and reactive power of body and memory, and relieving fatigue is prepared from 11 Chinese-medicinal materials including ginseng, acanthopanax bark, tortoise plastron, ganoderma, etc.
Description
Technical field
The present invention relates to the pharmaceutical preparation of intervening sub-health, more particularly, be a kind of be the pharmaceutical preparation of the intervening sub-health that makes of raw material with the herbal composite.
Background technology
Owing to the reasons such as variation of environment and life style, sub-health population is increasing, according to domestic and international statistics, has the adult of 40%-60% to be in sub-health state or experience was arranged.Subhealth state is meant a kind of intermediateness between health and the disease, shows as the unusual diseases of a series of psychosomas such as body, psychology, emotion, shows lack of preservation of spirit symptoms such as hypomnesis, insomnia and dreamful sleep, spiritlessness and weakness mostly.
It is the characteristic of Chinese medicine that the adjusting function of human body comes balance to prevent and cure diseases.Chinese medical discrimination rule by sub-health state is discovered, lack of preservation of spirit, tripe strongly fragrant insufficiency of the spleen be its main traditional Chinese medical science pathologic basis, catch its center syndrome to recuperate under medical treatment, can reach the purpose of effective intervening sub-health, to performance tcm characteristic and advantage, improve bodily fuctions's state, the generation of blocking-up disease improves tcm diagnosis and treatment subhealth state level." Chinese medicine preparation of subhealth treating and the preparation method " of some reports as the CN1370597A patent application also arranged in this respect, be to be the capsule that raw material makes with Radix Ginseng, Rhizoma Dioscoreae, Fructus Lycii, Fructus Jujubae and Cordyceps mycelium, also as the CN1090774A patent application then make " compositions of elimination fatigue of human brain " with 16 kinds of Chinese herbal medicine such as Radix Artemisia ordosicae, timothy, Herba Pteridis Multifidae, Rhizoma Acori Graminei, Radix Polygalae, Herba Menthae.We know, different Chinese herbal medicine formulas, and the degree of its therapeutic effect or intervening sub-health has marked difference.
Summary of the invention
The objective of the invention is to propose the Chinese medicine preparation of many-sided intervening sub-healths such as a kind of enhancing body vigor, raising respond and adaptive capacity, memory reinforcing, resisting fatigue.
Chinese medicine preparation of the present invention is that the Chinese herbal medicine by following portions by weight makes: Radix Ginseng 10-50 part, Radix Et Caulis Acanthopanacis Senticosi 50-250 part, Carapax et Plastrum Testudinis 40-80 part, Ganoderma 80-160 part, Fructus Schisandrae Chinensis 10-50 part, Os Draconis 40-80 part, Radix Polygalae 40-80 part, Poria 60-140 part, Flos Albiziae 40-80 part, Rhizoma Acori Graminei 10-50 part, Fructus Viticis 40-80 part.
Chinese medicine preparation of the present invention fill a prescription preferably (in parts by weight) be: Radix Ginseng 20-40 part, Radix Et Caulis Acanthopanacis Senticosi 100-200 part, Carapax et Plastrum Testudinis 50-70 part, Ganoderma 100-140 part, Fructus Schisandrae Chinensis 20-40 part, Os Draconis 50-70 part, Radix Polygalae 50-70 part, Poria 80-120 part, Flos Albiziae 50-70 part, Rhizoma Acori Graminei 20-40 part, Fructus Viticis 50-70 part.
The optimum formula of Chinese medicine preparation of the present invention (in parts by weight): 30 parts of Radix Ginsengs, 150 parts of Radix Et Caulis Acanthopanacis Senticosis, 60 parts of Carapax et Plastrum Testudiniss, 120 parts of Ganodermas, 30 parts of Fructus Schisandrae Chinensis, 60 parts of Os Draconis, 60 parts of Radix Polygalaes, 100 parts in Poria, 60 parts of Flos Albiziaes, 30 parts of Rhizoma Acori Graminei, 60 parts of Fructus Viticises.
Chinese medicine preparation of the present invention is that the concrete preparation method of oral liquid comprises following process:
(1) 10-50 part Fructus Schisandrae Chinensis, 10-50 part Rhizoma Acori Graminei, 40-80 part Fructus Viticis are extracted volatile oil with steam distillation, the aqueous solution after the distillation is collected in another container;
(2) medicinal residues of step (1) and 50-250 part Radix Et Caulis Acanthopanacis Senticosi, 40-80 Carapax et Plastrum Testudinis, 80-160 Ganoderma, 40-80 part Os Draconis, 40-80 part Radix Polygalae, 60-140 part Poria, 40-80 Flos Albiziae merge mixing;
(3) 10-50 part people participates in 60% alcohol solvent and carries out percolation with weight ratio 1: 10 dipping after 24 hours, collects percolate, reclaims behind the ethanol standby;
(4) with the medicinal residues of step (3) and the mixture mixing of step (2), the 8-10 decocting doubly that adds its weight boils 2 times, and each 2 hours, collecting decoction filtered and obtains filtrate;
(5) aqueous solution after the distillation of the filtrate of step (4) and step (1) merges, being concentrated to relative density is the extractum of 1.20-1.25 (60 ℃), be chilled to 95% ethanol that adds 2 times of amounts after the room temperature, making ethanol content is 60%, stirs, and leaves standstill 48 hours, get supernatant, filter, reclaim ethanol to not having alcohol flavor, cooling;
(6) step (5) reclaim supernatant behind the ethanol add 7.2 parts of cyclamates, 2.7 parts in Pyrusussuriensis water potassium and with the volatile oil that is equivalent to the volatile oil 4-6 mixed step of tween 80 (1) doubly, add water and adjust total amount to 1000 part, stir evenly, leave standstill, filtration, embedding, sterilization promptly obtain required oral liquid.
Advantage of the present invention and effect:
Oral liquid of the present invention is made up of tranquilizing by nourishing the heart, QI invigorating, dispersing the stagnated live-QI to relieve the stagnation of QI Chinese medicine, confirm by comprehensive further investigation, oral liquid of the present invention has the enhancing body vigor, improves respond and adaptive capacity, improves effects such as multiple raising muscle power such as memory, resisting fatigue, mentality; At center card marquis lack of preservation of spirit, the deficiency of vital energy, the stagnation of liver-QI of subhealth state, select the medicine verification of this product side of medical treatment for use; Prescription of the present invention is the product of integration of edible and medicinal herbs substantially, and is safe and reliable, is convenient to take for a long time.
Oral liquid of the present invention shows that by the rat/mouse labyrinth test energy improving memory has the improvement effect to brain intelligence, and anxiety, anxiety, sleep disorder are had tranquilizing effect; The defying age test shows, can reduce the interior old and feeble product lipofuscin content of brain with defying age, prolongs fruit and restricts the life-span; Hypoxia endurance test shows, can strengthen blood flow, improves hypoxia-bearing capability and stress ability; Swimming test shows that the effect of resisting fatigue physical strength reinforcing is arranged; The neurobiology expert of U.S. University of Rochester finds in oral liquid of the present invention " to the protective effect of rat embryo brain epithelium archeocyte " experiment; the process of neuron tubulin phosphorylation has and necessarily slows down effect under the corresponding passion condition of oral liquid of the present invention, and showing has protective effect to neurocyte.
For the curative effect of oral liquid of the present invention is described, 300 example prison beds are observed through hospital, and report content is as follows:
One, method
1. experimenter
Matched group is normal male 15 examples, the mean age 28.0 ± 1.93 (25-31 year); Normal women's 15 examples, average average annual 27.8 ± 1.85 (24-31 year) be totally 30 examples.Experimental group is no anxious critical illness male 174 examples, the mean age 61.7 ± 5.57 (55-70 year); There are not anxious critical illness women 126 examples, mean age 60.6 ± 4.23 (52-67 year), totally 300 examples.
2. medication
Prestige brain oral liquid (being oral liquid of the present invention) obeys twice every day, and each 1, every 10ml, be 1.5 months the course of treatment.
3. test item
Clinical symptoms partly comprises the hypomnesis situation, and whether headache, dizziness, tired, irritated are arranged.The part of having a medical check-up comprises memory state.The brain function comprehensive grading calculates according to picture memory, numerical span, figure sequential memory, mental arithmetic speed, mental arithmetic speed, perforation, walking speed, step pitch and lower limb angle, the long every score of lower limb.Take medicine each survey of front and back to begin a project once.
Two, testing result
The experimenter reflects that generally muscle power, energy make moderate progress.
1. prestige brain oral liquid is to the influence of brain function comprehensive grading
30 routine young experimenters are matched group, and 300 the no anxious critical illnesses of example (52-70 year) experimenters distinguish administration 1.5 months for experimental group, and the brain function comprehensive grading of administration front and back sees Table 1.
Table 1 prestige brain oral liquid is to the influence of brain function scoring
| Project | Before taking medicine | After taking medicine | |
| Matched group | The man | 154.13 ± 10.16 (15 examples) | 162.17 ± 9.21 (15 examples) |
| The woman | 152.77 ± 8.01 (15 examples) | 159.93 ± 9.45 (15 examples) | |
| Experimental group | The man | 121.35 ± 17.34 (174 examples) | 136.74 ± 18.77 (174 examples) |
| The woman | 109.56 ± 13.27 (126 examples) | 122.83 ± 15.04 (121 examples) | |
The brain function scoring increased after male's group of matched group and women's group were taken medicine, and significant difference (P＜0.01) is arranged.
2. prestige brain oral liquid is to the influence of blood fat
300 the no anxious critical illness experimenters of example (52-70 year) do the inspection of blood fat (cholesterol, triglyceride) respectively before and after taking medicine, analyze by statistics and tabulate 2:
Table 2 prestige brain oral liquid is to the influence of blood fat
After the experimenter takes prestige brain oral liquid, the Blood Lipid preceding there was no significant difference (P＞0.05) of taking medicine.Clinical symptoms, have a medical check-up, after the Comprehensive Assessment experimenter of physico-chemical examination and brain function scoring influence takes prestige brain oral liquid, generally reaction muscle power is improved, memory increases, wherein 72.7% (218/300) experimenter main suit has improved memory, headache, dizzy, obviously improvement or complete obiteration of weak symptom, the visible picture of the tongue improving situation of having a medical check-up, and the brain function comprehensive grading significantly increases, it is evident in efficacy to take medicine; 16.3% (49/300) experimenter main suit has headache, dizziness, weak sx, the no significant change of having a medical check-up, and the brain function comprehensive grading improves, and comprehensive condition took a turn for the better to some extent before this part experimenter took medicine; Before and after 11% (33/300) experimenter took medicine, main suit's symptom, the situation of having a medical check-up, physico-chemical examination, brain function comprehensive grading did not all have obvious improvement, and this part experimenter is that the medicine does no good to.
| Project | Before taking medicine | After taking medicine | The P value | |
| The man | Cholesterol | 193.25 ± 38.01 (174 examples) | 186.52 ± 33.41 (174 examples) | ??P＞0.05 |
| Triglyceride | 138.3 ± 73.28 (174 examples) | 127.07 ± 54.28 (174 examples) | ||
| The woman | Cholesterol | 198.37 ± 30.12 (126 examples) | 190.99 ± 33.54 (121 examples) | ??P＞0.05 |
| Triglyceride | 135.15 ± 68.77 (126 examples) | 125.75 ± 63.23 (121 examples) | ||
Three, conclusion
1. prestige brain oral liquid can improve experimenter's general situation, makes the picture of the tongue improving situation, and the brain function comprehensive grading raises, and wherein produce effects accounts for 72.7%, takes a turn for the better and accounts for 16.3%, invalidly accounts for 11%, total effective rate 89%.
2. prestige brain oral liquid can make experimenter's brain function comprehensive grading of age groups raise, and wherein the curative effect to the old people is more remarkable.This shows that prestige brain oral liquid is to strengthening man memory power, improvement and prevention old people's amnesia has good clinical value.
3. prestige brain oral liquid does not have tangible influence to the height of blood fat.
4. do not find gastrointestinal reaction, allergy and other toxic and side effects in the clinical practice process.
The specific embodiment
Example 1-3
The prescription of the oral liquid of this example sees Table 3:
Prescription (the unit: g) of table 3 oral liquid of the present invention
| Project | Example 1 | Example 2 | Example 3 |
| Radix Ginseng | ????15 | ????30 | ????45 |
| Radix Et Caulis Acanthopanacis Senticosi | ????200 | ????180 | ????220 |
| Carapax et Plastrum Testudinis | ????75 | ????60 | ????50 |
| Ganoderma | ????90 | ????120 | ????150 |
| Fructus Schisandrae Chinensis | ????20 | ????30 | ????40 |
| Os Draconis | ????40 | ????60 | ????75 |
| Radix Polygalae | ????70 | ????40 | ????50 |
| Poria | ????80 | ????100 | ????130 |
| Flos Albiziae | ????50 | ????60 | ????70 |
| Rhizoma Acori Graminei | ????40 | ????30 | ????20 |
| Fructus Viticis | ????50 | ????60 | ????70 |
Concrete preparation process:
Fructus Schisandrae Chinensis, Rhizoma Acori Graminei, Fructus Viticis are extracted volatile oil with steam distillation, and the aqueous solution after the distillation places another container; Seven flavors such as medicinal residues and Radix Et Caulis Acanthopanacis Senticosi merge; Radix Ginseng flooded 24 hours with 60% ethanol (by 1: 10), carry out percolation, collect percolate, reclaim ethanol, standby, medicinal residues mix with above-mentioned medicine, add water (8-10) and doubly decoct 2 times, each 2 hours, collecting decoction, filter, aqueous solution after filtrate and the distillation merges, and is concentrated into the extractum of relative density (60 ℃) 1.2-1.25, cooling, 95% ethanol that adds 2 times of amounts makes that to contain alcohol amount be 60%, stir, static 48 hours, get supernatant, filter, reclaim ethanol, cooling adds sweetener 7.2g, three flavor volatile oil such as Pyrusussuriensis potassium alcoholate 2.7g and Fructus Schisandrae Chinensis (mixing with the 4-6 that is equivalent to volatile oil weight tween 80 doubly earlier), add water and adjust total amount, stir evenly to 1000ml, leave standstill, filter, embedding, sterilization promptly gets required product.
Claims (5)
1. the Chinese medicine preparation of an intervening sub-health, it is characterized in that: it is the medicament that is made by the following portions by weight raw material: Radix Ginseng 10-50 part, Radix Et Caulis Acanthopanacis Senticosi 50-250 part, Carapax et Plastrum Testudinis 40-80 part, Ganoderma 80-160 part, Fructus Schisandrae Chinensis 10-50 part, Os Draconis 40-80 part, Radix Polygalae 40-80 part, Poria 60-140 part, Flos Albiziae 40-80 part, Rhizoma Acori Graminei 10-50 part, Fructus Viticis 40-80 part.
2. Chinese medicine preparation according to claim 1 is characterized in that: it is the medicament that is made by the following portions by weight raw material: Radix Ginseng 20-40 part, Radix Et Caulis Acanthopanacis Senticosi 100-200 part, Carapax et Plastrum Testudinis 50-70 part, Ganoderma 100-140 part, Fructus Schisandrae Chinensis 20-40 part, Os Draconis 50-70 part, Radix Polygalae 50-70 part, Poria 80-120 part, Flos Albiziae 50-70 part, Rhizoma Acori Graminei 20-40 part, Fructus Viticis 50-70 part.
3. Chinese medicine preparation according to claim 1 is characterized in that: it is the medicament that is made by the following portions by weight raw material: 30 parts of Radix Ginsengs, 150 parts of Radix Et Caulis Acanthopanacis Senticosis, 60 parts of Carapax et Plastrum Testudiniss, 120 parts of Ganodermas, 30 parts of Fructus Schisandrae Chinensis, 60 parts of Os Draconis, 60 parts of Radix Polygalaes, 100 parts in Poria, 60 parts of Flos Albiziaes, 30 parts of Rhizoma Acori Graminei, 60 parts of Fructus Viticises.
4. according to claim 1,2 or 3 described Chinese medicine preparation, it is characterized in that described medicament is an oral liquid.
5. according to the preparation method of the described Chinese medicine preparation of claim 4, it is characterized in that the preparation process of described oral liquid may further comprise the steps:
(1) 10-50 part Fructus Schisandrae Chinensis, 10-50 part Rhizoma Acori Graminei, 40-80 part Fructus Viticis are extracted volatile oil with steam distillation, the aqueous solution after the distillation is collected in another container;
(2) medicinal residues of step (1) and 50-250 part Radix Et Caulis Acanthopanacis Senticosi, 40-80 Carapax et Plastrum Testudinis, 80-160 Ganoderma, 40-80 part Os Draconis, 40-80 part Radix Polygalae, 60-140 part Poria, 40-80 Flos Albiziae merge mixing;
(3) 10-50 part people participates in 60% alcohol solvent and carries out percolation with weight ratio 1: 10 dipping after 24 hours, collects percolate, reclaims behind the ethanol standby;
(4) with the medicinal residues of step (3) and the mixture mixing of step (2), the 8-10 decocting doubly that adds its weight boils 2 times, and each 2 hours, collecting decoction filtered and obtains filtrate;
(5) aqueous solution after the distillation of the filtrate of step (4) and step (1) merges, being concentrated to relative density is the extractum of 1.20-1.25 (60 ℃), be chilled to 95% ethanol that adds 2 times of amounts after the room temperature, making ethanol content is 60%, stirs, and leaves standstill 48 hours, get supernatant, filter, reclaim ethanol to not having alcohol flavor, cooling;
(6) step (5) reclaim supernatant behind the ethanol add 7.2 parts of cyclamates, 2.7 parts in Pyrusussuriensis water potassium and with the volatile oil that is equivalent to the volatile oil 4-6 mixed step of tween 80 (1) doubly, add water and adjust total amount to 1000 part, stir evenly, leave standstill, filtration, embedding, sterilization promptly obtain required oral liquid.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN021592306A CN1217685C (en) | 2002-12-27 | 2002-12-27 | Chinese medicine for sub-health and its preparing method |
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| Application Number | Priority Date | Filing Date | Title |
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| CN021592306A CN1217685C (en) | 2002-12-27 | 2002-12-27 | Chinese medicine for sub-health and its preparing method |
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| CN1424103A true CN1424103A (en) | 2003-06-18 |
| CN1217685C CN1217685C (en) | 2005-09-07 |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100333759C (en) * | 2004-12-23 | 2007-08-29 | 赵贞平 | Pellet for nourish the brain and benefiting intelligence |
| WO2016058193A1 (en) * | 2014-10-13 | 2016-04-21 | 深圳市前海安测信息技术有限公司 | Traditional chinese medicine composition for treating suboptimal health and preparation method for same |
| CN115737761A (en) * | 2022-11-25 | 2023-03-07 | 重庆市中药研究院 | A Chinese medicinal composition for strengthening brain and improving intelligence, and its preparation method |
-
2002
- 2002-12-27 CN CN021592306A patent/CN1217685C/en not_active Expired - Fee Related
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100333759C (en) * | 2004-12-23 | 2007-08-29 | 赵贞平 | Pellet for nourish the brain and benefiting intelligence |
| WO2016058193A1 (en) * | 2014-10-13 | 2016-04-21 | 深圳市前海安测信息技术有限公司 | Traditional chinese medicine composition for treating suboptimal health and preparation method for same |
| CN115737761A (en) * | 2022-11-25 | 2023-03-07 | 重庆市中药研究院 | A Chinese medicinal composition for strengthening brain and improving intelligence, and its preparation method |
| CN115737761B (en) * | 2022-11-25 | 2024-05-03 | 重庆市中药研究院 | A Chinese medicinal composition for strengthening brain and improving intelligence, and its preparation method |
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| Publication number | Publication date |
|---|---|
| CN1217685C (en) | 2005-09-07 |
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