CN1413620A - Shugan Zhitong soft extract for treating hepatitis - Google Patents
Shugan Zhitong soft extract for treating hepatitis Download PDFInfo
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Abstract
A Chinese medicine in the form of plaster for treating hepatitis is prepared from 12 Chinese-medicinal materials including bupleurum root, scutellia root, notoginseng, red sage root, etc. through proportioning, crushing part of them, frying in oil, filter, adding minium powder, cooling to 150 deg.c, adding frankincense and myrrh, stirring, pouring in water and shaping. Its advantages are high curative effect, low cost and no by-effect.
Description
(1) technical field: the present invention relates to a kind of ointment of curing the disease.The Shugan Zhitong soft extract that particularly relates to a kind of treatment hepatitis (particularly hepatitis B, hepatitis C).
(2) background technology: hepatitis is the common transmittable disease of serious harm human health.The present known first type that has, B-mode, third type, fourth type, five types of hepatitis such as penta type.Wherein hepatitis B is to involve global infectious disease, and is big to human health risk, and its popular scope is big, the height of sickness rate, infectiousness is strong, suffers from more than the number, be other infectious disease can not compare.China is hepatitis big country, according to the interrelated data introduction, the whole nation 600,000,000 people infected hepatitis B virus, and 1.5 hundred million people that still have an appointment at present still are the carrier of hepatitis B virus, 3,000 ten thousand people that wherein have an appointment are diagnosed as hepatitis B patient, have every year more than 600 ten thousand people to add the hepatitis B patient ranks approximately.Hepatitis B is one of cause of disease of liver cirrhosis, there is 30% hepatitis B patient to transfer liver cirrhosis to approximately, has 86.7% hepatocarcinoma patient that the hepatitis B medical history is all arranged, the hepatitis B medical history is all arranged the carcinogenic patient of the known mankind, in known human carcinogen, hepatitis B virus was listed in for second (being only second to Nicotiana tabacum L.).
Domestic and international in recent years diagnosis and the treatment research to hepatitis B obtains certain progress, some novel drugs occurred.As the interferon (ZFH-a) of being praised highly by foreigner, on probation at home, effect is undesirable, and it is limited that it suppresses HBV (hepatitis B virus) effect of duplicating, and HbeAg/ is anti--and the Hbe frequence of seroconversion has only 15%～30%, and short term efficacy is poor, bounce-back rate height after the drug withdrawal; The recent domestic human grass phosphoric acid that has, the arabinose gland certain kind of berries (Ara-Amp) treatment HB obtains certain effect, the HbeAg negative conversion rate was 43.5% when finished the course of treatment, but bounce-back is arranged after the drug withdrawal equally, and the course of treatment of exceeding the time limit is relatively poor, Ara-Amp+ thymosin or Hepatitis B virus vaccine treatment HB, wherein--the effect of Ara-Amp+ thymosin is better, its HbeAg and HBVDNA negative conversion rate are 51.9% and 42.3%, but the data of following up a case by regular visits to is less, and its total phase curative effect remains further to be verified to the side effect of hepatic tissue HBV.Above-mentioned western medicine hepatitis B bounce-back is more serious, and the drug price costliness, and patient's financial burden is too heavy.
Treatment also useful Chinese medicine of hepatitis and Chinese patent medicine.But pretty troublesome with the treatment by Chinese herbs hepatitis patient, decoct medicinal herbs very time-consumingly, and the time of eating soup is long, injures one's stomach easily, and prescription generally lacks standardization, and the course of treatment is long, and time-consuming day, it was slow to take effect.
Domestic at the patent application Chinese patent drugs for treatment hepatitis prescription relevant with appearance in the mandate, as CN1094635, application number is 93111102.1 1 kinds of treatment hepatitis medicaments, with Scolopendra, Squama Manis, Spora Lygodii, Herba Hedyotidis Diffusae, Chinese herbal medicine such as Radix Salviae Miltiorrhizae, Rhizoma Curcumae is generate medicated powder in proportion, extracts active ingredient oral medicine; CN1156602, the patent No.: 96105696.6, a kind of compound Tibet capillary artemisia medicine is used Radix Bupleuri, ZANGYINCHEN, Fructus Lycii, Flos Carthami, Radix Glycyrrhizae is pulverized in proportion and makes capsule, tablet or oral liquid.The CN110690 number of applying for a patent: 94118275.4 1 kinds of treatment hepatitis medicaments, with Herba Epimedii, Rhizoma Polygoni Cuspidati, Radix Paeoniae Rubra, Herba Taraxaci, the Radix Astragali, root of subprostrate sophora, Chinese herbal medicine such as Rhizoma Smilacis Glabrae are made medicine.The patented technology Chinese patent medicine of above-mentioned treatment hepatitis, do not see at present and come into the market to sell, oral Chinese patent medicine or injection Chinese patent medicine act on the gastrointestinal absorption of flowing through again and are transported to blood again, when blood flows to liver again, could produce therapeutical effect, long and the not directly effect of required time, also there is similar problem in the injection medicine.So it is simple and direct to seek a kind of treatment, has no side effect, and can directly act on focal zone, instant effect, eutherapeutic treatment hepatitis medicament is inevitable in institute.
(3) summary of the invention: the objective of the invention is, start the beginning of hepatitis inner disease outer treat, provide a kind of heat-clearing and toxic substances removing that has, the soothing liver-QI promoting the circulation of QI, blood circulation promoting and blood stasis dispelling, eliminating mass and relieving fullness eliminating stagnation, the Shugan Zhitong soft extract of Repercusion analgesia treatment hepatitis, can be used for treating hepatitis A, hepatitis B, hepatitis C, hepatitis E, liver cirrhosis, fatty liver, alcoholic liver, liver abscess, hepatocarcinoma, cholecystitis, cholelithiasis, the medicine of cholangitis.
Technical scheme of the present invention is: a kind of Shugan Zhitong soft extract for the treatment of hepatitis, prepare by a certain percentage by relevant Chinese herbal medicine, part grinds to form medicated powder, and all the other fragmentations or hand hay cutter are bundled into granular or rod-short, put into vegetable oil and soak, pour heating frying in the pot then into, add relevant medicated powder behind the filtering residue and stir, form the medicine ointment, pour in the water and soak, extract moisture, requiring by weight to be pressed into ointment, is example with the weight portion, contains Radix Bupleuri 3～10, Radix Scutellariae 3～10, Herba Artemisiae Scopariae 6～30, Squama Manis 1～15, Carapax Trionycis 3～15, Radix Notoginseng 1～10, Radix Salviae Miltiorrhizae 5～15, Poria 10～60, Radix Et Rhizoma Rhei 3～12, vegetable oil is put in its fragmentation that is mixed soaked, the immersion dose is 1 with the ratio of vegetable oil: (2～3.5); With Olibanum 3～10, Myrrha 3～10 is ground into medicated powder, and Plumbum preparatium is 1 with the ratio that is boiled into medicine oil: (2～2.5), and will soak medical herbs and vegetable oil and go into pot heating frying together, by the time medicine is withered, when glossy black, removing slag adds the Plumbum preparatium powder and stirs, after add Olibanum again, do not have medicated powder to continue to stir, make salve oil, pour in the water soak after, squeeze the branch that anhydrates and require piecemeal to be pressed into Shugan Zhitong soft extract by weight.
Contain Radix Bupleuri 6～10, Radix Scutellariae 5～10, Herba Artemisiae Scopariae 10～30, Squama Manis 5～10, Carapax Trionycis 10～15, Radix Notoginseng 3～10, Radix Salviae Miltiorrhizae 10～15, Poria 10～30, Radix Et Rhizoma Rhei 5～10, Olibanum 5～10, Myrrha 5～10.
The particle size after cracking of medical herbs is about 3～10mm, soak time at vegetable oil is 3～7 days, medical herbs was fried medicine withered glossy black about 40～60 minutes, frankincense powder does not have medicated powder to add during less than 150 ℃ in the medicine oil temperature, and ointment weight is 10 grams/open, 15 grams/open, 30 grams/open, 50 grams/open, vegetable oil can be Oleum Brassicae campestris, Oleum Glycines, Oleum Arachidis hypogaeae semen, Oleum Gossypii semen, Oleum Helianthi, Oleum sesami or plant and mix wet goods.
The useful positive result of the present invention:
Shugan Zhitong soft extract of the present invention is through the 30 routine all kinds of hepatopath's clinical observations of Henan Prov. Inst. of Chinese Medicine ﹠ Pharmacology's subordinate Henan Province acupuncture and meridian institute, and with matched group 30 example contrasts, the Shugan Zhitong soft extract of treatment hepatitis has obvious curative effects.
In 30 routine observation groups, suffer from various hypochondriac pain patients, the course of disease 1～20 year, the age is at 20～64 years old, male 19 examples, women 11 examples, chronic hepatitis 6 examples, liver cirrhosis 8 examples, acute cholecystitis 5 examples, chronic cholecystitis 9 examples, other 2 example, its therapeutic outcome sees the following form.
Observation group and contrast groups Comparison of therapeutic table (%)
| Group | The example number | Clinic control (healing) | Produce effects | Effectively | Invalid |
| Observation group | 30 | 10(33.33) | 12(40.00) | 4(13.33) | 4(13.34) |
| Matched group | 30 | 5(16.67) | 6(20.00) | 10(33.33) | 9(30.00) |
As can be seen from the above table, after a course of treatment, observation group's clinic control rate reaches 33.33% (promptly cure and costalgia do not occur), total effective rate reaches 86.66%, and matched group clinic control rate reaches 16.67%, total effective rate reaches 70%, and the difference (P＜0.05) of handling by statistics that there was a significant difference clearlys show and uses the patient of the observation group curative effect of Shugan Zhitong soft extract obviously to be better than matched group.
(2) Shugan Zhitong soft extract detects through Henan Province's epidemic prevention station: judge that with reference to the chemical substance acute toxicity grading criteria Shugan Zhitong soft extract acute dermal toxicity belongs to actual nontoxic level; Judge that according to the skin irritation intensity evaluation Shugan Zhitong soft extract (application 4 hours) is to the animal skin nonirritant.
(3) important feature of the present invention is the beginning of having started the hepatitis inner disease outer treat, directly plaster is attached to the liver place, is convenient to dial poison, promote hepatic cell growth, increase immunologic function, easy to use, its standard meets in 2001 pertinent regulations of the Pharmacopoeia of the People's Republic of China.
(4) the present invention is a raw material with the pure natural plant medicine, and its prescription meets China's pharmacopeia pertinent regulations, utilizes the Chinese herbal treatment hepatitis of respectively distinguishing the flavor of, and human body is had no side effect.
(5) the present invention is easy to use, and is easy to carry, and storage is convenient.Shugan Zhitong soft extract is according to different patients, and ointment can directly be affixed on the liver place, umbilicus place, and kidney place.
(6) the present invention is cheap, alleviates hepatopath's financial burden greatly.
(7) the present invention is to liver cirrhosis, hepatocarcinoma, and hepatitis B, hepatitis C, hepatitis E facts have proved significant curative effect through treatment.
Model case:
1. Zhai, man, three teens, the Xi'an employee had the hepatitis B medical history 7 years, liver cirrhosis 5 years, in JIUYUE, 98 is gone on business, and because of diarrhoea causes cirrhotic ascites, lives the Xi'an large hospital, in many ways cure through the expert, still fail disease controlling, diagnose a disease upon somebody's introduction people's enlarged abdomen such as drum can not be put down for sleeping in, face is dark, the lower limb pitting edema, down in spirits is through using Shugan Zhitong patch umbilicus, liver district and two kidney districts, add the acupuncture auxiliary treatment, edema fades away, and abdominal distention disappears substantially after seven days, after more than 20 day, patient recovers normally substantially, and B ultrasonic shows the swollen all disappearances of ascites, pastes continuously again and uses the Shugan Zhitong soft extract one and a half months, hepatitis B two double inspections are all turned out cloudy, and former Xi'an hospital expert for the treatment of to him is expressed one's surprise, wonder, etc.
China certain, certain institute research worker, 96 years health sense discomforts, weak all over, shallow complexion, poor appetite to examination in hospital, is found hepatitis B, medication treatment.The state of an illness increased the weight of because of fatigue in 97 years, and the people begins to become thin, and hepatalgia with to examination in hospital, is diagnosed as hepatocarcinoma.Paste Shugan Zhitong soft extract, there is the sensation of down dragging the patient hepatic region as one gas thing being arranged at play after several days, and the back stool begins to occur the sticking the same thing that freezes, and just time increases, and the sanguinopurulent thing appears in stool behind the two weeks.This situation continues about 20 days, and behind the adhesive plaster one and a half months, the patient can go to work, behind three wheat harvesting periods, patient's energy participant entertainment sports tournament, back CT examination, focus disappears, and three of hepatitis B are turned out cloudy, anti--the Hbs positive, liver function recovery is normal, and later annual unit health check-up health is all normal.
3. river, certain laboratorian of unit infects hepatitis C because of the mammary gland blood transfusion of performing an operation, and pastes Shugan Zhitong soft extract two wheat harvesting periods, and through checking, liver function ammonia enzyme reduces to 38 by 142, and hepatitis B two double chemical examinations are all turned out cloudy except that surperficial anti-positive, and it is normal that patient body recovers substantially.
4. the Wang is over fifty years old, the hepatitis B medical history more than a year, the people becomes thin, and is tired unable, hepatalgia, poor appetite, it is poor to sleep, though through how tame hospitalize, symptom does not alleviate, upon somebody's introduction, paste Shugan Zhitong soft extract, begin half-believing, half-doubtingly, have primary disease in arms and do not have the skilful doctor, paste earlier and try, after who knew subsides one wheat harvesting period, miracle occurred, and the hepatic region is not bitterly, also not bitterly, appetite heightens waist, and it is very fragrant to sleep, antisecosis, have rosy cheeks, pasted two wheat harvesting periods after, to examination in hospital, liver function is normal substantially.
The present invention filters out the soothing the liver promoting the circulation of QI of heat-clearing and toxic substances removing, reducing swelling and alleviating pain, blood circulation promoting and blood stasis dispelling, promoting tissue regeneration by removing blood stasis, the Chinese herbal medicine of eliminating mass and relieving fullness eliminating stagnation from motherland's medicine treasure-house.Radix Bupleuri in the side is the most frequently used medicine of treatment hepatopathy.Modern pharmacological research proves that Radix Bupleuri contains saikoside, volatile oil, alkaloid etc., have analgesic, the analgesia, anti-inflammation, the hepatic cholagogic effect, its antibacterial action is similar to meticorten.Kaikosides has remarkable anti-injury recovery to the experimental animal models hepatic injury, anti-hepatic fibrosis, liver cirrhosis there is preventive and therapeutic effect, makes in its liver cirrhosis process to alleviate hepatic necrosis, prevent that the liver fatty from becoming, suppress fibroplasia, and the promotion fiber absorbs, clinical confirmation is to chronic hepatitis, hepatosplenomegaly person uses bupleurum preparation, can make liver and spleen retraction; Radix Scutellariae contains baicalin, baicalin, and skullcapflavone all has effect of reducing enzyme levels to multiple liver-fire, and the wadding the turbid descending falls in promoting the function of the gallbladder to alleviate jaundice, and effective percentage suppresses hepatitis B virus between 79～90%, experiment showed, that the Radix Scutellariae decoct has strong inhibitory action to HbeAg; The Herba Artemisiae Scopariae modern study has function of gallbladder promoting, protects the liver, and antibacterial action in the clinical practice, is used for heat-clearing and toxic substances removing, and hepatoprotective falls enzyme Artemisia anethoicles Mattf alkene and can diminish inflammation, and prevents hepatic necrosis, promotes liver cell regeneration, promotes the effect of liver inner blood circulation; Radix Et Rhizoma Rhei has antitumaous effect, and energy cholesterol reducing and triglyceride can be used for treating the fatty liver astringing to arrest bleeding, and the precipitating proteins effect promotes the wound face healing, promotes blood coagulation; Squama Manis has the merit of removing blood stasis removing food stagnancy, hepatosplenomegaly commonly used, the liver cirrhosis smelting is treated, and Carapax Trionycis has nourishing YIN for decreasing fever, the merit of hard masses softening and resolving, modern study proof Carapax Trionycis has the inhibition connective tissue proliferation, improve the plasma protein effect, the human body immunity improving ability is arranged, prolong the effect of antibody life period, be applicable to hepatosplenomegaly, liver cirrhosis; The hemostasis of Radix Notoginseng merit master dissipating blood stasis, subduing swelling and relieving pain has better hepatoprotective effect of reducing enzyme levels; Poria cures mainly that water is wet to stop gathering, the edema distension, and breast side of body feeling of fullness, modern pharmacological research proof Poria has diuresis, and is antibiotic, antitumor action.
The present invention utilizes the Radix Bupleuri sending up the lucid YANG, Radix Scutellariae the turbid descending the moon, and Herba Artemisiae Scopariae can be detoxified, this one rise and one drop one is separated, and can nurse one's health the important department that changes the negative and positive lifting, Olibanum in the side, Myrrha, Plumbum preparatium is dialled taking poison and growing muscle due, promoting tissue regeneration by removing blood stasis, full side's compatibility is played heat-clearing and toxic substances removing altogether, dampness removing jaundice eliminating, reducing swelling and alleviating pain, soothing the liver promoting the circulation of QI, the effect of eliminating mass and relieving fullness eliminating stagnation.
(4) description of drawings
Fig. 1: one of Shugan Zhitong soft extract structural representation.
Fig. 2: two of Shugan Zhitong soft extract structural representation.
(4) specific embodiment
Embodiment one, referring to Fig. 1, and 2, among the figure, 1 is circular ointment, and 2 is the ointment Tobe, and 3 is oval ointment.
Get various herbal raw materials by following proportioning, weight is unit with the kilogram: Radix Bupleuri 9, Radix Scutellariae 8, Herba Artemisiae Scopariae 30, Squama Manis 13, Carapax Trionycis 15, Radix Notoginseng 6, Radix Salviae Miltiorrhizae 15, Olibanum 6, Myrrha 6, Poria 30, Radix Et Rhizoma Rhei 12.
Production method: earlier with Olibanum, Myrrha is ground into medicated powder, crosses 100 mesh sieves, it is 3～10mm granularity that remaining medical herbs takes the circumstances into consideration to pulverize, and puts into Oleum sesami and soaks 7 days for 300 kilograms, then the frying of pot internal heating, fried withered glossy black to medicine, reduce internal heat about 40～60 minutes elimination medicinal residues when dripping into pearl, get about 150 kilograms of medicine oil, get 75 kilograms in Plumbum preparatium, Plumbum preparatium is put into medicine oil slowly stir, when the ointment of examination is tack-free, promptly from fire, when treating below the oily temperature drop to 150 ℃, add Olibanum, do not have medicated powder to stir, get salve oil 237kg, soaked about 7 days in the impouring water, pull the in bulk ointment out and remove moisture, restrain/open by 10,15 grams/open, 30 grams/open and be cut into piece are put on the pressure plaster machine again and are pressed into shape, can get 23700 on ointment, or 15800, or 7900.
Using method: earlier clean illing skin, then plaster being heated to non-scald on hand is degree, the subsides umbilicus pastes pair shen shus with 15 a grams/ellipse with 10 a grams/circle, pastes liver and restrains/open ellipse with 30.
Embodiment two: they with the kilogram unit, and Radix Bupleuri 4, Radix Scutellariae 5, Herba Artemisiae Scopariae 10, Squama Manis 3, Carapax Trionycis 4, Radix Notoginseng 3, Radix Salviae Miltiorrhizae 6, Poria 12, Radix Et Rhizoma Rhei 4, Oleum Sesami 116, Olibanum 4, Myrrha 3, Plumbum preparatium 30.
Production method does not repeat with embodiment one, about 95 kilograms of Shugan Zhitong soft extract, but 9500 of pharmacy cream, or 6333, or 3166.
Embodiment three: they with the kilogram unit Radix Bupleuri 10, and Radix Scutellariae 10, Herba Artemisiae Scopariae 28, Squama Manis 13, Carapax Trionycis 15, Radix Notoginseng 9, Radix Salviae Miltiorrhizae 14, Poria 30, Radix Et Rhizoma Rhei 10, Olibanum 10, Myrrha 8,314 kilograms of Oleum sesami, 78.5 kilograms in Plumbum preparatium.Production method does not repeat with embodiment one, about 253.5 kilograms of Shugan Zhitong soft extract, but 25350 of pharmacy cream, or 16900, or 8450.
Claims (3)
1. a Shugan Zhitong soft extract for the treatment of hepatitis is prepared by a certain percentage by relevant Chinese herbal medicine, and part grinds to form medicated powder, all the other fragmentations or hand hay cutter are bundled into granular or rod-short, put into vegetable oil and soak, and pour heating frying in the pot then into, add relevant medicated powder behind the filtering residue and stir, form the medicine ointment, pour in the water and soak, extract moisture, require by weight to be pressed into ointment, it is characterized in that: with the weight portion is example, contains Radix Bupleuri 3～10, Radix Scutellariae 3～10, Herba Artemisiae Scopariae 6～30, Squama Manis 1～15, Carapax Trionycis 3～15, Radix Notoginseng 1～10, Radix Salviae Miltiorrhizae 5～15, Poria 10～60, Radix Et Rhizoma Rhei 3～12, vegetable oil is put in its fragmentation that is mixed soaked, the immersion dose is 1 with the ratio of vegetable oil: (2～3.5); With Olibanum 3～10, Myrrha 3～10 is ground into medicated powder, and Plumbum preparatium is 1 with the ratio that is boiled into medicine oil: (2～2.5), and will soak medical herbs and vegetable oil and go into pot heating frying together, by the time medicine is withered, when glossy black, removing slag adds the Plumbum preparatium powder and stirs, after add Olibanum again, do not have medicated powder to continue to stir, make salve oil, pour in the water soak after, squeeze the branch that anhydrates and require piecemeal to be pressed into Shugan Zhitong soft extract by weight.
2. Shugan Zhitong soft extract according to claim 1 is characterized in that: contain Radix Bupleuri 6～10, Radix Scutellariae 5～10, Herba Artemisiae Scopariae 10～30, Squama Manis 5～10, Carapax Trionycis 10～15, Radix Notoginseng 3～10, Radix Salviae Miltiorrhizae 10～15, Poria 10～30, Radix Et Rhizoma Rhei 5～10, Olibanum 5～10, Myrrha 5～10.
3, Shugan Zhitong soft extract according to claim 1 and 2 is characterized in that: the particle size after cracking of medical herbs is about 3～10mm, is 3～7 days in the soak time of vegetable oil, medical herbs was fried medicine withered glossy black about 40～60 minutes, frankincense powder does not have medicated powder to add during less than 150 ℃ in the medicine oil temperature, and ointment weight is 10 grams/open, 15 grams/open, 30 grams/open, 50 grams/open, vegetable oil can be Oleum Brassicae campestris, Oleum Glycines, Oleum Arachidis hypogaeae semen, Oleum Gossypii semen, Oleum Helianthi, Oleum sesami or plant and mix wet goods.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB021154678A CN1194722C (en) | 2002-01-23 | 2002-01-23 | Shugan Zhitong soft extract for treating hepatitis |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB021154678A CN1194722C (en) | 2002-01-23 | 2002-01-23 | Shugan Zhitong soft extract for treating hepatitis |
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| Publication Number | Publication Date |
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| CN1413620A true CN1413620A (en) | 2003-04-30 |
| CN1194722C CN1194722C (en) | 2005-03-30 |
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| CNB021154678A Expired - Fee Related CN1194722C (en) | 2002-01-23 | 2002-01-23 | Shugan Zhitong soft extract for treating hepatitis |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101940771A (en) * | 2010-09-04 | 2011-01-12 | 荣成市科学技术情报研究所 | Traditional Chinese medicine for curing virus hepatitis and cirrhosis |
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2002
- 2002-01-23 CN CNB021154678A patent/CN1194722C/en not_active Expired - Fee Related
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101940771A (en) * | 2010-09-04 | 2011-01-12 | 荣成市科学技术情报研究所 | Traditional Chinese medicine for curing virus hepatitis and cirrhosis |
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| CN1194722C (en) | 2005-03-30 |
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