CN1410102A - Ointment for eliminating macula and its preparation method - Google Patents
Ointment for eliminating macula and its preparation method Download PDFInfo
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- CN1410102A CN1410102A CN 02138627 CN02138627A CN1410102A CN 1410102 A CN1410102 A CN 1410102A CN 02138627 CN02138627 CN 02138627 CN 02138627 A CN02138627 A CN 02138627A CN 1410102 A CN1410102 A CN 1410102A
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- 239000002674 ointment Substances 0.000 title claims abstract description 20
- 238000002360 preparation method Methods 0.000 title claims description 11
- 206010025421 Macule Diseases 0.000 title 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 17
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- 241000180649 Panax notoginseng Species 0.000 claims abstract description 13
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- 210000000582 semen Anatomy 0.000 claims description 47
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- XUMBMVFBXHLACL-UHFFFAOYSA-N Melanin Chemical compound O=C1C(=O)C(C2=CNC3=C(C(C(=O)C4=C32)=O)C)=C2C4=CNC2=C1C XUMBMVFBXHLACL-UHFFFAOYSA-N 0.000 description 2
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- Medicines Containing Plant Substances (AREA)
- Medicinal Preparation (AREA)
Abstract
A spot-removing ointment is prepared from 13 Chinese medicinal materials including notoginseng, apricot kernel, peach kernel, Chinese angelica root, coix seed, etc. through extracting volatile oil from part of them for ready use, recovering the alcohol filtrate from other part of them for ready use, mixing the rest ingredients with the decoction dregs after extracting volatile oil, decocting for ready use, and adding the above-mentioned extracted substances to the extract matrix. Its advantages are high curative effect (especially for chloasma), and no irritation to skin.
Description
Technical field:
The present invention relates to a kind of speckle removing ointment machin its preparation method, especially a kind of speckle removing ointment machin its preparation method that contains Chinese medicinal ingredients.
Background technology:
Pigmented spots have " freckle ", " dusty face ", " chloasma " or the like in the traditional Chinese medical science record, and it mainly comprises the multiple pigmented lesions such as freckle, chloasma, skin melanopathy of modern medicine.
The traditional Chinese medical science thinks, pigmentation disease or because ailment said due to cold or exposure is dissolved in skin, phlegm retention is steeped in internal organs; Or because internal organs grain qi and blood disorder, blood deficiency is not flourish in face; Or because deficiency of kidney-YIN, water loses scorching stagnating and gives birth to; Or because internal injury caused by excess of seven emotions, stagnation of QI due to depression of the liver, liver spleen are not respectively; Or because improper diet and overtiredness, menoxenia, or because the blood system of fire stagnation grandson network, ailment said due to cold or exposure is rich outward and send out etc. due to the reason.Modern medicine is thought, Pigmented generation is how relevant with the estrogen Metabolic disorder, be common in menoxenia, gestation, oral contraceptive and liver patient, and the tanning by the sun of daylight, psychic trauma etc. are common inducement, estrogen, Progesterone shine with sight all can promote melanic metabolism.Melanin results from the melanocyte of basal layer, forms DOPA (dopa) by tyrosine through the hydroxylation of copper bearing tryrosinase, forms through oxidation again.
At its main pathogenesis, all smear based on medicine for external use, suitably cooperates methods such as oral medicine, massage by control in treatment for Chinese and western medicine, and medicine for external use commonly used at present has 3% Hydrochinone Cream or speckle removing frost etc., and effect is unsatisfactory.
Summary of the invention:
The present invention is directed to the problem that present medicine for removing speckle exists, a kind of speckle removing ointment machin its preparation method is provided.
Solution of the present invention mainly based on motherland's medical science to Pigmented understanding and Therapeutic Principle, rule of treatment promoting blood circulation by removing wind, row stagnates, speckle removing is main, by the theory of Chinese medical science prescription, skims the cream off milk, and is dissolved in mastic.
The medicine that speckle removing ointment involved in the present invention contains is by extracting in following component (by weight) scope:
Rhizoma Chuanxiong: 10-25, Radix Notoginseng: 10-25, Semen Armeniacae Amarum: 20-35, Semen Persicae: 20-35,
Semen Pharbitidis: 20-35, the Radix Angelicae Dahuricae: 10-25, Rhizoma Typhonii (processed): 5-15, Retinervus Luffae Fructus: 20-35,
Radix Angelicae Sinensis: 5-15, Semen Coicis: 20-35, Bombyx Batryticatus: 5-15, Radix Ampelopsis: 10-25,
Radix Scutellariae: 5-15,
The medicine that speckle removing ointment involved in the present invention contains is by extracting in following preferred ingredient (by weight) scope:
Rhizoma Chuanxiong: 10-20, Radix Notoginseng: 10-20, Semen Armeniacae Amarum: 20-30, Semen Persicae: 20-30,
Semen Pharbitidis: 20-30, the Radix Angelicae Dahuricae: 10-20, Rhizoma Typhonii (processed): 5-10, Retinervus Luffae Fructus: 20-30,
Radix Angelicae Sinensis: 5-10, Semen Coicis: 20-30, Bombyx Batryticatus: 5-10, Radix Ampelopsis: 10-20,
Radix Scutellariae: 5-10.
The medicine that speckle removing ointment involved in the present invention contains is by extracting in following optimum weight part proportioning:
Rhizoma Chuanxiong: 18, Radix Notoginseng: 15, Semen Armeniacae Amarum: 30, Semen Persicae: 30,
Semen Pharbitidis: 30, the Radix Angelicae Dahuricae: 18, Rhizoma Typhonii (processed): 9, Retinervus Luffae Fructus: 30,
Radix Angelicae Sinensis: 9, Semen Coicis: 25, Bombyx Batryticatus: 9, Radix Ampelopsis: 18,
Radix Scutellariae: 9.
The preparation method that contains the speckle removing ointment of said medicine component is:
A, Radix Angelicae Sinensis, Rhizoma Chuanxiong are soaked,, collected volatile oil and preserve standby with way of distillation distillation;
B, Radix Notoginseng, Semen Armeniacae Amarum, Semen Persicae, Semen Coicis, Semen Pharbitidis, the Radix Angelicae Dahuricae added 75% ethanol merceration after, heating and refluxing extraction reclaims the ethanol filtrate for later use;
C, the Radix Angelicae Sinensis behind Radix Scutellariae, Bombyx Batryticatus, Rhizoma Typhonii (processed), Radix Ampelopsis, Retinervus Luffae Fructus and the extraction volatile oil, Rhizoma Chuanxiong medicinal residues merged decoct with water filtration, filtrate for later use;
D, will process each standby Chinese medicinal ingredients of extracting and add in mastic substrate.
According to the speckle removing ointment that the present invention makes, done the clinical efficacy checking, the result is as follows:
No.3 People's Hospital, Hangzhou City. lasts eight months and adopts different Therapeutic Method to carry out clinical verification to 156 routine patient with chloasma groupings.Treatment time is selected in June November to next year.
In 156 routine patients, male's 5 examples, women's 151 examples, age 17-45 year, the course of disease 1 month-5 years was wherein taken contraceptive before the 5 routine onsets for a long time, and 13 exceptions apply some make up, 9 routine morbidities and emotion and overwork relevant, 21 routine menoxenias, all pigment is deepened after the case Exposures to Sunlight.
Before the treatment, we select 126 examples to adopt the speckle removing Ointment in Treatment that the present invention relates to, and apply ointment every day 3 times, back massage 3-5 minute of at every turn applying ointment.This group is called the treatment group; Another group adopts traditional 3% Hydrochinone Cream treatment for remaining 30 examples, and method is with the treatment group, and this group is called matched group.Two groups of comparing results see Table 1.
Table 1:
| Group | Curative effect | Recovery from illness | Produce effects | Effectively | Invalid | Effectively total | |||||
| The example number | Example | ???％ | Example | ??％ | Example | ???％ | Example | ???％ | Example | ???％ | |
| The treatment group | ?126 | ?24 | ???19 | ?36 | ?28.57 | ?44 | ?34.92 | ?22 | ?17.46 | ?104 | ??82.5 |
| Matched group | ??30 | ?2 | ???6.67 | ?7 | ?23.33 | ?9 | ?30 | ?12 | ?40 | ?18 | ??60 |
Above-mentioned experiment showed, the invention has the advantages that: the silt because Radix Notoginseng, Radix Angelicae Sinensis, Semen Persicae, Rhizoma Chuanxiong in the prescription are invigorated blood circulation; Radix Scutellariae clearing away heat and cooling blood, speckle removing are sun-proof; The Radix Angelicae Dahuricae, Rhizoma Typhonii, Semen Pharbitidis, Bombyx Batryticatus are to dispel facial ailment said due to cold or exposure; Retinervus Luffae Fructus is invigorated blood circulation, collateral dredging dispels the wind, more than ten flavors invigorate blood circulation clearing away heat and expelling wind altogether for our principal agent, other is equipped with Semen Coicis skin moistening flour; Radix Ampelopsis, Semen Armeniacae Amarum clearing away heat to dispel wind, this prescription closely becomes the main diseases of speckle formation because of carrying out reasonable formula around wind, fire, these three of blood stagnation, non-stimulated in the use to skin, help improving the capillary of skin permeability, promote subcutaneous circulation, tryrosinase there is stronger suppression ratio, the treatment chloasma is had effect preferably.
The specific embodiment:
Take by weighing raw material of Chinese medicine (kilogram) according to following proportioning
Rhizoma Chuanxiong: 18, Radix Notoginseng: 15, Semen Armeniacae Amarum: 30, Semen Persicae: 30,
Semen Pharbitidis: 30, the Radix Angelicae Dahuricae: 18, Rhizoma Typhonii (processed): 9, Retinervus Luffae Fructus: 30,
Radix Angelicae Sinensis: 9, Semen Coicis: 25, Bombyx Batryticatus: 9, Radix Ampelopsis: 18,
Radix Scutellariae: 9.
Concrete preparation method is as follows:
A, Radix Angelicae Sinensis, Rhizoma Chuanxiong are added 16 times of water gagings soaked 2-3 hour,, collect volatile oil and preserve standby with way of distillation distillation 6 hours;
B, Radix Notoginseng, Semen Persicae, Semen Coicis, Semen Pharbitidis, the Radix Angelicae Dahuricae are added 7 times of amount 75% ethanol mercerations after 48 hours, heating and refluxing extraction 2 hours adds 6 times of amount 75% ethanol extractions 2 hours for the second time, filters while hot, and merging filtrate reclaims the ethanol filtrate for later use;
C, the Radix Angelicae Sinensis behind Radix Scutellariae, Bombyx Batryticatus, Rhizoma Typhonii (processed), Radix Ampelopsis, Retinervus Luffae Fructus and the extraction volatile oil, Rhizoma Chuanxiong medicinal residues are merged, add 8 times of water gagings at every turn and decoct twice, each 2 hours, filter, merging filtrate is standby;
D, get 10 kilograms of stearic acid, 25 kilograms of glyceryl monostearate, 20 kilograms of 16 octadecanol, 20 kilograms of lanolines, 120 kilograms of liquid paraffin, 10 kilograms of azones, 0.6 kilogram of methyl parahydroxybenzoate, 1.4 kilograms of propyl p-hydroxybenzoate, 10 kilograms of ethoxyquin ylmethyl glycoside stearates, 25 kilograms of oxybenzones, mix to add in the vapour jacket pot and be heated to 95 ℃ while stirring, filter impurity, with filtrate vacuum heat-preserving half an hour, wait to be cooled to 85 ℃ and get oil phase, be incubated standby;
E, get 8 kilograms of methylglucoside stearates, 30 kilograms of glycerol, 50 kilograms of propylene glycol and standby ethanol extract, filtrate and water adds in the vapour jacket pot, be heated to 95 ℃ while stirring, be incubated half an hour, filtered while hot, when waiting to be cooled to 85 ℃, add insulation standby oil phase and Alpha-Methyl ionoionone 1000ml, the formation mastic stirs.
Product according to the present embodiment preparation is faint yellow, and the milkiness mastic has gloss and flower type fragrance, because the Chinese medicine ingredients decolouring can influence its effect, is difficult for decolouring in the production, and color can realize by the matrix formulations of adjusting except that the Chinese medicine composition.
Claims (6)
1, a kind of speckle removing ointment is characterized in that: contain the medicament that following weight proportioning raw material is made in the mastic substrate:
Rhizoma Chuanxiong: 10-25, Radix Notoginseng: 10-25, Semen Armeniacae Amarum: 20-35, Semen Persicae: 20-35,
Semen Pharbitidis: 20-35, the Radix Angelicae Dahuricae: 10-25, Rhizoma Typhonii (processed): 5-15, Retinervus Luffae Fructus: 20-35,
Radix Angelicae Sinensis: 5-15, Semen Coicis: 20-35, Bombyx Batryticatus: 5-15, Radix Ampelopsis: 10-25,
Radix Scutellariae: 5-15.
2, speckle removing ointment according to claim 1 is characterized in that: contain the medicament that following weight proportioning raw material is made in the mastic substrate:
Rhizoma Chuanxiong: 10-20, Radix Notoginseng: 10-20, Semen Armeniacae Amarum: 20-30, Semen Persicae: 20-30,
Semen Pharbitidis: 20-30, the Radix Angelicae Dahuricae: 10-20, Rhizoma Typhonii (processed): 5-10, Retinervus Luffae Fructus: 20-30,
Radix Angelicae Sinensis: 5-10, Semen Coicis: 20-30, Bombyx Batryticatus: 5-10, Radix Ampelopsis: 10-20,
Radix Scutellariae: 5-10.
3, speckle removing ointment according to claim 1 is characterized in that: contain the medicament that following weight proportioning raw material is made in the mastic substrate:
Rhizoma Chuanxiong: 18, Radix Notoginseng: 15, Semen Armeniacae Amarum: 30, Semen Persicae: 30,
Semen Pharbitidis: 30, the Radix Angelicae Dahuricae: 18, Rhizoma Typhonii (processed): 9, Retinervus Luffae Fructus: 30,
Radix Angelicae Sinensis: 9, Semen Coicis: 25, Bombyx Batryticatus: 9, Radix Ampelopsis: 18,
Radix Scutellariae: 9.
4, a kind of preparation method that contains the speckle removing ointment of the described drug component of claim 1 is characterized in that:
A, Radix Angelicae Sinensis, Rhizoma Chuanxiong are soaked, collected volatile oil with way of distillation distillation and preserve standby;
B, Radix Notoginseng, Semen Armeniacae Amarum, Semen Persicae, Semen Coicis, Semen Pharbitidis, the Radix Angelicae Dahuricae added 75% ethanol merceration after, heating and refluxing extraction reclaims ethanol, filtrate for later use;
C, the Radix Angelicae Sinensis behind Radix Scutellariae, Bombyx Batryticatus, Rhizoma Typhonii (processed), Radix Ampelopsis, Retinervus Luffae Fructus and the extraction volatile oil, Rhizoma Chuanxiong medicinal residues are merged, decoct with water filtration, filtrate for later use;
D, will process each standby Chinese medicinal ingredients of extracting and add in mastic substrate.
5, the preparation method of speckle removing ointment according to claim 4 is characterized in that: described Radix Angelicae Sinensis, Rhizoma Chuanxiong add 16 times of water gagings and soaked 2-3 hour, with way of distillation distillation 6 hours, collect volatile oil and preserve standby; Described Radix Notoginseng, Semen Armeniacae Amarum, Semen Persicae, Semen Coicis, Semen Pharbitidis, the Radix Angelicae Dahuricae added 7 times of amount 75% ethanol mercerations after 48 hours, and heating and refluxing extraction 2 hours adds 6 times of amount 75% ethanol extractions 2 hours for the second time, filters while hot, and merging filtrate reclaims the ethanol filtrate for later use; Radix Angelicae Sinensis behind described Radix Scutellariae, Bombyx Batryticatus, Rhizoma Typhonii (processed), Radix Ampelopsis, Retinervus Luffae Fructus and the extraction volatile oil, Rhizoma Chuanxiong medicinal residues merge, and add 8 times of water gagings at every turn and decoct twice, each 2 hours, filter, merging filtrate is standby.
6, according to the preparation method of claim 4 or 5 described speckle removing ointment, it is characterized in that: can follow these steps to add standby Chinese medicinal ingredients in the mastic substrate:
A, by weight ratio get 10 parts of stearic acid, 25 parts of glyceryl monostearate, 20 parts of 16 octadecanol, 20 parts of lanolines, 120 parts of liquid paraffin, 10 parts of azones, 0.6 part of methyl parahydroxybenzoate, 1.4 parts of propyl p-hydroxybenzoate, 10 parts of ethoxyquin ylmethyl glycoside stearates, 25 parts of oxybenzones, mix to add in the vapour jacket pot and be heated to 95 ℃ while stirring, filter impurity, 95 ℃ of vacuum heat-preservings of filtrate half an hour, wait to be cooled to 85 ℃ and get oil phase, be incubated standby;
B, get 8 parts of weight proportion methylglucoside stearates, 30 parts of glycerol, 50 parts of propylene glycol and standby Chinese medicine ethanol extract, filtrate and water adds in the vapour jacket pot, be heated to 95 ℃ while stirring, be incubated half an hour, filtered while hot, when waiting to be cooled to 85 ℃, add insulation standby oil phase and Alpha-Methyl ionoionone, the formation mastic stirs.
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| Application Number | Priority Date | Filing Date | Title |
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| CNB021386277A CN100446801C (en) | 2002-11-21 | 2002-11-21 | Ointment for eliminating macula and its preparation method |
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| Application Number | Priority Date | Filing Date | Title |
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| CNB021386277A CN100446801C (en) | 2002-11-21 | 2002-11-21 | Ointment for eliminating macula and its preparation method |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108126071A (en) * | 2016-12-01 | 2018-06-08 | 丹阳市金土地景观苗木专业合作社 | A kind of almond masking liquid and preparation method thereof |
| CN108126072A (en) * | 2016-12-01 | 2018-06-08 | 丹阳市金土地景观苗木专业合作社 | A kind of cactus masking liquid and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| JP3063565B2 (en) * | 1995-03-29 | 2000-07-12 | 株式会社田村電機製作所 | Identification information setting method |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108126071A (en) * | 2016-12-01 | 2018-06-08 | 丹阳市金土地景观苗木专业合作社 | A kind of almond masking liquid and preparation method thereof |
| CN108126072A (en) * | 2016-12-01 | 2018-06-08 | 丹阳市金土地景观苗木专业合作社 | A kind of cactus masking liquid and preparation method thereof |
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