CN1408343A

CN1408343A - Nano material medicine or food

Info

Publication number: CN1408343A
Application number: CN01128238A
Authority: CN
Inventors: 焦柏忠
Original assignee: Individual
Current assignee: Individual
Priority date: 2001-09-29
Filing date: 2001-09-29
Publication date: 2003-04-09

Abstract

The nano material medicine or food consists of natural medicine material or nutritious material of grain size of 30-100 nm in 1-15% and medicine supplementary material or food material. The natural material may be utilized fully, and the effective component may be absorbed in high utilization. The present invention has less side effects and is safe, reliable and low in cost.

Description

Nano material medicine or food

(1) technical field

What the present invention relates to is a kind of raw-material medicine or food of containing, particularly a kind of medicine or food that derives from natural drug or nutrient material.

(2) technical background

Many natural materials not only can be used as food, but also can be used as medicine.Utilize natural material to make medicine or nutraceutical,, guarantee the quality of product, adopt extraction method that natural material is carried out re-using after the processed more in order to guarantee that main component wherein can be absorbed preferably.But when extracting natural drug effective ingredient and nutritional labeling, cause the waste of other composition easily.Simultaneously, body surface transdermal administration, human body mucosal drug delivery and drug administration by injection all because the granule in medicine or the food system is excessive, can not make medicine or nutritional labeling be absorbed well or transport in blood, also are easy to generate various untoward reaction simultaneously.

(3) summary of the invention

The object of the present invention is to provide a kind of composition of natural material to be fully used, be absorbed and used easily, reduce the nano material medicine or the food of raw materials consumption.The object of the present invention is achieved like this: the raw material that it makes medicine adjuvant or making food by the particle diameter of 1-15% at natural drug or the nutrient material of 30～100nm is formed.Described natural drug or nutrient material comprise generally acknowledged natural drug and the raw material that can be used in the food.What the present invention adopted is these materials are pulverized the whole 30～100nm of the being granular systems that obtain in liquid pulverizing liquid, or the effective ingredient in them and the whole of liquid formation are the oil-in-water type or the water-in-oil type microemulsion of 30～100nm granular system.Nanoscale processing can have two kinds of forms, a kind of system of pulverizing the granule that directly obtains in 30～100nm scope for solid in liquid; The granule that the another kind of granule that forms in water-based system for butyrous effective ingredient forms in the oiliness system at the effective ingredient of the water oil-packaging type micro-emulsion of 30～100nm scope or aqueous is at the water-in-oil type microemulsion of 30～100nm scope.Specific product of the present invention can comprise: 1, pass through the medicine of skin surface transdermal administration, for example: unguentum, membrane, liniment, gel, cataplasma etc.It is that the Transdermal absorption of passing through the skin of body surface enters blood that medicine enters blood of human body circulation process.2, pass through the medicine of human body mucosal drug delivery, for example: oral mucosa form of administration, pulmonary's mucosal drug delivery dosage form, vaginal mucosa form of administration, rectal mucosa form of administration etc.Medicine enters blood of human body circulation process and enters blood for the mucosa through human body absorbs.3, oral drug, food, beverage, for example: tablet, capsule, oral liquid etc.Effective ingredient in medicine, food or the beverage enters blood of human body circulation process and enters blood for absorbing through the digestive system after oral.4, by the medicine of injection system administration, medicine enters blood of human body circulation process makes medicine directly enter blood for the method through injection.The composition that product of the present invention has in the natural material can be fully used, the absorption rate height of effective ingredient, medication or edible advantages such as to produce dysgenic probability little, safe and reliable, and cost of manufacture is low.

(4) specific embodiments

Illustrate below the present invention done more detailed description:

Embodiment 1, in the substrate of membrane, liniment, add natural drug or the effective ingredient of the particle diameter of 2-5%, make body surface administration product in the 30-100 nanometer.For example 1. make at dosage forms such as position externally used pastes such as muscle, soft tissue of joint, tincture water preparation, membrane etc., be used for the treatment of arthritis and athletic injury, can produce better curative effect with Chinese prescriptions such as Radix Tripterygii Wilfordii, Herba speranskiae tuberculatae, Flos Carthami, Rhizoma Corydalis, Herba Asaris.The membrane that obtains with the method, the effective ingredient permeability of liniment are very fast, and assimilation effect is better.2. the Chinese medicine of the anti-various skin fungus of forming with Rhizoma Coptidis, Cortex Phellodendri, Radix Scutellariae, Herba Taraxaci, Fructus Arctii, Flos Chrysanthemi, Herba Violae, Flos Lonicerae, the Radix Rehmanniae, Radix Arnebiae (Radix Lithospermi), Alumen, Fructus Psoraleae, Rhizoma Polygoni Cuspidati, Galla Chinensis, Stichopus japonicus etc. (as violet hair moss bacterium, permitted the yellow moss bacterium of Lan Shi, rust budlet spore moss bacterium etc.).Fungus-caused dermatosis is had good curative effect.3, the hemostasis class Chinese medicine of forming with Radix Notoginseng, Herba Cirsii, Radix Cirsii Japonici, the Pseudobulbus Bletillae (Rhizoma Bletillae), Pollen Typhae, Radix Rubiae, Folium Artemisiae Argyi, Radix Sanguisorbae, Flos Sophorae, Rhizoma Imperatae, Herba Agrimoniae, Folium Callicarpae Formosanae etc.Its surface area enlarges markedly, and helps strengthening anastalsis.

Embodiment 2, add natural drug or the effective ingredient of the particle diameter of 5-10% in the 30-100 nanometer in mucosal drug delivery preparation, make mucosal drug delivery preparation, the effective ingredient permeability in the preparation is very fast, and assimilation effect is better.As: 1, antipyretic and antidotal type Chinese medicine such as Rhizoma Coptidis, Cortex Phellodendri, Radix Scutellariae, Herba Taraxaci, Fructus Arctii, Flos Chrysanthemi, Herba Violae, Flos Lonicerae, the Radix Rehmanniae, Radix Arnebiae (Radix Lithospermi), Fructus Forsythiae, Bulbus Allii, Rhizoma Fagopyri Dibotryis, the Rhizoma Anemarrhenae, Radix Paeoniae Rubra, Herba Houttuyniae etc. are made dosage forms such as unguentum, tincture water preparation, membrane with substrate, adjuvant, be used for the treatment of disease in mouth.2. the buccal lozenge that the prescription of the significant Chinese medicine for the treatment of cardiovascular disease effect or their compatibilities such as Moschus, Calculus Bovis, Venenum Bufonis, Styrax, Borneolum Syntheticum, Olibanum, Lignum Santali Albi, Radix Aristolochiae, Lignum Aquilariae Resinatum, Flos Caryophylli, Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong etc. are made, drug effect can be faster.

Embodiment 3, in oral drug, food, beverage, add natural drug or the effective ingredient of the particle diameter of 1-3%, make body surface administration product in the 30-100 nanometer.Be convenient to the comprehensive utilization of ingredient, improve curative effect.As: 1, Radix Dauci Sativae is pulverized a large amount of the dissociating in nano-pulverization liquid of beta-carotene that contains in its fiber of back through nanoscale, and the leaching rate of the effective ingredient in the Radix Dauci Sativae (β-Radix Dauci Sativae) obviously improves.The effect of the health food of Zhi Zuoing, functional food, beverage can significantly be strengthened like this.2, the water-soluble composition that is utilized by human body of misfortunes such as oleanolic acid is dispersed in the availability that can improve human body in the oil-in-water nanoscale system, produces stronger therapeutical effect with littler dose.

Embodiment 4, contain the medicine of nanoscale microemulsion by the injection system administration.In injection, add the nanoscale microemulsion of natural drug effective ingredient or nutritional labeling, be injected directly into blood circulation, make medicine prevent that without " first-pass effect " of liver medicine from earlier at intrahepatic metabolism, improving curative effect.The effective ingredient that forms the nanoscale microemulsion is simultaneously utilized by human body easily, improves " bioavailability ".As: liposoluble constituents such as TANSHINONES are made nanoscale water oil-packaging type micro-emulsion injection, can obviously improve the bioavailability of TANSHINONES, improve the curative effect of medicine.

Claims

1, a kind of nano material medicine or food is characterized in that: it by the particle diameter of 1-15% at natural drug or nutrient material and the making medicine adjuvant of 30～100nm or make that the raw material of food forms.

2, nano material medicine according to claim 1 or food is characterized in that: described natural drug or nutrient material comprise generally acknowledged natural drug and the raw material that can be used in the food.

3, according to claim 1,2 described nano material medicine or food, it is characterized in that: the dosage form of product is externally used paste, tincture water preparation, membrane.

4, according to claim 1,2 described nano material medicine or food, it is characterized in that: the dosage form of product is a mucosal drug delivery preparation.

5, according to claim 1,2 described nano material medicine or food, it is characterized in that: the dosage form of product is oral drug, food, beverage.

6, according to claim 1,2 described nano material medicine or food, it is characterized in that: the dosage form of product is an injection.