CN1408257A - Separating and extracting method for date cyclic nucleotide syrup, dietary fibre and date wax - Google Patents
Separating and extracting method for date cyclic nucleotide syrup, dietary fibre and date wax Download PDFInfo
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- CN1408257A CN1408257A CN02130757A CN02130757A CN1408257A CN 1408257 A CN1408257 A CN 1408257A CN 02130757 A CN02130757 A CN 02130757A CN 02130757 A CN02130757 A CN 02130757A CN 1408257 A CN1408257 A CN 1408257A
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- jujube
- date
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- wax
- cyclic nucleotide
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Abstract
The pulp of ripe data, after being dried, cooled and crushed, is ethanol extracted; the residual dreg after ethanol extraction is steamed and dried to produce dietary fiber powder; the extracted liquid is concentrated to recover ethanol and extracted with organic solvent to separate data wax; and the raffinate is concentrated to obtain date cyclic nucleotide syrup. The said process can produce several kinds of data products of different active components and different physical and chemical property, and the data products include functional health dietary fiber and date cyclic nucleotide syrup as tonic for people with delicate constitution.
Description
Technical field
The present invention relates to the extractive technique of the effective constituent of fruit, a kind of method of from jujube, extracting bioactive ingredients of more specifically saying so.
Background technology
Jujube is the Rhamnaceae jujube, contain multiple bioactive ingredients (comprising: cyclic monophosphate, cyclopeptide alkaloid, vegetable polysaccharides, pectin, xitix, ursolic acid, Oleanolic Acid, organic acid and mineral nutrient element etc.) in the fruit, has multiple pharmacological effect, being classified as the dietotherapeutic kind by health ministry, is the distinctive Biological resources of China.The kind of present domestic jujube converted products is a lot, comprising: candied date, date nourishing crystalline substance, jujube tea, jujube paste, jujube wine, date haematochrome etc., but these goods are generally rough-wrought product, it is that whole pulp with jujube are that raw material is implemented, the general separation and Extraction that does not relate to effective constituent, do not accomplish to make the best use of everything, thereby be difficult to guarantee the health-care effect of product yet.
Summary of the invention
The purpose of this invention is to provide a kind of method of from jujube, extracting cyclic monophosphate (cAMP) syrup, food fibre (dietary fiber) and jujube wax, thereby guarantee the health-care effect of product, and the purpose that jujube is now rationally utilized.
Separating and extracting method of the present invention may further comprise the steps:
1. be 0.06-0.098MPa with ripe jujube pulp in vacuum tightness, 60-100 ℃ of following vacuum-drying, pulverize dried jujube pulp cooling back, with ethanol the pure soluble components lixiviate in the jujube powder is come out, alcoholic acid content 60-100% (volume/volume) in solvent during lixiviate, the etoh solvent content of optimizing is 75-95%, perhaps flatten sophisticated dried jujube broken, directly extract with the ethanol circulation, obtain alcohol extract and alcohol extracting residue, described extracting mode comprises percolation, single-stage or multistage pickling process, the continuous countercurrent extraction, circumfluence method (Lv Guiyuan, Wang Yitao compiles, " Chinese medicine new product development ", Beijing, the People's Health Publisher, 1997:289);
2. make the jujube dietary fibrin powder after the alcohol extracting residue solvent evaporated that step (1) obtains, through sieve, compressing tablet or encapsulated, make jujube meals cellulose tablet or capsule, wherein main component is: solubility jujube polysaccharide (40%), Mierocrystalline cellulose (30%), crude protein (18%);
3. step (1) gained alcohol extract concentrates earlier and reclaims ethanol, isolates jujube wax with organic solvent extraction then, is used for refining pharmaceutical cpd triterpenic acid and alkaloid, and described organic solvent comprises ethyl acetate, ether, butanols, amylalcohol, sherwood oil and tool mixture.
4. the raffinate of step (2) is made date cyclic nucleotide syrup with method of enrichment, and cyclic monophosphate content wherein can reach 100 microgram/grams, soluble solid content 65-72% (weight).
The jujube polysaccharide amount adopts the analysis of alcohol precipitation weighting method, cellulosic amount to adopt the analysis of acid elution method in step (2) the jujube food fibre, and crude protein quantity adopts the Kjeldahl determination analysis.
Advantage of the present invention and effect:
(1) the present invention's separation and Extraction from date goes out to have the new type of health function meals jujube Mierocrystalline cellulose of whole intestines fat-reducing effect, this product has overcome the shortcoming of the high sugar of traditional date converted products, high calorie, product has characteristics such as high protein intestines effect low in calories, whole is obvious, and aspects such as toxin expelling, lead discharging, regulating blood fat can be used for losing weight.
(2) the jujube wax that separation and Extraction goes out from jujube wherein contains various active compositions such as triterpenic acid, can be used for the multiple active skull cap components of further separation and Extraction.
(3) from jujube, isolate cyclic nucleotide high fructose syrup excellent tonic product.The health care that can be used for crowds such as old, weak, sick, woman is taken good care of.
In sum, extracting method of the present invention has been realized developing the purpose of multiple product by the activeconstituents of jujube and physicochemical property.
Embodiment
Further specify characteristics of the present invention below by specific embodiment
Embodiment
With Removing Kernel for Date (yield about 85%), oven dry, pulverize after being cooled to room temperature, cross 40 mesh sieves, get 50kg and mix, in the diacolation bucket of packing into, extract with diacolation under the 75% ethanol room temperature with equivalent 75% ethanol, collect vat liquor 200kg, the residue centrifugation goes out residual solvent, dries in vacuum drying oven again, gets the about 10kg of jujube dietary cellulose, pulverize the back and cross 60 mesh sieves, directly the tablet of compacting 1 grammes per square metre is the jujube diet cellulose tablet: extracting solution is merged diatomite filtration, concentrate and reclaim ethanol to 60 liters of cumulative volumes, be cooled to below 25 ℃, divide 2 extractions, combining extraction liquid with 60 liters of ethyl acetate, solvent is reclaimed in evaporation under 0.075Mpa vacuum tightness, gets paste jujube wax 0.4kg; Raffinate is concentrated into 65-70% (weight), gets the about 40kg of big date cyclic nucleotide syrup, and wherein cyclic monophosphate content is about 100 microgram/grams, is the finished product date cyclic nucleotide syrup after the packing sterilization.
Claims (2)
1. the separating and extracting method of a date cyclic nucleotide syrup, food fibre and jujube wax is characterized in that comprising following preparation process:
(1) be 0.06-0.098Mpa, 60-100 ℃ of following vacuum-drying with ripe jujube or wild jujube pulp in vacuum tightness, pulverize dried jujube pulp cooling back, with ethanol the pure soluble components lixiviate in the jujube powder is come out, alcoholic acid content 60-100% (volume/volume) in solvent during lixiviate, perhaps flatten sophisticated dried jujube broken, directly extract with the ethanol circulation, obtain alcohol extract and alcohol extracting residue, described extracting mode comprises percolation, single-stage or multistage pickling process, continuous countercurrent extraction, circumfluence method.
(2) make the jujube dietary fibrin powder after the alcohol extracting residue solvent evaporated that step (1) obtains, through sieve, compressing tablet or encapsulated, make jujube meals cellulose tablet or capsule, wherein main component is: solubility jujube polysaccharide, Mierocrystalline cellulose, crude protein;
(3) step (1) gained is pure that extract concentrates recovery ethanol earlier, isolates jujube wax with organic solvent extraction then, and described organic solvent comprises ethyl acetate, ether, butanols, amylalcohol, sherwood oil and composition thereof.
(4) raffinate of step (2) is made date cyclic nucleotide syrup with method of enrichment, and cyclic monophosphate content wherein can reach 100 microgram/grams, soluble solid content 65-72% (weight).
2. when in accordance with the method for claim 1, it is characterized in that step (1) lixiviate in the solvent alcoholic acid content be 75-95% (volume/volume).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB021307571A CN1175758C (en) | 2002-09-25 | 2002-09-25 | Separating and extracting method for date cyclic nucleotide syrup, dietary fibre and date wax |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB021307571A CN1175758C (en) | 2002-09-25 | 2002-09-25 | Separating and extracting method for date cyclic nucleotide syrup, dietary fibre and date wax |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1408257A true CN1408257A (en) | 2003-04-09 |
| CN1175758C CN1175758C (en) | 2004-11-17 |
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| CNB021307571A Expired - Fee Related CN1175758C (en) | 2002-09-25 | 2002-09-25 | Separating and extracting method for date cyclic nucleotide syrup, dietary fibre and date wax |
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Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009070921A1 (en) * | 2007-11-30 | 2009-06-11 | Chi, Yu-Fen | Antimelancholic medicine prepared with jujube camp materials |
| CN101288468B (en) * | 2008-05-23 | 2011-07-20 | 山西省农业科学院农产品综合利用研究所 | Method of sequential extraction of biological activity component from jujube |
| RU2456014C2 (en) * | 2007-11-30 | 2012-07-20 | Цзогуан ЧЖАН | ANTIMELANCHOLIC MEDICINE PREPARED WITH JUJUBA cAMP MATERIALS |
| CN102670764A (en) * | 2012-05-07 | 2012-09-19 | 南京中医药大学 | Active parts of wild jujube as well as preparation method and application thereof |
| CN101926452B (en) * | 2009-12-25 | 2012-12-05 | 河北农业大学 | Wild jujube leaf total flavonoids extract and preparation method thereof |
| CN102875625A (en) * | 2012-10-29 | 2013-01-16 | 北京林业大学 | Extraction method of cyclic adenosine monophosphate (cAMP) with antiallergic activity from Chinese date |
| CN103623080A (en) * | 2013-09-25 | 2014-03-12 | 中恩（天津）医药科技有限公司 | High-content jujube cyclic adenosine monophosphate extract and preparation method thereof |
| CN107259426A (en) * | 2016-04-07 | 2017-10-20 | 河北农业大学 | A kind of process for purification of jujube cyclic adenosine monophosphate syrup |
| CN109651471A (en) * | 2018-12-29 | 2019-04-19 | 河北科技大学 | The extracting method of cyclic adenosine monophosphate and cyclic guanosine monophosphate in jujube fruit |
-
2002
- 2002-09-25 CN CNB021307571A patent/CN1175758C/en not_active Expired - Fee Related
Cited By (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009070921A1 (en) * | 2007-11-30 | 2009-06-11 | Chi, Yu-Fen | Antimelancholic medicine prepared with jujube camp materials |
| RU2456014C2 (en) * | 2007-11-30 | 2012-07-20 | Цзогуан ЧЖАН | ANTIMELANCHOLIC MEDICINE PREPARED WITH JUJUBA cAMP MATERIALS |
| CN101288468B (en) * | 2008-05-23 | 2011-07-20 | 山西省农业科学院农产品综合利用研究所 | Method of sequential extraction of biological activity component from jujube |
| CN101926452B (en) * | 2009-12-25 | 2012-12-05 | 河北农业大学 | Wild jujube leaf total flavonoids extract and preparation method thereof |
| CN102670764A (en) * | 2012-05-07 | 2012-09-19 | 南京中医药大学 | Active parts of wild jujube as well as preparation method and application thereof |
| CN102875625A (en) * | 2012-10-29 | 2013-01-16 | 北京林业大学 | Extraction method of cyclic adenosine monophosphate (cAMP) with antiallergic activity from Chinese date |
| CN102875625B (en) * | 2012-10-29 | 2015-07-08 | 北京林业大学 | Extraction method of cyclic adenosine monophosphate (cAMP) with antiallergic activity from Chinese date |
| CN103623080A (en) * | 2013-09-25 | 2014-03-12 | 中恩（天津）医药科技有限公司 | High-content jujube cyclic adenosine monophosphate extract and preparation method thereof |
| CN103623080B (en) * | 2013-09-25 | 2015-10-21 | 中恩（天津）医药科技有限公司 | High-content jujube cyclic adenosine monophosphate extract and preparation method thereof |
| CN107259426A (en) * | 2016-04-07 | 2017-10-20 | 河北农业大学 | A kind of process for purification of jujube cyclic adenosine monophosphate syrup |
| CN107259426B (en) * | 2016-04-07 | 2021-02-09 | 河北农业大学 | Method for refining date cyclic adenosine monophosphate syrup |
| CN109651471A (en) * | 2018-12-29 | 2019-04-19 | 河北科技大学 | The extracting method of cyclic adenosine monophosphate and cyclic guanosine monophosphate in jujube fruit |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1175758C (en) | 2004-11-17 |
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